CN(C)C1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)nc(N5CCOCC5)n4)cc3)cc2)CC1 CHEMBL592445 Kd 0.46 nM
Cc1nc2sc1-c1cc3c(c(c1)S(=O)(=O)NCCOCCNC(=O)c1cccc(n1)N2)C(=O)N([C@@H](C)C1CC1)C3 CHEMBL5091438 pIC50 0.7943 nM
Cc1nc(Nc2cccc(N3CCOCC3=O)n2)sc1-c1cc2c(c(S(=O)(=O)NC3COC3)c1)C(=O)N([C@@H](C)C1CC1)C2 CHEMBL5077865 pIC50 1.0 nM
Cc1nc(Nc2cccc(N3CCCC3=O)n2)sc1-c1cc2c(c(S(C)(=O)=O)c1)C(=O)N([C@@H](C)C1CC1)C2 CHEMBL4558527 pIC50 3.162 nM
O=C(CCCCCCn1cnc2c(N3CCOCC3)nc(-c3cccc(CO)c3)nc21)NO CHEMBL4749655 Kd 4.9 nM
Nc1nc(N)c2nc(-c3cccc(O)c3)c(-c3cccc(O)c3)nc2n1 CHEMBL230011 Kd 7.3 nM
CN(C)C(=O)c1ccc2c(c1)c(C[C@H]1COCCN1c1nc3c(s1)C(=O)NC(C)(C)C3)cn2C CHEMBL4869265 IC50 9.57 nM
Oc1cccc(-c2nc(N3CCOCC3)c3oc4ncccc4c3n2)c1 CHEMBL538346 IC50 10.0 nM
Oc1cccc(-c2nc(N3CCOCC3)c3oc4ncccc4c3n2)c1 CHEMBL573339 Kd 10.0 nM
Nc1ccc(-c2ccc3ncc4ccc(=O)n(-c5cccc(C(F)(F)F)c5)c4c3c2)cn1 CHEMBL1765602 IC50 24.5 nM
Oc1cccc(-c2cc3c(oc4ncccc43)c(N3CCOCC3)n2)c1 CHEMBL3913354 IC50 26.0 nM
COc1ccc(Nc2ncc(CN3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165017 IC50 29.0 nM
CC(=O)Nc1nc(C)c(-c2cc3c(c(S(C)(=O)=O)c2)C(=O)N([C@@H](C)C2CC2)C3)s1 CHEMBL4126156 pIC50 31.62 nM
CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL521851 Kd 40.0 nM
COc1c(OCc2cccc([N+](=O)[O-])c2)ccc2c1N=C(NC(=O)c1ccc(N)nc1)N1CCN=C21 CHEMBL5405102 IC50 43.0 nM
Cn1c(=O)n(-c2ccc(C3(C#N)CC3)cc2)c2c3cc(-c4cnc5ccccc5c4)ccc3ncc21 CHEMBL3354566 IC50 44.0 nM
Cn1c(=O)n(-c2ccc(C(C)(C)C#N)cc2)c2c3cc(-c4cnc5ccccc5c4)ccc3ncc21 CHEMBL1879463 IC50 44.0 nM
COc1ccc2c(c1OC)N=C(NC(=O)c1cccnc1)N1CCN=C21 CHEMBL1241857 IC50 64.0 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)c1nc(-c2cnc3ccc(Cl)cn23)cs1 CHEMBL541133 IC50 100.0 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnc2ccc(Br)cn12 CHEMBL556399 IC50 100.0 nM
CC(=O)/N=c1/[nH]c(C)c(-c2ccc(Cl)c(S(=O)(=O)NCCO)c2)s1 CHEMBL1229535 IC50 140.0 nM
FC(F)c1nc2ccccc2n1-c1nc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL586702 IC50 180.0 nM
Oc1cccc(-c2nc(N3CCOCC3)c3sccc3n2)c1 CHEMBL541643 IC50 220.0 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 220.0 nM
Cc1ccc(S(=O)(=O)Nc2cc(-c3sc(NC(=O)[C@@H](N)C(C)C)nc3C)cnc2Cl)cc1 CHEMBL4164334 IC50 247.9 nM
Nc1ncc(-c2nc(N3CCOCC3)c3ccn(CCCCCCC(=O)NO)c3n2)cn1 CHEMBL4744689 Kd 260.0 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C(C)(C)C(N)=O)c4)cc2OCC3)n(C(C)C)n1 CHEMBL2387080 IC50 292.0 nM
Cc1nc(CN(C)c2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)cs1 CHEMBL1474834 Kd 340.0 nM
O=C1NC(=S)S/C1=C/c1ccc2c(c1)N(Cc1ccc(F)c(Cl)c1)C(=O)CO2 CHEMBL3218571 IC50 370.0 nM
O=C1NC(=S)S/C1=C\c1ccc2c(c1)N(Cc1ccc(F)c(Cl)c1)C(=O)CO2 CHEMBL3922359 IC50 370.0 nM
c1nc(NCC2CCOC2)c2cc(-c3ccc4c(c3)OCO4)ccc2n1 CHEMBL1436585 Kd 410.0 nM
O=C(Cc1cccs1)Nc1cccc(-c2ccc3nnc(-c4cccnc4)n3n2)c1 CHEMBL2093753 IC50 430.0 nM
CN1CCC(NC(=O)c2ccc(-c3ccc(-n4c(=O)ccc5cnc6ccc(-c7cnc8ccccc8c7)cc6c54)cc3C(F)(F)F)cc2)CC1 CHEMBL1795875 IC50 437.0 nM
Cc1nc(NC(=O)N2CCC[C@H]2C(N)=O)sc1-c1csc(C(C)(C)C)n1 CHEMBL3218581 IC50 462.0 nM
CC(=O)Nc1ccc2nc(-c3cccc(NS(=O)(=O)c4cccc5ccccc45)c3)nc(N3CCOCC3)c2c1 CHEMBL3354564 IC50 530.0 nM
CC(=O)Nc1ccc2nc(-c3cccc(NS(=O)(=O)c4ccc5ccccc5c4)c3)nc(N3CCOCC3)c2c1 CHEMBL3903959 IC50 530.0 nM
Nc1ncc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)c(C(F)(F)F)n1 CHEMBL4102855 Kd 540.0 nM
CCC(=O)N1CCN(c2ccc(-n3c(=O)ccc4cnc5ccc(-c6cnc7ccccc7c6)cc5c43)cc2C(F)(F)F)CC1 CHEMBL1256459 IC50 549.0 nM
Cc1c(CN2CCN(C(=O)[C@H](C)O)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1922094 Kd 580.0 nM
CC(=O)Nc1ccc2nc(-c3cccc(NS(=O)(=O)c4ccccc4)c3)nc(N3CCOCC3)c2c1 CHEMBL3354565 IC50 630.0 nM
CS(=O)(=O)CCNCc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1 CHEMBL554 Kd 670.0 nM
Nc1cc(C(F)(F)F)c(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cn1 CHEMBL4084907 Kd 820.0 nM
Cc1cccc(S(=O)(=O)Nc2cc(-c3sc(NC(=O)[C@@H](N)C(C)C)nc3C)cnc2Cl)c1 CHEMBL4174988 IC50 882.3 nM