CC(C)n1cc(C(=O)c2cncc(N[C@@H]3CCC[C@@H]3c3ccc(F)cc3)n2)c2c(N)ncnc21 CHEMBL1940246 Ki 0.6 nM
CC(C)n1cc(C(=O)c2cncc(N[C@@H]3COC[C@@H]3c3ccc(F)cc3)n2)c2c(N)ncnc21 CHEMBL1938415 Ki 0.6 nM
C[C@@H]1C[C@@H](N(C)C(=O)CC(C)(C)C)CN(c2cc(-c3ccc4c(N)n[nH]c4c3)nc(N)n2)C1 CHEMBL1765751 pIC50 0.631 nM
CC(C)n1cc(C(=O)c2cncc(N[C@@H]3CCN(C=O)[C@@H]3c3ccc(F)cc3)n2)c2c(N)ncnc21 CHEMBL1940251 Ki 0.7 nM
CNc1nc(-c2ccc3c(N)n[nH]c3c2)cc(N2C[C@H](C)C[C@@H](N(C)C(=O)OC(C)(C)C)C2)n1 CHEMBL1765750 pIC50 0.7943 nM
CC(C)n1cc(C(=O)c2cncc(N(C)[C@@H]3CCC[C@@H]3c3ccc(F)cc3)n2)c2c(N)ncnc21 CHEMBL1940247 Ki 0.9 nM
O=C(N[C@@H](COc1ccc2[nH]c(=O)[nH]c2c1)c1ccccc1)c1cccn(Cc2ccc(F)c(F)c2)c1=O CHEMBL1234429 EC50 1.0 nM
CC(C)n1cc(C(=O)c2cncc(N[C@@H]3CCN[C@@H]3c3ccc(F)cc3)n2)c2c(N)ncnc21 CHEMBL1940250 Ki 1.0 nM
CCN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cccn([C@@H](CO)c5ccc(F)c(F)c5)c4=O)cc3n2)CC1 CHEMBL3689220 IC50 1.0 nM
CN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c2)CC1 CHEMBL3689239 IC50 1.0 nM
CCN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cccn([C@@H](C)c5ccc(F)c(F)c5)c4=O)cc3c2)CC1 CHEMBL3689244 IC50 1.0 nM
O=C(NCC#Cc1ccc2ncc3nc[nH]c3c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3644680 IC50 1.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn([C@H](CO)c5cccc(F)c5)c4=O)cc3c2n1C(C)C CHEMBL3644700 IC50 1.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn([C@@H](C)c5ccc(F)c(F)c5)c4=O)cc3c2n1C(C)C CHEMBL3644710 IC50 1.0 nM
COc1cc(C(=O)NCC#Cc2ccc3ncc4nc(C)n(C(C)C)c4c3c2)c(=O)n(Cc2ccc(F)c(F)c2)n1 CHEMBL3644712 IC50 1.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn([C@@H](C)c5ccc(F)c(F)c5)c4=O)cc3c2n1[C@H]1CC[C@@H](N(C)C)CC1 CHEMBL3644732 IC50 1.0 nM
CN1CCC(n2cnc3cnc4ccc(C#CCNC(=O)c5cc(Cl)nn(Cc6ccc(F)c(F)c6)c5=O)cc4c32)CC1 CHEMBL3644741 IC50 1.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn([C@@H](C)c5ccc(F)c(F)c5)c4=O)cc3c2n1[C@H]1CC[C@H](N(C)C)CC1 CHEMBL3644750 IC50 1.0 nM
CN(C)[C@H]1CC[C@H](n2cnc3cnc4ccc(C#CCNC(=O)c5cccn([C@@H](CO)c6cccc(F)c6)c5=O)cc4c32)CC1 CHEMBL3644753 IC50 1.0 nM
CCn1cnc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c21 CHEMBL3644758 IC50 1.0 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 1.259 nM
CC(C)n1cc(C(=O)c2cncc(N[C@@H]3CCO[C@@H]3c3ccc(F)cc3)n2)c2c(N)ncnc21 CHEMBL1940248 Ki 1.3 nM
CC(=O)N1CC[C@@H](Nc2cncc(C(=O)c3cn(C(C)C)c4ncnc(N)c34)n2)[C@H]1c1ccc(F)cc1 CHEMBL1940252 Ki 1.4 nM
CC(=O)N1CC[C@@H](Nc2cncc(C(=O)c3cn(C(C)C)c4ncnc(N)c34)n2)[C@H]1c1ccccc1 CHEMBL1940253 Ki 1.4 nM
CNc1nc(-c2ccc3c(N)n[nH]c3c2)cc(N2C[C@@H](C(=O)Nc3ccccc3)CC[C@H]2C)n1 CHEMBL1765738 pIC50 1.585 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 1.585 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 Kd 1.7 nM
CC(C)n1cc(C(=O)c2cncc(N[C@@H]3CCC[C@@H]3c3ccccc3)n2)c2c(N)ncnc21 CHEMBL1940245 Ki 2.0 nM
C[C@H](c1ccc(F)c(F)c1)n1cccc(C(=O)NCC#Cc2ccc3ncc(NC4CCN(C)CC4)nc3c2)c1=O CHEMBL3689201 IC50 2.0 nM
O=C(NCC#Cc1ccc2ncc(N[C@H]3CC[C@H](N4CCOCC4)CC3)nc2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689210 IC50 2.0 nM
CCN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cncn([C@@H](C)c5ccc(F)c(F)c5)c4=O)cc3n2)CC1 CHEMBL3689221 IC50 2.0 nM
O=C(NCC#Cc1ccc2ncc(N[C@H]3CC[C@H](N4CCN(CC5CC5)CC4)CC3)nc2c1)c1cccn([C@H](CO)c2cccc(F)c2)c1=O CHEMBL3689231 IC50 2.0 nM
O=C(NCC#Cc1ccc2ncc(N[C@H]3CC[C@H](N4CCN(CC5CC5)CC4)CC3)nc2c1)c1ccnn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689232 IC50 2.0 nM
CCN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)cc3c2)CC1 CHEMBL3689241 IC50 2.0 nM
CCN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cccn([C@H](CO)c5cccc(F)c5)c4=O)cc3c2)CC1 CHEMBL3689245 IC50 2.0 nM
O=C(NCC#Cc1ccc2nccc(OCC3CCCNC3)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689292 IC50 2.0 nM
CC(c1ccc(F)c(F)c1)n1cccc(C(=O)NCC#Cc2ccc3nccc(OCCCN(C)C)c3c2)c1=O CHEMBL3689293 IC50 2.0 nM
CN(C)CCCOc1ccnc2ccc(C#CCNC(=O)c3cccn(C(CO)c4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689294 IC50 2.0 nM
CN1CC[C@H](COc2ccnc3ccc(C#CCNC(=O)c4cccn(Cc5cc(F)c(F)c(F)c5)c4=O)cc23)C1 CHEMBL3689303 IC50 2.0 nM
CN1CCC[C@@H](COc2ccnc3ccc(C#CCNC(=O)c4cccn(Cc5cc(F)c(F)c(F)c5)c4=O)cc23)C1 CHEMBL3689310 IC50 2.0 nM
CC(c1cc(F)c(F)c(F)c1)n1cccc(C(=O)NCC#Cc2ccc3nccc(OC[C@@H]4CCCN(C)C4)c3c2)c1=O CHEMBL3689311 IC50 2.0 nM
CN1CCC[C@@H](COc2ccnc3ccc(C#CCNC(=O)c4cccn(C(CO)c5cc(F)c(F)c(F)c5)c4=O)cc23)C1 CHEMBL3689314 IC50 2.0 nM
O=C(NCC#Cc1ccc2ncc3ncn(CCCO)c3c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3644683 IC50 2.0 nM
CN1CCC(n2cnc3cnc4ccc(C#CCNC(=O)c5cncn(Cc6ccc(F)c(F)c6)c5=O)cc4c32)CC1 CHEMBL3644689 IC50 2.0 nM
Cc1cc(C(=O)NCC#Cc2ccc3ncc4nc(C)n(C(C)C)c4c3c2)c(=O)n([C@H](C)c2ccc(F)c(F)c2)n1 CHEMBL3644695 IC50 2.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)cc3c2n1C(C)C CHEMBL3644697 IC50 2.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn([C@H](CO)c5ccc(F)c(F)c5)c4=O)cc3c2n1C(C)C CHEMBL3644703 IC50 2.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c2n1C(C)C CHEMBL3644704 IC50 2.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn([C@@H](CO)c5ccccc5)c4=O)cc3c2n1C(C)C CHEMBL3644713 IC50 2.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn([C@@H](CN)c5ccc(F)c(F)c5)c4=O)cc3c2n1C(C)C CHEMBL3644722 IC50 2.0 nM
CC(C)N1CCC(n2cnc3cnc4ccc(C#CCNC(=O)c5cccn([C@@H](C)c6ccc(F)c(F)c6)c5=O)cc4c32)CC1 CHEMBL3644729 IC50 2.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn([C@@H](C)c5ccc(F)c(F)c5)c4=O)cc3c2n1C1CCN(C)CC1 CHEMBL3644733 IC50 2.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c2n1C1CCCOC1 CHEMBL3644755 IC50 2.0 nM
CC(C)n1cnc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c21 CHEMBL3639436 IC50 2.0 nM
CCn1c(C)nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c21 CHEMBL3644759 IC50 2.0 nM
O=C(NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1Br)c1cccs1 CHEMBL2207217 IC50 2.3 nM
CNc1nc(-c2ccc3c(N)n[nH]c3c2)cc(N2C[C@@H](C(=O)NC3CCCCC3)CC[C@H]2C)n1 CHEMBL1765740 IC50 2.5 nM
CC(C)n1cc(C(=O)c2cncc(N[C@@H]3CNC[C@@H]3c3ccc(F)cc3)n2)c2c(N)ncnc21 CHEMBL1940249 Ki 2.5 nM
Cn1cc(-c2cnc3[nH]cc(-c4cc(N(CCO)c5ccccc5Cl)nc(N)n4)c3c2)cn1 CHEMBL3652573 IC50 2.6 nM
CC/C(=C1/C(=O)Nc2ccc(NC(N)=O)cc21)c1ccc[nH]1 CHEMBL232176 IC50 3.0 nM
COc1cc2ncc3c(N)nc(-c4cncc(OC[C@@H](C)N)c4)cc3c2cc1OC CHEMBL1097955 IC50 3.0 nM
CC[C@@H](N)COc1cncc(-c2cc3c(cnc4cc(OC)c(OC)cc43)c(N)n2)c1 CHEMBL1094320 IC50 3.0 nM
COc1cc2ncc3c(N)nc(-c4cncc(OC[C@@H](N)Cc5ccc(F)cc5)c4)cc3c2cc1OC CHEMBL1095621 IC50 3.0 nM
O=C(NCC#Cc1ccc2ncc(NC3CCN(CCO)CC3)nc2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3640540 IC50 3.0 nM
O=C(NCC#Cc1ccc2ncc(NC3CCNCC3)nc2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689198 IC50 3.0 nM
N[C@H]1CC[C@H](Nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3n2)CC1 CHEMBL3689205 IC50 3.0 nM
CN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cccn([C@@H](CO)c5ccc(F)c(F)c5)c4=O)cc3n2)CC1 CHEMBL3689211 IC50 3.0 nM
O=C(NCC#Cc1ccc2ncc(N[C@H]3CC[C@H](N4CCN(CC5CC5)CC4)CC3)nc2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689212 IC50 3.0 nM
COCCN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cccn([C@@H](CO)c5ccc(F)c(F)c5)c4=O)cc3n2)CC1 CHEMBL3689218 IC50 3.0 nM
O=C(NCC#Cc1ccc2ncc(NC3CCN(C4COC4)CC3)nc2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689226 IC50 3.0 nM
O=C(NCC#Cc1ccc2nccc(OCC3CCNC3)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689291 IC50 3.0 nM
CC(c1cc(F)c(F)c(F)c1)n1cccc(C(=O)NCC#Cc2ccc3nccc(OC[C@@H]4CCN(C)C4)c3c2)c1=O CHEMBL3689295 IC50 3.0 nM
CC(c1ccc(F)c(F)c1)n1cccc(C(=O)NCC#Cc2ccc3nccc(OC[C@H]4CCN(C)C4)c3c2)c1=O CHEMBL3689304 IC50 3.0 nM
O=C(NCC#Cc1ccc2nccc(OC[C@@H]3CCCN(CCN4CCOCC4)C3)c2c1)c1cccn(Cc2cc(F)c(F)c(F)c2)c1=O CHEMBL3689312 IC50 3.0 nM
CC(C)N1CCC[C@@H](COc2ccnc3ccc(C#CCNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)cc23)C1 CHEMBL3689315 IC50 3.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn([C@@H](C)c5ccc(F)c(F)c5)c4=O)cc3c2n1C1CCN(C(C)C)CC1 CHEMBL3644724 IC50 3.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn([C@@H](CO)c5cccc(F)c5)c4=O)cc3c2n1[C@H]1CC[C@H](N(C)C)CC1 CHEMBL3644751 IC50 3.0 nM
