CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 0.075 nM
CN1CCN(c2ccc3[nH]c(-c4c(N)c5cc(C(=O)NCc6ccccc6)ccc5[nH]c4=O)nc3c2)CC1 CHEMBL526507 IC50 0.1 nM
CN1CCCC(Oc2cccc3[nH]c(=O)c(-c4nc5ccccc5[nH]4)c(N)c23)C1 CHEMBL495749 IC50 0.1 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)c1 CHEMBL196363 pKi 0.1259 nM
CCC1CCN(C)C(Nc2c(-c3nc4ccccc4[nH]3)c(=O)[nH]c3ccccc23)C1 CHEMBL495984 IC50 0.2 nM
COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1CC(=O)Nc1noc(C)c1C CHEMBL2023477 IC50 0.2 nM
CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)n[nH]1 CHEMBL2023485 IC50 0.2 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 0.29 nM
COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1 CHEMBL1908396 Kd 0.29 nM
CN1CCN(c2ccc3[nH]c(-c4c(N)c5c(Cl)cccc5[nH]c4=O)nc3c2)CC1 CHEMBL495762 IC50 0.3 nM
CN1CCN(c2cccc3[nH]c(=O)c(-c4nc5ccccc5[nH]4)c(N)c23)CC1 CHEMBL498551 IC50 0.3 nM
COCCOc1cc2ncnc(Oc3cnn(CC(=O)Nc4cccc(OC)c4)c3)c2cc1OC CHEMBL1940109 IC50 0.3 nM
COc1ccc2c(Oc3ccc(CC(=O)Nc4ncc(C)s4)c(OC)c3)ccnc2c1 CHEMBL2023476 IC50 0.3 nM
CCN(CC)CCCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL1999414 pKi 0.3162 nM
COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1 CHEMBL491473 Kd 0.32 nM
CCN(CC)CCCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)csc12 CHEMBL1996649 pKi 0.3981 nM
COCCOc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5ccc6ccccc6c5)cc4)CC3)c2cc1OCCOC CHEMBL340284 IC50 0.4 nM
COCCOc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5cccc6cnccc56)cc4)CC3)c2cc1OCCOC CHEMBL123928 IC50 0.4 nM
CN1CCN(c2ccc3[nH]c(-c4c(N)c5ccc(F)cc5[nH]c4=O)nc3c2)CC1 CHEMBL498013 IC50 0.4 nM
CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)cn1 CHEMBL1940273 IC50 0.4 nM
CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)no1 CHEMBL2023482 IC50 0.4 nM
O=C1Nc2ccccc2/C1=C/c1c[nH]nc1-c1ccccc1[N+](=O)[O-] CHEMBL2347053 IC50 0.4 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NCCN(C)C CHEMBL13976 IC50 0.5 nM
CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)n[nH]1 CHEMBL2023486 IC50 0.5 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(O)CO)c5)cnc(N)c34)cc2)cc1 CHEMBL1965170 pKi 0.5012 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 pKi 0.5012 nM
CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL1289926 Kd 0.57 nM
CN1CCN(c2ccc3[nH]c(-c4c(N)c5cc(NCc6ccccc6)ccc5[nH]c4=O)nc3c2)CC1 CHEMBL495735 IC50 0.6 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.6 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL5416410 Kd 0.63 nM
CNC(=O)c1ccccc1Sc1ccc2c(C=Cc3ccccn3)n[nH]c2c1 CHEMBL1988437 pKi 0.631 nM
Cc1cccc2[nH]c(=O)c(-c3nc4cc(N5CCN(C)CC5)ccc4[nH]3)c(N)c12 CHEMBL495763 IC50 0.7 nM
CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)cn1 CHEMBL2023118 IC50 0.7 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4ccc(OC(F)F)cc4)cc3)c12 CHEMBL1972220 pKi 0.7943 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 0.7943 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 CHEMBL49120 pKi 0.7943 nM
COc1cccc(NC(=O)Cn2cc(Oc3ncnc4cc(OC)c(OC)cc34)cn2)c1 CHEMBL1940108 IC50 0.8 nM
Nc1nccc(COc2ccc3nc(N[C@H]4CCCC[C@@H]4O)sc3c2)c1Cl CHEMBL4741283 Kd 0.84 nM
O=c1[nH]c2ccccc2c(NCC2CCNCC2)c1-c1nc2ccccc2[nH]1 CHEMBL526285 IC50 0.9 nM
CN1CCN(C(=O)c2ccc3[nH]c(-c4c(N)c5ccccc5[nH]c4=O)nc3c2)CC1 CHEMBL498214 IC50 0.9 nM
COc1cccc(NC(=O)Cc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)c1 CHEMBL1940259 IC50 0.9 nM
CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)cn1 CHEMBL2023117 IC50 0.9 nM
CCN1CCN(c2ccc(Nc3ncc(C)c(Nc4ccc5cn[nH]c5c4)n3)cc2OC)CC1 CHEMBL5184634 IC50 0.9 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 0.96 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NCc1ccncc1 CHEMBL268731 IC50 1.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NCCN1CCCC1 CHEMBL13608 IC50 1.0 nM
COCCOc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5cccc6[nH]ccc56)cc4)CC3)c2cc1OCCOC CHEMBL125277 IC50 1.0 nM
COc1cc2c(cc1OC)-c1n[nH]c(Nc3cccc(C(F)(F)F)c3)c1C2 CHEMBL184948 IC50 1.0 nM
CN(C)CC(=O)N(C)c1ccc2[nH]c(-c3c(N)c4ccccc4[nH]c3=O)nc2c1 CHEMBL495962 IC50 1.0 nM
CN1CCN(c2ccc3[nH]c(-c4c(N)c5cc(F)ccc5[nH]c4=O)nc3c2)CC1 CHEMBL496763 IC50 1.0 nM
COc1cccc(NC(=O)Cn2cc(Oc3ncnc4cc(OCCN5CCCC5)c(OC)cc34)cn2)c1 CHEMBL1940112 IC50 1.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)O)c5)cnc(N)c34)cc2)c1 CHEMBL1989708 pKi 1.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc32)c1C CHEMBL1990885 pKi 1.0 nM
COc1ccc2c(Oc3ccc(CC(=O)Nc4noc(C)c4C)c(OC)c3)ccnc2c1 CHEMBL2023478 IC50 1.0 nM
CCN1C(C)(C)CC(Oc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1(C)C CHEMBL2206278 Kd 1.0 nM
Cn1c(Nc2cccc(C(C)(C)C)c2)nc2cc(Oc3ccnc(-c4ncc(C(F)(F)F)[nH]4)c3)ccc21 CHEMBL3632719 IC50 1.0 nM
CC(=O)Nc1cc(Oc2ccc3c(c2)nc(Nc2cccc(C(C)(C)C)c2)n3C)ccn1 CHEMBL3335371 IC50 1.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 IC50 1.0 nM
OC[C@H](Nc1cnc(-c2cc(Cl)ccc2O)c(-c2ccc3cnccc3c2)c1)c1ccccc1 CHEMBL4067871 IC50 1.0 nM
Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3ccc(F)cc3O)cc12 CHEMBL4075917 IC50 1.0 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12 CHEMBL400402 IC50 1.1 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(C(=O)N4CCNCC4)cc3)nc12 CHEMBL250214 IC50 1.2 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1171837 IC50 1.2 nM
Nc1nccc(COc2ccc3nc(N[C@H]4CCCC[C@H]4O)sc3c2)c1Cl CHEMBL4798876 Kd 1.2 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)(C)O)c5)cnc(N)c34)cc2)cc1 CHEMBL2004290 pKi 1.259 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2ccc(Cl)cc2)c2ncc[nH]2)C(=O)N3)CC1 CHEMBL2086760 IC50 1.3 nM
CCN1CCC(Oc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1 CHEMBL2203434 Kd 1.3 nM
COCC1CN(C2CCN(c3cc(OC)c(Nc4ncc(Br)c(Nc5ccc6c(c5P(C)(C)=O)OCCO6)n4)cc3C)CC2)C1 CHEMBL5188373 IC50 1.3 nM
COCCOc1cc2ncnc(N3CCN(C(=O)Nc4ccc(C(C)(C)C)cc4)CC3)c2cc1OCCOC CHEMBL341258 IC50 1.4 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 1.4 nM
Cc1nc(NC(=O)CN2CCN(C)CC2)sc1-c1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL4794404 GI50 1.4 nM
COc1cc2c(Oc3ccc(NC(=O)c4cc(-c5ccc(C)cc5)ccn4)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL2435999 IC50 1.42 nM
CN1CCN(CC(=O)N(C)c2ccc(N/C(=C3\C(=O)Nc4cc(-n5nccn5)ccc43)c3ccccc3)cc2)CC1 CHEMBL4177014 IC50 1.5 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1 CHEMBL1946170 IC50 1.5 nM
COc1ccc(NC(=O)CC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]c(C)c(C(=O)NCCN3CCCC3)c2C)cc1 CHEMBL3322566 IC50 1.54 nM
COCCOc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5cccc6ncccc56)cc4)CC3)c2cc1OCCOC CHEMBL125811 IC50 1.6 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCOCC5)ccc34)cc2)no1 CHEMBL576982 Kd 1.6 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(S(=O)(=O)NCCN4CCCC4)cc3)nc12 CHEMBL249821 IC50 1.7 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 IC50 1.8 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1cc2cccnc2n(-c2ccc(F)cc2)c1=O CHEMBL4289577 IC50 1.81 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL223360 Kd 1.9 nM
Cc1cc2nc(Nc3ccc(S(=O)(=O)NCCN4CCCC4)cc3)nnc2cc1-c1cc(O)ccc1Cl CHEMBL3651246 IC50 1.9 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3coc4c(C#CCN5CCOCC5)cnc(N)c34)cc2)c1 CHEMBL1983640 pKi 1.995 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NCCN1CCOCC1 CHEMBL13354 IC50 2.0 nM
COCCOc1ccc2c(N3CCN(C(=O)Nc4ccc(Oc5ccc6[nH]ccc6c5)cc4)CC3)ncnc2c1 CHEMBL121829 IC50 2.0 nM
CN1CCN(c2ccc3[nH]c(-c4c(N)c5ccccc5[nH]c4=O)nc3c2)CC1 CHEMBL204427 IC50 2.0 nM
CN1CCN(Cc2ccc3[nH]c(-c4c(N)c5ccccc5[nH]c4=O)nc3c2)CC1 CHEMBL495961 IC50 2.0 nM
CNc1cccc2[nH]c(=O)c(-c3nc4cc(N5CCN(C)CC5)ccc4[nH]3)c(N)c12 CHEMBL496762 IC50 2.0 nM
Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O CHEMBL477772 Kd 2.0 nM
CCN(CC)CCN1CCc2[nH]c(/C=C3\C(=O)Nc4ccc(Cl)cc43)c(C)c2C1=O CHEMBL1278147 IC50 2.0 nM
COCCOc1cc2c(Oc3cnn(CC(=O)Nc4cccc(OC)c4)c3)ncnc2cc1OC CHEMBL1940110 IC50 2.0 nM
COc1cccc(NC(=O)Cn2cc(Oc3ncnc4cc(OC)cc(OC)c34)cn2)c1 CHEMBL1940113 IC50 2.0 nM
COc1cccc(NC(=O)Cn2cc(Oc3ccnc4cc(OC)c(C#N)cc34)cn2)c1 CHEMBL1940114 IC50 2.0 nM
COc1cccc(NC(=O)Cn2cc(Oc3ccnc4cc(OC)c(OC)cc34)cn2)c1 CHEMBL1940115 IC50 2.0 nM
CCc1c[nH]nc1NC(=O)Cc1ccc(Oc2ccnc3cc(OC)ccc23)cc1OC CHEMBL2023484 IC50 2.0 nM
CCn1cc(NC(=O)Cc2ncc(Oc3ccnc4cc(OC)ccc34)cc2OC)cn1 CHEMBL2023495 IC50 2.0 nM
COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C(F)(F)F)on4)c3)c2cc1OC CHEMBL2029988 Kd 2.0 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(N4CCOCC4)nc3)nc12 CHEMBL3651249 IC50 2.1 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cn4c(n3)sc3ccccc34)cc2)no1 CHEMBL575925 Kd 2.2 nM
Cc1cccc(C(=O)Nc2cccc([C@H](C)Nc3cncc(Cl)n3)c2)c1 CHEMBL504075 Kd 2.3 nM
COc1cc2c(Oc3ccc(Nc4nn(C)cc4C(=O)NC4CCCCC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL5197792 Kd 2.3 nM
COCCOc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5ccc(Br)cc5)cc4)CC3)c2cc1OCCOC CHEMBL125805 IC50 2.4 nM
CN1C(C)(C)CC(Oc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1(C)C CHEMBL2206277 Kd 2.5 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ncccc3O)cc2)no1 CHEMBL1079545 Kd 2.6 nM
CNC(=O)c1ncc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(CCO)CC4)c(C(F)(F)F)c3)ccc2C)n1C CHEMBL1784637 IC50 2.6 nM
Cn1cc(-c2ccc(CNc3cc(-c4cnc5cc(OCCCN6CCCC6)ccn45)ncn3)cc2)cn1 CHEMBL5314917 IC50 2.6 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(S(=O)(=O)C4CCNCC4)cc3)nc12 CHEMBL250625 IC50 2.8 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(S(=O)(=O)CCCN4CCCC4)cc3)nc12 CHEMBL399268 IC50 2.9 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(Cl)cc32)c1C CHEMBL13485 IC50 3.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NCC1CCN(C)CC1 CHEMBL13983 IC50 3.0 nM
COc1cc2c(N3CCN(/C(S)=N\Cc4ccc(C(F)(F)F)nc4)CC3)c(C#N)cnc2cc1OCCCN1CCCCC1 CHEMBL364601 IC50 3.0 nM
COc1cc2c(cc1OC)-c1n[nH]c(Nc3cccc(Cl)c3)c1C2 CHEMBL200735 IC50 3.0 nM
COc1cc2c(cc1OC)-c1n[nH]c(Nc3cccc(F)c3)c1C2 CHEMBL120077 IC50 3.0 nM
CN1CCN(c2ccc3[nH]c(-c4c(N)c5cc(F)c(F)cc5[nH]c4=O)nc3c2)CC1 CHEMBL522732 IC50 3.0 nM
CCN(CC)CCN1CCc2[nH]c(/C=C3\C(=O)Nc4ccc(Br)cc43)c(C)c2C1=O CHEMBL1278233 IC50 3.0 nM
Cc1c(/C=C2\C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)N(CCN(C)C)CC2 CHEMBL1278234 IC50 3.0 nM
COc1cc2ncnc(Oc3cnn(CC(=O)Nc4ccc(N(C)C)cn4)c3)c2cc1OC CHEMBL1940107 IC50 3.0 nM
COc1cccc(NC(=O)Cn2cc(Oc3ncnc4cc(OC)c(OCCN5CCCCC5)cc34)cn2)c1 CHEMBL1940111 IC50 3.0 nM
CCn1cc(NC(=O)Cc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)cn1 CHEMBL1940272 IC50 3.0 nM
CCn1cc(NC(=O)Cc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2OC)cn1 CHEMBL2023115 IC50 3.0 nM
CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4ccc(OC)cc34)cc2OC)cn1 CHEMBL2023119 IC50 3.0 nM
CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cn2)cn1 CHEMBL2023800 IC50 3.0 nM
CCOc1cc2nccc(Oc3cnc(CC(=O)Nc4n[nH]c(CC)c4C)c(OC)c3)c2cc1OC CHEMBL2023802 IC50 3.0 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(S(=O)(=O)N(C)CCN4CCCC4)cc3)nc12 CHEMBL250019 IC50 3.1 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccc[nH]2)C(=O)N3)c1)Cc1ccccc1 CHEMBL1980407 pKi 3.162 nM
CNCC#Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL1964441 pKi 3.162 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N2C(=O)CC[C@@H]2CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL4170680 IC50 3.2 nM
Cc1cc(=O)n(-c2ccc(F)cc2)nc1C(=O)Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1 CHEMBL4066684 IC50 3.26 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 3.3 nM
COc1ccc(Cl)c(-c2cc3nnc(Nc4ccc(C(=O)N5CCN(C)CC5)cc4)nc3cc2C)c1 CHEMBL3651202 IC50 3.5 nM
Cc1cc2nc(Nc3ccc(C(=O)N4CCN(C)CC4)cc3)nnc2cc1-c1cc(O)ccc1Cl CHEMBL3651210 IC50 3.7 nM
Nc1nccc(COc2ccc3nc(NC4CCCCC4)sc3c2)c1Cl CHEMBL4788945 Kd 3.8 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\CNc3ccc(F)cc32)c1C CHEMBL5405436 IC50 3.8 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1336 pKi 3.981 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 3.981 nM
O=C(O)CCc1c(/C=C2\C(=O)Nc3ccc(Br)cc32)[nH]c2c1CCCC2 CHEMBL314995 IC50 4.0 nM
CN(C)[C@H]1CCN(c2ccc3[nH]c(-c4c(N)c5ccccc5[nH]c4=O)nc3c2)C1 CHEMBL496150 IC50 4.0 nM
CCN(CC)CCN1CCc2[nH]c(/C=C3\C(=O)Nc4ccc(F)cc43)c(C)c2C1=O CHEMBL1278146 IC50 4.0 nM
Cc1c(/C=C2\C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)N(CCN1CCCC1)CC2 CHEMBL1276890 IC50 4.0 nM
CCn1cc(NC(=O)Cn2cc(Oc3ncnc4cc(OC)c(OC)cc34)cn2)cn1 CHEMBL1940116 IC50 4.0 nM
COc1cccc(CC(=O)Nc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)c1 CHEMBL1940266 IC50 4.0 nM
CCc1cc(NC(=O)Cc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)n[nH]1 CHEMBL1940268 IC50 4.0 nM
COc1cc2ncnc(Oc3ccc(CC(=O)Nc4cnn(C(C)C)c4)cc3)c2cc1OC CHEMBL1940274 IC50 4.0 nM
COc1ccc2c(Oc3ccc(CC(=O)Nc4n[nH]c(C)c4C)c(OC)c3)ccnc2c1 CHEMBL2023483 IC50 4.0 nM
COc1ccc2c(Oc3ccc(CC(=O)Nc4cn(C)nc4C)c(OC)c3)ccnc2c1 CHEMBL2023489 IC50 4.0 nM
CCc1[nH]nc(NC(=O)Cc2ncc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)c1C CHEMBL2023801 IC50 4.0 nM
Nc1nccc(COc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2Cl)c1Cl CHEMBL4798601 Kd 4.1 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N2C(=O)CC[C@H]2CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL4171244 IC50 4.3 nM
COc1cc2c(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCCN1CCCCC1 CHEMBL124660 Kd 4.5 nM
CN1CCN(CC(=O)N(C)c2ccc(N/C(=C3\C(=O)Nc4cc(-c5nnco5)ccc43)c3ccccc3)cc2)CC1 CHEMBL4160821 IC50 4.5 nM
O=C(Nc1ccc(Oc2ccnc3[nH]ccc23)c(F)c1)c1nnn(-c2ccc(F)cc2)c1C(F)(F)F CHEMBL3774451 IC50 4.57 nM
Nc1ncnc2scc(-c3ccc4c(C(=O)Nc5ccccc5)cccc4c3)c12 CHEMBL3288526 IC50 4.6 nM
COc1cc(Nc2ncc(C)c(Nc3ccc4cn[nH]c4c3)n2)ccc1N1CCN(C)CC1 CHEMBL5173185 IC50 4.6 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(Br)cc32)c1C CHEMBL13629 IC50 5.0 nM
COc1cc2c(N3CCN(/C(S)=N\c4ccc(C#N)cc4)CC3)c(C#N)cnc2cc1OCCCN1CCCCC1 CHEMBL186719 IC50 5.0 nM
COc1cc2c(N3CCN(/C(S)=N\Cc4ccc5c(c4)OCO5)CC3)ncnc2cc1OCCN1CCCC1 CHEMBL184078 IC50 5.0 nM
COc1cc2c(N3CCN(/C(S)=N\Cc4ccc(C(F)(F)F)nc4)CC3)ncnc2cc1OCCCN1CCOCC1 CHEMBL360756 IC50 5.0 nM
COc1cc2c(cc1OC)-c1n[nH]c(Nc3cccc(Br)c3)c1C2 CHEMBL120862 IC50 5.0 nM
Nc1c(-c2nc3cc(N4CCOCC4)ccc3[nH]2)c(=O)[nH]c2ccccc12 CHEMBL204426 IC50 5.0 nM
CN1CCCN(c2ccc3[nH]c(-c4c(N)c5ccccc5[nH]c4=O)nc3c2)CC1 CHEMBL523071 IC50 5.0 nM
Nc1c(-c2nc3cc(OCCN4CCOCC4)ccc3[nH]2)c(=O)[nH]c2ccccc12 CHEMBL526658 IC50 5.0 nM
CN1CCN(c2ccc3[nH]c(-c4c(N)c5c(F)cc(F)cc5[nH]c4=O)nc3c2)CC1 CHEMBL498347 IC50 5.0 nM
Cc1c(/C=C2\C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)N(CCN1CCOCC1)CCC2 CHEMBL1277071 IC50 5.0 nM
COc1cc2ncnc(Oc3ccc(CC(=O)Nc4ccc(N(C)C)cn4)cc3)c2cc1OC CHEMBL1940118 IC50 5.0 nM
COc1ccc2nccc(Oc3ccc(CC(=O)Nc4noc(C)c4C)c(OC)c3)c2c1 CHEMBL2023479 IC50 5.0 nM
COc1cc(Oc2ccnc3ccc(F)cc23)ccc1CC(=O)Nc1noc(C)c1C CHEMBL2023481 IC50 5.0 nM
COc1ccc2c(Oc3ccc(CC(=O)Nc4cnn(C)c4)c(OC)c3)ccnc2c1 CHEMBL2023492 IC50 5.0 nM
COc1ccc2c(Oc3ccc(CC(=O)Nc4cc(C)nn4C)c(OC)c3)ccnc2c1 CHEMBL2023493 IC50 5.0 nM
COc1ccc2c(Oc3ccc(CC(=O)Nc4cc(C)cc(CN(C)C)c4)c(OC)c3)ccnc2c1 CHEMBL2023494 IC50 5.0 nM
COc1cc2ncnc(Oc3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c2cc1OC CHEMBL2018882 IC50 5.0 nM
CCC(=O)NCC1CCN(c2ccc(NC(=O)Nc3cccc(Oc4ccnc5cc(OC)c(OC)cc45)c3)cc2C(F)(F)F)CC1 CHEMBL4445808 GI50 5.0 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3cccc(C(=O)NCCN(C)C)c3)nc12 CHEMBL3651228 IC50 5.3 nM
