C[C@H](Nc1ncnc2[nH]cnc12)C1=Nc2cccc(Cl)c2S(=O)(=O)N1c1ccccc1 CHEMBL4468379 IC50 0.0 nM
COc1ncc(-c2ccc3nccc(-c4ccnnc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL1236962 Ki 0.02 nM
Cc1cccc2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cccc(NS(C)(=O)=O)c5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL4441003 IC50 0.04 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C)c4N4CCN(C)[C@H](C(C)C)C4)cc2OCC3)n(C(C)C)n1 CHEMBL3704739 IC50 0.048 nM
COc1ncc(-c2cc(-c3ncc(CN4C[C@@H](C)O[C@@H](C)C4)o3)c3cn[nH]c3c2)cc1NS(C)(=O)=O CHEMBL4434674 pKi 0.07943 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2c(S(C)(=O)=O)c1-c1ccccc1 CHEMBL3403664 IC50 0.1 nM
CC(Nc1ncnc2[nH]cnc12)c1cc2ccccn2c(=O)c1-c1ccccc1 CHEMBL4541570 IC50 0.1 nM
Cc1nc(-c2cn3c(n2)-c2cnc(N4CCCC4C4CCCCN4C)cc2OCC3)n(CC(F)(F)F)n1 CHEMBL3704656 IC50 0.102 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C(C)(C)C(N)=O)c4)cc2OCC3)n(C(C)C)n1 CHEMBL2387080 Ki 0.12 nM
Cc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)[C@H](C)O)CC2)c(=O)n4C)cn1 CHEMBL2331664 Ki 0.122 nM
CC(C)N1CCN(Cc2cnc(-c3cc(-c4cccc5[nH]ccc45)cc4[nH]ncc34)o2)CC1 CHEMBL2216859 pKi 0.1259 nM
Cc1nc(-c2cn3c(n2)-c2ccc(N4CCC4[C@@H]4CCCN(C(C)C)C4)cc2OCC3)n(C(C)C)n1 CHEMBL3704723 IC50 0.16 nM
Cc1nc(-c2cn3c(n2)-c2ccc(N4CCCC45CCCN(C)C5)cc2OCC3)n(C(C)C)n1 CHEMBL3704706 IC50 0.178 nM
COc1ncc(-c2cc(OC3CCOCC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4166144 IC50 0.18 nM
COc1c(OCCCN2CCOCC2)ccc2c1N=C(NC(=O)c1cnc(N)nc1)N1CCN=C21 CHEMBL3218576 IC50 0.18 nM
COCCS(=O)(=O)Nc1cc(-c2cc3c(c(OC[C@H]4CN(C5COC5)CCO4)c2)COC3)cnc1OC CHEMBL4579923 pKd(app) 0.1995 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2n1-c1ccccc1 CHEMBL2216895 Ki 0.2 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2c(NCCS(C)(=O)=O)c1-c1ccccc1 CHEMBL2216892 IC50 0.2 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cnc6[nH]ccc6c5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3969288 IC50 0.2 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cnn(CCCO)c5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3985740 IC50 0.2 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5ccn(CC(F)(F)F)n5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3947405 IC50 0.2 nM
COc1ncc(-c2c(N)ncnc2N[C@@H](C)c2nn3ccc(C)c3c(=O)n2-c2ccccc2)cc1NS(=O)(=O)c1ccc(O)cc1 CHEMBL3929491 IC50 0.2 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5ccn(-c6cccc(O)c6)n5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3979599 IC50 0.2 nM
Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3C(=O)Oc3cc(O)cc(NS(C)(=O)=O)c3)n(-c3ccccc3)c(=O)c12 CHEMBL3967455 IC50 0.2 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cc(NS(C)(=O)=O)c6cc[nH]c6c5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3895194 IC50 0.2 nM
C[C@H](Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2cc1-c1ccccc1 CHEMBL4470131 IC50 0.2 nM
C[C@H](Nc1ncnc(N)c1-c1nnn[nH]1)c1nn2cccc2c(=O)n1-c1ccccc1 CHEMBL3982040 IC50 0.2 nM
CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(CCCCCC(=O)NO)c2c(=O)n1-c1ccccc1 CHEMBL4451623 IC50 0.2 nM
CC[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(CCCCCC(=O)NO)c2c(=O)n1-c1ccccc1 CHEMBL4443378 IC50 0.2 nM
CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(CCc3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1 CHEMBL4450613 IC50 0.2 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2c(C(=O)N2CCNCC2)c1-c1ccccc1 CHEMBL4449576 IC50 0.2 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(-n4ccnc4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4871213 IC50 0.21 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CC3CN(C4CCS(=O)(=O)CC4)C3)n(C)c2n1 CHEMBL2414299 Ki(app) 0.23 nM
COc1ncc(-c2cc(O[C@@H]3CCOC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4176771 IC50 0.23 nM
C[C@H](Nc1ncnc2nc[nH]c12)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1 CHEMBL3039502 IC50 0.24 nM
COc1ncc(-c2cc3c(c(OCCN4CCC(C(C)(C)O)CC4)c2)COC3)cc1NS(C)(=O)=O CHEMBL4556087 pKd(app) 0.2512 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C)c4C4CCCN(C(C)(C)CO)C4)cc2OCC3)n(C(C)C)n1 CHEMBL3704663 IC50 0.262 nM
Nc1ncnc2c1c(-c1cc(O)c(Br)c(F)c1)nn2C1CCc2ccccc2C1 CHEMBL5274907 IC50 0.27 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(-c4ccc(N5CCOCC5)nc4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4872728 IC50 0.28 nM
Cc1nc(-c2cn3c(n2)-c2ccc(N4CCCC4CN(C)C)cc2OCC3)n(C(C)C)n1 CHEMBL3704725 IC50 0.288 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4ccnn4C4CCCN(C(C)(C)CO)C4)cc2OCC3)n(C(C)C)n1 CHEMBL3704672 IC50 0.292 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C)c4C4CCCN(C(C)C)C4)cc2OCC3)n(C(C)C)n1 CHEMBL3704682 IC50 0.293 nM
Cc1ccccc1-n1c(Cn2nc(-c3cc(O)cc(F)c3)c3c(N)ncnc32)cc2cccc(C)c2c1=O CHEMBL2216876 IC50 0.3 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(C#Cc5ccccc5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3917021 IC50 0.3 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cccc(S(=O)(=O)N6CCOCC6)c5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3984467 IC50 0.3 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5ccn(CC(C)(C)CO)n5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3892452 IC50 0.3 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cc(O)cc(NC(N)=O)c5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3967037 IC50 0.3 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cc(NS(C)(=O)=O)cc(C(=O)N(C)C)c5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3980811 IC50 0.3 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4ccnn4C4CCOCC4)c4c(N)ncnn34)c2)C(=O)C1(C)C CHEMBL4068514 IC50 0.3 nM
CC[C@@H]1CN(c2cc(-c3cc(Cl)c4c(N)ncnn34)ccc2C#N)C(=O)C(C)(C)O1 CHEMBL4080090 IC50 0.3 nM
[2H]C([2H])([2H])C1([2H])N(c2cc(-c3cc(Cl)c4c(N)ncnn34)ccc2C#N)C(=O)C(C)(C)OC1([2H])[2H] CHEMBL4061320 IC50 0.3 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 CHEMBL3805430 EC50 0.3 nM
CC(c1nn(-c2cccnc2)c2cc(Cl)ccc12)n1nc(-c2ccc(O)c(F)c2)c2c(N)ncnc21 CHEMBL5395433 IC50 0.3 nM
N#Cc1c(N)nc(N)nc1N[C@H](c1nc2c(F)ccc(Cl)c2c(=O)n1-c1cccnc1)C1CC1 CHEMBL3928407 EC50 0.31 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4cn[nH]c4C4CCCN(C(C)C)C4)cc2OCC3)n(C(C)C)n1 CHEMBL3704735 IC50 0.311 nM
Cc1nc(-c2cn3c(n2)-c2ccc(N4CCC[C@H]4CN4CCCC4)cc2OCC3)n(C(C)C)n1 CHEMBL3704710 IC50 0.313 nM
Cc1nc(-c2cn3c(n2)-c2cc(-c4ccnn4C4CCCN(C(C)(C)CO)C4)c(F)cc2OCC3)n(C(C)C)n1 CHEMBL3704730 IC50 0.314 nM
CC1CCN(c2cnnc3ccc(-c4cnc(Cl)c(NS(=O)(=O)c5ccccc5)c4)cc23)CC1 CHEMBL4878126 IC50 0.32 nM
CNc1nc(C)c2cc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4F)c3)cc(OC3CCOCC3)c2n1 CHEMBL4166594 IC50 0.35 nM
COc1ncc(-c2ccc3ncc(-c4cn(CCCN5CCOCC5)nn4)n3n2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL5395998 IC50 0.35 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CC3CN(C(=O)C(C)C)C3)n(C)c2n1 CHEMBL2414301 Ki(app) 0.36 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(-c4ccncc4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4864419 IC50 0.36 nM
Cc1nc(-c2cn3c(n2)-c2cc(-c4cnn(C)c4C4CCCN(C(C)C)C4)c(F)cc2OCC3)n(C(C)C)n1 CHEMBL3704734 IC50 0.37 nM
CNc1nc(C)c2cc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4F)c3)cc(O[C@@H]3CCOC3)c2n1 CHEMBL4174909 IC50 0.37 nM
Cc1nc(N)nc(-n2c(Nc3cc(O)cc(O)c3)nc3ccccc32)n1 CHEMBL1762790 IC50 0.4 nM
Cc1nc(N)nc(-c2cc(Cl)cnc2Nc2cnc(Cl)c(NS(=O)(=O)N(C)C)c2)n1 CHEMBL2206921 Ki 0.4 nM
CC(Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2c(NCCO)c1-c1ccccc1 CHEMBL3403669 IC50 0.4 nM
Cc1cccc2nc([C@H](C)Nc3nc(N)nc(N)c3C#N)n(-c3cccnc3)c(=O)c12 CHEMBL3908006 IC50 0.4 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(F)ccc(Cl)c2c(=O)n1-c1cccnc1 CHEMBL3915848 IC50 0.4 nM
Cc1ccncc1-n1c([C@H](C)Nc2nc(N)nc(N)c2C#N)nc2cccc(Cl)c2c1=O CHEMBL3900134 IC50 0.4 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(Cc5cc(O)cc(F)c5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3908163 IC50 0.4 nM
Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3-c3cccc(NS(=O)(=O)c4ccc(O)cc4)c3)n(-c3ccccc3)c(=O)c12 CHEMBL3940714 IC50 0.4 nM
CCNc1nnc(-c2c[nH]c3ncnc(N[C@@H](C)c4nn5ccc(C)c5c(=O)n4-c4ccccc4)c23)s1 CHEMBL3949490 IC50 0.4 nM
Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3-c3cncc(OC(F)F)c3)n(-c3ccccc3)c(=O)c12 CHEMBL3912595 IC50 0.4 nM
COc1cc(C#N)cc(-c2c[nH]c3ncnc(N[C@@H](C)c4nn5ccc(C)c5c(=O)n4-c4ccccc4)c23)c1 CHEMBL3976670 IC50 0.4 nM
COc1ccc(S(=O)(=O)n2ncc3ccc(-c4c(N)ncnc4N[C@@H](C)c4nn5ccc(C)c5c(=O)n4-c4ccccc4)cc32)cc1 CHEMBL3914806 IC50 0.4 nM