CN(C)[C@H]1CC[C@@H](n2cnc3cnc4ccc(C#CCNC(=O)c5cccn([C@@H](CO)c6cccc(F)c6)c5=O)cc4c32)CC1 CHEMBL3644754 IC50 3.0 nM
C[C@@H]1CC[C@H](C(=O)Nc2ccccc2)CN1c1cc(-c2ccc3c(N)[nH]nc3c2)nc(N)n1 CHEMBL1614775 pIC50 3.162 nM
CC[C@@H]1CO[C@H](C(=O)Nc2ccccc2)CN1c1cc(-c2ccc3c(N)n[nH]c3c2)nc(NC)n1 CHEMBL1765742 pIC50 3.162 nM
CNc1nc(-c2ccc3c(N)n[nH]c3c2)cc(N2C[C@@H](C(=O)NC3CCCCC3)OC[C@H]2C)n1 CHEMBL1765743 pIC50 3.162 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 3.4 nM
CN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3n2)CC1 CHEMBL3689191 IC50 4.0 nM
CCN1CC[C@H](Nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3n2)[C@H](F)C1 CHEMBL3689217 IC50 4.0 nM
COCCN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cccn([C@@H](C)c5ccc(F)c(F)c5)c4=O)cc3n2)CC1 CHEMBL3689222 IC50 4.0 nM
COCCN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cccn([C@H](CO)c5cccc(F)c5)c4=O)cc3n2)CC1 CHEMBL3689225 IC50 4.0 nM
O=C(NCC#Cc1ccc2ncc(NC3CCN(C4COC4)CC3)nc2c1)c1cccn([C@H](CO)c2cccc(F)c2)c1=O CHEMBL3689233 IC50 4.0 nM
CCN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c2)CC1 CHEMBL3689240 IC50 4.0 nM
COCCN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c2)CC1 CHEMBL3689242 IC50 4.0 nM
COCCN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cccn([C@@H](CO)c5ccc(F)c(F)c5)c4=O)cc3c2)CC1 CHEMBL3689246 IC50 4.0 nM
CC(c1cc(F)c(F)c(F)c1)n1cccc(C(=O)NCC#Cc2ccc3nccc(OC[C@H]4CCN(C)C4)c3c2)c1=O CHEMBL3689305 IC50 4.0 nM
O=C(NCC#Cc1ccc2nccc(OC[C@@H]3CCCNC3)c2c1)c1cccn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689316 IC50 4.0 nM
O=C(NCC#Cc1ccc2ncc3ncn(CCO)c3c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3644681 IC50 4.0 nM
O=C(NCC#Cc1ccc2ncc3ncn(C4CCC4)c3c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3644682 IC50 4.0 nM
CCOc1cc(C(=O)NCC#Cc2ccc3ncc4nc(C)n(C(C)C)c4c3c2)c(=O)n(Cc2ccc(F)c(F)c2)n1 CHEMBL3644699 IC50 4.0 nM
O=C(NCC#Cc1ccc2ncc3nc[nH]c3c2c1)c1cccn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3644736 IC50 4.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn([C@@H](CO)c5cccc(F)c5)c4=O)cc3c2n1[C@H]1CC[C@@H](N(C)C)CC1 CHEMBL3644752 IC50 4.0 nM
Cn1cc(-c2cnc3[nH]cc(-c4cc(N(CCC(=O)O)c5ccccc5Cl)nc(N)n4)c3c2)cn1 CHEMBL3639514 IC50 4.8 nM
C/C(=C1/C(=O)Nc2ccc(NC(N)=O)cc21)c1ccc[nH]1 CHEMBL228654 IC50 5.0 nM
COc1cc2ncc3c(N)nc(-c4cncc(OCCN)c4)cc3c2cc1OC CHEMBL1095278 IC50 5.0 nM
CN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)cc3n2)CC1 CHEMBL3689202 IC50 5.0 nM
COCCN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3n2)CC1 CHEMBL3689208 IC50 5.0 nM
CN(C)[C@H]1CC[C@H](Nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3n2)CC1 CHEMBL3689213 IC50 5.0 nM
O=C(NCC#Cc1ccc2ncc(N[C@H]3CC[C@H](N4CCOCC4)CC3)nc2c1)c1cccn([C@H](CO)c2ccccc2)c1=O CHEMBL3689229 IC50 5.0 nM
O=C(NCC#Cc1ccc2ncc(N[C@H]3CC[C@H](N4CCOCC4)CC3)nc2c1)c1cccn([C@H](CO)c2cccc(F)c2)c1=O CHEMBL3689234 IC50 5.0 nM
CN1CCCC(COc2ccnc3ccc(C#CCNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)cc23)C1 CHEMBL3689270 IC50 5.0 nM
CN(C)CCCOc1ccnc2ccc(C#CCNC(=O)c3cccn(Cc4cc(F)c(F)c(F)c4)c3=O)cc12 CHEMBL3689296 IC50 5.0 nM
CN(C)CCCCOc1ccnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689297 IC50 5.0 nM
Cn1cc(-c2cnc3[nH]cc(-c4cc(N(CCO)c5ccccc5F)nc(N)n4)c3c2)cn1 CHEMBL3652582 IC50 5.0 nM
Cn1cc(-c2cnc3[nH]cc(-c4cc(N5CCOc6ccccc65)nc(N)n4)c3c2)cn1 CHEMBL3652583 IC50 5.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cc(Cl)nn(Cc5ccc(F)c(F)c5)c4=O)cc3c2n1C(C)C CHEMBL3644698 IC50 5.0 nM
CCc1c(C(=O)NCC#Cc2ccc3ncc4nc(C)n(C(C)C)c4c3c2)c(=O)n(Cc2ccc(F)c(F)c2)n1C CHEMBL3644706 IC50 5.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4c(C)n(C)n(C(C)c5ccc(F)c(F)c5)c4=O)cc3c2n1C(C)C CHEMBL3644708 IC50 5.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4c(C)n(C)n(Cc5ccc(F)c(F)c5)c4=O)cc3c2n1C(C)C CHEMBL3644709 IC50 5.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4c(C)n(C)n(Cc5ccc(F)c(F)c5)c4=O)cc3c2n1C1CCOCC1 CHEMBL3644748 IC50 5.0 nM
Cn1cnc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c21 CHEMBL3644757 IC50 5.0 nM
CCOc1cc(C(=O)NCC#Cc2ccc3ncc4ncn(C(C)C)c4c3c2)c(=O)n(Cc2ccc(F)c(F)c2)n1 CHEMBL3644761 IC50 5.0 nM
C[C@@H]1CO[C@H](C(=O)Nc2ccccc2)CN1c1cc(-c2ccc3c(N)n[nH]c3c2)nc(N)n1 CHEMBL1765741 pIC50 5.012 nM
COc1cc2ncc3c(N)nc(-c4cncc(OC[C@H](C)N)c4)cc3c2cc1OC CHEMBL1095279 IC50 6.0 nM
CC[C@H](N)COc1cncc(-c2cc3c(cnc4cc(OC)c(OC)cc43)c(N)n2)c1 CHEMBL1097956 IC50 6.0 nM
COc1cc2ncc3c(N)nc(-c4cncc(OC[C@@H](N)Cc5c[nH]c6ccccc56)c4)cc3c2cc1OC CHEMBL1095612 IC50 6.0 nM
COc1cc2ncc3c(N)nc(-c4cncc(OC[C@@H](N)Cc5ccc(Cl)c(Cl)c5)c4)cc3c2cc1OC CHEMBL1097972 IC50 6.0 nM
CCN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3n2)CC1 CHEMBL3689193 IC50 6.0 nM
CN1CC[C@@H](COc2ccnc3ccc(C#CCNC(=O)c4cccn(Cc5cc(F)c(F)c(F)c5)c4=O)cc23)C1 CHEMBL3689306 IC50 6.0 nM
CCN(CC)CCCOc1ccnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689307 IC50 6.0 nM
CN(Cc1cccc2ncccc12)c1ncnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640483 IC50 6.0 nM
COc1ccc(CN(C)c2ncnc3ccc(C#CCNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)cc23)cc1 CHEMBL3640489 IC50 6.0 nM
CCN(CC)c1ncnc2ccc(C#CCNC(=O)c3cccn([C@H](CO)c4ccccc4)c3=O)cc12 CHEMBL3640493 IC50 6.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)cc3c2n1C1CCN(C)CC1 CHEMBL3644726 IC50 6.0 nM
CN(C)CCCc1nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c2n1C CHEMBL3647298 IC50 6.0 nM
O=C(NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1I)c1cccs1 CHEMBL577784 IC50 6.0 nM
CC[C@@H]1CO[C@H](C(=O)NC2CCCCC2)CN1c1cc(-c2ccc3c(N)n[nH]c3c2)nc(NC)n1 CHEMBL1765744 pIC50 6.31 nM
C[C@@H]1C[C@@H](NC(=O)OC(C)(C)C)CN(c2cc(-c3ccc4c(N)[nH]nc4c3)nc(N)n2)C1 CHEMBL1614777 pIC50 6.31 nM
Cn1cc(-c2cnc3[nH]cc(-c4cc(N(CCO)c5ccc(F)cc5F)nc(N)n4)c3c2)cn1 CHEMBL3652581 IC50 6.5 nM
CCN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)cc3n2)CC1 CHEMBL3689216 IC50 7.0 nM
O=C(NCC#Cc1ccc2ncc(N[C@H]3CC[C@H](N4CCOCC4)CC3)nc2c1)c1ccnn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689230 IC50 7.0 nM
O=C(NCC#Cc1ccc2ncc(N[C@H]3CC[C@H](N4CCN(CC5CC5)CC4)CC3)nc2c1)c1cccn([C@H](CO)c2ccccc2)c1=O CHEMBL3689235 IC50 7.0 nM
COCCN(c1cc(-c2c[nH]c3ncc(-c4cnn(C)c4)cc23)nc(N)n1)c1ccccc1Cl CHEMBL3652585 IC50 7.0 nM
CC(C)N1CCC(n2cnc3cnc4ccc(C#CCNC(=O)c5cccn(Cc6ccc(F)c(F)c6)c5=O)cc4c32)CC1 CHEMBL3644727 IC50 7.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cc(Cl)nn(Cc5ccc(F)c(F)c5)c4=O)cc3c2n1CCc1ccccc1 CHEMBL3644734 IC50 7.0 nM
O=C(NCC#Cc1ccc2ncc3ncn(C4CCOC4)c3c2c1)c1cccn([C@@H](CO)c2cccc(F)c2)c1=O CHEMBL3644749 IC50 7.0 nM
Cn1cc(-c2cnc3[nH]cc(-c4cc(N(CCC#N)c5ccccc5)nc(N)n4)c3c2)cn1 CHEMBL3652586 IC50 7.1 nM
CN(c1cc(-c2c[nH]c3ncc(-c4cnn(C)c4)cc23)nc(N)n1)c1ccccc1Cl CHEMBL3652567 IC50 7.6 nM
C[C@@H]1CC[C@H](C(=O)NC2CCCCC2)CN1c1cc(-c2ccc3c(N)n[nH]c3c2)nc(N)n1 CHEMBL1765739 pIC50 7.943 nM
NC(=O)Cn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL1985095 pKi 7.943 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 pKi 7.943 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 7.943 nM
COc1cc2ncc3c(N)nc(-c4cncc(OC[C@@H](N)Cc5ccccc5)c4)cc3c2cc1OC CHEMBL1097602 IC50 8.0 nM
COc1cc2ncc3c(N)nc(-c4cncc(OC[C@@H](N)Cc5ccccc5Cl)c4)cc3c2cc1OC CHEMBL1095931 IC50 8.0 nM
COc1cc2ncc3c(N)nc(-c4cncc(OC[C@@H](N)Cc5cccc(Cl)c5)c4)cc3c2cc1OC CHEMBL1096271 IC50 8.0 nM
CNc1ncnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)c(C)c12 CHEMBL3640541 IC50 8.0 nM
O=C(NCC#Cc1ccc2ncc(NC3CCN(C4CC4)CC3)nc2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689194 IC50 8.0 nM
CN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cccn([C@H](CO)c5ccccc5)c4=O)cc3n2)CC1 CHEMBL3689203 IC50 8.0 nM
CCN1CC[C@@H](Nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3n2)[C@@H](F)C1 CHEMBL3689215 IC50 8.0 nM
