COc1ncc(-c2ccc3nccc(-c4ccnnc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL1236962 Ki 0.02 nM
Cc1c(Cl)cccc1Cn1c(SCC(=O)O)nc(=O)c2sc(N3CCOCC3)nc21 CHEMBL2089119 IC50 0.05 nM
Cc1c(Cl)cccc1Cn1c(CO)nc(=O)c2sc(N3CCOCC3)nc21 CHEMBL2089114 IC50 0.1 nM
CC(Nc1cc(F)cc(F)c1)c1cc(C(=O)NCCN(C)C)cc2ncc(N3CCOCC3)nc12 CHEMBL4127116 Kd 0.1 nM
Cc1nc(N)nc(-n2c(Nc3cc(O)cc(O)c3)nc3ccccc32)n1 CHEMBL1762790 IC50 0.2 nM
Cc1c(Cl)cccc1Cn1c(N)nc(=O)c2sc(N3CCOCC3)nc21 CHEMBL2089120 IC50 0.2 nM
Cc1c(Cn2c(CO)nc(=O)c3sc(N4CCOCC4)nc32)cccc1C(F)(F)F CHEMBL2089112 IC50 0.2 nM
C[C@@H]1CN(C(=O)c2cc(C3CCCN3c3cc(F)cc(F)c3)c3nc(N4CCOCC4)cnc3c2)C[C@H](C)N1 CHEMBL4125781 Kd 0.2 nM
C[C@@H](Nc1cc(F)cc(F)c1)c1cc(C(=O)NCCN(C)C)cc2ncc(N3CCOCC3)nc12 CHEMBL4128507 Kd 0.2 nM
CNCCNC(=O)c1cc(C(C)Nc2cccc(F)c2)c2nc(N3CCOCC3)cnc2c1 CHEMBL4127425 Kd 0.2 nM
Cc1c(F)cccc1NCc1cc(C(=O)NCCN(C)C)cc2ncc(N3CCOCC3)nc12 CHEMBL4127570 Kd 0.2 nM
Cc1c(Cn2c(C)nn3c(=O)cc(N4CCOC(C)C4)nc23)cccc1C(F)(F)F CHEMBL2018222 IC50 0.3 nM
CSc1nc(=O)c2sc(N3CCOCC3)nc2n1Cc1cccc(Cl)c1C CHEMBL2089118 IC50 0.3 nM
COc1nc(=O)c2sc(N3CCOCC3)nc2n1Cc1cccc(Cl)c1C CHEMBL2089116 IC50 0.3 nM
CN(C)C(=O)c1cc([C@H]2CCCN2c2cc(F)cc(F)c2)c2nc(N3CCOCC3)cnc2c1 CHEMBL4130282 Kd 0.3 nM
Oc1cc(N2CCOCC2)nc2c(Cc3cccc(Cl)c3Cl)c(C(F)(F)F)nn12 CHEMBL2322340 pIC50 0.3981 nM
Cc1nn2c(O)cc(N3CCOCC3)nc2c1Cc1cccc(C(F)(F)F)c1C CHEMBL2322331 pIC50 0.3981 nM
CSc1nn2c(=O)cc(N3CCOCC3)nc2n1Cc1cccc(C(F)(F)F)c1C CHEMBL2018220 IC50 0.4 nM
C[C@H]1CN(c2cc(=O)c3cc(C(=O)N(C)C)cc([C@@H](C)Nc4cc(F)cc(F)c4)c3o2)CCO1 CHEMBL3408270 IC50 0.4 nM
Cc1nc2c(N)cc(N3CCOCC3)nn2c1Nc1cccc(C(F)(F)F)c1CN1CCN(C)CC1 CHEMBL3956037 Kd 0.4 nM
COc1ncc(-c2cc(O[C@@H]3CCOC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4176771 IC50 0.4 nM
Cc1c(Cn2c(C3CC3)nc(=O)c3sc(N4CCOCC4)nc32)cccc1C(F)(F)F CHEMBL2089109 IC50 0.5 nM
CCc1nc(=O)c2sc(N3CCOCC3)nc2n1Cc1cccc(C(F)(F)F)c1C CHEMBL2089108 IC50 0.5 nM
Cc1c(Cl)cccc1Cn1c(C)nc(=O)c2sc(N3CCOCC3)nc21 CHEMBL2089107 IC50 0.5 nM
CCN1CCN(CC(=O)Nc2ccc(-c3cccc4c(=O)cc(N5CCOCC5)oc34)c3sc4ccccc4c23)CC1 CHEMBL1086377 IC50 0.5 nM
Cc1nc2c(N)cc(N3CCOCC3)nn2c1Cc1cccc(F)c1C1CCNCC1 CHEMBL5268567 IC50 0.5 nM
COc1ncc(-c2cc(OC3CCOCC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4166144 IC50 0.53 nM
COc1ncc(-c2cc(OC3CCOCC3)c3ncnc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4527563 IC50 0.54 nM
COc1ncc(-c2ccc3ncc(-c4nnc(CCN5CCN(C)CC5)o4)n3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4440406 IC50 0.58 nM
Cc1c(Cn2c(C)nn3c(=O)cc(N4CCOCC4)nc23)cccc1C(F)(F)F CHEMBL2018219 IC50 0.6 nM
Cc1c(Cn2c(C)nc(=O)c3sc(N4CCOCC4)nc32)cccc1C(F)(F)F CHEMBL2089106 IC50 0.6 nM
Cc1nc(N)nc(-c2cc(Cl)cnc2Nc2cnc(Cl)c(NS(=O)(=O)N(C)C)c2)n1 CHEMBL2206921 Ki 0.6 nM
O=C1NC(=O)/C(=C/c2ccc3nccc(-c4ccncc4)c3c2)S1 CHEMBL3544966 IC50 0.6 nM
CCc1nn2c(O)cc(-c3ccncc3)nc2c1Cc1cccc(Cl)c1Cl CHEMBL2322338 pIC50 0.631 nM
COc1ncc(-c2ccc3nccc(/C(C)=C/C(=O)N4CCN(C)CC4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4739883 IC50 0.67 nM
Oc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL1910998 IC50 0.68 nM
COc1cc(F)c2[nH]c(-c3c(C)nn(C)c3C)c(/C=C3/Oc4ccc(NC(=O)Nc5ccc(C(=O)N(C)CCN(C)C)cc5)cc4C3=O)c2c1 CHEMBL1082621 IC50 0.7 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1ccc(N)nc1 CHEMBL3962159 IC50 0.7 nM
CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1ccc(N)nc1 CHEMBL3957355 IC50 0.8 nM
Oc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)cc(N2CCOCC2)n1 CHEMBL1911122 IC50 0.81 nM
Cc1c(Cn2c(C)nc3c(C(=O)O)cc(N4CCOCC4)cc32)cccc1C(F)(F)F CHEMBL3188551 IC50 0.89 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CNC3)ccc1-2 CHEMBL2381265 IC50 0.9 nM
CNc1cc(OC)c2nc(C(F)F)n(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)c2c1 CHEMBL1911118 IC50 0.91 nM
Cc1c(Cn2c(C)cn3c(=O)cc(N4CCOCC4)nc23)cccc1C(F)(F)F CHEMBL1957857 IC50 1.0 nM
Cc1c(Cn2ccn3c(=O)cc(N4CCO[C@H](C)C4)nc23)cccc1C(F)(F)F CHEMBL1957870 IC50 1.0 nM
CSc1nn2c(=O)cc(N3CCOC(C)C3)nc2n1Cc1cccc(C(F)(F)F)c1C CHEMBL2018360 IC50 1.0 nM
Cc1nn2c(O)cc(N3CCOCC3)nc2c1Cc1cccc2ccccc12 CHEMBL2322332 pIC50 1.0 nM
O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)N1CCc2c(Br)cccc21 CHEMBL3112850 IC50 1.0 nM
O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)N1CCc2c(Cl)cccc21 CHEMBL3112849 IC50 1.0 nM
C[C@@H](Nc1cc(F)cc(Cl)c1)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3408252 IC50 1.0 nM
CC(Nc1cccc(F)c1)c1cc(C(=O)NCCN(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656387 IC50 1.0 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(Cl)ccc(Cl)c2c(=O)n1-c1ccc(N)nc1 CHEMBL3899696 IC50 1.0 nM
CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1cnc(N)cc1C CHEMBL3943356 IC50 1.0 nM
Cc1cc(N)ncc1-n1c([C@H](C)Nc2nc(N)nc(N)c2C#N)nc2cccc(Cl)c2c1=O CHEMBL3934385 IC50 1.0 nM
O=C(NC1=Nc2ccccc2C2=NCCN12)c1cccnc1 CHEMBL4532985 IC50 1.0 nM
CC(Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1 CHEMBL5272007 IC50 1.0 nM
COc1ncc(-c2ccc3nccc(-c4ccc(CN(C)CCO)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3905146 IC50 1.1 nM
O=C(c1cc([C@H]2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1)N1CCOCC1 CHEMBL4060768 IC50 1.1 nM
CNc1nc(C)c2cc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4F)c3)cc(O[C@@H]3CCOC3)c2n1 CHEMBL4174909 IC50 1.1 nM
COc1ncc(-c2ccc3ncc(-c4cn(CCCN5CCOCC5)nn4)n3n2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL5395998 IC50 1.13 nM
Cc1c(Cc2c(CO)nc3c(N)cc(N4CCOCC4)nn23)cccc1C(F)(F)F CHEMBL3894812 Kd 1.2 nM
Cc1c(Cc2c(CO)nc3c(C(=O)O)cc(N4CCOCC4)nn23)cccc1C(F)(F)F CHEMBL3974658 Kd 1.2 nM
CN(C)C(=O)c1cc(C2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1 CHEMBL4094771 IC50 1.2 nM
CN(C)C(=O)c1cc([C@H]2CCCN2c2cccc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1 CHEMBL4078233 IC50 1.2 nM
CNc1nc(C)c2cc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4F)c3)cc(OC3CCOCC3)c2n1 CHEMBL4166594 IC50 1.2 nM
COc1ncc(-c2cc3c(C)nc(N)nc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4226082 IC50 1.2 nM
COc1nn2c(O)cc(-c3ccncc3)nc2c1Cc1cccc(Cl)c1Cl CHEMBL2322344 pIC50 1.259 nM
CC(=O)Nc1nc(C)c(-c2cnc(Cl)c(NS(=O)(=O)c3ccccc3)c2)s1 CHEMBL4174132 IC50 1.28 nM
Cc1nn2c(=O)cc(N3CCOCC3)nc2n1Cc1cccc(Cl)c1Cl CHEMBL2018214 IC50 1.3 nM
Cc1c(Cn2c(C3CC3)nn3c(=O)cc(N4CCOCC4)nc23)cccc1C(F)(F)F CHEMBL2018221 IC50 1.3 nM
Cc1nn2c(=O)cc(N3CCOC(C)C3)nc2n1Cc1cccc(Cl)c1Cl CHEMBL2018217 IC50 1.3 nM
Cc1c(Nc2c(CO)nc3c(N)cc(N4CCOC(CO)C4)nn23)cccc1C(F)(F)F CHEMBL3928423 Kd 1.3 nM
CN(C)C(=O)c1cc(C2CCCN2c2cc(F)cc(F)c2)c2nc(N3CCOCC3)cnc2c1 CHEMBL4129062 IC50 1.35 nM
COc1cc(N)cc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL1911117 IC50 1.4 nM
Cc1nc2c(C(=O)O)cc(N3CCOCC3)nn2c1Cc1cccc(C(F)(F)F)c1C CHEMBL3970860 Kd 1.4 nM
Cc1c(Cc2c(CNCCS(C)(=O)=O)nc3c(N)cc(N4CCOCC4)nn23)cccc1C(F)(F)F CHEMBL3916621 Kd 1.4 nM
O=C(c1cc([C@H]2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1)N1CC1 CHEMBL4101005 IC50 1.4 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(-c4ccc(N5CCOCC5)nc4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4872728 IC50 1.54 nM
Cc1c(Cl)cccc1Cn1c(C)nc2c(C(=O)O)cc(N3CCOCC3)nc21 CHEMBL2431396 pIC50 1.585 nM
CSc1nn2c(=O)cc(N3CCOCC3)nc2n1Cc1cccc(Cl)c1Cl CHEMBL2018215 IC50 1.6 nM
COc1c(OC[C@H](O)CN(C)C)ccc2c1N=C(NC(=O)c1cccnc1)N1CCN=C21 CHEMBL3639435 IC50 1.6 nM
COc1ccc(-c2cc3c(C)nc(N)nc3n(C3CCC(OCCO)CC3)c2=O)cn1 CHEMBL5278357 Ki 1.6 nM
Oc1cccc(-c2nc(N3CCOCC3)c3oc4ncccc4c3n2)c1 CHEMBL573339 Kd 1.7 nM
COc1ncc(-c2ccc3nccc(-c4ccc(Cn5cncn5)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3968925 IC50 1.7 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(-c4ccncc4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4864419 IC50 1.7 nM
CC(C)n1nc(N)nc1-c1nc2c(s1)CCOc1cc(-c3cnn(CCO)c3)ccc1-2 CHEMBL2381382 IC50 1.8 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3cnn(CS(C)(=O)=O)c3)ccc1-2 CHEMBL2381375 IC50 1.8 nM
COc1ncc(-c2ccc3nccc(-c4ccc(CN(C)C)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3963018 IC50 1.8 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(Cl)ccc(Cl)c2c(=O)n1-c1cnc(N)cn1 CHEMBL3954098 IC50 1.8 nM
Cc1nc2c(N)cc(N3CCOCC3)nn2c1Nc1cccc(C(F)(F)F)c1CN1CC(O)C1 CHEMBL3955003 Kd 1.9 nM
COc1c(OC[C@H](O)CN2CCCC2)ccc2c1N=C(NC(=O)c1cncnc1)N1CCN=C21 CHEMBL3644667 IC50 1.99 nM
CC(=O)Nc1nc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)cc2s1 CHEMBL1615189 Ki 2.0 nM
Cc1cn2c(=O)cc(N3CCOCC3)nc2n1Cc1cccc(Cl)c1Cl CHEMBL1957856 IC50 2.0 nM
CCc1cn2c(=O)cc(N3CCOCC3)nc2n1Cc1cccc(C(F)(F)F)c1C CHEMBL1957858 IC50 2.0 nM
CC1CN(c2cc(=O)n3ccn(Cc4cccc(Cl)c4Cl)c3n2)CCO1 CHEMBL1957866 IC50 2.0 nM
Cc1c(Cn2c(C)nn3c(=O)nc(N4CCOCC4)cc23)cccc1C(F)(F)F CHEMBL2018361 IC50 2.0 nM
O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)Nc1ccc(F)c(Cl)c1 CHEMBL2151926 IC50 2.0 nM
COc1ccc(Nc2ncc(Cc3ccc(S(C)(=O)=O)cc3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165007 Ki 2.0 nM
C[C@H]1Cc2ccccc2N1C(=O)Cc1nc(N2CCOCC2)cc(=O)[nH]1 CHEMBL3112866 IC90 2.0 nM
CC(Nc1cccc(F)c1)c1cc(C(=O)NCCN(C)C)cn2c(=O)cc(N3CCOCC3)nc12 CHEMBL3319646 IC50 2.0 nM
C[C@@H](Nc1cc(F)cc(F)c1)c1cc(C(=O)N2CCC2)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3408262 IC50 2.0 nM
CC(Nc1cc(F)cc(F)c1)c1cc(C(=O)N2CCCC2)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3408263 IC50 2.0 nM