Cc1nnc(-c2cccc(-c3c[nH]c4ncnc(N[C@@H](C)c5nn6ccc(C)c6c(=O)n5-c5ccccc5)c34)c2)o1 CHEMBL3972794 IC50 0.4 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5ccnc(N6CCC(N(C)C)CC6)c5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3910737 IC50 0.4 nM
CC[C@H]1COC(C)(C)C(=O)N1c1cc(-c2cc(Cl)c3c(N)ncnn23)ccc1C#N CHEMBL4060977 IC50 0.4 nM
CC[C@H]1COC(C)(C)C(=O)N1c1cc(-c2cc(C(F)(F)F)c3c(N)ncnn23)ccc1C#N CHEMBL4090297 IC50 0.4 nM
[2H]C1([2H])OC(C)(C)C(=O)N(c2cc(-c3cc(Cl)c4c(N)ncnn34)ccc2C#N)C1([2H])[2H] CHEMBL4097187 IC50 0.4 nM
CCOc1cnnc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccccc4)c3)cc12 CHEMBL4860613 IC50 0.4 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(-c4ccc(N5CCOCC5)cc4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4853440 IC50 0.4 nM
Cc1nc(-c2cn3c(n2)-c2ccc(N4CCC[C@@H]4CN4CCCC4)cc2OCC3)n(C(C)C)n1 CHEMBL3704711 IC50 0.416 nM
Cc1nc(-c2cn3c(n2)-c2ccc(N4CCC4C4CCN(C)CC4)cc2OCC3)n(C(C)C)n1 CHEMBL3704689 IC50 0.419 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5ccc(O)c(CN6CCC(N(C)C)CC6)c5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL4567071 IC50 0.43 nM
Cc1nc(-c2cn3c(n2)-c2cc(-c4ccnn4C4CCCN(C(C)C)C4)c(F)cc2OCC3)n(C(C)C)n1 CHEMBL3704707 IC50 0.44 nM
CC(Oc1ccc2c(c1)OCCn1cc(-c3ncnn3C(C)C)nc1-2)C1CCN(C(C)C)CC1 CHEMBL3704662 IC50 0.442 nM
CC(C)c1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(OC3CN(C4CCS(=O)(=O)CC4)C3)n(C)c2n1 CHEMBL2216902 Ki 0.46 nM
Cc1nc(-c2cn3c(n2)-c2cc([C@@H](C)N4CCN(C(C)(C)C)CC4)c(C)cc2OCC3)n(C(C)C)n1 CHEMBL3704698 IC50 0.479 nM
CC(C)(C(N)=O)N1CCN(Cc2cc3nc(-c4cc(F)cc5[nH]ccc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL2165506 IC50 0.48 nM
COc1ncc(-c2ccc3ncnc(Nc4cnn(CCO)c4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4780201 IC50 0.48 nM
CN1CCN(c2nc3ccccc3cc2Cn2nc(-c3ccc4nc(N)sc4c3)c3c(N)ncnc32)CC1 CHEMBL1213118 IC50 0.5 nM
C[C@H](Nc1ncnc2[nH]cnc12)c1cc2cccc(Cl)c2nc1-c1cscn1 CHEMBL2216889 IC50 0.5 nM
Cc1c(F)cncc1-n1c([C@H](C)Nc2nc(N)nc(N)c2C#N)nc2cccc(Cl)c2c1=O CHEMBL3909674 IC50 0.5 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(Cl)ccc(Cl)c2c(=O)n1-c1ccc(N)nc1 CHEMBL3899696 IC50 0.5 nM
Cc1cc(N)ncc1-n1c([C@H](C)Nc2nc(N)nc(N)c2C#N)nc2cccc(Cl)c2c1=O CHEMBL3934385 IC50 0.5 nM
Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3-c3cncc(C(F)(F)F)c3)n(-c3ccccc3)c(=O)c12 CHEMBL3959322 IC50 0.5 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4ccnn4C4CCOCC4)c4c(N)ncnn34)c2)C(c2cccnc2)C1 CHEMBL4100063 IC50 0.5 nM
[2H]C([2H])([2H])C1([2H])N(c2cc(-c3cc(C(F)(F)F)c4c(N)ncnn34)ccc2C#N)C(=O)C(C)(C)OC1([2H])[2H] CHEMBL4089489 IC50 0.5 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(F)ccc(Cl)c2c(=O)n1-c1cncc(F)c1 CHEMBL3917562 EC50 0.5 nM
COc1ncc(-c2ccc3ncc(-c4nnc(CCN5CCN(C)CC5)o4)n3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4440406 IC50 0.5 nM
Cc1nc2sc1-c1cc3c(c(c1)S(=O)(=O)NCCCCCNC(=O)c1cccc(n1)N2)C(=O)N([C@@H](C)C1CC1)C3 CHEMBL5082066 pIC50 0.5012 nM
Cc1nc2sc1-c1cc3c(c(c1)S(=O)(=O)NCCN(C)CCNC(=O)c1cccc(n1)N2)C(=O)N([C@@H](C)C1CC1)C3 CHEMBL5081964 pIC50 0.5012 nM
CNS(=O)(=O)c1cc(-c2sc(Nc3cccc(N4CC[C@@H](O)C4=O)n3)nc2C)cc2c1C(=O)N([C@@H](C)C1CC1)C2 CHEMBL5080551 pIC50 0.5012 nM
Cc1nc(-c2cn3c(n2)-c2ccc(N4CCC[C@H]4C4CCN(C(C)C)CC4)cc2OCC3)n(C(C)C)n1 CHEMBL3704671 IC50 0.51 nM
O=C1NCc2c1cc(O[C@@H]1CCN(C(=O)C3CC(F)(F)C3)C1)cc2-c1cc(O)cc(F)c1 CHEMBL4873442 IC50 0.51 nM
CCN1CCC(C2CCCN2c2ccc3c(c2)OCCn2cc(-c4nc(C)nn4C(C)C)nc2-3)CC1 CHEMBL3704702 IC50 0.52 nM
COc1ncc(-c2cc(OC3CCOCC3)c3ncnc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4527563 IC50 0.52 nM
COc1ncc(-c2cc(O[C@@H]3CCN(C(=O)C4CC4)C3)cc3c2CNC3=O)cc1NS(C)(=O)=O CHEMBL4847971 IC50 0.54 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1cnc(N3CCCC3C3CCN(C)CC3)cc1OCC2 CHEMBL3704658 IC50 0.541 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(Cl)c3c2)cnc1Cl)c1ccccc1 CHEMBL4861043 IC50 0.55 nM
Cc1nc(-c2cn3c(n2)-c2cnc(-c4cnn(C)c4C4CCCN(C(C)C)C4)cc2OCC3)n(C(C)C)n1 CHEMBL3704741 IC50 0.571 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(OC3CN(C(=O)C(C)C)C3)n(C)c2n1 CHEMBL2216903 Ki 0.576 nM
Cc1nc(-c2cn3c(n2)-c2ccc(N4CCC[C@@H]4C4CCN(C(C)C)CC4)cc2OCC3)n(C(C)C)n1 CHEMBL3704669 IC50 0.584 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(N(C)C3CN(C4CCS(=O)(=O)CC4)C3)n(C)c2n1 CHEMBL2414297 Ki(app) 0.59 nM
COc1cc(F)c2[nH]c(-c3c(C)nn(C)c3C)c(/C=C3/Oc4ccc(NC(=O)Nc5ccc(C(=O)N(C)CCN(C)C)cc5)cc4C3=O)c2c1 CHEMBL1082621 IC50 0.6 nM
CC(C)(O)C1CCN(Cc2nc3c(N4CCOCC4)nc(-c4c(F)ccc5[nH]ccc45)nc3s2)CC1 CHEMBL2152774 IC50 0.6 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3cn(C)cn3)ccc1-2 CHEMBL2381271 IC50 0.6 nM
COCCNc1c(-c2ccccc2)c([C@H](C)Nc2ncnc(N)c2C#N)nc2ccc(F)cc12 CHEMBL3403670 IC50 0.6 nM
COc1ncc(Nc2nc3ccc(C(C)(C)O)cn3c2-c2nc(C)nc(N)n2)cc1F CHEMBL3618245 Ki 0.6 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1cccnc1 CHEMBL3928926 IC50 0.6 nM
N#Cc1c(N)nc(N)nc1N[C@H](c1nc2cccc(Cl)c2c(=O)n1-c1cccnc1)C1CC1 CHEMBL3942165 IC50 0.6 nM
N#Cc1c(N)nc(N)nc1N[C@H](c1nc2c(Cl)ccc(Cl)c2c(=O)n1-c1cccnc1)C1CC1 CHEMBL3905829 IC50 0.6 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(F)ccc(Br)c2c(=O)n1-c1cccnc1 CHEMBL3954692 IC50 0.6 nM
CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1ccc(N)nc1 CHEMBL3957355 IC50 0.6 nM
N#Cc1c(N)nc(N)nc1N[C@H](c1nc2cccc(Cl)c2c(=O)n1-c1ccc(N)nc1)C1CC1 CHEMBL3911944 IC50 0.6 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1cncc(N)c1 CHEMBL3931089 IC50 0.6 nM
Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3C(=O)Nc3ccc(O)c(F)c3)n(-c3ccccc3)c(=O)c12 CHEMBL3914643 IC50 0.6 nM
CC(=O)N1C[C@@H](C)N(c2cncc(-c3cc(-c4ccnn4C4CCOCC4)c4c(N)ncnn34)c2)[C@@H](C)C1 CHEMBL4083212 IC50 0.6 nM
C[C@H]1COC(C)(C)C(=O)N1c1cc(-c2cc(C(F)(F)F)c3c(N)ncnn23)ccc1C#N CHEMBL4077248 IC50 0.6 nM
Cc1nc(NC(=O)CNC(=O)c2ccccc2)sc1-c1cnc(Cl)c(NS(=O)(=O)c2ccccc2)c1 CHEMBL4460140 IC50 0.6 nM
CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(CNC(=O)c3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1 CHEMBL4464003 IC50 0.6 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3cnn(CCO)c3)ccc1-2 CHEMBL2381373 Ki(app) 0.61 nM
COc1ncc(-c2cc(-c3ncc(CN4CCN(C(C)C)CC4)o3)c3cn[nH]c3c2)cc1C(=O)Oc1ccc([N+](=O)[O-])cc1 CHEMBL4445040 pIC50 0.6166 nM
CN(C)CC(=O)N[C@H]1CC[C@H](Nc2nc(N3CCOCC3)nc(-n3c(C(F)F)nc4ccccc43)n2)CC1 CHEMBL2216881 IC50 0.62 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C)c4C4CC(N(C)C)CCO4)cc2OCC3)n(C(C)C)n1 CHEMBL3704694 IC50 0.63 nM
Oc1cccc(-c2nc(N3CCOCC3)c3sc(CN4CC[C@H]5[C@H](CCc6nnc(C(F)(F)F)n65)C4)cc3n2)c1 CHEMBL4096987 pIC50 0.631 nM
Cc1nc2sc1-c1cc3c(c(c1)S(=O)(=O)NCCN(C)CCCNC(=O)c1cccc(n1)N2)C(=O)N([C@@H](C)C1CC1)C3 CHEMBL5090799 pIC50 0.631 nM
Cc1nc2sc1-c1cc3c(c(c1)S(=O)(=O)NCCOCCNC(=O)c1cccc(n1)N2)C(=O)N([C@@H](C)C1CC1)C3 CHEMBL5091438 pIC50 0.631 nM
Cc1nc(Nc2cccc(N3CCCC3=O)n2)sc1-c1cc2c(c(S(C)(=O)=O)c1)C(=O)N([C@@H](C)C1CC1)C2 CHEMBL4558527 pIC50 0.631 nM
Cc1nc(Nc2cccc(N3CCNC3=O)n2)sc1-c1cc2c(c(S(=O)(=O)NC3COC3)c1)C(=O)N([C@@H](C)C1CC1)C2 CHEMBL5094877 pIC50 0.631 nM
CNS(=O)(=O)c1cc(-c2sc(Nc3cccc(N4CCOCC4=O)n3)nc2C)cc2c1C(=O)N([C@@H](C)C1CC1)C2 CHEMBL5071394 pIC50 0.631 nM
CNS(=O)(=O)c1cc(-c2sc(Nc3cccc(N4CCCOC4=O)n3)nc2C)cc2c1C(=O)N([C@@H](C)C1CC1)C2 CHEMBL5086461 pIC50 0.631 nM
Cc1nc(-c2cn3c(n2)-c2ccc(OC4(C)CNC4)cc2OCC3)n(C(C)C)n1 CHEMBL3704675 IC50 0.633 nM
Cc1nc(-c2cn3c(n2)-c2ccc(OC4(C)CCN(C(C)C)C4)cc2OCC3)n(C(C)C)n1 CHEMBL3704667 IC50 0.638 nM
Oc1cccc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL1910998 IC50 0.65 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(-c4cnc(N5CCOCC5)nc4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4871838 IC50 0.65 nM
Cc1nc(-c2cn3c(n2)-c2cc(-c4cnn(C)c4C4CC(N(C)C)CCO4)c(F)cc2OCC3)n(C(C)C)n1 CHEMBL3704731 IC50 0.66 nM
CC(C)(C(N)=O)N1CCN(Cc2cc3nc(-c4cncc5[nH]ccc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL2165512 IC50 0.67 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(N4CCCCC4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4876806 IC50 0.67 nM
Cc1nc(-c2cn3c(n2)-c2cc([C@H](C)N4CCN(C(C)C)CC4)c(C)cc2OCC3)n(C(C)C)n1 CHEMBL3704715 IC50 0.678 nM
Cc1nc(N)ncc1-c1nc(N2CCOCC2)c2sc(CN3CCN(S(C)(=O)=O)CC3)cc2n1 CHEMBL1085177 IC50 0.7 nM
Cc1ccccc1-n1c(Cn2nc(-c3cc(O)cc(F)c3)c3c(N)ncnc32)nc2cccc(C)c2c1=O CHEMBL1213084 IC50 0.7 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(Cl)ccc(Cl)c2c(=O)n1-c1cccnc1 CHEMBL3942725 IC50 0.7 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cc(O)cc(NS(=O)(=O)c6ccc(O)cc6)c5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3925216 IC50 0.7 nM