COCCN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4ccnn(Cc5ccc(F)c(F)c5)c4=O)cc3n2)CC1 CHEMBL3689223 IC50 8.0 nM
O=C(NCC#Cc1ccc2ncc(NC3CCN(C4COC4)CC3)nc2c1)c1ccnn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689224 IC50 8.0 nM
C[C@@H](c1ccc(F)c(F)c1)n1cccc(C(=O)NCC#Cc2ccc3ncc(NC4CCN(C5COC5)CC4)nc3c2)c1=O CHEMBL3689228 IC50 8.0 nM
COCCN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)cc3c2)CC1 CHEMBL3689243 IC50 8.0 nM
CCN(CC)c1ncnc2ccc(C#CCNC(=O)c3cc(Cl)nn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640480 IC50 8.0 nM
CCN(CC)c1ncnc2ccc(C#CCNC(=O)c3cccn(C(C)c4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640491 IC50 8.0 nM
CNc1ncnc2ccc(C#CCNC(=O)c3cccn([C@@H](C)c4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640497 IC50 8.0 nM
O=C(NCC#Cc1ccc2ncc3ncn(C4CCNCC4)c3c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3644693 IC50 8.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn(Cc5ccccc5)c4=O)cc3c2n1C(C)C CHEMBL3644696 IC50 8.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)cc3c2n1C1CCN(C(C)C)CC1 CHEMBL3644723 IC50 8.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c2n1C CHEMBL3644760 IC50 8.0 nM
CCc1nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c2n1C CHEMBL3647295 IC50 8.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 8.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 8.0 nM
Cn1cc(-c2cnc3[nH]cc(-c4cc(N(CCCN)c5ccccc5)nc(N)n4)c3c2)cn1 CHEMBL3652588 IC50 8.7 nM
NC(=O)Nc1ccc2c(c1)/C(=C(\c1cccc(N)c1)c1ccc[nH]1)C(=O)N2 CHEMBL391101 IC50 9.0 nM
COc1cc2ncc3c(N)nc(-c4cncc(OC[C@@H](N)Cc5ccncc5)c4)cc3c2cc1OC CHEMBL1097973 IC50 9.0 nM
COCCN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)cc3n2)CC1 CHEMBL3689219 IC50 9.0 nM
O=C(NCC#Cc1ccc2ncc(NC3CCN(C4COC4)CC3)nc2c1)c1cccn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689227 IC50 9.0 nM
COCCN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cccn([C@@H](C)c5ccc(F)c(F)c5)c4=O)cc3c2)CC1 CHEMBL3689247 IC50 9.0 nM
CNc1ncnc2ccc(C#CCNC(=O)c3cc(OC)nn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640496 IC50 9.0 nM
O=C(NCC#Cc1ccc2ncc3ncn([C@H]4CCCNC4)c3c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3644691 IC50 9.0 nM
CN(c1cc(-c2c[nH]c3ncc(-c4cnn(C)c4)cc23)nc(N)n1)c1ccccc1F CHEMBL3652566 IC50 9.7 nM
COc1cccc(-c2c[nH]c(/C=C3\C(=O)Nc4ccc(NC(N)=O)cc43)c2)c1 CHEMBL442227 IC50 10.0 nM
NC(=O)Nc1ccc2c(c1)/C(=C(\c1ccncc1)c1ccc[nH]1)C(=O)N2 CHEMBL232177 IC50 10.0 nM
C[C@H]1CC[C@@H](NC(=O)OC(C)(C)C)CN1c1cc(-c2ccc3c(N)[nH]nc3c2)nc(N)n1 CHEMBL1614776 pIC50 10.0 nM
Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1990583 pKi 10.0 nM
CNc1ncnc2ccc(C#CCNC(=O)c3cc(Cl)nn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640495 IC50 10.0 nM
CN1CCC[C@@H](n2cnc3cnc4ccc(C#CCNC(=O)c5cncn(Cc6ccc(F)c(F)c6)c5=O)cc4c32)C1 CHEMBL3644688 IC50 10.0 nM
Cc1c(C#CCNC(=O)c2cncn(Cc3ccc(F)c(F)c3)c2=O)ccc2ncc(NCCCN(C)C)nc12 CHEMBL3640542 IC50 11.0 nM
NC1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3n2)C1 CHEMBL3689214 IC50 11.0 nM
CCOc1ccnc2ccc(C#CCNC(=O)c3cccn(C(CO)c4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3639881 IC50 11.0 nM
O=C(NCC#Cc1ccc2nccc(OCC3CCOCC3)c2c1)c1cccn(C(CO)c2ccc(F)c(F)c2)c1=O CHEMBL3689309 IC50 11.0 nM
COCC(O)CN(c1ccccc1)c1cc(-c2c[nH]c3ncc(-c4cnn(C)c4)cc23)nc(N)n1 CHEMBL3652578 IC50 11.0 nM
CC(C)N1CCC(n2cnc3cnc4ccc(C#CCNC(=O)c5cncn(Cc6ccc(F)c(F)c6)c5=O)cc4c32)CC1 CHEMBL3644690 IC50 11.0 nM
CN1CC[C@H](n2cnc3cnc4ccc(C#CCNC(=O)c5cc(Cl)nn(Cc6ccc(F)c(F)c6)c5=O)cc4c32)C1 CHEMBL3644743 IC50 11.0 nM
CN(C)CCCOc1ccnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689262 IC50 12.0 nM
O=C(NCC#Cc1ccc2nccc(OCC3CCOC3)c2c1)c1cccn(C(CO)c2ccc(F)c(F)c2)c1=O CHEMBL3689298 IC50 12.0 nM
CNc1ncnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640438 IC50 12.0 nM
CN1CCC(NC(=O)c2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c2)CC1 CHEMBL3640508 IC50 12.0 nM
CCN(c1ccccc1)c1cc(-c2c[nH]c3ncc(-c4cnn(C)c4)cc23)nc(N)n1 CHEMBL3652569 IC50 12.0 nM
Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCC#N)c4c21)CNC3=O CHEMBL302449 pKi 12.59 nM
COc1cc2ncc3c(N)nc(-c4cncc(OC[C@@H](N)Cc5cccc(C(F)(F)F)c5)c4)cc3c2cc1OC CHEMBL1098302 IC50 13.0 nM
CCc1cc(-c2c[nH]c3ncc(-c4cn[nH]c4)cc23)nc(N)n1 CHEMBL3813865 IC50 13.0 nM
CN(C)CC(C)(C)COc1ccnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689271 IC50 13.0 nM
CN(c1ncnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12)C1CC1 CHEMBL3640457 IC50 13.0 nM
Cn1cc(-c2cnc3[nH]cc(-c4cc(N(CCO)c5ccccc5)nc(N)n4)c3c2)cn1 CHEMBL3652561 IC50 13.0 nM
CCN1CCC(n2c(C)nc3cnc4ccc(C#CCNC(=O)c5cc(C)nn(Cc6ccc(F)c(F)c6)c5=O)cc4c32)CC1 CHEMBL3644725 IC50 13.0 nM
CC/C(=C1/C(=O)Nc2ccc(S(N)(=O)=O)cc21)c1ccc[nH]1 CHEMBL234811 IC50 14.0 nM
COc1cc2ncc3c(N)nc(-c4cncc(OC[C@@H](N)CC(C)C)c4)cc3c2cc1OC CHEMBL1094321 IC50 14.0 nM
CN1CCN(CCCOc2ccnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc23)CC1 CHEMBL3689269 IC50 14.0 nM
CNc1ncnc2ccc(C#CCNC(=O)c3cccn([C@H](CO)c4ccccc4)c3=O)cc12 CHEMBL3640500 IC50 14.0 nM
O=C(NCC#Cc1ccc2nccc(C3=CCCNC3)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3640524 IC50 14.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn(CC5CCCCC5)c4=O)cc3c2n1C(C)C CHEMBL3644711 IC50 14.0 nM
Cn1c(CCO)nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c21 CHEMBL3647293 IC50 14.0 nM
COc1cc2ncc3c(N)nc(-c4cncc(OC[C@H](N)Cc5ccc(F)cc5)c4)cc3c2cc1OC CHEMBL1095622 IC50 15.0 nM
COc1cc2ncc3c(N)nc(-c4cncc(OC[C@H](N)Cc5c[nH]c6ccccc56)c4)cc3c2cc1OC CHEMBL1097604 IC50 15.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL1240703 Kd 15.0 nM
CN(C)CCCOc1ccnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689257 IC50 15.0 nM
O=C(NCC#Cc1ccc2nccc(OC3CCNCC3)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689282 IC50 15.0 nM
CN(c1ccccc1)c1ncnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640485 IC50 15.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn(CC5C[C@@H]6CC[C@H]5C6)c4=O)cc3c2n1C(C)C CHEMBL3644715 IC50 15.0 nM
Cc1cc(C(=O)NCC#Cc2ccc3ncc4ncn([C@H]5CC[C@@H](N(C)C)CC5)c4c3c2)c(=O)n(Cc2ccc(F)c(F)c2)n1 CHEMBL3644730 IC50 15.0 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 15.85 nM
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1973540 pKi 15.85 nM
CN(C)CCCOc1ccnc2ccc(C#CCNC(=O)c3ccnn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689299 IC50 16.0 nM
CN(Cc1ccccc1)c1ncnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640442 IC50 16.0 nM
CON(C)c1ncnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640499 IC50 16.0 nM
CN(C)CCCn1cnc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c21 CHEMBL3644687 IC50 16.0 nM
O=C(NCC#Cc1ccc2ncc3ncn(C4CCNC4)c3c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3644692 IC50 16.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn([C@@H](CN)c5ccccc5)c4=O)cc3c2n1C(C)C CHEMBL3644714 IC50 16.0 nM
CN(c1ccccc1)c1cc(-c2c[nH]c3ncc(-c4cnn(C)c4)cc23)nc(N)n1 CHEMBL3652568 IC50 16.5 nM
COc1cc2ncc3c(N)nc(-c4cncc(OC[C@H](N)Cc5ccccc5)c4)cc3c2cc1OC CHEMBL1095294 IC50 17.0 nM
CN(C)CCSc1cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc2n1 CHEMBL3689190 IC50 17.0 nM
C[C@@H](c1cc(F)c(F)c(F)c1)n1cccc(C(=O)NCC#Cc2ccc3nccc(OC[C@@H]4CCCN(CCN5CCOCC5)C4)c3c2)c1=O CHEMBL3689313 IC50 17.0 nM
CC(C)n1cc(-c2cnc3[nH]cc(-c4cc(N(CCO)c5ccccc5Cl)nc(N)n4)c3c2)cn1 CHEMBL3652572 IC50 17.0 nM
Cn1cc(-c2cnc3[nH]cc(-c4cc(N(CCC(N)=O)c5ccccc5)nc(N)n4)c3c2)cn1 CHEMBL3652589 IC50 17.0 nM
NC(=O)Nc1ccc2c(c1)/C(=C/c1ccc[nH]1)C(=O)N2 CHEMBL442229 IC50 18.0 nM
COc1cc2ncc3c(N)nc(-c4cncc(OC[C@H](N)CC(C)C)c4)cc3c2cc1OC CHEMBL1094637 IC50 18.0 nM
CN1CC[C@H](n2cnc3cnc4ccc(C#CCNC(=O)c5cncn(Cc6ccc(F)c(F)c6)c5=O)cc4c32)C1 CHEMBL3644686 IC50 18.0 nM
O=C(NCC#Cc1ccc2ncc3ncn(C4CCNC4)c3c2c1)c1cccn([C@H](CO)c2ccccc2)c1=O CHEMBL3644728 IC50 18.0 nM
O=C(NCC#Cc1ccc2ncc3ncn(CCO)c3c2c1)c1cccn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3644738 IC50 18.0 nM
COc1nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c2n1C CHEMBL3647296 IC50 18.0 nM