CN1CCN(CC(=O)N(C)c2ccc(N/C(=C3\C(=O)Nc4cc(-c5ncon5)ccc43)c3ccccc3)cc2)CC1 CHEMBL4165331 IC50 5.3 nM
Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c2)n(C)n1 CHEMBL2348996 IC50 5.5 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(C#Cc4cncc(N5CCOCC5)c4)c3)cc2C(F)(F)F)CC1 CHEMBL4091628 IC50 5.5 nM
COc1ccc(N(C)c2nc(C)nc3ccccc23)cc1 CHEMBL492399 IC50 5.6 nM
Nc1nccc(COc2ccc3nc(N[C@@H]4CCCC[C@@H]4O)sc3c2)c1Cl CHEMBL4756510 Kd 5.6 nM
Cc1cc2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2cc1-c1cc(O)ccc1Cl CHEMBL3651257 IC50 5.7 nM
COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(-c5cnn(C)c5)cc4c3N(C)C2=O)c1F CHEMBL4871581 IC50 5.7 nM
Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4c3)c2)n(C)n1 CHEMBL2409779 IC50 5.9 nM
Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCC4CCCC4)cc3)nnc2c1 CHEMBL3651296 IC50 5.9 nM
Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1 CHEMBL436137 IC50 5.9 nM
O=C(Cn1cc(Nc2nncc3cc(OCCCN4CCC[C@@H]4CO)ccc23)cn1)Nc1cccc(F)c1F CHEMBL253968 IC50 6.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1N1Cc2cnc(N)nc2N(C)C1=O CHEMBL459850 EC50 6.0 nM
COc1cc2ncnc(Nc3cnn(CC(=O)Nc4ccc(N(C)C)cc4)c3)c2cc1OC CHEMBL1940105 IC50 6.0 nM
CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(F)ccc34)cc2OC)cn1 CHEMBL2023474 IC50 6.0 nM
COc1cc(Oc2ccnc3cc(F)ccc23)ccc1CC(=O)Nc1noc(C)c1C CHEMBL2023480 IC50 6.0 nM
COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1CC(=O)Nc1cn(C)nc1C CHEMBL2023488 IC50 6.0 nM
Cn1c(Nc2ccc(C(F)(F)F)cc2)nc2cc(Oc3ccnc(-c4ncc(C(F)(F)F)[nH]4)c3)ccc21 CHEMBL558752 IC50 6.0 nM
Cc1ccc(Cl)cc1-c1cc2nnc(Nc3ccc(C(=O)N4CCN(C)CC4)cc3)nc2cc1C CHEMBL3651206 IC50 6.0 nM
Cc1ccoc1C(=O)Nc1cccc(C#Cc2cncc(C(=O)N=S(C)(C)=O)c2)c1 CHEMBL3917187 IC50 6.0 nM
Cc1cccc(C(=O)Nc2cccc(C#Cc3cncc(C(=O)N=S(=O)(CCCO)CCCO)c3)c2)c1 CHEMBL3983308 IC50 6.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cncc4[nH]nc(N)c34)c3ccccc23)c1 CHEMBL3920239 IC50 6.7 nM
Nc1nccc(COc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2F)c1Cl CHEMBL4795462 Kd 6.7 nM
Cc1cnc(Nc2ccc(N3CCOCC3)cc2)nc1Nc1ccc2cn[nH]c2c1 CHEMBL5176371 IC50 6.9 nM
CN1CCN(c2ccc3[nH]c(-c4c(N)c5cc(N)ccc5[nH]c4=O)nc3c2)CC1 CHEMBL496764 IC50 7.0 nM
CN1CCN(c2ccc3[nH]c(-c4c(N)c5cc(N(C)C)ccc5[nH]c4=O)nc3c2)CC1 CHEMBL495529 IC50 7.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc4ccccc4cn3)cc2)no1 CHEMBL1081509 Kd 7.0 nM
CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4ccc(F)cc34)cc2OC)cn1 CHEMBL2023475 IC50 7.0 nM
CCc1cccc(NC(=O)c2cccc(N3CCc4c(cnc5ccsc45)C3)c2)c1 CHEMBL3966912 IC50 7.0 nM
Cc1ccc(F)c(C(=O)Nc2cccc(C#Cc3cc(C(=O)N=S(C)(C)=O)cnc3N)c2)c1 CHEMBL3938643 IC50 7.0 nM
Cc1cn(-c2cccc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)c2)cn1 CHEMBL2311808 Kd 7.2 nM
COc1ccc(Nc2nc(C)nc3c(Cc4ccccc4)cn(C)c23)cc1 CHEMBL4099682 IC50 7.2 nM
Cc1cc2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2cc1-c1cccc(O)c1 CHEMBL3651217 IC50 7.4 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(Br)cc21 CHEMBL2430265 IC50 7.6 nM
CCN1CCN(c2ccc(Nc3ncc(C)c(Nc4ccc5cn[nH]c5c4)n3)cc2)CC1 CHEMBL5208704 IC50 7.6 nM
COc1ccc2c(c1)CCCN2c1nc(C)nc2ccccc12 CHEMBL2420866 IC50 7.8 nM
CNC(=O)c1cccc2cc(Oc3ccnc(NC(=O)c4ccc(N5CCN(CCO)CC5)cc4)c3)ccc12 CHEMBL4278642 IC50 7.8 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 pKi 7.943 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCCCCCCCCN)cnc(N)c34)cc2)c1 CHEMBL1978166 pKi 7.943 nM
Nc1c(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)cnc2c(-c3ccc4c(c3)OCO4)cnn12 CHEMBL1977134 pKi 7.943 nM
CN1CCN(c2ccc3[nH]c(-c4c(N)c5cc(Cl)ccc5[nH]c4=O)nc3c2)CC1 CHEMBL523745 IC50 8.0 nM
Cc1c(/C=C2\C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)N(C[C@H](O)CN1CCOCC1)CC2 CHEMBL1276980 IC50 8.0 nM
CSCCCNC(=O)c1ccc2c(c1)/C(=C/c1[nH]c(C)cc1C)C(=O)N2 CHEMBL3621299 IC50 8.0 nM
Cc1cc(-c2c(Cl)ccc(O)c2Cl)cc2nnc(Nc3ccc(S(=O)(=O)NCCN4CCCC4)cc3)nc12 CHEMBL400303 IC50 8.0 nM
Cc1cccc(NC(=O)c2cccc(C#Cc3cc(C(=O)N=S(=O)(CCCO)CCCO)cnc3N)c2)c1 CHEMBL3900571 IC50 8.0 nM
COCCOc1cc2ncnc(N3CCN(c4ncc(Cc5ccccc5)cn4)CC3)c2cc1OCCOC CHEMBL4205999 Kd 8.0 nM
COCCOc1cc(F)c2c(Nc3ccc(NC(=O)Cn4cc(C(C)C)nn4)cc3)ncnc2c1 CHEMBL4216473 GI50 8.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cc(C)nc4noc(N)c34)cc2)c1 CHEMBL4243470 IC50 8.0 nM
CN1CCN(Cc2ccc(NC(=O)CCSc3ccc4c(/C=C/c5ccccn5)n[nH]c4c3)cc2C(F)(F)F)CC1 CHEMBL4439424 GI50 8.0 nM
COc1ccc(NC(=O)CC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]c(C)c(C(=O)O)c2C)cc1 CHEMBL3322565 IC50 8.1 nM
COc1ccc(N(C)c2nc(N)nc3c(Cc4ccccc4)c[nH]c23)cc1 CHEMBL4099329 IC50 8.1 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn(-c4ccc(OCCN5CCOCC5)cc4Cl)nn3)cc2)no1 CHEMBL4645320 Kd 8.1 nM
Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)sc4n3)c2)n(C)n1 CHEMBL2409781 IC50 8.3 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nc(-c2cccnc2)cs1 CHEMBL1908391 Kd 8.4 nM
Cc1cn(-c2cc(F)cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)c2)cn1 CHEMBL2311807 Kd 8.5 nM
COCCOc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5ccc6[nH]ccc6c5)cc4)CC3)c2cc1OC CHEMBL124949 IC50 9.0 nM
COc1cc2c(cc1OC)-c1n[nH]c(Nc3ccccc3)c1C2 CHEMBL432219 IC50 9.0 nM
COc1ccc2c(c1)-c1n[nH]c(Nc3ccccc3)c1C2 CHEMBL371949 IC50 9.0 nM
CNc1ccc2c(N)c(-c3nc4cc(N5CCN(C)CC5)ccc4[nH]3)c(=O)[nH]c2c1 CHEMBL449593 IC50 9.0 nM
COc1cccc(NC(=O)NCc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)c1 CHEMBL1940262 IC50 9.0 nM
COc1ccc2c(Oc3ccc(CC(=O)Nc4cnn(C)c4C)c(OC)c3)ccnc2c1 CHEMBL2023491 IC50 9.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3cccc(C(F)(F)F)c3)c2)c1 CHEMBL3920861 IC50 9.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3cccc(OC)c3)c2)c1 CHEMBL3933295 IC50 9.0 nM
CCN(CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C)CCOCCOCCNC(=O)c1cc(OCc2cn(CCCCN3C[C@@H]4C[C@H]3C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N4)nn2)cc(OCc2cn(CCCCN3C[C@@H]4C[C@H]3C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N4)nn2)c1 CHEMBL4066412 IC50 9.0 nM
CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc21 CHEMBL572881 Kd 9.1 nM
Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(S(=O)(=O)NCCN4CCCC4)cc3)nnc2c1 CHEMBL231218 IC50 9.3 nM
Cc1ccc(NC(=O)c2ccc3c(c2)CC[C@@H]3N2CCN(C)CC2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL3690082 IC50 9.6 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(-n2c(C)ccc2CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL4644718 IC50 9.9 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(-c4ccccc4)ccc32)c(C)c1CCC(=O)O CHEMBL149201 IC50 10.0 nM
CCOc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5ccccc5)cc4)CC3)c2cc1OC CHEMBL102911 IC50 10.0 nM
COCCOc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5ccccc5)cc4)CC3)c2cc1OC CHEMBL339685 IC50 10.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NCCn1cncn1 CHEMBL267293 IC50 10.0 nM
COCCOc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5ccccc5)cc4)CC3)c2cc1OCCOC CHEMBL125717 IC50 10.0 nM
COc1cc2c(N3CCN(/C(S)=N\Cc4ccc(-c5ccccc5)nc4)CC3)c(C#N)cnc2cc1OCCCN1CCCCC1 CHEMBL184642 IC50 10.0 nM
COc1cccc(Nc2[nH]nc3c2Cc2cc(OC)c(OC)cc2-3)c1 CHEMBL120634 IC50 10.0 nM
Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2ccccc12 CHEMBL383417 IC50 10.0 nM
Cc1c(/C=C2\C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)N(CCN1CCOCC1)CC2 CHEMBL1276891 IC50 10.0 nM
CCN(CC)CCN1CCCc2[nH]c(/C=C3\C(=O)Nc4ccc(F)cc43)c(C)c2C1=O CHEMBL1276981 IC50 10.0 nM
COc1cc2ncnc(Nc3cnn(CC(=O)Nc4cccc(F)c4)c3)c2cc1OC CHEMBL1940103 IC50 10.0 nM
COc1cccc(NC(=O)Cn2cc(Nc3ncnc4cc(OC)c(OC)cc34)cn2)c1 CHEMBL1940104 IC50 10.0 nM
COc1cccc(NC(=O)Cc2ccc(Nc3ncnc4cc(OC)c(OC)cc34)cc2)c1 CHEMBL1940260 IC50 10.0 nM