CCOc1ncc(-c2c(N)ncnc2N[C@@H](C)c2nn3ccc(C)c3c(=O)n2-c2ccccc2)cc1NS(=O)(=O)c1ccc(O)cc1 CHEMBL3972876 IC50 0.7 nM
C[C@@H]1OC(C)(C)C(=O)N(c2cc(-c3cc(C(F)(F)F)c4c(N)ncnn34)ccc2C#N)[C@H]1C CHEMBL4071039 IC50 0.7 nM
Cc1nc(N)nc(N[C@@H](C)c2nc3ccn(C)c3cc2N2CCNCC2)c1C#N CHEMBL4557936 IC50 0.7 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCCN(C(=O)c5cccnc5)C4)c3c2)cc1C#N CHEMBL4468088 IC50 0.7 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(CNC(=O)c3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1 CHEMBL4522666 IC50 0.7 nM
CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(-c3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1 CHEMBL4563838 IC50 0.7 nM
CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(CCCCCC(=O)NO)c2c(=O)n1-c1ccccc1 CHEMBL4550648 IC50 0.7 nM
O=C1NCc2c1cc(O[C@@H]1CCN(C(=O)C3CC3)C1)cc2-c1cnc(F)c(O)c1 CHEMBL4877330 IC50 0.7 nM
CC(C)n1nc(N)nc1-c1cn2c(n1)-c1ccc(-c3ccnn3C3CCN(C)CC3)cc1OCC2 CHEMBL3704697 IC50 0.705 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1cnc(N3CCCC3CN3CCCC3)cc1OCC2 CHEMBL3704657 IC50 0.707 nM
O=C1NCc2c1cc(O[C@@H]1CCN(C(=O)C3CCOCC3)C1)cc2-c1cc(O)cc(F)c1 CHEMBL4878320 IC50 0.74 nM
CCN(CC)C1CCOC(c2c(-c3ccc4c(c3)OCCn3cc(-c5nc(C)nn5C(C)C)nc3-4)cnn2C)C1 CHEMBL3704716 IC50 0.771 nM
Cc1nc(-c2cn3c(n2)-c2cc([C@@H](C)N4CCN(C(C)(C)C)CC4)c(F)cc2OCC3)n(C(C)C)n1 CHEMBL3704693 IC50 0.777 nM
COc1cc2c(cc1[C@H](C)N1CCN(C(C)(C)C)CC1)-c1nc(-c3nc(C)nn3C(C)C)cn1CCO2 CHEMBL3704733 IC50 0.784 nM
Cc1csc2cc([C@H](C)Nc3ncnc(N)c3C#N)c(-c3ccccc3)c(=O)n12 CHEMBL4073594 pIC50 0.7943 nM
FC(F)(F)c1nnc2n1[C@H]1CCN(Cc3cc4nc(-c5cccc6[nH]ccc56)nc(N5CCOCC5)c4s3)C[C@H]1CC2 CHEMBL4068538 pIC50 0.7943 nM
Cc1nnc2n1[C@H]1CCN(Cc3cc4nc(-c5cccc6[nH]ccc56)nc(N5CCOCC5)c4s3)C[C@H]1CC2 CHEMBL4081998 pIC50 0.7943 nM
Cc1nnc2n1[C@H]1CCN(Cc3cc4nc(-c5cccc(O)c5)nc(N5CCOCC5)c4s3)C[C@@H]1CC2 CHEMBL4094734 pIC50 0.7943 nM
Cc1nnc2n1[C@@H]1CCN(Cc3cc4nc(-c5cccc6[nH]ccc56)nc(N5CCOCC5)c4s3)C[C@@H]1CC2 CHEMBL4541013 pIC50 0.7943 nM
Cc1nc2sc1-c1cc3c(c(c1)S(=O)(=O)Nc1ccc(cc1)CN(C)CCCNC(=O)c1cccc(n1)N2)C(=O)N([C@@H](C)C1CC1)C3 CHEMBL5087061 pIC50 0.7943 nM
CNS(=O)(=O)c1cc(-c2sc(Nc3cccc(N(C)C(C)=O)n3)nc2C)cc2c1C(=O)N([C@@H](C)C1CC1)C2 CHEMBL5089084 pIC50 0.7943 nM
Cc1nc(Nc2cccc(N3CCCC3=O)n2)sc1-c1cc2c(c(S(=O)(=O)NC3COC3)c1)C(=O)N([C@@H](C)C1CC1)C2 CHEMBL5094364 pIC50 0.7943 nM
Cc1nc(Nc2cccc(N3CCN(C)C3=O)n2)sc1-c1cc2c(c(S(C)(=O)=O)c1)C(=O)N([C@@H](C)C1CC1)C2 CHEMBL5088457 pIC50 0.7943 nM
CNS(=O)(=O)c1cc(-c2sc(Nc3cccc(N4CCNCC4=O)n3)nc2C)cc2c1C(=O)N([C@@H](C)C1CC1)C2 CHEMBL5072469 pIC50 0.7943 nM
CC(=O)Nc1cn2nc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)ccc2n1 CHEMBL1822054 Ki 0.8 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C(=O)N3CCN(C(C)(C)C(N)=O)CC3)n(C)c2n1 CHEMBL2414294 Ki(app) 0.8 nM
COc1c(-c2ccccc2)c([C@H](C)Nc2ncnc(N)c2C#N)nc2ccc(F)cc12 CHEMBL3403665 IC50 0.8 nM
Cc1cccc2nc([C@H](C)Nc3nc(N)nc(N)c3C#N)n(-c3cncc(F)c3)c(=O)c12 CHEMBL3921732 IC50 0.8 nM
Cc1cncc(-n2c([C@H](C)Nc3nc(N)nc(N)c3C#N)nc3cccc(Cl)c3c2=O)c1C CHEMBL3935702 IC50 0.8 nM
CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1cnc(N)cc1C CHEMBL3943356 IC50 0.8 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1ccc(N)nc1 CHEMBL3962159 IC50 0.8 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cc(NS(C)(=O)=O)cc(N(C)C)c5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3936115 IC50 0.8 nM
Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3-c3cc(NS(=O)(=O)c4ccc(O)cc4)c4cc[nH]c4c3)n(-c3ccccc3)c(=O)c12 CHEMBL3905176 IC50 0.8 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4ccnn4C4CCOCC4)c4c(N)ncnn34)c2)C(C(F)(F)F)C1 CHEMBL4097699 IC50 0.8 nM
Nc1ncnn2c(-c3ccnc(N4CCN(C5COC5)CC4)c3)cc(-c3ccnn3C3CCOCC3)c12 CHEMBL4072054 IC50 0.8 nM
C[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 CHEMBL3805348 IC50 0.8 nM
C[C@@H]1COC(C)(C)C(=O)N1c1cc(-c2cc(Cl)c3c(N)ncnn23)ccc1C#N CHEMBL4065999 IC50 0.8 nM
C[C@H]1CN(c2cc(-c3cc(Cl)c4c(N)ncnn34)ccc2C#N)C(=O)C(C)(C)O1 CHEMBL4105636 IC50 0.8 nM
C[C@@H]1OC(C)(C)C(=O)N(c2cc(-c3cc(C(F)(F)F)c4c(N)ncnn34)ccc2C#N)[C@@H]1C CHEMBL4081613 IC50 0.8 nM
Cn1nc(-c2cnc(N)c(-c3ccc(C(N)=O)c(F)c3)n2)nc1C1(c2ccccc2)CC1 CHEMBL4101902 IC50 0.8 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2c(C(=O)N(C)C)c1-c1ccccc1 CHEMBL4570159 IC50 0.8 nM
COc1ccc(-c2nn([C@@H](C)c3nn(-c4cccnc4)c4cc(Cl)ccc34)c3ncnc(N)c23)cc1F CHEMBL5405825 IC50 0.8 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1cc([S@@+]([O-])C3CCN(C(C)(C)C)CC3)ccc1OCC2 CHEMBL4175041 Ki(app) 0.81 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1cc([S+]([O-])C3CCN(C(C)(C)C)CC3)ccc1OCC2 CHEMBL3704674 IC50 0.811 nM
O=S(=O)(Nc1cc(-c2ccc3ncc(N4CCNCC4)nc3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL5220248 IC50 0.83 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(N4CCOCC4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4850400 IC50 0.85 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C)c4C4CCCCN4CC(C)(C)O)cc2OCC3)n(C(C)C)n1 CHEMBL3704690 IC50 0.852 nM
Cc1nc(-c2cn3c(n2)-c2cc([C@@H](C)N4CCN(C(C)C)CC4)c(C)cc2OCC3)n(C(C)C)n1 CHEMBL3704714 IC50 0.865 nM
COc1ncc(-c2ccc3ncc(NC(=O)CN4CCOCC4)c(OC)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4083504 IC50 0.87 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(N4CCCC4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4845684 IC50 0.87 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4cn(C)nc4C4CCCN(C(C)C)C4)cc2OCC3)n(C(C)C)n1 CHEMBL3704683 IC50 0.878 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(NC3CN(C(=O)C(C)C)C3)n(C)c2n1 CHEMBL2414300 Ki(app) 0.88 nM
Cc1nc(-c2cn3c(n2)-c2cc([C@H](C)N4CCN(C(C)(C)C)CC4)c(C)cc2OCC3)n(C(C)C)n1 CHEMBL3704699 Ki(app) 0.88 nM
Cc1nc(N)nc(N[C@@H](C)c2cc3ccc(F)cn3c(=O)c2-c2ccccc2)c1C#N CHEMBL4787382 IC50 0.89 nM
CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cccc(O)c4)nc(N4CCOCC4)c3s2)CC1 CHEMBL1086923 IC50 0.9 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(NC3CN(C4CCS(=O)(=O)CC4)C3)n(C)c2n1 CHEMBL2414298 Ki(app) 0.9 nM
CC(=O)N1C[C@@H](C)N(c2cc(F)cc(-c3cc(-c4ccnn4C4CCOCC4)c4c(N)ncnn34)c2)[C@@H](C)C1 CHEMBL4091002 IC50 0.9 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4ccnn4C4CCOCC4)c4c(N)ncnn34)c2)C(c2ccccc2)C1 CHEMBL4079663 IC50 0.9 nM
Nc1ncnn2c(-c3cccc(N4CCN(C5COC5)CC4)c3)cc(-c3ccnn3C3CCOCC3)c12 CHEMBL4090888 IC50 0.9 nM
C[C@H]1COC(C)(C)C(=O)N1c1cc(-c2cc(Cl)c3c(N)ncnn23)ccc1C#N CHEMBL4077544 IC50 0.9 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1cc(C(=O)N3CCN(C(C)(C)C)CC3)ccc1OCC2 CHEMBL3704661 IC50 0.919 nM
COc1c([C@H](C)n2nc(C)c3c(N)ncnc32)cc(Cl)c(C)c1-c1ccnc(C(=O)N(C)C)c1 CHEMBL4458634 IC50 0.93 nM
Cc1nc(-c2cn3c(n2)-c2ccc(OC4(CC5CC5)CN(C(C)C)C4)cc2OCC3)n(C(C)C)n1 CHEMBL3704686 IC50 0.936 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C)c4C4CC(N(C)C(C)C)CCO4)cc2OCC3)n(C(C)C)n1 CHEMBL3704718 IC50 0.939 nM
Cc1ncc(-c2cc(O[C@@H]3CCN(C(=O)C4CC4)C3)cc3c2CNC3=O)cc1NS(C)(=O)=O CHEMBL4852562 IC50 0.94 nM
Cc1nc(-c2cn3c(n2)-c2ccc(N4CCCC4C4CCN(CC(C)(C)O)CC4)cc2OCC3)n(C(C)C)n1 CHEMBL3704676 IC50 0.986 nM
COc1c([C@H](C)Nc2ncnc(N)c2C#N)cc(Cl)c(C)c1-c1cncc(S(C)(=O)=O)c1 CHEMBL4438376 IC50 0.99 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C)c4C4CN(C(C)C)CCO4)cc2OCC3)n(C(C)C)n1 CHEMBL3704742 IC50 0.992 nM
CC(=O)Nc1nc2ccc(-c3nn(Cc4cc5ccccc5nc4N4CCN(C)CC4)c4ncnc(N)c34)cc2s1 CHEMBL1213117 IC50 1.0 nM
COc1ccc(Nc2ncc(Cc3ccc(S(C)(=O)=O)cc3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165007 Ki 1.0 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCN(C(C)(C)C)CC3)n(C)c2n1 CHEMBL2171940 IC50 1.0 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCC(C(C)(C)O)CC3)sc2n1 CHEMBL2171946 IC50 1.0 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(F)c2c(=O)n1-c1cc(F)cc(F)c1 CHEMBL3805738 EC50 1.0 nM
Cc1cncc(-n2c([C@H](C)Nc3nc(N)nc(N)c3C#N)nc3cccc(Cl)c3c2=O)c1 CHEMBL3896596 IC50 1.0 nM
CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(F)ccc(Cl)c2c(=O)n1-c1cccnc1 CHEMBL3900451 IC50 1.0 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(Cl)ccc(Cl)c2c(=O)n1-c1cncc(F)c1 CHEMBL3914829 IC50 1.0 nM
Cc1ncccc1-n1c([C@H](C)Nc2nc(N)nc(N)c2C#N)nc2cccc(Cl)c2c1=O CHEMBL3894708 IC50 1.0 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(F)ccc(Br)c2c(=O)n1-c1cncc(F)c1 CHEMBL3958629 IC50 1.0 nM
CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(F)ccc(Br)c2c(=O)n1-c1cccnc1 CHEMBL3909181 IC50 1.0 nM
CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1cncc(F)c1C CHEMBL3966390 IC50 1.0 nM
Cc1c(F)cncc1-n1c([C@H](C)Nc2nc(N)nc(N)c2C#N)nc2c(F)ccc(Cl)c2c1=O CHEMBL3964528 IC50 1.0 nM
Cc1cc(N)ncc1-n1c([C@H](C)Nc2nc(N)nc(N)c2C#N)nc2c(Cl)ccc(Cl)c2c1=O CHEMBL3921986 IC50 1.0 nM
CCC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1ccc(N)nc1 CHEMBL3956754 IC50 1.0 nM
N#Cc1c(N)nc(N)nc1N[C@H](c1nc2c(F)ccc(Cl)c2c(=O)n1-c1ccc(N)nc1)C1CC1 CHEMBL3908617 IC50 1.0 nM
N#Cc1c(N)ncnc1N[C@@H](CCOc1ccccc1)c1nn2cccc2c(=O)n1-c1ccccc1 CHEMBL3905787 IC50 1.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cc(O)cc(F)c5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3901855 IC50 1.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cccc6[nH]ncc56)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3922483 IC50 1.0 nM
COc1ncc(-c2c(N)ncnc2N[C@@H](C)c2nn3ccc(C)c3c(=O)n2-c2ccccc2)cc1NS(=O)(=O)C(F)(F)F CHEMBL3954751 IC50 1.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cccc(Cl)c5O)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3937301 IC50 1.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3-c3cnn(CCO)c3)n(-c3ccccc3)c(=O)c12 CHEMBL3922886 IC50 1.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3-c3cc(O)cc(NS(=O)(=O)c4ccc(F)cc4F)c3)n(-c3ccccc3)c(=O)c12 CHEMBL3907104 IC50 1.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cc(O)cc(NS(=O)(=O)CCN(C)C)c5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3952760 IC50 1.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3-c3cc(O)cc(C(=O)N(C)C)c3)n(-c3ccccc3)c(=O)c12 CHEMBL3905026 IC50 1.0 nM
C[C@H](Nc1ncnc2[nH]cc(-c3cc(NS(C)(=O)=O)cc(OS(C)(=O)=O)c3)c12)c1nn2cccc2c(=O)n1-c1ccccc1 CHEMBL3904698 IC50 1.0 nM
Cc1csc2cc([C@H](C)Nc3ncnc(N)c3C#N)c(-c3cccc(CN4CCN(CCN5CCOCC5)CC4)c3)c(=O)n12 CHEMBL4061810 pIC50 1.0 nM
CC(=O)N1CCN(c2cc(-c3cc(Cl)c4c(N)ncnn34)ccc2C#N)C(=O)C1(C)C CHEMBL4074315 IC50 1.0 nM
C[C@@H]1CN(c2cc(-c3cc(Cl)c4c(N)ncnn34)ccc2C#N)C(=O)C(C)(C)O1 CHEMBL4101245 IC50 1.0 nM
C[C@H]1CN(c2cc(-c3cc(C(F)(F)F)c4c(N)ncnn34)ccc2C#N)C(=O)C(C)(C)O1 CHEMBL4072098 IC50 1.0 nM
CC[C@@H]1CN(c2cc(-c3cc(C(F)(F)F)c4c(N)ncnn34)ccc2C#N)C(=O)C(C)(C)O1 CHEMBL4076745 IC50 1.0 nM
Oc1cccc(-c2nc(N3CCOCC3)c3sc(CN4CC[C@H]5[C@@H](CCc6nnc(C(F)(F)F)n65)C4)cc3n2)c1 CHEMBL4071462 pIC50 1.0 nM
Cc1nnc2n1[C@H]1CCN(Cc3cc4nc(-c5cccc6[nH]ccc56)nc(N5CCOCC5)c4s3)C[C@@H]1CC2 CHEMBL4061794 pIC50 1.0 nM
CC(=O)Nc1nc(C)c(-c2cnc(Cl)c(NS(=O)(=O)c3ccccc3)c2)s1 CHEMBL4174132 IC50 1.0 nM
Cc1nc(NC(=O)[C@@H](N)C(C)C)sc1-c1cnc(Cl)c(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1 CHEMBL4175347 IC50 1.0 nM
Cc1nc(N)nc(N[C@@H](C)c2c(-c3ccccc3)c(=O)n3cc(F)ccc3c2-c2ccc(F)cc2)c1C#N CHEMBL4463183 IC50 1.0 nM
CCOc1c([C@H](C)n2nc(C)c3c(N)ncnc32)cc(Cl)c(F)c1[C@@H]1CNC(=O)C1 CHEMBL4297615 IC50 1.0 nM
O=c1c2c(Cl)ccn2nc([C@@H]2C[C@H](F)CN2c2ncnc3[nH]cnc23)n1-c1ccccc1 CHEMBL4548876 IC50 1.0 nM
Cc1ncc(-c2ccn3ncc(-c4ccc5c(c4)[C@](C)(Cc4ccccc4)C(=O)N5)c3n2)cn1 CHEMBL4452905 IC50 1.0 nM
CN(C)C1(c2cccc(-c3cc(-c4ccnn4C4CCOCC4)c4c(N)ncnn34)c2)COC1 CHEMBL4549504 IC50 1.0 nM
CC(C)C(=O)N1C[C@H](O)C[C@H]1c1cccc(-c2cc(-c3ccnn3C3CCOCC3)c3c(N)ncnn23)c1 CHEMBL4469521 IC50 1.0 nM
COc1ncc(-c2nc3c(N4CCOCC4)ncnc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4798343 IC50 1.0 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2n1-c1cccnc1 CHEMBL4763849 fIC50 1.0 nM
O=S(=O)(Nc1cc(-c2cnc3[nH]ccc3c2)cnc1Cl)c1ccccc1 CHEMBL4214320 IC50 1.0 nM
O=S(=O)(Nc1cc(-c2cnc3[nH]ncc3c2)cnc1Cl)c1ccccc1 CHEMBL4204119 IC50 1.0 nM
Cc1nc2sc1-c1cc3c(c(c1)S(=O)(=O)Nc1ccc(cc1)CN(C)CCCCNC(=O)c1cccc(n1)N2)C(=O)N([C@@H](C)C1CC1)C3 CHEMBL5081634 pIC50 1.0 nM
CNS(=O)(=O)c1cc(-c2sc(Nc3cccc(N4CCCCC4=O)n3)nc2C)cc2c1C(=O)N([C@@H](C)C1CC1)C2 CHEMBL5076543 pIC50 1.0 nM
Cc1nc(Nc2cccc(N3CCOCC3=O)n2)sc1-c1cc2c(c(S(C)(=O)=O)c1)C(=O)N([C@@H](C)C1CC1)C2 CHEMBL5088310 pIC50 1.0 nM
Cc1nc(Nc2cccc(N3CCOCC3=O)n2)sc1-c1cc2c(c(S(=O)(=O)NC3COC3)c1)C(=O)N([C@@H](C)C1CC1)C2 CHEMBL5077865 pIC50 1.0 nM
Nc1ncnc2c1c(-c1cc(O)c(Br)c(F)c1)nn2[C@H]1CCc2ccccc21 CHEMBL5283460 IC50 1.0 nM
CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(F)c2c(=O)n1-c1ccccc1 CHEMBL2216870 IC50 1.0 nM
COc1ccc(CNc2cnnc3ccc(-c4cnc(Cl)c(NS(=O)(=O)c5ccccc5)c4)cc23)cc1 CHEMBL4865798 IC50 1.02 nM
Cc1ccc(S(C)(=O)=O)c(-c2nc3cc(F)cc(F)c3c(N3CC(C)(C)c4ncc(N5CCOCC5)cc43)c2C)c1 CHEMBL2216891 Ki 1.05 nM
COc1cc2c(cc1[C@@H](C)N1CCN(C(C)(C)C)CC1)-c1nc(-c3nc(C)nn3C(C)C)cn1CCO2 CHEMBL3704732 IC50 1.05 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4ccnn4C4CCN(C(C)C)CC4)cc2OCC3)n(C(C)C)n1 CHEMBL3704695 IC50 1.06 nM
Cc1cc2c(-c3nc(N4CCOCC4)c4sc(CN5CCN(C(C)(C)C(N)=O)CC5)cc4n3)cccc2[nH]1 CHEMBL2165509 IC50 1.1 nM
COc1cnc(Nc2cnc(Cl)c(NS(=O)(=O)N(C)C)c2)c(-c2nc(C)nc(N)n2)c1 CHEMBL2206904 Ki 1.1 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CCNC3)ccc1-2 CHEMBL2381266 IC50 1.1 nM
CC(C)(O)C1CCN(Cc2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL2414238 Ki(app) 1.1 nM
CC(=O)N1CCN(c2cc(-c3cc(Cl)c4c(N)ncnn34)ccc2C)C(=O)C1(C)C CHEMBL4067315 IC50 1.1 nM
CC(=O)N1C[C@H](C)N(c2cc(-c3cc(C(F)(F)F)c4c(N)ncnn34)ccc2C#N)C(=O)C1(C)C CHEMBL4071965 IC50 1.1 nM
CC1(C)OCCN(c2cc(-c3cc(Cl)c4c(N)ncnn34)ccc2C#N)C1=O CHEMBL4092654 IC50 1.1 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(C(=O)C4CC4)CC3=O)cc2n1 CHEMBL4788952 IC50 1.1 nM
COc1cnnc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccccc4)c3)cc12 CHEMBL4846935 IC50 1.1 nM
Cc1nc(-c2cn3c(n2)-c2ccc(N4CCCC4C4CCN(S(C)(=O)=O)CC4)cc2OCC3)n(C(C)C)n1 CHEMBL3704704 IC50 1.18 nM
CC(=O)Nc1nc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)cc2s1 CHEMBL1615189 Ki 1.2 nM
Cc1nc(N)nc(-c2cccnc2Nc2cnc(Cl)c(NS(C)(=O)=O)c2)n1 CHEMBL2206913 Ki 1.2 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2c(N2CCOCC2)c1-c1ccccn1 CHEMBL3403676 IC50 1.2 nM
COc1cc(-c2cc(-c3ccnn3C3CCOCC3)c3c(N)ncnn23)cc(N2[C@H](C)CN(C(C)=O)C[C@@H]2C)c1 CHEMBL4070023 IC50 1.2 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4ccnn4C4CCOCC4)c4c(N)ncnn34)c2)CC1c1cccnc1 CHEMBL4091410 IC50 1.2 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1cc(S(=O)(=O)N3CCN(C(C)(C)C)CC3)ccc1OCC2 CHEMBL4167171 Ki(app) 1.2 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2c(C(=O)N2CCS(=O)(=O)CC2)c1-c1ccccc1 CHEMBL4449366 IC50 1.2 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(S(=O)(=O)C4CC4)CC3=O)cc2n1 CHEMBL4787716 IC50 1.2 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1cncc(F)c1 CHEMBL3982635 EC50 1.2 nM
CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nn(-c2cccnc2)c2cc(Cl)ccc12 CHEMBL5199080 IC50 1.2 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCN(C(=O)C4CCC4)CC3=O)n(C)c2n1 CHEMBL5272165 IC50 1.2 nM
Cc1ccccc1-n1c([C@H](C)n2cnc3c(N)ncnc32)nc2cccc(C)c2c1=O CHEMBL4069027 pIC50 1.259 nM
Cc1csc2cc([C@H](C)Nc3ncnc(N)c3C#N)c(Cc3cccc(CNCCCCOCCc4ccccc4)c3)c(=O)n12 CHEMBL4060741 pIC50 1.259 nM
Cc1csc2cc([C@H](C)Nc3ncnc(N)c3C#N)c(-c3cccc(CN4CCC(N(C)CC(C)C)CC4)c3)c(=O)n12 CHEMBL4094000 pIC50 1.259 nM
CCN(CCN1CCOCC1)Cc1cccc(-c2c([C@H](C)Nc3ncnc(N)c3C#N)cc3scc(C)n3c2=O)c1 CHEMBL4101730 pIC50 1.259 nM
COc1ncc(C2=CCOCC2)cc1S(=O)(=O)Nc1cncc(-c2ccc(CN3C[C@@H](C)N(C)[C@@H](C)C3)cc2)c1 CHEMBL4858875 pIC50 1.259 nM
CC(=O)N(C)c1cccc(Nc2nc(C)c(-c3cc4c(c(S(C)(=O)=O)c3)C(=O)N([C@@H](C)C3CC3)C4)s2)n1 CHEMBL5071188 pIC50 1.259 nM
CNS(=O)(=O)c1cc(-c2sc(Nc3cccc(N4C[C@H](O)CC4=O)n3)nc2C)cc2c1C(=O)N([C@@H](C)C1CC1)C2 CHEMBL5094025 pIC50 1.259 nM
Cc1nc(Nc2cccc(N3CCCCC3=O)n2)sc1-c1cc2c(c(S(C)(=O)=O)c1)C(=O)N([C@@H](C)C1CC1)C2 CHEMBL5084056 pIC50 1.259 nM
Cc1nc(Nc2cccc(N3CCCOC3=O)n2)sc1-c1cc2c(c(S(C)(=O)=O)c1)C(=O)N([C@@H](C)C1CC1)C2 CHEMBL5091128 pIC50 1.259 nM
Cc1cccc(-c2c([C@H](C)Nc3nc(N)nc(N)c3C#N)cc3ccc(F)cn3c2=O)c1 CHEMBL4754291 IC50 1.28 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CCNCC3)ccc1-2 CHEMBL2381268 IC50 1.3 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2c(C#N)c1-c1ccccc1 CHEMBL3403668 IC50 1.3 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4ccnn4C4CC(C)N(C)C(C)C4)cc2OCC3)n(C(C)C)n1 CHEMBL3704685 IC50 1.3 nM
CC(=O)N1C[C@@H](C)N(c2cccc(-c3cc(-c4ccnn4C4CCOCC4)c4c(N)ncnn34)c2)[C@@H](C)C1 CHEMBL4061855 IC50 1.3 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4ccnn4C4CCOCC4)c4c(N)ncnn34)c2)C(c2ccc(Cl)cc2)C1 CHEMBL4073217 IC50 1.3 nM
CC(=O)N1C[C@@H](C)N(c2cc(-c3cc(Cl)c4c(N)ncnn34)ccc2C#N)C(=O)C1(C)C CHEMBL4095752 IC50 1.3 nM
Cc1nc(NC(=O)C2(N)CC2)sc1-c1cnc(Cl)c(NS(=O)(=O)c2ccccc2)c1 CHEMBL4164664 IC50 1.3 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCCN(C(=O)CN(C)C)C4)c3c2)cc1C#N CHEMBL4476303 IC50 1.3 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2c(C(=O)N2CC(O)C2)c1-c1ccccc1 CHEMBL4542785 IC50 1.3 nM