C[C@@H]1CN(c2cc(=O)c3cc(C(=O)N(C)C)cc(CN4CCOc5c(F)cccc54)c3o2)CCO1 CHEMBL3798914 IC50 2.0 nM
C[C@@H]1CN(c2cc(=O)c3cc(C(=O)N(C)C)cc(CN(C)c4cc(F)cc(F)c4)c3o2)CCO1 CHEMBL3797698 IC50 2.0 nM
CC(=O)NCc1nc2c(-c3cnc[nH]3)cc(N3CCOCC3)nn2c1Cc1cccc(C(F)(F)F)c1C CHEMBL3903747 Kd 2.0 nM
CC(Nc1ccc(F)cc1)c1cc(C(=O)NCCN(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656386 IC50 2.0 nM
CC(Nc1ccccc1)c1cc(C(=O)NCCN(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656388 IC50 2.0 nM
CCN(C)C(=O)c1cc(C(C)Nc2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1 CHEMBL3408258 IC50 2.0 nM
CC(Nc1cc(F)c(F)c(F)c1)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656402 IC50 2.0 nM
N#Cc1c(N)nc(N)nc1N[C@H](c1nc2cccc(Cl)c2c(=O)n1-c1ccc(N)nc1)C1CC1 CHEMBL3911944 IC50 2.0 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1cnc(N)cn1 CHEMBL3913858 IC50 2.0 nM
CN(CCO)C(=O)c1cc(C2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1 CHEMBL4067312 IC50 2.0 nM
O=S(=O)(Nc1cc(-c2cnc3[nH]cc(-c4ccncc4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4217725 IC50 2.0 nM
O=S(=O)(Nc1cc(-c2cnc3[nH]cc(-c4ccncc4)c3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL4208385 IC50 2.0 nM
COc1c(OC[C@H](O)CN2CCCCC2)ccc2c1N=C(NC(=O)c1cccnc1)N1CCN=C21 CHEMBL3644671 IC50 2.02 nM
CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL521851 Kd 2.1 nM
COc1ccc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@H](OCCO)CC3)c2=O)cn1 CHEMBL1234354 Ki 2.1 nM
COc1c(OC[C@H](O)CN2CCC2)ccc2c1N=C(NC(=O)c1cccnc1)N1CCN=C21 CHEMBL3644664 IC50 2.22 nM
CN1CCN(C(=O)c2cc([C@H]3CCCN3c3cc(F)cc(F)c3)c3oc(N4CCOCC4)cc(=O)c3c2)CC1 CHEMBL4082650 IC50 2.3 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(-n4ccnc4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4871213 IC50 2.39 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3cnn(CCN)c3)ccc1-2 CHEMBL2381376 IC50 2.4 nM
Cc1c(Cc2c(CN(C)CCS(C)(=O)=O)nc3c(N)cc(N4CCOCC4)nn23)cccc1C(F)(F)F CHEMBL3897548 Kd 2.4 nM
O=c1cc(N2CCOCC2)nc2n(Cc3cccc(Cl)c3Cl)c(C3CC3)nn12 CHEMBL2018216 IC50 2.5 nM
Oc1cc(-c2ccncc2)nc2c(Cc3cccc(Cl)c3Cl)c(C(F)(F)F)nn12 CHEMBL2322341 pIC50 2.512 nM
Cc1c(Cc2cnn3c(O)cc(-c4ccncc4)nc23)cccc1C(F)(F)F CHEMBL2322337 pIC50 2.512 nM
Cc1nn2c(O)cc(N3CCOC(C)C3)nc2c1Cc1cccc(C(F)(F)F)c1C CHEMBL2322335 pIC50 2.512 nM
Cc1nc2c(-c3cnc[nH]3)cc(N3CCOCC3)nn2c1Nc1cccc(C(F)(F)F)c1C CHEMBL3946307 Kd 2.6 nM
COc1c(OC[C@H](O)CN2CCCC2)ccc2c1N=C(NC(=O)c1cccnc1)N1CCN=C21 CHEMBL3644665 IC50 2.62 nM
COc1c(OC[C@H](O)CN2CCCCC2)ccc2c1N=C(NC(=O)c1cccnc1C)N1CCN=C21 CHEMBL3644673 IC50 2.78 nM
O=C(c1cc([C@H]2CCCN2c2cccc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1)N1CCOCC1 CHEMBL4090811 IC50 2.8 nM
COc1c(OC[C@H](O)CN2CCOCC2)ccc2c1N=C(NC(=O)c1cccnc1)N1CCN=C21 CHEMBL3644648 IC50 2.98 nM
COc1c(OC[C@H](O)CN2CCCCC2)ccc2c1N=C(NC(=O)c1cncs1)N1CCN=C21 CHEMBL3644678 IC50 2.98 nM
COc1ncc(-c2ccc3ncnc(Nc4cnn(CCO)c4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4780201 IC50 2.99 nM
Oc1cccc(-c2nc(N3CCOCC3)c3oc4ncccc4c3n2)c1 CHEMBL538346 IC50 3.0 nM
O=c1cc(N2CCOCC2)nc2n(Cc3cccc4ccccc34)ccn12 CHEMBL1957841 IC50 3.0 nM
Cc1c(Cn2ccn3c(=O)cc(N4CCOCC4)nc23)cccc1C(F)(F)F CHEMBL1957855 IC50 3.0 nM
Cc1cc(C(C)Nc2ccccc2)c2nc(N3CCOCC3)cc(=O)n2c1 CHEMBL1972466 IC50 3.0 nM
Cc1cc(C(C)Nc2ccccc2)c2oc(N3CCOCC3)cc(=O)c2c1 CHEMBL2064328 IC50 3.0 nM
Cc1c(Cn2c(CN)nc(=O)c3sc(N4CCOCC4)nc32)cccc1C(F)(F)F CHEMBL2089113 IC50 3.0 nM
Cc1c(Cn2c(Cc3ccccc3)nc(=O)c3sc(N4CCOCC4)nc32)cccc1C(F)(F)F CHEMBL2089111 IC50 3.0 nM
Cc1c(Cl)cccc1Cn1cnc(=O)c2sc(N3CCOCC3)nc21 CHEMBL2089105 IC50 3.0 nM
Cc1c(Cn2cnc(=O)c3sc(N4CCOCC4)nc32)cccc1C(F)(F)F CHEMBL2089104 IC50 3.0 nM
COc1cc(NC(=O)Cc2nc(N3CCOCC3)cc(=O)[nH]2)ccc1F CHEMBL2151927 IC50 3.0 nM
COc1ccc(Nc2ncc(C3=CCOCC3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165030 Ki 3.0 nM
Cc1nc(N)nc(-c2cccnc2Nc2cccc(O)c2)n1 CHEMBL2165052 Ki 3.0 nM
Cc1cccc2c1CCN2C(=O)Cc1nc(N2CCOCC2)cc(=O)[nH]1 CHEMBL3112851 IC50 3.0 nM
CC1Cc2c(Br)cccc2N1C(=O)Cc1nc(N2CCOCC2)sc1C(N)=O CHEMBL3125395 IC50 3.0 nM
C[C@@H](Nc1cc(F)cc(F)c1)c1cc(C(=O)N(C)C)cn2c(=O)cc(N3CCOCC3)nc12 CHEMBL3319490 IC50 3.0 nM
C[C@@H](Nc1cc(F)cc(F)c1)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3408248 IC50 3.0 nM
CNC(=O)c1cc([C@@H](C)Nc2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1 CHEMBL3408267 IC50 3.0 nM
C[C@@H]1CN(c2cc(=O)c3cc(C(=O)N(C)C)cc(CN4CCOc5ccc(F)cc54)c3o2)CCO1 CHEMBL3799511 IC50 3.0 nM
C[C@@H]1CN(c2cc(=O)c3cc(C(=O)N(C)C)cc(CN4CCOc5c(F)cc(F)cc54)c3o2)CCO1 CHEMBL3797812 IC50 3.0 nM
