CC(C)(O)CCCOc1cc(-c2cnn(C(C)(C)C(N)=O)c2)c2c(c1)[C@@](O)(C(F)(F)F)c1ccccc1-2 CHEMBL3673097 IC50 4.2 nM
Cc1nc2[nH]c3c(C4CC4)cccc3c2cc1-c1nnc(C(NC(=O)CCc2ccccc2)C(C)C)o1 CHEMBL5079107 IC50 4.2 nM
Cc1nc(N2C[C@@](Cc3ccccc3)(C(N)=O)C[C@H]2CO)c2c(n1)[nH]c1c(C3CC3)cccc12 CHEMBL5079949 IC50 4.5 nM
CC(C)(O)CCOc1cc(-c2cnn(C(C)(C)C(N)=O)c2)c2c(c1)[C@@](O)(C(F)(F)F)c1ccccc1-2 CHEMBL3673096 IC50 4.6 nM
NC(=O)Cn1cc(-c2cc(OCCC34CC5CC(CC(O)(C5)C3)C4)cc3c2-c2ccccc2[C@]3(O)C(F)(F)F)cn1 CHEMBL3673092 IC50 5.1 nM
CC(C)(C(N)=O)n1cc(-c2cc(F)cc3c2-c2ccccc2[C@]3(O)C(F)(F)F)cn1 CHEMBL3673095 IC50 5.1 nM
Cc1nc(N2C[C@@H](c3ccc(C(=O)O)[nH]3)C[C@H]2CO)c2c(n1)[nH]c1c(C3CC3)cccc12 CHEMBL5087040 IC50 5.1 nM
Cc1nc(N2C[C@@H](c3ccc(C(N)=O)[nH]3)C[C@H]2CO)c2c(n1)[nH]c1c(C3CC3)cccc12 CHEMBL5072731 IC50 5.5 nM
Cc1nc2[nH]c3c(C4CC4)cccc3c2cc1-c1nnc(C(CC(=O)NCc2ccccc2)C(C)C)o1 CHEMBL5087238 IC50 6.0 nM
CC(C)(O)COc1cc(-c2cnn(CCO)c2)c2c(c1)[C@@](O)(C(F)(F)F)c1ccccc1-2 CHEMBL3673094 IC50 6.7 nM
Cn1cc(-c2cc(OCC(C)(C)O)cc3c2-c2ccccc2[C@]3(O)C(F)(F)F)cn1 CHEMBL3673093 IC50 7.4 nM
C[C@@H]1CN(C(=O)[C@](C)(O)C(F)(F)F)[C@@H](C)CN1C(=O)c1ccc(C#N)cc1 CHEMBL4579004 IC50 7.8 nM
CN(C)C(=O)c1ccc(N(Cc2cc(Br)cs2)C(=O)c2ccc(O)cc2O)cc1 CHEMBL4591977 IC50 8.0 nM
CC[C@@H]1C[C@H](c2ccc(C(=O)O)[nH]2)CN1c1nc(C)nc2[nH]c3c(C4CC4)cccc3c12 CHEMBL5089800 IC50 9.2 nM
CN(C)C(=O)c1ccc(N(Cc2ccc(Br)o2)C(=O)c2ccc(O)cc2O)cc1 CHEMBL4575355 IC50 10.0 nM
OCCCCOc1cc(-c2cnn(CCO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681809 IC50 14.0 nM
Cc1nc(N2C[C@](CO)(Cc3ccccc3)C[C@H]2CO)c2c(n1)[nH]c1c(C3CC3)cccc12 CHEMBL5092915 IC50 14.6 nM
CNC(=O)Cn1cc(-c2cc(C)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681707 IC50 15.0 nM
NC(=O)Cn1cc(-c2cc(OCCC34CC5CC(CC(O)(C5)C3)C4)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681729 IC50 15.0 nM
OCCn1cc(-c2cc(OCCC34CC5CC(CC(O)(C5)C3)C4)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681730 IC50 15.0 nM
Cc1cc(-c2cnn(C3(CO)CCCC3)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681734 IC50 15.0 nM
CC(C)=Cc1cc(-c2cnn(C(CO)CO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681843 IC50 15.0 nM
NC(=O)c1cc(-c2cnn(CC3CCCCC3)c2)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3681841 IC50 15.0 nM
Cc1cc(-c2cnn(CC(N)=O)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681702 IC50 16.0 nM
CNC(=O)Cn1cc(-c2cc(F)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681710 IC50 16.0 nM
Cn1cc(-c2cc(OCCC34CC5CC(CC(O)(C5)C3)C4)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681728 IC50 16.0 nM
OCC1(n2cc(-c3cc(F)cc4c3-c3ccccc3C4(O)C(F)(F)F)cn2)CCCC1 CHEMBL3681736 IC50 16.0 nM
CC(C)(C)Cn1cc(-c2cc(C(N)=O)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681829 IC50 16.0 nM
Cn1cc(-c2cc(Cl)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3676634 IC50 17.0 nM
Cc1cc(-c2cnn(CCO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681688 IC50 17.0 nM
OCC1(n2cc(-c3cc(F)cc4c3-c3ccccc3C4(O)C(F)(F)F)cn2)CCCCC1 CHEMBL3681733 IC50 17.0 nM
Cn1cc(-c2cc(OCCCCC(=O)O)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681740 IC50 17.0 nM
CC(C)(C)Cn1cc(-c2cc(CO)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681832 IC50 17.0 nM
OCc1cc(-c2cnn(CC3CCCCC3)c2)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3681845 IC50 17.0 nM
CC(C)(C)CCc1cc(-c2cnn(C(CO)CO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681844 IC50 17.0 nM
Cc1nc2[nH]c3c(C4CC4)cccc3c2cc1-c1nnc([C@@H](CC(=O)N[C@H](C)c2ccccc2)C(C)C)o1 CHEMBL5090085 IC50 17.1 nM
Cn1cc(-c2cc(OCC(N)=O)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681668 IC50 18.0 nM
NC(=O)COc1cc(-c2cnn(CCO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681676 IC50 18.0 nM
CC(C)n1cc(-c2cc(OCCCC(=O)O)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681741 IC50 18.0 nM
OC[C@@H](O)Cn1cc(-c2cc(F)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681753 IC50 18.0 nM
Cn1cc(-c2cc(OCCCc3nnn[nH]3)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681761 IC50 18.0 nM
Cc1cc(-c2cnn(CC(CO)CO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681842 IC50 18.0 nM
CN(C)C(=O)c1ccc(N(Cc2ccc(Br)s2)C(=O)c2ccc(O)cc2O)cc1 CHEMBL4551410 IC50 18.0 nM
CN(C)C(=O)CCCOc1cc(-c2cncnc2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676775 IC50 19.0 nM
Cn1cc(-c2cc(OCC(=O)N3CC(CO)C3)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681641 IC50 19.0 nM
Cn1cc(-c2cc(OCCCC(=O)O)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681651 IC50 19.0 nM
Cn1cc(-c2cc(-c3cnn(C)c3)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681767 IC50 19.0 nM
CCOc1cc(-c2cnn(CCC(=O)O)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681769 IC50 19.0 nM
Cc1cc(-c2cnn(C(CO)CO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681791 IC50 19.0 nM
Cc1cc(-c2cnn(C(CO)(CO)CO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3686492 IC50 19.0 nM
CC(C)(C)C(=O)N1CCN(c2cc(-c3cccnc3)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)CC1 CHEMBL3676633 IC50 20.0 nM
CN(C)C(=O)CCCOc1cc(-c2cnn(C)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676773 IC50 20.0 nM
Cn1cc(-c2cc(OCC(=O)N3CC(O)C3)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681674 IC50 20.0 nM
O=C1CCCN1CCOc1cc(-c2cn[nH]c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681687 IC50 20.0 nM
OCCn1cc(-c2cc(F)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681700 IC50 20.0 nM
CCn1cc(-c2cc(OCCCC(=O)O)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681742 IC50 20.0 nM
CCn1cc(-c2cc(C(N)=O)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681722 IC50 20.0 nM
O=C(c1cc(-c2cnn(CCO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CCCC1 CHEMBL3681675 IC50 20.0 nM