CNC(=O)c1c(-c2ccccc2)c([C@H](C)Nc2ncnc(N)c2C#N)nc2ccc(F)cc12 CHEMBL4516601 IC50 1.3 nM
COc1ncc(-c2ccc3nccc(/C(C)=C/C(=O)N4CCN(C)CC4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4739883 IC50 1.3 nM
Cc1nc(-c2cn3c(n2)-c2ccc(N4CCCC4C4CCCN(C)C4)cc2OCC3)n(C(C)C)n1 CHEMBL3704705 IC50 1.35 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4ccnn4C4CCCN(C5(C)COC5)C4)cc2OCC3)n(C(C)C)n1 CHEMBL3704688 IC50 1.39 nM
CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cccc(CO)c4)nc(N4CCOCC4)c3s2)CC1 CHEMBL1085160 IC50 1.4 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3ccc(N)nc3)ccc1-2 CHEMBL2381273 IC50 1.4 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2c(N2CC(O)C2)c1-c1ccccn1 CHEMBL3403675 IC50 1.4 nM
CC(Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2c(N(C)C)c1-c1ccccn1 CHEMBL3403674 IC50 1.4 nM
CC(=O)N1[C@H](C)CN(c2cccc(-c3cc(-c4ccnn4C4CCOCC4)c4c(N)ncnn34)c2)C[C@@H]1C CHEMBL4083625 IC50 1.4 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4cc(C(C)C)no4)c4c(N)ncnn34)c2)C(=O)C1(C)C CHEMBL4094693 IC50 1.4 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4nnc(C(C)C)o4)c4c(N)ncnn34)c2)C(=O)C1(C)C CHEMBL4074193 IC50 1.4 nM
C[C@@H]1COC(C)(C)C(=O)N1c1cc(-c2cc(C(F)(F)F)c3c(N)ncnn23)ccc1C#N CHEMBL4084394 IC50 1.4 nM
CC[C@H](N)C(=O)Nc1nc(C)c(-c2cnc(Cl)c(NS(=O)(=O)c3ccccc3)c2)s1 CHEMBL4168490 IC50 1.4 nM
CC(Nc1nc(N)nc(N)c1C#N)c1c(-c2ccccc2)[nH]c2c(Cl)cccc2c1=O CHEMBL4516283 IC50 1.4 nM
CCOc1c([C@H](C)n2nc(C)c3c(N)ncnc32)cc(Cl)c(C)c1C1CNC(=O)C1 CHEMBL4561896 IC50 1.4 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(C(=O)C4CCC4)CC3=O)cc2n1 CHEMBL4752490 IC50 1.4 nM
COc1ncc(-c2cc(-c3ccnc(N4C[C@@H](C)O[C@@H](C)C4)c3)cc3c2CNC3=O)cc1NS(C)(=O)=O CHEMBL4863978 IC50 1.4 nM
CCC(c1nn(-c2cccnc2)c2cc(Cl)ccc12)n1nc(-c2cnn(C)c2)c2c(N)ncnc21 CHEMBL5415728 IC50 1.4 nM
Cc1nc(-c2cn3c(n2)-c2ccc(N4CCC4C4CCN(C(C)C)CC4)cc2OCC3)n(C(C)C)n1 CHEMBL3704692 IC50 1.47 nM
Cc1nc(-c2cn3c(n2)-c2cc([C@@H](C)N4CCN(C(C)C)CC4)c(F)cc2OCC3)n(C(C)C)n1 CHEMBL3704721 IC50 1.48 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1cc2ccc(F)cn2c(=O)c1-c1ccccc1 CHEMBL4794328 IC50 1.49 nM
Cc1c(CN2CCN(C(=O)C(C)(C)N)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1922092 IC50 1.5 nM
C=CC(=O)N1CCN(S(=O)(=O)c2cccc(Nc3ncc4c(n3)N(C)c3ccc(C)cc3C(=O)N4C)c2)CC1 CHEMBL3979343 IC50 1.5 nM
C[C@@H]1CN(C(=O)CO)C[C@H](C)N1c1cccc(-c2cc(-c3ccnn3C3CCOCC3)c3c(N)ncnn23)c1 CHEMBL4064155 IC50 1.5 nM
CC(=O)N1CCN(c2cc(-c3cc(Cl)c4c(N)ncnn34)ccc2Cl)C(=O)C1(C)C CHEMBL4097222 IC50 1.5 nM
CCC(=O)N1CC[C@H](Nc2ncnc3c2CN(c2cnc(OC)c(C(F)(F)F)c2)CC3)C1 CHEMBL3643413 IC50 1.5 nM
Cc1nc(-c2cn3c(n2)-c2ccc(N4CCCC45CCCN(C(C)C)C5)cc2OCC3)n(C(C)C)n1 CHEMBL3704720 IC50 1.52 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(N4CCNCC4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4865341 IC50 1.58 nM
Cc1csc2cc([C@H](C)Nc3ncnc(N)c3C#N)c(Cc3cccc(CN(C)C)c3)c(=O)n12 CHEMBL4104746 pIC50 1.585 nM
Cc1csc2cc([C@H](C)Nc3ncnc(N)c3C#N)c(Cc3cccc(CN(C)CC(C)C)c3)c(=O)n12 CHEMBL4069417 pIC50 1.585 nM
Cc1csc2cc([C@H](C)Nc3ncnc(N)c3C#N)c(-c3cccc(CC4CCN(C(C)C)CC4)c3)c(=O)n12 CHEMBL4081062 pIC50 1.585 nM
FC(F)(F)c1nnc2n1[C@H]1CCN(Cc3cc4nc(-c5cccc6[nH]ccc56)nc(N5CCOCC5)c4s3)C[C@@H]1CC2 CHEMBL4097593 pIC50 1.585 nM
COc1ncc(-c2cc3c(c(OC[C@H]4CN(CC(C)(C)O)CCO4)c2)COC3)cc1NS(C)(=O)=O CHEMBL4518946 pIC50 1.585 nM
COc1ncc(C2=CCOCC2)cc1S(=O)(=O)Nc1cncc(C#CCN2CCN(C(C)C)CC2)c1 CHEMBL4872328 pIC50 1.585 nM
Cc1nc(-c2cccc(Nc3nc(C)c(-c4cc5c(c(S(C)(=O)=O)c4)C(=O)N([C@@H](C)C4CC4)C5)s3)n2)n(C)n1 CHEMBL5084355 pIC50 1.585 nM
CNS(=O)(=O)c1cc(-c2sc(Nc3cccc(N4CCN(C)CC4=O)n3)nc2C)cc2c1C(=O)N([C@@H](C)C1CC1)C2 CHEMBL5078679 pIC50 1.585 nM
Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3C#N)n(-c3ccccc3)c(=O)c12 CHEMBL3897116 IC50 1.6 nM
CC(=O)N1CCN(c2cc(-c3cc(Cl)c4c(N)ncnn34)ccc2C(F)(F)F)C(=O)C1(C)C CHEMBL4078237 IC50 1.6 nM
C=CCN1CCN(Cc2cc3nc(-n4c(CC)nc5ccccc54)nc(N4CCOCC4)c3s2)C(=O)C1 CHEMBL4788725 IC50 1.6 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(C4CCC(=O)CC4)CC3=O)cc2n1 CHEMBL4743492 IC50 1.6 nM
COc1ccc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@H](OCCO)CC3)c2=O)cn1 CHEMBL1234354 Ki 1.6 nM
N#Cc1c(N)nc(N)nc1N1C[C@H](OC(=O)NCc2ccc(C(=O)NO)cc2)C[C@H]1c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 CHEMBL5218671 IC50 1.6 nM
COc1ccc(-c2cc3c(C)nc(N)nc3n(C3CCC(OCCO)CC3)c2=O)cn1 CHEMBL5278357 Ki 1.6 nM
COc1ccc(-c2nn(C(C)c3nn(-c4cccnc4)c4cc(Cl)ccc34)c3ncnc(N)c23)cc1F CHEMBL5396838 IC50 1.6 nM
CC(c1nn(-c2cccnc2)c2cc(Cl)ccc12)n1nc(-c2cnn(C)c2)c2c(N)ncnc21 CHEMBL5415398 IC50 1.6 nM
CNC(=O)c1ccc2c(c1)OCCc1cc(C(=O)N(C)c3ccc(C(=O)N(C)C)cc3Cl)sc1-2 CHEMBL1796761 IC50 1.7 nM
COc1cc(N)cc2c1nc(C(F)F)n2-c1nc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL1911117 IC50 1.7 nM
CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cccc5[nH]ccc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL2165672 IC50 1.7 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2c(NCCN(C)C)c1-c1ccccc1 CHEMBL3403671 IC50 1.7 nM
CCC(=O)N1CCN(S(=O)(=O)c2cccc(Nc3ncc4c(n3)N(C)c3ccc(C)cc3C(=O)N4C)c2)CC1 CHEMBL3942643 IC50 1.7 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4ccnn4C4CCOCC4)c4c(N)ncnn34)c2)[C@@H](C)C1 CHEMBL4083101 IC50 1.7 nM
CC(=O)N1CCN(c2cc(-c3cc(C(F)(F)F)c4c(N)ncnn34)ccc2C#N)C(=O)C1(C)C CHEMBL4064666 IC50 1.7 nM
CC(=O)N1C[C@@H](C)N(c2cc(-c3cc(C(F)(F)F)c4c(N)ncnn34)ccc2C#N)C(=O)C1(C)C CHEMBL4083358 IC50 1.7 nM
COc1c([C@H](C)Nc2ncnc3[nH]cnc23)cc(Cl)c(C)c1-c1cncc(S(C)(=O)=O)c1 CHEMBL4446120 IC50 1.7 nM
C[C@H](Nc1ncnc2[nH]cnc12)c1cc2ccc(F)cc2nc1-c1ccccn1 CHEMBL4303596 fIC50 1.7 nM
Cc1cccc2cc([C@H](C)Nc3ncnc(N)c3C#N)c(-c3ccccc3)c(=O)n12 CHEMBL4787659 IC50 1.7 nM
CN(C)C1CCN(Cc2cc3nc(-c4c(F)ccc5[nH]ccc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL2165666 IC50 1.8 nM
CC(C)(C(N)=O)N1CCN(Cc2cc3nc(-c4cccc5[nH]ccc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL2165671 IC50 1.8 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCN(C(C)(C)C(N)=O)CC3)n(C)c2n1 CHEMBL2171939 Ki(app) 1.8 nM
Nc1ncnn2c(-c3ccnc(N4CCNCC4)c3)cc(-c3ccnn3C3CCOCC3)c12 CHEMBL4082528 IC50 1.8 nM
COc1c([C@H](C)Nc2ncnc(N)c2C#N)cc(Cl)c(C)c1-c1ccc(C(=O)N(C)C)cn1 CHEMBL4444112 IC50 1.8 nM
NC(=O)c1cccc2cc(C(=O)N3CCN(Cc4cc5nc(-c6cnc(N)nc6)nc(N6CCOCC6)c5s4)CC3)oc12 CHEMBL4871210 IC50 1.8 nM
O=C1NCc2c1cc(O[C@@H]1CCN(C(=O)C3CC3)C1)cc2-c1cc(O)cc(F)c1 CHEMBL4852413 IC50 1.8 nM
COc1ccc(-c2nn(C(C)c3nn(-c4cccnc4)c4cc(Cl)ccc34)c3ncnc(N)c23)cc1 CHEMBL5423819 IC50 1.8 nM
CC(C)(O)C1CCN(Cc2nc3c(N4CCOCC4)nc(-c4c(F)ccc5[nH]ccc45)nc3[nH]2)CC1 CHEMBL2152775 IC50 1.9 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(Cl)ccc(Cl)c2c(=O)n1-c1cnc(N)cn1 CHEMBL3954098 IC50 1.9 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4cnn(C5CC5)c4)c4c(N)ncnn34)c2)C(=O)C1(C)C CHEMBL4087215 IC50 1.9 nM
CC(=O)N1CCN(c2cc(-c3cc(C(F)(F)F)c4c(N)ncnn34)ccc2C(F)(F)F)C(=O)C1(C)C CHEMBL4094814 IC50 1.9 nM
CC(=O)N1CCN(c2cc(-c3cc(C(F)(F)F)c4c(N)ncnn34)ccc2S(C)(=O)=O)C(=O)C1(C)C CHEMBL4073255 IC50 1.9 nM
Cc1nc(-c2cn3c(n2)-c2cc([C@H](C)N4CCN(C(C)(C)C)CC4)ncc2OCC3)n(C(C)C)n1 CHEMBL3704701 Ki(app) 1.9 nM
Cc1ncc(-c2ccn3ncc(-c4ccc5c(c4)C(C)(CC4CC4)C(=O)N5)c3n2)cn1 CHEMBL4449778 IC50 1.9 nM
COc1ccc(Cn2c(=O)n(C)c3c4cc(-c5cnc(OC)c(NS(C)(=O)=O)c5)ccc4ncc32)cc1 CHEMBL4560054 IC50 1.9 nM
COc1c([C@H](C)n2nc(C)c3c(N)ncnc32)cc(Cl)c(C#N)c1C1CN(C[C@H](C)O)C1 CHEMBL4593387 IC50 1.9 nM
Cc1nc(-c2cn3c(n2)-c2ccc(N4CCCC4C4CCCCN4C)cc2OCC3)n(C(C)C)n1 CHEMBL3704709 IC50 1.94 nM
Cc1nc(-c2cn3c(n2)-c2cc([C@H](C)N4CCN(C(C)(C)CO)CC4)c(F)cc2OCC3)n(C(C)C)n1 CHEMBL3704728 IC50 1.99 nM
Cc1csc2cc([C@H](C)Nc3ncnc(N)c3C#N)c(-c3cccc(CN4CCC(CN(C)Cc5ccccn5)CC4)c3)c(=O)n12 CHEMBL4083733 pIC50 1.995 nM
Cc1csc2cc([C@H](C)Nc3ncnc(N)c3C#N)c(-c3cccc(CN(C)CCCCN(C)Cc4ccccc4)c3)c(=O)n12 CHEMBL4086230 pIC50 1.995 nM
Cc1nc(C(=O)Nc2cc(-c3cnc(Cl)c(NS(=O)(=O)c4ccccc4)c3)cc3[nH]ncc23)cs1 CHEMBL4576860 pIC50 1.995 nM
Cc1nc(Nc2cccc(-c3ocnc3CO)n2)sc1-c1cc2c(c(S(C)(=O)=O)c1)C(=O)N([C@@H](C)C1CC1)C2 CHEMBL5090959 pIC50 1.995 nM
COc1ccc2c(nc(C(F)F)n2-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)c1O CHEMBL1911114 IC50 2.0 nM
Cc1c(Cl)cccc1Cn1c(SCC(=O)O)nc(=O)c2sc(N3CCOCC3)nc21 CHEMBL2089119 IC50 2.0 nM
Cc1c(Cl)cccc1Cn1c(CO)nc(=O)c2sc(N3CCOCC3)nc21 CHEMBL2089114 IC50 2.0 nM
COc1ccc(Nc2ncc(CN3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165017 Ki 2.0 nM
