COc1ncc(-c2ccc3nccc(-c4ccnnc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL1236962 Ki 0.019 nM
CC(C)n1nc(N)nc1-c1cn2c(n1)-c1ccc(N3CCC[C@H]3C(N)=O)cc1OCC2 CHEMBL5208487 Ki 0.026 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1ccc(N3CCC[C@H]3C(N)=O)cc1OCC2 CHEMBL3770993 Ki(app) 0.03 nM
C[C@H](Nc1ccc2c(c1)OCCn1cc(N3C(=O)OC[C@H]3C(F)F)nc1-2)C(N)=O CHEMBL4650215 Ki 0.034 nM
CC(C)n1nc(N)nc1-c1nc2c(s1)CCOc1cc(-c3cnn(CCO)c3)ccc1-2 CHEMBL2381382 Ki(app) 0.04 nM
CC(C)[C@@H]1COC(=O)N1c1cn2c(n1)-c1ccc(N3CCC[C@H]3C(N)=O)cc1OCC2 CHEMBL5199631 Ki 0.042 nM
NC(=O)[C@@H]1CCCN1c1ccc2c(c1)OCCn1cc(N3C(=O)OC[C@H]3CF)nc1-2 CHEMBL5198796 Ki 0.043 nM
NC(=O)[C@@H](Nc1ccc2c(c1)OCCn1cc(N3C(=O)OC[C@H]3CF)nc1-2)C1CC1 CHEMBL5186155 Ki 0.051 nM
NC(=O)[C@@H]1CCCN1c1ccc2c(c1)OCCn1cc(N3C(=O)OC[C@H]3C(F)F)nc1-2 CHEMBL5209168 Ki 0.053 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3cnn(CCN)c3)ccc1-2 CHEMBL2381376 Ki(app) 0.06 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3cnn(CS(C)(=O)=O)c3)ccc1-2 CHEMBL2381375 Ki(app) 0.06 nM
NC(=O)[C@@H](Nc1ccc2c(c1)OCCn1cc(N3C(=O)OC[C@H]3C(F)F)nc1-2)C1CC1 CHEMBL5196718 Ki 0.06 nM
COc1ncc(-c2ccc3ncc(-c4cn(CCCN5CCOCC5)nn4)n3n2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL5395998 IC50 0.06 nM
C[C@H](Oc1ccc2c(c1)OCCn1cc(-c3nc(CO)nn3CC(F)(F)F)nc1-2)C(N)=O CHEMBL5209048 Ki 0.062 nM
COc1ncc(-c2ccc3nc(N)nc(-c4ccncc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3577914 IC50 0.07 nM
COc1ncc(-c2ccc3ncc(-c4cn(CCN5CCOCC5)nn4)n3n2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL5422635 IC50 0.08 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C(C)(C)C(N)=O)c4)cc2OCC3)n(C(C)C)n1 CHEMBL2387080 Ki 0.09 nM
COc1ncc(-c2ccc3ncnc(-c4ccncc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3577911 IC50 0.095 nM
C[C@H](Nc1ccc2c(c1)OCCn1cc(N3C(=O)OC[C@H]3C(F)(F)F)nc1-2)C(N)=O CHEMBL5205438 Ki 0.095 nM
CO[C@@H]1CCN(c2ccc3c(c2)OCCn2cc(N4C(=O)OC[C@H]4C(F)(F)F)nc2-3)[C@@H]1C(N)=O CHEMBL5181348 Ki 0.097 nM
COc1ncc(-c2ccc3nccc(-c4ccncc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3577908 IC50 0.1 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1ccc(N3CC[C@H]3C(N)=O)cc1OCC2 CHEMBL3770306 Ki(app) 0.1 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1cnc(N3CCC[C@H]3C(N)=O)cc1OCC2 CHEMBL3770709 Ki(app) 0.1 nM
NC(=O)[C@@H](Nc1ccc2c(c1)OCCn1cc(N3C(=O)OC[C@H]3C(F)(F)F)nc1-2)C1CC1 CHEMBL5182371 Ki 0.1 nM
CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL521851 IC50 0.1 nM
CN(C)c1ccc(-c2ccc3ncc4c(c3n2)n([C@H]2CC[C@H](OCCO)CC2)c(=O)n4C)cn1 CHEMBL3639799 Ki 0.102 nM
CC(C)n1nc(N)nc1-c1cn2c(n1)-c1ccc(O[C@@H](C)C(N)=O)cc1OCC2 CHEMBL5182339 Ki 0.107 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3cnn(C(C)(C)C(N)=O)c3)ccc1-2 CHEMBL2381377 Ki(app) 0.11 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C5CN(CCO)C5)c4)cc2OCC3)n(C(C)C)n1 CHEMBL2386970 Ki 0.11 nM
C[C@@H](O)C(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6[nH]ncc6c5)nc4c32)CC1 CHEMBL3681175 Ki 0.11 nM
COc1ncc(-c2ccc3ncc(-c4cn(CCN(C)C)nn4)n3n2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL5400439 IC50 0.11 nM
COc1c(OCCCN2CCOCC2)ccc2c1N=C(NC(=O)c1cnc(N)nc1)N1CCN=C21 CHEMBL3218576 IC50 0.11 nM
Cn1c(=O)n(C2CCN(C(=O)C(C)(C)O)CC2)c2c3nc(-c4cnc5[nH]ncc5c4)ccc3ncc21 CHEMBL3681177 Ki 0.114 nM
Oc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL1910998 IC50 0.12 nM
Cc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)[C@H](C)O)CC2)c(=O)n4C)cn1 CHEMBL2331664 Ki 0.13 nM
CC(C)n1nc(N)nc1-c1nc2c(s1)CCOc1cc(-c3cnn(CC(C)(C)O)c3)ccc1-2 CHEMBL2381380 Ki(app) 0.13 nM
COc1ncc2cc1NS(=O)(=O)c1ccc(F)c(c1)C(=O)NCc1ccc(s1)-c1ncnc3c(C)c-2sc13 CHEMBL4878958 IC50 0.13 nM
CC(C)(O)Cn1cc(-c2ccc3c(c2)OCCc2sc(-c4ncnn4CC(F)(F)F)nc2-3)cn1 CHEMBL2381379 Ki(app) 0.14 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1ccc(-c3cnn(CC(C)(C)O)c3)cc1OCC2 CHEMBL2387079 Ki 0.14 nM
CCc1ncnc(N2CCN(S(C)(=O)=O)CC2)c1C#Cc1cnc(C)c(NS(=O)(=O)c2ccc(F)cc2)c1 CHEMBL3660111 IC50 0.14 nM
Cn1c(=O)n([C@H]2CC[C@H](O)CC2)c2c3nc(-c4ccc5[nH]ncc5c4)ccc3ncc21 CHEMBL3681182 Ki 0.145 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3cnn(CC(C)(C)O)c3)ccc1-2 CHEMBL2381374 Ki(app) 0.15 nM
O=S(=O)(Nc1cc(-c2cc3c(-c4ccncc4)ncnc3s2)cnc1Cl)c1ccc(Cl)s1 CHEMBL3577927 IC50 0.15 nM
NC(=O)[C@@H]1CCCN1c1ccc2c(c1)OCCn1cc(N3C(=O)OC[C@H]3C(F)(F)F)nc1-2 CHEMBL5202305 Ki 0.15 nM
CC[C@H](Nc1ccc2c(c1)OCCn1cc(N3C(=O)OC[C@H]3C(F)(F)F)nc1-2)C(N)=O CHEMBL5189517 Ki 0.157 nM
COc1ncc(-c2ccc3ncc(-c4cn(CCN5CCCC5)nn4)n3n2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL5413309 IC50 0.16 nM
COc1ncc(-c2ccc3ncc(-c4cn(CCCN5CCOCC5)nn4)n3n2)cc1NS(=O)(=O)c1ccc(F)cc1 CHEMBL5401298 IC50 0.16 nM
COCC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6[nH]ncc6c5)nc4c32)CC1 CHEMBL3681176 Ki 0.167 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1ccc(-c3cnn(CCO)c3)cc1OCC2 CHEMBL2387086 Ki 0.17 nM
COc1ncc(-c2ccc3ncc(-c4cn(CCN5CCN(C)CC5)nn4)n3n2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL5415726 IC50 0.17 nM
COc1ncc(-c2cc(OC3CCOCC3)c3ncnc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4527563 IC50 0.17 nM
CC(C)n1c(-c2nc3c(s2)CCOc2cc(-c4cnn(CC(C)(C)O)c4)ccc2-3)n[nH]c1=O CHEMBL2381381 Ki(app) 0.18 nM
Cc1nc(-c2nc3c(s2)CCOc2cc(-c4cnn(CCO)c4)ccc2-3)n(C(C)C)n1 CHEMBL2381378 Ki(app) 0.18 nM
C[C@H](Oc1ccc2c(c1)OCCn1cc(-c3ncnn3CC(F)(F)F)nc1-2)C(N)=O CHEMBL5171276 Ki 0.188 nM
CC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6[nH]ncc6c5)nc4c32)CC1 CHEMBL2331668 Ki 0.191 nM
COc1ccc2[nH]c(-c3c(C)nn(C)c3C)c(/C=C3/Oc4ccc(NC(=O)Nc5ccc(C(=O)N6CCOCC6)cc5)cc4C3=O)c2c1 CHEMBL1082617 IC50 0.2 nM
COc1ccc2[nH]c(-c3c(C)nn(C)c3C)c(/C=C3/Oc4ccc(NC(=O)Nc5ccc(C(=O)N6CCN(C)CC6)cc5)cc4C3=O)c2c1 CHEMBL1082618 IC50 0.2 nM
COc1cc(F)c2[nH]c(-c3c(C)nn(C)c3C)c(/C=C3/Oc4ccc(NC(=O)Nc5ccc(C(=O)N(C)CCN(C)C)cc5)cc4C3=O)c2c1 CHEMBL1082621 IC50 0.2 nM
CN(C)CCN(C)C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(O[C@H]4CCOC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL1808977 IC50 0.2 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1cnc(N(C)CC(N)=O)cc1OCC2 CHEMBL3770325 Ki(app) 0.2 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1ccc(O[C@@H](C)C(N)=O)cc1OCC2 CHEMBL3771364 Ki(app) 0.2 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOC[C@@H]2C)cc1NS(=O)(=O)c1ccccc1 CHEMBL3660114 IC50 0.2 nM
COc1ncc(-c2ccc3ncnc(Nc4cnn(CCO)c4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4780201 IC50 0.2 nM
COc1ncc(-c2ccc3ncc(-c4nnc(CCN5CCN(C)CC5)o4)n3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4440406 IC50 0.2 nM
O=S(=O)(Nc1cc(-c2cc3c(-c4ccncc4)ncnc3s2)cnc1Cl)c1ccc(F)cc1F CHEMBL3577925 IC50 0.23 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1ccc(s1)-c1ncnc3c(C)c-2sc13 CHEMBL4860369 IC50 0.23 nM
COc1ncc(-c2ccc3ncc(C(=O)NCCc4ccccc4)n3n2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL5431325 IC50 0.24 nM
COc1ncc(-c2ccc3ncc(-c4cn(CCCN5CCOCC5)nn4)n3n2)cc1NS(=O)(=O)c1ccc(Cl)cc1F CHEMBL5409142 IC50 0.24 nM
CC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccc(N)nc5)nc4c32)CC1 CHEMBL3681165 Ki 0.252 nM
CN(C)c1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)C(C)(C)O)CC2)c(=O)n4C)cn1 CHEMBL3681135 Ki 0.264 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3cnn(CCO)c3)ccc1-2 CHEMBL2381373 Ki(app) 0.27 nM
COc1ncc(-c2ccc3nncc(-c4ccncc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3577913 IC50 0.27 nM
Cn1c(=O)n([C@H]2CC[C@H](O)CC2)c2c3nc(-c4cnc(N)nc4)ccc3ncc21 CHEMBL3681154 Ki 0.273 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1ccccc1 CHEMBL3655894 IC50 0.28 nM
CN(C)c1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)C(C)(C)C)CC2)c(=O)n4C)cn1 CHEMBL3681131 Ki 0.281 nM
CN1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6[nH]ncc6c5)nc4c32)CC1 CHEMBL3681179 Ki 0.282 nM
NC(=O)[C@@H]1[C@H](F)CCN1c1ccc2c(c1)OCCn1cc(N3C(=O)OC[C@H]3C(F)(F)F)nc1-2 CHEMBL5209394 Ki 0.289 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C)c4)cc2OCC3)n(C(C)C)n1 CHEMBL2387082 Ki 0.29 nM
CN(C)c1ccc(-c2ccc3ncc4c(c3n2)n(C2CCOCC2)c(=O)n4C)cn1 CHEMBL3681130 Ki 0.298 nM
COc1ccc2[nH]c(-c3c(C)nn(C)c3C)c(/C=C3/Oc4ccc(NC(=O)Nc5ccc(C(=O)N(C)CCN(C)C)cc5)cc4C3=O)c2c1 CHEMBL1082619 IC50 0.3 nM
Cc1cc(C(=O)Nc2cnc3[nH]ccc3c2)c2nc(C)nc(N)c2c1 CHEMBL1668277 Ki 0.3 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(CCN5CCOCC5)c4)cc2OCC3)n(C(C)C)n1 CHEMBL2386972 Ki 0.3 nM
O=S(=O)(Nc1cc(-c2cc3c(-c4ccncc4)ncnc3s2)cnc1Cl)c1ccc(F)cc1 CHEMBL3577926 IC50 0.3 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1ccc(OCC(N)=O)cc1OCC2 CHEMBL3770140 Ki(app) 0.3 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1ccc(N3CCCC[C@H]3C(N)=O)cc1OCC2 CHEMBL3770717 Ki(app) 0.3 nM
COc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1ccc(Cl)cc1 CHEMBL3660127 IC50 0.3 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1ccc(-c3cn[nH]c3)cc1OCC2 CHEMBL2387081 Ki 0.31 nM
COc1ncc(-c2ccc3ncc(C(=O)NCCN4CCOCC4)n3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4213353 IC50 0.31 nM
Cc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)CN)CC2)c(=O)n4C)cn1 CHEMBL3681111 Ki 0.32 nM
Cn1c(=O)n(C2CCN(C(=O)CO)CC2)c2c3nc(-c4cnc5[nH]ncc5c4)ccc3ncc21 CHEMBL3681178 Ki 0.32 nM
NC(=O)[C@@H]1CCCN1c1ccc2c(c1)OCCn1cc(N3CCCOCC3=O)nc1-2 CHEMBL5181675 Ki 0.32 nM
NC(=O)[C@@H](Nc1ccc2c(c1)OCCn1cc(N3C(=O)OC[C@H]3C(F)(F)F)nc1-2)C1CCC1 CHEMBL5209238 Ki 0.323 nM
COc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(CC(N)=O)CC2)c(=O)n4C)cn1 CHEMBL3681082 Ki 0.339 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C5CN(C(=O)[C@H](C)O)C5)c4)cc2OCC3)n(C(C)C)n1 CHEMBL2386971 Ki 0.34 nM
N#Cc1c(N2CCOCC2)sc(-c2ncn[nH]2)c1-c1ccc(Cl)cc1Cl CHEMBL2017653 Ki 0.35 nM
NC(=O)[C@@H]1CCCN1c1ccc2c(c1)OCCn1cc(N3CC[C@H](O)C3=O)nc1-2 CHEMBL5192172 Ki 0.355 nM
Cn1c(=O)n([C@H]2CC[C@H](O)CC2)c2c3nc(-c4cnc5[nH]ncc5c4)ccc3ncc21 CHEMBL3681183 Ki 0.366 nM
COc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1ccc(Cl)s1 CHEMBL3660128 IC50 0.38 nM
COc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1cccs1 CHEMBL3660129 IC50 0.39 nM
CC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccc(N(C)C)nc5)nc4c32)CC1 CHEMBL3681121 Ki 0.391 nM
C[C@@H](O)C(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccc(N(C)C)nc5)nc4c32)CC1 CHEMBL3681140 Ki 0.397 nM
CN(C)CCNC(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL592615 IC50 0.4 nM
CN(C)C1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)nc(N5CCOCC5)n4)cc3)cc2)CC1 CHEMBL592445 IC50 0.4 nM
CN(C)CCN(C)C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL1204015 IC50 0.4 nM
CNC(=O)Nc1ccc2c(c1)C(=O)/C(=C\c1c(-c3c(C)nn(C)c3C)[nH]c3ccc(OC)cc13)O2 CHEMBL1083912 IC50 0.4 nM
CNC(=O)Nc1ccc2c(c1)C(=O)/C(=C\c1c(-c3c(C)nn(C)c3C)[nH]c3c(F)cc(OC)cc13)O2 CHEMBL1083305 IC50 0.4 nM
COc1nc(-c2ccc(NC(=O)Nc3ccc(C(=O)N(C)CCN(C)C)cc3)cc2)nc(N2CCOCC2)n1 CHEMBL1808979 IC50 0.4 nM
CS(=O)(=O)N1CCC(Cc2cc3c(N4CCOCC4)nc(-c4cnc(N)nc4)nc3s2)CC1 CHEMBL1949915 Ki(app) 0.4 nM
NC(=O)c1cn2cc(-c3cnc(N)nc3)nc(N3CCOCC3)c2n1 CHEMBL2058163 IC50 0.4 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(CCO)c4)cc2OCC3)n(C(C)C)n1 CHEMBL2387083 Ki 0.4 nM
COc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1ccccc1 CHEMBL3655855 IC50 0.4 nM
COc1ncc(-c2ccc3ncnc(NC4CCN(C(C)=O)CC4)c3c2)cc1NS(C)(=O)=O CHEMBL4515169 IC50 0.4 nM
O=C1NC(=O)/C(=C/c2ccc3nccc(-c4ccncc4)c3c2)S1 CHEMBL3544966 IC50 0.4 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1ccc(F)cc1 CHEMBL3655884 IC50 0.43 nM
CO/C=C/C(=O)c1cc2c3c(c(N)cc(NC(=O)C(C)C)c3n1)N=C2 CHEMBL4293970 Kd 0.43 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCCn1cc(cn1)-c1ncnc3c(C)c-2sc13 CHEMBL4876895 IC50 0.43 nM
C[C@H](CO)n1c(=O)n(C)c2cnc3ccc(-c4c[nH]c5nncc-5c4)nc3c21 CHEMBL3681162 Ki 0.438 nM
COc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3655883 IC50 0.44 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1ccnn1C CHEMBL3660101 IC50 0.44 nM
COc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1ccccc1C(F)(F)F CHEMBL3660126 IC50 0.44 nM
NC(=O)[C@@H]1CCCN1c1ccc2c(c1)OCCn1cc(N3CCn4nccc4C3=O)nc1-2 CHEMBL5204346 Ki 0.44 nM
COc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1ccnn1C CHEMBL3660130 IC50 0.45 nM
Cc1ncnc(N2CCOCC2)c1C#Cc1cncc(NS(=O)(=O)c2ccccc2)c1 CHEMBL3655873 IC50 0.46 nM
Cc1ncnc(N2CCOCC2)c1C#Cc1cncc(NS(=O)(=O)c2ccc(F)cc2F)c1 CHEMBL3655874 IC50 0.46 nM
COc1ccc(C(=O)NNC(=O)c2cc3nc(-c4cnc(N)nc4)nc(N4CCOCC4)c3s2)cc1 CHEMBL5278435 IC50 0.46 nM
COc1ncc(-c2ccc3ncc(-c4cn(CCCN5CCOCC5)nn4)n3n2)cc1NS(=O)(=O)c1ccc(CC(F)(F)F)cc1 CHEMBL5428160 IC50 0.46 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CN(C(C)(C)C(N)=O)C3)ccc1-2 CHEMBL2381279 Ki(app) 0.47 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1ccc(Cl)s1 CHEMBL3655906 IC50 0.47 nM
CCc1ncnc(N2CCN(C(C)=O)CC2)c1C#Cc1cnc(C)c(NS(=O)(=O)c2ccc(F)cc2)c1 CHEMBL3660112 IC50 0.47 nM
COc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(C)=O)CC2)c(=O)n4C)cn1 CHEMBL2331661 Ki 0.478 nM
CCc1ncnc(N2CCC(O)CC2)c1C#Cc1cnc(C)c(NS(=O)(=O)c2ccc(F)cc2)c1 CHEMBL3660110 IC50 0.48 nM
Cc1nc(N)nc2c1cc(-c1cnc3[nH]ccc3c1)c(=O)n2C1CCCC1 CHEMBL3648918 IC50 0.48 nM
CN1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)nc(N5CCOCC5)n4)cc3)cc2)CC1 CHEMBL1204014 IC50 0.5 nM
COc1ccc2[nH]c(-c3c(C)nn(C)c3C)c(/C=C3/Oc4ccc(NC(=O)Nc5cccnc5)cc4C3=O)c2c1 CHEMBL1082986 IC50 0.5 nM
COc1cc(F)c2[nH]c(-c3c(C)nn(C)c3C)c(/C=C3/Oc4ccc(NC(=O)Nc5ccc(C(=O)N6CCOCC6)cc5)cc4C3=O)c2c1 CHEMBL1082620 IC50 0.5 nM
COc1ccc(NC(=O)c2cc(C)cc3c(N)nc(C)nc23)cn1 CHEMBL1668264 Ki 0.5 nM
Cc1ccc(NC(=O)c2cccc3c(N)nc(C)nc23)cn1 CHEMBL1668269 Ki 0.5 nM
Cc1cc(C(=O)Nc2ccc(C)nc2)c2nc(C)nc(N)c2c1 CHEMBL1668271 Ki 0.5 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnn2ccc(C#N)cc12 CHEMBL1928541 IC50 0.5 nM
CCN(/N=C/c1cnn2ccc(C#N)cc12)S(=O)(=O)c1cc([N+](=O)[O-])ccc1C CHEMBL1928555 IC50 0.5 nM
CN(/N=C/c1cnn2ccc(C#N)cc12)S(=O)(=O)c1cc([N+](=O)[O-])ccc1Cl CHEMBL1928725 IC50 0.5 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnc2ccc(Br)cn12 CHEMBL393525 IC50 0.5 nM
CC[C@H](Oc1ccc2c(c1)OCCn1cc(-c3ncnn3C(C)C)nc1-2)C(N)=O CHEMBL3769854 Ki(app) 0.5 nM
COc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1ccccc1OC(F)(F)F CHEMBL3660125 IC50 0.5 nM
COc1ccc(-c2ccc3ncc4c(c3n2)n([C@H]2CC[C@H](OCCO)CC2)c(=O)n4C)cn1 CHEMBL2331658 Ki 0.5 nM
COc1ccc(-c2ccc3ncc4c(c3n2)n([C@H]2CC[C@H](O)CC2)c(=O)n4C)cn1 CHEMBL2331659 Ki 0.5 nM
CN(C)c1ccc(-c2ccc3ncc4c(c3n2)n(C2CCNCC2)c(=O)n4C)cn1 CHEMBL3681119 Ki 0.5 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCN(C(C)=O)C4)c3c2)cc1NS(C)(=O)=O CHEMBL4449091 IC50 0.5 nM
COc1ncc(-c2ccc3ncc(NC(=O)N4CCC[C@H]4C(N)=O)c(=O)n3c2)cc1NS(=O)(=O)c1ccc(F)cc1Cl CHEMBL4641635 IC50 0.5 nM
CNC(=O)[C@H](C)Cn1cnc2ccc(-c3cnc(OC)c(NS(=O)(=O)c4sc(C)nc4C)c3)cc2c1=O CHEMBL4640081 IC50 0.5 nM
CN(C)c1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)CO)CC2)c(=O)n4C)cn1 CHEMBL3681142 Ki 0.505 nM
Cc1ncnc(N2CCOCC2)c1C#Cc1c[nH]c(=O)c(NS(=O)(=O)c2ccc(F)cc2F)c1 CHEMBL3655895 IC50 0.51 nM
COc1ccc(-c2ccc3ncc4[nH]c(=O)n([C@H]5CC[C@H](O)CC5)c4c3n2)cn1 CHEMBL3681079 Ki 0.51 nM
NC(=O)c1cccc2cc(C(=O)N3CCN(Cc4cc5nc(-c6cnc(N)nc6)nc(N6CCOCC6)c5o4)CC3)oc12 CHEMBL4868231 IC50 0.51 nM
CC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cccc6[nH]ncc56)nc4c32)CC1 CHEMBL2331667 Ki 0.513 nM
Cn1c(=O)n(C2CCOCC2)c2c3nc(-c4cnc(N)nc4)ccc3ncc21 CHEMBL3681136 Ki 0.529 nM