OCC(CO)(CO)n1cc(-c2cc(F)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681854 IC50 20.0 nM
CC(=O)N(C)CCOc1cc(-c2cnn(C)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676769 IC50 21.0 nM
CN(CCOc1cc(-c2cnn(C)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)C(=O)CO CHEMBL3676771 IC50 21.0 nM
OC[C@H](O)Cn1cc(-c2cc(F)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681754 IC50 21.0 nM
OCCn1cc(-c2cc(-c3cnn(CCO)c3)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681768 IC50 21.0 nM
CCOc1cc(-c2cnn(CCCC(=O)O)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681770 IC50 21.0 nM
CCn1cc(-c2cc(C(C)=O)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681775 IC50 21.0 nM
Cn1cc(-c2cc(OCCN3CCCC3=O)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3676758 IC50 22.0 nM
CN(CCOc1cc(-c2cnn(C)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)C(=O)C(C)(C)CO CHEMBL3639805 IC50 22.0 nM
OC1(Cn2cc(-c3cc(F)cc4c3-c3ccccc3C4(O)C(F)(F)F)cn2)CCCCC1 CHEMBL3681732 IC50 22.0 nM
OCC(CO)n1cc(-c2cc(F)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681783 IC50 22.0 nM
CC(CO)(CO)n1cc(-c2cc(F)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681847 IC50 22.0 nM
NC(=O)C[C@H](N)C(=O)N1CCC(Nc2ccc3c(c2)CN(S(=O)(=O)c2ccc(O)cc2O)C3)CC1 CHEMBL4103350 Kd 22.0 nM
CC(=O)N(C)CCOc1cc(-c2cncnc2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676768 IC50 23.0 nM
CN(CCOc1cc(-c2cncnc2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)C(=O)CO CHEMBL3676770 IC50 23.0 nM
O=C(COc1cc(-c2cnn(CCO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CCC1 CHEMBL3681692 IC50 23.0 nM
CC(CCOc1cc(-c2cnn(C)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)C(=O)O CHEMBL3681765 IC50 23.0 nM
CC(C)Cc1cc(-c2cnn(C(CO)CO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681830 IC50 23.0 nM
Cn1cc(-c2cc(OCCCCO)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3676772 IC50 24.0 nM
O=C1CCCN1CCOc1cc(-c2cnn(CCO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681681 IC50 24.0 nM
Cc1cc(C(=O)N2CCC2)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3671676 IC50 25.0 nM
OCCCCCOc1cc(-c2cncnc2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676752 IC50 25.0 nM
OCCCCOc1cc(-c2cncnc2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676774 IC50 25.0 nM
COc1cc(-c2cnn(CCCC(=O)O)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681777 IC50 25.0 nM
C/C=C/c1cc(-c2cnn(C(CO)CO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681833 IC50 25.0 nM
CN(C)C(=O)CCOc1cc(-c2cnn(C)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681656 IC50 26.0 nM
CN(CCOc1cc(-c2cnn(C)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)C(=O)C(C)(C)C CHEMBL3681672 IC50 26.0 nM
Cc1cc(-c2cnn(CCC(=O)O)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681726 IC50 26.0 nM
CC(=O)c1cc(-c2cnn(CCO)c2)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3681773 IC50 26.0 nM
Cc1cc(-c2cnn(CCCC(=O)O)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681727 IC50 27.0 nM
O=C(O)C1(n2cc(-c3cc(F)cc4c3-c3ccccc3C4(O)C(F)(F)F)cn2)CCCC1 CHEMBL3681737 IC50 27.0 nM
Cn1cc(-c2cc(OCCCO)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681654 IC50 28.0 nM
Cc1cc(-c2cnn(CCCCC(=O)O)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681792 IC50 28.0 nM
COc1cc(-c2cnn(CCC(=O)O)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681776 IC50 29.0 nM
CN(C)C(=O)COc1cc(-c2cnn(C)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681658 IC50 30.0 nM
OCCn1cc(-c2cc(Cl)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681661 IC50 30.0 nM
O=C(c1cc(-c2cnn(CCO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CCC1 CHEMBL3681662 IC50 30.0 nM
NC(=O)Cn1cc(-c2cc(Cl)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681701 IC50 30.0 nM
Cc1cc(-c2cnn(C(C)(C)CC(=O)O)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681764 IC50 30.0 nM
CC(C)(O)Cn1cc(-c2cc(F)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681848 IC50 30.0 nM
Cc1cc(-c2cnn(CCCc3nn[nH]n3)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681852 IC50 30.0 nM
CC(CO)(CO)n1cc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681853 IC50 30.0 nM
Cn1cc(-c2cc(OCCCCCO)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3676753 IC50 31.0 nM
O=C(COc1cc(-c2cnn(CCO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CC(O)C1 CHEMBL3681693 IC50 31.0 nM
CC(=O)N(C)C[C@H](O)COc1cc(-c2cnn(C)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681696 IC50 31.0 nM
OCC(CO)(CO)n1cc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3686491 IC50 31.0 nM
Cn1cc(-c2cc(C(=O)N3CC3)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3676760 IC50 32.0 nM
Cn1cc(-c2cc(OCC(=O)N3CCC(CO)CC3)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681642 IC50 32.0 nM
CN(CCOc1cc(-c2cnn(C)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)C(=O)C(C)(C)O CHEMBL3681697 IC50 32.0 nM
CNC(=O)Cn1cc(-c2cc(Cl)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681708 IC50 32.0 nM
CC(=O)c1cc(OCCN2CCCC2=O)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3681786 IC50 33.0 nM
COc1cc(-c2cnn(CC(C)(C)C(=O)O)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681804 IC50 33.0 nM
Cn1cc(-c2cc(OCC(CO)CO)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681807 IC50 33.0 nM
Cn1cc(-c2cc(OCC(=O)O)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3676705 IC50 34.0 nM
O=C(O)CCCn1cc(-c2cc(F)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681725 IC50 35.0 nM
O=C(O)CCCOc1cc(-c2cncnc2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681705 IC50 35.0 nM
Cc1cnc(Cl)nc1-c1ccc(N(Cc2ccccc2)C(=O)c2ccc(O)cc2O)cc1 CHEMBL3732469 IC50 35.0 nM
Cc1cc(C(=O)N2CC(C(=O)N(C)C)C2)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3671735 IC50 36.0 nM