COc1ccc(Nc2ncc(C3=CCOCC3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165030 Ki 2.0 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CC(C4CCOCC4)C3)n(C)c2n1 CHEMBL2171942 IC50 2.0 nM
CC(C)c1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCC(C(C)(C)O)CC3)n(C)c2n1 CHEMBL2171952 IC50 2.0 nM
COC(C)c1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCC(C(C)(C)O)CC3)n(C)c2n1 CHEMBL2171949 IC50 2.0 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCC(C(C)(C)O)CC3)n(C)c2n1 CHEMBL2171944 IC50 2.0 nM
Cc1cccc2nc(-c3ccccc3Cl)c(Cn3nc(C#N)c4c(N)ncnc43)nc12 CHEMBL2216888 IC50 2.0 nM
CN1CCN(Cc2cccc3c2CCN3C(=O)Cc2nc(N3CCOCC3)cc(=O)[nH]2)CC1 CHEMBL3112860 IC50 2.0 nM
CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1cccnc1 CHEMBL3897420 IC50 2.0 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(C(F)(F)F)c2c(=O)n1-c1cccnc1 CHEMBL3927130 IC50 2.0 nM
N#Cc1c(N)nc(N)nc1N[C@H](c1nc2cccc(Cl)c2c(=O)n1-c1cncc(F)c1)C1CC1 CHEMBL3948051 IC50 2.0 nM
Cc1cncc(-n2c([C@H](C)Nc3nc(N)nc(N)c3C#N)nc3c(F)ccc(Cl)c3c2=O)c1 CHEMBL3927360 IC50 2.0 nM
N#Cc1c(N)nc(N)nc1N[C@H](c1nc2c(F)ccc(Cl)c2c(=O)n1-c1cncc(F)c1)C1CC1 CHEMBL3951571 IC50 2.0 nM
C[C@H](Nc1nc(N)nc(N)c1C(N)=O)c1nc2cccc(Cl)c2c(=O)n1-c1cccnc1 CHEMBL3976101 IC50 2.0 nM
Cc1ccncc1-n1c([C@H](C)Nc2nc(N)nc(N)c2C#N)nc2cccc(C(F)(F)F)c2c1=O CHEMBL3948071 IC50 2.0 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1cncc(N)c1 CHEMBL3903107 IC50 2.0 nM
COc1ncc(-c2c[nH]c3ncnc(N[C@@H](C)c4nn5ccc(C)c5c(=O)n4-c4ccccc4)c23)cc1NS(C)(=O)=O CHEMBL3909699 IC50 2.0 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nn2ccc(Sc3ccc(O)c(F)c3)c2c(=O)n1-c1ccccc1 CHEMBL3913611 IC50 2.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(Sc5ccc(O)cc5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3968495 IC50 2.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cnn(CCN(C)C)c5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3948478 IC50 2.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3-c3cncc(OCC(F)(F)F)c3)n(-c3ccccc3)c(=O)c12 CHEMBL3974496 IC50 2.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5ccn(CCN6CCOCC6)n5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3960519 IC50 2.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3-c3cccc(C(=O)Nc4cccc(O)c4)c3)n(-c3ccccc3)c(=O)c12 CHEMBL3890258 IC50 2.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5ccc(NS(=O)(=O)N(C)C)cc5O)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3898556 IC50 2.0 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1cnc(N)cn1 CHEMBL3913858 IC50 2.0 nM
CN1CCN(c2cccc(-c3cc(-c4ccnn4C4CCOCC4)c4c(N)ncnn34)c2)CC1 CHEMBL4062954 IC50 2.0 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4ccnn4C4CC4)c4c(N)ncnn34)c2)C(=O)C1(C)C CHEMBL4081766 IC50 2.0 nM
CC(=O)N1CCN(c2cccc(-c3cc(I)c4c(N)ncnn34)c2)C(=O)C1(C)C CHEMBL4093883 IC50 2.0 nM
Cc1nc(NC(=O)[C@@H](N)C(C)C)sc1-c1cnc(Cl)c(NS(=O)(=O)c2cccc(Cl)c2Cl)c1 CHEMBL4165122 IC50 2.0 nM
Cc1nc(NC(=O)[C@@H](N)C(C)C)sc1-c1cnc(Cl)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1 CHEMBL4167465 IC50 2.0 nM
Cc1ccc2c(c1)C(=O)N(C)c1cnc(Nc3cccc(S(=O)(=O)N4CCC(O)CC4)c3)nc1N2C CHEMBL3959351 IC50 2.0 nM
N#Cc1c[nH]c2ncnc(N3CCC[C@H]3c3nn4cccc4c(=O)n3-c3ccccc3)c12 CHEMBL4530831 IC50 2.0 nM
CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 CHEMBL4440839 IC50 2.0 nM
Nc1ncnn2c(-c3cccc(C(=O)N4CCCC4)c3)cc(-c3ccnn3C3CCCCC3)c12 CHEMBL4450960 IC50 2.0 nM
Nc1ncnn2c(-c3cccc(CN4CCOCC4)c3)cc(-c3ccnn3C3CCOCC3)c12 CHEMBL4446562 IC50 2.0 nM
CN(C)C(C)(C)c1cccc(-c2cc(-c3ccnn3C3CCOCC3)c3c(N)ncnn23)c1 CHEMBL4576417 IC50 2.0 nM
CC(C)[C@H]1COC(=O)N1Cc1cccc(-c2cc(-c3ccnn3C3CCOCC3)c3c(N)ncnn23)c1 CHEMBL4592486 IC50 2.0 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2c(C(N)=O)c1-c1ccccc1 CHEMBL4555334 IC50 2.0 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(C(=O)C4CCCC4)CC3=O)cc2n1 CHEMBL4762689 IC50 2.0 nM
CCC(=O)N1CC[C@H](Nc2ncnc3c2nc(-c2cnn(CC)c2C)n3CC)C1 CHEMBL4849371 IC50 2.0 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nn(-c2cccnc2)c2cc(Cl)ccc12 CHEMBL5187387 IC50 2.0 nM
O=C1NC(=O)/C(=C/c2ccc3nccc(-c4ccncc4)c3c2)S1 CHEMBL3544966 IC50 2.0 nM
Cc1nc(-c2cn3c(n2)-c2cc([C@H](C)N4CCN(C(C)(C)CO)CC4)ncc2OCC3)n(C(C)C)n1 CHEMBL3704736 IC50 2.1 nM
CC(=O)N1CCN(c2cccc(-c3cc(Br)c4c(N)ncnn34)c2)C(=O)C1(C)C CHEMBL4066316 IC50 2.1 nM
Cc1nc(NC(=O)[C@H](C)N)sc1-c1cncc(NS(=O)(=O)c2ccccc2)c1 CHEMBL4161316 IC50 2.1 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(C4CCCC4)C(=O)C3)cc2n1 CHEMBL4750636 IC50 2.1 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN([C@H]4CC[C@H](O)CC4)C(=O)C3)cc2n1 CHEMBL4796048 IC50 2.1 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(c4nccs4)C(=O)C3)cc2n1 CHEMBL4741654 IC50 2.1 nM
CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nn(-c2cccnc2)c2cc(F)ccc12 CHEMBL5207398 IC50 2.1 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nn(-c2cccc(S(C)(=O)=O)c2)c2cc(Cl)ccc12 CHEMBL5183574 IC50 2.1 nM
COc1ccc(-c2cc(Cl)c3c(N)ncnn23)cc1N1CCN(C(C)=O)C(C)(C)C1=O CHEMBL4070029 IC50 2.2 nM
COc1ncc(-c2ccc3ncnc(NCCN4CCOCC4)c3c2)cc1NS(C)(=O)=O CHEMBL4439145 IC50 2.2 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(c4cccnc4)C(=O)C3)cc2n1 CHEMBL4799262 IC50 2.2 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(C4CCC5(CC4)OCCO5)CC3=O)cc2n1 CHEMBL4762501 IC50 2.2 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(S(C)(=O)=O)CC3=O)cc2n1 CHEMBL4783917 IC50 2.2 nM
COc1cc(-c2cc3c(N[C@H]4CCN(C(=O)C5CCC5)C4)ncnc3s2)cnc1OC CHEMBL5192588 IC50 2.2 nM
Cc1nc(-c2cn3c(n2)-c2cc(-c4ccnn4C4CCCN(C5COC5)C4)c(F)cc2OCC3)n(C(C)C)n1 CHEMBL3704729 IC50 2.21 nM
Cc1c(F)ccc2cc([C@H](C)Nc3ncnc(N)c3C#N)c(-c3ccccc3)c(=O)n12 CHEMBL4783353 IC50 2.28 nM
Cc1nc(-c2cn3c(n2)-c2cc(C(C)N4CCN(C(C)(C)C)CC4)c(F)cc2OCC3)n(C(C)C)n1 CHEMBL3704713 IC50 2.29 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(C4COC4)CC3(C)C)cc2n1 CHEMBL2165502 IC50 2.3 nM
CC(C)(C(N)=O)N1CCN(Cc2cc3nc(-c4ccnc5[nH]ccc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL2165513 IC50 2.3 nM
Cn1c(CN2CCC(C(C)(C)O)CC2)nc2c(N3CCOCC3)nc(-c3cccc4[nH]ncc34)nc21 CHEMBL2414239 Ki(app) 2.3 nM
CC(=O)N1CCN(c2cc(-c3cc(Cl)c4c(N)ncnn34)ccc2S(C)(=O)=O)C(=O)C1(C)C CHEMBL4084604 IC50 2.3 nM
N#Cc1c(N)nc(N)nc1N1CC2(CC2)C[C@H]1c1nc2cccc(Cl)c2c(=O)n1Cc1ccc(C(=O)NO)s1 CHEMBL5218472 IC50 2.3 nM
Cc1nc(-c2cn3c(n2)-c2cc([C@H](C)N4CCN(C(C)C)CC4)c(F)cc2OCC3)n(C(C)C)n1 CHEMBL3704722 IC50 2.32 nM
CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cnc(N)nc4)nc(N4CCOCC4)c3s2)CC1 CHEMBL1083192 IC50 2.4 nM
Cc1c(CN2CCN(C(=O)[C@H](C)N)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1922091 IC50 2.4 nM
Cc1sc2ccccc2c1-c1nc(N2CCOCC2)c2sc(CN3CCC(N(C)C)CC3)cc2n1 CHEMBL2165492 IC50 2.4 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2c(-c2ccccn2)c1-c1ccccn1 CHEMBL3403678 IC50 2.4 nM
N#Cc1c(N)nc(N)nc1N[C@H](c1nc2c(Cl)ccc(Cl)c2c(=O)n1-c1cnc(N)cn1)C1CC1 CHEMBL3928265 IC50 2.4 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4ccnn4C4CCOCC4)c4c(N)ncnn34)c2)CC1 CHEMBL4071580 IC50 2.4 nM
CC(=O)N1CCN(c2cccc(-c3cc(C(F)(F)F)c4c(N)ncnn34)c2)C(=O)C1(C)C CHEMBL4064543 IC50 2.4 nM
CC(=O)N1C[C@H](C)N(c2cc(-c3cc(Cl)c4c(N)ncnn34)ccc2C#N)C(=O)C1(C)C CHEMBL4068408 IC50 2.4 nM
C[C@@H]1CN(c2cc(-c3cc(C(F)(F)F)c4c(N)ncnn34)ccc2C#N)C(=O)C(C)(C)O1 CHEMBL4067250 IC50 2.4 nM
Cc1nc(-c2cn3c(n2)-c2cc([C@H](C)N4CCN(C(C)(C)C)CC4)c(F)cc2OCC3)n(C(C)C)n1 CHEMBL3704696 Ki(app) 2.4 nM
COc1c([C@H](C)n2nc(C)c3c(N)ncnc32)cc(Cl)c(C)c1C1CNC(=O)C1 CHEMBL4443149 IC50 2.4 nM
CC(C)n1nc(CO)nc1-c1cn2c(n1)-c1ccc(-c3ccnn3C3CCN(C)CC3)cc1OCC2 CHEMBL3704691 IC50 2.42 nM
CC(C)n1ncnc1-c1cn2c(n1)-c1cc(CN3CCN(C(C)(C)C)CC3)ccc1OCC2 CHEMBL3704659 IC50 2.46 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2c([S+]([O-])CCO)c1-c1ccccc1 CHEMBL3403667 IC50 2.5 nM
COCCOCCOCC#Cc1cccc2nc(Cn3nc(-c4cc(O)cc(F)c4)c4c(N)ncnc43)n(Cc3ccccc3C(F)(F)F)c(=O)c12 CHEMBL3934989 IC50 2.5 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4ccnn4C4CC4)c4c(N)ncnn34)c2)CC1 CHEMBL4098611 IC50 2.5 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCCN(C(=O)C5CCNCC5)C4)c3c2)cc1C#N CHEMBL4563455 IC50 2.5 nM
CC[C@@H](Nc1ncnc2nc[nH]c12)c1nc2cccc(F)c2c(=O)n1-c1ccccc1 CHEMBL4095008 IC50 2.5 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(CC4CC4)C(=O)C3)cc2n1 CHEMBL4786126 IC50 2.5 nM
COCCNCc1cccc(Cc2c([C@H](C)Nc3ncnc(N)c3C#N)cc3scc(C)n3c2=O)c1 CHEMBL4080523 pIC50 2.512 nM
Cc1csc2cc([C@H](C)Nc3ncnc(N)c3C#N)c(Cc3cccc(CN4CCC4)c3)c(=O)n12 CHEMBL4096646 pIC50 2.512 nM