Cc1ncnc(N2CCOCC2)c1C#Cc1cncc(NS(=O)(=O)c2cccs2)c1 CHEMBL3655875 IC50 0.53 nM
COc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1ccc(C)o1 CHEMBL3660132 IC50 0.53 nM
Cc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)CO)CC2)c(=O)n4C)cn1 CHEMBL2331663 Ki 0.532 nM
CCC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6ccccc6c5)nc4c32)CC1 CHEMBL3681068 Ki 0.539 nM
CCc1ncnc(N2CCC(C)(O)CC2)c1C#Cc1cnc(C)c(NS(C)(=O)=O)c1 CHEMBL3655896 IC50 0.55 nM
Cc1cc(S(=O)(=O)Nc2cc(C#Cc3c(C)ncnc3N3CCOCC3)cnc2C)c(C)s1 CHEMBL3655902 IC50 0.55 nM
CCc1ncnc(N2CCOCC2)c1C#Cc1cnc(OC)c(NS(=O)(=O)c2ccco2)c1 CHEMBL3660123 IC50 0.55 nM
COc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1cnn(C)c1 CHEMBL3660131 IC50 0.55 nM
CCOc1cnc(CN2CCC(n3cc4cc(C(=O)N5CCN(Cc6ccc(C(F)(F)F)cc6)CC5)ccc4n3)CC2)cn1 CHEMBL3969654 IC50 0.55 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1cnn(C)c1 CHEMBL3655905 IC50 0.56 nM
C[C@@H]1COC(=O)N1c1cn2c(n1)-c1ccc(N3CCC[C@H]3C(N)=O)cc1OCC2 CHEMBL5194906 Ki 0.56 nM
Cn1c(=O)n(C2CCN(C(=O)C(C)(C)O)CC2)c2c3nc(-c4cnc5ccccc5c4)ccc3ncc21 CHEMBL3681086 Ki 0.568 nM
COc1ccc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@H](OCCO)CC3)c2=O)cn1 CHEMBL1234354 Ki 0.57 nM
COc1ccc(C2=CC3C(C)=NC(N)=NC3N([C@H]3CC[C@H](OCCO)CC3)C2=O)cn1 CHEMBL3218579 Ki 0.57 nM
Cn1c(=O)n(C2CCN(C(=O)CO)CC2)c2c3nc(-c4cccc5[nH]ncc45)ccc3ncc21 CHEMBL3681174 Ki 0.575 nM
COc1cc(CN(c2cc(-c3cc(OC4CCOCC4)c4ncnc(C)c4c3)cnc2OC)S(=O)(=O)c2ccc(F)cc2F)c([N+](=O)[O-])cc1OC CHEMBL5094345 IC50 0.58 nM
COc1ncc(-c2ccc3nccc(-c4ccc(CN(C)CCO)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3905146 IC50 0.59 nM
CCc1ncnc(N2CCOCC2)c1C#Cc1cnc(OC)c(NS(=O)(=O)c2ccccc2)c1 CHEMBL3655880 IC50 0.59 nM
O=C(Nc1ccc(C(=O)N2CCC(N3CCCCC3)CC2)cc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1 CHEMBL592619 IC50 0.6 nM
Cc1nc(N)nc(-n2c(Nc3cc(O)cc(O)c3)nc3ccccc32)n1 CHEMBL1762790 IC50 0.6 nM
O=S(=O)(Nc1cncc(-c2ccc3ncc(-c4nn[nH]n4)n3c2)c1)c1ccc(F)cc1F CHEMBL1765627 IC50 0.6 nM
CN(C(=O)c1cc2c(s1)-c1ccc(-c3cn[nH]c3)cc1OCC2)c1ccccc1Cl CHEMBL1796757 Ki 0.6 nM
COc1nc(-c2ccc(NC(=O)Nc3ccc(C(=O)NCCN(C)C)cc3)cc2)nc(N2CCOCC2)n1 CHEMBL1808980 IC50 0.6 nM
CN1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(OC5COC5)nc(N5CCOCC5)n4)cc3)cc2)CC1 CHEMBL1808984 IC50 0.6 nM
O=S(=O)(Nc1cc(-c2ccc3ncc(N4CCC(F)(F)CC4)nc3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914739 Ki 0.6 nM
O=S(=O)(Nc1cc(-c2ccc3nccc(N4CCOCC4)c3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1738719 Ki 0.6 nM
N#Cc1ccc(-c2c(-c3ncn[nH]3)sc(N3CCOCC3)c2C#N)c(F)c1 CHEMBL2017654 Ki 0.6 nM
CN(C)CCCNC(=O)c1cn2cc(-c3cnc(N)nc3)nc(N3CCOCC3)c2n1 CHEMBL2058165 IC50 0.6 nM
COc1ncc(-c2cc(OCCCCC(=O)NO)c3ncnc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4445101 IC50 0.6 nM
CNC(=O)C(C)Cn1cnc2ccc(-c3cnc(C(F)(F)F)c(NS(=O)(=O)c4ccc(F)cc4Cl)c3)cc2c1=O CHEMBL4644237 IC50 0.6 nM
NC(=O)c1cccc2cc(C(=O)N3CCN(Cc4cc5nc(-c6cnc(N)nc6)nc(N6CCOCC6)c5s4)CC3)oc12 CHEMBL4871210 IC50 0.6 nM
NC(=O)[C@H]1CCCN1C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL5091789 IC50 0.6 nM
NC(=O)C1CCCN1C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL5074018 IC50 0.6 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CN(C(=O)CO)C3)ccc1-2 CHEMBL2381277 Ki(app) 0.61 nM
Cc1c(CN2CCN(C(=O)[C@H](C)O)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1922094 Kd 0.62 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1ccccc1C(F)(F)F CHEMBL3655867 IC50 0.63 nM
CCc1ncnc(N2CCOCC2)c1C#Cc1cnc(OC)c(NS(=O)(=O)c2ccc(F)cc2F)c1 CHEMBL3655879 IC50 0.63 nM
COc1ncc(-c2cc(OCCCCCCCC(=O)NO)c3ncnc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4581165 IC50 0.63 nM
COc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(C)(=O)=O CHEMBL3660124 IC50 0.64 nM
COc1ccc(-c2ccc3ncc4[nH]c(=O)n([C@H]5CC[C@H](OCCO)CC5)c4c3n2)cn1 CHEMBL3681078 Ki 0.644 nM
COc1ncc(-c2ccc3nccc(-c4ccc(Cn5cncn5)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3968925 IC50 0.65 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1ccccc1F CHEMBL3655856 IC50 0.65 nM
COc1ccc(CN2CCC(n3cc4cc(C(=O)N5CCN(Cc6ccc(C(F)(F)F)cc6)CC5)ccc4n3)CC2)cn1 CHEMBL3970694 IC50 0.65 nM
COc1ncc(-c2ccc3ncc(-c4cn(CCCN5CCOCC5)nn4)n3n2)cc1NS(=O)(=O)c1ccccc1 CHEMBL5440536 IC50 0.65 nM
Cc1ncnc(N2CCOCC2)c1C#Cc1cncc(NS(=O)(=O)c2cnn(C)c2)c1 CHEMBL3655877 IC50 0.66 nM
COc1ncc(-c2cc(OCCCCCC(=O)NO)c3ncnc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4527487 IC50 0.66 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NC[C@@H]1CN(CCO1)c1ncnc3c(C)c-2sc13 CHEMBL4869487 IC50 0.66 nM
COc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCOCC2)c(=O)n4C)cn1 CHEMBL3681083 Ki 0.668 nM
CC1(C)C(=O)NC(=O)N1c1cn2c(n1)-c1ccc(N3CCC[C@H]3C(N)=O)cc1OCC2 CHEMBL5184370 Ki 0.681 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@H](OCC(N)=O)CC3)c2=O)cc1F CHEMBL2375957 IC50 0.686 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CN(C[C@H](O)CO)C3)ccc1-2 CHEMBL2381275 Ki(app) 0.69 nM
CN(C)Cc1ccc(-c2ccnc3ccc(-c4cnc(Cl)c(NS(=O)(=O)c5ccc(F)cc5F)c4)cc23)cc1 CHEMBL3896198 IC50 0.69 nM
COc1ncc(-c2cc(OCCCCCCC(=O)NO)c3ncnc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4435527 IC50 0.69 nM
CC(C)[C@H](Nc1ccc2c(c1)OCCn1cc(N3C(=O)OC[C@H]3C(F)(F)F)nc1-2)C(N)=O CHEMBL5186223 Ki 0.692 nM
O=C(Nc1ccc(C(=O)N2CCC(N3CCCC3)CC2)cc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1 CHEMBL592461 IC50 0.7 nM
CN(C)c1ccc(-c2ccnc3ccc(-c4cnc(Cl)c(NS(=O)(=O)c5ccc(F)cc5)c4)cc23)cc1 CHEMBL1914728 Ki 0.7 nM
O=S(=O)(Nc1cc(-c2ccc3nccc(-c4cccnc4)c3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914726 Ki 0.7 nM
Cc1c(CN2CCN(C(=O)CN)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1922090 IC50 0.7 nM
COc1ncc(-c2cc(OC(C)C)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4174456 IC50 0.7 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCN(C(=O)C5CCOCC5)C4)c3c2)cc1NS(C)(=O)=O CHEMBL4542688 IC50 0.7 nM
NC(=O)[C@@H]1CCCN1C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL5071942 IC50 0.7 nM
NC(=O)C1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)nc(N5CCOCC5)n4)cc3)cc2)CC1 CHEMBL5076528 IC50 0.7 nM
COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCN(C(=S)SCC(=O)N3CCOCC3)CC2)n1 CHEMBL5419197 IC50 0.7 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(-c4ccc(N5CCOCC5)nc4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4872728 IC50 0.709 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(-c4ccncc4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4864419 IC50 0.71 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(-c4ccc(N5CCOCC5)cc4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4853440 IC50 0.711 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1cccs1 CHEMBL3655864 IC50 0.72 nM
C[C@H](O)C(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cccc6[nH]ncc56)nc4c32)CC1 CHEMBL2331669 Ki 0.721 nM
O=S(=O)(Nc1cc(-c2ccc3nccc(-c4ccc(Cn5cncn5)cc4)c3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL3958024 IC50 0.73 nM
COc1ncc(-c2cc(OCC3CCOCC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4165063 IC50 0.73 nM
CNc1nc(C)c2cc(-c3cccc(O)c3)c(=O)n(C3CCCC3)c2n1 CHEMBL3648932 IC50 0.731 nM
Cc1ncc(C#Cc2c(C)ncnc2N(C)C(C)C)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3655869 IC50 0.74 nM
CN(CCO)Cc1ccc(-c2ccnc3ccc(-c4cnc(Cl)c(NS(=O)(=O)c5ccc(F)cc5F)c4)cc23)cc1 CHEMBL3975939 IC50 0.75 nM
CCc1ncnc(N2CCOCC2)c1C#Cc1cnc(OC)c(NS(=O)(=O)c2cccs2)c1 CHEMBL3660122 IC50 0.75 nM
CNc1nc(C)c2cc(-c3cnc4[nH]ccc4c3)c(=O)n(C3CCCC3)c2n1 CHEMBL3648913 IC50 0.75 nM
CNC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccc(N(C)C)nc5)nc4c32)CC1 CHEMBL3681122 Ki 0.76 nM
CCNc1nc(C)c2cc(-c3cnc(OC)c(F)c3)c(=O)n([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL3652248 IC50 0.788 nM
CC(=O)N1CCN(c2ncnc(C)c2C#Cc2cnc(C)c(NS(=O)(=O)c3ccc(F)cc3F)c2)CC1 CHEMBL3655871 IC50 0.79 nM
COc1cc2c(cc1Nc1nc(Nc3cccc4c3C(=O)NC4)c3cc[nH]c3n1)N(C(=O)CN(C)C)CC2 CHEMBL517163 IC50 0.8 nM
CCn1ccc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)N5CCNCC5)cc4)cc3)nc21 CHEMBL1092404 IC50 0.8 nM
CCOC(=O)c1cnc2ccc(-c3cncc(NS(=O)(=O)c4ccccc4)c3)cn12 CHEMBL1765463 IC50 0.8 nM
O=S(=O)(Nc1cncc(-c2ccc3ncc(-c4nn[nH]n4)n3c2)c1)c1ccccc1 CHEMBL1765617 IC50 0.8 nM
CNCCN(C)C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(OC)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL1808981 IC50 0.8 nM
O=S(=O)(Nc1cc(-c2ccc3ncc(NCCc4ccccc4)nc3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914734 Ki 0.8 nM
CC(C)N1CCN(c2cnc3ccc(-c4cnc(Cl)c(NS(=O)(=O)c5ccc(F)cc5)c4)cc3n2)CC1 CHEMBL1914742 Ki 0.8 nM
O=S(=O)(Nc1cc(-c2ccc3nccc(-c4ccncc4)c3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914727 Ki 0.8 nM
O=S(=O)(Nc1cc(-c2ccc3ncc(NCC4CCCCC4)nc3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914731 Ki 0.8 nM
O=S(=O)(Nc1cc(-c2ccc3ncc(N4CCOCC4)nc3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914743 Ki 0.8 nM
COc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnn2ccc(C#N)cc12 CHEMBL1928726 IC50 0.8 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(CCO)/N=C/c1cnn2ccc(C#N)cc12 CHEMBL1928561 IC50 0.8 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1c(F)cccc1F CHEMBL3655861 IC50 0.8 nM
Cc1ncnc(N2CCOCC2)c1C#Cc1cncc(NS(=O)(=O)c2cccnc2)c1 CHEMBL3655876 IC50 0.8 nM
COc1ncc(-c2cc(OC3CCOCC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4166144 IC50 0.8 nM
COc1ncc(-c2ccc3nccc(/C(C)=C/C(=O)N4CCN(C)CC4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4739883 IC50 0.8 nM
COc1ncc2cc1NS(=O)(=O)c1cc(c(F)cc1F)C(=O)NCc1cncc(c1)-c1ccnc3ccc-2cc13 CHEMBL4868571 IC50 0.8 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1cncc(c1)-c1cnc3ccc-2cn13 CHEMBL4864407 IC50 0.8 nM
NC(=O)[C@@H]1CCCN1c1ccc2c(c1)OCCn1cc(N3C(=O)CC[C@H]3C(F)(F)F)nc1-2 CHEMBL5185638 Ki 0.8 nM
COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCN(C(=S)SCC(=O)N(C)C)CC2)n1 CHEMBL5431418 IC50 0.8 nM
COCCN1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccc(N(C)C)nc5)nc4c32)CC1 CHEMBL3681132 Ki 0.802 nM
COC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6ccccc6c5)nc4c32)CC1 CHEMBL3681069 Ki 0.806 nM
CC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccnc6[nH]ncc56)nc4c32)CC1 CHEMBL3681171 Ki 0.811 nM
O=S(=O)(Nc1cc(-c2ccc3nccc(-c4ccc(Cn5cncn5)cc4)c3c2)cnc1Cl)c1ccc(F)cc1F CHEMBL3897883 IC50 0.82 nM
COCCN1CCN(c2ncnc(C)c2C#Cc2cnc(C)c(NS(=O)(=O)c3ccccc3)c2)CC1 CHEMBL3660102 IC50 0.83 nM
COc1ncc(-c2cc(O[C@H]3CCOC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4169573 IC50 0.83 nM
Cn1c(=O)n(C2CCN(C(=O)CO)CC2)c2c3nc(-c4ccnc5[nH]ncc45)ccc3ncc21 CHEMBL3681172 Ki 0.832 nM
C[C@H]1COCCN1c1nc(-c2cnc(N)cc2C(F)F)nc(N2CCOCC2)n1 CHEMBL4453693 Kd 0.84 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCCCC2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3655868 IC50 0.85 nM
C[C@H](Oc1ccc2c(c1)OCCn1cc(N3C(=O)OC[C@H]3C(F)F)nc1-2)C(N)=O CHEMBL5202964 Ki 0.853 nM
Cc1ncc(C#Cc2c(C)ncnc2N(C)C2CCOCC2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3655870 IC50 0.86 nM
CCc1ncnc(N2CCC(O)CC2)c1C#Cc1cnc(C)c(NS(C)(=O)=O)c1 CHEMBL3655900 IC50 0.86 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@H](OCCO)CC3)c2=O)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4166142 IC50 0.87 nM
Cc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(CC(N)=O)CC2)c(=O)n4C)cn1 CHEMBL3681108 Ki 0.882 nM
CCc1ncnc(N2CCN(C)CC2)c1C#Cc1cnc(C)c(NS(=O)(=O)c2ccc(F)cc2)c1 CHEMBL3660109 IC50 0.89 nM
CN(C)CCN(C)C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)c4ccn(CC(F)(F)F)c4n3)cc2)cc1 CHEMBL1092072 IC50 0.9 nM
COc1ccc2[nH]cc(/C=C3/Oc4ccc(NC(=O)Nc5ccc(C(=O)N6CCN(C)CC6)cc5)cc4C3=O)c2c1 CHEMBL1082622 IC50 0.9 nM
O=S(=O)(Nc1cc(-c2ccc3nccc(N4CCN(Cc5ccncc5)CC4)c3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914724 Ki 0.9 nM
COCCNc1cnc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)cc2n1 CHEMBL1914729 Ki 0.9 nM
O=S(=O)(Nc1cc(-c2ccc3ncc(N4CCCCC4)nc3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914738 Ki 0.9 nM
O=S(=O)(Nc1cc(-c2ccc3nccc(N4CCC(O)CC4)c3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914721 Ki 0.9 nM
COCCNC(=O)c1nc2c(N3CCOCC3)nc(-c3cnc(N)nc3)cn2c1C CHEMBL2058172 IC50 0.9 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CN(CC(C)(C)O)C3)ccc1-2 CHEMBL2381276 Ki(app) 0.9 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1cnc(OCC(N)=O)cc1OCC2 CHEMBL3769966 Ki(app) 0.9 nM
COc1ncc(-c2ccc3ncnc(NC4CCNCC4)c3c2)cc1NS(C)(=O)=O CHEMBL4461362 IC50 0.9 nM
COc1ncc(-c2cc(OCCCCCCCCC(=O)NO)c3ncnc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4465475 IC50 0.9 nM
C[C@@H](NC(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1)C(N)=O CHEMBL5093540 IC50 0.9 nM
COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCN(C(=S)SCC(=O)N3CCCC3)CC2)n1 CHEMBL5410806 IC50 0.9 nM
COc1ncc(-c2ccc3nccc(-c4ccc(Cn5cncn5)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1 CHEMBL3986709 IC50 0.91 nM
COCC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccc(C)nc5)nc4c32)CC1 CHEMBL2331666 Ki 0.922 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(-c4cnc(N5CCOCC5)nc4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4871838 IC50 0.936 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CN(C(=O)C(C)(C)N)C3)ccc1-2 CHEMBL2381278 Ki(app) 0.94 nM
COc1cc(N)cc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL1911117 IC50 0.95 nM
COc1ncc(-c2ccc3nccc(-c4ccc(Cn5ccnc5C)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3985009 IC50 0.95 nM
COc1ncc(-c2cc(OC3CCCCC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4162701 IC50 0.95 nM
COc1ncc(-c2cc(OC3CCC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4168480 IC50 0.95 nM
CNc1nc(C)c2cc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4F)c3)cc(O[C@@H]3CCOC3)c2n1 CHEMBL4174909 IC50 0.96 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1cc(F)cc(F)c1 CHEMBL3655885 IC50 0.97 nM
COc1ncc(-c2ccc3ncc4c(c3n2)n([C@H]2CC[C@H](O)CC2)c(=O)n4C)cn1 CHEMBL3681104 Ki 0.974 nM
COc1cc(-c2cc3c(C)nc(N)nc3n(C3CCCC3)c2=O)ccc1O CHEMBL3648924 IC50 0.989 nM
COc1ncc(-c2ccc3ncc(-c4cn(CCCN5CCCC5)nn4)n3n2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL5415865 IC50 0.99 nM
COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C(C3=O)[C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O CHEMBL428496 IC50 1.0 nM
C[C@@]12c3ccc4c(c3C(=O)c3occ(c31)C(=O)C[C@H]2O)CCC4=O CHEMBL549959 IC50 1.0 nM
O=C(Nc1ccc(CO)cc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1 CHEMBL597004 IC50 1.0 nM
CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)NCCN(C)C)cc4)cc3)nc21 CHEMBL590587 IC50 1.0 nM
CN(Cc1cc2nc(-c3cnc(N)nc3)nc(N3CCOCC3)c2s1)S(C)(=O)=O CHEMBL1090598 IC50 1.0 nM
CN1CCN(C(=O)c2cccc(-c3cc4nc(-c5cnc(N)nc5)nc(N5CCOCC5)c4s3)c2)CC1 CHEMBL1090239 IC50 1.0 nM
COc1ccc2[nH]c(-c3cccnc3)c(/C=C3\Oc4cc(O)cc(O)c4C3=O)c2c1 CHEMBL1093445 IC50 1.0 nM
COc1cc(F)c2[nH]c(-c3c(C)nn(C)c3C)c(/C=C3/Oc4ccc(NC(=O)Nc5cccnc5)cc4C3=O)c2c1 CHEMBL1082616 IC50 1.0 nM
Cc1nc(N)c2cccc(C(=O)Nc3cnc4[nH]ccc4c3)c2n1 CHEMBL1668275 Ki 1.0 nM
CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)N5CCN(C)CC5)cc4)cc3)nc21 CHEMBL589258 IC50 1.0 nM
CC(C)Oc1nc(-c2ccc(NC(=O)Nc3ccc(C(=O)N(C)CCN(C)C)cc3)cc2)nc(N2CCOCC2)n1 CHEMBL1808986 IC50 1.0 nM
CN(C)C1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(O[C@H]5CCOC5)nc(N5CCOCC5)n4)cc3)cc2)CC1 CHEMBL1808988 IC50 1.0 nM