Cc1nc2c(-c3cnc[nH]3)cc(N3CCOCC3)nn2c1Nc1cccc(C(F)(F)F)c1CN1CC(O)C1 CHEMBL3983623 Kd 3.0 nM
CC(Nc1cc(F)cc(F)c1)c1cc(C(=O)N2CCC(O)CC2)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3408266 IC50 3.0 nM
CC(Nc1cc(F)cc(F)c1)c1cc(C(=O)NCC2CC2)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656441 IC50 3.0 nM
CC(Nc1cc(F)cc(Cl)c1)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656404 IC50 3.0 nM
Cc1cc(N)ncc1-n1c([C@H](C)Nc2nc(N)nc(N)c2C#N)nc2c(Cl)ccc(Cl)c2c1=O CHEMBL3921986 IC50 3.0 nM
CCC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1ccc(N)nc1 CHEMBL3956754 IC50 3.0 nM
N#Cc1c(N)nc(N)nc1N[C@H](c1nc2c(F)ccc(Cl)c2c(=O)n1-c1ccc(N)nc1)C1CC1 CHEMBL3908617 IC50 3.0 nM
O=C(c1cc(C2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1)N1CCC(O)CC1 CHEMBL4083021 IC50 3.0 nM
C[C@@H](Nc1cccc(F)c1)c1cc(C(=O)NCCO)cc2ncc(N3CCOCC3)nc12 CHEMBL4127822 Kd 3.0 nM
O=S(=O)(Nc1cc(-c2cnc3[nH]cc(-c4ccncc4)c3c2)cnc1Cl)c1ccccc1F CHEMBL4213317 IC50 3.0 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(-c4ccc(N5CCOCC5)cc4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4853440 IC50 3.04 nM
COc1c(OC[C@H](O)CN2CCOCC2)ccc2c1N=C(NC(=O)c1cccnc1C)N1CCN=C21 CHEMBL3644672 IC50 3.09 nM
COc1c(OC[C@H](O)CN2CCCC2)ccc2c1N=C(NC(=O)c1cnco1)N1CCN=C21 CHEMBL3644670 IC50 3.09 nM
CN(C)C(=O)c1cc(C2CCCN2c2ccccc2)c2oc(N3CCOCC3)cc(=O)c2c1 CHEMBL4086125 IC50 3.2 nM
NC(=O)[C@H]1CCCN1C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL5091789 IC50 3.2 nM
C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2c(Cl)cc(F)cc2c(=O)n1-c1cc[nH]n1 CHEMBL4082978 EC50 3.4 nM
CN(C)C(=O)c1cc([C@H]2CCCN2c2ccc(F)cc2)c2oc(N3CCOCC3)cc(=O)c2c1 CHEMBL4102511 IC50 3.4 nM
COc1ncc(-c2cc3c(C)nc(NC(C)=O)nc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4228946 IC50 3.4 nM
COc1c(OC[C@H](O)CN2CCCC2)ccc2c1N=C(NC(=O)c1cncs1)N1CCN=C21 CHEMBL3644668 IC50 3.41 nM
CC(=O)Nc1cn2nc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)ccc2n1 CHEMBL1822054 Ki 3.5 nM
Nc1ncc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)c(C(F)(F)F)n1 CHEMBL4102855 Kd 3.5 nM
CN(C)C1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)nc(N5CCOCC5)n4)cc3)cc2)CC1 CHEMBL592445 Kd 3.5 nM
O=S(=O)(Nc1cc(-c2cc3c(-c4ccncc4)ncnc3s2)cnc1Cl)c1ccc(F)cc1F CHEMBL3577925 IC50 3.6 nM
N#Cc1c(N)nc(N)nc1N[C@H](c1nc2c(Cl)ccc(Cl)c2c(=O)n1-c1cnc(N)cn1)C1CC1 CHEMBL3928265 IC50 3.6 nM
COc1c(OC[C@H](O)CN2CC3CCC(C2)O3)ccc2c1N=C(NC(=O)c1cccnc1)N1CCN=C21 CHEMBL3644652 IC50 3.68 nM
COc1c(OCCCN2CCOCC2)ccc2c1N=C(NC(=O)c1cnc(N)nc1)N1CCN=C21 CHEMBL3218576 IC50 3.7 nM
N#Cc1c(N)nc(N)nc1N[C@H](c1nc2c(Cl)cc(F)cc2c(=O)n1-c1cc[nH]n1)C1CC1 CHEMBL4081433 EC50 3.7 nM
Cc1c(CN2CCN(C(=O)[C@H](C)O)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1922094 Kd 3.8 nM
CC(C)n1c(-c2nc3c(s2)CCOc2cc(-c4cnn(CC(C)(C)O)c4)ccc2-3)n[nH]c1=O CHEMBL2381381 IC50 3.9 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CCNC3)ccc1-2 CHEMBL2381266 IC50 3.9 nM
COc1c(OC[C@H](O)CN2CCCC2)ccc2c1N=C(NC(=O)c1cccnc1C)N1CCN=C21 CHEMBL3644666 IC50 3.9 nM
COc1c(OC[C@H](O)CN2CCC2)ccc2c1N=C(NC(=O)c1cccnc1C)N1CCN=C21 CHEMBL3644653 IC50 3.94 nM
Cc1nn2c(O)cc(C3CCOCC3)nc2c1Cc1cccc(C(F)(F)F)c1C CHEMBL2322333 pIC50 3.981 nM
O=c1cc(N2CCOCC2)nc2n(Cc3cccc4ccccc34)c3ccccc3n12 CHEMBL1957862 IC50 4.0 nM
Cc1ncnc(-n2c(Nc3cccc(O)c3)nc3ccccc32)n1 CHEMBL2165051 Ki 4.0 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CN(C[C@H](O)CO)C3)ccc1-2 CHEMBL2381275 IC50 4.0 nM
CC1Cc2ccccc2N1C(=O)Cc1nc(N2CCOCC2)cc(=O)[nH]1 CHEMBL3112862 IC50 4.0 nM
O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)N1CCc2cc(F)ccc21 CHEMBL3112847 IC50 4.0 nM
O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)N1CCc2ccccc21 CHEMBL3112690 IC50 4.0 nM
CC(Nc1cccc(Cl)c1F)c1cc(C(=O)NCCN(C)C)cn2c(=O)cc(N3CCOCC3)nc12 CHEMBL3319485 IC50 4.0 nM
C[C@@H]1CN(c2cc(=O)c3cc(C(=O)N4CCOCC4)cc(CN4CCOc5c(F)cccc54)c3o2)CCO1 CHEMBL3799158 IC50 4.0 nM
CC(Nc1ccc(F)c(Cl)c1)c1cc(C(=O)N(C)CCO)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656392 IC50 4.0 nM
CC(Nc1cccc(Cl)c1)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3408245 IC50 4.0 nM
CC(Nc1cccc(F)c1F)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3408246 IC50 4.0 nM
Cc1ccc(F)cc1NC(C)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656410 IC50 4.0 nM
CC(Nc1cc(F)ccc1Cl)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656414 IC50 4.0 nM
Cc1ccc(Cl)cc1NC(C)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656416 IC50 4.0 nM
COc1cc(F)cc(NC(C)c2cc(C(=O)N(C)C)cc3c(=O)cc(N4CCOCC4)oc23)c1 CHEMBL3408254 IC50 4.0 nM
C#Cc1cc(F)cc(NC(C)c2cc(C(=O)N(C)C)cc3c(=O)cc(N4CCOCC4)oc23)c1 CHEMBL3656420 IC50 4.0 nM