Cn1cc(-c2cc(OCC(=O)N3CCC3)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681643 IC50 36.0 nM
NC(=O)CCn1cc(-c2cc(Cl)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681715 IC50 36.0 nM
O=C(O)CCn1cc(-c2cc(F)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681731 IC50 36.0 nM
Cc1cc(-c2cnn(CC(C)(C)C(=O)O)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681763 IC50 36.0 nM
CCCc1cc(-c2cnn(C(CO)CO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681834 IC50 36.0 nM
COc1cc(-c2cnn(C(C)(C)CC(=O)O)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681800 IC50 37.0 nM
CC(C)Cn1cc(-c2cc(C(N)=O)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681828 IC50 37.0 nM
CC(C)Cn1cc(-c2cc(CO)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681831 IC50 37.0 nM
CCc1cc(-c2cnn(C(CO)CO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681835 IC50 37.0 nM
CC(=O)NCCOc1cc(-c2cnn(C)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681637 IC50 39.0 nM
COc1cc(-c2cnn(CCO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681659 IC50 39.0 nM
NC(=O)Cn1cc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681689 IC50 39.0 nM
CC(=O)N(C)C[C@@H](O)COc1cc(-c2cnn(C)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681695 IC50 39.0 nM
Cn1cc(-c2cc(C(=O)N3CCC3)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3676702 IC50 40.0 nM
CNC(=O)COc1cc(-c2cnn(C)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681644 IC50 40.0 nM
O=C(O)CCCOc1cc(-c2cnn(CCO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681679 IC50 40.0 nM
CC(=O)c1cc(-c2cnn(C)c2)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3681784 IC50 41.0 nM
CC(C)(CC(=O)O)n1cc(-c2cc(F)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681796 IC50 41.0 nM
Cn1cc(-c2cc(OCCNC(=O)CCC(=O)C(F)(F)F)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681665 IC50 42.0 nM
CNC(=O)Cn1cc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681690 IC50 44.0 nM
Cn1cc(-c2cc(N3CCOCC3)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681757 IC50 44.0 nM
Cn1cc(-c2cc(OCCO)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681657 IC50 45.0 nM
NC(=O)COc1cc(-c2cn[nH]c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681699 IC50 45.0 nM
CC(C)(Cn1cc(-c2cc(F)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1)C(=O)O CHEMBL3681793 IC50 45.0 nM
CCn1cc(-c2cc(CO)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681803 IC50 45.0 nM
O=C(O)c1ccc(-c2cc(-c3cccnc3)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cc1 CHEMBL3676689 IC50 47.0 nM
NC(=O)COc1cc(-c2cncnc2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676710 IC50 47.0 nM
COc1cc(-c2cnn(C)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681664 IC50 47.0 nM
O=C(O)CCCOc1cc(-c2cn[nH]c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681694 IC50 47.0 nM
NC(=O)c1cc(OCCN2CCCOC2=O)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3681798 IC50 47.0 nM
NC(=O)c1cc(OCCN2CCCC2=O)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3681698 IC50 48.0 nM
NC(=O)Cn1cc(-c2cc(OCCC34CC5CC(CC(C5)C3)C4)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681703 IC50 48.0 nM
CC(C)(C)n1cc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681717 IC50 48.0 nM
CC(=O)c1cc(-c2cnn(CCC(=O)O)c2)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3681782 IC50 48.0 nM
O=C(c1cc(Cl)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CCC1 CHEMBL3671679 IC50 49.0 nM
CC(=O)c1cc(C(=O)N2CCC2)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3671706 IC50 49.0 nM
Cn1cc(-c2cc(C(=O)N3CC(O)C3)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3676720 IC50 49.0 nM
Cn1cc(-c2cc(C(=O)N3CC(CO)C3)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3676721 IC50 49.0 nM
CC(C)n1cc(-c2cc(C(N)=O)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681721 IC50 49.0 nM
Cn1cc(-c2cc(C(=O)N3CC(OCCO)C3)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3676722 IC50 50.0 nM
O=C(O)CCCOc1cc(-c2cccnc2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681749 IC50 50.0 nM
Cn1cc(-c2cc(OCC(O)CO)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681759 IC50 50.0 nM
O=C(c1cc(Br)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CCC1 CHEMBL3671698 IC50 51.0 nM
OCCn1cc(-c2cc(OCCC34CC5CC(CC(C5)C3)C4)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681704 IC50 51.0 nM
CC(C)(O)C(C)(C)n1cc(-c2cc(F)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681851 IC50 51.0 nM
CN(C)C(=O)CCn1cc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681685 IC50 52.0 nM
Cc1cc(-c2cnn(C(C)(C)C(=O)O)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681762 IC50 52.0 nM
OC1(C(F)(F)F)c2ccccc2-c2c(Cl)cc(-c3ccncc3)cc21 CHEMBL3671767 IC50 53.0 nM
COC(=O)c1cc(-c2cnn(C)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676690 IC50 53.0 nM
Cn1cc(-c2cc(C(=O)N3CCCC3)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3676703 IC50 53.0 nM
O=C(c1cc(CO)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CCC1 CHEMBL3681744 IC50 53.0 nM
Cc1cc(C(=O)N2CC(OCCO)C2)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3671734 IC50 54.0 nM
Cn1cc(-c2cc(C(N)=O)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681713 IC50 54.0 nM
NC(=O)c1cc(-c2cnn(CCO)c2)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3681724 IC50 54.0 nM
OC1(C(F)(F)F)c2ccccc2-c2c(-c3cnn(Cc4ccccc4)c3)cccc21 CHEMBL3681667 IC50 55.0 nM
NC(=O)CCn1cc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681683 IC50 55.0 nM
CC(C)c1cc(-c2cnn(C(CO)CO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681836 IC50 55.0 nM
CC(C)(C)C(=O)N1CCN(c2cc(Cl)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)CC1 CHEMBL3676619 IC50 56.0 nM