O=S(=O)(Nc1cc(-c2ccc3ncc(N4C[C@H]5CC[C@H](CC5)C4)nc3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914740 Ki 1.0 nM
O=S(=O)(Nc1cc(-c2ccc3nccc(N4CCN(Cc5ccccc5)CC4)c3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914723 Ki 1.0 nM
COCCN(C)c1cnc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)cc2n1 CHEMBL1914730 Ki 1.0 nM
O=S(=O)(Nc1cc(-c2ccc3ncc(-c4ccncc4)nc3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914947 Ki 1.0 nM
Cc1c(CN2CCN(C(=O)C(C)(C)N)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1922092 IC50 1.0 nM
CS(=O)(=O)N1CCN(Cc2cc3c(N4CCOCC4)nc(-c4cnc(N)nc4)nc3s2)CC1 CHEMBL1949910 Ki(app) 1.0 nM
CS(=O)(=O)C1CCN(Cc2cc3c(N4CCOCC4)nc(-c4cnc(N)nc4)nc3s2)CC1 CHEMBL1949916 Ki(app) 1.0 nM
CS(=O)(=O)c1cccc(-c2cc3c(N4CCOCC4)nc(-c4cnc(N)nc4)nc3s2)c1 CHEMBL1949919 Ki(app) 1.0 nM
CC(=O)Nc1ccc2c(c1)OCCc1cc(C(=O)N(C)c3ccccc3Cl)sc1-2 CHEMBL1796273 Ki(app) 1.0 nM
CNC(=O)c1ccc2c(c1)OCCc1cc(C(=O)N(C)c3ccccc3Cl)sc1-2 CHEMBL1796276 Ki(app) 1.0 nM
CN(C(=O)c1cc2c(s1)-c1cc(C(N)=O)ccc1OCC2)c1ccccc1Cl CHEMBL1950034 Ki(app) 1.0 nM
CCNC(=O)c1ccc2c(c1)-c1sc(C(=O)N(C)c3ccccc3Cl)cc1CCO2 CHEMBL1950035 Ki(app) 1.0 nM
NC(=O)c1ccc2c(c1)OCCc1cc(-c3n[nH]cc3-c3ccccc3Cl)sc1-2 CHEMBL2322780 IC50 1.0 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1cnc(O[C@@H](C)C(N)=O)cc1OCC2 CHEMBL3770824 Ki(app) 1.0 nM
COC(=O)Nc1ccc2c(c1)OCCc1cc(-c3nncn3-c3ccccc3Cl)sc1-2 CHEMBL3770332 Ki(app) 1.0 nM
COC(C)(C)c1cc2nc(-c3cnc(N)nc3)nc(N3CCOCC3)c2s1 CHEMBL2178606 Ki(app) 1.0 nM
CN(CCO)Cc1ccc(-c2ccnc3ccc(-c4cnc(Cl)c(NS(=O)(=O)c5ccc(F)cc5)c4)cc23)cc1 CHEMBL3939972 IC50 1.0 nM
COc1cccc(S(=O)(=O)Nc2cc(C#Cc3c(C)ncnc3N3CCOCC3)cnc2C)c1 CHEMBL3655858 IC50 1.0 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1ccccc1Cl CHEMBL3655859 IC50 1.0 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1cccc(F)c1 CHEMBL3655860 IC50 1.0 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1ccccc1Br CHEMBL3655862 IC50 1.0 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1cn(C)cn1 CHEMBL3655863 IC50 1.0 nM
Cc1ccccc1S(=O)(=O)Nc1cc(C#Cc2c(C)ncnc2N2CCOCC2)cnc1C CHEMBL3655865 IC50 1.0 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCN(C)CC2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3655872 IC50 1.0 nM
CCc1ncnc(N(C)C)c1C#Cc1cnc(C)c(NS(=O)(=O)c2ccc(F)cc2)c1 CHEMBL3655881 IC50 1.0 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(C)(=O)=O CHEMBL3655891 IC50 1.0 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1ccoc1 CHEMBL3655904 IC50 1.0 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1cccnc1 CHEMBL3660099 IC50 1.0 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1cn(C)c(C)n1 CHEMBL3660100 IC50 1.0 nM
CCc1ncnc(N2CCOCC2)c1C#Cc1cnc(OC)c(NS(C)(=O)=O)c1 CHEMBL3660118 IC50 1.0 nM
CCc1ncnc(N2CCOCC2)c1C#Cc1cnc(OC)c(NS(=O)(=O)C2CC2)c1 CHEMBL3660120 IC50 1.0 nM
O=S(=O)(Nc1cc(-c2cnc3ccc(-c4cccnc4)cn23)cnc1Cl)c1ccc(F)cc1 CHEMBL3649428 Ki 1.0 nM
CN(C)S(=O)(=O)Nc1cc(-c2cnc3ccc(-c4ccncc4)cn23)cnc1Cl CHEMBL3649445 Ki 1.0 nM
CN(C)S(=O)(=O)Nc1cc(-c2cnc3ccc(-c4ccnc(C(F)(F)F)c4)cn23)cnc1Cl CHEMBL3649436 Ki 1.0 nM
COc1ncc(Nc2ncc(C(C)c3ccc(S(C)(=O)=O)cc3)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL3646485 Ki 1.0 nM
COc1ncc(Nc2ncc([C@@H](C)N3CCN(S(C)(=O)=O)C[C@@H]3C)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL2170088 Ki 1.0 nM
COc1ncc(Nc2ncc([C@@H](C)N3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc3[nH]cnc23)cc1F CHEMBL3646588 Ki 1.0 nM
COc1ncc(Nc2ncc([C@@H](C)N3CCN(S(C)(=O)=O)C[C@@H]3C)cc2-c2cc(N)nc(C)n2)cc1F CHEMBL3646596 Ki 1.0 nM
COc1ncc(-c2cc(O[C@@H]3CCOC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4176771 IC50 1.0 nM
COc1ncc(-c2cc(OC3CCOC(C)(C)C3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4172954 IC50 1.0 nM
COc1ncc(-c2cc3c(C)nc(NC(C)=O)nc3s2)cc1NS(=O)(=O)c1ccc(Cl)s1 CHEMBL4225483 IC50 1.0 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCN(C(=O)C5CC5)C4)c3c2)cc1NS(C)(=O)=O CHEMBL4471468 IC50 1.0 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1cccc(c1)Cc1cnc3sc-2nn13 CHEMBL4853785 IC50 1.0 nM
CCNc1nc(C)c2cc(-c3cccc(O)c3)c(=O)n(C3CCCC3)c2n1 CHEMBL3648930 IC50 1.01 nM
COc1ncc(-c2cc3c(-c4ccncc4)ccnc3cn2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3577910 IC50 1.02 nM
CNc1nc(C)c2cc(-c3ccc(OC)nc3)c(=O)n(C3CCCC3)c2n1 CHEMBL3218401 IC50 1.03 nM
Cc1ccc(-c2ccc3ncc4c(c3n2)n([C@H]2CC[C@H](O)CC2)c(=O)n4C)cn1 CHEMBL3681110 Ki 1.03 nM
C[C@H](O)C(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccnc6[nH]ncc56)nc4c32)CC1 CHEMBL3681173 Ki 1.04 nM
COc1ncc(-c2ccc3nccc(/C=C/C(=O)N4CCN(C)CC4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4789813 IC50 1.04 nM
Cc1ccc(S(C)(=O)=O)c(-c2nc3cc(F)cc(F)c3c(N3CC(C)(C)c4ncc(N5CCOCC5)cc43)c2C)c1 CHEMBL2216891 Ki 1.05 nM
CN(C)c1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(N)=O)CC2)c(=O)n4C)cn1 CHEMBL3681123 Ki 1.05 nM
CC(C)C(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6ccccc6c5)nc4c32)CC1 CHEMBL3681072 Ki 1.06 nM
Cn1c(=O)n([C@H]2CC[C@H](OCCO)CC2)c2c3nc(-c4cnc5ccccc5c4)ccc3ncc21 CHEMBL3681090 Ki 1.08 nM
COc1ncc(-c2ccc3ncc(-c4cn(CCCN5CCOCC5)nn4)n3n2)cc1NS(C)(=O)=O CHEMBL5432324 IC50 1.09 nM
Cc1nc(N)ncc1-c1nc(N2CCOCC2)c2sc(CN3CCN(S(C)(=O)=O)CC3)cc2n1 CHEMBL1085177 IC50 1.1 nM
Cn1ncc2c(NCC(C)(C)CO)nc(-c3cccc4[nH]ncc34)nc21 CHEMBL1257419 IC50 1.1 nM
CC(=O)Nc1nc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4cccc(F)c4)c3)cc2s1 CHEMBL1773736 Ki 1.1 nM
CCN(CC)Cc1ccc(-c2ccnc3ccc(-c4cnc(OC)c(NS(=O)(=O)c5ccc(F)cc5F)c4)cc23)cc1 CHEMBL3915419 IC50 1.1 nM
COc1ncc(-c2ccc3nccc(-c4ccc(Cn5cccn5)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3976938 IC50 1.1 nM
COc1ncc(-c2ccc3nccc(-c4ccc(Cn5ccnc5)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3904493 IC50 1.1 nM
O=S(=O)(Nc1cc(-c2ccc3nccc(-c4ccc(CN5CCOCC5)cc4)c3c2)cnc1N1CCOCC1)c1ccc(F)cc1F CHEMBL3949358 IC50 1.1 nM
O=S(=O)(Nc1cc(-c2ccc3nccc(-c4ccc(CN5CCOCC5)cc4)c3c2)cnc1Cl)c1ccc(F)cc1F CHEMBL3978461 IC50 1.1 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@H](O)CC3)c2=O)cc1F CHEMBL3648966 IC50 1.1 nM
COc1ncc(-c2cc(OC3CCCC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4176338 IC50 1.1 nM
COc1ncc(-c2cc(OCC3CCCO3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4167641 IC50 1.1 nM
COc1ncc(-c2cc(OC3CCOCC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1Cl CHEMBL4160104 IC50 1.1 nM
COc1ncc(-c2cc(OC3CCOCC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(Cl)s1 CHEMBL4175228 IC50 1.1 nM
COc1ncc(-c2cc3c(C)nc(NC(C)=O)nc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4228946 IC50 1.1 nM
COc1ncc(-c2cc(OCCCN(C)c3ncc(C(=O)NO)cn3)c3ncnc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4471718 IC50 1.1 nM
COc1ncc(-c2ccc3ncn(CCCC(N)=O)c(=O)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1Cl CHEMBL4633425 IC50 1.1 nM
CNC(=O)[C@H](C)Cn1cnc2ccc(-c3cnc(OC)c(NS(=O)(=O)c4cccc(Cl)c4Cl)c3)cc2c1=O CHEMBL4640713 IC50 1.1 nM
COc1ncc(-c2ccc3nccc(/C(C)=C/C(=O)N4CCOCC4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4758904 IC50 1.1 nM
CCN(CC)C(=O)CSC(=S)N1CCN(c2nc(N3CCOCC3)nc(-n3c(C(F)F)nc4c(OC)cccc43)n2)CC1 CHEMBL5440155 IC50 1.1 nM
Cc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCOCC2)c(=O)n4C)cn1 CHEMBL3681126 Ki 1.11 nM
CNC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccc(OC)nc5)nc4c32)CC1 CHEMBL3681085 Ki 1.15 nM
COc1ncc(-c2ccc3ncc(-c4cn(CCCN5CCN(C)CC5)nn4)n3n2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL5428411 IC50 1.16 nM
Cc1nc(-c2cnc3ccc(-c4cncc(NS(=O)(=O)c5ccccc5)c4)cn23)no1 CHEMBL1765464 Kd 1.2 nM
COc1ccc(S(=O)(=O)Nc2cc(-c3ccc4nc(NC(C)=O)sc4c3)cnc2C)cc1 CHEMBL1773603 Ki 1.2 nM
CC(=O)Nc1nc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)cc2s1 CHEMBL1615189 Ki 1.2 nM
CN(C(=O)c1cc2c(s1)-c1ccc(C(N)=O)cc1OCC2)c1ccccc1Cl CHEMBL1796275 Ki 1.2 nM
COc1nc(-c2ccc(NC(=O)Nc3ccc(C(=O)N4CCN(C)CC4)cc3)cc2)nc(N2CCOCC2)n1 CHEMBL1808982 IC50 1.2 nM
CC(=O)Nc1cn2cc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)ccc2n1 CHEMBL1822057 Ki 1.2 nM
O=S(=O)(Nc1cc(-c2ccc3ncc(NCCN4CCOCC4)nc3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914736 Ki 1.2 nM
O=c1[nH]nc(-c2cc3c(s2)-c2ccccc2OCC3)n1-c1ccccc1Cl CHEMBL2322502 IC50 1.2 nM
Fc1ccc(-n2ncnc2-c2cc3c(s2)-c2ccccc2OCC3)c(F)c1 CHEMBL2322777 IC50 1.2 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1cnc(N)cc1OCC2 CHEMBL3770630 Ki(app) 1.2 nM
COc1ncc(-c2ccc3nccc(-c4ccc(CN5CCCCC5)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3914319 IC50 1.2 nM
COc1ncc(-c2ccc3nccc(-c4ccc(CN5CCN(CCO)CC5)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3951052 IC50 1.2 nM
Cc1nc(N)nc2c1cc(-c1cnc3[nH]ccc3c1)c(=O)n2[C@@H]1CC[C@H](O)C1 CHEMBL3648942 IC50 1.2 nM
Cc1nc(N)nc2c1cc(-c1cnc3[nH]ccc3c1)c(=O)n2[C@@H]1CC[C@@H](O)C1 CHEMBL3648944 IC50 1.2 nM
Cn1c(=O)n([C@H]2CC[C@H](O)CC2)c2c3nc(-c4cnc5ccccc5c4)ccc3ncc21 CHEMBL3681089 Ki 1.2 nM
Nc1ncc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)c(C(F)(F)F)n1 CHEMBL4102855 Kd 1.2 nM
COc1ncc(-c2cc(OC)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4166540 IC50 1.2 nM
COc1ncc(-c2cc(OCC3CCOC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4161649 IC50 1.2 nM
COc1ncc(-c2cc(OC3CCOCC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1 CHEMBL4167351 IC50 1.2 nM
COc1ncc(-c2ccc3ncn(CCC(N)=O)c(=O)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1Cl CHEMBL4645822 IC50 1.2 nM
COc1ncc(-c2ccc3nccc(/C(C)=C/C(=O)N4CCCC4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4787768 IC50 1.2 nM
COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCN(C(=S)SCC(=O)N3CCN(S(C)(=O)=O)CC3)CC2)n1 CHEMBL5399572 IC50 1.2 nM
COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)cc(N2CCN(C(=S)SCC(=O)N3CCOCC3)CC2)n1 CHEMBL5408043 IC50 1.2 nM
Cc1c(N2CCC2=O)nc2cc(F)cc(F)c2c1N1CC2(CCOCC2)c2ncc(N3CCOCC3)cc21 CHEMBL3701685 Ki 1.27 nM
Oc1cccc(-c2nc(N3CCOCC3)c3oc4ncccc4c3n2)c1 CHEMBL573339 Kd 1.3 nM
O=S(=O)(Nc1cc(-c2ccc3nccc(-c4ccccc4)c3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914725 Ki 1.3 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3cn(C)cn3)ccc1-2 CHEMBL2381271 IC50 1.3 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C(N)=O)ccc1-2 CHEMBL2381251 IC50 1.3 nM
COc1ncc(-c2cc3c(-c4ccncc4)ncnc3s2)cc1NS(=O)(=O)c1ccc(Cl)s1 CHEMBL3577923 IC50 1.3 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1cnc(N3CCCC3)cc1OCC2 CHEMBL3770092 Ki(app) 1.3 nM
COc1ncc(-c2ccc3nccc(-c4ccc(CN(CCO)CCO)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3924412 IC50 1.3 nM
COc1ncc(-c2ccc3nccc(-c4ccc(CN5CCN(C)CC5)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3942320 IC50 1.3 nM
COc1ncc(-c2ccc3nccc(-c4ccc(CN(C)C)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3963018 IC50 1.3 nM
Cc1nc(N)nc2c1cc(-c1cnc3[nH]ccc3c1)c(=O)n2[C@H]1CC[C@H](O)CC1 CHEMBL3648937 IC50 1.3 nM
CCn1nccc1NC(=O)c1cc2c(C)nc(N)nc2n([C@H]2CC[C@H](O)CC2)c1=O CHEMBL3652250 IC50 1.3 nM
COc1ncc(-c2nc3c(C)nc(N)nc3n(C)c2=O)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4226926 IC50 1.3 nM
COc1ncc(-c2cc3c(C)nc(N)nc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4226082 IC50 1.3 nM
COc1ncc(-c2cc(OCCCC(=O)NO)c3ncnc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4588404 IC50 1.3 nM
COc1ncc(-c2nc3c(N4CCC(OC)CC4)ncnc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4795224 IC50 1.3 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1cncc(c1)-c1ncnc3ccc-2cc13 CHEMBL4872630 IC50 1.3 nM
CCN(CC)C(=O)CSC(=S)N1CCN(c2cc(N3CCOCC3)nc(-n3c(C(F)F)nc4c(OC)cccc43)n2)CC1 CHEMBL5409119 IC50 1.3 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(N4CCCCC4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4876806 IC50 1.33 nM
COc1ncc(-c2ccc3ncc(-c4cn(CCCN5CCCCC5)nn4)n3n2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL5417402 IC50 1.33 nM
Cc1c(-c2ccccn2)nc2cc(F)ccc2c1N1CC2(CCS(=O)(=O)CC2)c2ccc(N3CCOCC3)cc21 CHEMBL3701670 Ki 1.37 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(-n4ccnc4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4871213 IC50 1.37 nM
CCOC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6ccccc6c5)nc4c32)CC1 CHEMBL3681074 Ki 1.38 nM
CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)N(C)C)cc4)cc3)nc21 CHEMBL591358 IC50 1.4 nM
CN(C)CCNC(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)c4ccn(CC(F)(F)F)c4n3)cc2)cc1 CHEMBL1092073 IC50 1.4 nM
COc1cccc(Nc2nc(-c3cccc4[nH]ncc34)nc3c2cnn3C)c1 CHEMBL1257186 IC50 1.4 nM
Cn1ncc2c(NCCCS(C)(=O)=O)nc(-c3cccc4n[nH]cc34)nc21 CHEMBL1234878 IC50 1.4 nM
Cn1ncc2c(Nc3ccc(S(C)(=O)=O)cc3)nc(-c3cccc4[nH]ncc34)nc21 CHEMBL1257534 IC50 1.4 nM
COc1ccc(S(=O)(=O)Nc2cc(-c3ccc4nc(NC(C)=O)sc4c3)cnc2C#N)cc1 CHEMBL1773602 Ki 1.4 nM
CC(=O)Nc1nc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccccc4)c3)cc2s1 CHEMBL1773605 Ki 1.4 nM
COc1nc(-c2ccc(NC(=O)Nc3ccc(C(=O)N4CCNC(C)(C)C4)cc3)cc2)nc(N2CCOCC2)n1 CHEMBL1808983 IC50 1.4 nM
O=C(Nc1ccc(C(=O)NCCN2CCCCC2)cc1)Nc1ccc(-c2nc(O[C@H]3CCOC3)nc(N3CCOCC3)n2)cc1 CHEMBL1808989 IC50 1.4 nM
O=C(Nc1ccc(C(=O)NCCN2CCCC2)cc1)Nc1ccc(-c2nc(O[C@H]3CCOC3)nc(N3CCOCC3)n2)cc1 CHEMBL1808990 IC50 1.4 nM
CC(=O)Nc1cn2nc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)ccc2n1 CHEMBL1822054 Ki 1.4 nM
CN(Cc1ccccc1)c1cnc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)cc2n1 CHEMBL1914732 Ki 1.4 nM
COC1CCN(c2cnc3ccc(-c4cnc(Cl)c(NS(=O)(=O)c5ccc(F)cc5)c4)cc3n2)CC1 CHEMBL1914741 Ki 1.4 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3ccc(N)nc3)ccc1-2 CHEMBL2381273 IC50 1.4 nM
COc1ncc(-c2ccc3nccc(N4CCOCC4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3895847 IC50 1.4 nM
COc1ncc(-c2ccc3nccc(-c4ccc(CN5CCCC5)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3933347 IC50 1.4 nM
COc1ncc(-c2cc(OCC3CC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4169963 IC50 1.4 nM
Cc1ncc(-c2cc(OC3CCOCC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4168850 IC50 1.4 nM
CNc1nc(C)c2cc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4F)c3)cc(OC3CCOCC3)c2n1 CHEMBL4166594 IC50 1.4 nM
COc1ncc(-c2cc(OC3CCOCC3)c3nc(NC(C)=O)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4159789 IC50 1.4 nM
CNc1nc(C)c2cc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4F)c3)cc(O[C@H]3CCOC3)c2n1 CHEMBL4167026 IC50 1.4 nM
COc1ncc(-c2ccc3nccc(/C(C)=C/C(=O)N4CCC(O)CC4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4750601 IC50 1.4 nM
COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCN(C(=S)SCC(=O)N3CCN(C)CC3)CC2)n1 CHEMBL5427579 IC50 1.4 nM
COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCN(C(=S)SCC(=O)NC3CC3)CC2)n1 CHEMBL5431690 IC50 1.4 nM
COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)cc(N2CCN(C(=S)SCC(=O)N3CCCC3)CC2)n1 CHEMBL5432847 IC50 1.4 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n(C3CCOCC3)c2=O)cc1F CHEMBL3649018 IC50 1.43 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@H](OCCO)CC3)c2=O)cc1F CHEMBL3652257 IC50 1.44 nM
Cc1c(N2CC(C)(C)CCC2=O)nc2cc(F)cc(F)c2c1N1CC2(CCOCC2)c2ncc(N3CCOCC3)cc21 CHEMBL3701667 Ki 1.49 nM
O=C(Nc1ccc(CCO)cc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1 CHEMBL605121 IC50 1.5 nM
CNC(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL597825 IC50 1.5 nM
COC(=O)Nc1ccc2c(c1)OCCc1cc(C(=O)N(C)c3ccccc3Cl)sc1-2 CHEMBL1796274 Ki 1.5 nM
CCc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnn2ccc(C#N)cc12 CHEMBL1928722 IC50 1.5 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CCNC3)ccc1-2 CHEMBL2381266 IC50 1.5 nM
