Cc1cccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)c1 CHEMBL196363 pKi 0.07943 nM
Cn1nccc1-c1ccn2c(C(=O)Nc3cc(C(=O)NCc4ccc(F)c(F)c4)ccc3F)cnc2c1 CHEMBL3904768 IC50 0.09 nM
CN1CCN(c2ccccc2CNC(=O)c2ccc(F)c(NC(=O)c3cnc4cc(-c5ccnn5C)ccn34)c2)CC1 CHEMBL3979322 IC50 0.18 nM
Cn1cc(-c2ccn3c(C(=O)Nc4cc(C(=O)NCCN5CCCC5(C)C)ccc4F)cnc3c2)cn1 CHEMBL3940697 IC50 0.19 nM
Cc1ncc(C(=O)NCCN2CCCC2(C)C)cc1NC(=O)c1cnn2cc(-c3cnn(C)c3)ccc12 CHEMBL3915941 IC50 0.2 nM
COc1cc(O)c2c(c1)/C=C/C[C@@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O CHEMBL1668411 IC50 0.24 nM
CN1CCN(c2ccccc2CNC(=O)c2ccc(F)c(NC(=O)c3cnc4cc(-c5cnn(C)c5)ccn34)c2)CC1 CHEMBL3913766 IC50 0.32 nM
COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1 CHEMBL491473 Kd 0.41 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.418 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL5416410 Kd 0.47 nM
COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1 CHEMBL1908396 Kd 0.49 nM
CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL1289926 Kd 0.51 nM
Cn1nccc1-c1ccn2c(C(=O)Nc3cc(C(=O)NCC4CCC(C)(C)O4)ccc3F)cnc2c1 CHEMBL3975580 IC50 0.53 nM
Cc1ccc(C(=O)Nc2ccc(NC(=O)CCl)c(C(F)(F)F)c2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL3642837 IC50 0.73 nM
CN1CCN(c2ccccc2CNC(=O)c2ccc(F)c(NC(=O)c3cnc4cc(-c5cccnc5)ccn34)c2)CC1 CHEMBL3950278 IC50 0.75 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 0.79 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 pKi 0.7943 nM
Cc1ncc(C(=O)NCc2ccccc2N2CCN(C)CC2)cc1NC(=O)c1cnn2cc(-c3ccnn3C)ccc12 CHEMBL3985689 IC50 0.96 nM
COc1ccc(NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]cc(C(=O)O)c2C)cc1 CHEMBL1173411 IC50 0.98 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ncccc3O)cc2)no1 CHEMBL1079545 Kd 1.0 nM
Cn1cc(Nc2ncc(Br)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)cn1 CHEMBL2071201 IC50 1.0 nM
COCCOc1cc(F)c2c(Nc3ccc(NC(=O)Cn4cc(C(C)C)nn4)cc3)ncnc2c1 CHEMBL4216473 GI50 1.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 1.1 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1171837 IC50 1.1 nM
COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cnn(C)c1 CHEMBL5176837 IC50 1.1 nM
O=C1Nc2ccccc2/C1=C/c1c[nH]nc1-c1ccccc1[N+](=O)[O-] CHEMBL2347053 IC50 1.2 nM
CN1CCN(c2ccccc2CNC(=O)c2ccc(F)c(NC(=O)c3cnn4cc(-c5ccnn5C)ccc34)c2)CC1 CHEMBL3947262 IC50 1.2 nM
CCN(CC)CCCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL1999414 pKi 1.259 nM
CNC(=O)c1ncc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(CCO)CC4)c(C(F)(F)F)c3)ccc2C)n1C CHEMBL1784637 IC50 1.3 nM
CCN1C(C)(C)CC(Oc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1(C)C CHEMBL2206278 Kd 1.3 nM
Cn1nccc1-c1ccn2c(C(=O)Nc3cc(C(=O)NCCN4CCCC4(C)C)ccc3F)cnc2c1 CHEMBL3955987 IC50 1.3 nM
C[C@@H]1CCC[C@H](C)N1CCNC(=O)c1ccc(F)c(NC(=O)c2cnc3cc(-c4ccnn4C)ccn23)c1 CHEMBL3895824 IC50 1.3 nM
Nc1nccc(COc2ccc3nc(N[C@H]4CCCC[C@@H]4O)sc3c2)c1Cl CHEMBL4741283 Kd 1.3 nM
Cc1ccc(NC(=O)c2ccc(NC(=O)/C=C/CN(C)C)c(C(F)(F)F)c2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL3642835 IC50 1.4 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(O)CO)c5)cnc(N)c34)cc2)cc1 CHEMBL1965170 pKi 1.585 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(F)c4F)cc3)c2cc1OC CHEMBL179698 IC50 1.6 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCOCC5)ccc34)cc2)no1 CHEMBL576982 Kd 1.6 nM
CCN(CCNC(=O)c1ccc(F)c(NC(=O)c2cnc3cc(-c4ccnn4C)ccn23)c1)C(C)(C)C CHEMBL3902237 IC50 1.6 nM
Cc1nc(NC(=O)CN2CCN(C)CC2)sc1-c1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL4794404 GI50 1.7 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 IC50 1.9 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 CHEMBL49120 pKi 1.995 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL941 pIC50 1.995 nM
COc1ccc(NC(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)cc1 CHEMBL179593 IC50 2.0 nM
COc1cccc(NC(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)c1 CHEMBL178156 IC50 2.0 nM
COc1cc2ncnc(Oc3ccc(CC(=O)Nc4cnn(C(C)C)c4)cc3)c2cc1OC CHEMBL1940274 INH 2.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2cccc(F)c2)c2nc(C)c[nH]2)C(=O)N3)CC1 CHEMBL2087167 IC50 2.0 nM
CN1CCN(Cc2ccc(NC(=O)CCSc3ccc4c(/C=C/c5ccccn5)n[nH]c4c3)cc2C(F)(F)F)CC1 CHEMBL4439424 GI50 2.0 nM
Cc1ccc(C(=O)Nc2ccc(CN3Cc4cn[nH]c4C3)c(Cl)c2)cc1C#Cc1cnc2cccnn12 CHEMBL4638981 IC50 2.0 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2[nH]ncc2c1 CHEMBL2316582 IC50 2.08 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCC4C=NNC4C3)c(Cl)c2)cc1C#Cc1cnc2cccnn12 CHEMBL4640297 IC50 2.1 nM
C=CC(=O)Nc1ccc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc1C(F)(F)F CHEMBL3642830 IC50 2.2 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC CHEMBL1289494 IC50 2.26 nM
CCN1CCC(Oc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1 CHEMBL2203434 Kd 2.3 nM
COc1cc(O)c2c(c1)CCC[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O CHEMBL2012519 IC50 2.38 nM
COc1cc2c(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCCN1CCCCC1 CHEMBL124660 Kd 2.4 nM
CCN1CCN(c2ccc(Nc3ncc(C)c(Nc4ccc5cn[nH]c5c4)n3)cc2OC)CC1 CHEMBL5184634 IC50 2.4 nM
CN1C(C)(C)CC(Oc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1(C)C CHEMBL2206277 Kd 2.5 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4ccc(OC(F)F)cc4)cc3)c12 CHEMBL1972220 pKi 2.512 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)(C)O)c5)cnc(N)c34)cc2)cc1 CHEMBL2004290 pKi 2.512 nM
CNCC#Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL1964441 pKi 2.512 nM
Cc1cccc(C(=O)Nc2cccc([C@H](C)Nc3cncc(Cl)n3)c2)c1 CHEMBL504075 Kd 3.0 nM
COc1ccc2c(Oc3ccc(CC(=O)Nc4cn(C)nc4C)c(OC)c3)ccnc2c1 CHEMBL2023489 IC50 3.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2ccccc2)c2nc4ccccc4[nH]2)C(=O)N3)CC1 CHEMBL2086753 IC50 3.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2ccc(Cl)cc2)c2ncc[nH]2)C(=O)N3)CC1 CHEMBL2086760 IC50 3.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2cc(F)cc(F)c2)c2nc(C)c[nH]2)C(=O)N3)CC1 CHEMBL2087168 IC50 3.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)O)c5)cnc(N)c34)cc2)c1 CHEMBL1989708 pKi 3.162 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3coc4c(C#CCN5CCOCC5)cnc(N)c34)cc2)c1 CHEMBL1983640 pKi 3.162 nM
CN(CCNC(=O)c1ccc(F)c(NC(=O)c2cnc3cc(-c4ccnn4C)ccn23)c1)C(C)(C)C CHEMBL3967097 IC50 3.2 nM
[2H]C([2H])([2H])Oc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC([2H])([2H])[2H] CHEMBL3426917 IC50 3.26 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(C)c4)cc3)c2cc1OC CHEMBL369760 IC50 3.3 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2cc1OC CHEMBL360526 IC50 3.4 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4c(F)cccc4F)cc3)c2cc1OC CHEMBL179307 IC50 3.5 nM
COc1ccc(NC(=O)Nc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)cc1 CHEMBL179603 IC50 3.6 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4)cc3)c2cc1OC CHEMBL368252 IC50 3.6 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4C)cc3)c2cc1OC CHEMBL179061 IC50 3.6 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 IC50 3.6 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4F)cc3)c2cc1OC CHEMBL179227 IC50 3.9 nM