O=C(NCC#Cc1ccc2nccc(-c3cc[nH]c3)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3640521 IC50 19.0 nM
Cn1c(CF)nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c21 CHEMBL3647291 IC50 19.0 nM
Nc1nc(-c2ccc3c(N)[nH]nc3c2)cc(N2CCO[C@H](C(=O)Nc3ccccc3)C2)n1 CHEMBL1614774 pIC50 19.95 nM
Nc1nc(Nc2ccccc2)cc(-c2ccc3c(N)n[nH]c3c2)n1 CHEMBL1765876 pIC50 19.95 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL244378 pKi 19.95 nM
NCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL590109 pKi 19.95 nM
NC(=O)Nc1ccc2c(c1)/C(=C/c1cc(-c3cccc(O)c3)c[nH]1)C(=O)N2 CHEMBL228439 IC50 20.0 nM
CN(C)CCCNC(=O)c1cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc2c1 CHEMBL3640504 IC50 20.0 nM
CN1CC(NC(=O)c2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c2)C1 CHEMBL3640514 IC50 20.0 nM
CN1CC[C@@H](n2cnc3cnc4ccc(C#CCNC(=O)c5cccn(Cc6ccc(F)c(F)c6)c5=O)cc4c32)C1 CHEMBL3644742 IC50 20.0 nM
Cn1cc(-c2cnc3[nH]cc(-c4cc(C5(c6ccccc6F)CC5)nc(N)n4)c3c2)cn1 CHEMBL3652590 IC50 20.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 20.0 nM
COc1cc2ncc3c(N)nc(-c4cncc(OC[C@H](N)Cc5cccc(C(F)(F)F)c5)c4)cc3c2cc1OC CHEMBL1095285 IC50 21.0 nM
CNC(=O)c1cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc2n1 CHEMBL4113701 IC50 21.0 nM
CN1CCC(N(C)c2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3n2)CC1 CHEMBL3689199 IC50 21.0 nM
CC(C)Nc1cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc2n1 CHEMBL3689206 IC50 21.0 nM
O=C(NCC#Cc1ccc2ncc(N[C@H]3CC[C@H](O)CC3)nc2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3639880 IC50 21.0 nM
CNC(=O)c1cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)c(C)c2c1 CHEMBL3689253 IC50 21.0 nM
CC(=O)N[C@@H]1CCN(c2ncnc3ccc(C#CCNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)cc23)C1 CHEMBL3640467 IC50 21.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4ccnn(Cc5ccc(F)c(F)c5)c4=O)cc3c2n1C1CCN(C(C)C)CC1 CHEMBL3644731 IC50 21.0 nM
CC(=O)NCCCN(c1ccccc1)c1cc(-c2c[nH]c3ncc(-c4cnn(C)c4)cc23)nc(N)n1 CHEMBL3652591 IC50 22.0 nM
CN(C)CCc1nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c2n1C CHEMBL3647299 IC50 22.0 nM
O=C(NCC#Cc1ccc2ncc(OC3CCNCC3)cc2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689256 IC50 23.0 nM
CN(C)CCCN(C)c1ccnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689258 IC50 23.0 nM
O=C(NCC#Cc1ccc2nccc(OC3CCNCC3)c2c1)c1cccn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689283 IC50 23.0 nM
COc1cc2ncc3c(N)nc(-c4cncc(Nc5ccccc5CCO)c4)cc3c2cc1OC CHEMBL585339 IC50 24.0 nM
CN1CCC(NC(=O)c2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c2)C1 CHEMBL3640520 IC50 24.0 nM
Cc1n[nH]cc1-c1ccnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640526 IC50 24.0 nM
COc1ccc(N(C[C@H](O)CO)c2cc(-c3c[nH]c4ncc(-c5cnn(C)c5)cc34)nc(N)n2)cc1 CHEMBL3652562 IC50 24.0 nM
COCCc1nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c2n1C CHEMBL3647290 IC50 24.0 nM
CN(C)CCOc1ccnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689267 IC50 25.0 nM
CC(C)(C)OC(=O)N[C@@H]1CCCN(c2cc(-c3ccc4c(N)n[nH]c4c3)nc(N)n2)C1 CHEMBL1765748 pIC50 25.12 nM
COc1cc2ncc3c(N)nc(-c4cncc(N)c4)cc3c2cc1OC CHEMBL572235 IC50 26.0 nM
O=C(NCC#Cc1ccc2nccc(OCC3CCOCC3)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689300 IC50 26.0 nM
CN(C)c1ncnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640441 IC50 26.0 nM
CN1CC[C@@H](n2cnc3cnc4ccc(C#CCNC(=O)c5cncn(Cc6ccc(F)c(F)c6)c5=O)cc4c32)C1 CHEMBL3644685 IC50 26.0 nM
O=P(O)(O)O[C@@H]1[C@@H](OP(=O)(O)O)[C@@H](OP(=O)(O)O)[C@@H](OCc2ccccc2)[C@H](OP(=O)(O)O)[C@H]1OP(=O)(O)O CHEMBL2332032 IC50 26.5 nM
O=P(O)(O)OC[C@@H]1[C@@H](OP(=O)(O)O)[C@H](OP(=O)(O)O)[C@@H](OP(=O)(O)O)[C@H](OP(=O)(O)O)[C@@H]1OCc1ccccc1 CHEMBL3823242 IC50 26.5 nM
CNc1cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc2n1 CHEMBL3689186 IC50 27.0 nM
CN(C)c1c(C#N)cnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640527 IC50 27.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn(CC5CCCC5)c4=O)cc3c2n1C(C)C CHEMBL3644718 IC50 27.0 nM
O=C(NCC#Cc1ccc2ncc3ncn([C@H]4CCNC4)c3c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3644694 IC50 28.0 nM
NS(=O)(=O)c1ccc2c(c1)/C(=C(\c1ccccc1)c1ccc[nH]1)C(=O)N2 CHEMBL267837 IC50 29.0 nM
CN1CCC(Oc2ccnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc23)CC1 CHEMBL3689280 IC50 29.0 nM
COc1cc2ncc3c(N)nc(-c4cncc(Nc5ccccc5F)c4)cc3c2cc1OC CHEMBL571168 IC50 30.0 nM
CC(C)(C(N)=O)C(=O)NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1Br CHEMBL573108 IC50 30.0 nM
CC(C)n1cc(-c2cnc3[nH]cc(-c4cc(N(C)c5ccccc5Cl)nc(N)n4)c3c2)cn1 CHEMBL3652576 IC50 30.0 nM
O=C(NC1CC1)c1cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc2c1 CHEMBL3640507 IC50 31.0 nM
CCNC(=O)c1cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc2c1 CHEMBL3640509 IC50 31.0 nM
CC[C@@H]1COCCN1c1cc(-c2ccc3c(N)n[nH]c3c2)nc(N)n1 CHEMBL1765728 pIC50 31.62 nM
Nc1nc(-c2ccc3c(N)n[nH]c3c2)cc(N2CCC[C@H](C(=O)Nc3ccccc3)C2)n1 CHEMBL1765732 pIC50 31.62 nM
CC(N)CCOc1ccnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689301 IC50 32.0 nM
CCN1CCC(n2cnc3cnc4ccc(C#CCNC(=O)c5c(C)n(C)n(Cc6ccc(F)c(F)c6)c5=O)cc4c32)CC1 CHEMBL3644747 IC50 32.0 nM
CN1CCC(Nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3n2)C1 CHEMBL3689188 IC50 33.0 nM
CCOc1ccnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689264 IC50 33.0 nM
CN(C)CC(C)(C)COc1ccnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689272 IC50 33.0 nM
CCOc1nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c2n1C CHEMBL3644762 IC50 33.0 nM
CCOC(=O)/C(=C1/C(=O)Nc2ccc(S(N)(=O)=O)cc21)c1ccc[nH]1 CHEMBL400837 IC50 34.0 nM
N#CCc1ccc(-n2cnc3cnc4ccc(C#Cc5cccnc5)cc4c32)cc1 CHEMBL272265 IC50 34.0 nM
CN(C)CCCN(C)c1cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc2n1 CHEMBL3689185 IC50 34.0 nM
CN(c1cccc(F)c1)c1cc(-c2c[nH]c3ncc(-c4cnn(C)c4)cc23)nc(N)n1 CHEMBL3652558 IC50 34.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn([C@@H](C)C5CCCCC5)c4=O)cc3c2n1C(C)C CHEMBL3644707 IC50 34.0 nM
COc1cc2ncc3c(N)nc(-c4cccnc4)cc3c2cc1OC CHEMBL572234 IC50 35.0 nM
CC(C)n1cc(C(=O)c2cncc(NCCc3cccnc3)n2)c2c(N)ncnc21 CHEMBL1940244 Ki 35.0 nM
CN(C)CCNc1cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc2n1 CHEMBL3689184 IC50 35.0 nM
O=C(NCC#Cc1ccc2nccc(-c3cn[nH]c3)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3640522 IC50 35.0 nM
NCCCn1nc(C(N)=O)c2c1-c1nc(Nc3ccccc3)ncc1CC2 CHEMBL1171950 IC50 36.0 nM
CN(C)CCOc1ccnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689268 IC50 36.0 nM
COc1ncnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640543 IC50 37.0 nM
COc1ccnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689260 IC50 38.0 nM
CC(C)Oc1ccnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689266 IC50 38.0 nM
Cc1cccc(Nc2nc(NC3CCCCC3N)cnc2C(N)=O)c1 CHEMBL1974328 pKi 39.81 nM
COc1cc2ncc3c(N)nc4c(C)c(O)ccc4c3c2cc1OC CHEMBL391550 IC50 40.0 nM
N[C@H]1CC[C@@H](Nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3n2)CC1 CHEMBL3689204 IC50 40.0 nM
CN(Cc1cnn(-c2ccc(F)cc2)c1)c1ncnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640481 IC50 40.0 nM
O=C(NCC#Cc1ccc2ncc(NC3CC(N4CCCC4)C3)nc2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689200 IC50 41.0 nM
COc1ccc(CCNc2ncnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc23)cc1 CHEMBL3640455 IC50 41.0 nM
COCc1nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c2n1C CHEMBL3647297 IC50 41.0 nM
CN(C)CC(C)(C)CNc1cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc2n1 CHEMBL3689196 IC50 42.0 nM
COCCOc1cc2ncc3c(N)nc(-c4cccnc4)cc3c2cc1OC CHEMBL583247 IC50 43.0 nM
CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CS)C(=O)O CHEMBL1213203 Kd 43.0 nM
O=C(NCC#Cc1ccc2ncnc(NCC(O)CO)c2c1)c1cccn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3640474 IC50 44.0 nM
NC(=O)c1cc(-c2ccsc2)cc2c(N[C@H]3CCCNC3)ncnc12 CHEMBL3685311 IC50 44.0 nM
CNC(=O)c1cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc2c1 CHEMBL3640506 IC50 45.0 nM