CCN(CC)C(=O)c1cc(C(C)Nc2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1 CHEMBL3408261 IC50 4.0 nM
CC(Nc1cc(F)cc(F)c1)c1cc(C(=O)N2CCN(C)CC2)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656428 IC50 4.0 nM
CC(Nc1cc(F)cc(F)c1)c1cc(C(=O)N2CCNCC2)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656429 IC50 4.0 nM
CC(Nc1cc(F)cc(F)c1)c1cc(C(=O)N2CCCCCC2)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656431 IC50 4.0 nM
CC(Nc1cc(F)cc(F)c1)c1cc(C(=O)N(C)CCO)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3408260 IC50 4.0 nM
CC(Nc1cc(F)cc(F)c1)c1cc(C(=O)N2CC(O)C2)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656433 IC50 4.0 nM
CC(Nc1cc(F)cc(F)c1)c1cc(C(=O)NCCO)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656435 IC50 4.0 nM
COCCNC(=O)c1cc(C(C)Nc2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1 CHEMBL3408269 IC50 4.0 nM
CC(Nc1cc(F)cc(F)c1)c1cc(C(=O)NCCF)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656437 IC50 4.0 nM
CC(Nc1cc(F)cc(F)c1)c1cc(C(=O)N2CCC[C@H]2CO)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656440 IC50 4.0 nM
CNC(=O)c1cc(C(C)Nc2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1 CHEMBL3639553 IC50 4.0 nM
COCCN(C)C(=O)c1cc(C(C)Nc2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1 CHEMBL3408259 IC50 4.0 nM
COC1CCN(C(=O)c2cc(C(C)Nc3cc(F)cc(F)c3)c3oc(N4CCOCC4)cc(=O)c3c2)CC1 CHEMBL3656443 IC50 4.0 nM
CC(Nc1cc(F)cc(F)c1)c1cc(C(=O)N2CCC2)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656432 IC50 4.0 nM
CC(Nc1cc(F)cc(F)c1)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCO[C@H](C)C3)oc12 CHEMBL3656448 IC50 4.0 nM
O=S(=O)(Nc1cc(-c2cnc3[nH]nc(-c4ccncc4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4212775 IC50 4.0 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C(C)(C)C(N)=O)c4)cc2OCC3)n(C(C)C)n1 CHEMBL2387080 IC50 4.0 nM
COc1c(OC[C@H](O)CN(C(C)C)C(C)C)ccc2c1N=C(NC(=O)c1cccnc1C)N1CCN=C21 CHEMBL3644661 IC50 4.2 nM
N#Cc1c(N)nc(N)nc1N[C@H](c1nc2cccc(Cl)c2c(=O)n1-c1cnc(N)cn1)C1CC1 CHEMBL3912814 IC50 4.2 nM
C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2cccc(Cl)c2c(=O)n1-c1cc[nH]n1 CHEMBL4074361 EC50 4.2 nM
NC(=O)[C@@H]1CCCN1C(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1 CHEMBL5071942 IC50 4.3 nM
Cc1nc(N)nc(-c2cccnc2Nc2cnc(Cl)c(NS(C)(=O)=O)c2)n1 CHEMBL2206913 Ki 4.4 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(F)ccc(Cl)c2c(=O)n1-c1cnc(N)cn1 CHEMBL3915208 IC50 4.4 nM
O=C(c1cc(C2CCCN2c2ccc(F)cc2)c2oc(N3CCOCC3)cc(=O)c2c1)N1CCOCC1 CHEMBL4062879 IC50 4.5 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CN(CCO)C3)ccc1-2 CHEMBL2381274 IC50 4.6 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(N4CCCCC4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4876806 IC50 4.6 nM
COc1cnc(Nc2cnc(Cl)c(NS(=O)(=O)N(C)C)c2)c(-c2nc(C)nc(N)n2)c1 CHEMBL2206904 Ki 4.7 nM
COc1c(OC[C@H](O)CN2CC3CCC(C2)O3)ccc2c1N=C(NC(=O)c1cnc(N)nc1)N1CCN=C21 CHEMBL3644655 IC50 4.71 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(-c4cnc(N5CCOCC5)nc4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4871838 IC50 4.72 nM
COc1c(OC[C@H](O)CN(C(C)C)C(C)C)ccc2c1N=C(NC(=O)c1cccnc1)N1CCN=C21 CHEMBL3644660 IC50 4.74 nM
O=S(=O)(Nc1cc(-c2ccc3ncc(N4CCNCC4)nc3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL5220248 IC50 4.77 nM
FC(F)c1nc2ccccc2n1-c1nc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL586702 IC50 4.8 nM
COc1c(OC[C@H](O)CN2C[C@@H](C)O[C@@H](C)C2)ccc2c1N=C(NC(=O)c1cccnc1)N1CCN=C21 CHEMBL3644651 IC50 4.85 nM
Cc1c(Cl)cccc1Cn1c(S)nc(=O)c2sc(N3CCOCC3)nc21 CHEMBL2089117 IC50 5.0 nM
O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)Nc1cccc(Br)c1 CHEMBL2151923 IC50 5.0 nM
COc1ccc(Nc2ncc(CN3CCC(S(C)(=O)=O)C3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165004 Ki 5.0 nM
COc1ccc(Nc2ncc(CN3CCC(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165019 Ki 5.0 nM
COc1ccc(Nc2ncc(CN3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165017 Ki 5.0 nM
O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)N1CCc2c(F)cccc21 CHEMBL3112848 IC50 5.0 nM
C[C@@H](Nc1cccc(Cl)c1F)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3408250 IC50 5.0 nM
C[C@@H](Nc1cc(F)c(F)c(F)c1)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3408256 IC50 5.0 nM
COCCN(Cc1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCO[C@H](C)C3)oc12)c1cc(F)cc(F)c1 CHEMBL3800231 IC50 5.0 nM
CC(Nc1cccc(Cl)c1F)c1cc(C(=O)N(C)CCO)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656393 IC50 5.0 nM
CC(Nc1cc(F)cc(F)c1)c1cc(C(=O)N2CCOCC2)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3408265 IC50 5.0 nM