O=S(=O)(Nc1cc(-c2ccc3nccc(-c4ccc(CN5CCOCC5)cc4)c3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL3940597 IC50 1.5 nM
Nc1cc(C(F)(F)F)c(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cn1 CHEMBL4084907 Kd 1.5 nM
CCNc1nc(C)c2cc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4F)c3)cc(OC3CCOCC3)c2n1 CHEMBL4177219 IC50 1.5 nM
COc1ncc(-c2cc3c(C)nc(N)nc3s2)cc1NS(=O)(=O)c1ccc(Cl)s1 CHEMBL4226602 IC50 1.5 nM
COc1ncc(-c2ccc3nccc(/C(C)=C/C(=O)N(C)CCO)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4741551 IC50 1.5 nM
Cc1c(CN2CCN(C(=O)c3cc4cccc(C(N)=O)c4o3)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL4865059 IC50 1.5 nM
Cc1ccc(S(C)(=O)=O)c(-c2nc3cc(F)cc(F)c3c(N3CC4(CCOCC4)c4ncc(N5CCOCC5)cc43)c2C)c1 CHEMBL3701654 Ki 1.51 nM
Cc1c(N2CCOC(C)(C)C2)nc2cc(F)cc(F)c2c1N1CC(C)(C)c2ncc(N3CCOCC3)cc21 CHEMBL3701653 Ki 1.52 nM
Cc1c(N2CCCC2=O)nc2cc(F)cc(F)c2c1N1CC(C)(C)c2ncc(N3CCOCC3)cc21 CHEMBL3701638 Ki 1.54 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(N4CCOCC4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4850400 IC50 1.55 nM
CNc1nc(C)c2cc(-c3ccc(O)c(OC)c3)c(=O)n(C3CCCC3)c2n1 CHEMBL3648910 IC50 1.57 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@@H](OCC(N)=O)CC3)c2=O)cc1F CHEMBL2375963 IC50 1.58 nM
CCNc1nc(C)c2cc(-c3cnc(OC)nc3)c(=O)n([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL3652249 IC50 1.59 nM
CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cccc(O)c4)nc(N4CCOCC4)c3s2)CC1 CHEMBL1086923 IC50 1.6 nM
COc1ccc(S(=O)(=O)Nc2cncc(-c3ccc4nc(NC(C)=O)sc4c3)c2)cc1 CHEMBL1773599 Ki 1.6 nM
CCN(Cc1ccc(-c2ccnc3ccc(-c4cnc(OC)c(NS(=O)(=O)c5ccc(F)cc5F)c4)cc23)cc1)C1CCCCC1 CHEMBL3896400 IC50 1.6 nM
COc1ncc(-c2ccc3nccc(-c4ccc(CN5CCOCC5)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1 CHEMBL3905930 IC50 1.6 nM
Cc1nc(N)nc2c1cc(-c1cnc3[nH]ccc3c1)c(=O)n2[C@H]1CC[C@@H](O)CC1 CHEMBL3648950 IC50 1.6 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@H](OC)CC3)c2=O)cc1F CHEMBL3648957 IC50 1.6 nM
CNc1nc(C)c2cc(-c3cnc4[nH]ccc4c3)c(=O)n(CC3CCOC3)c2n1 CHEMBL3648980 IC50 1.6 nM
COc1ncc(-c2cc(OC3CCC(F)(F)CC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4173411 IC50 1.6 nM
COCCOc1cc(-c2cnc(OC)c(NS(=O)(=O)c3ccc(F)cc3F)c2)cc2c(C)nc(N)nc12 CHEMBL4159325 IC50 1.6 nM
CCCC(=O)Nc1nc(C)c2cc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4F)c3)sc2n1 CHEMBL4225608 IC50 1.6 nM
CNc1nc(C)c2cc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4F)c3)sc2n1 CHEMBL4225722 IC50 1.6 nM
NC(=O)C1CCCCN1C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL5079887 IC50 1.6 nM
NC(=O)C1CCCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)nc(N5CCOCC5)n4)cc3)cc2)C1 CHEMBL5091543 IC50 1.6 nM
COc1ccc(-c2cc3c(C)nc(N)nc3n(C3CCC(OCCO)CC3)c2=O)cn1 CHEMBL5278357 Ki 1.6 nM
COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCN(C(=S)SCC(N)=O)CC2)n1 CHEMBL5400165 IC50 1.6 nM
COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCN(C(=S)SCC(=O)NC3CCC3)CC2)n1 CHEMBL5403052 IC50 1.6 nM
Cn1c(=O)n(C2CCNCC2)c2c3nc(-c4cnc(N)nc4)ccc3ncc21 CHEMBL3681153 Ki 1.61 nM
CC1CCN(c2cnnc3ccc(-c4cnc(Cl)c(NS(=O)(=O)c5ccccc5)c4)cc23)CC1 CHEMBL4878126 IC50 1.61 nM
Cc1c(N2CCCCC2=O)nc2cc(F)ccc2c1N1CC2(CCOCC2)c2ncc(N3CCOCC3)cc21 CHEMBL3701648 Ki 1.62 nM
Cc1ccc(-c2ccc3ncc4c(c3n2)n([C@H]2CC[C@H](OCCO)CC2)c(=O)n4C)cn1 CHEMBL3681094 Ki 1.68 nM
O=C(Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1)Nc1cccnc1 CHEMBL599668 IC50 1.7 nM
COc1cccc(Nc2nc(-c3cccc4onc(C)c34)nc3c2cnn3C)c1 CHEMBL1257304 IC50 1.7 nM
CN1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(O[C@H]5CCOC5)nc(N5CCOCC5)n4)cc3)cc2)CC1 CHEMBL1808991 IC50 1.7 nM
CN(C)c1cnc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)cc2n1 CHEMBL1914737 Ki 1.7 nM
Cc1c(CN2CCN(C(=O)C(C)(C)O)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1922095 IC50 1.7 nM
N#Cc1c(N2CCOCC2)sc(-c2nc[nH]n2)c1-c1ccc(Cl)cc1 CHEMBL2017648 Ki 1.7 nM
Cc1ncc(-c2cc3c(-c4ccncc4)ncnc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3577924 IC50 1.7 nM
COc1ncc(-c2ccc3nccc(-c4ccc(CN5CCN(C(C)C)CC5)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3923330 IC50 1.7 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n(C3CCCC3)c2=O)cc1F CHEMBL3649010 IC50 1.7 nM
Cc1nc(N)nc2c(OC3CCOCC3)cc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)cc12 CHEMBL4176704 IC50 1.7 nM
COc1ncc(-c2ccc3ncn(C[C@@H](C)C(=O)NCCO)c(=O)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1Cl CHEMBL4644445 IC50 1.7 nM
COc1ncc(-c2nc3c(N4CCOCC4)ncnc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4798343 IC50 1.7 nM
CS(=O)(=O)N1CCN(Cc2cn3c(Cl)c(-c4cnc(N)nc4)nc(N4CCOCC4)c3n2)CC1 CHEMBL2087493 Ki(app) 1.73 nM
CS(=O)(=O)N1CCN(Cc2cn3cc(-c4cnc(N)nc4)nc(N4CCOCC4)c3n2)CC1 CHEMBL2087474 Ki(app) 1.77 nM
CCNc1nc(C)c2cc(-c3cnc4[nH]ccc4c3)c(=O)n(C3CCCC3)c2n1 CHEMBL3648922 IC50 1.77 nM
Cc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(CCO)CC2)c(=O)n4C)cn1 CHEMBL3681102 Ki 1.77 nM
CCOc1cnnc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccccc4)c3)cc12 CHEMBL4860613 IC50 1.78 nM
CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cccc(CO)c4)nc(N4CCOCC4)c3s2)CC1 CHEMBL1085160 IC50 1.8 nM
CCn1ccc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)NCCN(C)C)cc4)cc3)nc21 CHEMBL1092402 IC50 1.8 nM
CC(C)N1CCN(c2ccnc3ccc(-c4cnc(Cl)c(NS(=O)(=O)c5ccc(F)cc5)c4)cc23)CC1 CHEMBL1914722 Ki 1.8 nM
CC(C)c1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnn2ccc(C#N)cc12 CHEMBL1928723 IC50 1.8 nM
N#Cc1c(N2CCOCC2)sc(-c2cc[nH]n2)c1-c1ccc(Cl)cc1 CHEMBL2017649 Ki 1.8 nM
CNc1nc(C)c2cc(-c3ccc(OC)nc3)c(=O)n([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL3652247 IC50 1.8 nM
COc1ccc(CN2CCC(c3ccc4nc(C(=O)N5CCN(Cc6ccc(C(F)(F)F)cc6)CC5)cn4c3)CC2)cn1 CHEMBL3904401 IC50 1.8 nM
CNc1nc(C)c2cc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4F)c3)cc(OC3CCOC(C)(C)C3)c2n1 CHEMBL4163575 IC50 1.8 nM
CNc1nc(C)c2cc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4F)c3)cc(OCC3CCOCC3)c2n1 CHEMBL4164634 IC50 1.8 nM
COc1ncc(-c2cc(OCCN(C)c3ncc(C(=O)NO)cn3)c3ncnc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4444204 IC50 1.8 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCCN(C(=O)c5coc([N+](=O)[O-])c5)C4)c3c2)cc1C#N CHEMBL4457318 IC50 1.8 nM
CNC(=O)[C@H](C)Cn1cnc2ccc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4Cl)c3)cc2c1=O CHEMBL4632970 IC50 1.8 nM
C[C@@H]1COCCN1c1nc(-c2ccc(NC(=O)Nc3ccc(C(=O)N4CCC[C@H]4C(N)=O)cc3)cc2)nc(N2CCOCC2)n1 CHEMBL5080996 IC50 1.8 nM
COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)cc(N2CCN(C(=S)SCC(=O)N(C)C)CC2)n1 CHEMBL5436787 IC50 1.8 nM
COc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)[C@H](C)O)CC2)c(=O)n4C)cc1 CHEMBL3681187 Ki 1.84 nM
COc1ccc(-c2ccc3ncc4[nH]c(=O)n(-c5ccc(C(C)(C)C#N)cc5)c4c3n2)cn1 CHEMBL3681054 Ki 1.86 nM
O=S(=O)(Nc1cc(-c2ccc3nccc(N4CCCCC4)c3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914720 Ki 1.9 nM
Cc1nc(N)nc(-c2cc(CN3CCOCC3)cnc2Nc2cnc(Cl)c(NS(=O)(=O)N(C)C)c2)n1 CHEMBL2206909 Ki 1.9 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CN(CCO)C3)ccc1-2 CHEMBL2381274 Ki(app) 1.9 nM
C[C@H]1COCCN1c1nc(-c2cnc(N)nc2C(F)F)nc(N2CCOCC2)n1 CHEMBL4445573 Ki 1.9 nM
COc1ncc(-c2nc3c(N4CCOC[C@H]4C)ncnc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4788408 IC50 1.9 nM
NC(=O)[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL5083002 IC50 1.9 nM
CNC(=O)Nc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)[C@H](C)O)CC2)c(=O)n4C)cc1 CHEMBL3681166 Ki 1.94 nM
COc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)CO)CC2)c(=O)n4C)cc1 CHEMBL3681188 Ki 1.94 nM
Cc1ccnc(-c2nc3cc(F)ccc3c(N3CCS(=O)(=O)c4ncc(N5CCOCC5)cc43)c2C)c1 CHEMBL3701656 Ki 1.96 nM
CNC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6ccccc6c5)nc4c32)CC1 CHEMBL3681070 Ki 1.96 nM
CC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccc(C)nc5)nc4c32)CC1 CHEMBL2331662 Ki 1.97 nM
Oc1cccc(-c2nc(N3CCOCC3)c3sccc3n2)c1 CHEMBL541643 IC50 2.0 nM
O=C(Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1)Nc1cccs1 CHEMBL599667 IC50 2.0 nM
CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cnc(N)nc4)nc(N4CCOCC4)c3s2)CC1 CHEMBL1083192 IC50 2.0 nM
Cc1c(-c2cccc(C(=O)N3CCN(C)CC3)c2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1093267 IC50 2.0 nM
O=CCn1ccc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)nc21 CHEMBL1091130 IC50 2.0 nM
COc1ccc2[nH]c(-c3ccccc3)c(/C=C3\Oc4cc(O)cc(O)c4C3=O)c2c1 CHEMBL1090115 IC50 2.0 nM
CC(=O)c1cnc2ccc(-c3cncc(NS(=O)(=O)c4ccccc4)c3)cn12 CHEMBL1765461 IC50 2.0 nM
Cc1nc(-c2cnc3ccc(-c4cncc(NS(=O)(=O)c5ccc(F)cc5F)c4)cn23)no1 CHEMBL1765626 IC50 2.0 nM
COc1nc(-c2ccc(NC(=O)Nc3ccc(C(=O)NCCN4CCCCC4)cc3)cc2)nc(N2CCOCC2)n1 CHEMBL1808978 IC50 2.0 nM
CNC(=O)c1ccc2c(c1)OCCc1cc(C(=O)N(C)c3ccc(C(=O)N(C)C)cc3Cl)sc1-2 CHEMBL1796761 IC50 2.0 nM
Nc1ncc(-c2nc(N3CCOCC3)c3cc(CC4CCN(CC(F)(F)F)CC4)sc3n2)cn1 CHEMBL1949914 Ki(app) 2.0 nM
CN(Cc1cc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc2s1)S(C)(=O)=O CHEMBL1949917 Ki(app) 2.0 nM
CN(C)C(=O)N1CCN(Cc2cc3c(N4CCOCC4)nc(-c4cnc(N)nc4)nc3s2)CC1 CHEMBL1949918 Ki(app) 2.0 nM
Cc1ncnc(-n2c(Nc3cccc(O)c3)nc3ccccc32)n1 CHEMBL2165051 Ki 2.0 nM
Cc1nc(N)nc(-c2cc(C3CCOCC3)cnc2Nc2cnc(Cl)c(NS(C)(=O)=O)c2)n1 CHEMBL2206907 Ki 2.0 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3ncc[nH]3)ccc1-2 CHEMBL2381270 IC50 2.0 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CCNCC3)ccc1-2 CHEMBL2381268 IC50 2.0 nM
CC(C)(O)c1nc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc2n1CCO CHEMBL2418352 Ki 2.0 nM
CC(=O)Nc1cn2nc(-c3cnc(N)c(C(F)(F)F)c3)ccc2n1 CHEMBL2418953 IC50 2.0 nM
Oc1cccc(-c2nc(N3CCOCC3)c3sccc3n2)c1 CHEMBL510164 IC50 2.0 nM
CC(=O)Nc1cn2cc(-c3cnc(N)c(OC(C)C)n3)ccc2n1 CHEMBL3753366 IC50 2.0 nM
COc1ncc(-c2ccc3nccc(C#CCN4CCN(S(C)(=O)=O)CC4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3763244 IC50 2.0 nM
CC1(C)OCCn2c1nc1c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL3813842 Ki(app) 2.0 nM
Cc1nc(N)ncc1-c1nc(N2CCOCC2)c2nc3n(c2n1)CCOC3(C)C CHEMBL3814414 Ki(app) 2.0 nM
COC1(c2sc3c(N4CCOCC4)nc(-c4cnc(N)nc4)nc3c2C)COC1 CHEMBL2178608 Ki(app) 2.0 nM
CCc1nc(N)nc(N2CCC(OC)CC2)c1C#Cc1cnc(C)c(NS(C)(=O)=O)c1 CHEMBL3655888 IC50 2.0 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)C(C)C CHEMBL3655892 IC50 2.0 nM
CCc1ncnc(N2CCCCC2)c1C#Cc1cnc(C)c(NS(C)(=O)=O)c1 CHEMBL3655898 IC50 2.0 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1ccco1 CHEMBL3655903 IC50 2.0 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)c1c(C)noc1C CHEMBL3660098 IC50 2.0 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCN(C)C(=O)C2)cc1NS(=O)(=O)c1ccccc1 CHEMBL3660104 IC50 2.0 nM
CC(=O)N1CCN(c2ncnc(C)c2C#Cc2cnc(C)c(NS(=O)(=O)c3ccccc3)c2)CC1 CHEMBL3660105 IC50 2.0 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)N1CCCC1 CHEMBL3660108 IC50 2.0 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOC[C@H]2C)cc1NS(=O)(=O)c1ccccc1 CHEMBL3660113 IC50 2.0 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCCOCC2)cc1NS(=O)(=O)c1ccccc1 CHEMBL3660116 IC50 2.0 nM
COC1CCN(c2ncnc(C)c2C#Cc2cnc(C)c(NS(=O)(=O)c3ccccc3)c2)CC1 CHEMBL3660117 IC50 2.0 nM
CCc1ncnc(N2CCOCC2)c1C#Cc1cnc(OC)c(NS(=O)(=O)CC)c1 CHEMBL3660119 IC50 2.0 nM
CCc1ncnc(N2CCOCC2)c1C#Cc1cnc(OC)c(NS(=O)(=O)CCOC)c1 CHEMBL3660121 IC50 2.0 nM
Cc1nc(N)nc2c1cc(-c1cnc3[nH]ccc3c1)c(=O)n2C1CCC1 CHEMBL3648974 IC50 2.0 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n(C3CCCC3)c2=O)cn1 CHEMBL3649011 IC50 2.0 nM
O=S(=O)(Nc1cc(-c2cnc3ccc(-c4ccncc4)cn23)cnc1Cl)c1ccc(F)cc1 CHEMBL3649427 Ki 2.0 nM
COc1ccc(Nc2ncc(Cc3ccc(S(C)(=O)=O)cc3)cc2-c2nc(C)nc3[nH]cnc23)cn1 CHEMBL3646449 Ki 2.0 nM
COc1ccc(Nc2ncc(Cc3ccc(S(C)(=O)=O)cc3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165007 Ki 2.0 nM
COc1ncc(Nc2ncc(Cc3ccc(S(C)(=O)=O)cc3)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL3646480 Ki 2.0 nM
COc1ncc(Nc2ncc(C(C)N3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL3646481 Ki 2.0 nM
Cc1nc(N)nc(-c2cccnc2Nc2ccc(NC(=O)Nc3ccccc3)nc2)n1 CHEMBL3646517 Ki 2.0 nM
COc1ncc(Nc2ncc(CN3CCN(S(C)(=O)=O)C[C@@H]3C)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL2170083 Ki 2.0 nM
COc1ncc(Nc2ncc(C(C)(C)N3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL2170090 Ki 2.0 nM
COc1ncc(Nc2ncc([C@@H](C)N3CCN(S(C)(=O)=O)CC3)cc2-c2cc(N)nc(C)n2)cc1F CHEMBL3646595 Ki 2.0 nM
COc1ncc(Nc2ncc(C(C)CO)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL3646601 Ki 2.0 nM
COc1ncc(Nc2ncc(CN3CCN(S(C)(=O)=O)C[C@H]3C)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL2170082 Ki 2.0 nM
COc1ncc(Nc2ncc([C@@H](C)N3CCN(S(C)(=O)=O)C[C@@H]3C)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL3646632 Ki 2.0 nM
Cc1nc(N)nc(-c2cc(Cl)cnc2Nc2cnc(Cl)c(NS(=O)(=O)N(C)C)c2)n1 CHEMBL2206921 Ki 2.0 nM
CNc1nc(C)c2cc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4F)c3)cc(OCC3CCOC3)c2n1 CHEMBL4171472 IC50 2.0 nM
COc1ncc(-c2cnc3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3112718 IC50 2.0 nM
C[C@H]1COCCN1c1cc(-c2cnc(N)nc2C(F)F)nc(N2CCOCC2)n1 CHEMBL4515766 Ki 2.0 nM
COc1ncc(-c2ccc3ncn(C[C@@H](C)C(N)=O)c(=O)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1Cl CHEMBL4633266 IC50 2.0 nM
COc1ncc(-c2nc3c(N4CCOC[C@@H]4C)ncnc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4759861 IC50 2.0 nM
Cc1c(CN2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL4858564 IC50 2.0 nM
COc1ncc2cc1NS(=O)(=O)c1cc(c(F)cc1F)C(=O)NCc1cccc(c1)-c1ccnc3ccc-2cc13 CHEMBL4872284 IC50 2.0 nM
O=C(NOCCOCCOCCOCCC(=O)N1CCN(c2cnc3ccc(-c4cnc(Cl)c(NS(=O)(=O)c5ccc(F)cc5)c4)cc3n2)CC1)c1ccc(F)c(F)c1Nc1ccc(I)cc1F CHEMBL5219124 IC50 2.0 nM
COc1cccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)[C@H](C)O)CC2)c(=O)n4C)c1 CHEMBL3681190 Ki 2.01 nM
COc1ncc(-c2cc3c(-c4ccncc4)ncnc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3577921 IC50 2.07 nM
COc1ncc(-c2cc(OC3CCOCC3)c3ncnc(C)c3c2)cc1N(Cc1cc2ccc(O)cc2oc1=O)S(=O)(=O)c1ccc(F)cc1F CHEMBL5426265 IC50 2.07 nM
COc1ncc(-c2ccc3ncc4c(c3n2)n([C@H]2CC[C@H](OCCO)CC2)c(=O)n4C)cn1 CHEMBL3681091 Ki 2.09 nM
O=S(=O)(Nc1cc(-c2ccc3ncccc3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914710 Ki 2.1 nM
Cc1c(CN2CCN(C(=O)[C@H](C)N)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1922091 IC50 2.1 nM
COc1ncc(-c2ccc3nccc(C#CCN4CCOCC4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3764625 IC50 2.1 nM
COc1ncc(-c2ccc3nccc(-c4ccc(CN(C)C)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1 CHEMBL3925191 IC50 2.1 nM
CN(C)CC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccc(N(C)C)nc5)nc4c32)CC1 CHEMBL3681087 Ki 2.1 nM
CC(=O)Nc1nc(C)c(-c2cnc(Cl)c(NS(=O)(=O)c3ccccc3)c2)s1 CHEMBL4174132 IC50 2.1 nM
COc1ncc(-c2ccc3ncnc(NC4CCN(C(=O)C5CCOCC5)CC4)c3c2)cc1NS(C)(=O)=O CHEMBL4552869 IC50 2.1 nM
COc1ncc(-c2ccc3ncn(C[C@@H](C)C(=O)NC4COC4)c(=O)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1Cl CHEMBL4642802 IC50 2.1 nM
CNC(=O)[C@H](C)Cn1cnc2ccc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(Cl)cc4Cl)c3)cc2c1=O CHEMBL4632604 IC50 2.1 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCCn1cc(cn1)-c1cnc3ccc-2nn13 CHEMBL4873529 IC50 2.1 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3C[C@H](OCC(N)=O)C3)c2=O)cc1F CHEMBL3652273 IC50 2.14 nM
CNC(=O)Nc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)CO)CC2)c(=O)n4C)cc1 CHEMBL3681167 Ki 2.19 nM