COc1cc2nccc(Oc3ccc(NC(=O)NC(=O)c4ccccc4C)cc3)c2cc1OC CHEMBL203227 IC50 4.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1N1Cc2cnc(N)nc2N(C)C1=O CHEMBL459850 EC50 4.0 nM
O=C(Nc1cncnc1)c1c(Cl)ccc2c(Nc3cccc(C(F)(F)F)c3)noc12 CHEMBL491429 IC50 4.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL223360 Kd 4.2 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cn4c(n3)sc3ccccc34)cc2)no1 CHEMBL575925 Kd 4.3 nM
Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)ccc2C)n(C)n1 CHEMBL2180604 IC50 4.3 nM
COc1cc2c(Oc3ccc(NC(=O)c4cc5cccnc5n(-c5ccc(F)cc5)c4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4279457 IC50 4.35 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1)c1ccccc1 CHEMBL4165429 IC50 4.4 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(F)ccc4F)cc3)c2cc1OC CHEMBL179522 IC50 4.7 nM
Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O CHEMBL477772 Kd 4.9 nM
COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)c4ccccc4Cl)cc3)c2cc1OC CHEMBL202919 IC50 5.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Oc4ccccc4)cc3)c2cc1OC CHEMBL380703 IC50 5.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2ccc(C)cc2)c2nc4ccccc4[nH]2)C(=O)N3)CC1 CHEMBL2086754 IC50 5.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2nc(C)c[nH]2)c2ccccc2F)C(=O)N3)CC1 CHEMBL2087169 IC50 5.0 nM
Cc1ccc(NC(=O)c2ccc(CNC(=O)c3cccnc3)c(C(F)(F)F)c2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL4238799 GI50 5.0 nM
Nc1ccccc1-c1ccc(Nc2nc(N[C@H]3CC[C@H](N)CC3)nc3c2ncn3C2CCCC2)cc1 CHEMBL4558664 IC50 5.0 nM
Cc1nc(NC(=O)NC(=O)CC2CCCCC2)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5176270 IC50 5.1 nM
Cc1nc(NC(=O)NC(=O)C2CCCCC2)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5177368 IC50 5.1 nM
COc1cc(Nc2ncc(C)c(Nc3ccc4cn[nH]c4c3)n2)ccc1N1CCN(C)CC1 CHEMBL5173185 IC50 5.35 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 5.6 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(C#Cc4cncc(N5CCOCC5)c4)c3)cc2C(F)(F)F)CC1 CHEMBL4091628 IC50 5.6 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c2cc1OC CHEMBL180331 IC50 5.8 nM
COc1ccccc1NC(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cc1 CHEMBL426047 IC50 5.8 nM
Cc1ccc(C(=O)Nc2ccc(NC(=O)/C=C/CN(C)C)c(C(F)(F)F)c2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL3642836 IC50 5.9 nM
COc1cc2ncnc(Oc3ccc(NC(=O)NC(=O)c4ccccc4C)cc3)c2cc1OC CHEMBL203279 IC50 6.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)NCCC4CCCCC4)cc3)c2cc1OC CHEMBL425935 IC50 6.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2ccccc2)c2nc4cc(OC)ccc4[nH]2)C(=O)N3)CC1 CHEMBL2086751 IC50 6.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2cc(F)cc(F)c2)c2nc4ccccc4[nH]2)C(=O)N3)CC1 CHEMBL2086757 IC50 6.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2cccc(F)c2)c2ncc[nH]2)C(=O)N3)CC1 CHEMBL2086759 IC50 6.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(-n4cnnc4)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL4576574 IC50 6.0 nM
CNC(=O)c1ccccc1Sc1ccc2c(C=Cc3ccccn3)n[nH]c2c1 CHEMBL1988437 pKi 6.31 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c2cc1OC CHEMBL426602 IC50 6.4 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(-n2cccc2CN(C)C)cc1)c1ccccc1 CHEMBL4069394 IC50 6.6 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4[N+](=O)[O-])cc3)c2cc1OC CHEMBL360781 IC50 6.8 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)c(F)c4)cc3)c2cc1OC CHEMBL179719 IC50 6.8 nM
COc1cc2ncnc(Oc3ccc(NC(=O)NC4CCCCC4)cc3)c2cc1OC CHEMBL205089 IC50 7.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(CCCN(C)C)C(C)=O)cc1)c1ccccc1 CHEMBL525909 IC50 7.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2ccc(OC)cc2)c2nc4ccccc4[nH]2)C(=O)N3)CC1 CHEMBL2086755 IC50 7.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2cccc(F)c2)c2nc4ccccc4[nH]2)C(=O)N3)CC1 CHEMBL2086756 IC50 7.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(-n4cccn4)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL4444476 IC50 7.0 nM
O=C(CC(=O)Nc1ccc2c(c1)NC(=O)/C2=C\c1ccc[nH]1)Nc1ccc(F)cc1 CHEMBL3322563 IC50 7.2 nM
Cc1cc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(C)c34)cc2)ccc1N1CCOCC1 CHEMBL4072731 IC50 7.2 nM
COc1cc(O)c2c(c1)CCC[C@H](O)CC(=O)/C=C\C[C@H](C)OC2=O CHEMBL1651521 IC50 7.23 nM
Cc1nc(Nc2nc3ccc(-c4cccc(C(=O)Nc5cccc(C(F)(F)F)c5)c4)nc3s2)cc(N2CCNCC2)n1 CHEMBL2148120 Kd 7.7 nM
C=CC(=O)N1CCc2cc(C(=O)Nc3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)ccc2C1 CHEMBL3642840 IC50 7.9 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 7.943 nM
CCN(CC)CCCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)csc12 CHEMBL1996649 pKi 7.943 nM
COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)c4ccccc4)cc3)c2cc1OC CHEMBL378489 IC50 8.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)Cn2ccnc2)cc1)c1ccccc1 CHEMBL524453 IC50 8.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(CCN(C)C)C(C)=O)cc1)c1ccccc1 CHEMBL498265 IC50 8.0 nM
CC(=O)Nc1cn2cc(-c3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)ccc2n1 CHEMBL4216073 IC50 8.0 nM
C=CC(=O)Nc1cccc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)c1 CHEMBL4247977 GI50 8.0 nM
Cc1cc(NC(=O)c2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc(-n2cnc(C)c2)c1 CHEMBL2311806 IC50 8.2 nM
COc1cc2ncnc(Oc3ccc(NC(=O)NCCC4CCCCC4)cc3)c2cc1OC CHEMBL204225 IC50 9.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(CC(=O)N(C)C)C(C)=O)cc1)c1ccccc1 CHEMBL498088 IC50 9.0 nM
Cc1ccn(-c2cccc(C(F)(F)F)c2)c(=O)c1-c1ccc2nc(N)ncc2c1 CHEMBL504805 IC50 9.0 nM
N[C@H]1CC[C@@H](Nc2cc[nH]c(=O)c2-c2nc3ccccc3[nH]2)CC1 CHEMBL3780091 IC50 9.0 nM
COc1ccc(-c2cnn3c(N)c(-c4nccs4)c(OC4CCN(C)CC4)nc23)cc1OC CHEMBL4636995 IC50 9.0 nM
FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1 CHEMBL3813873 IC50 9.6 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc4ccccc4cn3)cc2)no1 CHEMBL1081509 Kd 9.9 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(Cl)cc4)cc3)c2cc1OC CHEMBL179165 IC50 10.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(F)cc(F)c4)cc3)c2cc1OC CHEMBL179816 IC50 10.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 IC50 10.0 nM
CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc21 CHEMBL572881 Kd 10.0 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 10.0 nM
COCCN1CCC(Nc2ccc3c(c2)C(=C(c2ccccc2)c2nc4ccccc4[nH]2)C(=O)N3)CC1 CHEMBL2086752 IC50 10.0 nM
Cn1cc(-c2cc3c(N4CCN(c5ncc([C@@](C)(N)c6ccc(F)cc6)cn5)CC4)ncnn3c2)cn1 CHEMBL4204794 GI50 10.0 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(/C=C/c3ccccc3)n2)n[nH]1 CHEMBL482968 IC50 10.0 nM
CC1(COc2ccc3c(c2)ncn3-c2ccc3cccc(N4CCC(N)CC4)c3n2)COC1 CHEMBL2105728 IC50 10.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(C)c34)cc2)c1 CHEMBL4103605 GI50 10.4 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cnc5ccccc5c4)cc3)c12 CHEMBL4091975 GI50 10.4 nM
CCCCCCNC(=O)Nc1ccc(-c2ccnc3[nH]nc(C)c23)cc1 CHEMBL4074755 GI50 10.4 nM