CCNC(=O)Cn1cc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681706 IC50 56.0 nM
Cc1nc2[nH]c3c(C4CC4)cccc3c2cc1-c1nnc(CC(C)C)o1 CHEMBL5080906 IC50 56.0 nM
O=C(O)CCn1cc(-c2cc(Cl)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681712 IC50 57.0 nM
O=C(O)c1ccc(-c2cc(Cl)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cc1 CHEMBL3676582 IC50 58.0 nM
Cn1cc(-c2cc(C(=O)N3CCC(CO)C3)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3676740 IC50 58.0 nM
CC(C)NC(=O)Cn1cc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681709 IC50 58.0 nM
Cn1cc(-c2cc(OC(CO)CO)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681813 IC50 58.0 nM
Cn1cc(-c2cnc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681750 IC50 59.0 nM
CC(C)(O)Cn1cc(-c2cc(CO)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681840 IC50 59.0 nM
O=C(COc1cc(Br)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CCC1 CHEMBL3681639 IC50 60.0 nM
CC(C)n1cc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681666 IC50 61.0 nM
OC1(C(F)(F)F)c2ccccc2-c2c(-c3cnn(C45CC6CC(CC(C6)C4)C5)c3)cccc21 CHEMBL3681716 IC50 61.0 nM
OC12CC3CC(C1)CC(Cn1cc(-c4cccc5c4-c4ccccc4C5(O)C(F)(F)F)cn1)(C3)C2 CHEMBL3681735 IC50 62.0 nM
CC(C)Cc1cc(-c2cnn(CCO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681814 IC50 62.0 nM
OCCCCCOc1cc(Cl)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676734 IC50 63.0 nM
CC(=O)N(C)CCOc1cc(Cl)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676735 IC50 63.0 nM
OCCn1cc(-c2cnc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681751 IC50 63.0 nM
CC(C)(C)n1cc(-c2cc(C(N)=O)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681822 IC50 63.0 nM
O=C1CCCN1CCOc1cnc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676776 IC50 64.0 nM
Cn1cc(-c2cc(OCCC(=O)O)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681655 IC50 64.0 nM
CNC(=O)CCn1cc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681684 IC50 64.0 nM
O=C1CCCN1CCOc1cc(CO)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681771 IC50 64.0 nM
CN(C)C(=O)c1ccc(N(Cc2ncc(Br)s2)C(=O)c2ccc(O)cc2O)cc1 CHEMBL4461160 IC50 64.0 nM
CN(CCOc1cc(Cl)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)S(C)(=O)=O CHEMBL3676754 IC50 65.0 nM
OCCCn1cc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681638 IC50 65.0 nM
OCCn1cc(-c2cc(CO)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681805 IC50 65.0 nM
CC(C)n1cc(-c2cc(CO)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681806 IC50 65.0 nM
NC(=O)C[C@H](N)C(=O)N1CC(Nc2ccc3c(c2)CN(S(=O)(=O)c2ccc(O)cc2O)C3)C1 CHEMBL4080017 IC50 65.0 nM
Cc1cnc(Cl)nc1-c1ccc(N(Cc2ccc(CNC(=O)C(F)F)cc2)C(=O)c2ccc(O)cc2O)cc1 CHEMBL3727577 IC50 65.0 nM
NC(=O)c1cc(C(=O)N2CCC2)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3671756 IC50 66.0 nM
CN(C)C(=O)C1CN(C(=O)c2cc(Cl)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)C1 CHEMBL3676676 IC50 66.0 nM
OCCn1cc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3676757 IC50 66.0 nM
CN(CCOc1cc(Cl)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)C(=O)CO CHEMBL3676755 IC50 67.0 nM
NC(=O)C[C@H](N)C(=O)NCCCNc1ccc2c(c1)CN(S(=O)(=O)c1ccc(O)cc1O)C2 CHEMBL4078432 IC50 67.0 nM
N[C@@H](CO)C(=O)N1CCC(Nc2ccc3c(c2)CN(S(=O)(=O)c2ccc(O)cc2O)C3)CC1 CHEMBL4104843 IC50 68.0 nM
Cc1cc(-c2cnn(CC(=O)O)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681738 IC50 69.0 nM
CN(C)C(=O)c1cc(-c2cnn(C)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676701 IC50 71.0 nM
NC(=O)c1cc(-c2cncnc2)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3681839 IC50 71.0 nM
NC(=O)CC[C@H](N)C(=O)N1CCC(Nc2ccc3c(c2)CN(S(=O)(=O)c2ccc(O)cc2O)C3)CC1 CHEMBL4085424 IC50 72.0 nM
NC(=O)c1cc(CCCN2CCCC2=O)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3681837 IC50 73.0 nM
Cc1nc(N2C[C@H](Cc3ccccc3)C[C@H]2CO)c2c(n1)[nH]c1c(C3CC3)cccc12 CHEMBL5094437 IC50 73.0 nM
OC1(C(F)(F)F)c2ccccc2-c2c(-c3cccnc3)cc(Cl)cc21 CHEMBL3676591 IC50 75.0 nM
O=C(O)CCCOc1cc(-c2cnco2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681799 IC50 76.0 nM
N#Cc1cc(C(=O)N2CCC2)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3671723 IC50 77.0 nM
Cn1cc(-c2cc(CO)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681745 IC50 77.0 nM
Cc1cc(-c2cnn(CCO)c2)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3681772 IC50 77.0 nM
O=C(c1cc(Cl)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CC(OCCO)C1 CHEMBL3676675 IC50 78.0 nM
C#Cc1cc(-c2cnn(C)c2)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3681766 IC50 78.0 nM
CC(C)(C)OC(=O)c1ccc(-c2cc(-c3cccnc3)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cc1 CHEMBL3676688 IC50 79.0 nM
CC(=O)NCCn1cc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681720 IC50 79.0 nM
OCC(CO)c1ncc(-c2cc(F)cc3c2-c2ccccc2C3(O)C(F)(F)F)o1 CHEMBL3681849 IC50 79.0 nM
OC1(C(F)(F)F)c2ccccc2-c2c(-c3cncnc3)cc(Cl)cc21 CHEMBL3676682 IC50 80.0 nM
CN(C)C(=O)c1ccc(S(=O)(=O)c2ccc(NC(=O)[C@@](C)(O)C(F)(F)F)c(Cl)c2)cc1 CHEMBL1231132 EC50 80.0 nM
O=C(c1cc(-c2cncnc2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CCC1 CHEMBL3676716 IC50 81.0 nM
Cn1cc(-c2cc(N3CCC(C(=O)O)CC3)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681746 IC50 81.0 nM
O=C(O)CCn1cc(-c2cnc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681756 IC50 83.0 nM
COC(=O)c1cc(Cl)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3681802 IC50 84.0 nM
Cn1cc(-c2cc(C(=O)N3CCC(O)C3)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3676723 IC50 85.0 nM
O=C(c1cc(-c2cccnc2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CCC1 CHEMBL3676590 IC50 86.0 nM
CC(C)(C)Cn1cc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681718 IC50 87.0 nM
Cc1nc2[nH]c3c(C4CC4)cccc3c2cc1-c1nnc(C(C)C(C)C)o1 CHEMBL5092147 IC50 87.0 nM