CC(Nc1cccc(F)c1)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3407508 IC50 5.0 nM
Cc1cc(F)cc(NC(C)c2cc(C(=O)N(C)C)cc3c(=O)cc(N4CCOCC4)oc23)c1 CHEMBL3408253 IC50 5.0 nM
CC(Nc1cccc(Cl)c1Cl)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656407 IC50 5.0 nM
C#Cc1cccc(NC(C)c2cc(C(=O)N(C)C)cc3c(=O)cc(N4CCOCC4)oc23)c1 CHEMBL3656408 IC50 5.0 nM
Cc1c(C#N)cccc1NC(C)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656417 IC50 5.0 nM
CC(Nc1cc(Cl)cc(Cl)c1)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3408255 IC50 5.0 nM
CC(Nc1cc(F)cc(F)c1)c1cc(C(=O)N2CCCCC2)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3408264 IC50 5.0 nM
CCNC(=O)c1cc(C(C)Nc2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1 CHEMBL3408268 IC50 5.0 nM
CC(Nc1cc(F)cc(F)c1)c1cc(C(=O)N2CCC[C@@H]2CO)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656439 IC50 5.0 nM
CC(Nc1cc(F)cc(F)c1)c1cc(C(=O)N2CCCOCC2)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656442 IC50 5.0 nM
CC(c1cc(C(=O)N2CCCC2)cc2c(=O)cc(N3CCOCC3)oc12)N(C)c1cc(F)cc(F)c1 CHEMBL3408276 IC50 5.0 nM
CC(c1cc(C(=O)N(C)CCO)cc2c(=O)cc(N3CCOCC3)oc12)N(C)c1cc(F)cc(F)c1 CHEMBL3895589 IC50 5.0 nM
CC(Nc1cc(F)cc(C#N)c1)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656405 IC50 5.0 nM
CC(Nc1ccc(F)cc1)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCO[C@H](C)C3)oc12 CHEMBL3656447 IC50 5.0 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(Cl)cc(F)cc2c(=O)n1-c1ccc(N)nc1 CHEMBL3957788 IC50 5.0 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCN(C(C)=O)C4)c3c2)cc1NS(C)(=O)=O CHEMBL4449091 IC50 5.0 nM
Cc1nc2c(-c3nnc[nH]3)cc(-c3ccnc(C#N)c3)cc2n1-c1ccnc2c(F)ccc(F)c12 CHEMBL4647791 EC50 5.0 nM
Cc1nn2c(C(=O)O)cc(N3CCOCC3)nc2c1Cc1cccc(C(F)(F)F)c1C CHEMBL2322349 pIC50 5.012 nM
Cc1c(Cc2cnn3c(O)cc(N4CCOCC4)nc23)cccc1C(F)(F)F CHEMBL2322336 pIC50 5.012 nM
Cc1nc2c(C(=O)O)cc(N3CCOCC3)nc2n1Cc1cccc(Cl)c1Cl CHEMBL2431397 pIC50 5.012 nM
Cc1c(Cn2c(C)nc3c(C(=O)O)cc(N4CCOCC4)nc32)cccc1C(F)(F)F CHEMBL2431398 pIC50 5.012 nM
C[C@@H](NC(=O)c1ccc(NC(=O)Nc2ccc(-c3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2)cc1)C(N)=O CHEMBL5093540 IC50 5.1 nM
COc1ncc(-c2nc3c(N4CCOCC4)ncnc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4798343 IC50 5.3 nM
COc1c(OC[C@H](O)CN2CCOCC2)ccc2c1N=C(NC(=O)c1sc(N)nc1C)N1CCN=C21 CHEMBL3644679 IC50 5.32 nM
CC1CCN(c2cnnc3ccc(-c4cnc(Cl)c(NS(=O)(=O)c5ccccc5)c4)cc23)CC1 CHEMBL4878126 IC50 5.33 nM
COc1c(OC[C@H](O)CN2C[C@@H](C)O[C@@H](C)C2)ccc2c1N=C(NC(=O)c1cccnc1C)N1CCN=C21 CHEMBL3644654 IC50 5.36 nM
CC(=O)N1CCN(c2cnc3ccc(-c4cnc(Cl)c(NS(=O)(=O)c5ccc(F)cc5)c4)cc3n2)CC1 CHEMBL5220911 IC50 5.36 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CCCN3)ccc1-2 CHEMBL2381267 IC50 5.4 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(N4CCCC4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4845684 IC50 5.41 nM
COc1c(OCC(O)CN(C)C)ccc2c1N=C(NC(=O)c1cccnc1)N1CCN=C21 CHEMBL3644659 IC50 5.47 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1ccccc1-2 CHEMBL2381253 IC50 5.5 nM
COc1c(OC[C@H](O)CN2C[C@@H](C)O[C@@H](C)C2)ccc2c1N=C(NC(=O)c1cnc(N)nc1)N1CCN=C21 CHEMBL3644649 IC50 5.52 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCN(C(=O)C5CCOCC5)C4)c3c2)cc1NS(C)(=O)=O CHEMBL4542688 IC50 5.6 nM
CCOc1cnnc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccccc4)c3)cc12 CHEMBL4860613 IC50 5.61 nM
COc1c(OC[C@H](O)CN2CCCC2)ccc2c1N=C(NC(=O)c1scnc1C)N1CCN=C21 CHEMBL3644669 IC50 5.64 nM
CO/C=C/C(=O)c1cc2c3c(c(N)cc(NC(=O)C(C)C)c3n1)N=C2 CHEMBL4293970 Kd 5.7 nM
COc1c(OC[C@H](O)CN(C(C)C)C(C)C)ccc2c1N=C(NC(=O)c1cncs1)N1CCN=C21 CHEMBL3644663 IC50 5.83 nM
COc1c(OC[C@H](O)CN2CCOCC2)ccc2c1N=C(NC(=O)c1cncs1)N1CCN=C21 CHEMBL3644677 IC50 5.91 nM
Cc1c(Cn2c(C)c(C)n3c(=O)cc(N4CCOCC4)nc23)cccc1C(F)(F)F CHEMBL1957861 IC50 6.0 nM
Cc1c(Cn2ccn3c(=O)cc(N4CCOC(C)C4)nc23)cccc1C(F)(F)F CHEMBL1957868 IC50 6.0 nM
Cc1cc([C@@H](C)Nc2ccccc2)c2nc(N3CCOCC3)cc(=O)n2c1 CHEMBL1957875 IC50 6.0 nM
O=c1cc(N2CCOCC2)nc(Cc2nc3c(-c4ccccc4)c(F)ccc3o2)[nH]1 CHEMBL2064417 IC50 6.0 nM
Cc1cc(NC(=O)Cc2nc(N3CCOCC3)cc(=O)[nH]2)ccc1F CHEMBL2151925 IC50 6.0 nM
COc1ccc(Nc2ncc(-c3cnn(C)c3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165033 Ki 6.0 nM
C[C@@H]1Cc2ccccc2N1C(=O)Cc1nc(N2CCOCC2)cc(=O)[nH]1 CHEMBL3112867 IC50 6.0 nM
C[C@H](c1cc(C(=O)N(C)CCO)cc2c(=O)cc(N3CCOCC3)oc12)N(C)c1cc(F)cc(F)c1 CHEMBL3408277 IC50 6.0 nM
C[C@@H](Nc1cc(F)cc(F)c1F)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3408257 IC50 6.0 nM
CN(C)C(=O)c1cc(CN2CCOc3c(F)cc(F)cc32)c2oc(N3CCOCC3)cc(=O)c2c1 CHEMBL3797750 IC50 6.0 nM