Cc1cccc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(CO)c34)cc2)c1 CHEMBL4083050 GI50 10.4 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)NCCCc4ccccc4)cc3)c12 CHEMBL4101428 GI50 10.4 nM
Cc1ccc(NC(=O)c2ccc(CN3C(=O)C=CC3=O)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL3642843 IC50 10.69 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(C(=O)N(C)CCN(C)C)cc1)c1ccccc1 CHEMBL525550 IC50 11.0 nM
Cc1cc2c(F)c(Oc3ncnn4cc(OC[C@@H](C)O)c(C)c34)ccc2[nH]1 CHEMBL377300 Kd 11.0 nM
C=CC(=O)N(CCN(C)C)Cc1ccc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc1 CHEMBL4242508 GI50 11.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(-n4cncn4)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL4444046 IC50 11.0 nM
CSCCCNC(=O)c1ccc2c(c1)/C(=C/c1[nH]c(C)cc1C)C(=O)N2 CHEMBL3621299 IC50 11.8 nM
COc1cc2nccc(Oc3ccc(NC(=O)NC4CCCCC4)cc3)c2cc1OC CHEMBL205953 IC50 12.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(CCN(C)C)S(C)(=O)=O)cc1)c1ccccc1 CHEMBL498266 IC50 12.0 nM
Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1 CHEMBL2409778 IC50 12.0 nM
Cc1ccc(C(=O)N2CCC(Oc3cc(NC(=O)c4ccc(CN5CCN(C)CC5)c(C(F)(F)F)c4)ccc3C)CC2)cn1 CHEMBL3939150 GI50 12.0 nM
CCC(=O)Nc1ccc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc1 CHEMBL4242986 GI50 12.0 nM
Nc1nccc(COc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2)c1Cl CHEMBL4759047 Kd 12.0 nM
Nc1nccc(COc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2Cl)c1Cl CHEMBL4798601 Kd 12.0 nM
CCN(CC)CCNC(=O)C=Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL2004716 pKi 12.59 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3Cl)c2cc1OC CHEMBL360349 IC50 13.0 nM
CCCCNC(=O)c1ccc2c(c1)C(=C(c1ccccc1)c1nc3ccccc3[nH]1)C(=O)N2 CHEMBL2086744 IC50 13.0 nM
O=C(Nc1cccc(Oc2ccc3nccn3n2)c1)c1cccc(C(F)(F)F)c1 CHEMBL2206666 IC50 13.0 nM
CN1CCC(Nc2ccc3c(c2)/C(=C/c2cc4c([nH]2)CCN(C(=O)N2CCOCC2)C4)C(=O)N3)CC1 CHEMBL2403373 IC50 13.0 nM
CN1CCN(c2ccccc2CNC(=O)c2ccc(F)c(NC(=O)c3cnc4ccccn34)c2)CC1 CHEMBL3971140 IC50 13.0 nM
C=CC(=O)Nc1cc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc(C(F)(F)F)c1 CHEMBL4243753 GI50 13.0 nM
Cc1ccc(NC(=O)c2ccc(NC(=O)c3cccnc3)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL4239972 GI50 13.0 nM
C=CS(=O)(=O)NCc1ccc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc1 CHEMBL4245969 GI50 13.0 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)NC4CCCC4)cc3)c12 CHEMBL4085974 GI50 13.3 nM
COc1ccc(NC(=O)Nc2ccc(Sc3ccnc4cc(OC)c(OC)cc34)cc2)cc1 CHEMBL362486 IC50 14.0 nM
Cc1cn(-c2cccc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)c2)cn1 CHEMBL2311808 Kd 14.0 nM
COCCOc1cc2ncnc(N3CCN(c4ncc(Cc5ccccc5)cn4)CC3)c2cc1OCCOC CHEMBL4205999 Kd 14.0 nM
Cc1ccc(NC(=O)c2ccc(CNC(=O)c3cccnc3)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL4245489 GI50 14.0 nM
CCC(=O)NCc1ccc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc1 CHEMBL4238660 GI50 14.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(Oc4nccs4)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL4540307 IC50 14.0 nM
Cn1cc(-c2cc(Oc3ccc(NC(=O)NC(=O)Cc4ccc(F)cc4)cc3F)ccn2)cn1 CHEMBL5190097 IC50 14.0 nM
COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)C4CCCCC4)cc3)c2cc1OC CHEMBL204120 IC50 15.0 nM
CCC(=O)NCc1cccc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)c1 CHEMBL4247213 GI50 15.0 nM
CCc1nnc(-c2c(OC)cc(-c3cnc4cc(-c5cnn(C)c5)ccn34)cc2OC)o1 CHEMBL5407103 IC50 15.0 nM
Cc1cnc(Nc2ccc(N3CCOCC3)cc2)nc1Nc1ccc2cn[nH]c2c1 CHEMBL5176371 IC50 15.1 nM
Cc1cnc(Nc2ccc(C(=O)NCCN3CCOCC3)cc2)nc1Nc1ccc2cn[nH]c2c1 CHEMBL5206707 IC50 15.6 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccc(F)cc5)c(=O)c5ccccc45)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3309402 IC50 15.73 nM
Nc1c(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)cnc2c(-c3ccc4c(c3)OCO4)cnn12 CHEMBL1977134 pKi 15.85 nM
Cc1ccc(NC(=O)c2ccc(NC(=O)CCl)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL3642833 IC50 16.4 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc([N+](=O)[O-])cc4)cc3)c2cc1OC CHEMBL178568 IC50 17.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3F)c2cc1OC CHEMBL179815 IC50 17.0 nM
CCN1CCC(Oc2ccc3c(c2)C(=C(c2ccccc2)c2nc4cc(OC)ccc4[nH]2)C(=O)N3)CC1 CHEMBL2086749 IC50 17.0 nM
Cc1ccc(NC(=O)c2ccc(CN(CCN(C)C)C(=O)C(C)(C)C)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL4251137 GI50 17.0 nM
COC(=O)Nc1ccc(-c2c(OC3CCN(C)CC3)nc3c(-c4ccc(OC)c(OC)c4)cnn3c2N)cc1 CHEMBL4634073 IC50 17.0 nM
NC(=O)c1ccc(Nc2nc(N[C@H]3CC[C@H](N)CC3)nc3c2ncn3C2CCCC2)cc1 CHEMBL5188322 IC50 17.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc([N+](=O)[O-])c4)cc3)c2cc1OC CHEMBL179360 IC50 18.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)OCCC4CCCCC4)cc3)c2cc1OC CHEMBL425043 IC50 18.0 nM
COC(=O)c1ccc2c(C(Nc3ccc(N(C)C(=O)CN4CCN(C)CC4)cc3)c3ccccc3)c(O)[nH]c2c1 CHEMBL5201102 IC50 18.0 nM
CCN1CCN(c2ccc(Nc3ncc(C)c(Nc4ccc5cn[nH]c5c4)n3)cc2)CC1 CHEMBL5208704 IC50 18.0 nM
C=CS(=O)(=O)Nc1ccc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc1 CHEMBL3642839 IC50 18.8 nM
C=CC(=O)N(CCC(C)C)Cc1ccc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc1 CHEMBL4245029 GI50 19.0 nM
COc1cc2c(Oc3ccc(NC(=O)c4nc5ccccc5n(-c5ccc(F)cc5)c4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4082724 IC50 19.13 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5cccc(F)c5)cccc4c3)n2)c1 CHEMBL3740487 IC50 19.6 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCCCCCCCCN)cnc(N)c34)cc2)c1 CHEMBL1978166 pKi 19.95 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN(C)C(=O)N(C)C)cc1)c1ccccc1 CHEMBL525203 IC50 20.0 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2ccccc2)c2ncc[nH]2)C(=O)N3)CC1 CHEMBL2086758 IC50 20.0 nM
Nc1nc(Nc2ccc3c(c2)CC[C@@H](N2CCCC2)CC3)nn1-c1cc2c(nn1)-c1ccccc1CCC2 CHEMBL3809489 IC50 20.0 nM
COc1ccc(NC(=O)Nc2ccc(Nc3ccnc4cc(OC)c(OC)cc34)cc2)cc1 CHEMBL179753 IC50 21.0 nM
Cn1cc(-c2cc(Oc3ccc(NC(=O)NC(=O)Cc4ccc(F)cc4)nc3)ccn2)cn1 CHEMBL5176985 IC50 21.0 nM
CS(=O)(=O)c1ccc(-c2ccc3c(NC4CCC4)c(C(N)=O)nnc3c2)cc1 CHEMBL2333129 IC50 22.0 nM
CCc1cccc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(C)c34)cc2)c1 CHEMBL4074518 IC50 22.0 nM
CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(N5CCN(CCO)CC5)cc4)c3)ccc12 CHEMBL4278642 IC50 22.6 nM
Cc1cc(NC(=O)NC(=O)Cc2ccc(F)cc2)ncc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5186979 IC50 23.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c2cc1OC CHEMBL362188 IC50 24.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(Cl)c4Cl)cc3)c2cc1OC CHEMBL178981 IC50 24.0 nM
Cc1cn(-c2cc(F)cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)c2)cn1 CHEMBL2311807 Kd 24.0 nM
Cc1ccc(NC(=O)c2ccc(CNCCN(C)C)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL4237427 GI50 24.0 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nc(-c2cccnc2)cs1 CHEMBL1908391 Kd 25.0 nM