CCn1cc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3676694 IC50 88.0 nM
CC(C)Cn1cc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3676733 IC50 89.0 nM
COC(=O)c1cc(Br)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681673 IC50 90.0 nM
C[C@H](O)[C@H](N)C(=O)N1CCC(Nc2ccc3c(c2)CN(S(=O)(=O)c2ccc(O)cc2O)C3)CC1 CHEMBL4080613 IC50 91.0 nM
CCCc1nnc(-c2cc3c(nc2C)[nH]c2c(C4CC4)cccc23)o1 CHEMBL5085080 IC50 91.0 nM
CN(C)C(=O)c1ccc(N(Cc2ccc(C#N)s2)C(=O)c2ccc(O)cc2O)cc1 CHEMBL4513465 IC50 95.0 nM
CN(C)C(=O)c1ccc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cc1Cl CHEMBL3676589 IC50 98.0 nM
CN(C)C(=O)c1ccc(N(Cc2ccc(I)o2)C(=O)c2ccc(O)cc2O)cc1 CHEMBL4519504 IC50 98.0 nM
COC(=O)c1cc(C(=O)OC)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3671635 IC50 100.0 nM
CC[Si](CC)(CC)CCc1cc(C(N)=O)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681817 IC50 100.0 nM
COC(=O)COc1cc(Br)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681653 IC50 102.0 nM
O=C1CCCCN1CCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676762 IC50 104.0 nM
Cn1cc(-c2cc(O)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681752 IC50 105.0 nM
OCCn1cc(-c2cc(CO)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681801 IC50 105.0 nM
Cc1cc(C(=O)N2CC(OCC(N)=O)C2)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3676699 IC50 109.0 nM
O=C(O)Cn1cc(-c2cc(F)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681739 IC50 109.0 nM
O=C(c1cc(CO)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CCCC1 CHEMBL3681760 IC50 109.0 nM
O=C(O)Cn1cc(-c2cc(Cl)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681711 IC50 110.0 nM
Cn1cc(-c2cc(CO)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681758 IC50 110.0 nM
O=S(=O)(c1ccc(O)cc1O)N1Cc2ccc(NC3CCNCC3)cc2C1 CHEMBL4091824 Kd 110.0 nM
CN(C)C(=O)c1ccc(N(Cc2ccc([N+](=O)[O-])cc2)C(=O)c2ccc(O)cc2O)cc1 CHEMBL4539698 IC50 110.0 nM
CNC(=O)COc1cc(Br)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681640 IC50 112.0 nM
CN(C)C(=O)c1ccc(N(Cc2ccc(F)cc2)C(=O)c2ccc(O)cc2O)cc1 CHEMBL4558944 IC50 113.0 nM
OC1(C(F)(F)F)c2ccccc2-c2c(-c3cncnc3)cccc21 CHEMBL3676647 IC50 114.0 nM
O=C(c1cc(-c2cncnc2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CCCC1 CHEMBL3676717 IC50 114.0 nM
O=C(O)CCn1cc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681682 IC50 117.0 nM
CC(=O)N(C)CCOc1cnc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676744 IC50 119.0 nM
CN(C)C(=O)Cn1cc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681691 IC50 119.0 nM
Cn1cc(-c2cc(C(=O)NCCCCO)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3676692 IC50 121.0 nM
OC1(C(F)(F)F)c2ccccc2-c2c(-c3cn[nH]c3)cccc21 CHEMBL3676625 IC50 125.0 nM
O=C(c1cc(Cl)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CC(CO)C1 CHEMBL3676677 IC50 125.0 nM
Cc1cc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)ccn1 CHEMBL3671780 IC50 126.0 nM
NC(=O)COC1CN(C(=O)c2cc(Cl)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)C1 CHEMBL3676696 IC50 126.0 nM
CN(C)C(=O)c1ccc(N(Cc2ccc(Cl)cc2)C(=O)c2ccc(O)cc2O)cc1 CHEMBL4534284 IC50 126.0 nM
CC(C)(C)n1cc(-c2cc(CO)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681821 IC50 127.0 nM
O=C(c1cc(CO)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CC(O)C1 CHEMBL3681827 IC50 130.0 nM
Cc1nc2[nH]c3c(C4CC4)cccc3c2cc1-c1nnc(C(C)C)o1 CHEMBL5071248 IC50 130.0 nM
CN(C)C(=O)c1ccc(N(Cc2cnc(Br)s2)C(=O)c2ccc(O)cc2O)cc1 CHEMBL4452536 IC50 132.0 nM
Cn1cc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3676611 IC50 133.0 nM
O=C(O)CCCn1cc(-c2cc(CO)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681808 IC50 133.0 nM
CN(C)C(=O)c1ccc(N(Cc2ccco2)C(=O)c2ccc(O)cc2O)cc1 CHEMBL4570690 IC50 133.0 nM
CN(C)C(=O)c1ccc(N(Cc2ccc(C(F)(F)F)cc2)C(=O)c2ccc(O)cc2O)cc1 CHEMBL4470843 IC50 140.0 nM
CCOC(=O)c1ccc(-c2cc(Cl)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cc1 CHEMBL3676581 IC50 142.0 nM
CNC(=O)c1ccc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cc1Cl CHEMBL3676588 IC50 149.0 nM
CN(CCOc1cnc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)C(=O)CO CHEMBL3676745 IC50 149.0 nM
CN(C)C(=O)c1ccc(N(C)C(=O)c2ccc(O)cc2O)cc1 CHEMBL4089806 Ki 150.0 nM
CN(C)C(=O)c1ccc(N(Cc2ccc(O)cc2)C(=O)c2ccc(O)cc2O)cc1 CHEMBL4540811 IC50 150.0 nM
OC1(C(F)(F)F)c2ccccc2-c2ccc(-c3ccncc3)cc21 CHEMBL3671687 IC50 151.0 nM
Cc1cc(C(=O)N2CC(O)C2)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3676697 IC50 152.0 nM
NC(=O)CCCOc1cc(Cl)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676756 IC50 154.0 nM
O=S(=O)(c1ccc(O)cc1O)N1Cc2ccc(NC3CCN(CC(O)CO)CC3)cc2C1 CHEMBL4066580 IC50 154.0 nM
NC(=O)C[C@H](N)C(=O)N1CC[C@H](Nc2ccc3c(c2)CN(S(=O)(=O)c2ccc(O)cc2O)C3)C1 CHEMBL4087901 IC50 156.0 nM
O=S(=O)(c1ccc(O)cc1O)N1Cc2cc(O)cc(O)c2C1 CHEMBL4082531 Kd 156.0 nM
O=C(c1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CC(C(=O)N2CCCC2)C1 CHEMBL3671783 IC50 162.0 nM
Cc1cc(C(=O)N2CC(CO)C2)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3676698 IC50 168.0 nM
O=C1OCCCN1CCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681671 IC50 168.0 nM
COC(=O)c1cc(Cl)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3671646 IC50 169.0 nM
O=C1CCCN1CCCc1cc(CO)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681838 IC50 172.0 nM
O=C(c1cnc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CCC1 CHEMBL3676561 IC50 173.0 nM
COC(=O)C1CN(C(=O)c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)C1 CHEMBL3671704 IC50 174.0 nM
Cn1cc(-c2cc(C(=O)N3CCC[C@H]3CO)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3676739 IC50 176.0 nM
S=C(SSC(=S)N1CCOCC1)N1CCOCC1 CHEMBL121556 Ki 176.0 nM
OCCCCCCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676645 IC50 177.0 nM