CN(C)c1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnn2ccc(C#N)cc12 CHEMBL1928727 IC50 2.2 nM
Nc1ncc(-c2cc(Nc3cnc4ccccc4c3)nc(N3CCOCC3)n2)c(C(F)(F)F)n1 CHEMBL2017970 IC50 2.2 nM
O=C1NC(=S)S/C1=C\c1ccc2ncsc2c1 CHEMBL3775393 IC50 2.2 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n(C(C)C)c2=O)cn1 CHEMBL3649019 IC50 2.2 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@H](OCCO)CC3)c2=O)cn1 CHEMBL3652256 IC50 2.2 nM
COc1ncc(-c2cc3c(C)nc(N)nc3s2)cc1NS(=O)(=O)c1ccc(F)cc1 CHEMBL4225799 IC50 2.2 nM
Cc1nc(N)nc2sc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)cc12 CHEMBL4227319 IC50 2.2 nM
CCC(=O)Nc1nc(C)c2cc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4F)c3)sc2n1 CHEMBL4227858 IC50 2.2 nM
Nc1ncc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)c(C(F)F)n1 CHEMBL4744705 Ki 2.2 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1cncc(c1)-c1ccnc3ccc-2cc13 CHEMBL4850101 IC50 2.2 nM
N[C@H]1CC[C@H](n2c(=O)[nH]c3cnc4ccc(-c5cnc6ccccc6c5)nc4c32)CC1 CHEMBL3681120 Ki 2.21 nM
Cc1c(-c2ccccn2)nc2cc(F)ccc2c1N1CCS(=O)(=O)c2ncc(N3CCOCC3)cc21 CHEMBL3701655 Ki 2.22 nM
COc1cccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)CO)CC2)c(=O)n4C)c1 CHEMBL3639800 Ki 2.22 nM
COc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)CN(C)C)CC2)c(=O)n4C)cn1 CHEMBL3681081 Ki 2.23 nM
Cc1c(-c2cncc(F)c2)nc2ncccc2c1N1CC(C)(C)c2ncc(N3CCOCC3)cc21 CHEMBL3701687 Ki 2.24 nM
COc1ncc(-c2ccc3nccc(Cl)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3904794 IC50 2.3 nM
Cc1nc(N)nc2c1cc(-c1cnc3[nH]ccc3c1)c(=O)n2C(C)C CHEMBL3648975 IC50 2.3 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@H](O)CC3)c2=O)cn1 CHEMBL3652246 IC50 2.3 nM
Cc1c(-c2cccc(F)c2)nc2ncccc2c1N1CC(C)(C)c2ncc(N3CCOCC3)cc21 CHEMBL3701672 Ki 2.3 nM
Cc1c(N2CC(C)(C)CC2=O)nc2cc(F)cc(F)c2c1N1CC2(CCOCC2)c2ncc(N3CCOCC3)cc21 CHEMBL3701686 Ki 2.3 nM
Cc1nc(NC(=O)CN)sc1-c1cnc(Cl)c(NS(=O)(=O)c2ccccc2)c1 CHEMBL4170707 IC50 2.3 nM
CCC(=O)Nc1nc(C)c(-c2cnc(Cl)c(NS(=O)(=O)c3ccccc3)c2)s1 CHEMBL4166220 IC50 2.3 nM
COc1ncc(-c2cc3c(C)nc(NC(=O)C4CC4)nc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4226543 IC50 2.3 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCN(C(=O)C5CCCC5)C4)c3c2)cc1NS(C)(=O)=O CHEMBL4436369 IC50 2.3 nM
COc1ncc(-c2cc(OCCCCCCC(=O)NO)c3ncnc(C)c3c2)cc1NS(C)(=O)=O CHEMBL4456391 IC50 2.3 nM
CNC(=O)[C@@H](C)Cn1cnc2ccc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4Cl)c3)cc2c1=O CHEMBL4635942 IC50 2.3 nM
Cc1c(CN2CCN(C(=O)c3cc4cccc(C(N)=O)c4o3)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)cc3C(F)(F)F)nc12 CHEMBL4861171 IC50 2.3 nM
COc1cccc(Cc2nc3cc(F)cc(F)c3c(N3CC(C)(C)c4ncc(N5CCOCC5)cc43)c2C)c1 CHEMBL3698366 Ki 2.34 nM
COc1ncc(-c2ccc3ncc4c(c3n2)n(-c2ccc(C(C)(C)C#N)cc2)c(=O)n4C)cc1F CHEMBL3681059 Ki 2.35 nM
Cc1c(N2CCCC2=O)nc2cc(F)cc(F)c2c1N1CC2(CCOCC2)c2ncc(N3CCOCC3)cc21 CHEMBL3701647 Ki 2.36 nM
Cc1ccnc(-c2nc3ncccc3c(N3CC(C)(C)c4ncc(N5CCOCC5)cc43)c2C)c1 CHEMBL3701664 Ki 2.36 nM
COc1ccc(-c2ccc3ncc4[nH]c(=O)n(Cc5ccccc5)c4c3n2)cn1 CHEMBL3681077 Ki 2.39 nM
CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(N)=O)cc4)cc3)nc21 CHEMBL591759 IC50 2.4 nM
CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)NCCCN(C)C)cc4)cc3)nc21 CHEMBL590594 IC50 2.4 nM
CN1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)c5ccn(CC(F)(F)F)c5n4)cc3)cc2)CC1 CHEMBL1092074 IC50 2.4 nM
C#Cc1ccn2ncc(/C=N/N(C)S(=O)(=O)c3cc([N+](=O)[O-])ccc3C)c2c1 CHEMBL1928536 IC50 2.4 nM
Cc1ccc(C#N)cc1S(=O)(=O)N(C)/N=C/c1cnn2ccc(C#N)cc12 CHEMBL1928571 IC50 2.4 nM
Nc1cc(Cl)c(-c2cc(Nc3cnc4ccccc4c3)nc(N3CCOCC3)n2)cn1 CHEMBL2017965 IC50 2.4 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@@H](O)CC3)c2=O)cc1F CHEMBL3648955 IC50 2.4 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n(C)c2=O)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4225819 IC50 2.4 nM
COc1ncc(-c2cc3c(C)nc(N)cc3n([C@H]3CC[C@H](OCCO)CC3)c2=O)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3112730 IC50 2.42 nM
O=c1[nH]c2cnc3ccc(-c4cnc5ccccc5c4)nc3c2n1C1CCNCC1 CHEMBL3681066 Ki 2.43 nM
Cc1c(-c2ccccc2S(C)(=O)=O)nc2cc(F)ccc2c1N1CC(C)(C)c2ncc(-c3ccnc(N)n3)cc21 CHEMBL3698300 Ki 2.437 nM
Cc1nc(N)cc2c1cc(-c1cnc3[nH]ccc3c1)c(=O)n2C1CCCC1 CHEMBL3112725 IC50 2.45 nM
CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4cccs4)cc3)nc21 CHEMBL590084 IC50 2.5 nM
CNC(=O)c1ccc(N(C)C(=O)c2cc3c(s2)-c2ccc(C(=O)NC)cc2OCC3)c(Cl)c1 CHEMBL1796760 Ki 2.5 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(CO)ccc1-2 CHEMBL2381261 IC50 2.5 nM
CNCCN(C)Cc1ccc(-c2ccnc3ccc(-c4cnc(OC)c(NS(=O)(=O)c5ccc(F)cc5F)c4)cc23)cc1 CHEMBL3905333 IC50 2.5 nM
COc1ccc(CN2CCC(c3ccc4nc(C(=O)N5CCN(Cc6ccc(C(F)(F)F)cc6)CC5)n(C)c4c3)CC2)cn1 CHEMBL3955631 IC50 2.5 nM
COc1ncc(-c2cc(OC3CCOCC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)C1CC1 CHEMBL4160524 IC50 2.5 nM
COc1ncc(-c2ccc3ncn(C[C@@H](C)C(=O)NCCF)c(=O)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1Cl CHEMBL4646316 IC50 2.5 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1cccc(c1)-c1ncnc3ccc-2cc13 CHEMBL4854600 IC50 2.5 nM
COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCN(C(=S)SCC(=O)N3CCN(C4CCCC4)CC3)CC2)n1 CHEMBL5417620 IC50 2.5 nM
COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)cc(N2CCN(C(=S)SCC(N)=O)CC2)n1 CHEMBL5429468 IC50 2.5 nM
NC(=O)[C@@H]1CCCN1c1ccc2c(c1)OCCn1cc(N3CCOCC3=O)nc1-2 CHEMBL5192556 Ki 2.52 nM
CN(C)CC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6ccccc6c5)nc4c32)CC1 CHEMBL3681073 Ki 2.55 nM
COc1ncc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)[C@H](C)O)CC2)c(=O)n4C)cn1 CHEMBL3681095 Ki 2.59 nM
O=S(=O)(Nc1cc(-c2ccc3ncncc3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914716 Ki 2.6 nM
Nc1ncc(-c2cc(Nc3cnc4ccccc4c3)nc(N3CCOCC3)n2)c(N)n1 CHEMBL2017968 IC50 2.6 nM
O=C1NC(=S)S/C1=C\c1ccc2ncccc2c1 CHEMBL3774448 IC50 2.6 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@@H](OCCO)CC3)c2=O)cc1F CHEMBL3652263 IC50 2.6 nM
COc1ncc(-c2cc(OC3CCOCC3)c3nc(N)nc(C)c3c2)cc1NS(C)(=O)=O CHEMBL4171779 IC50 2.6 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCN(C(=O)C(C)(C)C)C4)c3c2)cc1NS(C)(=O)=O CHEMBL4513335 IC50 2.6 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(N4CCCC4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4845684 IC50 2.64 nM
Cc1c(Cc2cccc(C#N)c2)nc2cc(F)cc(F)c2c1N1CC(C)(C)c2ncc(N3CCOCC3)cc21 CHEMBL3698357 Ki 2.676 nM
Cc1nc2c(Cl)cccc2c(N2CC3(CCOCC3)c3ncc(N4CCOCC4)cc32)c1C CHEMBL3701646 Ki 2.68 nM
COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C(C3=O)[C@@H]2CC[C@H](O)[C@@]2(C)C[C@H]1OC(C)=O CHEMBL273832 IC50 2.7 nM
CCn1ccc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)N5CCN(C)CC5)cc4)cc3)nc21 CHEMBL1092403 IC50 2.7 nM
COCCNC(=O)c1cn2cc(-c3cnc(N)nc3)nc(N3CCOCC3)c2n1 CHEMBL2058166 IC50 2.7 nM
CCOc1ccc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@H](O)CC3)c2=O)cn1 CHEMBL3648964 IC50 2.7 nM
Cc1c(N2CCN(C(=O)OC(C)(C)C)CC2)nc2cc(F)cc(F)c2c1N1CC2(CCOCC2)c2ncc(N3CCOCC3)cc21 CHEMBL3701668 Ki 2.7 nM
COc1ncc(-c2ccc3ncn(CC(F)(F)C(N)=O)c(=O)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1Cl CHEMBL4640571 IC50 2.7 nM
COc1ncc(-c2ccc3ncn(C[C@@H](C)C(=O)NC4CC4)c(=O)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1Cl CHEMBL4634579 IC50 2.7 nM
C[C@@H]1COCCN1c1nc(-c2cnc(N)nc2C(F)F)nc(N2CCOCC2)n1 CHEMBL4758284 Ki 2.7 nM
COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)cc(N2CCN(C(=S)SCC(=O)NC3CC3)CC2)n1 CHEMBL5419087 IC50 2.7 nM
Cc1c(-c2cccc3[nH]ccc23)nc2cc(F)cc(F)c2c1N1CC(C)(C)c2ncc(N3CCOCC3)cc21 CHEMBL3698354 Ki 2.766 nM
Nc1cn2cc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)ccc2n1 CHEMBL1822058 Ki 2.8 nM
Cc1c(CN2CCN(C(=O)CO)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1922093 Ki(app) 2.8 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(CCO)c4)cc2OCC3)n(C)n1 CHEMBL2387085 Ki 2.8 nM
COc1ccc(-c2cc3c(C)nc(N)nc3n(C3CCCC3)c2=O)cn1 CHEMBL2057725 IC50 2.8 nM
Cc1nc(N)nc2c1cc(-c1cnc3[nH]ccc3c1)c(=O)n2CC1CCOC1 CHEMBL3648984 IC50 2.8 nM
COc1ccc(CN2CCC(c3ccn4nc(C(=O)N5CCN(Cc6ccc(C(F)(F)F)cc6)CC5)cc4c3)CC2)cn1 CHEMBL3978948 IC50 2.8 nM
COc1ncc(-c2cc3c(C)nc(N)nc3s2)cc1NS(C)(=O)=O CHEMBL4225944 IC50 2.8 nM
COc1ncc(-c2ccc3ncnc(NC4CCN(C(=O)C5CCCC5)CC4)c3c2)cc1NS(C)(=O)=O CHEMBL4463308 IC50 2.8 nM
COc1c(OCCCCCC(=O)NO)ccc2c1N=C(NC(=O)c1ccccc1)N1CCN=C21 CHEMBL5170300 IC50 2.8 nM
COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCN(C(=S)SCC(=O)NC3CCCC3)CC2)n1 CHEMBL5417605 IC50 2.8 nM
COc1ncc(-c2cnc3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(C#N)cc1 CHEMBL3327006 IC50 2.82 nM
Cc1c(Cc2cccc(F)c2)nc2cc(F)cc(F)c2c1N1CC(C)(C)c2ncc(N3CCOCC3)cc21 CHEMBL3698355 Ki 2.874 nM
CC(C)OC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6ccccc6c5)nc4c32)CC1 CHEMBL3681075 Ki 2.89 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnn2ccc(Cl)cc12 CHEMBL1928533 IC50 2.9 nM
OCCn1cc(-c2ccc3c(c2)OCCn2cc(-c4ncnn4CC(F)(F)F)nc2-3)cn1 CHEMBL2387087 IC50 2.9 nM
Cc1nc(N)cc2c1cc(-c1cnc3[nH]cnc3c1)c(=O)n2C1CCCC1 CHEMBL3112727 IC50 2.9 nM
Cc1nc(N)nc2c1cc(C(=O)Nc1ccn[nH]1)c(=O)n2C(C)C CHEMBL3652251 IC50 2.9 nM
C=C(c1ccccc1)c1nc2cc(F)cc(F)c2c(N2CC(C)(C)c3ncc(N4CCOCC4)cc32)c1C CHEMBL3698351 Ki 2.9 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCC1CCN(CC1)c1ccnc3ccc-2cc13 CHEMBL4866790 IC50 2.9 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1cccc(c1)-c1ncnc3sc-2cc13 CHEMBL4875080 IC50 2.9 nM
C=CC(=O)N1CCC(C(=O)NCC(=O)N2CCN(c3nc(-c4cnc(N)nc4C(F)F)nc(N4CCOCC4)n3)CC2)CC1 CHEMBL5273641 IC50 2.9 nM
Cc1nc(NC(=O)N2C[C@H](NS(=O)(=O)Cc3ccc(C(=O)NO)cc3)C[C@H]2C(N)=O)sc1-c1ccnc(C(C)(C)C(F)(F)F)c1 CHEMBL5439214 IC50 2.9 nM
Cn1c(=O)n(C2CCC(C(=O)OCc3ccccc3)CC2)c2c3nc(-c4cnc5ccccc5c4)ccc3ncc21 CHEMBL3681065 Ki 2.91 nM
NC(=O)[C@@H]1COCCN1c1ccc2c(c1)OCCn1cc(N3C(=O)OC[C@H]3C(F)(F)F)nc1-2 CHEMBL5206005 Ki 2.97 nM
O=C(CCCCCOc1ccc2c(c1)N=C(NC(=O)c1ccccc1)N1CCN=C21)NO CHEMBL5218611 IC50 2.98 nM
CN(C)Cc1cc2nc(-c3cccc(O)c3)nc(N3CCOCC3)c2s1 CHEMBL493289 IC50 3.0 nM
O=C(Nc1ccccc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1 CHEMBL604908 IC50 3.0 nM
O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1 CHEMBL596597 IC50 3.0 nM
O=C(Nc1ccc(-c2nc(N3CCOCC3)c3nnn(C4CC4)c3n2)cc1)Nc1cccs1 CHEMBL601073 IC50 3.0 nM
CCNC(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)c4nnn(CC)c4n3)cc2)cc1 CHEMBL591357 IC50 3.0 nM
CC(=O)N(C)Cc1sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc2c1C CHEMBL1091979 IC50 3.0 nM
COc1ccc2[nH]c(C)c(/C=C3\Oc4cc(O)cc(O)c4C3=O)c2c1 CHEMBL1088835 IC50 3.0 nM
Cn1ncc2c(Oc3ccc(S(C)(=O)=O)cc3)nc(-c3cccc4[nH]ncc34)nc21 CHEMBL1257535 IC50 3.0 nM
COc1ccc(-c2c[nH]c3ncc(-c4cnc(N)c(NS(=O)(=O)c5ccc(F)cc5F)c4)cc23)cc1OC CHEMBL1289351 IC50 3.0 nM
CC(C)Oc1nc(-c2ccc(NC(=O)Nc3ccc(C(=O)N4CCN(C)CC4)cc3)cc2)nc(N2CCOCC2)n1 CHEMBL1808985 IC50 3.0 nM
CC(C)Oc1nc(-c2ccc(NC(=O)Nc3ccc(C(=O)NCCN(C)C)cc3)cc2)nc(N2CCOCC2)n1 CHEMBL1808987 IC50 3.0 nM
FC(F)Oc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL1911002 IC50 3.0 nM
CC(C)(O)c1cc2nc(-c3cnc(N)nc3)nc(N3CCOCC3)c2s1 CHEMBL1084926 IC50 3.0 nM
CS(=O)(=O)N1CCN(Cc2cc3c(N4CCOCC4)nc(-c4cccc5[nH]ncc45)nc3s2)CC1 CHEMBL1949908 IC50 3.0 nM
CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3o2)CC1 CHEMBL1949909 IC50 3.0 nM
CNC(=O)c1ccc2c(c1)OCCc1cc(C(=O)N(C)c3cc(C(=O)N(C)C)ccc3Cl)sc1-2 CHEMBL1796763 IC50 3.0 nM
CN(C(=O)c1cc2c(s1)-c1ccc(-c3ccn[nH]3)cc1OCC2)c1ccccc1Cl CHEMBL1949920 Ki(app) 3.0 nM
CN(C(=O)c1cc2c(s1)-c1cc(C#N)ccc1OCC2)c1ccccc1Cl CHEMBL1950036 Ki(app) 3.0 nM
N#Cc1c(N2CCOCC2)sc(-c2cn[nH]n2)c1-c1ccc(Cl)cc1 CHEMBL2017650 Ki 3.0 nM
CC(=O)Nc1cn2cc(-c3cnc(N)c(OC(C)C(F)(F)F)n3)ccc2n1 CHEMBL3753450 IC50 3.0 nM
CC(=O)Nc1cn2cc(-c3cnc(N)c(OCC(F)(F)F)n3)ccc2n1 CHEMBL3752019 IC50 3.0 nM
CCOc1nc(-c2ccc3nc(NC(C)=O)cn3c2)cnc1N CHEMBL3752653 IC50 3.0 nM
COc1nc(-c2ccc3nc(NC(C)=O)cn3c2)cnc1N CHEMBL3752503 IC50 3.0 nM
Cn1c(C2(O)COC2)nc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc21 CHEMBL3814925 Ki(app) 3.0 nM
Cn1c(C2CCC2)nc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc21 CHEMBL3814544 Ki(app) 3.0 nM
Cc1nc(N)ncc1-c1nc(N2CCOCC2)c2nc(C(C)(C)O)n(CCO)c2n1 CHEMBL3813906 Ki(app) 3.0 nM
CCc1nc(N)nc(N2CCC(C)(O)CC2)c1C#Cc1cnc(C)c(NS(C)(=O)=O)c1 CHEMBL3655897 IC50 3.0 nM
CC(=O)N1CCCN(c2ncnc(C)c2C#Cc2cnc(C)c(NS(=O)(=O)c3ccccc3)c2)CC1 CHEMBL3660106 IC50 3.0 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCCCC2)cc1NS(=O)(=O)c1ccccc1 CHEMBL3660107 IC50 3.0 nM
Cc1cncc(-c2nc3cc(F)cc(F)c3c(N3CC(C)(C)c4ncc(N5CCOCC5)cc43)c2C)c1 CHEMBL3698370 Ki 3.0 nM
Cc1nc(-c2cc(Cc3ccc(S(C)(=O)=O)cc3)cnc2Nc2cccc3[nH]ncc23)c2nc[nH]c2n1 CHEMBL3646450 Ki 3.0 nM
COc1ncc(Nc2ncc([C@H](C)N3CCN(S(C)(=O)=O)C[C@@H]3C)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL2170089 Ki 3.0 nM
COc1ncc(Nc2ncc(C(C)N3CCN(S(C)(=O)=O)CC3)nc2-c2cc(N)nc(C)n2)cc1F CHEMBL3646575 Ki 3.0 nM
COc1ncc(Nc2ncc([C@@H](C)N3CCN(S(C)(=O)=O)C[C@@H]3C)cc2-c2nc(C)nc3[nH]cnc23)cc1F CHEMBL3646586 Ki 3.0 nM
Cc1nc(-c2cc(C(C)N3CCOCC3)cnc2Nc2cnc(Cl)c(NS(C)(=O)=O)c2)c2nc[nH]c2n1 CHEMBL3646618 Ki 3.0 nM
COc1ncc(-c2ccc3ncc4c(c3n2)n([C@H]2CC[C@H](C(N)=O)CC2)c(=O)n4C)cn1 CHEMBL3681096 Ki 3.0 nM
Cc1ncc(-c2cc3c(C)nc(N)nc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4228112 IC50 3.0 nM
CNC(=O)[C@H](C)Cn1cnc2ccc(-c3cnc(C)c(NS(=O)(=O)c4ccc(F)cc4Cl)c3)cc2c1=O CHEMBL4643040 IC50 3.0 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1cncc(c1)-c1cnc3ccc-2nn13 CHEMBL4876703 IC50 3.0 nM
Cc1nc(NC(=O)N2CCC[C@H]2C(N)=O)sc1-c1ccnc(C(C)(C)C(F)(F)F)c1 CHEMBL2396661 IC50 3.0 nM
COc1cccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(C)=O)CC2)c(=O)n4C)c1 CHEMBL3681191 Ki 3.04 nM
CCNc1nc(C)c2cc(-c3ccc(O)c(OC)c3)c(=O)n(C3CCCC3)c2n1 CHEMBL3648923 IC50 3.08 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NC[C@@H]1CCN(C1)c1ncnc3c(C)c-2sc13 CHEMBL4866710 IC50 3.08 nM
O=S(=O)(Nc1cc(-c2ccc3ncc(NCCN4CCCCC4)nc3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914735 Ki 3.1 nM
O=S(=O)(Nc1cc(-c2ccc3nccnc3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914715 Ki 3.1 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1ccccc1-2 CHEMBL2381253 IC50 3.1 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1cnc(OC(C)(C)C(N)=O)cc1OCC2 CHEMBL3769972 Ki(app) 3.1 nM
CCc1cccc(-c2cc3c(C)nc(N)nc3n(C3CCCC3)c2=O)c1 CHEMBL3649012 IC50 3.1 nM
COc1ncc(-c2ccc3nccc(=O)n3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4284400 IC50 3.1 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3C[C@H](OCCO)C3)c2=O)cc1F CHEMBL3652270 IC50 3.11 nM
COC(=O)N1CCN(c2nc3cc(F)cc(F)c3c(N3CC4(CCOCC4)c4ncc(N5CCOCC5)cc43)c2C)CC1 CHEMBL3701666 Ki 3.11 nM
CN(C)c1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(CCO)CC2)c(=O)n4C)cn1 CHEMBL3681124 Ki 3.13 nM
Cc1c(N2CCCCC2=O)nc2cc(F)cc(F)c2c1N1CC(C)(C)c2ncc(N3CCOCC3)cc21 CHEMBL3698365 Ki 3.14 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NC[C@H]1CCN(C1)c1ncnc3c(C)c-2sc13 CHEMBL4860117 IC50 3.15 nM
CO[C@H]1CCN(c2cn3c(n2)-c2ccc(N4CCC[C@H]4C(N)=O)cc2OCC3)C1=O CHEMBL5202549 Ki 3.15 nM
CNC(=O)N1CCN(c2nc3cc(F)cc(F)c3c(N3CC4(CCOCC4)c4ncc(N5CCOCC5)cc43)c2C)CC1 CHEMBL3701684 Ki 3.16 nM
CCN1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6ccccc6c5)nc4c32)CC1 CHEMBL3681067 Ki 3.19 nM
CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)NCCN5CCN(C)CC5)cc4)cc3)nc21 CHEMBL589612 IC50 3.2 nM
CN1C2CCC1CC(Oc1nc(-c3ccc(NC(=O)Nc4ccc(C(N)=O)cc4)cc3)nc(N3CCOCC3)n1)C2 CHEMBL1808992 IC50 3.2 nM