CCCC(=O)N(CCN(C)C)Cc1ccc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc1 CHEMBL4244760 GI50 25.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(-c4ccoc4)nc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL4547030 IC50 25.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(C(F)(F)F)c4)cc3)c2cc1OC CHEMBL4577779 IC50 25.0 nM
Cc1cnc(Nc2ccc(C(=O)N3CCN(C)CC3)cc2)nc1Nc1ccc2cn[nH]c2c1 CHEMBL5188763 IC50 25.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CCO)c5)cnc(N)c34)cc2F)c1 CHEMBL1986851 pKi 25.12 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(-c4ccccc4O)nc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL4514237 IC50 26.0 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 27.0 nM
COc1cc(O)c2c(c1)/C=C/CCCC(=O)/C=C/C[C@H](C)OC2=O CHEMBL1668418 IC50 27.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 27.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(CN4CCOCC4)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL4204373 IC50 27.0 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5C(F)(F)F)c5ccccc5c4=O)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL2385195 IC50 27.3 nM
COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3)c2cc1OC CHEMBL205372 IC50 28.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN(C)C)cc1)c1ccccc1 CHEMBL498105 IC50 28.0 nM
CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1 CHEMBL460702 IC50 28.0 nM
Nc1nccc(COc2ccc3nc(N[C@H]4CCCC[C@H]4O)sc3c2)c1Cl CHEMBL4798876 Kd 28.0 nM
C=CC(=O)NCc1ccc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc1 CHEMBL3642838 IC50 29.8 nM
CC(=O)N1CCc2[nH]c(/C=C3\C(=O)Nc4ccc([N+](=O)[O-])cc43)cc2C1 CHEMBL2403378 IC50 31.0 nM
CCc1cccc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(CO)c34)cc2)c1 CHEMBL4059958 IC50 32.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(-c4cccs4)nc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL4578470 IC50 32.0 nM
Nc1nccc(COc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2F)c1Cl CHEMBL4795462 Kd 32.0 nM
CCN(CC)CCN(Cc1ccc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc1)C(=O)c1cccnc1 CHEMBL4243958 GI50 33.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(N4CCN(Cc5ccccc5)CC4)cc3)c3ncn(C4CCC(O)C4)c3n2)CC1 CHEMBL4550659 IC50 33.0 nM
Cc1ccc(NC(=O)c2ccc(CN(CCN(C)C)C(=O)c3cccnc3)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL4247298 GI50 34.0 nM
Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)c(F)c3)c21 CHEMBL1254007 IC50 35.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3cccc(CN4CCOCC4)c3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL4552829 IC50 35.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(N4CCN(Cc5ccccc5)CC4)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL4217517 IC50 35.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(C)cc4)cc3)c2cc1OC CHEMBL362634 IC50 36.0 nM
CCC(=O)N(CCN(C)C)Cc1ccc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc1 CHEMBL4250559 GI50 36.0 nM
COc1ccccc1-c1ccc(Nc2nc(N[C@H]3CC[C@H](N)CC3)nc3c2ncn3C2CCCC2)cn1 CHEMBL4530087 IC50 36.0 nM
Cc1nc(NC(=O)NC(=O)C2CCCC2)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5174778 IC50 36.0 nM
NCCCCNC(=O)c1ccc(Nc2nc(N[C@H]3CC[C@H](N)CC3)nc3c2ncn3C2CCCC2)cc1 CHEMBL5176691 IC50 36.0 nM
Cc1cnc(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)cc2)nc1Nc1ccc2cn[nH]c2c1 CHEMBL5182087 IC50 36.5 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(Cl)cc4Cl)cc3)c2cc1OC CHEMBL179422 IC50 37.0 nM
COc1cc2ncnc(Oc3ccc(N/C(S)=N/CC4CCCCC4)cc3)c2cc1OC CHEMBL382399 IC50 37.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3cccc(CN4CCOCC4)c3)c3ncn(C4CCC(O)C4)c3n2)CC1 CHEMBL4442514 IC50 37.0 nM
CCN(CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1)CCOP(=O)(O)O CHEMBL415049 Kd 38.0 nM
CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1 CHEMBL215152 Kd 38.0 nM
CC1(C)CC(NC(=O)c2cccc(-c3cc4nccc(Nc5cccc(O)c5)n4n3)c2)CC(C)(C)N1[O] CHEMBL1163016 IC50 38.0 nM
Cc1ccc(NC(=O)c2ccc(CN(CCN3CCCC3)C(=O)c3cccnc3)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL4240820 GI50 39.0 nM
Cc1ccc(NC(=O)c2ccc(CN(CCN(C)C)C(=O)C(C)C)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL4240563 GI50 39.0 nM
CCC(=O)Nc1cc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc(C(F)(F)F)c1 CHEMBL4251023 GI50 39.0 nM
COc1ccc(-c2ccc(Nc3nc(N[C@H]4CC[C@H](N)CC4)nc4c3ncn4C3CCCC3)cn2)cc1 CHEMBL4536228 IC50 39.0 nM
COc1cc(-c2csc3c(C=CC(=O)NCCN(C)C)cnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C CHEMBL1989267 pKi 39.81 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(C=Cc3ccccc3)n2)n[nH]1 CHEMBL1983923 pKi 39.81 nM
COc1cc2nccc(Oc3ccc(N/C(S)=N/C4CCCCC4)cc3)c2cc1OC CHEMBL205674 IC50 40.0 nM
S=C(NCc1ccc2c(c1)OCO2)N1CCN(c2ncnc3c2oc2ccccc23)CC1 CHEMBL2105685 IC50 40.0 nM
CCn1c(=O)c(-c2cc(NC(=O)Nc3ccccc3)c(F)cc2Br)cc2cnc(NC)cc21 CHEMBL4216467 GI50 40.0 nM
NCCCNCCCCNC(=O)c1ccc(Nc2nc(N[C@H]3CC[C@H](N)CC3)nc3c2ncn3C2CCCC2)cc1 CHEMBL5189978 IC50 41.0 nM
Cc1cnc(Nc2ccc(N3CCS(=O)(=O)CC3)cc2)nc1Nc1ccc2cn[nH]c2c1 CHEMBL5187885 IC50 42.3 nM
COc1ccc(Nc2nccc(-c3cn(C)c4ccccc34)n2)cc1OCCOCCn1ccnc1[N+](=O)[O-] CHEMBL5426036 IC50 42.53 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(Cl)ccc4Cl)cc3)c2cc1OC CHEMBL369747 IC50 43.0 nM
CN(c1ccc(F)c(NC(=O)c2cccc(OC(C)(C)C#N)c2Cl)c1)c1ccc2nc(NC(=O)C3CC3)sc2n1 CHEMBL2204532 IC50 43.0 nM
O=c1c2cc(-c3ccnc4ccccc34)ccc2ncn1-c1ccc(N2CCOCC2)cc1 CHEMBL4244382 Kd 43.0 nM
C=CC(=O)Nc1ccc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc1 CHEMBL3642842 GI50 44.0 nM
COc1cc2c(cc1OC)-c1n[nH]c(Nc3cccc(F)c3)c1C2 CHEMBL120077 IC50 45.0 nM
Cn1cc(-c2nc(N[C@@H]3CCCC[C@@H]3N)c(F)c3c2C(=O)NC3)cn1 CHEMBL3979920 IC50 45.0 nM
CCC(=O)Nc1cc(Nc2ncc(C(=O)Nc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)c(NC)n2)ccc1C CHEMBL4093840 GI50 45.0 nM
COc1cc2ncnc(Oc3ccc(N/C(S)=N/Cc4ccccc4)cc3)c2cc1OC CHEMBL204409 IC50 46.0 nM
O=C1Nc2ccc(C(F)(F)F)cc2/C1=C/c1cc2c([nH]1)CCN(C(=O)N1CCOCC1)C2 CHEMBL2403372 IC50 46.0 nM
Nc1nccc(COc2ccc3nc(NC4CCCCC4)sc3c2)c1Cl CHEMBL4788945 Kd 46.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(Oc4ncccn4)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL4457463 IC50 47.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(CN4CCOCC4)cc3)c3ncn(C4CCC(O)C4)c3n2)CC1 CHEMBL4469917 IC50 47.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(C)c(Nc2ccc3cn[nH]c3c2)n1 CHEMBL5190076 IC50 49.6 nM
CCN1CCN(c2ccc(Nc3ncc(C)c(Nc4ccc5cn[nH]c5c4)n3)c(OC)c2)CC1 CHEMBL5190005 IC50 49.9 nM
COc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5ccccc5)cc4)CC3)c2cc1OC CHEMBL102346 IC50 50.0 nM
COC(=O)c1cc2cc(NCc3cc(NC(=O)c4cc(-n5cnc(C)c5)cc(C(F)(F)F)c4)ccc3C)cnc2[nH]1 CHEMBL3808884 IC50 50.0 nM
Cn1cc(-c2ccc(CNc3cc(-c4cnc5cc(OCCCN6CCCC6)ccn45)ncn3)cc2)cn1 CHEMBL5314917 IC50 50.0 nM
Cc1cc(=O)n2ccc(CN(C)C)c(O)c2n1 CHEMBL1988581 pKi 50.12 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1970317 pKi 50.12 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1 CHEMBL1946170 GI50 51.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(N)=O CHEMBL1289601 IC50 51.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)NC5CC5)CC4)c(Cl)c3)c2cc1C(N)=O CHEMBL5201128 IC50 51.0 nM