O=C(c1cc(Cl)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CC(O)C1 CHEMBL3676686 IC50 177.0 nM
NC(=O)c1ccc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cc1Cl CHEMBL3676587 IC50 178.0 nM
COC(=O)c1cc(-c2cncnc2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676711 IC50 178.0 nM
OCCCCCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676643 IC50 180.0 nM
CN(C)C(=O)c1cc(-c2cncnc2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676715 IC50 180.0 nM
CN(C)C(=O)c1ccc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cc1 CHEMBL3671774 IC50 182.0 nM
NC(=O)c1ccc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cc1 CHEMBL3671781 IC50 182.0 nM
Cn1cc(-c2cc(CCO)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681826 IC50 184.0 nM
CN(C)C(=O)c1ccc(N(CC2CCCCC2)C(=O)c2ccc(O)cc2O)cc1 CHEMBL4579724 IC50 184.0 nM
O=C1OCCN1CCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681660 IC50 185.0 nM
O=C1CCCN1CCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676706 IC50 187.0 nM
Cn1cc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3676724 IC50 189.0 nM
OC1(C(F)(F)F)c2ccccc2-c2ccc(-c3cnco3)cc21 CHEMBL3676593 IC50 190.0 nM
CCc1nnc(-c2cc3c(nc2C)[nH]c2c(C4CC4)cccc23)o1 CHEMBL5078217 IC50 190.0 nM
O=C1NCCN1CCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681670 IC50 193.0 nM
CN(C)C(=O)c1ccc(N(Cc2ccc(Cl)o2)C(=O)c2ccc(O)cc2O)cc1 CHEMBL4587341 IC50 193.0 nM
O=C(c1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CCC1 CHEMBL3671643 IC50 195.0 nM
O=C(O)CCCOc1cc(Br)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676750 IC50 195.0 nM
C#Cc1cc(C(N)=O)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681815 IC50 195.0 nM
CC(=O)N(C)CCn1cc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681723 IC50 197.0 nM
CN(CCO)C(=O)c1cc(-c2cnn(C)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676693 IC50 200.0 nM
Cn1cc(-c2cc(C(=O)N3CCC[C@@H]3CO)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3676738 IC50 200.0 nM
CN1C(=O)CC[C@@H]1COc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681649 IC50 202.0 nM
CN(CCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)C(=O)OC(C)(C)C CHEMBL3676671 IC50 203.0 nM
CN(C)C(=O)c1ccc(N(Cc2ccccc2)C(=O)c2ccc(O)cc2O)cc1 CHEMBL3729572 IC50 206.0 nM
COC(=O)c1cc2c(nc1C)[nH]c1c(C3CC3)cccc12 CHEMBL5073515 IC50 210.0 nM
OC1(C(F)(F)F)c2ccccc2-c2c(-c3cccnc3)cccc21 CHEMBL3671728 IC50 213.0 nM
N#Cc1ccc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cc1 CHEMBL3676572 IC50 214.0 nM
CNC(=O)c1ccc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cc1 CHEMBL3671773 IC50 216.0 nM
O=C(O)CCCCOc1cc(Cl)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676731 IC50 219.0 nM
CN(C)C(=O)c1cccc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)c1 CHEMBL3671740 IC50 221.0 nM
NC(=O)C[C@H](N)C(=O)N1CC[C@@H](Nc2ccc3c(c2)CN(S(=O)(=O)c2ccc(O)cc2O)C3)C1 CHEMBL4104250 IC50 221.0 nM
O=C1COCCN1CCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681686 IC50 223.0 nM
CN1C(=O)CCC1COc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676766 IC50 225.0 nM
CN(C)C(=O)CCCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676630 IC50 226.0 nM
CN(C)C(=O)C1CN(C(=O)c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)C1 CHEMBL3671709 IC50 227.0 nM
Cn1cc(-c2cc(C#CCO)c3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cn1 CHEMBL3681790 IC50 228.0 nM
CC(C)(C)OC(=O)N1CCN(c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)CC1 CHEMBL3671745 IC50 232.0 nM
O=C1CCC(COc2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)N1CCCO CHEMBL3676767 IC50 233.0 nM
NC(=O)COc1cc(Cl)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676732 IC50 234.0 nM
CN(C)C(=O)CCCCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676646 IC50 235.0 nM
CCN(CC)C(=O)C1CN(C(=O)c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)C1 CHEMBL3671782 IC50 236.0 nM
NC(=O)c1cc(Cl)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3681819 IC50 239.0 nM
COC(=O)c1cc(C)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3671630 IC50 247.0 nM
O=C(c1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CC(C(=O)N2CCCCC2)C1 CHEMBL3671784 IC50 247.0 nM
O=C1CCC(COc2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)N1CCO CHEMBL3681635 IC50 247.0 nM
COCOCCN1C(=O)CCC1COc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676777 IC50 250.0 nM
COC(=O)COc1cc(Cl)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681678 IC50 251.0 nM
O=C(O)c1ccc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cc1Cl CHEMBL3676586 IC50 252.0 nM
Cc1ccc(CN(C(=O)c2ccc(O)cc2O)c2ccc(C(=O)N(C)C)cc2)o1 CHEMBL4558837 IC50 252.0 nM
CCCOC1CN(C(=O)c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)C1 CHEMBL3671689 IC50 259.0 nM
Cc1ncc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)o1 CHEMBL3676623 IC50 278.0 nM
CCOC1CN(C(=O)c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)C1 CHEMBL3671688 IC50 279.0 nM
CC(C)(C)C(=O)N1CCN(c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)CC1 CHEMBL3676557 IC50 281.0 nM
CC(=O)Nc1ccc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cc1 CHEMBL3671779 IC50 298.0 nM
OC1(C(F)(F)F)c2ccccc2-c2c(Cl)cc(Cl)cc21 CHEMBL3671606 IC50 302.0 nM
CN(C)C(=O)c1ccc(N(Cc2ccc(C#N)cc2)C(=O)c2ccc(O)cc2O)cc1 CHEMBL4561336 IC50 302.0 nM
CC(=O)N(C)CCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676673 IC50 303.0 nM
COC(=O)c1cccc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)c1 CHEMBL3671736 IC50 309.0 nM
OC1(C(F)(F)F)c2ccccc2-c2c(Cl)cc(-c3ccccc3)cc21 CHEMBL3671741 IC50 318.0 nM
OC1(C(F)(F)F)c2ccccc2-c2ccc(-c3cccnc3)cc21 CHEMBL3639705 IC50 323.0 nM
O=S1(=O)CCCN1CCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681669 IC50 327.0 nM