CCn1ccc(NC(=O)Cc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)n1 CHEMBL1940269 IC50 10.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3ccc(OCCCn4cccc4)c4[nH]nc(N)c34)cc2)c1 CHEMBL2007266 pKi 10.0 nM
COc1cccc(OC)c1CNc1nc(NC2CCCCC2)nc2ccc(Cl)cc12 CHEMBL1996646 pKi 10.0 nM
COc1cc2nccc(Oc3ccc(CC(=O)Nc4cn(C)nc4C)cc3)c2cc1OC CHEMBL2023490 IC50 10.0 nM
CNC(=O)c1cc(Oc2ccc3c(c2)nc(Nc2cccc(C(C)(C)C)c2)n3C)ccn1 CHEMBL470808 IC50 10.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3nsc(NC(=O)NCCCN4CCOCC4)c3C(N)=O)cc2)c1 CHEMBL3696074 IC50 10.0 nM
Cc1ccc(NC(=O)Nc2ccc(-c3nsc(NC(=O)NCCCC(=O)O)c3C(N)=O)cc2)cc1 CHEMBL3696083 IC50 10.0 nM
CCc1cccc(NC(=O)c2cccc(N3CCc4c(cnc5ccccc45)C3)c2)c1 CHEMBL3911073 IC50 10.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3cccc(C)c3)c2)c1 CHEMBL3970053 IC50 10.0 nM
CCc1cccc(NC(=O)Nc2ccc(-c3cc4ccccc4n3C(N)=O)cc2)c1 CHEMBL3895384 IC50 10.0 nM
COC(=O)c1ccc2cc(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)n(C(N)=O)c2c1 CHEMBL3893131 IC50 10.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2180602 IC50 10.1 nM
COc1ccc(N(C)c2nc(C)nc3c(Cc4ccccc4)cn(C)c23)cc1 CHEMBL4060996 IC50 10.3 nM
COC(=O)c1cccc(Nc2[nH]nc3c2Cc2cc(OC)c(OC)cc2-3)c1 CHEMBL332375 IC50 11.0 nM
Cc1c(/C=C2\C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)N(C[C@H](O)CN1CCOCC1)CCC2 CHEMBL1277072 IC50 11.0 nM
CC(C)c1cccc(NC(=O)c2cccc(N3CCc4c(cnc5cc(CO)c(CO)cc45)C3)c2)c1 CHEMBL3899614 IC50 11.0 nM
Cc1ccoc1C(=O)Nc1cccc(C#Cc2cc(C(=O)N=S(C)(C)=O)cnc2N)c1 CHEMBL3978649 IC50 11.0 nM
Cc1ccc(NC(=O)Nc2ccc(-c3cc4ccccc4n3C(N)=O)cc2)cc1 CHEMBL3908397 IC50 11.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(-n2cccc2CN(C)C)cc1)c1ccccc1 CHEMBL4069394 IC50 11.0 nM
CC(=O)Nc1cc(-c2c(C)cccc2C)cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12 CHEMBL231251 IC50 11.5 nM
COCCOc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5ccc(C(C)(C)C)cc5)cc4)CC3)c2cc1OCCOC CHEMBL125721 IC50 12.0 nM
COc1cc2c(cc1OC)-c1n[nH]c(Nc3cccc(C)c3)c1C2 CHEMBL331760 IC50 12.0 nM
Cc1cc2nc(-c3c(N)c4ccccc4[nH]c3=O)[nH]c2cc1C CHEMBL498206 IC50 12.0 nM
Cc1cc(NC(=O)c2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc(-n2cnc(C)c2)c1 CHEMBL2311806 Kd 12.0 nM
Cc1ccc(NC(=O)c2ccc3c(c2)CCC3N2CCNCC2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL3690074 IC50 12.0 nM
Cc1ccc(NC(=O)Nc2ccc(-c3nsc(NC(=O)NCCCN4CCOCC4)c3C(N)=O)cc2)cc1 CHEMBL3696076 IC50 12.0 nM
Cc1ccc(NC(=O)Nc2ccc(-c3nsc(NC(=O)NCCCN4CCCC4)c3C(N)=O)cc2)cc1 CHEMBL3696095 IC50 12.0 nM
COc1cccc(NC(=O)Nc2ccc(-c3cc4ccccc4n3C(N)=O)cc2)c1 CHEMBL3911854 IC50 12.0 nM
CN1CCN(CC(=O)N(C)c2ccc(N/C(=C3\C(=O)Nc4cc(-c5ccco5)ccc43)c3ccccc3)cc2)CC1 CHEMBL4172546 IC50 12.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(Cl)cc21 CHEMBL2430264 IC50 12.1 nM
C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1 CHEMBL553 IC50 12.2 nM
COc1ccc(N(C)c2ncnc3occ(C)c23)cc1 CHEMBL4250191 IC50 12.3 nM
Cc1[nH]c2c(c1C(=O)NCCO)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430262 IC50 12.7 nM
CCN(CC)CCN1CCCCc2[nH]c(/C=C3\C(=O)Nc4ccc(F)cc43)c(C)c2C1=O CHEMBL1277161 IC50 13.0 nM
Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)ccc2C)n(C)n1 CHEMBL2180604 IC50 13.0 nM
Cc1ccc(NC(=O)c2ccc3c(c2)CCC3N2CCN(C)CC2)cc1Nc1nccc(-c2cncnc2)n1 CHEMBL3690079 IC50 13.0 nM
Cc1ccc(NC(=O)Nc2ccc(-c3nsc(NC(=O)NCCCO)c3C(N)=O)cc2)cc1 CHEMBL3696084 IC50 13.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)Nc3cccc(C)c3)c2)c1 CHEMBL3925180 IC50 13.0 nM
Cc1ccoc1C(=O)Nc1cccc(C#Cc2cncc(C(=O)N=S(C)(=O)CCCO)c2)c1 CHEMBL3897137 IC50 13.0 nM
Cc1ccoc1C(=O)Nc1cccc(C#Cc2cncc(C(=O)N=[S@](C)(=O)CCCO)c2)c1 CHEMBL4107561 IC50 13.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3ccc(OC)c(OC)c3)c2)c1 CHEMBL3957336 IC50 13.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(C(=O)Nc3cccc(C)c3)c2)c1 CHEMBL3911919 IC50 13.0 nM
CN1CCN(CC(=O)N(C)c2ccc(N/C(=C3\C(=O)Nc4cc(-c5nnn(C)n5)ccc43)c3ccccc3)cc2)CC1 CHEMBL4175951 IC50 13.0 nM
Cc1[nH]c2c(c1C(=O)NCCN1CCOCC1)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430258 IC50 13.2 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc([N+](=O)[O-])cc21 CHEMBL2430254 IC50 13.3 nM
CN1CCN(c2ccc3[nH]c(-c4c(N)c5cccc(F)c5[nH]c4=O)nc3c2)CC1 CHEMBL526836 IC50 14.0 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL941 Kd 14.0 nM
Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1 CHEMBL2409778 IC50 14.0 nM
Cc1ccc(C(=O)N2CCC(Oc3cc(NC(=O)c4ccc(CN5CCN(C)CC5)c(C(F)(F)F)c4)ccc3C)CC2)cn1 CHEMBL3939150 GI50 14.0 nM
O=C(Nc1cccc(C(F)(F)F)c1)c1cccc(N2CCc3c(cnc4ccccc34)C2)c1 CHEMBL3937330 IC50 14.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)Nc3cc(C)ccc3F)c2)c1 CHEMBL3915272 IC50 14.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cc4ccccc4n3C(N)=O)cc2)c1 CHEMBL3944202 IC50 14.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N2C(=O)CC[C@@H]2CN(C)C)cc1)c1ccccc1 CHEMBL4162743 IC50 14.0 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(OCCO)nc(N2CCOCC2)c1 CHEMBL4583691 Kd 14.0 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(C(=O)NCCN4CCCC4)o3)nc12 CHEMBL3651225 IC50 14.4 nM
O=C(Nc1cccc(Oc2ccc3nccn3n2)c1)c1cccc(C(F)(F)F)c1 CHEMBL2206666 IC50 15.0 nM
CCN1CCN(C2CCc3cc(C(=O)Nc4ccc(C)c(Nc5nccc(-c6cccnc6)n5)c4)ccc32)CC1 CHEMBL3690075 IC50 15.0 nM
Cc1ccc(NC(=O)c2ccc3c(c2)CCC3N2CCC(N(C)C)C2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL3690080 IC50 15.0 nM
Cc1cc(-c2c(Cl)cccc2Cl)cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12 CHEMBL230686 IC50 15.0 nM
COC(=O)c1cncc2c1CCN(c1cccc(C(=O)Nc3cccc(C(C)C)c3)c1)C2 CHEMBL3644553 IC50 15.0 nM
CC(C)c1cccc(NC(=O)c2cccc(N3CCc4c(cnc5ccccc45)C3)c2)c1 CHEMBL3984316 IC50 15.0 nM
Cc1ccoc1C(=O)Nc1cccc(C#Cc2cc(C(=O)N=S3(=O)CCCC3)cnc2N)c1 CHEMBL3914411 IC50 15.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3ccc(Cl)c(C(F)(F)F)c3)c2)c1 CHEMBL3963696 IC50 15.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc2c(c1)N(C(=O)Cn1cncn1)CC2)c1ccccc1 CHEMBL4172155 IC50 15.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc2c(c1)N(C(=O)CN(C)C)CC2)c1ccccc1 CHEMBL4166319 IC50 15.0 nM
CNC(=O)c1cc(COc2nnc(Nc3ccc(Cl)cc3)c3ccoc23)ccn1 CHEMBL2079588 IC50 15.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(C)cc21 CHEMBL2430266 IC50 15.6 nM
Cc1cccc(C)c1-c1cc(NS(C)(=O)=O)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1 CHEMBL390479 IC50 15.7 nM
CC(C)Nc1nccc(Nc2ncc(-c3ccccc3)s2)n1 CHEMBL2002432 pKi 15.85 nM
Cc1cnc(Nc2ccc(C(=O)NCCN3CCOCC3)cc2)nc1Nc1ccc2cn[nH]c2c1 CHEMBL5206707 IC50 15.9 nM
Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1 CHEMBL255863 Kd 16.0 nM
Cc1cccc(NC(=O)c2cccc(N3CCc4c(cnc5ccccc45)C3)c2)c1 CHEMBL3895520 IC50 16.0 nM
CC(C)c1ccc(NC(=O)c2cccc(N3CCc4c(cnc5ccccc45)C3)c2)cc1 CHEMBL3950471 IC50 16.0 nM
Cc1ccoc1C(=O)Nc1cccc(C#Cc2cc(C(=O)N=S(=O)(CCCO)CCCO)cnc2N)c1 CHEMBL3924505 IC50 16.0 nM
CC(C)c1cccc(NC(=O)Nc2ccc(-c3cc4ccccc4n3C(N)=O)cc2)c1 CHEMBL3968343 IC50 16.0 nM
CCN(CC)CCN1Cc2[nH]c(/C=C3\C(=O)Nc4ccc(Br)cc43)c(C)c2C1=O CHEMBL5173625 IC50 16.1 nM
C#Cc1cccc(Nc2nc(C)nc3oc(C)cc23)c1 CHEMBL3297892 IC50 16.2 nM
COc1cc2c(Oc3ccc(NC(=O)c4nnn(-c5ccc(F)cc5)c4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCCC1 CHEMBL3343366 IC50 16.3 nM
Cc1cccc(C)c1-c1cc(C)c2nc(Nc3cccc(S(N)(=O)=O)c3)nnc2c1 CHEMBL218597 IC50 16.3 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3ccc(OCCCN4CCCC4)c4[nH]nc(N)c34)c3ccccc23)c1 CHEMBL3892076 IC50 16.3 nM
CC(C)(c1cc(NC(=O)Nc2ccc(-c3cc(-c4ccc(OCCN5CCOCC5)cc4)[nH]n3)cc2)no1)C(F)(F)F CHEMBL5407194 IC50 16.3 nM
Cc1cnc(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)cc2)nc1Nc1ccc2cn[nH]c2c1 CHEMBL5182087 IC50 16.7 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccccc32)c1C CHEMBL275117 IC50 17.0 nM
COc1cc2c(cc1OC)-c1[nH]nc(-c3ccccc3)c1C2 CHEMBL121161 IC50 17.0 nM