COc1cc2nccc(Oc3ccc(N/C(S)=N/c4ccc(F)cc4)cc3)c2cc1OC CHEMBL178276 IC50 52.0 nM
Cc1cc(C)cc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)c1 CHEMBL3114023 IC50 52.0 nM
CN(C)c1ccc2c(Oc3ccc(NC(=O)NCc4ccc(C(F)(F)F)nc4)cc3)ncnc2c1 CHEMBL4847875 IC50 52.7 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN2CCCCC2)cc1)c1ccccc1 CHEMBL497049 IC50 54.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 Kd 54.0 nM
C[C@@H](Nc1c(C(N)=O)nnc2cc(-c3ccc(S(C)(=O)=O)cc3)ccc12)C1CC1 CHEMBL2333128 IC50 54.0 nM
C/C=C/C(=O)N(CCN(C)C)Cc1ccc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc1 CHEMBL4243399 GI50 54.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(Cl)c(Cl)c4)cc3)c2cc1OC CHEMBL359617 IC50 55.0 nM
COCCNC(=O)c1ccc2c(c1)C(=C(c1ccccc1)c1nc3ccccc3[nH]1)C(=O)N2 CHEMBL2086397 IC50 55.0 nM
Cc1ccc(NC(=O)c2ccc(CN(CCN(C)C)C(=O)c3cccs3)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL4243521 GI50 56.0 nM
CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(CCCN(C)C)C(C)=O)cc1)c1ccccc1 CHEMBL1271736 IC50 59.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL3039504 IC50 59.0 nM
CC(C)CCn1cnc2c(Nc3ccc(Cl)cc3)nc(N[C@H]3CC[C@H](N)CC3)nc21 CHEMBL4218356 IC50 59.0 nM
C=CC(=O)NCc1ccc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc1C(F)(F)F CHEMBL4239216 GI50 59.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 60.0 nM
CC(=O)N1CCc2[nH]c(/C=C3\C(=O)Nc4ccc(C(F)(F)F)cc43)cc2C1 CHEMBL2403376 IC50 60.0 nM
COc1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCN(C(=O)N1CCN(C)CC1)C3)C(=O)N2 CHEMBL2403369 IC50 60.0 nM
CCCCn1cnc2c(Nc3ccc(Cl)cc3)nc(N[C@H]3CC[C@H](N)CC3)nc21 CHEMBL4209971 IC50 60.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1336 Kd 62.0 nM
C=CCNc1c(O)cc2c(O)c1C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(\C)[C@H](OC(N)=O)[C@@H](OC)/C=C\C=C(/C)C(=O)N2 CHEMBL377559 IC50 62.0 nM
Cc1cc(-c2cnc(N3CCCC3)[nH]c2=O)ncc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5174705 IC50 64.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc(C)c(Nc2ccc3cn[nH]c3c2)n1 CHEMBL5183593 IC50 64.7 nM
Cc1ccc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(C)c34)cc2)cc1 CHEMBL4088552 IC50 65.0 nM
COc1ccccc1-c1ccc(Nc2nc(N[C@H]3CC[C@H](N)CC3)nc3c2ncn3C2CCCC2)cc1 CHEMBL4475203 IC50 65.0 nM
CC(C)CCn1cnc2c(Nc3cccc(O)c3)nc(N[C@H]3CC[C@H](N)CC3)nc21 CHEMBL4205604 IC50 66.0 nM
CC(C)CCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CC[C@H](N)CC3)nc21 CHEMBL4210919 IC50 66.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC CHEMBL178455 IC50 67.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(C)c3)c2cc1OC CHEMBL1242557 IC50 67.0 nM
O=C(Cn1cc(Nc2nncc3cc(OCCCN4CCC[C@@H]4CO)ccc23)cn1)Nc1cccc(F)c1F CHEMBL253968 IC50 69.0 nM
Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1 CHEMBL255863 IC50 71.0 nM
CN(c1ccc2cn(C)nc2c1)c1ccnc(Nc2ccc(OC(F)(F)F)cc2)n1 CHEMBL3114029 IC50 72.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(-c4ccccc4O)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL4575858 IC50 73.0 nM
Cc1cnc(Nc2ccc(N3CCC(F)(F)CC3)cc2)nc1Nc1ccc2cn[nH]c2c1 CHEMBL5206811 IC50 73.6 nM
CC(C)COC(=O)Nc1ccc(-c2cnc3c(-c4ccc(N5CCN(C)CC5)cc4)cnn3c2N)cc1 CHEMBL1085511 IC50 74.0 nM
CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(CCN(C)C)S(C)(=O)=O)cc1)c1ccccc1 CHEMBL1272128 IC50 74.0 nM
CCC(=O)N1CC[C@H](N2C(=O)N(c3cc(OC)ccc3Cl)Cc3cnc(Nc4ccc(N5CCN(C6COC6)CC5)c(C)c4)nc32)C1 CHEMBL4066141 IC50 74.0 nM
NCCCCNc1nc(Nc2ccc(CN3CCOCC3)cc2)c2ncn(C3CCC(O)C3)c2n1 CHEMBL4562932 IC50 74.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(Cl)cc(Cl)c4)cc3)c2cc1OC CHEMBL440202 IC50 75.0 nM
Cc1cc(C)cc(Nc2nccc(N(C)c3ccc4cn(C)nc4c3)n2)c1 CHEMBL3114030 IC50 75.0 nM
COc1cccc(OC)c1CNc1nc(NC2CCCCC2)nc2ccc(Cl)cc12 CHEMBL1996646 pKi 79.43 nM
Nc1n[nH]c2c(OCCCn3cccc3)ccc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12 CHEMBL1965387 pKi 79.43 nM
Nc1c(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)ccc2nccnc12 CHEMBL2004438 pKi 79.43 nM
Cc1c(NC(=O)CCN2CCCC2)c[nH]c1/C=C1\C(=O)Nc2ccc(F)cc21 CHEMBL4869059 IC50 79.6 nM
Cc1cccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)c1 CHEMBL3114022 IC50 80.0 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)NCCc4ccccc4)cc3)c12 CHEMBL4100492 IC50 82.0 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cccc(N(C)C)c4)cc3)c12 CHEMBL4064941 IC50 83.0 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)NC4Cc5ccccc5C4)cc3)c12 CHEMBL4063368 IC50 83.0 nM
Cc1nc(NC(=O)NC(=O)CC2CCOCC2)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5179072 IC50 83.0 nM
CC(=O)Nc1cc(Oc2ccc(NC(=O)Cc3ccccc3C(F)(F)F)cc2)ncn1 CHEMBL5289631 IC50 83.8 nM
Cc1c2ccc(N(C)c3ccnc(Nc4cccc(Cl)c4)n3)cc2nn1C CHEMBL3114020 IC50 85.0 nM
COc1cccc(Nc2nccc(N(C)c3ccc4cn(C)nc4c3)n2)c1 CHEMBL3114028 IC50 86.0 nM
COc1cc(O)c2c(c1)/C=C/CCCC(=O)C[C@H](Br)C[C@H](C)OC2=O CHEMBL1668414 IC50 87.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(C)c34)cc2)c1 CHEMBL4074713 IC50 87.0 nM
COc1cc(O)c2c(c1)CCCCCC(=O)/C=C/C[C@H](C)OC2=O CHEMBL1668419 IC50 89.0 nM
COc1cc2ncnc(N3CCN(C(=O)Nc4ccc(C(C)C)cc4)CC3)c2cc1OC CHEMBL104067 IC50 90.0 nM
CC(=O)Nc1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCN(C(=O)N1CCOCC1)C3)C(=O)N2 CHEMBL2403374 IC50 91.0 nM
Cc1nc(NC(=O)NC(=O)C2CCC2)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5181597 IC50 92.0 nM
COc1ccc(-c2cnn3c(N)c(-c4ccccc4)c(OC4CCN(C)CC4)nc23)cc1OC CHEMBL4640601 IC50 93.0 nM
CSc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1 CHEMBL3114024 IC50 94.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(CN4CCOCC4)cc3)c3ncn(CCCO)c3n2)CC1 CHEMBL4564698 IC50 94.0 nM
Nc1nccc(COc2ccc3nc(N[C@@H]4CCCC[C@@H]4O)sc3c2)c1Cl CHEMBL4756510 Kd 94.0 nM
COc1cc(O)c2c(c1)CCCCCC(=O)/C=C\C[C@H](C)OC2=O CHEMBL1651523 IC50 95.0 nM
CN(c1ccc2cn(C)nc2c1)c1ccnc(Nc2cccc(Cl)c2)n1 CHEMBL3114027 IC50 95.0 nM
Cc1nc(NC(=O)NC(=O)C2CCOCC2)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5186614 IC50 95.0 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5F)c(=O)n4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL3946811 IC50 95.23 nM
Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1 CHEMBL101253 Kd 96.0 nM
COc1cccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)c1 CHEMBL3114021 IC50 96.0 nM
CC(C)CCn1cnc2c(Nc3ccccc3)nc(N[C@H]3CC[C@H](N)CC3)nc21 CHEMBL4210474 IC50 96.0 nM
Cc1c2ccc(N(C)c3ccnc(Nc4cccc(Br)c4)n3)cc2nn1C CHEMBL3114019 IC50 97.0 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cccc5ccccc45)cc3)c12 CHEMBL4099718 IC50 97.0 nM
CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN(C)C)cc1)c1ccccc1 CHEMBL1272289 IC50 99.0 nM
C=CC(=O)Nc1cc(Nc2ncc(C(=O)Nc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)c(NC)n2)ccc1C CHEMBL4064566 GI50 99.0 nM
CC(=O)Oc1ccc2[nH]c(C(=O)c3cc4ccccc4[nH]3)cc2c1 CHEMBL7572 IC50 100.0 nM
CN(C)CC(=O)Oc1ccc2[nH]c(C(=O)c3cc4ccccc4[nH]3)cc2c1 CHEMBL7432 IC50 100.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3ccc(OCCCn4cccc4)c4[nH]nc(N)c34)cc2)c1 CHEMBL2007266 pKi 100.0 nM