OCCCCOc1cc(CO)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681797 IC50 329.0 nM
OCC(CO)c1noc(-c2cc(F)cc3c2-c2ccccc2C3(O)C(F)(F)F)n1 CHEMBL3681850 IC50 338.0 nM
OC1(C(F)(F)F)c2ccccc2-c2c(Br)cc(Cl)cc21 CHEMBL3676620 IC50 342.0 nM
N#Cc1cccc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)c1 CHEMBL3676562 IC50 345.0 nM
CC(=O)N(CCO)CCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676726 IC50 351.0 nM
Cc1nc(N2CCC[C@H]2CO)c2c(n1)[nH]c1c(C3CC3)cccc12 CHEMBL5094187 IC50 352.0 nM
COC(=O)c1ccc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cc1Cl CHEMBL3676584 IC50 355.0 nM
NC(=O)C[C@H](N)C(=O)NCCNc1ccc2c(c1)CN(S(=O)(=O)c1ccc(O)cc1O)C2 CHEMBL4102687 IC50 357.0 nM
CNC(=O)c1cccc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)c1 CHEMBL3671739 IC50 358.0 nM
CC(C)(C)OC(=O)NCCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676670 IC50 362.0 nM
OCc1ccc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cc1 CHEMBL3671776 IC50 368.0 nM
CN(C)C(=O)c1ccc(N(Cc2ccc3ccccc3c2)C(=O)c2ccc(O)cc2O)cc1 CHEMBL4533214 IC50 373.0 nM
COC1CN(C(=O)c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)C1 CHEMBL3671671 IC50 378.0 nM
CN1C(=O)CC[C@H]1COc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681650 IC50 381.0 nM
O=C(O)c1ccc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cc1 CHEMBL3671770 IC50 383.0 nM
Cc1ccc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3676621 IC50 396.0 nM
OC1(C(F)(F)F)c2ccccc2-c2c(Cl)cc(F)cc21 CHEMBL3681719 IC50 397.0 nM
OC1(C(F)(F)F)c2ccccc2-c2c(-c3cnco3)cccc21 CHEMBL3671677 IC50 405.0 nM
O=S(=O)(c1ccc(O)cc1O)N1Cc2ccc(NC3CCN(Cc4ccccc4)CC3)cc2C1 CHEMBL4080620 IC50 416.0 nM
COC(=O)COC1CN(C(=O)c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)C1 CHEMBL3671699 IC50 417.0 nM
Cc1cc(Cl)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681714 IC50 418.0 nM
O=C(c1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CC(C(=O)N2CCC(O)CC2)C1 CHEMBL3671785 IC50 423.0 nM
O=C(COc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CCC(CO)CC1 CHEMBL3676743 IC50 424.0 nM
O=S(=O)(c1ccc(O)cc1O)N1Cc2ccc(O)cc2C1 CHEMBL4062355 Kd 426.0 nM
O=C(C1C[C@@H](O)C(O)[C@H](O)C1)N1CCC(Nc2ccc3c(c2)CN(S(=O)(=O)c2ccc(O)cc2O)C3)CC1 CHEMBL4097134 IC50 432.0 nM
O=C(O)CCCOc1cc(Cl)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681677 IC50 433.0 nM
O=C(COc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CCCCC1 CHEMBL3676708 IC50 436.0 nM
O=C1CCC(CO)N1CCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681652 IC50 442.0 nM
NC(=O)CCCCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676653 IC50 453.0 nM
Cc1cc(C)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3671603 IC50 457.0 nM
COCCOC1CN(C(=O)c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)C1 CHEMBL3671690 IC50 461.0 nM
O=C(c1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CC(OCCO)C1 CHEMBL3671692 IC50 462.0 nM
NC(=O)c1cccc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)c1 CHEMBL3671738 IC50 464.0 nM
CC1CCN1C(=O)c1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3671675 IC50 474.0 nM
Cc1cnc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3671778 IC50 475.0 nM
O=C(COc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CCC1 CHEMBL3676737 IC50 485.0 nM
COC(=O)c1cccc2c1-c1cc(F)ccc1C2(O)C(F)(F)F CHEMBL3676568 IC50 488.0 nM
Cc1nnc(-c2cc3c(nc2C)[nH]c2c(C4CC4)cccc23)o1 CHEMBL5083573 IC50 490.0 nM
CC(=O)N(C)C(C)COc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676728 IC50 495.0 nM
O=C(c1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CC(C(=O)N2CCC(O)C2)C1 CHEMBL3676684 IC50 499.0 nM
CC(=O)Nc1ccc(CN(C(=O)c2ccc(O)cc2O)c2ccc(C(=O)N(C)C)cc2)cc1 CHEMBL4470078 IC50 503.0 nM
O=C1CCC(COc2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)N1 CHEMBL3676765 IC50 504.0 nM
C#Cc1cc(CO)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681824 IC50 510.0 nM
CC(O)c1cc(-c2cnn(CCO)c2)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3681774 IC50 513.0 nM
OCc1cc(Cl)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3681818 IC50 515.0 nM
CCOC(=O)c1ccc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cc1 CHEMBL3671757 IC50 517.0 nM
OCCCCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676618 IC50 533.0 nM
O=C(O)Cn1cc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 CHEMBL3681680 IC50 542.0 nM
Cc1noc(-c2cccc3c2-c2ccccc2C3(O)C(F)(F)F)n1 CHEMBL3671724 IC50 543.0 nM
Cc1noc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)n1 CHEMBL3676595 IC50 547.0 nM
O=C(COc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CCCC1 CHEMBL3676707 IC50 548.0 nM
CN(C)C(=O)C1CCN(C(=O)c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)C1 CHEMBL3676577 IC50 552.0 nM
O=C(O)CCCCCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676665 IC50 553.0 nM
O=C1CCCCN1CCCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676747 IC50 554.0 nM
Nc1ccc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cc1 CHEMBL3671775 IC50 560.0 nM
CCc1cc(C(N)=O)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681816 IC50 560.0 nM
NC(=O)COc1cnc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681636 IC50 561.0 nM
CNC(=O)CCCCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676652 IC50 562.0 nM
CN(CCO)C(=O)c1cc(-c2cncnc2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676719 IC50 564.0 nM
O=C1CC[C@@H](COc2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)N1 CHEMBL3681648 IC50 565.0 nM
O=C(O)c1ccccc1C(=O)N1CCC(Nc2ccc3c(c2)CN(S(=O)(=O)c2ccc(O)cc2O)C3)CC1 CHEMBL4095603 IC50 565.0 nM
O=C(c1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CCCC1 CHEMBL3671638 IC50 567.0 nM
CCOC(=O)CCCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676605 IC50 567.0 nM