C[C@@H]1CN(c2cc(=O)c3cc(C(=O)N4CCOCC4)cc(CN4CCOc5c(F)cc(F)cc54)c3o2)CCO1 CHEMBL3799673 IC50 6.0 nM
Cc1nc2c(-c3cnc[nH]3)cc(N3CCOCC3)nn2c1Cc1cccc(C(F)(F)F)c1C CHEMBL3986383 Kd 6.0 nM
Cc1nc2c(N)cc(N3CCOCC3)nn2c1Cc1cccc(C(F)(F)F)c1C CHEMBL3975628 Kd 6.0 nM
CC(Nc1ccc(F)c(Cl)c1)c1cc(C(=O)N2CCC(O)CC2)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656391 IC50 6.0 nM
CC(Nc1cccc(Cl)c1F)c1cc(C(=O)N2CCC(O)CC2)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656394 IC50 6.0 nM
CC(c1ccc(F)c(F)c1)C(C)c1cc(C(=O)NCCN(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656396 IC50 6.0 nM
CC(Nc1ccc(F)c(Cl)c1)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3408251 IC50 6.0 nM
CC(Nc1cc(F)cc(F)c1)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656399 IC50 6.0 nM
CC(Nc1cc(F)cc(F)c1F)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656403 IC50 6.0 nM
COc1ccc(F)cc1NC(C)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656412 IC50 6.0 nM
COc1c(F)cccc1NC(C)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656418 IC50 6.0 nM
O=S(=O)(Nc1cc(-c2cnc3[nH]nc(-c4ccccc4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4216255 IC50 6.0 nM
Cn1c(=O)n(-c2ccc(C(C)(C)C#N)cc2)c2c3cc(-c4cnc5ccccc5c4)ccc3ncc21 CHEMBL1879463 IC50 6.0 nM
Cc1nc2c(-c3nnc[nH]3)cc(-c3ccnc(N)c3F)cc2n1-c1ccnc2c(F)ccc(F)c12 CHEMBL4470860 EC50 6.0 nM
Cc1nc(N)ncc1-c1nc(N2CCOCC2)c2sc(CN3CCN(S(C)(=O)=O)CC3)cc2n1 CHEMBL1085177 IC50 6.2 nM
COc1c(OC[C@@H](O)CN2CCOCC2)ccc2c1N=C(NC(=O)c1cccnc1)N1CCN=C21 CHEMBL3644650 IC50 6.2 nM
COc1c(OC[C@H](O)CN2CCC2)ccc2c1N=C(NC(=O)c1cncs1)N1CCN=C21 CHEMBL3644657 IC50 6.3 nM
Oc1cc(C2CCOCC2)nc2c(Cc3cccc(Cl)c3Cl)c(C(F)(F)F)nn12 CHEMBL2322342 pIC50 6.31 nM
CC(Cc1ccc(Cl)c(Cl)c1)n1c(=O)[nH]c2c(C(N)=O)nc(-c3cccc(O)c3)nc21 CHEMBL5410207 pKi 6.31 nM
CCC(=O)Nc1nc(C)c(-c2cnc(Cl)c(NS(=O)(=O)c3ccccc3)c2)s1 CHEMBL4166220 IC50 6.6 nM
COc1ccc2c(nc(C(F)F)n2-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)c1O CHEMBL1911114 IC50 6.7 nM
COc1c(OC[C@H](O)CN(C)C)ccc2c1N=C(NC(=O)c1cnc(N)nc1)N1CCN=C21 CHEMBL3644662 IC50 6.75 nM
CCn1nnc2c(N3CCOCC3)nc(-c3ccc(NC(=O)Nc4ccc(C(=O)N5CCN(C)CC5)cc4)cc3)nc21 CHEMBL589258 IC50 7.0 nM
CN1CCN(Cc2cc3c(N4CCOCC4)nc(-c4cnc(N)nc4)nc3s2)CC1 CHEMBL1949913 Ki(app) 7.0 nM
COc1ccc(Nc2ncc(CN3CCN(S(=O)(=O)N(C)C)CC3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165018 Ki 7.0 nM
COc1ccc(Nc2ncc(CN3CCOCC3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165010 Ki 7.0 nM
COc1ccc(Nc2ncc(N3CCN(C)CC3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165031 Ki 7.0 nM
Cc1cc(-c2cc(=O)[nH]c(NCc3cccc4ccccc34)n2)ccn1 CHEMBL2165175 IC50 7.0 nM
Cc1nc(-c2nc3c(s2)CCOc2cc(-c4cnn(CCO)c4)ccc2-3)n(C(C)C)n1 CHEMBL2381378 IC50 7.0 nM
CC(Nc1ccccc1Cl)c1cc(C(=O)NCCN(C)C)cn2c(=O)cc(N3CCOCC3)nc12 CHEMBL3319644 IC50 7.0 nM
CC(Nc1ccc(F)c(F)c1)c1cc(C(=O)N(C)C)cn2c(=O)cc(N3CCOCC3)nc12 CHEMBL3319489 IC50 7.0 nM
C[C@@H](Nc1ccc(F)c(F)c1)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3408247 IC50 7.0 nM
CN(C)C(=O)c1cc(CN(C)c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1 CHEMBL3408273 IC50 7.0 nM
C[C@H](c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12)N(C)c1cc(F)cc(F)c1 CHEMBL3408274 IC50 7.0 nM
C[C@H](c1cc(C(=O)N2CCC(O)CC2)cc2c(=O)cc(N3CCOCC3)oc12)N(C)c1cc(F)cc(F)c1 CHEMBL3408278 IC50 7.0 nM
CC(=O)Nc1cn2cc(-c3cnc(N)c(OC(C)C(F)(F)F)n3)ccc2n1 CHEMBL3753450 IC50 7.0 nM
CC(Nc1ccc(F)cc1)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3408244 IC50 7.0 nM
CC(Nc1ccc(F)cc1)c1cc(C(=O)N(C)CCN(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656390 IC50 7.0 nM
CC(Nc1cc(F)cc(F)c1)c1cc(C(=O)N2CC[C@H](O)C2)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656395 IC50 7.0 nM
CC(c1cc(C(=O)N2CCC(O)C2)cc2c(=O)cc(N3CCOCC3)oc12)N(C)c1cc(F)cc(F)c1 CHEMBL3656445 IC50 7.0 nM
CC(c1cc(C(=O)N2CCC[C@@H]2CO)cc2c(=O)cc(N3CCOCC3)oc12)N(C)c1cc(F)cc(F)c1 CHEMBL3656446 IC50 7.0 nM
CC(c1ccc(F)cc1)C(C)c1cc(C(=O)NCCN(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656455 IC50 7.0 nM
COc1c(OC[C@H](O)CN2C[C@@H](C)O[C@@H](C)C2)ccc2c1N=C(NC(=O)c1cncs1)N1CCN=C21 CHEMBL3644656 IC50 7.21 nM
COc1c(OC[C@H](O)CN2CCOCC2)ccc2c1N=C(NC(=O)c1ccc(N)nc1C)N1CCN=C21 CHEMBL3644674 IC50 7.3 nM
Cc1nc(NC(=O)[C@@H](N)C(C)C)sc1-c1cnc(Cl)c(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1 CHEMBL4175347 IC50 7.3 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3cnn(C(C)(C)C(N)=O)c3)ccc1-2 CHEMBL2381377 IC50 7.4 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CN(C(=O)CO)C3)ccc1-2 CHEMBL2381277 IC50 7.6 nM