CN1c2ccc(N)cc2C(c2ccccc2)c2cc(N)ccc21 CHEMBL1991734 pKi 100.0 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 pKi 100.0 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 100.0 nM
Cc1ccc(C(=O)N(CCN(C)C)Cc2ccc(C(=O)Nc3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc2)cc1 CHEMBL4247752 GI50 100.0 nM
Cc1cnc(Nc2ccc(N3CCNCC3)cc2)nc1Nc1ccc2cn[nH]c2c1 CHEMBL5177453 IC50 102.4 nM
Cc1c2ccc(N(C)c3ccnc(Nc4ccc(OC(F)(F)F)cc4)n3)cc2nn1C CHEMBL3114025 IC50 104.0 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)c12 CHEMBL4065800 IC50 106.0 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5cccnc5)cccc4c3)n2)c1 CHEMBL3739732 IC50 106.8 nM
CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL1271853 IC50 107.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn(-c4ccc(OCCN5CCOCC5)cc4Cl)nn3)cc2)no1 CHEMBL4645320 Kd 110.0 nM
Cc1ccc(NC(=O)c2ccc(CN(CCN(C)C)C(=O)C3CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL4239175 GI50 112.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)c4cc(C)nc(C)c4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4877347 IC50 112.0 nM
NCCCCNc1nc(Nc2ccc(Oc3nccs3)cc2)c2ncn(C3CCCC3)c2n1 CHEMBL4464192 IC50 118.0 nM
COc1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCN(C(=O)CCN)C3)C(=O)N2 CHEMBL2403366 IC50 120.0 nM
Cc1ccc(NC(=O)c2ccc(CN(CCN(C)C)C(=O)CN(C)C)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL4245919 GI50 120.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(N4CCN(Cc5ccccc5)CC4)cc3)c3ncn(CCCO)c3n2)CC1 CHEMBL4467012 IC50 121.0 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4ccc5ccccc5c4)cc3)c12 CHEMBL4071160 IC50 124.0 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccc[nH]2)C(=O)N3)c1)Cc1ccccc1 CHEMBL1980407 pKi 125.89 nM
CC(C)Nc1c(C(N)=O)nnc2cc(-c3ccc(S(C)(=O)=O)cc3)ccc12 CHEMBL2333126 IC50 127.0 nM
Cc1cc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(C)c34)cc2)ccc1N1CCN(C)CC1 CHEMBL4066302 IC50 127.0 nM
NCCCCNc1nc(Nc2ccc(N3CCN(Cc4ccccc4)CC3)cc2)c2ncn(C3CCC(O)C3)c2n1 CHEMBL4483020 IC50 128.0 nM
CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(CCN(C)C)C(C)=O)cc1)c1ccccc1 CHEMBL1272238 IC50 130.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 130.0 nM
Cc1c2ccc(N(C)c3ccnc(Nc4cccc(F)c4)n3)cc2nn1C CHEMBL3114018 IC50 130.0 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)NCCCCc4ccccc4)cc3)c12 CHEMBL4074745 IC50 135.0 nM
CCN(CC)c1cccc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(C)c34)cc2)c1 CHEMBL4073536 IC50 136.0 nM
CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN(C)C)cc1)c1ccccc1 CHEMBL1272290 IC50 137.0 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c12 CHEMBL4079338 IC50 137.0 nM
Cc1ccc(NC(=O)c2ccc(CCl)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL1765715 IC50 139.0 nM
CN(c1ccc2cn(C)nc2c1)c1ccnc(Nc2cccc(F)c2)n1 CHEMBL3114026 IC50 140.0 nM
COc1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCN(C(=O)N1CCOCC1)C3)C(=O)N2 CHEMBL2403370 IC50 150.0 nM
C[C@H]1Cc2c(ncnc2Oc2ccc3c(ccn3C(=O)Nc3cc(C4(C)CC4)[nH]n3)c2)CN1 CHEMBL3746776 IC50 150.0 nM
O=C(Nc1cc(C2CC2)on1)n1ccc2cc(Oc3ncnc4c3CNC4)ccc21 CHEMBL3746122 IC50 150.0 nM
CC(C)CCn1cnc2c(Nc3ccc(O)cc3)nc(N[C@H]3CC[C@H](N)CC3)nc21 CHEMBL4214422 IC50 150.0 nM
O=S1(=O)CC2(OCCO2)c2cc3nccc(Nc4ccc5scnc5c4)c3cc21 CHEMBL4861646 IC50 152.0 nM
NCCCCNc1ccc(Nc2nc(N[C@H]3CC[C@H](N)CC3)nc3c2ncn3C2CCCC2)cc1 CHEMBL5198461 IC50 153.0 nM
CCCCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CC[C@H](N)CC3)nc21 CHEMBL4207053 IC50 154.0 nM
CCN(C)C(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(CCN(C)C)S(C)(=O)=O)cc1)c1ccccc1 CHEMBL1272182 IC50 155.0 nM
CCCCCCn1cnc2c(Nc3ccc(Cl)cc3)nc(N[C@H]3CC[C@H](N)CC3)nc21 CHEMBL4214362 IC50 156.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3cccc(CN4CCOCC4)c3)c3ncn(CCCO)c3n2)CC1 CHEMBL4530617 IC50 156.0 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)NCc4cccs4)cc3)c12 CHEMBL4071997 IC50 157.0 nM
CCN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1967998 pKi 158.49 nM
COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 CHEMBL24828 pKi 158.49 nM
CCN(C(C)=O)c1ccc(Nc2nc(NC3CC3)c3nc[nH]c3n2)cc1 CHEMBL2006564 pKi 158.49 nM
CCN(CCN)C(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc3ccccc23)c1 CHEMBL2004637 pKi 158.49 nM
CCN(C)C(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(CCN(C)C)C(C)=O)cc1)c1ccccc1 CHEMBL1272291 IC50 160.0 nM
CCCCn1cnc2c(Nc3ccccc3)nc(N[C@H]3CC[C@H](N)CC3)nc21 CHEMBL4202703 IC50 160.0 nM
C=CC(=O)NCc1cccc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)c1 CHEMBL4249299 GI50 160.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(NC(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL465015 IC50 164.0 nM
CCCCCNC(=O)Nc1ccc(-c2ccnc3[nH]nc(C)c23)cc1 CHEMBL4063380 IC50 164.0 nM
Cc1ccc(NC(=O)c2ccc(CN(CCN(C)C)C(=O)c3ccno3)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL4237277 GI50 166.0 nM
NCCCCNc1nc(Nc2ccc(CN3CCOCC3)cc2)c2ncn(CCCO)c2n1 CHEMBL4444215 IC50 167.0 nM
Nc1nccc(Oc2ccc(NC(=O)C3(C(=O)Nc4ccc(F)cc4)CC3)cc2F)c1Cl CHEMBL4104302 IC50 172.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1NC(=O)[C@H]1CCCN1 CHEMBL4093614 IC50 174.6 nM
CCN(C)C(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(CCCN(C)C)C(C)=O)cc1)c1ccccc1 CHEMBL1271796 IC50 176.0 nM
CCN(CC)c1ccc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(C)c34)cc2)cc1 CHEMBL4092638 IC50 176.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 180.0 nM
COc1cc(O)c2c(c1)CCC[C@H](O)CC(=O)/C=C/C[C@H](C)OC2=O CHEMBL1651522 IC50 180.0 nM
Nc1ncnc2c1c(-c1cccc(O)c1)cn2C1CCCC1 CHEMBL169390 IC50 180.0 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12 CHEMBL4096271 IC50 182.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccc(Oc4ccc(Br)cn4)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL4564044 IC50 182.0 nM
Cc1ccc(NC(=O)c2ccc(NC(=O)C(C)Cl)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL3642834 IC50 184.8 nM
CC(C)=CCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CC[C@H](N)CC3)nc21 CHEMBL4207048 IC50 187.0 nM
NCCCCNc1nc(Nc2ccc(CN3CCOCC3)cc2)c2ncn(C3CCCC3)c2n1 CHEMBL4212560 IC50 188.0 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F CHEMBL1230020 Kd 190.0 nM
CCCCCCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CC[C@H](N)CC3)nc21 CHEMBL4218779 IC50 195.0 nM
Cc1nc(NC(=O)NC(=O)C2(C)CCOCC2)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5197168 IC50 196.0 nM
N[C@H]1CC[C@H](Nc2nc(Nc3ccccc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL3084839 IC50 196.0 nM
COc1ccc(C2=NNc3cccc4c(OC)ccc2c34)cc1OC CHEMBL1997335 pKi 199.53 nM
Cc1cc(=O)[nH]nc1-c1ccc(NC(=O)Nc2cc(C(F)(F)F)ccc2F)c(Cl)c1 CHEMBL1997892 pKi 199.53 nM
Cc1cc(OCc2ccc(Cl)c(Cl)c2)ccc1CN1CC(C(=O)O)C1 CHEMBL1990223 pKi 199.53 nM
NC(=O)c1ccc2nc(-c3ccc([N+](=O)[O-])o3)cn2c1 CHEMBL1973359 pKi 199.53 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1979690 pKi 199.53 nM
Cc1cc(C)c(/C=C2\C(=O)Nc3ccccc32)[nH]1 CHEMBL276711 IC50 200.0 nM