Cc1ccc(NC(=O)c2ccc3c(c2)CCC3N2CCN(C)CC2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL3690072 IC50 17.0 nM
COc1ccc(Nc2ncc3c(n2)CCN(C(=O)c2cccnc2)C3)cc1 CHEMBL3952249 IC50 17.0 nM
Cc1[nH]c2c(c1C(=O)NCCCN1CCOCC1)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430248 IC50 18.0 nM
Cc1ccc(NC(=O)c2ccc3c(c2)CCC3N2CCN(C(C)C)CC2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL3690076 IC50 18.0 nM
CC(C)c1ccc(NC(=O)c2cccc(N3CCc4c(cnc5cc(CO)c(CO)cc45)C3)c2)cc1 CHEMBL3890120 IC50 18.0 nM
Cc1ccoc1C(=O)Nc1cccc(C#Cc2cncc(C(=O)N=[S@@](C)(=O)CCCO)c2)c1 CHEMBL3909723 IC50 18.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(C(=O)Nc3cc(C(C)(C)C)on3)c2)c1 CHEMBL3985051 IC50 18.0 nM
CN(C)CCCc1cccc(Nc2ncc3c(n2)-c2ccc(Cl)cc2NC(=S)C3)c1 CHEMBL1945170 IC50 19.0 nM
Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)c2)n(C)n1 CHEMBL2409775 IC50 19.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1NC(=O)CCN1CCN(C)CC1 CHEMBL3288854 Ki 19.0 nM
Cc1cccc(NC(=O)Nc2cccc(C#Cc3cncc(C(=O)N=S(C)(C)=O)c3)c2)c1 CHEMBL3980266 IC50 19.0 nM
Cc1ccc(NC(=O)Nc2cccc(C#Cc3cncc(C(=O)N=S(C)(C)=O)c3)c2)cc1 CHEMBL3910155 IC50 19.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3cc(C(F)(F)F)ccc3F)c2)c1 CHEMBL3918345 IC50 19.0 nM
COc1cc(Nc2ncc3c(n2)CCN(C(=O)c2cc(C)nn2C)C3)cc(OC)c1OC CHEMBL3976229 IC50 19.0 nM
NC(=O)n1c(-c2ccc(NC(=O)Nc3ccc(F)c(Cl)c3)cc2)cc2ccccc21 CHEMBL3938792 IC50 19.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc2c(c1)N(C(=O)CN1CCCC1=O)CC2)c1ccccc1 CHEMBL4165455 IC50 19.0 nM
Nc1nccc(COc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2)c1Cl CHEMBL4759047 Kd 19.0 nM
CCN(CC)CC(O)CNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430250 IC50 19.3 nM
Cc1[nH]c2c(c1C(=O)NCCN1CCCCC1)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430259 IC50 19.4 nM
COc1cc2c(Oc3ccc(NC(=O)c4cc5cccnc5n(-c5ccc(F)cc5)c4=O)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4279457 IC50 19.46 nM
Nc1n[nH]c2c(OCCCn3cccc3)ccc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12 CHEMBL1965387 pKi 19.95 nM
O=C(O)CCc1c(/C=C2\C(=O)Nc3ccc(C(=O)O)cc32)[nH]c2c1CCCC2 CHEMBL431996 IC50 20.0 nM
COCCOc1cc2c(N3CCN(C(=O)Nc4ccc(Oc5ccccc5)cc4)CC3)ncnc2cc1OC CHEMBL144725 IC50 20.0 nM
CCOCCOc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5ccccc5)cc4)CC3)c2cc1OC CHEMBL343209 IC50 20.0 nM
COCCOc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5cccc6c5CCN6)cc4)CC3)c2cc1OCCOC CHEMBL340157 IC50 20.0 nM
COc1cc2c(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCCN1CCOCC1 CHEMBL125898 IC50 20.0 nM
COc1cc2ncnc(N3CCN(C(=O)Nc4ccc(C(C)C)cc4)CC3)c2cc1OC CHEMBL104067 IC50 20.0 nM
COc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5ccc(C)cc5)cc4)CC3)c2cc1OC CHEMBL105227 IC50 20.0 nM
COc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5ccc(Cl)cc5)cc4)CC3)c2cc1OC CHEMBL105183 IC50 20.0 nM
COCC(=O)Oc1ccc2[nH]c(C(=O)c3cc4ccccc4[nH]3)cc2c1 CHEMBL7600 IC50 20.0 nM
COc1cc2c(N3CCN(/C(S)=N\Cc4ccc5c(c4)OCO5)CC3)ncnc2cc1OCCN1CCCCC1 CHEMBL184227 IC50 20.0 nM
COc1cc2c(N3CCN(/C(S)=N\Cc4ccc(Cl)nc4)CC3)ncnc2cc1OCCCN1CCCCC1 CHEMBL365271 IC50 20.0 nM
COc1cc2c(N3CCN(/C(S)=N\Cc4ccc(-c5ccccc5)nc4)CC3)ncnc2cc1OCCCN1CCCCC1 CHEMBL186618 IC50 20.0 nM
O=c1[nH]c2ccccc2c(O)c1-c1nc2ccccc2[nH]1 CHEMBL377345 IC50 20.0 nM
COc1cccc(COc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)c1 CHEMBL1940267 IC50 20.0 nM
COc1cc2ncnc(Nc3ccc(CC(=O)Nc4cnn(C(C)C)c4)cc3)c2cc1OC CHEMBL1940275 IC50 20.0 nM
COc1ccc2c(Oc3cnc(CC(=O)Nc4cn(C)nc4C)c(OC)c3)ccnc2c1 CHEMBL2023496 IC50 20.0 nM
COc1cc(-c2c[nH]c(=O)c(-c3cc(OC)c(OC)c(OC)c3)n2)ccc1O CHEMBL3358999 IC50 20.0 nM
Cc1ccc(NC(=O)c2ccc3c(c2)CCC3N2CCN(CCO)CC2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL3690077 IC50 20.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1N1CCc2nc(N)ncc2C1 CHEMBL3702661 IC50 20.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cc4ccccc4n3C(N)=O)cc2)c1 CHEMBL3896265 IC50 20.0 nM
CSc1ncc2c(n1)CCN(c1cc(C(=O)Nc3cccc(C(F)(F)F)c3)ccc1C)C2 CHEMBL3920210 IC50 20.0 nM
CC(C)c1cccc(NC(=O)c2cccc(N3CCc4c(cnc5ccnn45)C3)c2)c1 CHEMBL3978214 IC50 20.0 nM
Cc1cc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)c2c(N)onc2n1 CHEMBL4240969 IC50 20.0 nM
Cc1cc(-c2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)c2c(N)onc2n1 CHEMBL4247248 IC50 20.0 nM
COc1cccc(-c2cc(-c3c(O)c4ccccc4oc3=O)nc(N)c2C#N)c1 CHEMBL4868909 IC50 20.0 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3cccc(N(C)C)c3)nc12 CHEMBL3651236 IC50 20.8 nM
Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)sc4c3)c2)n(C)n1 CHEMBL2409790 IC50 21.0 nM
Cc1ccc(NC(=O)c2ccc3c(c2)CCC3N2CC[C@@H](N(C)C)C2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL3690081 IC50 21.0 nM
NC(=O)c1c(-c2ccc(NC(=O)Nc3ccccc3)cc2)nsc1NC(=O)NCCCN1CCOCC1 CHEMBL3696072 IC50 21.0 nM
CC(C)c1cccc(NC(=O)c2cccc(N3CCc4nc(N)ncc4C3)c2)c1 CHEMBL3702602 IC50 21.0 nM
O=C(Nc1cccc(N2CCc3c(cnc4ccnn34)C2)c1)c1cccc(C(F)(F)F)c1 CHEMBL3954328 IC50 21.0 nM
CCN(CC)CCCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430247 IC50 21.3 nM
COc1ccc(N(C)c2nc(C)nc3oc(C)cc23)cc1 CHEMBL3298000 IC50 21.9 nM
COc1cc2c(N3CCN(C(=O)Nc4ccc(C#N)cc4)CC3)ncnc2cc1OCCCN1CCC(C)CC1 CHEMBL445636 IC50 22.0 nM
CS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3ccc(Cl)cc3)c2)c1 CHEMBL3901672 IC50 22.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1)c1ccccc1 CHEMBL4165429 IC50 22.0 nM
Cn1cc(-c2cc3c(N4CCN(c5ncc([C@@](C)(N)c6ccc(F)cc6)cn5)CC4)ncnn3c2)cn1 CHEMBL4204794 GI50 22.0 nM
COC(=O)Nc1ccc(-c2c(OC3CCN(C)CC3)nc3c(-c4ccc(OC)c(OC)c4)cnn3c2N)cc1 CHEMBL4634073 IC50 22.0 nM
Cc1[nH]c2c(c1C(=O)NCCN(C)C)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430261 IC50 22.7 nM
COc1ccc(N(C)c2nc(C)nc3oc(C)cc23)cc1 CHEMBL3297898 IC50 22.8 nM
CN(C)CCCc1cc(Nc2ncc3c(n2)-c2ccc(Cl)cc2NC(=S)C3)ccc1F CHEMBL1945501 IC50 23.0 nM
NC(=O)n1c(-c2ccc(NC(=O)Nc3ccccc3)cc2)cc2ccccc21 CHEMBL3939918 IC50 23.0 nM
COc1ccc(N(c2nc(C)nc3oc(C)cc23)C(C)C)cc1 CHEMBL3297999 IC50 23.1 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3cccnc3)nc12 CHEMBL3651219 IC50 23.5 nM
CCN(CC)Cc1ccc(C)n1-c1ccc(N/C(=C2\C(=O)Nc3cc(C(=O)OC)ccc32)c2ccccc2)cc1 CHEMBL4634687 IC50 23.8 nM
Cc1ccc(NC(=O)c2ccc3c(c2)CCC3N2CCN(C)CC2)cc1Nc1nccc(-c2ccncc2)n1 CHEMBL3690083 IC50 24.0 nM
NC(=O)c1c(-c2ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)cc2)nsc1NC(=O)NCCCN1CCOCC1 CHEMBL3696075 IC50 24.0 nM
CC(C)c1ccc(NC(=O)c2cccc(N3CCc4nc(N)ncc4C3)c2)cc1 CHEMBL3702612 IC50 24.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc2c(c1)N(C(=O)Cn1cccn1)CC2)c1ccccc1 CHEMBL4161551 IC50 24.0 nM
Cc1ccccc1-c1cc2nnc(Nc3ccc(S(=O)(=O)NCCN4CCCC4)cc3)nc2cc1C CHEMBL231237 IC50 24.3 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cc(-c4ccc(OCCN5CCOCC5)cc4)[nH]n3)cc2)no1 CHEMBL5407834 IC50 24.4 nM
Cc1nc(N(C)c2ccc3c(c2)CCO3)c2cc(C)oc2n1 CHEMBL3403513 IC50 24.6 nM
Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1 CHEMBL101253 Kd 25.0 nM
Cc1nc(N(C)c2ccc3occc3c2)c2cc(C)oc2n1 CHEMBL3403514 IC50 25.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc2c(c1)N(C(=O)CN1CCOCC1)CC2)c1ccccc1 CHEMBL4168811 IC50 25.0 nM
Cn1cc(-c2cc(Oc3ccc(NC(=O)NC(=O)Cc4ccc(F)cc4)cc3F)ccn2)cn1 CHEMBL5190097 IC50 25.0 nM
Nc1c(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)ccc2nccnc12 CHEMBL2004438 pKi 25.12 nM
Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C1(c2ncnc3[nH]cnc23)CC1 CHEMBL4466555 IC50 25.3 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cncc4[nH]nc(N)c34)c3ccccc23)c1 CHEMBL3951451 IC50 25.4 nM
COCCOc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5ccc(C)cc5)cc4)CC3)c2cc1OCCOC CHEMBL340137 IC50 26.0 nM