Nc1nc(N)c(Cl)c(N[C@H](c2nc3cccc(Cl)c3c(=O)n2-c2cc[nH]n2)C2CC2)n1 CHEMBL4101102 EC50 7.6 nM
COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C(C3=O)[C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O CHEMBL428496 Kd 7.6 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3cn[nH]c3)ccc1-2 CHEMBL2381269 IC50 7.9 nM
Nc1nn2c(O)cc(C3CCOCC3)nc2c1Cc1cccc(Cl)c1Cl CHEMBL2322345 pIC50 7.943 nM
O=c1cc(N2CCOCC2)nc2n(Cc3cccc(Cl)c3Cl)c3ccccc3n12 CHEMBL1957859 IC50 8.0 nM
O=c1cc(N2CCOCC2)nc(Cc2nc3ccccc3n2-c2ccccc2)[nH]1 CHEMBL2064344 IC50 8.0 nM
Cc1c(Cl)cccc1Cn1c(=O)[nH]c(=O)c2sc(N3CCOCC3)nc21 CHEMBL2089115 IC50 8.0 nM
O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)N1CCc2c(-c3ccccc3)cccc21 CHEMBL3112855 IC50 8.0 nM
CC1Cc2c(Cl)cccc2N1C(=O)Cc1nc(N2CCOCC2)sc1C(=O)O CHEMBL3125379 IC50 8.0 nM
CC(Nc1ccccc1)c1cc(C(=O)NCCN(C)C)cn2c(=O)cc(N3CCOCC3)nc12 CHEMBL3318715 IC50 8.0 nM
CC(Nc1cc(F)cc(F)c1)c1cc(C(=O)N(C)CCO)cn2c(=O)cc(N3CCOCC3)nc12 CHEMBL3319494 IC50 8.0 nM
CN(C)C(=O)c1cc(CNc2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1 CHEMBL3408272 IC50 8.0 nM
CN(C)C(=O)c1cc(CN2CCOc3c(F)cccc32)c2oc(N3CCOCC3)cc(=O)c2c1 CHEMBL3799831 IC50 8.0 nM
CC(Nc1c(F)ccc(Cl)c1F)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656419 IC50 8.0 nM
CC(Nc1cc(F)cc(F)c1)c1cc(C(=O)N2CCSCC2)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656430 IC50 8.0 nM
CC(c1cc(C(=O)N2CCC(O)CC2)cc2c(=O)cc(N3CCOCC3)oc12)N(C)c1cc(F)cc(F)c1 CHEMBL3656444 IC50 8.0 nM
COc1c(-c2ccccc2)c([C@H](C)Nc2ncnc(N)c2C#N)nc2ccc(F)cc12 CHEMBL3403665 IC50 8.2 nM
COc1c(OCC(O)CN2CCOCC2)ccc2c1N=C(NC(=O)c1cnc(N)nc1)N1CCN=C21 CHEMBL3644675 IC50 8.3 nM
C[C@H]1OC(=O)N(c2nc(-c3cnc(N)nc3C(F)(F)F)cc(N3CCOCC3)n2)[C@H]1CO CHEMBL5203121 IC50 8.3 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CCNCC3)ccc1-2 CHEMBL2381268 IC50 8.4 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CN(CC(C)(C)O)C3)ccc1-2 CHEMBL2381276 IC50 8.5 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3cnn(CCO)c3)ccc1-2 CHEMBL2381373 IC50 8.6 nM
COc1c(OC[C@H](O)CN2CCOCC2)ccc2c1N=C(NC(=O)c1cnc3[nH]cnc3c1)N1CCN=C21 CHEMBL3644676 IC50 8.83 nM
CN1CCN(c2nc3ccccc3cc2Cn2nc(-c3ccc4nc(N)sc4c3)c3c(N)ncnc32)CC1 CHEMBL1213118 IC50 9.0 nM
Cc1nc(N)nc(-n2c(Nc3cccc(O)c3)nc3ccccc32)n1 CHEMBL1762788 IC50 9.0 nM
O=c1cc(N2CCOCC2)nc(Cc2nc3cc(F)ccc3n2C2CC2)[nH]1 CHEMBL2064341 IC50 9.0 nM
COc1ccc(Nc2ncc(N3CCOCC3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165029 Ki 9.0 nM
Cc1nc(N)nc(-c2cccnc2Nc2cccc3[nH]ccc23)n1 CHEMBL2165268 Ki 9.0 nM
O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)N1CCc2c1cccc2C(F)(F)F CHEMBL3112853 IC50 9.0 nM
Cc1cc(C(C)Nc2cc(F)cc(F)c2)c2nc(N3CCOCC3)cc(=O)n2c1 CHEMBL3319642 IC50 9.0 nM
C[C@H](Nc1cc(F)cc(F)c1)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCO[C@@H](C)C3)oc12 CHEMBL3408271 IC50 9.0 nM
CN(C)C(=O)c1cc(CN2CCOc3ccc(F)cc32)c2oc(N3CCOCC3)cc(=O)c2c1 CHEMBL3799187 IC50 9.0 nM
CC(Nc1cccc(Cl)c1F)c1cc(C(=O)NCCN(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656389 IC50 9.0 nM
CC(Nc1ccc(F)c(F)c1)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3916146 IC50 9.0 nM
CC(Nc1c(F)ccc(F)c1F)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656415 IC50 9.0 nM
CC(Nc1cc(F)cc(F)c1)c1cc(C(=O)N2CC(F)C2)cc2c(=O)cc(N3CCOCC3)oc12 CHEMBL3656434 IC50 9.0 nM
CCCNC(=O)c1cc(C(C)Nc2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1 CHEMBL3656436 IC50 9.0 nM
CC(c1cc(C(=O)N2CCC(O)CC2)cc2c(=O)cc(N3CCO[C@H](C)C3)oc12)N(C)c1cc(F)cc(F)c1 CHEMBL3656453 IC50 9.0 nM
C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2cccc(Cl)c2c(=O)n1-c1ccc(N)nc1 CHEMBL3970845 IC50 9.0 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCCN(C(=O)c5cccnc5)C4)c3c2)cc1C#N CHEMBL4468088 IC50 9.1 nM
CC(C)n1nc(N)nc1-c1nc2c(s1)CCOc1cc(-c3cnn(CC(C)(C)O)c3)ccc1-2 CHEMBL2381380 IC50 9.2 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3cn(C)cn3)ccc1-2 CHEMBL2381271 IC50 9.3 nM
COc1c(OCC(O)CN2CCOCC2)ccc2c1N=C(NC(=O)c1ccc(N)nc1)N1CCN=C21 CHEMBL3644647 IC50 9.37 nM
COc1ncc(-c2ccc3nccc(C#CCN4CCN(S(C)(=O)=O)CC4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3763244 IC50 9.4 nM
CC(C)N1CCN(c2cnc3ccc(-c4cnc(Cl)c(NS(=O)(=O)c5ccc(F)cc5)c4)cc3n2)CC1 CHEMBL1914742 IC50 9.6 nM
O=S(=O)(Nc1cc(-c2ccc3ncc(NCCN4CCOCC4)nc3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914736 IC50 9.8 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(F)cc(F)cc2c(=O)n1-c1cnc(N)cn1 CHEMBL3906405 IC50 9.8 nM
COc1c(OCC(O)CN2CCOCC2)ccc2c1N=C(NC(=O)c1cccnc1)N1CCN=C21 CHEMBL3644646 IC50 9.92 nM
COc1c(OCC(O)CN2CCSCC2)ccc2c1N=C(NC(=O)c1cccnc1)N1CCN=C21 CHEMBL3644658 IC50 9.96 nM