NCCCNCCCCNCCCNc1ccc(Nc2nc(N[C@H]3CC[C@H](N)CC3)nc3c2ncn3C2CCCC2)cc1 CHEMBL5178263 IC50 203.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cc(O)nc4[nH]nc(C)c34)cc2)c1 CHEMBL4091741 GI50 204.5 nM
COc1cc2ncnc(N3CCN(/C(S)=N\Cc4ccc5c(c4)OCO5)CC3)c2cc1OC CHEMBL102301 IC50 210.0 nM
CNC(=O)c1cc(Oc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2)ccn1 CHEMBL4227505 Kd 210.0 nM
NCCCCNc1nc(Nc2cccc(CN3CCOCC3)c2)c2ncn(C3CCCC3)c2n1 CHEMBL4447937 IC50 211.0 nM
C=CCc1cccc(/C=N/NC(=O)Nc2ccc(Oc3ccnc4cc(OCCCN5CCCCC5)c(OC)cc34)c(F)c2)c1O CHEMBL3764279 IC50 212.3 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cccc(N5CCN(C)CC5)c4)cc3)c12 CHEMBL4104034 IC50 215.0 nM
Cc1nc(NC(=O)NC(=O)C(C)(C)C)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5195204 IC50 216.0 nM
NCCCNCCCCNc1ccc(Nc2nc(N[C@H]3CC[C@H](N)CC3)nc3c2ncn3C2CCCC2)cc1 CHEMBL5172816 IC50 219.0 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 220.0 nM
COc1cc(-c2cnc3c(N4CCOCC4)snc3c2)cc(OC)c1OC CHEMBL3425865 Kd 220.0 nM
Cc1cccc(C)c1/C=C/n1cnc2c(Nc3ccc(P(C)(C)=O)cc3)ncnc21 CHEMBL488840 IC50 221.0 nM
O=C(Nc1ccc(Oc2ncnc3[nH]ncc23)cc1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL2332840 IC50 223.0 nM
NCCCCNc1nc(Nc2ccc(N3CCN(Cc4ccccc4)CC3)cc2)c2ncn(CCCO)c2n1 CHEMBL4445141 IC50 236.0 nM
COc1cc2ncnc(N3CCN(/C(S)=N\Cc4ccccc4)CC3)c2cc1OC CHEMBL319894 IC50 240.0 nM
COc1cc2c(Oc3ccc(NC(=O)NS(=O)(=O)Cc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL4533153 IC50 242.0 nM
CSCCCNC(=O)c1ccc2c(c1)NC(=O)/C2=C\c1[nH]c(C)cc1C CHEMBL3621300 IC50 245.0 nM
CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL2010872 IC50 246.0 nM
COc1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCN(C(C)=O)C3)C(=O)N2 CHEMBL2403367 IC50 250.0 nM
COc1ccc(-n2ccc3cnc(Nc4cc(OC)c(OC)c(OC)c4)nc32)cc1 CHEMBL1975927 pKi 251.19 nM
CCN(CC)CC#Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL2001257 pKi 251.19 nM
CCN(CC)CCNC(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc3ccccc23)c1 CHEMBL1970290 pKi 251.19 nM
CCNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)n2)s1 CHEMBL1983715 pKi 251.19 nM
CC(C)(C)n1nc(-c2ccc(Cl)cc2)c2c(N)ncnc21 CHEMBL406845 pKi 251.19 nM
CNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCNCC4)cc3)n2)s1 CHEMBL1999484 pKi 251.19 nM
Cc1nc(NC(=O)NC(=O)Cc2ccc(F)cc2)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5197530 IC50 256.0 nM
Cn1ccc2c(Oc3ccc(NC(=O)Cc4ccc(C(F)(F)F)c(F)c4)cc3)ncnc21 CHEMBL5394677 IC50 258.3 nM
CC(C)Nc1c(C(N)=O)nnc2cc(N3CCOCC3)ccc12 CHEMBL2333120 IC50 262.0 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL4069008 IC50 262.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCCN4)cc2)no1 CHEMBL4793380 IC50 262.0 nM
COCC1CN(C2CCN(c3cc(OC)c(Nc4ncc(Br)c(Nc5ccc6c(c5P(C)(C)=O)OCCO6)n4)cc3C)CC2)C1 CHEMBL5188373 IC50 266.0 nM
COc1cc(Nc2nc(N[C@H]3CC[C@H](N)CC3)nc3c2ncn3CCC(C)C)cc(OC)c1 CHEMBL4211413 IC50 290.0 nM
c1ccc(Cc2cnc(N3CCN(c4ncnc5ccccc45)CC3)nc2)cc1 CHEMBL1782075 IC50 295.0 nM
COc1cc2ncc(N[C@H]3CC[C@H](O)CC3)nc2cc1OC CHEMBL104466 IC50 299.0 nM
COCC(=O)Oc1ccc2[nH]c(C(=O)c3cc4ccccc4[nH]3)cc2c1 CHEMBL7600 IC50 300.0 nM
CCCc1cc(N2CCNCC2)nc2sc(C(N)=O)c(N)c12 CHEMBL568922 IC50 300.0 nM
CSc1nc(N)cc(Oc2ccc(-c3nnc(Nc4cccc(C(F)(F)F)c4)[nH]3)cc2)n1 CHEMBL3932957 Kd 300.0 nM
Cc1ccccc1NC(=O)Nc1ccc(-c2ccnc3[nH]nc(C)c23)cc1 CHEMBL4060326 IC50 305.0 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4ccc(N(C)C)cc4)cc3)c12 CHEMBL4084878 IC50 309.0 nM
COC(C)(C)C(=O)NC(=O)Nc1ccc(Oc2ccnc(-c3cc(C)no3)c2)c(C)n1 CHEMBL5170451 IC50 311.0 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cccnc4)cc3)c12 CHEMBL4103890 IC50 313.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 pKi 316.23 nM
Nc1ncnc2c1c(-c1cnc3[nH]ccc3c1)nn2C1CCCC1 CHEMBL1081312 pKi 316.23 nM
CC(C)N(CCCN)C(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc3ccccc23)c1 CHEMBL1994318 pKi 316.23 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 316.23 nM
COc1cc2c(cc1F)C(c1ccccc1Cl)=Nc1c(n[nH]c1C)N2 CHEMBL1980391 pKi 316.23 nM
CCN(CC)CCNC(=O)c1ccc(N/C(=C2\C(=O)Nc3cc(C(=O)N(C)CC)ccc32)c2ccccc2)cc1 CHEMBL1271576 IC50 317.0 nM
CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(C(=O)NCCN(CC)CC)cc1)c1ccccc1 CHEMBL1271524 IC50 335.0 nM
Nc1ncnc2c1c(-c1cccc(O)c1)cn2[C@H]1C[C@@H](CO)C1 CHEMBL4858720 IC50 340.0 nM
C=CC(=O)N(CCN(CC)CC)Cc1ccc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc1 CHEMBL4238377 GI50 344.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 350.0 nM
Cc1ccc(NC(=O)c2ccc(CN(CCO)C(=O)c3cccnc3)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL4244561 GI50 353.0 nM
Cc1ccc(NC(=O)c2ccc(CN(CCO)C(=O)CN(C)C)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL4248828 GI50 363.0 nM
CCNc1ncc(-c2ccc(Oc3ccnc(-c4cnn(C)c4)c3)cn2)c(=O)[nH]1 CHEMBL5197156 IC50 364.0 nM
CCN(C)C(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN(C)C)cc1)c1ccccc1 CHEMBL1271470 IC50 367.0 nM
CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CCN(C)C)cc1)c1ccccc1 CHEMBL1271577 IC50 368.0 nM
COC1(C(=O)NC(=O)Nc2ccc(Oc3ccnc(-c4cnn(C)c4)c3)c(C)n2)CC1 CHEMBL5176187 IC50 369.0 nM
CN(C)CCCNC(=O)c1csc2nc(-c3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)cn12 CHEMBL3623375 IC50 370.0 nM
CCC(=O)Nc1cc(Nc2ncc(C(=O)Nc3cc(NC(=O)c4cc(OC)c(OC)c(OC)c4)ccc3C)c(NC)n2)ccc1C CHEMBL4087478 GI50 370.0 nM
CNc1ncc2c(-c3ccc(N4CCN(C)CC4)cc3)nn(CC3CCCC3)c2n1 CHEMBL4218175 IC50 370.0 nM
Nc1nccc(COc2cc(F)c3nc(N[C@@H]4CCCC[C@H]4O)sc3c2)c1Cl CHEMBL4763875 Kd 370.0 nM
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4ccc5ncn(Cc6ccccc6)c5c4)[nH]n3)cc2)CC1 CHEMBL5198364 IC50 370.9 nM
COc1cc2c(Oc3ccc(NC(=O)NN4C(=O)CSC4c4c(F)cccc4F)cc3)ccnc2cc1OC1CCN(C(=O)NC(C)C)CC1 CHEMBL4781937 IC50 384.0 nM
COCC/C(=N\S(=O)(=O)Cc1ccc(Cl)cc1)Nc1ccc(Oc2ccnc3cc(OCCCN4CCOCC4)c(OC)cc23)c(F)c1 CHEMBL4799113 IC50 384.0 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)NCc4ccco4)cc3)c12 CHEMBL4078084 IC50 387.0 nM
COc1cc2c(Oc3ccc(NC(=O)N/N=C/c4ccc(F)cc4F)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL2419669 IC50 390.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1NC(=O)c1cccc2c(N)nccc12 CHEMBL3967980 IC50 393.0 nM
COc1cc2c(Nc3ccc(NC(=O)c4ccccc4)cc3)ncnc2cc1OCCCN1CCOCC1 CHEMBL202721 pKi 398.11 nM
O=C(O)C1CN(Cc2ccc(OCc3cccc(C(F)(F)F)c3)cc2)C1 CHEMBL1971132 pKi 398.11 nM
NC(=O)c1c(OCc2c(F)cc(Br)cc2F)nsc1NC(=O)NCCCCN1CCCC1 CHEMBL253969 pKi 398.11 nM
CC(C)(c1cc(Br)c(O)c(I)c1)c1cc(Br)c(O)c(I)c1 CHEMBL1964382 pKi 398.11 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccc(CO)cc3)cc1)cn2C1CCOC1 CHEMBL1976376 pKi 398.11 nM
Cc1ccc(NCc2ccc(-c3ccc(F)cc3)nc2)cc1 CHEMBL1986899 pKi 398.11 nM
Cc1nc(-c2cnc(NC3CCOCC3)[nH]c2=O)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5190410 IC50 400.0 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4ccccn4)cc3)c12 CHEMBL4085962 IC50 401.0 nM
CC1(C)c2cc(C3CCN(CC4CCOCC4)CC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3735648 IC50 402.0 nM
O=C1Nc2ccc(O)cc2/C1=C/c1ccc[nH]1 CHEMBL393636 IC50 406.0 nM
CCN(C)C(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(CC(=O)N(C)C)S(C)(=O)=O)cc1)c1ccccc1 CHEMBL1271683 IC50 410.0 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4ccn[nH]4)cc3)c12 CHEMBL4085010 IC50 411.0 nM