COC(=O)c1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3671608 IC50 571.0 nM
CCOC(=O)CCCCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676631 IC50 571.0 nM
NCCCC[C@H](N)C(=O)N1CCC(Nc2ccc3c(c2)CN(S(=O)(=O)c2ccc(O)cc2O)C3)CC1 CHEMBL4075193 IC50 580.0 nM
CNc1cccc2c1NC(=O)C2(C)C CHEMBL4848983 IC50 590.0 nM
NC(=O)COC1CN(C(=O)c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)C1 CHEMBL3671700 IC50 601.0 nM
O=C1CC[C@H](COc2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)N1 CHEMBL3681647 IC50 605.0 nM
O=C(NCCCCO)c1cc(-c2cncnc2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676718 IC50 617.0 nM
O=C(c1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CCC(CO)C1 CHEMBL3676573 IC50 619.0 nM
CC(=O)c1cccc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3671653 IC50 624.0 nM
OC1(C(F)(F)F)c2ccccc2-c2ncc(Cl)cc21 CHEMBL3671621 IC50 626.0 nM
O=C(COc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CCC(O)CC1 CHEMBL3676742 IC50 627.0 nM
O=C(O)CCCCCCCC(=O)N1CCC(Nc2ccc3c(c2)CN(S(=O)(=O)c2ccc(O)cc2O)C3)CC1 CHEMBL4069937 IC50 629.0 nM
CN(CCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)C(=O)CO CHEMBL3676695 IC50 634.0 nM
NC(=O)COc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676636 IC50 635.0 nM
CCOC(=O)c1cccc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3671633 IC50 639.0 nM
CNC(=O)COc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3639755 IC50 641.0 nM
CC(O)c1cc(-c2cnn(C)c2)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3681785 IC50 653.0 nM
O=C(c1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CC(CO)C1 CHEMBL3671672 IC50 669.0 nM
CC(=O)N(C)CCCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676681 IC50 674.0 nM
COc1cc(C(N)=O)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3681811 IC50 674.0 nM
CC(C)C(=O)N1CCN(c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)CC1 CHEMBL3671789 IC50 677.0 nM
CC(C)OC(=O)N1CCN(c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)CC1 CHEMBL3676560 IC50 685.0 nM
OC1(C(F)(F)F)c2ccccc2-c2ccc(-c3cccc(Cl)c3)cc21 CHEMBL3671716 IC50 694.0 nM
O=C(c1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CC(O)C1 CHEMBL3671664 IC50 696.0 nM
O=C1CCCN1CCCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676741 IC50 699.0 nM
COC[C@@H]1COCCN1C(=S)SSC(=S)N1CCOC[C@H]1COC CHEMBL4092859 Ki 702.0 nM
COc1cnc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676725 IC50 703.0 nM
Oc1ccc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cc1 CHEMBL3671786 IC50 707.0 nM
CCCCCCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676641 IC50 710.0 nM
Cc1cnc2[nH]c3c(C4CC4)cccc3c2n1 CHEMBL4855768 IC50 710.0 nM
Cc1ncc2c(n1)[nH]c1c(C3CC3)cccc12 CHEMBL5082649 IC50 710.0 nM
O=C(c1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)c1cccs1 CHEMBL3671684 IC50 718.0 nM
CCCCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676597 IC50 719.0 nM
COC(=O)C1CCN1C(=O)c1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676651 IC50 723.0 nM
NC(=O)c1cc(OCCO)cc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3681823 IC50 732.0 nM
CNC(=O)C1CN(C(=O)c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)C1 CHEMBL3671708 IC50 736.0 nM
CN(C)C(=O)CCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676650 IC50 755.0 nM
CCC1CCCN1c1nc(C)nc2[nH]c3c(C4CC4)cccc3c12 CHEMBL5075866 IC50 758.0 nM
NC(=O)C[C@H](N)C(=O)N1CCN(c2ccc3c(c2)CN(S(=O)(=O)c2ccc(O)cc2O)C3)CC1 CHEMBL4096523 IC50 767.0 nM
CCCOC(=O)c1cccc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3671644 IC50 772.0 nM
CN(C)C(=O)c1ccc(N(CC(C)(C)C)C(=O)c2ccc(O)cc2O)cc1 CHEMBL4543303 IC50 772.0 nM
COc1ccc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)cc1 CHEMBL3671754 IC50 779.0 nM
CN(C)C(=O)COc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676637 IC50 793.0 nM
COc1nc2c(cc1C(=O)N1CCC1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676583 IC50 803.0 nM
O=C(O)c1cccc(-c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)c1 CHEMBL3671737 IC50 805.0 nM
CC(=O)N(C)C1CCN(C(=O)c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)C1 CHEMBL3676594 IC50 809.0 nM
O[C@H]1CCN(CCOc2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)C1 CHEMBL3639756 IC50 822.0 nM
CN(C)C(=O)COC1CN(C(=O)c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)C1 CHEMBL3671702 IC50 839.0 nM
COC(=O)c1cccc2c1-c1ccccc1C2(O)C(F)(F)F CHEMBL3671612 IC50 848.0 nM
OC1(C(F)(F)F)c2ccccc2-c2ccc(-c3ccccc3)cc21 CHEMBL3671682 IC50 849.0 nM
O=C(O)CCCCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676642 IC50 861.0 nM
CCCCCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676626 IC50 862.0 nM
O=C(COc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2)N1CCC[C@@H]1CO CHEMBL3676729 IC50 863.0 nM
OC1(C(F)(F)F)c2ccccc2-c2ccc(-c3cccc(F)c3)cc21 CHEMBL3671713 IC50 864.0 nM
NC(=O)C1CN(C(=O)c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)C1 CHEMBL3671707 IC50 877.0 nM
CNC(=O)COC1CN(C(=O)c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)C1 CHEMBL3671701 IC50 909.0 nM
CNCCCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676679 IC50 912.0 nM
CN(C)CCCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676680 IC50 924.0 nM
OC1(C(F)(F)F)c2ccccc2-c2ccc(-c3ccc(F)cc3)cc21 CHEMBL3671753 IC50 951.0 nM
O[C@@H]1CCN(CCOc2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)C1 CHEMBL3676736 IC50 954.0 nM
CC(=O)N1CCN(c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)CC1 CHEMBL3671747 IC50 957.0 nM
OC1(C(F)(F)F)c2ccccc2-c2ccc(-n3cccn3)cc21 CHEMBL3681748 IC50 970.0 nM
CCC(=O)N1CCN(c2ccc3c(c2)C(O)(C(F)(F)F)c2ccccc2-3)CC1 CHEMBL3671788 IC50 998.0 nM
CNC(=O)CCCOc1ccc2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 CHEMBL3676629 IC50 1000.0 nM