CN1CCN(c2ccc(Nc3ncc4cc(C#N)c(=O)n(C5CCCC5)c4n3)cc2)CC1 CHEMBL3115681 IC50 26.0 nM
Cc1ccoc1C(=O)Nc1cccc(C#Cc2cncc(C(=O)N=S(=O)(CCCO)CCCO)c2)c1 CHEMBL3896486 IC50 26.0 nM
Nc1ncc2c(n1)CCN(c1cccc(C(=O)Nc3cccc(C(F)(F)F)c3)c1)C2 CHEMBL3702605 IC50 26.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(-n2cccc2CN(C)C)nc1)c1ccccc1 CHEMBL4647154 IC50 26.0 nM
Cc1ccc(F)cc1-c1cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc2cc1C CHEMBL3651212 IC50 26.1 nM
CN(C)CCCc1cncc(Nc2ncc3c(n2)-c2ccc(Cl)cc2NC(=S)C3)c1 CHEMBL1945803 IC50 27.0 nM
COc1ccc(Nc2ncc3c(n2)-c2ccc(Cl)cc2NC(=S)C3)cc1CCCN(C)C CHEMBL1945502 IC50 27.0 nM
O=C(Nc1cccc(C#Cc2ccc3nccn3n2)c1)c1ccccc1 CHEMBL3955638 IC50 27.0 nM
COC(=O)CCCC[S@@](C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3occc3C)c2)c1 CHEMBL4112857 IC50 27.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3cc(C)ccc3F)c2)c1 CHEMBL3960598 IC50 27.0 nM
O=C(Nc1cccc(C(F)(F)F)c1)c1cccc(N2CCc3c(cnc4ccnn34)C2)c1 CHEMBL3940300 IC50 27.0 nM
CN1CCN(CC(=O)N(C)c2ccc(N/C(=C3\C(=O)Nc4cc(OC(F)(F)F)ccc43)c3ccccc3)cc2)CC1 CHEMBL4169611 IC50 27.0 nM
Cc1nc(NC(=O)NC(=O)CC2CCCCC2)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5176270 IC50 27.0 nM
Cc1nc(NC(=O)NC(=O)C2CCCCC2)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5177368 IC50 27.0 nM
CCN(c1ccc(OC)cc1)c1nc(C)nc2oc(C)cc12 CHEMBL3297899 IC50 27.1 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(-n2cccc2CN2CCCC2)cc1)c1ccccc1 CHEMBL4091341 IC50 27.11 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 28.0 nM
Cc1cc(C=C2C(=O)Nc3ccc(F)cc32)c2ccccc(OCCN3CCC[C@H]3CO)c1-2 CHEMBL1258603 IC50 28.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 28.0 nM
Cc1ccc(F)c(NC(=O)Nc2cccc(C#Cc3cncc(C(=O)N=S(C)(C)=O)c3)c2)c1 CHEMBL3985264 IC50 28.0 nM
NC(=O)n1c(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)cc2ccccc21 CHEMBL3920784 IC50 28.0 nM
COC(=O)c1ccc2c(C(Nc3ccc(N(C)C(=O)CN4CCN(C)CC4)cc3)c3ccccc3)c(O)[nH]c2c1 CHEMBL5201102 IC50 28.0 nM
Cc1nc(Nc2cccc3[nH]ccc23)c2cc(C)oc2n1 CHEMBL3297896 IC50 28.3 nM
CCc1ccc(N(C)c2ncnc3occ(C)c23)cc1 CHEMBL4242522 IC50 28.9 nM
COc1cc2c(N3CCN(C(=O)Nc4ccc(C#N)cc4)CC3)ncnc2cc1OCCCN1CCCCC1C CHEMBL126699 IC50 29.0 nM
COc1cc2c(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCCN1CCCC(F)(F)C1 CHEMBL125431 IC50 29.0 nM
CCN(CC)CCN1Cc2[nH]c(/C=C3\C(=O)Nc4ccc(I)cc43)c(C)c2C1=O CHEMBL5176427 IC50 29.3 nM
COc1cccc2cc(N(C)c3nc(C)nc4ccccc34)ccc12 CHEMBL4746488 IC50 29.4 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(Cn2cccc2CN(C)C)cc1)c1ccccc1 CHEMBL4086939 IC50 29.79 nM
CCCN(c1ccc(OC)cc1)c1nc(C)nc2oc(C)cc12 CHEMBL3297900 IC50 29.9 nM
COc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cc1OC CHEMBL327300 IC50 30.0 nM
COc1cc2ncnc(N3CCN(C(=O)Nc4ccc(C(C)(C)C)cc4)CC3)c2cc1OC CHEMBL105280 IC50 30.0 nM
COc1cc2c(N3CCN(/C(S)=N\Cc4ccc(C(F)(F)F)nc4)CC3)ncnc2cc1OCCCN1CCCCC1 CHEMBL361517 IC50 30.0 nM
CNc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2ccccc12 CHEMBL521552 IC50 30.0 nM
Cc1ccc2[nH]c(-c3c(N)c4ccccc4[nH]c3=O)nc2c1 CHEMBL498205 IC50 30.0 nM
CN1CCN(c2ccc3[nH]c(-c4c(N)c5cc(F)c(N(C)C)cc5[nH]c4=O)nc3c2)CC1 CHEMBL498348 IC50 30.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 30.0 nM
Cc1ccc(C(=O)Nc2cccc(C(C)C)c2)cc1N1CCc2nc(N)ncc2C1 CHEMBL3702663 IC50 30.0 nM
O=C(Nc1cccc(C(F)(F)F)c1)c1cccc2cc(Oc3cc(CO)ncn3)ccc12 CHEMBL4080062 IC50 30.0 nM
Nc1nccc(Oc2ccc3c(C(=O)Nc4cccc(C(F)(F)F)c4)cccc3c2)n1 CHEMBL4104297 IC50 30.0 nM
COc1ccc2c(c1)CCCN2c1nc(C)nc2c(Cc3ccccc3)cn(C)c12 CHEMBL4104515 IC50 30.2 nM
Nc1ncc(NC(=O)c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2Cl)cc1Cl CHEMBL475817 IC50 31.0 nM
COC(=O)CCCC[S@](C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3occc3C)c2)c1 CHEMBL3906392 IC50 31.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(NC(=O)c3occc3C)c2)c1 CHEMBL3974963 IC50 31.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(-n2cccc2CN(C)C)c(C)c1)c1ccccc1 CHEMBL4642920 IC50 31.0 nM
CCN(CC)Cc1cccn1-c1ccc(N/C(=C2\C(=O)Nc3cc(C(=O)OC)ccc32)c2ccccc2)cc1 CHEMBL4070403 IC50 31.36 nM
CN(C)c1ccc2c(Oc3ccc(NC(=O)NCc4ccc(C(F)(F)F)nc4)cc3)ncnc2c1 CHEMBL4847875 IC50 31.5 nM
COc1cc(-c2csc3c(C=CC(=O)NCCN(C)C)cnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C CHEMBL1989267 pKi 31.62 nM
O=C(Nc1ccc(C#Cc2ccc3nccn3n2)cc1)Nc1cccc(C(F)(F)F)c1 CHEMBL3939257 IC50 32.0 nM
CCCc1ccc(NC(=O)c2cccc(N3CCc4nc(N)ncc4C3)c2)cc1 CHEMBL3702610 IC50 32.0 nM
Cc1cccc(NC(=O)Nc2cccc(N3CCc4c(cnc5ccnn45)C3)c2)c1 CHEMBL3982995 IC50 32.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(-n2c(C)ccc2CN(C)C)nc1)c1ccccc1 CHEMBL4638817 IC50 32.0 nM
Cc1ccoc1C(=O)Nc1ccc(-n2ccc(C)c(N3CCc4nc(N)ncc4C3)c2=O)cc1 CHEMBL3984713 IC50 33.0 nM
Cc1cccc(NC(=O)Nc2ccc(C#Cc3ccc4nc(N)cn4n3)cc2)c1 CHEMBL3961214 IC50 34.0 nM
Cc1ccoc1C(=O)Nc1cccc(C#Cc2cncc(C(=O)N=S3(=O)CCCC3)c2)c1 CHEMBL3986945 IC50 34.0 nM
CN1CCN(CC(=O)N(C)c2ccc(N/C(=C3\C(=O)Nc4cc(-c5cnco5)ccc43)c3ccccc3)cc2)CC1 CHEMBL4161897 IC50 34.0 nM
CCn1cc(CN(C)C)c2cc(N/C(=C3\C(=O)Nc4cc(C(=O)OC)ccc43)c3ccccc3)ccc21 CHEMBL4173078 IC50 34.3 nM
COc1cc2c(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCCN1CCCCC1C CHEMBL107599 IC50 35.0 nM
COc1cc2c(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCCS(=O)(=O)CC(C)C CHEMBL59735 IC50 36.0 nM
Cc1cccc(NC(=O)Nc2ccc(N3CCc4ccncc4C3)c(C)c2)c1 CHEMBL3644550 IC50 36.0 nM
FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1 CHEMBL3813873 IC50 36.0 nM
CCc1cccc(NC(=O)Nc2ccc(-c3[nH]c4ccccc4c3C(N)=O)cc2)c1 CHEMBL3975267 IC50 37.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(-n2c(C)ccc2CN2CCOCC2)cc1)c1ccccc1 CHEMBL4649259 IC50 37.0 nM
CNC(=O)c1cccc(-c2cnc3cc(-c4cnn(C)c4)c(OC)nn23)c1 CHEMBL5201556 IC50 38.0 nM
CCCN(c1ccc(OC)cc1)c1ncnc2occ(C)c12 CHEMBL4237916 IC50 38.9 nM
COc1cc2c(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCCN1CCC(C)CC1 CHEMBL330863 IC50 39.0 nM
CN1CCN(c2ccc3[nH]c(-c4c(N)c5cc(NC(=O)c6ccccc6)ccc5[nH]c4=O)nc3c2)CC1 CHEMBL495530 IC50 39.0 nM
CCn1c(C(=O)N2CCN(C)CC2)cc2cc(N/C(=C3\C(=O)Nc4cc(C(=O)OC)ccc43)c3ccccc3)ccc21 CHEMBL4161991 IC50 39.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(N)=O CHEMBL1289601 IC50 39.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)NC5CC5)CC4)c(Cl)c3)c2cc1C(N)=O CHEMBL5201128 IC50 39.0 nM
COc1cc2nc(Nc3ccc(S(=O)(=O)NCCN4CCCC4)cc3)nnc2cc1-c1ccccc1C CHEMBL3651227 IC50 39.3 nM
O=C1Nc2cc(-c3ccc(O)cc3)ccc2C1=Cc1ccc[nH]1 CHEMBL1980329 pKi 39.81 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1979690 pKi 39.81 nM
O=C(O)CCc1c(/C=C2\C(=O)Nc3cc(-c4ccccc4)ccc32)[nH]c2c1CCCC2 CHEMBL88771 IC50 40.0 nM
CCOc1cc2c(N3CCN(C(=O)Nc4ccc(Oc5ccccc5)cc4)CC3)ncnc2cc1OC CHEMBL100736 IC50 40.0 nM
COc1cc2c(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCCN1CCC(F)(F)CC1 CHEMBL124089 IC50 40.0 nM
COCCOc1ccc2c(N3CCN(C(=O)Nc4ccc(Oc5ccccc5)cc4)CC3)ncnc2c1 CHEMBL127886 IC50 40.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)NNc4ccccc4)cc32)c(C)c1CCC(=O)O CHEMBL480356 IC50 40.0 nM
COc1cc2ncnc(Oc3ccc(CC(=O)Nc4cnn(C)c4)cc3)c2cc1OC CHEMBL1940271 IC50 40.0 nM
CC(C)c1cccc(NC(=O)c2cccc(N3CCc4ccncc4C3)c2)c1 CHEMBL3644552 IC50 40.0 nM
Cc1cc(-c2ccc(NC(=O)Nc3cccc(Cl)c3)cc2)c2c(N)onc2n1 CHEMBL4237289 IC50 40.0 nM
Cc1[nH]c2c(c1C(=O)N1CCOCC1)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430251 IC50 40.1 nM
CCN1CCN(c2ccc(Nc3ncc(C)c(Nc4ccc5cn[nH]c5c4)n3)c(OC)c2)CC1 CHEMBL5190005 IC50 40.3 nM
COc1ccc(N(C)c2nc(C)nc3oc(C)cc23)c(OC)c1 CHEMBL3403509 IC50 40.4 nM
Cc1[nH]c2c(c1C(=O)N1CCC(N3CCCCC3)CC1)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430252 IC50 40.7 nM
Cc1cnc(Nc2ccc(N3CCS(=O)(=O)CC3)cc2)nc1Nc1ccc2cn[nH]c2c1 CHEMBL5187885 IC50 40.9 nM
CCN(CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1)CCOP(=O)(O)O CHEMBL415049 Kd 41.0 nM
CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1 CHEMBL215152 Kd 41.0 nM
COc1cc(O)c2c(c1)/C=C/C[C@@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O CHEMBL1668411 IC50 41.0 nM
CC(=O)N1CCN(C2CCc3cc(C(=O)Nc4ccc(C)c(Nc5nccc(-c6cccnc6)n5)c4)ccc32)CC1 CHEMBL3690078 IC50 41.0 nM
COc1ccc(-c2cnn3c(N)c(-c4nccs4)c(OC4CCN(C)CC4)nc23)cc1OC CHEMBL4636995 IC50 41.0 nM
Cc1cc(O)cc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1 CHEMBL3648035 IC50 41.1 nM
Cc1[nH]c2c(c1C(=O)NCCN1CCCC1)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430260 IC50 41.6 nM
Cc1c(NC(=O)CCN2CCCC2)c[nH]c1/C=C1\C(=O)Nc2ccc(F)cc21 CHEMBL4869059 IC50 41.8 nM
NC(=O)c1ccc(Nc2cc(-c3ccc(F)cc3)[nH]n2)cc1 CHEMBL511337 Kd 42.0 nM
O=C(O)CCc1c(/C=C2\C(=O)Nc3ccc(F)cc32)[nH]c2c1C(=O)CCC2 CHEMBL1214783 IC50 42.0 nM
COc1ccc(N(c2ncnc3occ(C)c23)C(C)C)cc1 CHEMBL4250273 IC50 42.6 nM
O=C(Nc1ccc(C#Cc2ccc3nccn3n2)cc1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL3985362 IC50 43.0 nM
COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(C#Cc2cccc(C(=O)Nc3cc(C)ccc3F)c2)c1 CHEMBL3943327 IC50 43.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc(C)c(Nc2ccc3cn[nH]c3c2)n1 CHEMBL5183593 IC50 44.1 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc2c(c1)cc(C(=O)N1CCN(C)CC1)n2C)c1ccccc1 CHEMBL4166696 IC50 44.2 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 Kd 45.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N2CCC(CN3CCN(C)CC3)C2=O)cc1)c1ccccc1 CHEMBL4166187 IC50 45.0 nM
CCn1c(=O)c(-c2cc(NC(=O)Nc3ccccc3)c(F)cc2Br)cc2cnc(NC)cc21 CHEMBL4216467 GI50 45.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(-n2c(C)ccc2CN(C)C)cc1)c1ccccc1 CHEMBL4640617 IC50 45.3 nM
Cc1cccc(NC(=O)Nc2ccc(-c3ccc(OCCCN4CCCC4)c4[nH]nc(N)c34)c3ccccc23)c1 CHEMBL3914717 IC50 45.4 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc2c(c1)nc(CN(C)C)n2C)c1ccccc1 CHEMBL4169257 IC50 45.5 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(-n2cccc2CN2CCCCC2)cc1)c1ccccc1 CHEMBL4059568 IC50 45.52 nM
CNC(=O)c1cc(Oc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2)ccn1 CHEMBL4227505 Kd 46.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3nsc(NC(=O)NCCCN4CCOCC4)c3C(N)=O)cc2)c1 CHEMBL3696073 IC50 47.0 nM
Cc1cnc(Nc2ccc(C(=O)N3CCN(C)CC3)cc2)nc1Nc1ccc2cn[nH]c2c1 CHEMBL5188763 IC50 47.7 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3snc(N)c3C(N)=O)cc2)c1 CHEMBL3696096 IC50 48.0 nM
C=CS(=O)(=O)NCc1ccc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc1 CHEMBL4245969 GI50 48.0 nM
Cc1cc2nc(Nc3ccc(S(=O)(=O)NCCN4CCCC4)cc3)nnc2cc1-c1c(C)cccc1C CHEMBL230816 IC50 48.1 nM
Cc1ncc(CCCN(C)C)cc1Nc1ncc2c(n1)-c1ccc(Cl)cc1NC(=S)C2 CHEMBL1945804 IC50 49.0 nM
Cc1ccc(CCCN(C)C)cc1Nc1ncc2c(n1)-c1ccc(Cl)cc1NC(=S)C2 CHEMBL1945171 IC50 49.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc2c(c1)c(CN(C)C)cn2C(C)C)c1ccccc1 CHEMBL4162400 IC50 49.2 nM
C=CCOc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5ccccc5)cc4)CC3)c2cc1OC CHEMBL342515 IC50 50.0 nM
COCCOc1cc2ncnc(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)c2cc1OCCOC CHEMBL125451 IC50 50.0 nM
COc1cc2c(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCCS(=O)(=O)CCC(C)C CHEMBL339403 IC50 50.0 nM
COc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5cccc6ccccc56)cc4)CC3)c2cc1OC CHEMBL103861 IC50 50.0 nM
COc1cc2c(N3CCN(/C(S)=N\Cc4cnc(C)cn4)CC3)ncnc2cc1OCCCN1CCCCC1 CHEMBL184753 IC50 50.0 nM
COc1cc2c(N3CCN(/C(S)=N\Cc4cccnc4)CC3)ncnc2cc1OCCCN1CCCCC1 CHEMBL184414 IC50 50.0 nM
COc1cc2c(N3CCN(/C(S)=N\Cc4cnc(C)cn4)CC3)ncnc2cc1OCCN1CCCCC1 CHEMBL187280 IC50 50.0 nM
COc1cc2c(N3CCN(/C(S)=N\Cc4ccc(Cl)nc4)CC3)ncnc2cc1OCCN1CCCCC1 CHEMBL186682 IC50 50.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccccc32)c(C)c1CCC(=O)O CHEMBL274654 IC50 50.0 nM
Cc1cc2c(F)c(Oc3ncnn4cc(OC[C@@H](C)O)c(C)c34)ccc2[nH]1 CHEMBL377300 Kd 50.0 nM
CCn1cc(NC(=O)Cc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)c(OC)c2)cn1 CHEMBL2023116 IC50 50.0 nM
COc1cc(Oc2ncnc3cc(OC)c(OC)cc23)ccc1CC(=O)Nc1cn(C)nc1C CHEMBL2023487 IC50 50.0 nM
Cc1nc(N(C)c2ccc3c(c2)OCO3)c2cc(C)oc2n1 CHEMBL3403512 IC50 50.1 nM
COc1cc2c(cc1F)C(c1ccccc1Cl)=Nc1c(n[nH]c1C)N2 CHEMBL1980391 pKi 50.12 nM
Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCCN4CCN(C)CC4)cc3)nnc2c1 CHEMBL3648037 IC50 50.3 nM
CCN(c1ccc(OC)cc1)c1ncnc2occ(C)c12 CHEMBL4241638 IC50 51.4 nM
CCc1cccc(NC(=O)c2cccc(N3CCc4nc(N)ncc4C3)c2)c1 CHEMBL3702609 IC50 52.0 nM
COc1cc2c(N3CCN(C(=O)Nc4ccc(C#N)cc4)CC3)ncnc2cc1OCCCN1CCCCC1 CHEMBL338597 IC50 53.0 nM
CC(C)(C)c1ccc(C(=O)NCc2ccc(-c3ncnc4[nH]ccc34)cc2)cc1 CHEMBL4755663 Kd 53.0 nM
Cc1nc(NC(=O)NC(=O)C2CCCC2)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5174778 IC50 53.0 nM
COc1cccc2c1Cc1c-2n[nH]c1Nc1ccccc1 CHEMBL371910 IC50 54.0 nM
COc1ccc2c(c1)CCCN2c1ncnc2ccccc12 CHEMBL3604205 IC50 54.0 nM
COc1ccc2[nH]c(C(=O)c3cc4ccc(Cl)cc4[nH]3)cc2c1 CHEMBL206915 IC50 55.0 nM
Nc1cn2nc(C#Cc3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)ccc2n1 CHEMBL3948032 IC50 55.0 nM
NC(=O)n1c(-c2ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)cc2)cc2ccccc21 CHEMBL3981808 IC50 55.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(-n2cccc2CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL4079087 IC50 55.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(C)c(Nc2ccc3cn[nH]c3c2)n1 CHEMBL5190076 IC50 55.6 nM
CCCCN(c1ccc(OC)cc1)c1nc(C)nc2oc(C)cc12 CHEMBL3297998 IC50 56.5 nM
COc1ccc(Nc2ncnc3occ(C)c23)cc1 CHEMBL4245874 IC50 57.3 nM
CNc1ccc(N(C)c2ncnc3occ(C)c23)cc1 CHEMBL4250210 IC50 57.8 nM
CN(c1ccnc(Nc2cc(N3CCOCC3)cc(N3CCOCC3)c2)n1)c1cccc2[nH]ncc12 CHEMBL1269858 IC50 58.0 nM
COc1ccc2c(c1)CCCN2c1nc(C)nc2oc(C)cc12 CHEMBL3403517 IC50 58.2 nM
Cc1cc(C(=O)Nc2cccc(C(C)C)c2)cc(N2CCc3nc(N)ncc3C2)c1 CHEMBL3702664 IC50 59.0 nM
CCC(=O)Nc1cc(Nc2ncc(C(=O)Nc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)c(NC)n2)ccc1C CHEMBL4093840 GI50 59.0 nM
CCOc1cc(N2CCN(C)CC2)ccc1Nc1ncc2cc(-c3cccc(NC(=O)c4cccc(C(F)(F)F)c4)c3)c(=O)n(C[C@H]3CCCO3)c2n1 CHEMBL5415503 IC50 59.04 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(Br)cc32)c(C)c1CCC(=O)O CHEMBL357803 IC50 60.0 nM
C#CCOc1cc2c(N3CCN(C(=O)Nc4ccc(Oc5ccccc5)cc4)CC3)ncnc2cc1OC CHEMBL448729 IC50 60.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccccc32)c(C)c1CCCN1CCN(C)CC1 CHEMBL430155 IC50 60.0 nM
COc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Cc5ccccc5)cc4)CC3)c2cc1OC CHEMBL103690 IC50 60.0 nM
COc1cc2c(N3CCN(/C(S)=N\c4ccncc4)CC3)ncnc2cc1OCCCN1CCCCC1 CHEMBL184180 IC50 60.0 nM
Cc1cccc(C)c1-c1cc(C)c2nc(Nc3nc(C(=O)NCCN4CCCC4)cs3)nnc2c1 CHEMBL3648061 IC50 60.0 nM
Cc1ccc(NC(=O)Nc2ccc(-c3nsc(N)c3C(N)=O)cc2)cc1 CHEMBL3696087 IC50 60.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc2[nH]cc(CN(C)C)c2c1)c1ccccc1 CHEMBL4164318 IC50 60.7 nM
Nc1ncc2c(n1)CCN(c1cccc(C(=O)Nc3ccc(F)c(C(F)(F)F)c3)c1)C2 CHEMBL3644560 IC50 61.0 nM
NC(=O)c1c(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)[nH]c2ccccc12 CHEMBL3913556 IC50 61.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc2c(c1)nc(CN1CCN(C)CC1)n2C)c1ccccc1 CHEMBL4177112 IC50 61.0 nM
Cc1ccc(NC(=O)c2ccc(CN(CCN(C)C)C(=O)C(C)(C)C)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL4251137 GI50 61.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2cccc(F)c21 CHEMBL2430256 IC50 62.1 nM
CSc1ccc(N(C)c2ncnc3occ(C)c23)cc1 CHEMBL4239716 IC50 62.2 nM
Cc1coc2ncnc(N(C)c3ccc(N(C)C)cc3)c12 CHEMBL4245415 IC50 63.0 nM
Cc1cc(=O)n2ccc(CN(C)C)c(O)c2n1 CHEMBL1988581 pKi 63.1 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 63.1 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(C=Cc3ccccc3)n2)n[nH]1 CHEMBL1983923 pKi 63.1 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(C4=Nc5cscc5NC(=O)C4)cc3)cc2C(F)(F)F)CC1 CHEMBL4228601 IC50 63.4 nM