Cc1c(C(=O)NCC#Cc2ccc3ncc4ncn(C5CCN(C(C)C)CC5)c4c3c2)c(=O)n(Cc2ccc(F)c(F)c2)n1C CHEMBL3644746 IC50 45.0 nM
COc1ccc(-c2nc(Nc3cccc(NC(=O)NC4CCNC4)c3)nc3[nH]cnc23)cc1 CHEMBL2023413 IC50 46.0 nM
O=C(NCC#Cc1ccc2nccc(OCC3CCCOC3)c2c1)c1cccn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689302 IC50 46.0 nM
CNc1c(C#N)cnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640538 IC50 46.0 nM
CCN(c1ccc(Cl)cc1)c1cc(-c2c[nH]c3ncc(-c4cnn(C)c4)cc23)nc(N)n1 CHEMBL3652570 IC50 46.0 nM
COc1cc2ncc3c(N)nc(-c4cncc(Nc5ccccc5CO)c4)cc3c2cc1OC CHEMBL572219 IC50 47.0 nM
CN(C)CC(O)COc1ccnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689274 IC50 47.0 nM
CCN(CC)c1ncnc2ccc(C#CCNC(=O)c3c(C)n(CCO)n(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640486 IC50 50.0 nM
CN(C)CCn1cnc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c21 CHEMBL3644684 IC50 50.0 nM
CC(C)(C)OC(=O)NC1CCCN(c2cc(-c3ccc4c(N)n[nH]c4c3)nc(N)n2)C1 CHEMBL1765746 pIC50 50.12 nM
Nc1nc(NC2CCCC2)cc(-c2ccc3c(N)n[nH]c3c2)n1 CHEMBL1765762 pIC50 50.12 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 50.12 nM
OC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1991674 pKi 50.12 nM
O=C(NCC1CCCCC1)c1cc2c(-c3ccccc3)n[nH]c2s1 CHEMBL2005475 pKi 50.12 nM
Cc1cccc(Nc2nccc(Nc3c(NC(C)C(C)(C)C)c(=O)c3=O)n2)c1 CHEMBL1969523 pKi 50.12 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 50.12 nM
COc1cc2c(cc1F)C(c1ccccc1Cl)=Nc1c(n[nH]c1C)N2 CHEMBL1980391 pKi 50.12 nM
COc1cc2ncc3c(N)nc(-c4cncc(Nc5ccccc5N)c4)cc3c2cc1OC CHEMBL585345 IC50 51.0 nM
CN(c1cccc(Cl)c1)c1cc(-c2c[nH]c3ncc(-c4cnn(C)c4)cc23)nc(N)n1 CHEMBL3652565 IC50 51.0 nM
CCN(Cc1ccccc1)c1cc(-c2c[nH]c3ncc(-c4cnn(C)c4)cc23)nc(N)n1 CHEMBL3652571 IC50 51.0 nM
O=C(NCC#Cc1ccc2ncnc(N3CCCC3)c2c1)c1cccn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3640464 IC50 52.0 nM
CC(C)NC(=O)c1cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc2c1 CHEMBL3640510 IC50 53.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c2n1CCN(C)C CHEMBL3644740 IC50 53.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1 CHEMBL4550702 IC50 53.0 nM
CC(C)n1cc(-c2cnc3[nH]cc(-c4cc(C(C)(O)c5ccccc5)nc(N)n4)c3c2)cn1 CHEMBL3969929 IC50 54.0 nM
CC(=O)Nc1ccc2c(c1)/C(=C/c1ccc[nH]1)C(=O)N2 CHEMBL393902 IC50 55.0 nM
CCOc1ccnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689263 IC50 55.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn([C@H](C)c5ccc(F)c(F)c5)c4=O)cc3c2n1C(C)C CHEMBL3644701 IC50 55.0 nM
CN1CCC(Oc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3n2)CC1 CHEMBL3689209 IC50 56.0 nM
Cc1ccnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640525 IC50 56.0 nM
COc1cc2ncc3c(N)nc(-c4cncc(O)c4)cc3c2cc1OC CHEMBL571806 IC50 57.0 nM
CONc1ncnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640498 IC50 57.0 nM
O=C(NCC#Cc1ccc2ncnc(-c3cn[nH]c3)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3640501 IC50 57.0 nM
CCc1cc(-c2c[nH]c3ncc(-c4cnn(C5CCNCC5)c4)cc23)nc(N)n1 CHEMBL3814140 IC50 58.0 nM
O=C(NCC#Cc1ccc2ncnc(-c3ccccc3)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3639393 IC50 58.0 nM
CN(CCCO)c1ncnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640471 IC50 59.0 nM
NC(=O)CNc1ncnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640472 IC50 59.0 nM
Cn1cc(-c2cnc3[nH]cc(-c4cc(C5(c6ccccc6)CC5)nc(N)n4)c3c2)cn1 CHEMBL3652560 IC50 59.5 nM
COc1cc2ncc3c(N)nc4c(C)c(N)ccc4c3c2cc1OC CHEMBL235157 IC50 60.0 nM
COc1cc2c(cc1OCCN1CCOCC1)ncc1c(N)nc3c(C)c(N)ccc3c12 CHEMBL238337 IC50 60.0 nM
CC(C)(C)COc1ccnc2ccc(C#CCNC(=O)c3cccn(C(CO)c4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689308 IC50 60.0 nM
CCN(CC)c1ncnc2ccc(C#CCNC(=O)c3cccn([C@@H](C)c4ccccc4)c3=O)cc12 CHEMBL3640492 IC50 60.0 nM
NC(=O)C1=c2ncnc(N[C@H]3CCCNC3)c2=CC(c2cccs2)C1 CHEMBL3923286 IC50 60.0 nM
CC1(O)CCN(c2ncnc3ccc(C#CCNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)cc23)CC1 CHEMBL3640478 IC50 61.0 nM
Cc1c(C#CCNC(=O)c2cncn(Cc3ccc(F)c(F)c3)c2=O)ccc2ncc(C(=O)O)cc12 CHEMBL3689252 IC50 62.0 nM
COc1ccc(-c2cc(C(N)=O)c3ncnc(N[C@H]4CCCNC4)c3c2)cc1 CHEMBL3685312 IC50 62.0 nM
COc1cccc(CN(C)c2ncnc3ccc(C#CCNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)cc23)c1 CHEMBL3640482 IC50 63.0 nM
C[C@@H]1COCCN1c1cc(-c2ccc3c(N)[nH]nc3c2)nc(N)n1 CHEMBL1614773 pIC50 63.1 nM
Nc1nc(-c2ccc3c(N)n[nH]c3c2)cc(N2CCC[C@H](C(=O)NC3CCCCC3)C2)n1 CHEMBL1765734 pIC50 63.1 nM
Nc1nc(-c2ccc3c(N)n[nH]c3c2)cc(N2CCCC(NC(=O)c3ccccc3)C2)n1 CHEMBL1765745 pIC50 63.1 nM
CN1CCCC(NC(=O)c2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c2)C1 CHEMBL3640513 IC50 64.0 nM
COc1cc2ncc3c(N)nc(-c4cncc(Br)c4)cc3c2cc1OC CHEMBL570148 IC50 65.0 nM
Cn1cc(-c2cnc3[nH]cc(-c4cc(C(C)(C)c5ccccc5)nc(N)n4)c3c2)cn1 CHEMBL3652559 IC50 65.0 nM
COc1cc2ncc3c(N)nc(-c4cncn4C)cc3c2cc1OC CHEMBL569905 IC50 66.0 nM
O=C(NCC#Cc1ccc2ncc(-c3ccccc3)cc2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689250 IC50 66.0 nM
C/C(=C1/C(=O)Nc2ccc(S(N)(=O)=O)cc21)c1ccc[nH]1 CHEMBL234601 IC50 67.0 nM
COc1cc2ncc3c(N)nc(-c4cncc(Nc5cccc(CO)c5)c4)cc3c2cc1OC CHEMBL570702 IC50 67.0 nM
O=C(NCCCNc1nc(Nc2cccc(F)c2)ncc1Br)C1CCC1 CHEMBL2207181 IC50 68.0 nM
CNc1ncnc2ccc(C#CCNC(=O)c3c(C)n(C)n(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640544 IC50 68.0 nM
CN(C)c1cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc2n1 CHEMBL3689187 IC50 68.0 nM
O=C(NCC#Cc1ccc2ncc3ncn(CCO)c3c2c1)c1cccn(Cc2ccccc2)c1=O CHEMBL3644739 IC50 68.0 nM
COC(=O)CN(c1ccc(Cl)cc1)c1cc(-c2c[nH]c3ncc(-c4cnn(C)c4)cc23)nc(N)n1 CHEMBL3652580 IC50 69.0 nM
CCC(=O)CN(c1ccc(Cl)cc1)c1cc(-c2c[nH]c3ncc(-c4cnn(C)c4)cc23)nc(N)n1 CHEMBL3976393 IC50 69.0 nM
COCCOc1cc2ncc3c(N)nc(-n4ccnc4)cc3c2cc1OC CHEMBL571159 IC50 70.0 nM
Cc1cc(C(=O)NCC#Cc2ccc3ncc4nc(C)n(C(C)C)c4c3c2)c(=O)n([C@@H](C)c2ccc(F)c(F)c2)n1 CHEMBL3644705 IC50 70.0 nM
CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(-c4ccncc4)cc3)n2)c(=O)c1=O CHEMBL2205426 Ki 71.0 nM
CN(C)CC(O)COc1ccnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689273 IC50 71.0 nM
CN1CCC(Oc2ccnc3ccc(C#CCNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)cc23)CC1 CHEMBL3689281 IC50 71.0 nM
Cn1c(-c2ccccc2)nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c21 CHEMBL3647294 IC50 72.0 nM
CCOc1cc2ncc3c(N)nc(-c4cccnc4)cc3c2cc1OCC CHEMBL570943 IC50 74.0 nM
COc1ccccc1Nc1cncc(-c2cc3c(cnc4cc(OC)c(OC)cc43)c(N)n2)c1 CHEMBL570281 IC50 74.0 nM
CC(C)Oc1ccnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689265 IC50 74.0 nM
CN(C)C1CCN(c2ncnc3ccc(C#CCNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)cc23)CC1 CHEMBL3640477 IC50 74.0 nM
COc1ccc(-c2nc(Nc3cccc(NC(=O)NCCN4CCOCC4)c3)nc3[nH]cnc23)cc1 CHEMBL2023415 IC50 75.0 nM
O=C(Nc1ccc2[nH]nc(-c3nc4ccc(N5CCOCC5)cc4[nH]3)c2c1)C1CC1(F)F CHEMBL3659990 EC50 75.6 nM
CC1CN(c2ccc3nc(-c4n[nH]c5ccc(NC(=O)C6CC6(F)F)cc45)[nH]c3c2)CCO1 CHEMBL3659991 EC50 76.7 nM
O=C(NCC#Cc1ccc2ncnc(NC3CCN(CCO)CC3)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3640461 IC50 77.0 nM
CCN(C)c1c(C#N)cnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640536 IC50 77.0 nM
COc1ccc(-c2nc(Nc3cccc(NC(=O)C4CCNCC4)c3)nc3[nH]cnc23)cc1OC CHEMBL2023418 IC50 79.0 nM
NC(=O)CCNc1ncnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640470 IC50 79.0 nM
CN(C)Cc1nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c2n1C CHEMBL3647292 IC50 79.0 nM
CNc1cc(-c2ccc3c(N)n[nH]c3c2)nc(N)n1 CHEMBL1765760 pIC50 79.43 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 79.43 nM
O=C1NCCc2[nH]c(-c3ccnc(C=Cc4ccccc4)c3)cc21 CHEMBL1997129 pKi 79.43 nM
COc1ccc(Nc2nccc(Nc3c(NC(C)C(C)(C)C)c(=O)c3=O)n2)cc1OC CHEMBL1964399 pKi 79.43 nM
CS(=O)(=O)N(Cc1ccc2[nH]c(=O)c3cccn3c2c1)C1CC1 CHEMBL1978448 pKi 79.43 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 79.43 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 79.43 nM
Clc1cc(NC2CCCCC2)nc(-c2c[nH]c3ncccc23)n1 CHEMBL1997846 pKi 79.43 nM
C/C(=C1/C(=O)Nc2ccc(O)cc21)c1ccc[nH]1 CHEMBL231717 IC50 80.0 nM
Cc1c(C#CCNC(=O)c2cncn(Cc3ccc(F)c(F)c3)c2=O)ccc2ncc(-c3ccccc3)cc12 CHEMBL3689248 IC50 80.0 nM