COCCCNC(=O)c1cn2cc(-c3cnc(N)nc3)nc(N3CCOCC3)c2n1 CHEMBL2058167 IC50 3.2 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1cnc(N3CCC[C@@H]3C(N)=O)cc1OCC2 CHEMBL3769603 Ki(app) 3.2 nM
Cc1c(Cc2ccccc2)nc2cc(F)cc(F)c2c1N1CC(C)(C)c2ncc(N3CCOCC3)cc21 CHEMBL3698350 Ki 3.2 nM
CCOc1cnc(CN2CCC(c3ccc4cc(C(=O)N5CCN(Cc6ccc(C#N)cc6)CC5)n(C)c4c3)CC2)cn1 CHEMBL3955171 IC50 3.2 nM
NC(=O)c1ccc2c(c1)OCCc1sc(-c3ncnn3-c3ccc(F)cc3F)nc1-2 CHEMBL5192406 IC50 3.2 nM
COc1ncc(-c2ccc3ncc(C#N)c(N4CCOCC4)c3c2)cc1NS(C)(=O)=O CHEMBL5426067 IC50 3.2 nM
COC[C@@H]1COC(=O)N1c1cn2c(n1)-c1ccc(N3CCC[C@H]3C(N)=O)cc1OCC2 CHEMBL5176372 Ki 3.24 nM
Cc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)NN)CC2)c(=O)n4C)cn1 CHEMBL3681112 Ki 3.27 nM
COc1ncc(-c2sc3c(-c4ccc(CNC=O)s4)ncnc3c2C)cc1NS(=O)(=O)c1ccccc1 CHEMBL4851911 IC50 3.29 nM
CC(=O)Nc1nc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)cc2[nH]1 CHEMBL1822060 Ki 3.3 nM
O=S(=O)(Nc1cc(-c2ccc3ncc(NCC4CCCNC4)nc3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914733 Ki 3.3 nM
CNC(=O)c1ccc2c(c1)OCCn1cc(-c3ncnn3C(C)C)nc1-2 CHEMBL2381254 IC50 3.3 nM
CNC(=O)c1ccc2c(c1)OCCc1sc(-c3ncnn3C(C)C)nc1-2 CHEMBL2381252 IC50 3.3 nM
CN1Cc2cnc3ccc(-c4cnc(N)nc4)nc3c2N(c2cccc(C(F)(F)F)c2)C1=O CHEMBL3916654 IC50 3.3 nM
COc1ncc(-c2cc(OCCN3CCOCC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4163911 IC50 3.3 nM
COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)cc(N2CCN(C(=S)SCC(=O)NC3CCC3)CC2)n1 CHEMBL5407800 IC50 3.3 nM
Cc1c(-c2ccccn2)nc2cc(F)ccc2c1N1CC(C)(C)c2ncc(-c3ccnc(N)n3)cc21 CHEMBL2171930 Ki 3.323 nM
Cc1c(-c2ccccn2)nc2cccc(F)c2c1N1CC(C)(C)c2ncc(N3CCOCC3)cc21 CHEMBL3698307 Ki 3.327 nM
COc1ncc(-c2ccc3ncc(Cl)c(=O)n3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4288258 IC50 3.4 nM
CNC(=O)[C@H](C)Cn1cnc2ccc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4)c3)cc2c1=O CHEMBL4641876 IC50 3.4 nM
Nc1ncc(-c2nc(N3CCOCC3)nc(N3[C@@H]4CC[C@H]3COC4)n2)c(C(F)F)n1 CHEMBL4749136 Ki 3.4 nM
O=S(=O)(c1ccc(O)cc1)N1CCN(c2nc(NCCN3CCOCC3)nc(N3CCOCC3)n2)CC1 CHEMBL4789747 IC50 3.41 nM
COc1ncc(-c2ccc3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3112720 IC50 3.43 nM
COc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(C)C)CC2)c(=O)n4C)cn1 CHEMBL3681080 Ki 3.48 nM
CC(C)n1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(CO)cc4)cc3)nc21 CHEMBL600258 IC50 3.5 nM
Cc1nc(N)ncc1-c1nc(N2CCOCC2)c2sc(C(C)(C)O)cc2n1 CHEMBL1085178 IC50 3.5 nM
CN(C)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4C5CCC4COC5)n3)cc2)cc1 CHEMBL1258408 IC50 3.5 nM
Cc1nc(N)nc(-c2cc(Cl)cnc2Nc2cnc(Cl)c(NS(C)(=O)=O)c2)n1 CHEMBL2206918 Ki 3.5 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(CNCCO)ccc1-2 CHEMBL2381264 IC50 3.5 nM
Nc1nc2cc(-c3nn(CC4CCCC4)c4ncnc(N)c34)ccc2o1 CHEMBL3797933 IC50 3.5 nM
Nc1cc(C(F)(F)F)c(-c2cc(N3CCOCC3)nc(N3CCOCC3)n2)cn1 CHEMBL2017974 Kd 3.5 nM
CCNC(=O)[C@H](C)Cn1cnc2ccc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4Cl)c3)cc2c1=O CHEMBL4645263 IC50 3.5 nM
COc1ncc(-c2nc3c(N4CCCC4)ncnc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4754818 IC50 3.5 nM
O=C(CCCCCCn1cnc2c(N3CCOCC3)nc(-c3cccc(CO)c3)nc21)NO CHEMBL4749655 Kd 3.5 nM
Cc1nc2cnc3ccc(-c4cnc5[nH]ccc5c4)cc3c2n1-c1ccc(C(C)(C)C#N)nc1 CHEMBL5204586 IC50 3.5 nM
Cc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(c3ncccn3)CC2)c(=O)n4C)cn1 CHEMBL3681101 Ki 3.52 nM
Oc1cccc(-c2nc(N3CCOCC3)c3oc4ncccc4c3n2)c1 CHEMBL538346 IC50 3.6 nM
CC(C)n1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(N)=O)cc4)cc3)nc21 CHEMBL591760 IC50 3.6 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1ccccc1OCC2 CHEMBL2381255 IC50 3.6 nM
CC(=O)Nc1cn2cc(-c3cnc(N)c(C(F)(F)F)c3)ccc2n1 CHEMBL2418954 IC50 3.6 nM
COc1ncc(-c2cc3c(-c4ccncc4)ncnc3s2)cc1NS(=O)(=O)c1ccc(C#N)cc1 CHEMBL3577922 IC50 3.6 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1ccc(O[C@H](C)C(N)=O)cc1OCC2 CHEMBL3770644 Ki(app) 3.6 nM
COc1cc2c(cn1)-c1nc(-c3ncnn3C(C)C)cn1CCO2 CHEMBL3770615 Ki(app) 3.6 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@@H](OCC(N)=O)CC3)c2=O)cn1 CHEMBL2375961 IC50 3.62 nM
O=S(=O)(Nc1cncc(-c2ccc3ncc(-c4cn(CCCN5CCOCC5)nn4)n3n2)c1)c1ccc(F)cc1F CHEMBL5431132 IC50 3.62 nM
COc1ncc(-c2ccc3nccc(C#CCN(C)C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3763397 IC50 3.7 nM
Cc1nc(N)nc2c1cc(-c1cnc3[nH]ccc3c1)c(=O)n2C1CCOCC1 CHEMBL3648971 IC50 3.7 nM
Nc1ncc(-c2nc(N3CCOCC3)c3sc(CN4CCN(C(=O)c5cc(Cc6n[nH]c(=O)c7ccccc67)ccc5F)CC4)cc3n2)cn1 CHEMBL4848869 IC50 3.7 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCC1CCN(CC1)c1ncnc3ccc-2cc13 CHEMBL4850446 IC50 3.7 nM
OCCN(CCO)c1nc(N2CCOCC2)nc(-n2c(C(F)F)nc3ccccc32)n1 CHEMBL5087654 IC50 3.7 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnn2ccc(Br)cc12 CHEMBL1928525 IC50 3.8 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)N1CCc3ccc(cc3C1)-c1ccnc3ccc-2cc13 CHEMBL4874434 IC50 3.8 nM
COc1ncc(-c2ccc3ncc4[nH]c(=O)n(-c5ccc(C(C)(C)C#N)cc5)c4c3n2)cc1F CHEMBL3681058 Ki 3.81 nM
NC(=O)[C@@H]1CCCN1c1ccc2c(c1)OCCn1cc(N3CCOCCC3=O)nc1-2 CHEMBL5193496 Ki 3.82 nM
CN(C)c1ccc(-c2ccc3ncc4[nH]c(=O)n(-c5ccc(C(C)(C)C#N)cc5)c4c3n2)cn1 CHEMBL3681056 Ki 3.85 nM
COc1ccc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@@H](OCC(N)=O)CC3)c2=O)cn1 CHEMBL2375964 IC50 3.87 nM
COc1ncc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(C)=O)CC2)c(=O)n4C)cn1 CHEMBL3681117 Ki 3.87 nM
Cc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)C(C)(C)O)CC2)c(=O)n4C)cn1 CHEMBL2331665 Ki 3.89 nM
COc1ncc(-c2ccc3nccc(C#CCN(C)CCO)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3764095 IC50 3.9 nM
Cc1nc(N)nc2c1cc(-c1cccc(CO)c1)c(=O)n2C1CCOCC1 CHEMBL3639478 IC50 3.9 nM
CCn1nccc1NC(=O)c1cc2c(C)nc(N)nc2n(C(C)C)c1=O CHEMBL3652252 IC50 3.9 nM
COc1ncc(-c2cc(OCCCCCCCC(=O)NO)c3ncnc(C)c3c2)cc1NS(C)(=O)=O CHEMBL4535819 IC50 3.9 nM
Cn1c(=O)n(C2CCN(C(=O)C(C)(C)N)CC2)c2c3nc(-c4cnc5ccccc5c4)ccc3ncc21 CHEMBL3681088 Ki 3.92 nM
COc1ncc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)CN)CC2)c(=O)n4C)cn1 CHEMBL3681115 Ki 3.93 nM
COCCN(C)Cc1cc2nc(-c3cccc(O)c3)nc(N3CCOCC3)c2s1 CHEMBL493290 IC50 4.0 nM
Cc1c(CN2CCN(S(C)(=O)=O)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1091978 IC50 4.0 nM
COc1ccc2c(c1)c(/C=C1\Oc3cc(O)cc(O)c3C1=O)c(C)n2CCN1CCN(CCCO)CC1 CHEMBL1090505 IC50 4.0 nM
O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3C4COCC3[C@@H](O)C4)n2)cc1 CHEMBL1258744 IC50 4.0 nM
Cc1nc(N)nc(-n2c(Nc3cccc(O)c3)nc3ccccc32)n1 CHEMBL1762788 IC50 4.0 nM
O=S(=O)(Nc1cncc(-c2ccc3ncc(-c4ccncc4)n3c2)c1)c1ccccc1 CHEMBL1765622 IC50 4.0 nM
CCNC(=O)c1ccc2c(c1)OCCc1cc(C(=O)N(C)c3ccccc3Cl)sc1-2 CHEMBL1949922 Ki(app) 4.0 nM
CNCc1ccc2c(c1)OCCc1cc(C(=O)N(C)c3ccccc3Cl)sc1-2 CHEMBL1949923 Ki(app) 4.0 nM
CN(C(=O)c1cc2c(s1)-c1ccc(C(=O)NCCN)cc1OCC2)c1ccccc1Cl CHEMBL1949924 Ki(app) 4.0 nM
CC(C)(O)Cn1ncnc1-c1cc2c(s1)-c1ccc(C(N)=O)cc1OCC2 CHEMBL2322769 IC50 4.0 nM
CC(C)Cn1ncnc1-c1cc2c(s1)-c1ccc(C(N)=O)cc1OCC2 CHEMBL2322765 IC50 4.0 nM
CC(C)n1ncnc1-c1cc2c(s1)-c1ccc(C(N)=O)cc1OCC2 CHEMBL2322764 IC50 4.0 nM
CCN1CCN(CC(=O)Nc2ccc(-c3cccc4c(=O)cc(N5CCOCC5)oc34)c3sc4ccccc4c23)CC1 CHEMBL1086377 IC50 4.0 nM
Cn1c(=O)n(-c2ccc(C(C)(C)C#N)cc2)c2c3cc(-c4cnc5ccccc5c4)ccc3ncc21 CHEMBL1879463 IC50 4.0 nM
O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3[C@H]4COC[C@@H]3[C@H](O)C4)n2)cc1 CHEMBL3526476 Activity 4.0 nM
O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3C4COCC3C(O)C4)n2)cc1 CHEMBL3526762 Activity 4.0 nM
CC(C)(C)c1ncc2c(n1)-c1sc(NC(=O)N3CCC[C@H]3C(N)=O)nc1CC2 CHEMBL3609522 IC50 4.0 nM
CN(C)[C@@H]1C[C@@H](C(N)=O)N(C(=O)Nc2nc3c(s2)-c2nc(C(C)(C)C)ncc2CC3)C1 CHEMBL3609529 IC50 4.0 nM
CC(C)(C)c1ncc2c(n1)-c1sc(NC(=O)N3CCC[C@@]3(C)C(N)=O)nc1CC2 CHEMBL3609523 IC50 4.0 nM
C[C@@H]1CCN(C(=O)Nc2nc3c(s2)-c2nc(C(C)(C)C)ncc2CC3)[C@@H]1C(N)=O CHEMBL3609525 IC50 4.0 nM
C[C@@H]1CCN(C(=O)Nc2nc3c(s2)-c2nc(C(C)(C)C(F)(F)F)ncc2CC3)[C@@H]1C(N)=O CHEMBL3609526 IC50 4.0 nM
COCCS(=O)(=O)Nc1cc(C#Cc2c(C)ncnc2N2CCOCC2)cnc1C CHEMBL3655866 IC50 4.0 nM
Cc1ncnc(N2CCOCC2)c1C#Cc1cncc(NS(C)(=O)=O)c1 CHEMBL3655878 IC50 4.0 nM
CCc1ncnc(N2CCC(OC)CC2)c1C#Cc1cnc(C)c(NS(C)(=O)=O)c1 CHEMBL3655899 IC50 4.0 nM
Cc1nc(N)nc2c1cc(-c1ccc3c(c1)OCCO3)c(=O)n2[C@H]1CC[C@H](O)CC1 CHEMBL3649016 IC50 4.0 nM
O=S(=O)(Nc1cc(-c2cnc3ccc(N4CCOCC4)cn23)cnc1Cl)c1ccc(F)cc1 CHEMBL3649429 Ki 4.0 nM
Cc1cc2ncc(-c3cnc(Cl)c(NS(=O)(=O)N(C)C)c3)n2cc1-c1ccncc1 CHEMBL3649446 Ki 4.0 nM
Cc1nc(N)nc(-c2cc(CN3CCN(S(C)(=O)=O)CC3)cnc2Nc2cccc3[nH]ncc23)n1 CHEMBL3643923 Ki 4.0 nM
COc1ncc(Nc2ncc([C@H](C)N3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL2170099 Ki 4.0 nM
COc1ncc(Nc2ncc([C@@H](C)N3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL2170081 Ki 4.0 nM
Cc1nc(N)nc(-c2cccnc2Nc2ccc(NC(=O)Nc3cccc(F)c3)nc2)n1 CHEMBL3646518 Ki 4.0 nM
COc1ccc(Nc2ncc(C(O)c3ccc(S(=O)(=O)N(C)C)cc3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL3646543 Ki 4.0 nM
COc1ncc(Nc2nc(-c3cccnc3)ccc2-c2nc(C)nc(N)n2)cc1F CHEMBL3646557 Ki 4.0 nM
COc1ncc(Nc2ncc(C(C)(C)O)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL3357868 Ki 4.0 nM
Cc1nc(N)nc(-c2cc([C@@H](C)N3CCN(S(C)(=O)=O)C[C@@H]3C)cnc2Nc2ccc3scnc3c2)n1 CHEMBL3646584 Ki 4.0 nM
COc1ncc(Nc2ncc(C3(O)CC3)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL3357869 Ki 4.0 nM
Cc1nc(N)nc(-c2cc(CN3CCOCC3)cnc2Nc2cnc(Cl)c(NS(C)(=O)=O)c2)n1 CHEMBL2206908 Ki 4.0 nM
Cc1nc(-c2cc(C(C)N3CCOCC3)cnc2Nc2cnc(Cl)c(NS(=O)(=O)N(C)C)c2)c2nc[nH]c2n1 CHEMBL3646619 Ki 4.0 nM
COc1cnc(CN2CCC(c3ccn4nc(C(=O)N5CCN(Cc6ccc(C(F)(F)F)cc6)CC5)cc4c3)CC2)cn1 CHEMBL3941150 IC50 4.0 nM
COc1ccc(-c2ccc3ncc4c(c3c2)n(-c2ccc(N3CCNCC3)c(C(F)(F)F)c2)c(=O)n4C)cn1 CHEMBL3218578 IC50 4.0 nM
COc1ncc(-c2cc(OCCCCCCCCC(=O)NO)c3ncnc(C)c3c2)cc1NS(C)(=O)=O CHEMBL4458497 IC50 4.0 nM
C[C@H]1COCCN1c1nc(-c2cnc(N)nc2C(F)(F)F)nc(N2CCOCC2)n1 CHEMBL4472639 Ki 4.0 nM
Cc1ncccc1-c1nc2cc(F)ccc2c(N2CC(C)(C)c3ncc(N4CCOCC4)cc32)c1C CHEMBL3698291 Ki 4.071 nM
Cc1c(-c2ccccn2)nc2c(C)ccc(F)c2c1N1CC(C)(C)c2ncc(N3CCOCC3)cc21 CHEMBL3698312 Ki 4.072 nM
COc1ccc(-c2ccc3ncc4c(c3n2)n([C@@H](C)CO)c(=O)n4C)cn1 CHEMBL3681164 Ki 4.08 nM
Cc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)CN(C)C)CC2)c(=O)n4C)cn1 CHEMBL3681109 Ki 4.09 nM
CC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnn(C)c5)nc4c32)CC1 CHEMBL3681139 Ki 4.09 nM
N#Cc1cc(N)ncc1-c1cc(Nc2cnc3ccccc3c2)nc(N2CCOCC2)n1 CHEMBL2017966 IC50 4.1 nM
CNc1nc(C)c2cc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4F)c3)cc(OC3CCC3)c2n1 CHEMBL4172514 IC50 4.1 nM
C[C@H]1COCCN1c1nc(-c2cnc(N)nc2C(F)F)cc(N2CCOCC2)n1 CHEMBL4516236 Ki 4.1 nM
CNC(=O)[C@H](C)Cn1cnc2ccc(-c3cnc(OC)c(NS(=O)(=O)c4sccc4C)c3)cc2c1=O CHEMBL4637007 IC50 4.1 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1cncc(c1)-c1ncnc3sc-2cc13 CHEMBL4852833 IC50 4.1 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@H](OCC(N)=O)CC3)c2=O)cn1 CHEMBL2375956 IC50 4.11 nM
Cc1ccnc(-c2nc3cc(F)ccc3c(N3CC(C)(C)c4ncc(N5CCOCC5)cc43)c2C)c1 CHEMBL3698364 Ki 4.17 nM
Cn1c(=O)n([C@H]2CC[C@H](O)CC2)c2c3nc(-c4cn[nH]c4)ccc3ncc21 CHEMBL3681103 Ki 4.17 nM
N#Cc1ncccc1Nc1ccc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc2c1 CHEMBL3769902 IC50 4.2 nM
COc1ccc(CN2CCC(c3cc4cc(C(=O)N5CCN(Cc6ccc(C(F)(F)F)cc6)CC5)n(C)c4cn3)CC2)cn1 CHEMBL3946485 IC50 4.2 nM
Cc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C)CC2)c(=O)n4C)cn1 CHEMBL3681106 Ki 4.26 nM
COc1ccc(-c2cc3c(C)nc(N)nc3n(C3CCC(=O)CC3)c2=O)cn1 CHEMBL3648953 IC50 4.3 nM
CNC(=O)[C@H](C)Cn1cnc2ccc(-c3cnc(OC)c(NS(=O)(=O)c4c(C)noc4C)c3)cc2c1=O CHEMBL4646419 IC50 4.3 nM
C[C@H]1COCCN1c1nc(-c2ccc(NC(=O)Nc3ccc(C(=O)N4CCC(C(N)=O)CC4)cc3)cc2)nc(N2CCOCC2)n1 CHEMBL5085872 IC50 4.3 nM
NC(=O)[C@@H]1CCCN1C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4C[C@@H]5OCCO[C@H]5C4)n3)cc2)cc1 CHEMBL5078347 IC50 4.3 nM
Cc1c(-c2ccccc2)nc2ncccc2c1N1CC2(CCOCC2)c2ncc(N3CCOCC3)cc21 CHEMBL3701675 Ki 4.36 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@@H](O)CC3)c2=O)cn1 CHEMBL3652245 IC50 4.4 nM
CNC(=O)[C@H](C)Cn1cnc2ccc(-c3cnc(OC)c(NS(=O)(=O)c4cccc(C(F)(F)F)c4)c3)cc2c1=O CHEMBL4636353 IC50 4.4 nM
Nc1ncc(-c2nc(N3CCOCC3)nc(N3C[C@H]4CC[C@@H](C3)O4)n2)c(C(F)F)n1 CHEMBL4754767 Ki 4.4 nM
Nc1nc2cc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)ccc2o1 CHEMBL5170522 IC50 4.4 nM
Cn1c(=O)n([C@H]2CC[C@H](O)CC2)c2c3nc(-c4cccc5[nH]ccc45)ccc3ncc21 CHEMBL3681160 Ki 4.41 nM
Cc1c(-c2ccccc2S(C)(=O)=O)nc2cc(F)ccc2c1N1CC(C)(C)c2ccc(N3CCOCC3)cc21 CHEMBL3698299 Ki 4.434 nM
CN(C)c1ccc(-c2ccc3ncc4c(c3n2)n(-c2ccc(C(C)(C)C#N)cc2)c(=O)n4C)cn1 CHEMBL3681057 Ki 4.45 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(CCN1CCOCC1)/N=C/c1cnn2ccc(C#N)cc12 CHEMBL1928559 IC50 4.5 nM
COc1ncc(Nc2nc3ccc(C(C)(C)O)cn3c2-c2nc(C)nc(N)n2)cc1F CHEMBL3618245 IC50 4.5 nM
COc1ncc(-c2ccc3nccc(-c4ccc(C)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3985191 IC50 4.5 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n(N3CCCC3)c2=O)cc1F CHEMBL2057736 IC50 4.5 nM
COc1ncc(-c2cc3c(C)nc(NC(C)=O)nc3s2)cc1NS(C)(=O)=O CHEMBL4226683 IC50 4.5 nM
COc1ncc(-c2ccc3ncnc(NCCN4CCOCC4)c3c2)cc1NS(C)(=O)=O CHEMBL4439145 IC50 4.5 nM
Cc1c(-c2ccccc2S(C)(=O)=O)nc2cc(F)cc(F)c2c1N1CC2(CCOCC2)c2ncc(N3CCOCC3)cc21 CHEMBL3701644 Ki 4.51 nM
CC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5ccnc6ncccc56)nc4c32)CC1 CHEMBL3681170 Ki 4.51 nM
CN(C)CCNC(=O)c1cn2cc(-c3cnc(N)nc3)nc(N3CCOCC3)c2n1 CHEMBL2058164 IC50 4.6 nM
COc1ccc(-c2cc3c(C)nc(N)nc3n([C@@H]3CC[C@@H](O)C3)c2=O)cn1 CHEMBL3648938 IC50 4.6 nM
CNc1nc(C)c2cc(-c3ccc(OC)nc3)c(=O)n(CC3CCOC3)c2n1 CHEMBL3648979 IC50 4.6 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1cccc(c1)-c1ccnc3ccc-2cc13 CHEMBL4868111 IC50 4.6 nM
COc1ncc2cc1NS(=O)(=O)c1cc(c(F)cc1F)C(=O)NCc1cncc(c1)-c1ccnc3ccc-2nc13 CHEMBL4875906 IC50 4.6 nM
Cn1cc(-c2ccc3ncc4c(c3n2)n(C2CCN(CC(N)=O)CC2)c(=O)n4C)cn1 CHEMBL3681137 Ki 4.63 nM
Cc1c(-n2ccccc2=O)nc2cc(F)cc(F)c2c1N1CC2(CCOCC2)c2ccc(N3CCOCC3)cc21 CHEMBL3701645 Ki 4.64 nM
Cn1cc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)C(C)(C)O)CC2)c(=O)n4C)cn1 CHEMBL3681141 Ki 4.67 nM
CN(/N=C/c1cnn2ccc(C#N)cc12)S(=O)(=O)c1cc([N+](=O)[O-])ccc1F CHEMBL1928724 IC50 4.7 nM
COc1ncc(-c2ccc3ncc4c(c3n2)n(C2CCN(CC(=O)N(C)C)CC2)c(=O)n4C)cn1 CHEMBL3681099 Ki 4.7 nM
COc1ccc(-c2cc3c(C)nc(N)nc3n([C@H]3C[C@H](OCC(N)=O)C3)c2=O)cn1 CHEMBL3652272 IC50 4.72 nM
Nc1ncc(-c2nc3c(c(N4CCOCC4)n2)CCN(C(=O)c2cc(Cc4n[nH]c(=O)c5ccccc45)ccc2F)C3)cn1 CHEMBL4438741 pIC50 4.786 nM
Cc1c(CN2CCN(C(=O)[C@@H](C)O)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1921986 IC50 4.8 nM
COc1ncc(-c2ccc3nccc(-c4ccc(CN(C)CCO)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1 CHEMBL3911998 IC50 4.8 nM
COc1ncc(-c2cc(OC3CCN(C)CC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4159735 IC50 4.8 nM
COc1ncc(-c2cc3c(N4CCC(OC)CC4)ncnc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4779034 IC50 4.8 nM
CCc1ncnc(-c2ccc(C(=O)N3CCn4cnnc4C3)c(Cl)c2)c1C#Cc1ccc(N)nc1 CHEMBL3645926 IC50 4.83 nM
Cn1ncc2c(-c3ccc(S(C)(=O)=O)cc3)nc(-c3cccc4[nH]ncc34)nc21 CHEMBL1257652 IC50 4.9 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CCCN3)ccc1-2 CHEMBL2381267 IC50 4.9 nM
COCCNC(=O)[C@H](C)Cn1cnc2ccc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4Cl)c3)cc2c1=O CHEMBL4649866 IC50 4.9 nM
COCC(=O)N1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc(OC)nc5)nc4c32)CC1 CHEMBL3681098 Ki 4.97 nM
CCN(/C=C1/C(=O)O[C@H](COC)[C@@]2(C)C1=C(O)C(=O)C1=C2[C@H](OC(C)=O)C[C@]2(C)[C@@H](O)CC[C@@H]12)CCN(C)C CHEMBL272898 IC50 5.0 nM
CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)nc21 CHEMBL590073 IC50 5.0 nM
CC(C)n1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)nc21 CHEMBL590074 IC50 5.0 nM
Nc1ncc(-c2nc(N3CCOCC3)c3sccc3n2)cn1 CHEMBL594844 IC50 5.0 nM
CC(=O)N(C)Cc1cc2nc(-c3cnc(N)nc3)nc(N3CCOCC3)c2s1 CHEMBL1090599 IC50 5.0 nM
O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CCOCC3)c3ccn(CCO)c3n2)cc1 CHEMBL1092071 IC50 5.0 nM
COc1ccc2c(c1)c(/C=C1\Oc3cc(O)cc(O)c3C1=O)c(C)n2CCCN(C)C CHEMBL1091855 IC50 5.0 nM
COc1ccc2c(c1)c(/C=C1\Oc3cc(O)cc(O)c3C1=O)c(C)n2CCN1CCN(C)CC1 CHEMBL1090153 IC50 5.0 nM
Cc1cc(C(=O)Nc2cn[nH]c2)c2nc(C)nc(N)c2c1 CHEMBL1668279 Ki 5.0 nM
CN1CCN(Cc2cc3c(N4CCOCC4)nc(-c4cnc(N)nc4)nc3s2)CC1 CHEMBL1949913 Ki(app) 5.0 nM
CNC(=O)c1ccc2c(c1)OCCc1cc(C(=O)N(C)c3ccc(C(=O)N4CCN(C)CC4)cc3Cl)sc1-2 CHEMBL1950037 Ki(app) 5.0 nM
Cc1nc(NC(=O)N2CCC[C@H]2C(N)=O)sc1-c1ccc(-n2cccn2)cc1 CHEMBL2071338 Ki 5.0 nM
COc1ccc(Nc2ncc(C3=CCOCC3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165030 Ki 5.0 nM
C[C@@H]1CCN(C(=O)Nc2nc3c(s2)-c2cc(C(C)(C)C(F)(F)F)ncc2OC3)[C@@H]1C(N)=O CHEMBL3605177 IC50 5.0 nM
CN(C)C[C@@H]1CCN(C(=O)Nc2nc3c(s2)-c2nc(C(C)(C)C)ncc2CC3)[C@@H]1C(N)=O CHEMBL3609527 IC50 5.0 nM
C[C@@H]1CCN(C(=O)Nc2nc3c(s2)-c2nc(C(C)(C)C(F)(F)F)sc2CC3)[C@@H]1C(N)=O CHEMBL3609520 IC50 5.0 nM
COc1cc(-c2ccc3nc(NC(C)=O)cn3n2)cnc1N CHEMBL3752760 IC50 5.0 nM
C[C@@H]1CN(c2cc(=O)c3cc(C(=O)N(C)C)cc(CN(C)c4cc(F)cc(F)c4)c3o2)CCO1 CHEMBL3797698 IC50 5.0 nM
COC1(c2nc3c(N4CCOCC4)nc(-c4cnc(N)nc4)nc3n2C)COC1 CHEMBL3815084 Ki(app) 5.0 nM
CCc1nc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc2n1C CHEMBL3814365 Ki(app) 5.0 nM
COCCN(C)c1ncnc(C)c1C#Cc1cnc(C)c(NS(=O)(=O)c2ccccc2)c1 CHEMBL3660133 IC50 5.0 nM
CCCS(=O)(=O)Nc1cc(C#Cc2c(C)ncnc2N2CCOCC2)cnc1C CHEMBL3655857 IC50 5.0 nM
CCc1ncnc(N2CCN(C3CC3)CC2)c1C#Cc1cnc(C)c(NS(=O)(=O)c2ccc(F)cc2)c1 CHEMBL3655882 IC50 5.0 nM
CCc1nc(N)nc(N2CCC(O)CC2)c1C#Cc1cnc(C)c(NS(C)(=O)=O)c1 CHEMBL3655889 IC50 5.0 nM
CCc1nc(N)nc(N2CCCCC2)c1C#Cc1cnc(C)c(NS(C)(=O)=O)c1 CHEMBL3655890 IC50 5.0 nM
Cc1ncc(C#Cc2c(C)ncnc2N2CCOCC2)cc1NS(=O)(=O)C1CCCCC1 CHEMBL3655893 IC50 5.0 nM
CNc1nc(C)c2cc(C(=O)Nc3ccon3)c(=O)n(C3CCCC3)c2n1 CHEMBL3652255 IC50 5.0 nM
CS(=O)(=O)Nc1cc(-c2cnc3cc(-c4cccnc4)ccn23)cnc1Cl CHEMBL3649437 Ki 5.0 nM
COc1ccc(Nc2ncc(C(O)c3ccc(S(C)(=O)=O)cc3)cc2-c2nc(C)nc3[nH]cnc23)cn1 CHEMBL3646478 Ki 5.0 nM
COc1ccc(Nc2ncc(C(C)c3ccc(S(C)(=O)=O)cc3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL3646484 Ki 5.0 nM
Cc1nc(N)nc(-c2cccnc2Nc2cnc(Cl)c(NS(=O)(=O)c3ccc(F)cc3)c2)n1 CHEMBL2206912 Ki 5.0 nM
COCCOc1cnc(Nc2cnc(Cl)c(NS(C)(=O)=O)c2)c(-c2nc(C)nc(N)n2)c1 CHEMBL2206906 Ki 5.0 nM
Cc1nc(-c2cccnc2Nc2cnc(Cl)c(NS(C)(=O)=O)c2)c2nc[nH]c2n1 CHEMBL3646617 Ki 5.0 nM
COc1ncc(Nc2ncc(C3=CCOCC3)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL3646622 Ki 5.0 nM
COc1ncc(Nc2ncc(C3CCOCC3)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL3646623 Ki 5.0 nM
COc1ncc(Nc2ncc(CN3CCN(S(C)(=O)=O)[C@H](C)C3)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL3646634 Ki 5.0 nM
Cc1nc(N)nc(-c2cc([C@H](C)N3CCOCC3)cnc2Nc2cnc(Cl)c(NS(C)(=O)=O)c2)n1 CHEMBL3649464 Ki 5.0 nM
Cc1nc(NC(=O)N2CCC[C@@]2(C)C(N)=O)sc1-c1ccnc(C2(C(F)(F)F)CCC2)c1 CHEMBL3702863 IC50 5.0 nM
Cc1nc(N)c(-c2nc(C3CCN(C)CC3)nn2C)nc1-c1cnc2ccccn12 CHEMBL4093351 IC50 5.0 nM
COC(=O)N1CC[C@](C)(N2CCc3c(-c4cnc(N)nc4)nc(N4CCOCC4)nc32)C1 CHEMBL3963659 IC50 5.0 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCCn1cc(cn1)-c1ncnc3ccc-2cc13 CHEMBL4863609 IC50 5.0 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1cncc(c1)-c1cnn3ccc-2nc13 CHEMBL4845761 IC50 5.0 nM
FC(F)c1nc2ccccc2n1-c1nc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL586702 IC50 5.0 nM
C[C@H](NC(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOC[C@@H]4C)n3)cc2)cc1)C(N)=O CHEMBL5071085 IC50 5.0 nM
CCNC(=O)Nc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)OC(C)(C)C)CC2)c(=O)n4C)cc1 CHEMBL3681180 Ki 5.02 nM
CCNc1nc(C)c2cc(-c3ccc(OC)nc3)c(=O)n(C3CCCC3)c2n1 CHEMBL3648926 IC50 5.03 nM
O=S(=O)(Nc1cc(-c2ccc3ncccc3n2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914712 Ki 5.1 nM
COc1ncc(-c2cc(OCCCCCC(=O)NO)c3ncnc(C)c3c2)cc1NS(C)(=O)=O CHEMBL4434897 IC50 5.1 nM
COCCN(CCO)c1nc(N2CCOCC2)nc(-n2c(C(F)F)nc3ccccc32)n1 CHEMBL5078681 IC50 5.1 nM
C=CC(=O)N1CCC(C(=O)N(C)CC(=O)N2CCN(c3nc(-c4cnc(N)nc4C(F)F)nc(N4CCOCC4)n3)CC2)CC1 CHEMBL5268290 IC50 5.1 nM
COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCN(C(=S)SCC(=O)NC3CCCCC3)CC2)n1 CHEMBL5406079 IC50 5.1 nM
Cn1cc(-c2ccc3ncc4c(c3n2)n(C2CCOCC2)c(=O)n4C)cn1 CHEMBL3681129 Ki 5.17 nM
Cc1ccnc(-c2nc3cc(F)ccc3c(N3CC4(CCOCC4)c4ncc(N5CCOCC5)cc43)c2C)c1 CHEMBL3701650 Ki 5.19 nM
Cc1c(-c2cncc(F)c2)nc2cc(F)cc(F)c2c1N1CC(C)(C)c2ncc(N3CCOCC3)cc21 CHEMBL3698369 Ki 5.21 nM
COc1ncc(-c2ccc3ncc(C(=O)NCc4cn(CCCN5CCOCC5)nn4)n3n2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL5398514 IC50 5.21 nM
COc1ncc(-c2cc(Oc3ccc(/N=N\c4ccc(Oc5cc(-c6cnc(OC)c(NS(=O)(=O)c7ccc(F)cc7F)c6)cc6c(C)ncnc56)cc4)cc3)c3ncnc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL5415741 IC50 5.24 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCN(C(=O)OC(C)(C)C)C4)c3c2)cc1NS(C)(=O)=O CHEMBL4554487 IC50 5.3 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@@H](OCCO)CC3)c2=O)cn1 CHEMBL3652262 IC50 5.31 nM
Cc1c(-c2cncc(F)c2)nc2cnccc2c1N1CC(C)(C)c2ncc(N3CCOCC3)cc21 CHEMBL3701689 Ki 5.37 nM
Cc1c(-c2cccc(F)c2)nc2ncccc2c1N1CC2(CCOCC2)c2ncc(N3CCOCC3)cc21 CHEMBL3701673 Ki 5.38 nM
Cc1nc(N)nc2c1cc(-c1cnc3[nH]ccc3c1)c(=O)n2CC1CCCO1 CHEMBL3648988 IC50 5.4 nM
Cc1c(N2CCOC(C)(C)C2)nc2cc(F)cc(F)c2c1N1CC2(CCOCC2)c2ncc(N3CCOCC3)cc21 CHEMBL3701652 Ki 5.4 nM
COc1ncc(-c2cc(OC3CCOCC3)c3nc(NCC4CC4)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4163150 IC50 5.4 nM
COc1ncc(-c2ccc3ncn(CC(N)C(N)=O)c(=O)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1Cl CHEMBL4647130 IC50 5.4 nM
CS(=O)(=O)N1CCN(Cc2cc3nc(-c4ccc(N)nc4)nc(N4CCOCC4)c3s2)CC1 CHEMBL1083810 IC50 5.5 nM
CCOC(=O)N1CCN(CC#Cc2ccnc3ccc(-c4cnc(OC)c(NS(=O)(=O)c5ccc(F)cc5F)c4)cc23)CC1 CHEMBL3765587 IC50 5.5 nM
COc1ncc(-c2ccc3ncn(C[C@@H](C)C(=O)NCC(F)(F)F)c(=O)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1Cl CHEMBL4632381 IC50 5.5 nM
NC(=O)[C@@H]1CC(O)CN1C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL5084675 IC50 5.5 nM
Cc1c(N2CCCCC2=O)nc2cc(F)cc(F)c2c1N1CC2(CCOCC2)c2ncc(N3CCOCC3)cc21 CHEMBL3701640 Ki 5.51 nM
Nc1nc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)cc2s1 CHEMBL1822052 Ki 5.6 nM
Cc1nc(N)nc(-c2c(Nc3cccc4[nH]ncc34)nc3ccccn23)n1 CHEMBL3618237 Ki 5.6 nM
COc1ncc(-c2cc3c(C)nc(N)nc3s2)cc1NS(=O)(=O)C1CC1 CHEMBL4228422 IC50 5.6 nM
Nc1cc(C(F)(F)F)c(-c2nc3c(c(N4CCOCC4)n2)CCN(C(=O)c2cc(Cc4n[nH]c(=O)c5ccccc45)ccc2F)C3)cn1 CHEMBL4470724 pIC50 5.623 nM
CN(C)c1ccnc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)cc12 CHEMBL1914719 Ki 5.7 nM
COc1ncc(Nc2nc3ccc(N4CCNCC4)cn3c2-c2nc(C)nc(N)n2)cc1F CHEMBL3618238 Ki 5.7 nM
COc1ncc(-c2ccc3ncn(CC4(C(N)=O)CC4)c(=O)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1Cl CHEMBL4647937 IC50 5.7 nM
NC(=O)[C@H]1CCCN1C(=O)c1ccc(NC(=O)Nc2ccc(-c3cc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL5083425 IC50 5.7 nM
NC(=O)[C@@H]1CCCN1c1ccc2c(c1)OCCn1cc(N3CCOC3=O)nc1-2 CHEMBL5205873 Ki 5.75 nM
COc1ccc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@H](OCC(N)=O)CC3)c2=O)cn1 CHEMBL2375958 IC50 5.79 nM
NC(=O)c1cccc2cc(C(=O)N3CCN(c4nc(-c5cnc(N)nc5)nc(N5CCOCC5)n4)CC3)oc12 CHEMBL4744783 IC50 5.8 nM
CC(C)c1c(-c2ccccn2)nc2cc(F)ccc2c1N1CC(C)(C)c2ncc(N3CCOCC3)cc21 CHEMBL3698289 Ki 5.868 nM
Oc1cc(O)cc(-c2nc(N3CCOCC3)c3oc4ncccc4c3n2)c1 CHEMBL3109178 IC50 5.9 nM
Cc1nc(N)nc2c1cc(-c1ccc(N(C)C)nc1)c(=O)n2[C@H]1CC[C@H](O)CC1 CHEMBL3648967 IC50 5.9 nM
COC(=O)Nc1cc(C(F)(F)F)c(-c2nc(N3CCOCC3)c3cc(CN4CCN(S(C)(=O)=O)CC4)cn3n2)cn1 CHEMBL4800252 IC50 5.9 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3C[C@H](OCC(N)=O)C3)c2=O)cn1 CHEMBL3652274 IC50 5.91 nM
CN1CCC(n2c(=O)n(C)c3cnc4ccc(-c5cnc6ccccc6c5)nc4c32)CC1 CHEMBL3681076 Ki 5.92 nM
COc1ncc(-c2cc3c(C)nc(N)cc3n(C3CCCC3)c2=O)cc1F CHEMBL3112724 IC50 5.95 nM
Cc1cc2nc(-c3cccc(O)c3)nc(N3CCOCC3)c2s1 CHEMBL493083 IC50 6.0 nM
COC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(NC(=O)Nc5ccc(CO)cc5)cc4)nc32)CC1 CHEMBL558955 IC50 6.0 nM
O=C(Nc1ccc(C(=O)O)cc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1 CHEMBL597824 IC50 6.0 nM
O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CCOCC3)c3nnn(C4CC4)c3n2)cc1 CHEMBL590325 IC50 6.0 nM
CCCCNC(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)c4nnn(CC)c4n3)cc2)cc1 CHEMBL589412 IC50 6.0 nM
CN(C)C1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)c5ccn(CC(F)(F)F)c5n4)cc3)cc2)CC1 CHEMBL1092401 IC50 6.0 nM
COc1ccc2c(c1)c(/C=C1\Oc3cc(O)cc(O)c3C1=O)c(C)n2CCCN1CCN(CCO)CC1 CHEMBL1093449 IC50 6.0 nM
Cc1nc(N)c2cccc(C(=O)Nc3cn[nH]c3)c2n1 CHEMBL1667869 Ki 6.0 nM
Nc1ncc(Nc2cc(-c3cnc(N)nc3)nc(N3CCOCC3)n2)cn1 CHEMBL1672329 IC50 6.0 nM
CNC(=O)Nc1ccc(Nc2nc3ccccc3n2-c2nc(C)nc(N)n2)cc1 CHEMBL1760154 IC50 6.0 nM
Cc1nc(N)cc2c1cc(-c1cnc3[nH]ncc3c1)c(=O)n2C1CCCC1 CHEMBL3112728 IC50 6.0 nM
CN(C)CC(=O)N1CCC(c2cc(-c3cnc(N)c(-n4nnc5ccccc54)n3)n(C)n2)CC1 CHEMBL3590225 IC50 6.0 nM
CC(C)(C)c1ncc2c(n1)-c1sc(NC(=O)N3CC[C@@H]4C[C@@]43C(N)=O)nc1CC2 CHEMBL3609524 IC50 6.0 nM
COCCOc1cc(-c2ccc3nc(NC(C)=O)cn3n2)cnc1N CHEMBL3751961 IC50 6.0 nM
C[C@@H]1CN(c2cc(=O)c3cc(C(=O)N(C)C)cc(CN4CCOc5c(F)cccc54)c3o2)CCO1 CHEMBL3798914 IC50 6.0 nM
Cc1ncc(C#Cc2c(C)ncnc2NC(C)C)cc1NS(=O)(=O)c1ccccc1 CHEMBL3639589 IC50 6.0 nM
CNc1nc(C)c2cc(-c3cn[nH]c3)c(=O)n(CC3CCOC3)c2n1 CHEMBL3648978 IC50 6.0 nM
O=S(=O)(Nc1cc(-c2cnc3ccc(Br)cn23)cnc1Cl)c1ccc(F)cc1 CHEMBL3649426 Ki 6.0 nM
COc1ccc(Nc2ncc(C(C)N3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc3[nH]cnc23)cn1 CHEMBL3646479 Ki 6.0 nM
COc1ccc(Nc2ncc([C@@H](C)N3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL3649478 Ki 6.0 nM
COc1ccc(Nc2ncc(-c3ccccn3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL3646502 Ki 6.0 nM
COc1ccc(Nc2ncc(CN3CCN(S(C)(=O)=O)CC3)cc2-c2cc(N)nc(C)n2)cn1 CHEMBL3646507 Ki 6.0 nM
COc1ccc(Nc2ncc(CN3CC(S(C)(=O)=O)C3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL3646535 Ki 6.0 nM
COc1ncc(Nc2ncc(C(C)(C)N3CCOCC3)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL3646573 Ki 6.0 nM
COc1ncc(Nc2ncc(C(N3CCN(S(C)(=O)=O)CC3)C(F)(F)F)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL3646612 Ki 6.0 nM
Cc1nc(N)nc(-c2cccnc2Nc2cnc(Cl)c(NS(=O)(=O)C3CC3)c2)n1 CHEMBL2206914 Ki 6.0 nM
Cc1nc(N)nc(-c2cc([C@@H](C)N3CCOCC3)cnc2Nc2cnc(Cl)c(NS(=O)(=O)N(C)C)c2)n1 CHEMBL3649465 Ki 6.0 nM
CNC(=O)c1nc(-c2nc(-c3cnc4ccccn34)c(C)nc2N)n(C)n1 CHEMBL4072637 IC50 6.0 nM
O=c1cc(N2CCOCC2)nc2n1CC[C@@H](C(F)(F)F)N2C[C@@H](O)c1ccccc1 CHEMBL4517404 IC50 6.0 nM
CCc1ncc(-c2ccc3ncn(C[C@@H](C)C(=O)NC)c(=O)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1Cl CHEMBL4637855 IC50 6.0 nM
O=C(O)c1ccc(CNc2nc3ccc(-c4nc(N5CCOCC5)nc(N5CCOCC5)n4)cc3o2)cc1 CHEMBL5174517 IC50 6.0 nM
COc1ccc(-c2ccc3nc(C)c(-c4cnc(N)c(C(F)(F)F)c4)n3n2)cc1OC CHEMBL5282271 IC50 6.0 nM
CC(=O)Nc1cn2nc(-c3cnc(Cl)c(NS(=O)(=O)N4CCOCC4)c3)ccc2n1 CHEMBL5281874 IC50 6.0 nM
Cc1ccc(S(=O)(=O)N2CCN(c3nc(NCCN4CCOCC4)nc(N4CCOCC4)n3)CC2)cc1 CHEMBL4792033 IC50 6.03 nM
CO[C@@H](C)Cn1c(=O)n(C)c2cnc3ccc(-c4cncc(C(C)(C)O)c4)cc3c21 CHEMBL4297181 IC50 6.07 nM
COc1ncc(-c2ccc3ncc4c(c3n2)n(-c2ccc(C(C)(C)C#N)cc2)c(=O)n4C)cn1 CHEMBL3681061 Ki 6.09 nM
O=S(=O)(Nc1cc(-c2ccc3nccn3n2)cnc1Cl)c1ccc(F)cc1 CHEMBL1822056 Ki 6.1 nM
COc1ncc(Nc2nc3ccc(N4CCN(C(=O)N(C)C)CC4)cn3c2-c2nc(C)nc(N)n2)cc1F CHEMBL3618243 Ki 6.1 nM
COc1ncc(-c2cc3c(C)nc(N)nc3[nH]c2=O)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4226663 IC50 6.1 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1cc(ccn1)-c1ccnc3ccc-2cc13 CHEMBL4852466 IC50 6.1 nM
CO[C@H]1CC[C@H](n2c(=O)c(-c3ccc(N(C)C)nc3)cc3c(C)nc(N)nc32)CC1 CHEMBL3648959 IC50 6.2 nM
CCOc1cnc(CN2CCC(c3ccc4c(c3)cc(C(=O)N3CCN(Cc5ccc(C#N)cc5)CC3)n4C)CC2)cn1 CHEMBL3895006 IC50 6.2 nM
COc1ncc(-c2ccc3ncn(C[C@@H](C)C(=O)NC4CC4(F)F)c(=O)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1Cl CHEMBL4636770 IC50 6.2 nM
COc1ncc2cc1NS(=O)(=O)c1ccc(Cl)c(c1)C(=O)NCc1ccc(s1)-c1ncnc3cc-2sc13 CHEMBL4854225 IC50 6.28 nM
COCCN1CCN(c2ccc3nc(Nc4cnc(OC)c(F)c4)c(-c4nc(C)nc(N)n4)n3c2)CC1 CHEMBL3618241 Ki 6.3 nM
COc1ncc(-c2nc3c(N4CC5CCCC5C4)ncnc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4747503 IC50 6.3 nM
COc1ncc2cc1NS(=O)(=O)c1ccc(F)c(c1)C(=O)NCc1ccc(s1)-c1ncnc3cc-2sc13 CHEMBL4854645 IC50 6.34 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C(O)CO)ccc1-2 CHEMBL2381262 IC50 6.4 nM
COc1ncc(-c2cc3c(C)nc(N)cc3n(C3CCCC3)c2=O)cn1 CHEMBL3112723 IC50 6.45 nM
Cc1c(-c2ccccn2)nc2cc(F)ccc2c1N1CC(C)(C)c2ncc(C3=CCOCC3)cc21 CHEMBL3698359 Ki 6.47 nM
Cc1c(-c2ccccn2)nc2cccc(F)c2c1N1CC2(CCOCC2)c2ncc(N3CCOCC3)cc21 CHEMBL3701642 Ki 6.48 nM
C[C@H]1CN(c2cn3c(n2)-c2ccc(N4CCC[C@H]4C(N)=O)cc2OCC3)C(=O)O1 CHEMBL5173962 Ki 6.49 nM
O=C(Nc1ccc(F)cc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)cc1 CHEMBL599246 IC50 6.5 nM
Cn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4cccs4)cc3)nc21 CHEMBL589600 IC50 6.5 nM
COc1ccc(-c2cc(CNc3ccc(S(=O)(=O)Nc4nnc(C)s4)cc3)cc(C(=O)NCCc3ccccc3F)c2)cn1 CHEMBL3582350 IC50 6.5 nM
COc1ncc(Nc2nc3ccc(N4CCN(C(C)C)CC4)cn3c2-c2nc(C)nc(N)n2)cc1F CHEMBL3618240 Ki 6.5 nM
COc1ccc(-c2cc3c(C)nc(N)nc3n(C3CCOCC3)c2=O)cn1 CHEMBL3218404 IC50 6.6 nM
CNc1nc(C)c2cc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4F)c3)cc(OC3CCCC3)c2n1 CHEMBL4168064 IC50 6.6 nM
COc1ncc(-c2cn3c(C(=O)NCCc4ccccc4)cnc3cn2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL5402186 IC50 6.63 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3C[C@H](OCCO)C3)c2=O)cn1 CHEMBL3652271 IC50 6.65 nM
Cc1nc(N)nc2c1cc(-c1cn[nH]c1)c(=O)n2[C@H]1CC[C@H](O)CC1 CHEMBL3648935 IC50 6.7 nM
CNC(=O)c1cccc(S(=O)(=O)Nc2cc(-c3sc4c(-c5cccs5)ncnc4c3C)cnc2OC)c1 CHEMBL4874628 IC50 6.72 nM
Cc1c(-c2ccccn2)nc2cc(F)ccc2c1N1CC(C)(C)c2ncc(N3CCOCC3)cc21 CHEMBL2171929 Ki 6.759 nM
CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)NCCc5ccccn5)cc4)cc3)nc21 CHEMBL590357 IC50 6.8 nM
Cn1ncc2c(Oc3ccc(S(C)(=O)=O)cc3)cc(-c3cccc4[nH]ncc34)nc21 CHEMBL1257653 IC50 6.8 nM
CC(C)=CC(=O)CCC(=O)N1CCN(Cc2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL2316958 IC50(app) 6.8 nM
C[C@H]1COCCN1c1nc(-c2cnc(N)cc2C(F)(F)F)nc(N2CCOC[C@@H]2C)n1 CHEMBL4515950 Ki 6.8 nM
CC(C)(C)OC(=O)N1CC[C@](C)(N2CCc3c(-c4cnc(N)nc4)nc(N4CCOCC4)nc32)C1 CHEMBL3901131 IC50 6.8 nM
COc1ccc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@H](OC[C@@H](O)CO)CC3)c2=O)cn1 CHEMBL3652266 IC50 6.82 nM
COc1ncc(-c2cnc3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(Cl)s1 CHEMBL3327146 IC50 6.87 nM
COc1cc(-c2nc3cc(F)cc(F)c3c(N3CC4(CCOCC4)c4ncc(N5CCOCC5)cc43)c2C)ccn1 CHEMBL3701651 Ki 6.89 nM
COc1ncc(-c2ccc3ncn(C[C@@H](C)C(=O)NC(C)C)c(=O)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1Cl CHEMBL4632947 IC50 6.9 nM
CCC(Cn1cnc2ccc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4Cl)c3)cc2c1=O)C(N)=O CHEMBL4636828 IC50 6.9 nM
CC(C)C(=O)N1CC[C@](C)(N2CCc3c(-c4cnc(N)nc4)nc(N4CCOCC4)nc32)C1 CHEMBL3920965 IC50 6.9 nM
COc1ccc2cc1C(=O)NCc1ccc(s1)-c1ncnc3cc(sc13)-c1cnc(OC)c(c1)NS2(=O)=O CHEMBL4866896 IC50 6.91 nM
OCCN1CCN(Cc2cc3nc(-c4cccc(O)c4)nc(N4CCOCC4)c3s2)CC1 CHEMBL522031 IC50 7.0 nM
CC(C)(N)c1cc2nc(-c3cnc(N)nc3)nc(N3CCOCC3)c2s1 CHEMBL1090600 IC50 7.0 nM