Cc1csc2cc([C@H](C)Nc3ncnc(N)c3C#N)c(-c3cccc(CCN(C)C)c3)c(=O)n12 CHEMBL4088952 pIC50 2.512 nM
Cc1csc2cc([C@H](C)Nc3ncnc(N)c3C#N)c(-c3cccc(CN4CCC(CN(C)CC(C)C)CC4)c3)c(=O)n12 CHEMBL4083582 pIC50 2.512 nM
Oc1cccc(-c2nc(N3CCOCC3)c3sc(CN4CCC(n5cnnc5C(F)(F)F)CC4)cc3n2)c1 CHEMBL4081413 pIC50 2.512 nM
FC(F)(F)c1nnc2n1[C@H]1CCN(Cc3cc4nc(-c5cccc6[nH]ncc56)nc(N5CCOCC5)c4s3)C[C@H]1CC2 CHEMBL4078972 pIC50 2.512 nM
COc1ncc(N2CCOCC2)cc1S(=O)(=O)Nc1ccnc(-c2ccc(CN3CCN(C(C)(C)C)CC3)cc2F)c1 CHEMBL4175571 pIC50 2.512 nM
Cc1nc(-c2cn3c(n2)-c2ccc(OC4CC(C)CN(C(C)C)C4)cc2OCC3)n(C(C)C)n1 CHEMBL3704666 IC50 2.56 nM
CC(C)(O)C1CCN(Cc2ccc3nc(-c4cnc(N)nc4)nc(N4CCOCC4)c3n2)CC1 CHEMBL2152771 IC50 2.6 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3ncc[nH]3)ccc1-2 CHEMBL2381270 IC50 2.6 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nn(-c2cccc(S(C)(=O)=O)c2)c2cc(F)ccc12 CHEMBL5201633 IC50 2.6 nM
CC(c1nn(-c2cccc(S(C)(=O)=O)c2)c2cc(Cl)ccc12)n1nc(-c2cnn(C)c2)c2c(N)ncnc21 CHEMBL5397684 IC50 2.6 nM
COc1ncc(-c2nn(C(C)c3nn(-c4cccnc4)c4cc(Cl)ccc34)c3ncnc(N)c23)cn1 CHEMBL5401724 IC50 2.6 nM
Cc1nc(-c2cn3c(n2)-c2cc([C@@H](C)N4CCN(C(C)(C)CO)CC4)ncc2OCC3)n(C(C)C)n1 CHEMBL3704737 IC50 2.63 nM
Cc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCC(N(C)C)CC3)cc2n1 CHEMBL2165498 IC50 2.7 nM
N#Cc1c(N)nc(N)nc1N[C@H](c1nc2cccc(Cl)c2c(=O)n1-c1cnc(N)cn1)C1CC1 CHEMBL3912814 IC50 2.7 nM
COc1ccc(-c2cc(C(F)(F)F)c3c(N)ncnn23)cc1N1CCN(C(C)=O)C(C)(C)C1=O CHEMBL4100099 IC50 2.7 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cc(NS(C)(=O)=O)cc6[nH]ccc56)c34)n(-c3ccccc3)c(=O)c12 CHEMBL4167561 IC50 2.7 nM
COc1ncc(-c2cc3c(C)nc(N)nc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4226082 IC50 2.7 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCN(C(=O)C5CCOCC5)C4)c3c2)cc1C#N CHEMBL4227381 IC50 2.7 nM
Cc1c(CN2CCN(C(=O)c3cc4cccc(C(N)=O)c4o3)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL4865059 IC50 2.7 nM
Cc1nc(-c2cn3c(n2)-c2cc(C(=O)N4CCN(C(C)(C)C)CC4)c(F)cc2OCC3)n(C(C)C)n1 CHEMBL3704677 IC50 2.73 nM
Cc1nc2ccccc2n1-c1nc(N2CCOCC2)c2oc(CN3CCN(C(C)(C)C(N)=O)CC3)cc2n1 CHEMBL2216882 IC50 2.74 nM
CC(C)(O)C1CCN(Cc2ccc3nc(-c4cccc5[nH]ccc45)nc(N4CCOCC4)c3n2)CC1 CHEMBL2152769 IC50 2.8 nM
CC(Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2c(O)c1-c1ccccc1 CHEMBL3403666 IC50 2.8 nM
COc1ncc(-c2ccc3nccc(-c4ccc(Cn5cncn5)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3968925 IC50 2.8 nM
Cc1nc(-c2cn3c(n2)-c2cc([C@@H](C)N4CCN(C(C)(C)C)CC4)ncc2OCC3)n(C(C)C)n1 CHEMBL3704703 Ki(app) 2.8 nM
c1cnc2ccc(Nc3nc(NC4CC4)c4nc[nH]c4n3)cc2c1 CHEMBL4545915 IC50 2.8 nM
COc1c([C@H](C)Nc2ncnc3[nH]cnc23)cc(Cl)c(C)c1-c1cnn(C)c1 CHEMBL4513857 IC50 2.8 nM
Cc1c(-c2ccccn2)nc2cc(F)cc(F)c2c1Nc1cc(N2CCOCC2)cnc1-c1ccc(O)cc1 CHEMBL2216890 Ki 2.85 nM
Cc1nc(-c2cn3c(n2)-c2ccc(OC4(CC5CC5)CNC4)cc2OCC3)n(C(C)C)n1 CHEMBL3704687 IC50 2.9 nM
COc1ccc(-c2ccc3ncnc(N[C@H]4CCN(C(=O)C5CCCCC5)C4)c3c2)cn1 CHEMBL4227461 IC50 2.9 nM
CNC(=O)c1c(-c2ccccn2)c([C@H](C)Nc2ncnc(N)c2C#N)nc2ccc(F)cc12 CHEMBL4470291 IC50 2.9 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(C4CCCC4)CC3=O)cc2n1 CHEMBL4753342 IC50 2.9 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(C(=O)C4CCCCC4)CC3=O)cc2n1 CHEMBL4797595 IC50 2.9 nM
O=C1NCc2c1cc(O[C@@H]1CCN(C(=O)C3CC3)C1)cc2-c1cncc(O)c1 CHEMBL4848004 IC50 2.9 nM
CC(=O)N1CCN(c2nc(N3CCOCC3)nc(-n3c(C(F)F)nc4ccccc43)n2)CC1 CHEMBL4125884 IC50 2.9 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(-c4ccccc4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4872806 IC50 2.91 nM
CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL521851 IC50 3.0 nM
Cc1ccccc1-n1c(Cn2nc(-c3cccc(O)c3)c3c(N)ncnc32)nc2cccc(C)c2c1=O CHEMBL1241767 IC50 3.0 nM
Cc1nc(N)nc(-n2c(Nc3cccc(O)c3)nc3ccccc32)n1 CHEMBL1762788 IC50 3.0 nM
Cc1c(Cn2ccn3c(=O)cc(N4CCO[C@H](C)C4)nc23)cccc1C(F)(F)F CHEMBL1957870 IC50 3.0 nM
Cc1cc(NC(=O)CCNC(=O)Nc2nc(C)c(-c3ccc(S(C)(=O)=O)c(F)c3)s2)no1 CHEMBL2071340 Ki 3.0 nM
Cc1c(Cl)cccc1Cn1c(N)nc(=O)c2sc(N3CCOCC3)nc21 CHEMBL2089120 IC50 3.0 nM
Cc1c(Cn2c(CO)nc(=O)c3sc(N4CCOCC4)nc32)cccc1C(F)(F)F CHEMBL2089112 IC50 3.0 nM
COc1ccc(Nc2ncc(CN3CCC(S(C)(=O)=O)C3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165004 Ki 3.0 nM
COc1ccc(Nc2ncc(CN3CCC(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165019 Ki 3.0 nM
COc1ccc(Nc2ncc(CN3CCN(C(=O)N(C)C)CC3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165016 Ki 3.0 nM
Cc1ncnc(-n2c(Nc3cccc(O)c3)nc3ccccc32)n1 CHEMBL2165051 Ki 3.0 nM
CC(C)(C(N)=O)N1CCN(Cc2cc3nc(-c4c(F)ccc5[nH]ccc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL2165504 IC50 3.0 nM
Cc1c(-c2ccccn2)nc2cc(F)ccc2c1N1CC(C)(C)c2ncc(-c3ccnc(N)n3)cc21 CHEMBL2171930 Ki 3.0 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3C[C@@H]4C[C@H]3CN4C3COC3)n(C)c2n1 CHEMBL2171941 IC50 3.0 nM
Cn1c(CN2CCC(C(C)(C)O)CC2)nc2c(N3CCOCC3)nc(-n3c(C4CC4)nc4ccccc43)nc21 CHEMBL2171950 IC50 3.0 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCC(C(C)(C)O)CC3)[nH]c2n1 CHEMBL2171943 IC50 3.0 nM
CCN(CC)C(=O)c1cccc(Nc2nc3ccc(-c4cncc(OC)c4)cc3s2)n1 CHEMBL2216850 Ki 3.0 nM
CCOC(=O)CCNC(=O)Nc1nc2c(s1)CN(c1cnc(Cl)c(OC)c1)CC2 CHEMBL2216848 Ki 3.0 nM
COc1cc2c(CC3CCCC(C)C3)c(C(=O)Nc3nn[nH]n3)sc2cc1C CHEMBL2216844 IC50 3.0 nM
FC(F)c1nc2ccccc2n1-c1nc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL586702 IC50 3.0 nM
Oc1cccc(-c2nc(N3CCOCC3)c3ncccc3n2)c1 CHEMBL3109116 IC50 3.0 nM
COc1ncc(N2CCc3ncnc(N[C@H]4CCN(C(=O)C5CCOCC5)C4)c3C2)cc1Cl CHEMBL3643428 IC50 3.0 nM
COc1ncc(N2CCc3ncnc(N[C@H]4CCN(C(=O)C5CCOC(C)(C)C5)C4)c3C2)cc1C(F)(F)F CHEMBL3643417 IC50 3.0 nM
COc1ncc(N2CCc3ncnc(N[C@H]4CCN(C(=O)C5CCOCC5)C4)c3C2)cc1C#N CHEMBL3643415 IC50 3.0 nM
Oc1cccc(-c2nc(N3CCOCC3)c3oc4ncccc4c3n2)c1 CHEMBL573339 IC50 3.0 nM
Nc1ncnc2c1c(-c1cc(O)c(F)c(F)c1)nn2C1Cc2ccccc2C1 CHEMBL3907591 IC50 3.0 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nn2ccc(C(F)(F)F)c2c(=O)n1-c1ccccc1 CHEMBL3980944 IC50 3.0 nM
CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1cncc(F)c1 CHEMBL3980395 IC50 3.0 nM
Cc1c(F)cncc1-n1c([C@@H](Nc2nc(N)nc(N)c2C#N)C2CC2)nc2c(F)ccc(Cl)c2c1=O CHEMBL3923554 IC50 3.0 nM
Cc1c(F)cncc1-n1c([C@@H](Nc2nc(N)nc(N)c2C#N)C2CC2)nc2cccc(Cl)c2c1=O CHEMBL3918604 IC50 3.0 nM
C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2cccc(Cl)c2c(=O)n1-c1ccc(N)nc1 CHEMBL3970845 IC50 3.0 nM
Nc1ncnc2c1c(-c1ccc(O)cc1)nn2Cc1nc2cccc(C#CCCCC(=O)N3CCCC3)c2c(=O)n1Cc1ccccc1Cl CHEMBL3950328 IC50 3.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3-c3ccc4cc[nH]c4c3)n(-c3ccccc3)c(=O)c12 CHEMBL3928013 IC50 3.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3C(=O)Nc3cccc(O)c3)n(-c3ccccc3)c(=O)c12 CHEMBL3975942 IC50 3.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(Cc5cccc(O)c5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3979863 IC50 3.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3C(=O)Nc3cc(C(N)=O)ccc3O)n(-c3ccccc3)c(=O)c12 CHEMBL3936888 IC50 3.0 nM
Cc1ccn2nc(CNc3ncnc(N)c3-c3cncc(C(F)F)c3)n(-c3ccccc3)c(=O)c12 CHEMBL3955921 IC50 3.0 nM
COc1ccc(S(=O)(=O)n2ccc3ccc(-c4c(N)ncnc4N[C@@H](C)c4nn5ccc(C)c5c(=O)n4-c4ccccc4)cc32)cc1 CHEMBL3896227 IC50 3.0 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4ccnn4CC(F)(F)F)c4c(N)ncnn34)c2)C(=O)C1(C)C CHEMBL4059848 IC50 3.0 nM
CC(=O)N1CCN(c2cccc(-c3cc(Cl)c4c(N)ncnn34)c2)C(=O)C1(C)C CHEMBL4086128 IC50 3.0 nM
COCCOCCNC(=O)CCCC#Cc1cccc2nc(Cn3nc(-c4cccc(O)c4)c4c(N)ncnc43)n(Cc3ccccc3Cl)c(=O)c12 CHEMBL4075540 IC50 3.0 nM
Cc1nc(NC(=O)[C@@H](C)N)sc1-c1cncc(NS(=O)(=O)c2ccccc2)c1 CHEMBL4169244 IC50 3.0 nM
COc1ccc(-c2ccc3ncnc(N[C@H]4CCN(C(=O)c5ccccc5)C4)c3c2)cn1 CHEMBL4225346 IC50 3.0 nM
COc1ncc(N2CCOc3cnc(O[C@H]4CCN(C(=O)C5CCS(=O)(=O)CC5)C4)cc32)cc1C CHEMBL4442510 IC50 3.0 nM
O=c1c2c(Cl)ccn2nc([C@@H]2CCCN2c2ncnc3[nH]cnc23)n1-c1cccc(F)c1 CHEMBL4574883 IC50 3.0 nM
CC(=O)c1c[nH]c2ncnc(N3CCC[C@H]3c3nn4ccc(Cl)c4c(=O)n3-c3cccc(F)c3)c12 CHEMBL4522342 IC50 3.0 nM
N#Cc1cnc(N)nc1N1CCC[C@H]1c1nn2ccc(Cl)c2c(=O)n1-c1ccccc1 CHEMBL4549473 IC50 3.0 nM
COc1ccc(-c2ccc3ncnc(O[C@H]4CCCN(C(=O)C5CC5)C4)c3c2)cn1 CHEMBL4461031 IC50 3.0 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(CNc3ncc(C(=O)NO)cn3)c2c(=O)n1-c1ccccc1 CHEMBL4583074 IC50 3.0 nM
CN(C)c1cccc(-c2cc(-c3ccnn3C3CCCCC3)c3c(N)ncnn23)c1 CHEMBL4551707 IC50 3.0 nM
CN(C)Cc1cccc(-c2cc(-c3ccnn3C3CCOCC3)c3c(N)ncnn23)c1 CHEMBL4460644 IC50 3.0 nM
Nc1ncnn2c(-c3cccc(CN4CCOCC4)c3)cc(-c3ccnn3C3CCCCC3)c12 CHEMBL4593143 IC50 3.0 nM
CC(=O)N1CCN(C(=O)c2cccc(-c3ncnc4ccc(-c5cnc6ccccc6c5)cc34)c2)CC1 CHEMBL4469006 IC50 3.0 nM