CCc1cc(-c2c[nH]c3ncc(-c4cnn(CCN(C)C)c4)cc23)nc(N)n1 CHEMBL3814770 IC50 82.0 nM
COc1ccc(-c2nc(Nc3cccc(NC(=O)NCCN4CCOCC4)c3)nc3[nH]cnc23)cc1OC CHEMBL2023414 IC50 84.0 nM
CCCCc1cc(-c2c[nH]c3ncc(-c4cnn(C5CCNCC5)c4)cc23)nc(N)n1 CHEMBL3815046 IC50 84.0 nM
Cc1cc(CNC(=O)c2nn(CCCN)c3c2CCc2cnc(Nc4cccc(CC(=O)N(C)C)c4)nc2-3)ccn1 CHEMBL1172241 IC50 85.0 nM
CCc1cc(-c2c[nH]c3ncc(-c4cnn(C)c4)cc23)nc(N)n1 CHEMBL3814785 IC50 85.0 nM
O=C(NCC#Cc1ccc2ncc(O)cc2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689255 IC50 86.0 nM
CCNc1c([N+](=O)[O-])cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640435 IC50 86.0 nM
O=C(NCC#Cc1ccc2nccc(C3=CCNCC3)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3640523 IC50 86.0 nM
CN1CCN(Nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3n2)CC1 CHEMBL3689207 IC50 87.0 nM
CN(C)CCN(C)c1cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc2n1 CHEMBL3640545 IC50 88.0 nM
Cn1cc(-c2cnc3[nH]cc(-c4cc(N(CCN5CCOCC5)c5cccc(F)c5)nc(N)n4)c3c2)cn1 CHEMBL3652584 IC50 89.0 nM
Cn1cc(-c2cnc3[nH]cc(-c4cc(N(CC(O)CO)c5cccc(C#N)c5)nc(N)n4)c3c2)cn1 CHEMBL3652579 IC50 90.0 nM
COc1cc2ncc3c(N)nc(-c4cncc(Nc5ccc(CCO)cc5)c4)cc3c2cc1OC CHEMBL571166 IC50 91.0 nM
COc1ccc(CCNc2ncnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc23)cc1OC CHEMBL3640445 IC50 91.0 nM
CCOc1ncnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3922103 IC50 94.0 nM
Cn1cc(-c2cc(C(N)=O)c3ncnc(N[C@H]4CCCNC4)c3c2)cn1 CHEMBL3685313 IC50 94.0 nM
CN(C)CCCOc1cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc2n1 CHEMBL3689189 IC50 95.0 nM
O=C(NCC#Cc1ccc2ncnc(C3=CCNCC3)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3640503 IC50 96.0 nM
CN1CCC(CNc2ncnc3ccc(C#CCNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)cc23)C1 CHEMBL3640475 IC50 97.0 nM
COc1ccc(-c2nc(Nc3cccc(NC(=O)CN)c3)nc3[nH]cnc23)cc1OC CHEMBL1933346 IC50 98.0 nM
CNc1c([N+](=O)[O-])cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640436 IC50 98.0 nM
O=C(NCC#Cc1ccc2ncnc(NCCc3ccco3)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3640443 IC50 98.0 nM
Cc1ncnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640502 IC50 98.0 nM
COc1ccc2cc(-c3cc(C(N)=O)c4ncnc(N[C@H]5CCCNC5)c4c3)ccc2c1 CHEMBL3685314 IC50 98.0 nM
CN(C)CCNC(=O)c1cccc(-c2c[nH]c(/C=C3\C(=O)Nc4ccc(NC(N)=O)cc43)c2)c1 CHEMBL228804 IC50 100.0 nM
NC(=O)Nc1ccc2c(c1)/C(=C/c1cc(-c3cccnc3)c[nH]1)C(=O)N2 CHEMBL375236 IC50 100.0 nM
COc1cc2ncc3c(N)nc(-n4ccnc4)cc3c2cc1OC CHEMBL576905 IC50 100.0 nM
CNc1cncc(C(=O)c2cn(C(C)C)c3ncnc(N)c23)n1 CHEMBL1940243 Ki 100.0 nM
O=C1Nc2cc(CCOc3ccc(N4CCOCC4)cc3)ccc2Nc2cc(-c3cn(Cc4cc(F)c(F)c(F)c4)c4cnccc34)ccc21 CHEMBL2001923 pKi 100.0 nM
Nc1ncnc2scc(C(=O)Nc3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL1988594 pKi 100.0 nM
COc1cc(Nc2ncc3c(n2)-c2ccc(Cl)cc2C(c2c(F)cccc2OC)=NC3)ccc1C(=O)O CHEMBL483158 pKi 100.0 nM
NC(=O)c1cc(-c2ccc(OC(F)(F)F)cc2)cc2c(N[C@H]3CCCNC3)ncnc12 CHEMBL3685315 IC50 100.0 nM
CN(C)CCCOc1ncnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640546 IC50 103.0 nM
O=C(NCC#Cc1ccc2ncnc(NCCc3ccccn3)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3640444 IC50 105.0 nM
COCCOc1cc2ncc3c(N)nc(-n4cnc(C)c4)cc3c2cc1OC CHEMBL585344 IC50 108.0 nM
Cc1nc2cnc3ccc(C#Cc4cccnc4)cc3c2n1-c1ccc(CC#N)cc1 CHEMBL270639 IC50 110.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 110.0 nM
COc1ccc(-c2nc(Nc3cccc(NC(=O)NC4CCNC4)c3)nc3[nH]cnc23)cc1OC CHEMBL2023201 IC50 110.0 nM
CCc1cc(-c2c[nH]c3ncc(-c4cnn(CC(C)C)c4)cc23)nc(N)n1 CHEMBL3813933 IC50 110.0 nM
CN(C)c1ccnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689259 IC50 110.0 nM
CNCCCN(C)c1ncnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640465 IC50 110.0 nM
NC(=O)c1cc(-c2ccc(C(F)(F)F)cc2)cc2c(N[C@H]3CCCNC3)ncnc12 CHEMBL3685316 IC50 110.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cc(Cl)nn(Cc5ccc(F)c(F)c5)c4=O)cc3c2n1[C@H]1CCCN(C)C1 CHEMBL3644744 IC50 111.0 nM
O=C(CNC(=O)c1cccn(Cc2ccc(F)c(F)c2)c1=O)Nc1ccc2c(c1)/C(=C/c1cnc[nH]1)C(=O)N2 CHEMBL3824119 IC50 112.0 nM
O=C(NCC#Cc1ccc2ncnc(N3CC[C@H](O)C3)c2c1)c1cccn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3640468 IC50 114.0 nM
O=C(NCC#Cc1ccc2nccc(OCC3CCCCO3)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689277 IC50 116.0 nM
CC(C)Nc1c([N+](=O)[O-])cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640437 IC50 116.0 nM
CN1CCN(c2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3n2)CC1 CHEMBL3689195 IC50 117.0 nM
CCN1CCC(CN(C)c2ncnc3ccc(C#CCNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)cc23)C1 CHEMBL3640484 IC50 117.0 nM
COC(=O)c1cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)c(C)c2c1 CHEMBL3689251 IC50 119.0 nM
CN1CCC(Oc2ccnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc23)C1 CHEMBL3689275 IC50 119.0 nM
NC(=O)c1ccc2c(c1)/C(=C/c1ccc[nH]1)C(=O)N2 CHEMBL395163 IC50 120.0 nM
CCc1cc(-c2c[nH]c3ncc(-c4ccco4)cc23)nc(N)n1 CHEMBL3814317 IC50 120.0 nM
CC(C)(CO)CNc1ncnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640469 IC50 124.0 nM
C[C@@H]1CCCCN1c1cc(-c2ccc3c(N)n[nH]c3c2)nc(N)n1 CHEMBL1765730 pIC50 125.89 nM
Nc1nc(-c2ccc3c(N)n[nH]c3c2)cc(N2CCC[C@@H](C(=O)Nc3ccccc3)C2)n1 CHEMBL1765733 pIC50 125.89 nM
Nc1nc(-c2ccc3c(N)n[nH]c3c2)cc(N2CCC[C@H](C(=O)NC3CCCC3)C2)n1 CHEMBL1765735 pIC50 125.89 nM
Cc1cc(-c2ccc3c(N)n[nH]c3c2)nc(N)n1 CHEMBL1765756 pIC50 125.89 nM
CC(C)Nc1cc(-c2ccc3c(N)n[nH]c3c2)nc(N)n1 CHEMBL1765761 pIC50 125.89 nM
CCc1c(-c2ccc(C(C)(C)O)cc2)[nH]c2nccnc12 CHEMBL1976420 pKi 125.89 nM
O=C1Cc2c([nH]c3ccc([N+](=O)[O-])cc23)-c2ccccc2N1 CHEMBL50894 pKi 125.89 nM
CC1CN(C)CCC1Nc1ncnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640462 IC50 126.0 nM
COc1ccnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689261 IC50 128.0 nM
O=C(NCCCNc1nc(Nc2cccc(F)c2)ncc1Br)c1cccs1 CHEMBL2207218 IC50 130.0 nM
Cn1cc(-c2cnc3[nH]cc(-c4cc(C5(c6ccccc6)CCCC5)nc(N)n4)c3c2)cn1 CHEMBL3652563 IC50 130.0 nM
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 CHEMBL4569508 IC50 130.0 nM
O=C(NCC#Cc1ccc2ncccc2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689249 IC50 132.0 nM
CN(CCc1ccccc1)c1ncnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640440 IC50 134.0 nM
O=C(NCC#Cc1ccc2ncnc(NCCCn3ccnc3)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3640448 IC50 135.0 nM
COC(C)CCOc1ccnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689279 IC50 137.0 nM
CN1CCCC1CCNc1ncnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640476 IC50 137.0 nM
COc1cc2ncc3c(N)nc(-c4cncc(Nc5ccc(CO)cc5)c4)cc3c2cc1OC CHEMBL570284 IC50 142.0 nM
O=C(NCC#Cc1ccc2ncnc(NC3CCN(Cc4ccccc4)CC3)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3640460 IC50 142.0 nM
COc1cc2c(cc1OCCCN1CCCCC1)ncc1c(N)nc(-c3cccnc3)cc12 CHEMBL583455 IC50 144.0 nM
COc1cc2c(cc1OCc1ccccc1)ncc1c(N)nc(-c3cccnc3)cc12 CHEMBL585341 IC50 146.0 nM
CC(C)Nc1c(C#N)cnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640537 IC50 147.0 nM
CC(C)N(C)c1c(C#N)cnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640534 IC50 148.0 nM
CN1CCCC(Nc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3n2)C1 CHEMBL3689192 IC50 149.0 nM
CC(C#N)c1ccc(-n2cnc3cnc4ccc(C#Cc5cccnc5)cc4c32)cc1 CHEMBL404024 IC50 150.0 nM
COc1ccc(-c2nc(Nc3cccc(NC(=O)N4CCCC4)c3)nc3[nH]cnc23)cc1 CHEMBL1933347 IC50 150.0 nM
CCN(c1cc(-c2c[nH]c3ncc(-c4cnn(C)c4)cc23)nc(N)n1)c1nncs1 CHEMBL3652577 IC50 155.0 nM
O=C(NCC#Cc1ccc2nccc(OCC3CCCO3)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689290 IC50 156.0 nM
CN1CCCN(c2ncnc3ccc(C#CCNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)cc23)CC1 CHEMBL3640466 IC50 156.0 nM
COCCCNc1ncnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640451 IC50 158.0 nM
CCNc1cc(-c2ccc3c(N)[nH]nc3c2)nc(N)n1 CHEMBL1614771 pIC50 158.49 nM
Cc1ccc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)cc1 CHEMBL1972576 pKi 158.49 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 158.49 nM