COc1ccc(Nc2nc(C)nc3oc(C)cc23)cc1 CHEMBL3297897 IC50 63.5 nM
CC1(C)c2cc(C3CCN(CC4CCOCC4)CC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3735648 IC50 64.2 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc2c(c1)c(CN(C)C)cn2C)c1ccccc1 CHEMBL4172205 IC50 64.6 nM
Cc1[nH]c2c(c1C(=O)NCCCN1CCCC1)CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2430249 IC50 64.8 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL3039504 IC50 65.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(-n2cccc2CN2CCNCC2)cc1)c1ccccc1 CHEMBL4061361 IC50 65.24 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1NC(=O)c1cccc2c(N)nccc12 CHEMBL3967980 IC50 66.0 nM
CNC(=O)c1cccc(-c2cnc3cc(-c4cnn(C)c4)c(O[C@H]4CCOC4)nn23)c1 CHEMBL5200643 IC50 66.0 nM
Cc1nc(Nc2ccc(C(F)(F)F)cc2)c2cc(C)oc2n1 CHEMBL3297893 IC50 66.1 nM
COc1ccc(N(C)c2nc(C)nc3oc(C)cc23)cc1OC CHEMBL3403510 IC50 66.1 nM
Cc1ccc(NC(=O)Nc2ccc(C#Cc3ccc4nccn4n3)cc2)cc1 CHEMBL3980495 IC50 67.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(Cn2cccc2CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL4098962 IC50 67.85 nM
Cc1cc(C)c(/C=C2\C(=O)Nc3ccccc32)[nH]1 CHEMBL276711 IC50 68.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL1240703 Kd 68.0 nM
COc1cc2c(Oc3ccc(Nc4ccc(C(C)(C)C)cc4)cc3)ccnc2cc1OCCNCCO CHEMBL352308 IC50 69.0 nM
Cc1cccc(C)c1-c1cc(C)c2nc(Nc3cccc(OCCN4CCN(C)CC4)c3)nnc2c1 CHEMBL230615 IC50 69.1 nM
O=C(Nc1ccc(Oc2ccccc2)cc1)N1CCN(c2ncnc3cc4c(cc23)OCCO4)CC1 CHEMBL359007 IC50 70.0 nM
C#CCOc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5ccccc5)cc4)CC3)c2cc1OC CHEMBL148259 IC50 70.0 nM
COc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5ccccc5)cc4)CC3)c2cc1OS(C)(=O)=O CHEMBL344091 IC50 70.0 nM
CC(=O)Oc1ccc2[nH]c(C(=O)c3cc4ccccc4[nH]3)cc2c1 CHEMBL7572 IC50 70.0 nM
COc1cc2c(N3CCN(/C(S)=N\c4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCCN1CCCCC1 CHEMBL182515 IC50 70.0 nM
COc1cc2c(N3CCN(/C(S)=N\c4ccc(-c5ccccn5)cc4)CC3)ncnc2cc1OCCN1CCCCC1 CHEMBL186851 IC50 70.0 nM
O=c1[nH]c2ccccc2cc1-c1nc2ccccc2[nH]1 CHEMBL118440 IC50 70.0 nM
CN(C)c1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2ccccc12 CHEMBL495983 IC50 70.0 nM
COc1cc(-c2cnc3c(N4CCOCC4)snc3c2)cc(OC)c1OC CHEMBL3425865 Kd 70.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3nsc(N)c3C(N)=O)cc2)c1 CHEMBL3696088 IC50 70.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3snc(NCCCN4CCOCC4)c3C(N)=O)cc2)c1 CHEMBL3696097 IC50 70.0 nM
Cc1cccc(NC(=O)Nc2ccc(C#Cc3ccc4nccn4n3)cc2)c1 CHEMBL3972326 IC50 70.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(C(=O)OC)cc21 CHEMBL2430255 IC50 70.3 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1cnc(-n2cccc2CN(C)C)c(C)c1)c1ccccc1 CHEMBL4647153 IC50 71.0 nM
CN(C)CCCc1cc(Nc2ncc3c(n2)-c2ccc(Cl)cc2NC(=S)C3)ccc1C(F)(F)F CHEMBL1945801 IC50 72.0 nM
COc1ccc2c(c1)CCN2c1nc(C)nc2oc(C)cc12 CHEMBL3403515 IC50 73.2 nM
Cc1cc(F)ccc1-c1cc2nnc(Nc3ccc(S(=O)(=O)NCCN4CCCC4)cc3)nc2cc1C CHEMBL397691 IC50 73.7 nM
COc1cc2c(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCCN(C)C CHEMBL340234 IC50 76.0 nM
Cc1cccc(C)c1-c1cc(C)c2nc(Nc3cccc(OCCCN4CCN(C)CC4)c3)nnc2c1 CHEMBL3648036 IC50 76.3 nM
COc1ccc(N(C)c2nc(Cl)nc3ccccc23)cc1 CHEMBL444724 IC50 76.6 nM
COc1cc2c(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCCN1CCCC1 CHEMBL123667 IC50 77.0 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 78.0 nM
COCCOc1cc2c(N3CCN(C(=O)Nc4ccc(C#N)cc4)CC3)ncnc2cc1OCCN1CCCCC1 CHEMBL341239 IC50 79.0 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 79.43 nM
CCOc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5ccccc5)cc4)CC3)c2cc1OCC CHEMBL144687 IC50 80.0 nM
COCCOc1cc2ncnc(N3CCN(/C(S)=N\Cc4ccc5c(c4)OCO5)CC3)c2cc1OC CHEMBL147277 IC50 80.0 nM
COCCOc1cc2c(N3CCN(/C(S)=N\Cc4ccc5c(c4)OCO5)CC3)ncnc2cc1OC CHEMBL148382 IC50 80.0 nM
COc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5ccccc5)cc4)CC3)c2cc1OC CHEMBL102346 IC50 80.0 nM
COc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Nc5ccccc5)cc4)CC3)c2cc1OC CHEMBL321990 IC50 80.0 nM
COc1cc2c(N3CCN(/C(S)=N\Cc4ccc(C)o4)CC3)ncnc2cc1OCCCN1CCCCC1 CHEMBL184129 IC50 80.0 nM
COc1ccc2c(c1)CCCN2c1nc(Cl)nc2ccccc12 CHEMBL2420867 IC50 80.6 nM
Nc1nc(Nc2ccc(COc3cccc(F)c3)cc2)c2c(n1)[nH]c1ccc(O)cc12 CHEMBL5194946 Ki 81.0 nM
Cc1cccc(C)c1-c1ccc2nc(Nc3cccc(S(=O)(=O)N4CCN(C)CC4)c3)nnc2c1 CHEMBL3651298 IC50 81.3 nM
Cc1cccc(C)c1-c1cc(C)c2nc(Nc3cccc(S(=O)(=O)N4CCN(C)CC4)c3)nnc2c1 CHEMBL436516 IC50 81.3 nM
Cc1ccc(NC(=O)c2ccc(CNC(=O)c3cccnc3)c(C(F)(F)F)c2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL4238799 GI50 82.0 nM
Cc1nc(N(C)c2ccc(OC(C)C)cc2)c2cc(C)oc2n1 CHEMBL3403518 IC50 84.0 nM
O=C(CC(=O)Nc1ccc2c(c1)NC(=O)/C2=C\c1ccc[nH]1)Nc1ccc(F)cc1 CHEMBL3322563 IC50 86.9 nM
CCCS(=O)(=O)CCCOc1cc2ncnc(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)c2cc1OC CHEMBL124369 IC50 87.0 nM
COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 CHEMBL24828 Kd 88.0 nM
Cc1c2ccc(N(C)c3ccnc(Nc4ccc(C(=O)Nc5ccccc5N)cc4)n3)cc2nn1C CHEMBL4213341 IC50 88.0 nM
COc1cc(Nc2ncc3c(n2)CCN(C(=O)c2cccnc2)C3)cc(OC)c1OC CHEMBL3985924 IC50 89.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccccc21 CHEMBL2430263 IC50 89.9 nM
COc1cc2ncnc(N3CCN(/C(S)=N\Cc4ccc5c(c4)OCO5)CC3)c2cc1OC CHEMBL102301 IC50 90.0 nM
COc1cc2ncnc(N3CCN(/C(S)=N\Cc4ccccc4)CC3)c2cc1OC CHEMBL319894 IC50 90.0 nM
O=C(Nc1ccc(Oc2ccccc2)cc1)N1CCN(c2ncnc3cc4c(cc23)OCO4)CC1 CHEMBL144749 IC50 90.0 nM
CCOC(=O)c1cnc2cc(OC)c(OC)cc2c1N1CCN(C(=O)Nc2ccc(Oc3ccccc3)cc2)CC1 CHEMBL357673 IC50 90.0 nM
COc1cc2ncnc(N3CCN(C(=O)Nc4ccc(Oc5ccccc5)cc4)CC3)c2cc1OCC#N CHEMBL144077 IC50 90.0 nM
COCCOc1cc2c(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCN1CCCCC1 CHEMBL124487 IC50 90.0 nM
O=C(c1cc2ccccc2[nH]1)c1cc2cc(O)ccc2[nH]1 CHEMBL7735 IC50 90.0 nM
COc1cc2c(N3CCN(/C(S)=N\Cc4ccc(C)nc4)CC3)ncnc2cc1OCCCN1CCCCC1 CHEMBL184235 IC50 90.0 nM
COc1cc2c(N3CCN(/C(S)=N\Cc4ccc(C(F)(F)F)nc4)CC3)ncnc2cc1OCCN1CCCCC1 CHEMBL184244 IC50 90.0 nM
Cc1ccc(NC(=O)c2cccc(N3CCc4nc(N)ncc4C3)c2)cc1 CHEMBL3702606 IC50 90.0 nM
CCCC(=O)N(CCN(C)C)Cc1ccc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc1 CHEMBL4244760 GI50 90.0 nM
COc1ccc(C(=O)Nc2ccc(C(=O)N/N=C3\C(=O)Nc4ccc(OC)cc43)cc2)cc1 CHEMBL4469330 IC50 90.0 nM
Cc1nc2cc3nc(-c4cccs4)cnc3cc2n1C CHEMBL2218927 IC50 90.0 nM
COc1ccc2c(c1)CCCN2c1nc(C)nc2c(Cc3ccccc3)c[nH]c12 CHEMBL4069672 IC50 90.3 nM
Cc1cnc(Nc2ccc(N3CCC(F)(F)CC3)cc2)nc1Nc1ccc2cn[nH]c2c1 CHEMBL5206811 IC50 90.9 nM
CN(c1ccc(F)c(NC(=O)c2cccc(OC(C)(C)C#N)c2Cl)c1)c1ccc2nc(NC(=O)C3CC3)sc2n1 CHEMBL2204532 IC50 91.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc2c(c1)N(C(=O)CN1CC(C)OC(C)C1)CC2)c1ccccc1 CHEMBL4173370 IC50 91.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc2c(c1)c(CN1CCN(C)CC1)cn2C)c1ccccc1 CHEMBL4165850 IC50 91.7 nM
COc1cc2c(Oc3ccc(NC(=O)c4nn(-c5ccccc5C(F)(F)F)c(=O)cc4C)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL3290931 IC50 92.3 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc2[nH]c(CN3CCN(C)CC3)cc2c1)c1ccccc1 CHEMBL4173756 IC50 92.7 nM
CN(C)CCCc1ccc(Cl)c(Nc2ncc3c(n2)-c2ccc(Cl)cc2NC(=S)C3)c1 CHEMBL1945172 IC50 93.0 nM
O=C(Nc1ccc(C#Cc2ccc3nccn3n2)cc1)Nc1cc(C(F)(F)F)ccc1F CHEMBL3897714 IC50 93.0 nM
COc1ccc(-c2ccc(NC(=O)Nc3cc(C)ccc3F)cc2)c2c(N)noc12 CHEMBL270084 IC50 96.0 nM
Cn1ccc2ncnc(Oc3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)c(F)c3)c21 CHEMBL1254007 IC50 96.0 nM
COc1cc2c(N3CCN(C(=O)Nc4ccc(C#N)cc4)CC3)ncnc2cc1OCCN1CCCCC1 CHEMBL340235 IC50 97.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(C(F)(F)F)c4)cc3)c2cc1OC CHEMBL4577779 IC50 97.0 nM
C=CC(=O)Nc1cc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc(C(F)(F)F)c1 CHEMBL4243753 GI50 98.0 nM