O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CCOCC3)c3ccn(CCN4CCNCC4)c3n2)cc1 CHEMBL1092280 IC50 7.0 nM
COc1ccc2c(c1)c(/C=C1\Oc3cc(O)cc(O)c3C1=O)c(C)n2C CHEMBL1089653 IC50 7.0 nM
O=C(Nc1ccc(CO)cc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3C4CCC3COC4)n2)cc1 CHEMBL1258183 IC50 7.0 nM
Cc1cc(C(=O)Nc2ccn[nH]2)c2nc(C)nc(N)c2c1 CHEMBL1668266 Ki 7.0 nM
CNc1ncc(-c2cc(Nc3cnc4ccccc4c3)nc(N3CCOCC3)n2)cn1 CHEMBL1672324 IC50 7.0 nM
O=S(=O)(Nc1cncc(-c2ccc3ncc(-c4cccnc4)n3c2)c1)c1ccccc1 CHEMBL1765621 IC50 7.0 nM
C/C(=N\NS(=O)(=O)c1cc([N+](=O)[O-])ccc1C)c1cnn2ccc(C#N)cc12 CHEMBL1928547 IC50 7.0 nM
NC(=O)c1ccc2c(c1)OCCc1cc(-c3ncnn3CC(F)(F)F)sc1-2 CHEMBL2322770 IC50 7.0 nM
CN(C(=O)c1cc2c(s1)-c1ncccc1OCC2)c1ccccc1Cl CHEMBL2322772 IC50 7.0 nM
Nc1ncc(-c2nc(N3CCOCC3)c3ncccc3n2)cn1 CHEMBL3109134 IC50 7.0 nM
Cn1c(=O)n(-c2ccc(C3(C#N)CC3)cc2)c2c3cc(-c4cnc5ccccc5c4)ccc3ncc21 CHEMBL3354566 IC50 7.0 nM
COc1cncc(-c2ccc3nc(NC(=O)NCC(=O)NCC(F)(F)F)sc3c2)c1 CHEMBL3356895 Ki 7.0 nM
COc1ncc(-c2ccc3nc(NC(=O)NC4CC4)nn3c2)cc1NS(=O)(=O)c1ccc(F)cc1 CHEMBL3601923 IC50 7.0 nM
Cc1nc(NC(=O)N2CCC[C@H]2C(N)=O)sc1-c1ccnc(C(C)(C)C)n1 CHEMBL2397186 IC50 7.0 nM
C[C@@H]1CN(c2cc(=O)c3cc(C(=O)N(C)C)cc(CN4CCOc5c(F)cc(F)cc54)c3o2)CCO1 CHEMBL3797812 IC50 7.0 nM
COc1ccc(Nc2ncc(CN3CCN(S(=O)(=O)N(C)C)CC3)cc2-c2nc(C)nc3[nH]cnc23)cn1 CHEMBL3646435 Ki 7.0 nM
Cc1nc(N)nc(-c2cc(CN3CCN(S(C)(=O)=O)CC3)cnc2Nc2ccc3ocnc3c2)n1 CHEMBL3646468 Ki 7.0 nM
COc1ccc(Nc2ncc(C(C)N3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL3646482 Ki 7.0 nM
COc1ccc(Nc2ncc(CN3CCN(S(C)(=O)=O)C[C@H]3C)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL3646490 Ki 7.0 nM
CNc1nc(C)nc(-c2cc(CN3CCN(S(C)(=O)=O)CC3)cnc2Nc2ccc(OC)nc2)n1 CHEMBL3646493 Ki 7.0 nM
COc1ccc(Nc2ncc(C3(N4CCN(S(C)(=O)=O)CC4)CC3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL3646574 Ki 7.0 nM
COc1ncc(Nc2ncc(CN3CCN(S(C)(=O)=O)CC3C(F)(F)F)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL3646603 Ki 7.0 nM
COc1cnc(Nc2cnc(Cl)c(NS(C)(=O)=O)c2)c(-c2nc(C)nc(N)n2)c1 CHEMBL2206903 Ki 7.0 nM
COc1ncc(Nc2ncc(CN3CCN(S(C)(=O)=O)C[C@@H]3C(F)(F)F)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL3646602 Ki 7.0 nM
Cc1nc(N)nc(-c2cc([C@@H](C)N3CCOCC3)cnc2Nc2cnc(Cl)c(NS(C)(=O)=O)c2)n1 CHEMBL3649463 Ki 7.0 nM
COc1ncc(Nc2ncc(CN3CCN4C(CCS4(=O)=O)C3)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL3649474 Ki 7.0 nM
CCn1nc(C2CCN(C(=O)CCO)CC2)nc1-c1cnc(N)c(-c2nnc(C(C)(C)C)o2)n1 CHEMBL3894518 IC50 7.0 nM
COc1ncc(-c2ccc3ncnc(NCCN(C)C)c3c2)cc1NS(C)(=O)=O CHEMBL4227195 IC50 7.0 nM
COc1ncc(-c2ccc3ncnc(NC4CCN(C(=O)OC(C)(C)C)CC4)c3c2)cc1NS(C)(=O)=O CHEMBL4470588 IC50 7.0 nM
Cc1c(CN2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)cc3C(F)(F)F)nc12 CHEMBL4875356 IC50 7.0 nM
CN(C)[C@@H]1C[C@@H](C(N)=O)N(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)nc(N5CCOCC5)n4)cc3)cc2)C1 CHEMBL5079231 IC50 7.0 nM
COc1ncc(-c2ccc3ncnc(NCCN4CCOCC4)c3c2)cc1NS(=O)(=O)C1CC1 CHEMBL4441829 IC50 7.1 nM
Nc1nc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)cc2o1 CHEMBL1822211 Ki 7.2 nM
COc1ncc(-c2cc3c(N4CCOCC4)ncnc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4745332 IC50 7.2 nM
COc1ncc(-c2cc3c(N4CC(OC)C4)ncnc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4799097 IC50 7.2 nM
COc1ncc(-c2cn3c(-c4cn(CCN(C)C)nn4)cnc3cn2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL5403717 IC50 7.2 nM
Clc1ccccc1-n1cnnc1-c1cc2c(s1)-c1ccccc1OCC2 CHEMBL2322773 IC50 7.3 nM
Nc1ncc(-c2cc(Nc3cnc4ccccc4c3)nc(N3CCOCC3)n2)c(=O)[nH]1 CHEMBL2017969 IC50 7.4 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1sc(cc1C)-c1ncnc3cc-2sc13 CHEMBL4868086 IC50 7.4 nM
Cn1cc(-c2ccc3ncc4c(c3n2)n([C@H]2CC[C@H](O)CC2)c(=O)n4C)cn1 CHEMBL3681105 Ki 7.44 nM
COc1ncc(-c2cn3c(-c4cn(CCN5CCN(C)CC5)nn4)cnc3cn2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL5407573 IC50 7.46 nM
COc1ccc(-c2cc3c(C)nc(N)nc3n(C3CCOC3)c2=O)cn1 CHEMBL3218405 IC50 7.5 nM
Cc1nc(NC(=O)[C@@H](C)N)sc1-c1cncc(NS(=O)(=O)c2ccccc2)c1 CHEMBL4169244 IC50 7.5 nM
COc1ncc(-c2cn3c(C(=O)NCc4cn(CCN5CCOCC5)nn4)cnc3cn2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL5429174 IC50 7.53 nM
Cc1nc(N)nc2c1cc(-c1c[nH]cn1)c(=O)n2[C@H]1CC[C@H](OCCO)CC1 CHEMBL3652259 IC50 7.58 nM
COc1ccc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@@H](O)CC3)c2=O)cn1 CHEMBL3218403 IC50 7.6 nM
COc1ccc(CN2CCC(c3ccc4nc(C(=O)N5CCN(Cc6ccc(C(F)(F)F)cc6)CC5)[nH]c4c3)CC2)cc1 CHEMBL3892677 IC50 7.6 nM
Cc1c(N2CCCC2=O)nc2cc(F)ccc2c1N1CC2(CCOCC2)c2ncc(N3CCOCC3)cc21 CHEMBL3701658 Ki 7.64 nM
COc1ccc(-c2cc3c(C)nc(N)nc3n(CC3CCOC3)c2=O)cn1 CHEMBL3648983 IC50 7.7 nM
COc1ncc(-c2ccc3ncnc(N(C)CCN(C)C)c3c2)cc1NS(C)(=O)=O CHEMBL4456355 IC50 7.7 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCCn1cc(cn1)-c1cnn3ccc-2nc13 CHEMBL4875243 IC50 7.7 nM
COc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(C)=O)CC2)c(=O)n4C)cc1 CHEMBL3681189 Ki 7.71 nM
Cc1c(-c2ccccn2)nc2cc(F)ccc2c1N1CC2(CS(=O)(=O)C2)c2ccc(N3CCOCC3)cc21 CHEMBL2171924 Ki 7.75 nM
O=C(OCc1ccccc1)C1CCC(n2c(=O)[nH]c3cnc4ccc(-c5cnc6ccccc6c5)nc4c32)CC1 CHEMBL3681064 Ki 7.77 nM
COc1ccc(-c2ccc3ncc4c(c3n2)n(CCN2CCNCC2)c(=O)n4C)cn1 CHEMBL3681181 Ki 7.8 nM
Nc1ccc(-c2ccc3ncc4c(=O)[nH]c(=O)n(-c5cccc(C(F)(F)F)c5)c4c3n2)cn1 CHEMBL3903725 IC50 7.8 nM
COc1cnc(CN2CCC(c3ccc4c(c3)cc(C(=O)N3CCN(Cc5ccc(C#N)cc5)CC3)n4C)CC2)cn1 CHEMBL3983813 IC50 7.8 nM
Cc1c(-c2ccccc2S(C)(=O)=O)nc2cc(F)ccc2c1N1CC(C)(C)c2ncc(N3CCOCC3)cc21 CHEMBL3698302 Ki 7.801 nM
COc1ncc(-c2cnc3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1cccnc1 CHEMBL3327147 IC50 7.82 nM
CC(=O)Nc1nc2ccc(-c3cnc(N)c(C(F)(F)F)c3)cc2s1 CHEMBL2418948 IC50 7.9 nM
COc1ccc(-c2nc(N3CCOCC3)c3sc(CN(C)c4ncc(C(=O)NO)cn4)cc3n2)cn1 CHEMBL3622533 IC50 7.9 nM
CN(C1CCN(Cc2cc3nc(-c4cnc(N)nc4)nc(N4CCOCC4)c3s2)C1)S(C)(=O)=O CHEMBL4534127 pIC50 7.943 nM
CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccnc(C)c4)cc3)nc21 CHEMBL590577 IC50 8.0 nM
CN(C)CCn1ccc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)nc21 CHEMBL1092841 IC50 8.0 nM
COc1ccc2c(c1)c(/C=C1\Oc3cc(O)cc(O)c3C1=O)c(C)n2CCCN1CCOCC1 CHEMBL1092189 IC50 8.0 nM
O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3C4CCC3COC4)n2)cc1 CHEMBL1258517 IC50 8.0 nM
c1ccc2ncc(Nc3cc(-c4cncnc4)nc(N4CCOCC4)n3)cc2c1 CHEMBL1672321 IC50 8.0 nM
Cc1nc(N)ncc1-c1cc(Nc2cnc3ccccc3c2)nc(N2CCOCC2)n1 CHEMBL2016592 IC50 8.0 nM
COc1ccc(Nc2ncc(-c3cnn(C)c3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165033 Ki 8.0 nM
COc1ccc(Nc2ncc(-c3ccc(C)nc3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165032 Ki 8.0 nM
NC(=O)c1ccc2c(c1)OCCc1cc(-c3ncnn3C3CCC3)sc1-2 CHEMBL2322766 IC50 8.0 nM
CC(C)(C)c1nc2c(s1)CCc1nc(NC(=O)N3CCC[C@@]3(C)C(N)=O)sc1-2 CHEMBL3609516 IC50 8.0 nM
COCCOc1nc(-c2ccc3nc(NC(C)=O)cn3c2)cnc1N CHEMBL3753085 IC50 8.0 nM
CCc1ncnc(N(C)C)c1C#Cc1cnc(C)c(NS(C)(=O)=O)c1 CHEMBL3655886 IC50 8.0 nM
Cc1ncc(C#Cc2c(C)ncnc2N(C)CC2CCOC2)cc1NS(=O)(=O)c1ccccc1 CHEMBL3660115 IC50 8.0 nM
COCCN(C)c1cc(C(=O)O)nc2c(-c3cccc(CO)c3)nc(N3CCOCC3)nc12 CHEMBL3693680 IC50 8.0 nM
CNc1nc(C)c2cc(-c3cn[nH]c3)c(=O)n(C3CCCC3)c2n1 CHEMBL3648916 IC50 8.0 nM
Cc1nc(N)nc(-c2cc(CN3CCN(S(C)(=O)=O)CC3)cnc2Nc2cccc(O)c2)n1 CHEMBL3643920 Ki 8.0 nM
COc1ccc(Nc2ncc([C@H](C)N3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL3646483 Ki 8.0 nM
COc1ncc(Nc2ncc(CN3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2170095 Ki 8.0 nM
Cc1nc(N)nc(-c2cc(CN3CCN(S(C)(=O)=O)CC3)cnc2Nc2ccc3scnc3c2)n1 CHEMBL3646546 Ki 8.0 nM
Cc1nc(N)nc(-c2cc(CN3CCN(S(C)(=O)=O)CC3)cnc2Nc2cc(F)cc3[nH]ncc23)n1 CHEMBL3646550 Ki 8.0 nM
COc1ncc(Nc2ncc(C(C)(C)CO)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL3357872 Ki 8.0 nM
Cc1nc(N)nc(-c2cc(C(C)N3CCOCC3)cnc2Nc2cnc(Cl)c(NS(C)(=O)=O)c2)n1 CHEMBL3646636 Ki 8.0 nM
CC(C)(c1cc(-c2cnc(NC(=O)N3CCC[C@@]3(C)C(N)=O)s2)ccn1)C(F)(F)F CHEMBL3702880 IC50 8.0 nM
Cc1nc(N)c(-c2cnn(C3CCN(C)CC3)n2)nc1-c1cnc2ccccn12 CHEMBL4064039 IC50 8.0 nM
C[C@@H](Nc1c(C(N)=O)cnc2ccc(-c3cccnc3)cc12)c1ccc(Cl)cc1 CHEMBL4565988 IC50 8.0 nM
COc1ncc(-c2ccc3ncn(C[C@@H](C)C(=O)NCC(C)C)c(=O)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1Cl CHEMBL4640237 IC50 8.0 nM
CS(=O)(=O)N1CCN(Cc2nc3c(N4CCOCC4)nc(-c4cnc(N)nc4)cn3c2Br)CC1 CHEMBL2087491 IC50 8.1 nM
COc1ccc(CN2CCC(c3ccc4nc(C(=O)N5CCN(Cc6ccc(C(F)(F)F)cc6F)CC5)[nH]c4c3)CC2)cn1 CHEMBL3986674 IC50 8.1 nM
Nc1ncc(-c2nc(C3=CCOCC3)nc(N3CCOCC3)n2)c(C(F)F)n1 CHEMBL5437258 Ki 8.1 nM
Cc1nc(NC(=O)N2C[C@H](Nc3ccc(C(=O)NO)cn3)C[C@H]2C(N)=O)sc1-c1ccnc(C(C)(C)C(F)(F)F)c1 CHEMBL5422044 IC50 8.1 nM
Cc1c(CCc2ccccc2)nc2cc(F)cc(F)c2c1N1CC(C)(C)c2ncc(N3CCOCC3)cc21 CHEMBL3698356 Ki 8.121 nM
COc1ncc(-c2ccc3ncc4c(c3n2)n(C2CCNCC2)c(=O)n4C)cn1 CHEMBL3681118 Ki 8.15 nM
COc1ccc(-c2cc3c(C)nc(N)nc3n(C3CCC3)c2=O)cn1 CHEMBL2057727 IC50 8.2 nM
Cc1nc(N)nc2c1cc(-c1cnc3ccccc3c1)c(=O)n2[C@H]1CC[C@H](O)CC1 CHEMBL3652244 IC50 8.2 nM
Cc1nc(NC(=O)[C@@H](N)CO)sc1-c1cnc(Cl)c(NS(=O)(=O)c2ccccc2)c1 CHEMBL4160179 IC50 8.2 nM
CC(=O)N1CCN(c2nc(N3CCOCC3)nc(-n3c(C(F)F)nc4ccccc43)n2)CC1 CHEMBL4125884 IC50 8.2 nM
CS(=O)(=O)N1CCN(Cc2cc3nc(-c4ccc(NC(=O)Nc5ccncc5)cc4)nc(N4CC5CCC(C4)O5)c3s2)CC1 CHEMBL594431 IC50 8.3 nM
CN1CCC(Nc2nc(-c3cccc4[nH]ncc34)nc3c2cnn3C)CC1 CHEMBL1257420 IC50 8.3 nM
COc1ccc(Nc2nc3ccc(N4CCN(C(=O)N(C)C)CC4)cn3c2-c2nc(C)nc(N)n2)cn1 CHEMBL3618242 Ki 8.3 nM
C[C@H]1COCCN1c1nc(-c2cnc(N)cc2C(F)(F)F)nc(N2CCOCC2)n1 CHEMBL4457600 Ki 8.3 nM
O=C(NO)c1ccc(/C=N/NC(=O)c2cc(N3CCOCC3)nc(-c3cccc4[nH]ncc34)n2)cc1 CHEMBL5182686 IC50 8.34 nM
COC[C@H]1OC(=O)/C(=C/N(C)CCN(C)C)C2=C(O)C(=O)C3=C([C@H](OC(C)=O)C[C@]4(C)[C@@H](O)CC[C@@H]34)[C@]21C CHEMBL409427 IC50 8.4 nM
COc1ncc(-c2ccc3ncn(C[C@@H](C)C(=O)NC4CCC4)c(=O)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1Cl CHEMBL4641605 IC50 8.4 nM
CNC(=O)[C@H](C)Cn1cnc2ccc(-c3cnc(N(C)C)c(NS(=O)(=O)c4ccc(F)cc4Cl)c3)cc2c1=O CHEMBL4636153 IC50 8.4 nM
COc1ncc(-c2cnc3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(C(F)(F)F)cc1 CHEMBL3327007 IC50 8.41 nM
COc1ccc(-c2cc(CNc3ccc(S(=O)(=O)Nc4nnc(C)s4)cc3)cc(C(=O)O)c2)cn1 CHEMBL3582354 IC50 8.5 nM
COc1ccc(CN2CCC(c3ccc4c(c3)nc(C(=O)N3CCN(Cc5ccc(C(F)(F)F)cc5)CC3)n4C)CC2)cn1 CHEMBL3895466 IC50 8.5 nM
Oc1cccc(-c2nc(N3CCOCC3)nc3c2CCN3c2ccncc2)c1 CHEMBL1684985 IC50 8.6 nM
Cc1nc(N)nc(-c2cc(Cl)cnc2Nc2cnc(Cl)c(NS(=O)(=O)N3CCOCC3)c2)n1 CHEMBL2206902 Ki 8.6 nM
COc1ncc(-c2cc3c(C)nc(N)cc3n(C3CCOCC3)c2=O)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3112713 IC50 8.6 nM
COc1ccc(-c2ccc3ncc4c(c3n2)N(c2ccc(N3CCNCC3)c(C(F)(F)F)c2)C(=O)N(C)C4)cn1 CHEMBL3903068 IC50 8.6 nM
CN(C)c1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(CC(F)(F)F)CC2)c(=O)n4C)cn1 CHEMBL3681092 Ki 8.78 nM
COc1ncc(-c2nc3c(N4CCCCC4)ncnc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4789380 IC50 8.8 nM
Cc1ccnc(-c2nc3cc(F)cc(F)c3c(N3CC4(CCOCC4)c4ncc(N5CCOCC5)cc43)c2C)c1 CHEMBL3701639 Ki 8.82 nM
CNc1nc(C)c2cc(-c3ccc(OC)nc3)c(=O)n(CCC3CC3)c2n1 CHEMBL3648994 IC50 8.9 nM
COc1ccc(CN2CCC(c3ccc4nc(C(=O)N5CCN(Cc6ccc7c(c6)OC(F)(F)O7)CC5)[nH]c4c3)CC2)cn1 CHEMBL3916942 IC50 8.9 nM
O=c1cc(N2CCOCC2)oc2c(-c3ccccc3)cccc12 CHEMBL98350 INH 8.9 nM
COc1ccc(S(=O)(=O)N2CCN(c3nc(NCCN4CCOCC4)nc(N4CCOCC4)n3)CC2)cc1 CHEMBL4799656 IC50 8.9 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1cncc(c1)Cc1cnc3sc-2nn13 CHEMBL4846573 IC50 8.9 nM
COc1ccc(-c2ccc3ncc4c(c3n2)n([C@H](C)CO)c(=O)n4C)cn1 CHEMBL3681157 Ki 8.94 nM
COc1ncc(-c2ccc3ncc4c(c3n2)n(C2CCOCC2)c(=O)n4C)cn1 CHEMBL3681127 Ki 8.96 nM
COc1ccc2c(c1)c(/C=C1\Oc3cc(O)cc(O)c3C1=O)c(C)n2CCN(C)C CHEMBL1090478 IC50 9.0 nM
COc1ccc(S(=O)(=O)Nc2cncc(-c3ccc4nc(NC(C)=O)sc4c3)n2)cc1 CHEMBL1773600 Ki 9.0 nM
Nc1ncc(-c2nc(N3CCOCC3)c3ccsc3n2)cn1 CHEMBL1949912 Ki(app) 9.0 nM
COc1ccc(Nc2ncc(CC3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165020 Ki 9.0 nM
COc1ccc(Nc2ncc(CN3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165017 Ki 9.0 nM
Cc1csc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL2178615 IC50 9.0 nM
COc1ccc(-c2ccc3ncc(-c4ccc(C(N)=O)cc4)n3n2)cc1OC CHEMBL3355068 IC50 9.0 nM
O=C(Nc1ccncc1)Nc1ccc(-c2nc(N3CCOCC3)nc(N3[C@@H]4COC[C@H]3[C@@H](O)C4)n2)cc1 CHEMBL3526617 Activity 9.0 nM
CC(C)(C)c1nc2c(s1)CCc1nc(NC(=O)N3CC[C@@H]4C[C@@]43C(N)=O)sc1-2 CHEMBL3609517 IC50 9.0 nM
C[C@@H]1CN(c2cc(=O)c3cc(C(=O)N(C)C)cc(CN4CCOc5ccc(F)cc54)c3o2)CCO1 CHEMBL3799511 IC50 9.0 nM
COCCN(C)c1cc(C(=O)O)nc2c(-c3cccc(F)c3O)nc(N3CCOCC3)nc12 CHEMBL3693666 IC50 9.0 nM
CO[C@H]1CC[C@H](n2c(=O)c(-c3cn[nH]c3)cc3c(C)nc(N)nc32)CC1 CHEMBL3648960 IC50 9.0 nM
COc1ncc(Nc2ncc(CN3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL2170096 Ki 9.0 nM
COc1ccc(CN(Cc2ccc(OC)cc2)c2nc(C)nc(Cl)n2)cc1 CHEMBL3643930 Ki 9.0 nM
COc1ccc(Nc2cnc(Nc3ccc(OC)nc3)c(-c3nc(C)nc4[nH]cnc34)c2)cc1 CHEMBL3646437 Ki 9.0 nM
CC(=O)Nc1ccc(Nc2ncc(Cc3ccc(S(C)(=O)=O)cc3)cc2-c2nc(C)nc3[nH]cnc23)cn1 CHEMBL3646451 Ki 9.0 nM
COc1cncc(Nc2ncc(CN3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)c1 CHEMBL2170098 Ki 9.0 nM
COc1ncc(Nc2ncc(C(OC(=O)c3cccc(Cl)c3)C(C)(C)O)cc2-c2nc(C)nc(N)n2)cc1F CHEMBL3646628 Ki 9.0 nM
Cc1nc(NC(=O)N2CCC[C@@]2(C)C(N)=O)sc1-c1ccnc(C2(C(F)(F)F)CC2)c1 CHEMBL3702861 IC50 9.0 nM
O=c1oc2ccccc2c2nn(CN3CCN(S(=O)(=O)c4ccc(Cl)c([N+](=O)[O-])c4)CC3)cc12 CHEMBL4468039 IC50 9.0 nM
CC[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(CCCCCC(=O)NO)c2c(=O)n1-c1ccccc1 CHEMBL4443378 IC50 9.0 nM
COc1ncc(-c2cn3c(-c4cn(CCN5CCOCC5)nn4)cnc3cn2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL5401801 IC50 9.01 nM
CN(C)[C@H]1C[C@@H](C(N)=O)N(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)nc(N5CCOCC5)n4)cc3)cc2)C1 CHEMBL5071429 IC50 9.1 nM
COc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCN(C(=S)SCCN3CCN(C)CC3)CC2)n1 CHEMBL5425104 IC50 9.1 nM
Cc1nc(N)nc2c1cc(-c1ccc(N(C)C)nc1)c(=O)n2[C@H]1CC[C@H](OCCO)CC1 CHEMBL3652261 IC50 9.28 nM
COc1cnc(Nc2cnc(Cl)c(NS(=O)(=O)N(C)C)c2)c(-c2nc(C)nc(N)n2)c1 CHEMBL2206904 Ki 9.3 nM
Cc1ncc(-c2cc3c(C)nc(N)nc3s2)cc1NS(=O)(=O)c1ccc(F)cc1 CHEMBL4227076 IC50 9.3 nM
Cc1nc(N)nc2c1cc(-c1ccc(OC(C)C)nc1)c(=O)n2[C@H]1CC[C@H](O)CC1 CHEMBL3648963 IC50 9.4 nM
Cc1c(-c2ccccn2)nc2cc(F)cc(F)c2c1N1CC2(CCOCC2)c2ncc(N3CCOCC3)cc21 CHEMBL3701641 Ki 9.44 nM
CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4cccnc4)cc3)nc21 CHEMBL589103 IC50 9.5 nM
CC(C)(c1cc(-c2cnc(NC(=O)N3CCC[C@H]3C(N)=O)s2)ccn1)C(F)(F)F CHEMBL2397196 IC50 9.5 nM
Cc1nc(N)nc2c1cc(-c1cn[nH]c1)c(=O)n2[C@@H]1CC[C@@H](O)C1 CHEMBL3648945 IC50 9.5 nM
CO[C@H]1CC[C@H](n2c(=O)c(-c3cc[nH]n3)cc3c(C)nc(N)nc32)CC1 CHEMBL1614778 IC50 9.5 nM
CS(=O)(=O)N1CCN(Cc2csc3c(-c4cnc(N)nc4)nc(N4CCOCC4)nc23)CC1 CHEMBL3970288 IC50 9.5 nM
COC[C@H]1OC(=O)/C(=C/N(CCCN(C)C)C(C)(C)C)C2=C(O)C(=O)C3=C([C@H](OC(C)=O)C[C@]4(C)[C@@H](O)CC[C@@H]34)[C@]21C CHEMBL272816 IC50 9.6 nM
COc1ccc(-c2cc(CNc3ccc(S(=O)(=O)Nc4nnc(C)s4)cc3)cc(C(=O)NCCC(C)C)c2)cn1 CHEMBL3582351 IC50 9.6 nM
COc1ccc(-c2ccc3ncc4c(c3n2)N(C2CCN(C(=O)[C@@H](C)O)CC2)C(=O)N(C)C4)cn1 CHEMBL4112318 IC50 9.7 nM
Cc1c(-c2ccccn2)nc2cc(F)ccc2c1N1CC(C)(C)c2ccc(-c3ccnc(N)n3)cc21 CHEMBL2171927 Ki 9.774 nM
CNc1nc(C)c2cc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4F)c3)cc(OC3CCCCC3)c2n1 CHEMBL4175917 IC50 9.8 nM
Cc1c(-c2ccccn2)nc2cc(F)ccc2c1N1CC2(CCOCC2)c2ncc(N3CCOCC3)cc21 CHEMBL2171931 Ki 9.877 nM
COc1ncc(-c2cc3c(C)nc(N)cc3n([C@H]3CC[C@H](O)CC3)c2=O)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3112712 IC50 9.9 nM
OCCNc1nc(N2CCOCC2)nc(-n2c(C(F)F)nc3ccccc32)n1 CHEMBL5094393 IC50 9.9 nM