NCCC(C(=O)Nc1ccc2[nH]ncc2c1)c1ccc(Cl)c(Cl)c1 CHEMBL1998121 pKi 158.49 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(O)c2)n1 CHEMBL243088 pKi 158.49 nM
CC(C)n1cc(-c2cc(C(N)=O)c3ncnc(N[C@H]4CCCNC4)c3c2)cn1 CHEMBL3685317 IC50 160.0 nM
O=C(NCC#Cc1ccc2ncnc(NCCc3cccs3)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3640449 IC50 161.0 nM
O=C(NCC#Cc1ccc2nccc(OCC3CCCCO3)c2c1)c1cccn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689278 IC50 166.0 nM
COc1ccc(-c2nc(Nc3cccc(NC(=O)N4CCCC4)c3)nc3[nH]cnc23)cc1OC CHEMBL2023196 IC50 170.0 nM
CCc1cc(-c2c[nH]c3ncc(-c4ccc(N)nc4)cc23)nc(N)n1 CHEMBL3814154 IC50 170.0 nM
CC1=NN(C(=O)c2ccccc2)C(=O)C1/N=N/c1ccc(S(=O)(=O)Nc2ncccn2)cc1 CHEMBL595581 Kd 170.0 nM
CN1CC(Nc2ncnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc23)C1 CHEMBL3640439 IC50 171.0 nM
CN(C)C(=O)CNc1ncnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640487 IC50 182.0 nM
O=C(NCC#Cc1ccc2ncnc(NCC(O)c3ccccc3)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3640450 IC50 184.0 nM
CN(Cc1ccccc1)c1c(C#N)cnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640531 IC50 184.0 nM
CN(C)C(=O)c1cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc2n1 CHEMBL3950250 IC50 185.0 nM
Cc1c(C#CCNC(=O)c2cncn(Cc3ccc(F)c(F)c3)c2=O)ccc2ncc(C(=O)N(C)C)cc12 CHEMBL3689254 IC50 185.0 nM
CN(c1cccc(F)c1)c1cc(-c2c[nH]c3ncc(-c4cnn(C)c4)cc23)ncn1 CHEMBL3652587 IC50 190.0 nM
CNc1ncnc2ccc(C#CCNC(=O)c3cccn(Cc4ccsc4)c3=O)cc12 CHEMBL3640463 IC50 199.0 nM
CC(C)[C@@H]1COCCN1c1cc(-c2ccc3c(N)n[nH]c3c2)nc(N)n1 CHEMBL1765729 pIC50 199.53 nM
Nc1nc(-c2ccccc2)cc(-c2ccc3c(N)n[nH]c3c2)n1 CHEMBL1765758 pIC50 199.53 nM
Cc1n[nH]c2cnc(-c3cncc(OCC(N)Cc4cccc(C(F)(F)F)c4)c3)cc12 CHEMBL1998159 pKi 199.53 nM
O=C1Nc2ccc(-n3ncnn3)cc2/C1=C/c1ccc[nH]1 CHEMBL232143 IC50 200.0 nM
COc1cc2c(cc1OCCCN(C)C)ncc1c(N)nc3c(C)c(N)ccc3c12 CHEMBL393328 IC50 200.0 nM
CCOC(=O)c1ccc(Nc2cc(C)nc(Nc3ccc(C(=O)OCC)cc3)n2)cc1 CHEMBL1951891 IC50 200.0 nM
CN[C@@H]1CCc2ccccc21 CHEMBL1235698 IC50 200.0 nM
NC(=O)c1cc(C2=CCC(C(N)=O)C=C2)cc2c(N[C@H]3CCCNC3)ncnc12 CHEMBL3685318 IC50 200.0 nM
Cn1cc(-c2cnc3[nH]cc(-c4cc(N5CCc6cc(F)ccc65)nc(N)n4)c3c2)cn1 CHEMBL3652574 IC50 200.0 nM
O=C(Nc1ccc2[nH]nc(-c3nc4ccc(N5CCOCC5)cc4[nH]3)c2c1)C1CCC(F)(F)CC1 CHEMBL3659972 IC50 200.0 nM
O=C(Nc1ccc2[nH]nc(-c3nc4ccc(N5CCOCC5)cc4[nH]3)c2c1)C1CC1 CHEMBL3659971 IC50 200.0 nM
CN(C)CCCN(C)C(=O)c1cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc2c1 CHEMBL3640512 IC50 201.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn(CC5CCCOC5)c4=O)cc3c2n1C(C)C CHEMBL3644721 IC50 202.0 nM
CN1CCC(Oc2ccnc3ccc(C#CCNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)cc23)C1 CHEMBL3689276 IC50 212.0 nM
O=C(CNc1ncnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12)c1ccccc1 CHEMBL3640453 IC50 218.0 nM
COc1ccc(-c2nc(Nc3cccc(NC(=O)N4CCCCC4)c3)nc3[nH]cnc23)cc1 CHEMBL2023416 IC50 220.0 nM
O=C(NCCCNc1nc(Nc2cccc(F)c2)ncc1Br)C1CCCC1 CHEMBL2207180 IC50 220.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn(C[C@H]5CCCC[C@H]5O)c4=O)cc3c2n1C(C)C CHEMBL3644720 IC50 221.0 nM
Nc1ncnc2cc(Cl)c(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640547 IC50 229.0 nM
CN(C)CCNc1ncnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640447 IC50 229.0 nM
CC(C)=Cc1cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc2n1 CHEMBL3689238 IC50 233.0 nM
Cc1nc2cnc3ccc(C#Cc4cccnc4)cc3c2n1-c1ccc(C(C)C#N)cc1 CHEMBL270638 IC50 245.0 nM
CC(C)c1cc(-c2ccc3c(N)n[nH]c3c2)nc(N)n1 CHEMBL1765757 pIC50 251.19 nM
COc1cc(-c2ccc3c(N)n[nH]c3c2)nc(N)n1 CHEMBL1765759 pIC50 251.19 nM
Nc1nc(-c2ccc3c(N)n[nH]c3c2)cc(N2CCCC2)n1 CHEMBL1765878 pIC50 251.19 nM
Nc1nc(-c2ccc3c(N)n[nH]c3c2)cc(N2CCCCC2)n1 CHEMBL1765879 pIC50 251.19 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3I)cc12 CHEMBL1975128 pKi 251.19 nM
O=C1CCCN1Cc1ccc2c(c1)[nH]c(=O)c1cccn12 CHEMBL539474 pKi 251.19 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 pKi 251.19 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccccc1 CHEMBL1999931 pKi 251.19 nM
COc1cccc(CNC(=O)c2cc3c(-c4ccccc4)n[nH]c3s2)c1 CHEMBL1987009 pKi 251.19 nM
NC(COc1cncc(-c2cc3ccncc3s2)c1)Cc1c[nH]c2ccccc12 CHEMBL1966524 pKi 251.19 nM
Cc1ccccc1NC(=O)Nc1ccc(NC(=O)c2csc3ncnc(N)c23)cc1 CHEMBL1980144 pKi 251.19 nM
O=C1Nc2ccc(C(=O)O)cc2/C1=C/c1ccc[nH]1 CHEMBL107225 IC50 260.0 nM
COc1cc2ncc3c(N)nc4c(C)cccc4c3c2cc1OC CHEMBL235377 IC50 260.0 nM
CN1CCN(Cc2cccc(-c3nc(Nc4cccc(Cl)c4)nc4[nH]cnc34)c2)CC1 CHEMBL2023195 IC50 260.0 nM
CCc1cc(-c2c[nH]c3ncc(-c4ccn[nH]4)cc23)nc(N)n1 CHEMBL3814539 IC50 260.0 nM
CCOc1cc2ncc3c(N)nc4c(C)c(N)ccc4c3c2cc1OCC CHEMBL235602 IC50 270.0 nM
CCN(CC)c1c(C#N)cnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640533 IC50 276.0 nM
CN(C)CCn1cnc2cnc3ccc(C#CCNC(=O)c4cccn(Cc5ccccc5)c4=O)cc3c21 CHEMBL3644737 IC50 277.0 nM
Cc1c[nH]c(/C=C2\C(=O)Nc3ccc(O)cc32)c1 CHEMBL232135 IC50 280.0 nM
Cc1cc[nH]c1/C=C1\C(=O)Nc2ccc(O)cc21 CHEMBL232134 IC50 280.0 nM
O=C(Nc1cccc(Nc2nc(-c3ccc4c(c3)OCO4)c3nc[nH]c3n2)c1)N1CCCC1 CHEMBL2023197 IC50 280.0 nM
O=C(Nc1ccc2[nH]nc(-c3nc4ccccc4[nH]3)c2c1)C1CC1(F)F CHEMBL3659976 IC50 280.0 nM
COc1cc2ncc3c(N)nc(-c4cncc(Nc5ccccc5)c4)cc3c2cc1OC CHEMBL570727 IC50 283.0 nM
O=C(NCC#Cc1ccc2ncc(C(=O)N3CCNCC3)cc2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3640516 IC50 286.0 nM
NS(=O)(=O)c1ccc2c(c1)/C(=C/c1ccc[nH]1)C(=O)N2 CHEMBL441911 IC50 290.0 nM
COc1cc2c(cc1NCCCN1CCOCC1)ncc1c(N)nc3c(C)c(N)ccc3c12 CHEMBL235783 IC50 290.0 nM
COc1cc2c(cc1NCCN1CCOCC1)ncc1c(N)nc3c(C)cccc3c12 CHEMBL235782 IC50 300.0 nM
CS(=O)(=O)Nc1ccc2c(c1)/C(=C/c1cnc[nH]1)C(=O)N2 CHEMBL3736436 IC50 310.0 nM
O=C(NCC#Cc1ccc2ncnc(O)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3640548 IC50 311.0 nM
Nc1nc(-c2ccc3c(N)[nH]nc3c2)cc(N2CCOCC2)n1 CHEMBL1614772 pIC50 316.23 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 316.23 nM
O=C(NCc1ccc(Cl)cc1)c1cc2c(-c3ccccc3)n[nH]c2s1 CHEMBL1967094 pKi 316.23 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1970317 pKi 316.23 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CCO)c5)cnc(N)c34)cc2F)c1 CHEMBL1986851 pKi 316.23 nM
CCc1nc2cnc3ccc(C#Cc4cccnc4)cc3c2n1-c1ccc(CC#N)cc1 CHEMBL270640 IC50 327.0 nM
Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cc(Cl)cnc12 CHEMBL4552628 IC50 330.0 nM
O=C1Nc2ccc(O)cc2/C1=C/c1ccc[nH]1 CHEMBL393636 IC50 340.0 nM
N#Cc1ccc(-c2ccc3ncnc(NC4CCCNC4)c3c2)cc1 CHEMBL3685319 IC50 340.0 nM
CN(C)C(=O)c1cnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc2c1 CHEMBL3640519 IC50 355.0 nM
CNc1ncnc2ccc(C#CCNC(=O)c3cc(NCCN(C)C)nn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640494 IC50 357.0 nM
Nc1nccc(-c2ccc3c(N)n[nH]c3c2)n1 CHEMBL1688215 IC50 370.0 nM
CN(c1ncnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12)C1CCCCC1 CHEMBL3640459 IC50 371.0 nM
NC(=O)c1nn(CC2CCNCC2)c2c1CCc1cnc(Nc3ccccc3)nc1-2 CHEMBL1171949 IC50 374.0 nM
COc1ccc(Nc2cncc(-c3cc4c(cnc5cc(OC)c(OC)cc54)c(N)n3)c2)cc1 CHEMBL569828 IC50 383.0 nM
O=C(Nc1cccc2[nH]nc(-c3nc4ccc(N5CCOCC5)cc4[nH]3)c12)C1CC1(F)F CHEMBL3659978 IC50 385.0 nM
CN1C/C=C/CCOc2cccc(c2)-c2nc(nc3[nH]cnc23)Nc2cccc(c2)C1 CHEMBL1933344 IC50 390.0 nM
NCCCc1cc(-c2c[nH]c3ncccc23)nc(N)n1 CHEMBL3814554 IC50 390.0 nM
NC(=O)c1cccc(-c2cc(C(N)=O)c3ncnc(N[C@H]4CCCNC4)c3c2)c1 CHEMBL3685320 IC50 390.0 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(-c4ccccc4)c3n2)c1 CHEMBL1988163 pKi 398.11 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(Cc4ccccc4)c3n2)c1 CHEMBL1993424 pKi 398.11 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(CCOc4ccc(N5CCOCC5)cc4)cc2NC3=O)ccc1OCC(O)CO CHEMBL1981045 pKi 398.11 nM
Nc1ncc(-c2ccncc2)c2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1970083 pKi 398.11 nM
O=C(Nc1cccc(Nc2nc(-c3ccc(F)nc3)c3nc[nH]c3n2)c1)N1CCCC1 CHEMBL2023199 IC50 400.0 nM
O=C(Nc1ccc2[nH]nc(-c3nc4ccccc4[nH]3)c2c1)C1CCC(F)(F)CC1 CHEMBL3659974 IC50 400.0 nM
CCN1CCN(C(=O)c2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c2)CC1 CHEMBL3640511 IC50 402.0 nM