CCN(C)C(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CCN(C)C)cc1)c1ccccc1 CHEMBL1271631 IC50 420.0 nM
CN1CCN(c2ccc(-n3cc(-c4ccncc4OCC4CCNCC4)cn3)cc2)CC1 CHEMBL3824068 IC50 420.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-n3nc(-c4ccc(OCCN5CCOCC5)cc4)c4c(N)ncnc43)cc2)no1 CHEMBL4101411 IC50 426.0 nM
COc1cc2[nH]c3ncnc(N4CCN(C(=S)NCc5ccc6c(c5)OCO6)CC4)c3c2cc1OC CHEMBL3914378 EC50 428.75 nM
CCN1CCCC(Nc2ccc3c(c2)C(=C(c2ccccc2)c2nc4cc(OC)ccc4[nH]2)C(=O)N3)C1 CHEMBL2086750 IC50 431.0 nM
Cc1nc(-c2cnc(NC(C)C)n(C)c2=O)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5095202 IC50 436.0 nM
COc1cc(O)c2c(c1)/C=C\CCCC(=O)/C=C/C[C@H](C)OC2=O CHEMBL1668420 IC50 450.0 nM
CCCCCCn1cnc2c(Nc3ccc(O)cc3)nc(N[C@H]3CC[C@H](N)CC3)nc21 CHEMBL4206527 IC50 452.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(C(F)(F)F)c34)cc2)c1 CHEMBL4102648 GI50 465.2 nM
COC(C)(C)C(=O)NC(=O)Nc1ccc(Oc2ccnc(-c3cnn(C)c3)c2)c(C)n1 CHEMBL5170609 IC50 466.0 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)NCc4ccccn4)cc3)c12 CHEMBL4092765 IC50 472.0 nM
CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C\Nc1ccc(N(CCCN(C)C)C(C)=O)cc1 CHEMBL1271965 IC50 484.0 nM
COc1cc2nccc(Oc3ccc(NC(NC#N)Nc4ccc(F)cc4)cc3)c2cc1OC CHEMBL179450 IC50 490.0 nM
O=C1Nc2cc(-c3ccc(O)cc3)ccc2C1=Cc1ccc[nH]1 CHEMBL1980329 pKi 501.19 nM
Nc1ncnc2scc(-c3ccccc3)c12 CHEMBL1975212 pKi 501.19 nM
CN(C)c1ccc(Nc2cc(-c3csc(Br)c3)[nH]n2)cc1 CHEMBL1984236 pKi 501.19 nM
Cc1nc(-c2cnc(NC3CCCC3)[nH]c2=O)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5192630 IC50 517.0 nM
COc1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCN(C(=O)c1cnoc1C)C3)C(=O)N2 CHEMBL2403368 IC50 540.0 nM
O=C(Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1)[C@H]1CCCN1 CHEMBL2208034 IC50 546.7 nM
Nc1ncnc2scc(-c3ccc4c(C(=O)Nc5ccccc5)cccc4c3)c12 CHEMBL3288526 IC50 548.6 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cc(O)nc4[nH]nc(C)c34)cc2)c1 CHEMBL4100645 IC50 560.0 nM
CCN(C)C(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(C(=O)O)cc1)c1ccccc1 CHEMBL1272181 IC50 564.0 nM
Cc1nc(NC(=O)NC(=O)C2(C)CC2)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5170039 IC50 593.0 nM
Cc1c2ccncc2c(C)c2c1[nH]c1ccc(O)cc12 CHEMBL26559 IC50 600.0 nM
COCCNS(=O)(=O)c1ccc2c(c1)C(=C(c1ccccc1)c1nc3ccccc3[nH]1)C(=O)N2 CHEMBL2086747 IC50 614.0 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCCCN(C)C)cc2NC3=O)ccc1O CHEMBL1996702 pKi 630.96 nM
COc1c(-c2nc3ccccc3[nH]2)c(O)cc2oc(C)cc(=O)c12 CHEMBL1972355 pKi 630.96 nM
CN(C)CCCCNC(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc3ccccc23)c1 CHEMBL2001451 pKi 630.96 nM
O=C(NN=Cc1cc(Br)c(O)c(Br)c1)Nc1ccccc1 CHEMBL1983575 pKi 630.96 nM
O=C(Nc1ccc(-c2ccc3cn[nH]c3c2)cc1)Nc1cccc(F)c1 CHEMBL1969942 pKi 630.96 nM
CC(C)NC1=NNC(=O)C1=Cc1cc2ccccc2[nH]1 CHEMBL1988692 pKi 630.96 nM
CCN(C)C(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)S(C)(=O)=O)cc1)c1ccccc1 CHEMBL1272127 IC50 640.0 nM
COc1cc(O)c2c(c1)-c1cccc(c1)[C@@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O CHEMBL4453304 IC50 644.0 nM
Cc1ccc(-c2nn(C(C)(C)C)c3ncnc(N)c23)cc1 CHEMBL306380 IC50 657.0 nM
C=CC(=O)Nc1cc(Nc2ncc(C(=O)Nc3cc(NC(=O)c4cc(OC)c(OC)c(OC)c4)ccc3C)c(NC)n2)ccc1C CHEMBL4066104 GI50 670.0 nM
CCN1CCN(Cc2ccc(NC(=O)CNc3ccc(-c4ccc(NC(=O)C5CC5)nc4)cc3)cc2C(F)(F)F)CC1 CHEMBL3805771 IC50 672.0 nM
COC(C)(C)C(=O)NC(=O)Nc1ccc(Oc2ccnc(-c3ccc(C)nc3)c2)c(C)n1 CHEMBL5202851 IC50 674.0 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL1642 EC50 680.24 nM
OCCCCNc1nc(Nc2ccc(Oc3nccs3)cc2)c2ncn(C3CCCC3)c2n1 CHEMBL4451090 IC50 686.0 nM
CCCNC(=O)c1cc(Oc2ccc(NC(=O)c3cc4cccnc4n(-c4ccc(F)cc4)c3=O)cc2)ccn1 CHEMBL4204920 IC50 691.5 nM
Cc1c2cc[n+](C)cc2c(C)c2c1[nH]c1ccc(O)cc12 CHEMBL16699 IC50 700.0 nM
COCC(=O)NC(=O)Nc1ccc(Oc2ccnc(-c3cnn(C)c3)c2)c(C)n1 CHEMBL5191854 IC50 700.0 nM
COC(C)(C)C(=O)NC(=O)Nc1ccc(Oc2ccnc(-c3cnc(C)s3)c2)c(C)n1 CHEMBL5177523 IC50 700.0 nM
COc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Br)cc4)CC3)c2cc1OC CHEMBL323336 IC50 710.0 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)NC4CCC4)cc3)c12 CHEMBL4103897 IC50 732.0 nM
COc1cc2ncnc(N3CCN(C(=O)Nc4ccc(C#N)cc4)CC3)c2cc1OC CHEMBL106966 IC50 770.0 nM
C[C@@H](Oc1ccc2[nH]nc(-c3nc4cc(N5CCN(C)CC5)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl CHEMBL3827178 IC50 781.8 nM
CCNC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN2CCCCC2)cc1)c1ccccc1 CHEMBL1271472 IC50 789.0 nM
CN(CCN)C(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc3ccccc23)c1 CHEMBL1979773 pKi 794.33 nM
CC(C)(C)c1cc(NC(=O)Nc2cccc3ccccc23)n(-c2cccc(C(=O)N(CCN)CCO)c2)n1 CHEMBL1993634 pKi 794.33 nM
CN(Cc1cc(Cl)c(O)c2ncccc12)C1CCCCC1 CHEMBL1982413 pKi 794.33 nM
O=C(O)c1ccc(Nc2ncc3c(n2)-c2ccc(Cl)cc2C(c2c(F)cccc2F)=NC3)cc1 CHEMBL259084 pIC50 794.33 nM
Nc1ncnc2c1c(-c1cccc(OCc3ccccc3)c1)cn2[C@H]1C[C@@H](CN2CCC2)C1 CHEMBL1614712 IC50 800.0 nM
Cc1nc(-c2cnc(N3CCCCC3)[nH]c2=O)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5189828 IC50 843.0 nM
CCCCNS(=O)(=O)c1ccc2c(c1)C(=C(c1ccccc1)c1nc3ccccc3[nH]1)C(=O)N2 CHEMBL2086746 IC50 844.0 nM
CC(=O)Nc1cn2cc(-c3cnc(N)c(OC(C)C(F)(F)F)n3)ccc2n1 CHEMBL3753450 IC50 860.0 nM
COc1cc2ncnc(N3CCN(C(=O)Nc4ccc([N+](=O)[O-])cc4)CC3)c2cc1OC CHEMBL99743 IC50 890.0 nM
CCN(C)C(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN2CCCCC2)cc1)c1ccccc1 CHEMBL496862 IC50 890.0 nM
CCn1nc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(C)CC4)c(C(F)(F)F)c3)ccc2C)c2c(N)ncnc21 CHEMBL3426225 IC50 890.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL1240703 Kd 900.0 nM
Nc1ncnc2c1c(-c1cccc(O)c1)cn2[C@H]1C[C@@H](CN2CCC2)C1 CHEMBL3787112 IC50 900.0 nM
Cc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4ccccc4N4CCN(C)CC4)cc3)c12 CHEMBL4062187 IC50 928.0 nM
COc1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)cc(OC)c1OC CHEMBL201511 IC50 943.0 nM
C[C@@H]1CCNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n21 CHEMBL1933288 IC50 956.0 nM
COC(C)(C)C(=O)NC(=O)Nc1ccc(Oc2ccnc(-c3ccnc(C)c3)c2)c(C)n1 CHEMBL5175832 IC50 966.0 nM
CCCNC(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1Cl CHEMBL406381 IC50 970.0 nM
Cc1nc2c(F)cc(-c3nc(Nc4ccc5c(n4)CCN(CCN(C)C)C5)ncc3F)cc2n1C(C)C CHEMBL4448494 IC50 970.0 nM
CNc1ncc2c(-c3ccc(N4CCN(C)CC4)nc3)nn(CC3CCCC3)c2n1 CHEMBL4208852 IC50 990.0 nM
O=C(c1cc2ccccc2[nH]1)c1cc2cc(O)ccc2[nH]1 CHEMBL7735 IC50 1000.0 nM
CC(C)(C)c1cc(NC(=O)Nc2cccc3ccccc23)n(-c2cccc(C(=O)NCCOCCO)c2)n1 CHEMBL1978271 pKi 1000.0 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 1000.0 nM
O=C(O)C1CN(Cc2ccc(OCc3cccc(C(F)(F)F)c3)cc2Cl)C1 CHEMBL1986265 pKi 1000.0 nM
Oc1cc(O)cc(C=Cc2ccc(O)c(O)c2)c1 CHEMBL1972346 pKi 1000.0 nM
O=c1[nH]cnc2c(Cl)cccc12 CHEMBL1949855 pKi 1000.0 nM
CCC(=O)Nc1ccc(C(=O)N2CCNCC2)c(O)c1 CHEMBL1988141 pKi 1000.0 nM
COCC#Cc1cccc2c1Cc1c(-c3cccs3)n[nH]c1-2 CHEMBL1985206 pKi 1000.0 nM
O=C(NCCNc1cc(-c2cn(-c3ccccc3)nc2-c2cccc(O)c2)ccn1)Nc1cccc(C(F)(F)F)c1 CHEMBL5201911 IC50 1000.0 nM