CN1CCN(C(=O)c2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3c2)CC1 CHEMBL3640517 IC50 405.0 nM
COc1cc(-c2nc(Nc3cccc(NC(=O)N4CCCC4)c3)nc3[nH]cnc23)ccc1N CHEMBL2023200 IC50 410.0 nM
CN(CCc1ccccc1)c1c(C#N)cnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640539 IC50 414.0 nM
O=C1Nc2ccc(NC(=O)[C@H](NC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)c3ccccc3)cc2/C1=C/c1cnc[nH]1 CHEMBL3823844 IC50 416.0 nM
CC1=NN(C(=O)c2ccc(O)cc2)C(=O)C1/N=N/c1ccc(S(=O)(=O)Nc2ncccn2)cc1 CHEMBL595347 Kd 420.0 nM
COc1cccc(Nc2cncc(-c3cc4c(cnc5cc(OC)c(OC)cc54)c(N)n3)c2)c1 CHEMBL569153 IC50 434.0 nM
O=C(NCC#Cc1ccc2ncnc(N3CCNCC3)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3640446 IC50 443.0 nM
CC(CNc1ncnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12)c1ccccc1 CHEMBL3640452 IC50 445.0 nM
CCc1cc(-c2c[nH]c3ncc(-c4ccncc4)cc23)nc(N)n1 CHEMBL3813886 IC50 450.0 nM
CC1(CNc2ncnc3ccc(C#CCNC(=O)c4cccn(Cc5ccc(F)c(F)c5)c4=O)cc23)COC1 CHEMBL3640473 IC50 468.0 nM
CCc1cc(-c2c[nH]c3ncc(Br)cc23)nc(N)n1 CHEMBL3814704 IC50 480.0 nM
CNc1ncnc2ccc(C#CCNC(=O)c3cncn(Cc4ccccc4F)c3=O)cc12 CHEMBL3640490 IC50 486.0 nM
NC(=O)[C@@H](Cc1ccccc1)Nc1ncnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640454 IC50 488.0 nM
CCc1cc(-c2c[nH]c3ncc(-c4cccnc4)cc23)nc(N)n1 CHEMBL3814357 IC50 500.0 nM
CN(c1ncnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12)C(C)(C)C CHEMBL3640456 IC50 500.0 nM
CN(C)c1cc(-c2ccc3c(N)n[nH]c3c2)nc(N)n1 CHEMBL1765877 pIC50 501.19 nM
Cc1cc(N2CCOCC2)cc2[nH]c(-c3c(NCC(O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL2005886 pKi 501.19 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 501.19 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(OC(F)F)cc5)cc4)csc23)cn1 CHEMBL1988387 pKi 501.19 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 pKi 501.19 nM
COc1cc2ncc3c(N)nc(-c4cncc(Nc5ccccc5Nc5ccccc5)c4)cc3c2cc1OC CHEMBL585340 IC50 505.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn([C@H](C)C5CCCCC5)c4=O)cc3c2n1C(C)C CHEMBL3644702 IC50 507.0 nM
Cc1cccc2c1/C(=C/c1ccc[nH]1)C(=O)N2 CHEMBL85403 IC50 510.0 nM
NC(=O)c1cc(-c2ccccc2)cc2c(N[C@H]3CCCNC3)ncnc12 CHEMBL3685321 IC50 510.0 nM
O=C1Nc2ccc(NC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc2/C1=C/c1cnc[nH]1 CHEMBL3824264 IC50 512.0 nM
O=C(NCC#Cc1ccc2ncnc(NC3CCOCC3)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3640458 IC50 515.0 nM
O=C1Nc2ccccc2/C1=C/c1ccc[nH]1 CHEMBL86755 IC50 520.0 nM
NC(=O)c1cc(-c2ccc(Cl)c(Cl)c2)cc2c(NC3CCCNC3)ncnc12 CHEMBL3685322 IC50 520.0 nM
CS(=O)(=O)Nc1ccc2c(c1)/C(=C/c1ccc[nH]1)C(=O)N2 CHEMBL232360 IC50 530.0 nM
O=C(NCC#Cc1ccc2ncc(C(=O)N3CCOCC3)cc2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3640515 IC50 531.0 nM
COc1cc2ncc3c(N)nc(-c4cccnc4C)cc3c2cc1OC CHEMBL571163 IC50 532.0 nM
CN(c1c(C#N)cnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12)C1CCCCC1 CHEMBL3640528 IC50 544.0 nM
CN(C)CCCNc1ccnc2ccc(C#CCNC(=O)c3cncn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689288 IC50 554.0 nM
COc1ccccc1C1=C(c2cn(CCCNC(=O)OC(C)(C)C)c3ncccc23)C(=O)NC1=O CHEMBL109981 IC50 570.0 nM
Nc1ccc2c(c1)/C(=C/c1ccc[nH]1)C(=O)N2 CHEMBL232144 IC50 580.0 nM
COc1ccc2c(c1)/C(=C/c1ccc[nH]1)C(=O)N2 CHEMBL232349 IC50 580.0 nM
COc1cc2c(cc1F)ncc1c(N)nc3c(C)c(N)ccc3c12 CHEMBL236474 IC50 580.0 nM
O=C(NCCCNc1nc(Nc2cccc(F)c2)ncc1C1CC1)C1CCC1 CHEMBL2207187 IC50 580.0 nM
O=C(NCC#Cc1ccc2ncc(NC3CCCCC3)nc2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689197 IC50 588.0 nM
Cc1nc2cnc3ccc(C#CCNC(=O)c4cccn(CC5CCOCC5)c4=O)cc3c2n1C(C)C CHEMBL3644716 IC50 590.0 nM
N#Cc1cnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc2c1NCCc1ccccc1 CHEMBL3640529 IC50 607.0 nM
NC(=O)c1cc(-c2cnoc2)cc2c(NC3CCCNC3)ncnc12 CHEMBL3685323 IC50 610.0 nM
C[C@@H]1CC[C@H](NC(=O)OC(C)(C)C)CN1c1cc(-c2ccc3c(N)n[nH]c3c2)nc(N)n1 CHEMBL1765749 pIC50 630.96 nM
CC(N)C1CCC(C(=O)Nc2ccnc3[nH]ccc23)CC1 CHEMBL2002992 pKi 630.96 nM
NC(=O)c1cccc(-c2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982957 pKi 630.96 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 pKi 630.96 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(C)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1984162 pKi 630.96 nM
CN1CCC(NC(=O)c2cc3c(-c4ccccc4)n[nH]c3s2)CC1 CHEMBL1987007 pKi 630.96 nM
COc1cccc2c1Nc1cc(Nc3ccncc3)ccc1C(=O)N2 CHEMBL2006276 pKi 630.96 nM
Cc1[nH]c(C=C2C(=O)Nc3ccccc32)c(C)c1CCC(=O)O CHEMBL2007064 pKi 630.96 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 650.0 nM
O=C(NCC#Cc1ccc2ncc(CC3CCNCC3)nc2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689236 IC50 654.0 nM
CN(C)CCCNc1ccnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689289 IC50 656.0 nM
COC(=O)c1ccc2c(c1)/C(=C/c1ccc[nH]1)C(=O)N2 CHEMBL231947 IC50 670.0 nM
COc1cc2ncc3c(N)nc4cc(N)ccc4c3c2cc1OC CHEMBL235160 IC50 670.0 nM
Cc1ccc(/C=C2\C(=O)Nc3ccc(O)cc32)[nH]1 CHEMBL232136 IC50 680.0 nM
NC[C@@H](c1ccccc1)n1cccc(C(=O)NCC#Cc2ccc3ncc4ncn(C5CCOC5)c4c3c2)c1=O CHEMBL3644756 IC50 681.0 nM
CN(CC1CCCCC1)c1c(C#N)cnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3640532 IC50 683.0 nM
CN(C)c1ncnc2ccc(C#CCNC(=O)c3cccn(Cc4ccn[nH]4)c3=O)cc12 CHEMBL3640479 IC50 697.0 nM
CN(C)C[C@@H]1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1 CHEMBL91829 Kd 700.0 nM
Cc1cc(CNC(=O)c2nn(C)c3c2CCc2cnc(Nc4ccc(N5CCN(C)CC5)cc4)nc2-3)ccn1 CHEMBL1169805 IC60 713.0 nM
COCCOc1cc2ncc3c(N)nc(N(C)C)cc3c2cc1OC CHEMBL569345 IC50 739.0 nM
N#Cc1ncc2nc1OCCCCCOc1cc(CCCO)c(Cl)cc1NC(=O)N2 CHEMBL223367 Ki 740.0 nM
CC(Nc1ncnc2c(C(N)=O)cc(-c3cnn(C)c3)cc12)c1cccc(F)c1 CHEMBL3685324 IC50 750.0 nM
CNc1ncnc2ccc(C#CCNC(=O)c3cccn(Cc4ccoc4)c3=O)cc12 CHEMBL3640488 IC50 770.0 nM
CC1CCN(c2ccc3nc(-c4n[nH]c5ccc(NC(=O)C6CC6(F)F)cc45)[nH]c3c2)CC1 CHEMBL3659973 IC50 780.0 nM
O=C(NCC#Cc1ccc2nccc(NC3CC3)c2c1)c1cncn(Cc2ccc(F)c(F)c2)c1=O CHEMBL3689284 IC50 780.0 nM
CN1CCC[C@@H](n2cnc3cnc4ccc(C#CCNC(=O)c5cc(Cl)nn(Cc6ccc(F)c(F)c6)c5=O)cc4c32)C1 CHEMBL3644745 IC50 787.0 nM
NC(=O)c1cc(/C=C/c2ccccc2)cc2c(N[C@H]3CCCNC3)ncnc12 CHEMBL3685325 IC50 790.0 nM
C[C@@H]1CC[C@@H](C(=O)Nc2ccccc2)CN1c1cc(-c2ccc3c(N)n[nH]c3c2)nc(N)n1 CHEMBL1765737 pIC50 794.33 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1998585 pKi 794.33 nM
CNC(=O)COc1ccc(Nc2nc(Nc3ccc(C)c(S(N)(=O)=O)c3)ncc2F)cc1 CHEMBL1978099 pKi 794.33 nM
CCN(CC)CCNC(=O)C=Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL2004716 pKi 794.33 nM
O=C(O)c1ccc(Nc2ncc3c(n2)-c2ccc(Cl)cc2C(c2c(F)cccc2F)=NC3)cc1 CHEMBL259084 pKi 794.33 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)O)c5)cnc(N)c34)cc2)c1 CHEMBL1989708 pKi 794.33 nM
NC(=O)c1ccc(-c2c[nH]c3nccc(Cl)c23)cc1 CHEMBL1982711 pKi 794.33 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cn[nH]c5)cnc(N)c34)cc2)c1 CHEMBL1969102 pKi 794.33 nM
Cc1cncc2cccc(S(=O)(=O)N3CCCNCC3C)c12 CHEMBL1082440 pKi 794.33 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)csc12 CHEMBL2005631 pKi 794.33 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 pKi 794.33 nM
Cn1cc(-c2cc(C(N)=O)c3ncnc(NCc4cccc(F)c4)c3c2)cn1 CHEMBL3685326 IC50 800.0 nM
CN(C)CCNc1ccnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc12 CHEMBL3689287 IC50 853.0 nM
Cn1cc(-c2cnc3[nH]cc(-c4cc(C5(c6ccc(Cl)cc6)CCCC5)nc(N)n4)c3c2)cn1 CHEMBL3652564 IC50 870.0 nM
N#Cc1cnc2ccc(C#CCNC(=O)c3cccn(Cc4ccc(F)c(F)c4)c3=O)cc2c1NCc1ccccc1 CHEMBL3640535 IC50 871.0 nM
O=C1Nc2cc(O)ccc2/C1=C/c1ccc[nH]1 CHEMBL231716 IC50 900.0 nM
O=C(Nc1ccc2[nH]nc(-c3nc4ccccc4[nH]3)c2c1)NC1CC1 CHEMBL3659980 IC50 900.0 nM
CN1CCC(Cc2cnc3ccc(C#CCNC(=O)c4cncn(Cc5ccc(F)c(F)c5)c4=O)cc3n2)CC1 CHEMBL3689237 IC50 940.0 nM
COc1cc2c(cc1NCCCN(C)C)ncc1c(N)nc3c(C)c(N)ccc3c12 CHEMBL238133 IC50 970.0 nM
COc1ccc(-c2nc(Nc3cccc(Cl)c3)nc3[nH]cnc23)cc1OC CHEMBL2023194 IC50 970.0 nM
COc1cc2c(cc1OC)CN(CC(=O)Nc1ccc3c(c1)/C(=C/c1cnc[nH]1)C(=O)N3)CC2 CHEMBL3091673 IC50 980.0 nM
CC1=NN(C(=O)c2ccc(Cl)cc2)C(O)C1/N=N/c1ccc(S(=O)(=O)Nc2ncccn2)cc1 CHEMBL3923074 Kd 980.0 nM
N#Cc1ccc2c(c1)/C(=C/c1ccc[nH]1)C(=O)N2 CHEMBL393840 IC50 990.0 nM