COc1cncc(-n2c([C@H](C)Nc3nc(N)nc(N)c3C#N)nc3cccc(Cl)c3c2=O)c1 CHEMBL3919440 EC50 3.0 nM
C=C1C[C@@H](c2nc3cccc(Cl)c3c(=O)n2-c2ccccc2)N(c2ncnc(N)c2C#N)C1 CHEMBL5195280 IC50 3.0 nM
C[C@H]1CC[C@@H](c2nc3cccc(Cl)c3c(=O)n2-c2cccc(F)c2)N1c1ncnc(N)c1C#N CHEMBL5206949 IC50 3.0 nM
CC1(C)OCCn2c1nc1c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL3813842 IC50 3.0 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-n4ccnc4C4CCCN(C(C)C)C4)cc2OCC3)n(C(C)C)n1 CHEMBL3704740 IC50 3.09 nM
CC(C)(C(N)=O)N1CCN(Cc2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL2165503 IC50 3.1 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(C(=O)N3CCC(C(C)(C)O)CC3)n(C)c2n1 CHEMBL2414296 Ki(app) 3.1 nM
COCc1c(-c2ccccn2)c([C@H](C)Nc2ncnc(N)c2C#N)nc2ccc(F)cc12 CHEMBL3400185 IC50 3.1 nM
O=S(=O)(Nc1cc(-c2cc3c(-c4ccncc4)ncnc3s2)cnc1Cl)c1ccc(F)cc1F CHEMBL3577925 IC50 3.1 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCN(C(=O)C5CCOCC5)C4)c3c2)cc1[N+](=O)[O-] CHEMBL4228571 IC50 3.1 nM
COc1ccc(-c2nn(C(C)c3nn(-c4cccc(S(C)(=O)=O)c4)c4cc(Cl)ccc34)c3ncnc(N)c23)cc1OC CHEMBL5433176 IC50 3.1 nM
Cc1nc(-c2cn3c(n2)-c2cc(C(C)N4CCN(C)CC4)c(F)cc2OCC3)n(C(C)C)n1 CHEMBL3704743 IC50 3.13 nM
Cc1csc2cc([C@H](C)Nc3ncnc(N)c3C#N)c(-c3cccc(CN(C)CCCN(C)Cc4ccc(Cl)cc4)c3)c(=O)n12 CHEMBL4102634 pIC50 3.162 nM
Cc1nnc2n1[C@H]1CCN(Cc3cc4nc(-c5cccc6[nH]ncc56)nc(N5CCOCC5)c4s3)C[C@H]1CC2 CHEMBL4100380 pIC50 3.162 nM
COCCS(=O)(=O)Nc1cc(-c2cc3c(c(OC[C@@H](C)N4CCC(C(C)(C)O)CC4)c2)COC3)cnc1OC CHEMBL4449047 pIC50 3.162 nM
COCCS(=O)(=O)Nc1cc(-c2cc3c(c(O[C@@H](C)CN4CCC(C(C)(C)O)CC4)c2)COC3)cnc1OC CHEMBL4447804 pIC50 3.162 nM
COc1ncc(-c2cc3c(c(OC[C@H]4CN(C5COC5)CCO4)c2)COC3)cc1NS(C)(=O)=O CHEMBL4436797 pIC50 3.162 nM
COc1ncc(N2CCOCC2)cc1S(=O)(=O)Nc1ccnc(-c2ccc(CN3CCN(C(C)C)CC3)c(F)c2)c1 CHEMBL4173087 pIC50 3.162 nM
COc1ncc(N2CCOCC2)cc1S(=O)(=O)Nc1ccnc(-c2ccc(CN3CCN(C(C)C)CC3)c(F)c2F)c1 CHEMBL4170075 pIC50 3.162 nM
COc1ncc(N2CCOCC2)cc1S(=O)(=O)Nc1cncc(-c2ccc(CN3CCN(C(C)C)CC3)cc2F)c1 CHEMBL4878638 pIC50 3.162 nM
CC(=O)Nc1nc(C)c(-c2cc3c(c(S(=O)(=O)Nc4cccc(S(C)(=O)=O)c4)c2)C(=O)N([C@@H](C)C2CC2)C3)s1 CHEMBL5082486 pIC50 3.162 nM
CC(Cc1ccc(Cl)c(Cl)c1)n1c(=O)[nH]c2c(C(N)=O)nc(-c3cccc(O)c3)nc21 CHEMBL5410207 pKi 3.162 nM
CC(C)(C(N)=O)N1CCN(Cc2cc3nc(-c4cc(C#N)cc5[nH]ccc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL2165507 IC50 3.2 nM
Cc1ccc(S(=O)(=O)Nc2cc(-c3sc(NC(=O)[C@@H](N)C(C)C)nc3C)cnc2Cl)cc1 CHEMBL4164334 IC50 3.2 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCCN(C(=O)C(F)(F)F)C4)c3c2)cc1C#N CHEMBL4568130 IC50 3.2 nM
CCOC(=O)CN1CCC[C@H](Nc2ncnc3ccc(-c4cnc(OC)c(C#N)c4)cc23)C1 CHEMBL4515495 IC50 3.2 nM
CC(C)NC(=O)c1c(-c2ccccc2)c([C@H](C)Nc2ncnc(N)c2C#N)nc2ccc(F)cc12 CHEMBL4461539 IC50 3.2 nM
O=C1COc2ccc(-c3ccnc(Cl)c3NS(=O)(=O)c3ccc(F)cc3)cc2N1c1ccc(Cl)cc1 CHEMBL4760517 IC50 3.2 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(C(C)=O)CC3=O)cc2n1 CHEMBL4783142 IC50 3.2 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C3CCCN3)ccc1-2 CHEMBL2381267 IC50 3.3 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4nnc(C)s4)c4c(N)ncnn34)c2)C(=O)C1(C)C CHEMBL4076137 IC50 3.3 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4cnc(Cl)n4C)c4c(N)ncnn34)c2)C(=O)C1(C)C CHEMBL4091840 IC50 3.3 nM
Cc1c(CN2CCN(C(=O)[C@H](C)O)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1922094 Kd 3.3 nM
Cc1nc(NC(=O)[C@@H](N)C(C)C)sc1-c1cnc(Cl)c(NS(=O)(=O)c2ccccc2Cl)c1 CHEMBL4160624 IC50 3.3 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1c(-c2ccccc2)c(=O)n2cc(F)ccc2c1-c1ccc(F)cc1 CHEMBL4756563 IC50 3.3 nM
CC(=O)Nc1ccc(Nc2cnnc3ccc(-c4cnc(Cl)c(NS(=O)(=O)c5ccccc5)c4)cc23)cc1 CHEMBL4852849 IC50 3.3 nM
COc1cc(-c2cc3c(O[C@H]4CCN(C(=O)C5CCC5)C4)ncnc3s2)cnc1OC CHEMBL5203775 IC50 3.3 nM
Cc1nc(-c2cn3c(n2)-c2ccc(OC4(CN5CCN(C)CC5)CC4)cc2OCC3)n(C(C)C)n1 CHEMBL3704665 IC50 3.31 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C(C)C)c4CN4CCN(C)CC4)cc2OCC3)n(C(C)C)n1 CHEMBL3704681 IC50 3.34 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1cc2ccc(F)cn2c(=O)c1-c1cc(F)cc(F)c1 CHEMBL4752055 IC50 3.36 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1c(C2CC2)c(=O)n2cc(F)ccc2c1-c1ccc(F)cc1 CHEMBL4778687 IC50 3.39 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(CO)ccc1-2 CHEMBL2381261 IC50 3.4 nM
COc1ncc(-c2ccc3nccc(-c4ccc(CN(C)CCO)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3905146 IC50 3.4 nM
COc1ccc(-c2ccc3ncnc(N[C@H]4CCN(C(=O)C5CCOCC5)C4)c3c2)cn1 CHEMBL4229081 IC50 3.4 nM
Cc1csc2nc([C@H](C)Nc3ncnc4[nH]cnc34)c(-c3cccc(F)c3)c(=O)n12 CHEMBL2216863 IC50 3.4 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(c4cnn(C)c4)C(=O)C3)cc2n1 CHEMBL4761003 IC50 3.4 nM
C#Cc1ccc(-c2cc3c(c(-c4cnc(OC)c(NS(C)(=O)=O)c4)c2)CNC3=O)cn1 CHEMBL4867101 IC50 3.4 nM
CC(C)(O)C1CCN(Cc2ccc3nc(-c4c(F)ccc5[nH]ccc45)nc(N4CCOCC4)c3n2)CC1 CHEMBL2152768 IC50 3.43 nM
CC(C)(C(N)=O)N1CCN(Cc2cc3nc(-c4nccc5[nH]ccc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL2165511 IC50 3.5 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1ccccc1-2 CHEMBL2381253 IC50 3.5 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(F)ccc(Cl)c2c(=O)n1-c1cnc(N)cn1 CHEMBL3915208 IC50 3.5 nM
CC(=O)N1CCN(c2cc(-c3cc(C(F)(F)F)c4c(N)ncnn34)ccc2C(C)O)C(=O)C1(C)C CHEMBL4092344 IC50 3.5 nM
Nc1ncc(-c2nc(N3CCOCC3)nc(N3CCOCC3)n2)c(C(F)(F)F)n1 CHEMBL4102855 Kd 3.5 nM
CCCS(=O)(=O)N1CCN(Cc2cc3nc(-n4c(CC)nc5ccccc54)nc(N4CCOCC4)c3s2)C(=O)C1 CHEMBL4764973 IC50 3.5 nM
C[C@@H]1CN(c2cc(-c3cc4c(c(-c5cc(O)cc(F)c5)c3)CNC4=O)ccn2)C[C@H](C)O1 CHEMBL4856718 IC50 3.5 nM
COc1c([C@H](C)Nc2ncnc3[nH]cnc23)cc(Cl)c(C)c1-c1ccc(S(C)(=O)=O)cc1 CHEMBL4470672 IC50 3.6 nM
CCNC(=O)c1c(-c2ccccn2)c([C@H](C)Nc2ncnc(N)c2C#N)nc2ccc(F)cc12 CHEMBL4572863 IC50 3.6 nM
Cc1cccc2cc([C@H](C)Nc3ncnc4[nH]cnc34)c(-c3ccccc3)c(=O)n12 CHEMBL4782337 IC50 3.6 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(C(=O)[C@H](C)O)CC3=O)cc2n1 CHEMBL4791430 IC50 3.6 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCCN(C(=O)C(C)N)C4)c3c2)cc1C#N CHEMBL4473306 IC50 3.7 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nn(-c2cccnc2)c2cc(F)ccc12 CHEMBL5190376 IC50 3.7 nM
CC(c1nn(-c2cccnc2)c2cc(Cl)ccc12)n1nc(-c2cccc(C#N)c2)c2c(N)ncnc21 CHEMBL5425681 IC50 3.7 nM
COc1ncc(-c2ccc3nccc(-c4ccc(CN(C)C)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL3963018 IC50 3.8 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nn2ccc(F)c2c(=O)n1-c1ccccc1 CHEMBL3924058 IC50 3.8 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(C4CCC(F)(F)CC4)CC3=O)cc2n1 CHEMBL4764632 IC50 3.8 nM
CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(C#CCCCC(=O)N3CCOCC3)c2c(=O)n1-c1ccccc1 CHEMBL4073929 IC50 3.82 nM
CC(C)n1nc(N)nc1-c1cn2c(n1)-c1ccc(-c3ccnn3C3CCN(C(C)(C)C)CC3)cc1OCC2 CHEMBL3704712 IC50 3.89 nM
CC(C)n1ncnc1-c1cc2c(s1)-c1ccc(C(N)=O)cc1OCC2 CHEMBL2322764 IC50 3.9 nM
C[C@@H]1CN(C(=O)C(C)(C)O)C[C@H](C)N1c1cccc(-c2cc(-c3ccnn3C3CCOCC3)c3c(N)ncnn23)c1 CHEMBL4091906 IC50 3.9 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCCN(C(=O)c5coc([N+](=O)[O-])c5)C4)c3c2)cc1C#N CHEMBL4457318 IC50 3.9 nM
COc1ncc(-c2cc3c(N4CCOCC4)ncnc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4745332 IC50 3.9 nM
Cc1nncn1C1CCN(Cc2cc3nc(-c4cccc(O)c4)nc(N4CCOCC4)c3s2)CC1 CHEMBL4068098 pIC50 3.981 nM
Cc1nncn1C1CCN(Cc2cc3nc(-c4cccc5[nH]ccc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL4105669 pIC50 3.981 nM
Cc1nnc2n1[C@H]1CCN(Cc3cc4nc(-c5cccc6[nH]ncc56)nc(N5CCOCC5)c4s3)C[C@@H]1CC2 CHEMBL4070417 pIC50 3.981 nM
COc1ncc(-c2cc3c(c(OCCN4CCC(C(C)(C)O)CC4)c2)CCOC3)cc1NS(C)(=O)=O CHEMBL4466265 pIC50 3.981 nM
COc1ncc2cc1NS(=O)(=O)CCN(C)Cc1ccc3c(c1)N2CCO3 CHEMBL4638471 pKd 3.981 nM
CNS(=O)(=O)c1cc(-c2sc(Nc3cccc(C(=O)NCCCN(C)C)n3)nc2C)cc2c1C(=O)N([C@@H](C)C1CC1)C2 CHEMBL5076518 pIC50 3.981 nM
NC(=O)c1nc(-c2cccc(O)c2)nc2c1[nH]c(=O)n2CCc1cccs1 CHEMBL5430685 pKi 3.981 nM
CC1(C)Cc2nc(N3CCOc4ccc(-c5cnn(Cc6ccccc6)c5)cc43)sc2C(=O)N1 CHEMBL522069 IC50 4.0 nM
CC1(C)Cc2nc(N3CCOc4ccc(-c5cnn(Cc6cccnc6)c5)cc43)sc2C(=O)N1 CHEMBL496541 IC50 4.0 nM
Cc1nn(CCCN)cc1-c1ccc2c(c1)N(c1nc3c(s1)C(=O)NC(C)(C)C3)CCO2 CHEMBL526463 IC50 4.0 nM
Cc1ccc(Nc2ccc3c(c2)N(c2nc4c(s2)C(=O)NC(C)(C)C4)CCO3)nn1 CHEMBL490428 IC50 4.0 nM
COc1ccc(-c2nn(C3CCC3)c3ncnc(N)c23)cc1OC CHEMBL1233881 IC50 4.0 nM
COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C(C3=O)[C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O CHEMBL428496 IC50 4.0 nM
Cc1c(Cn2c(C)nn3c(=O)cc(N4CCOC(C)C4)nc23)cccc1C(F)(F)F CHEMBL2018222 IC50 4.0 nM
Cc1cc(NC(=O)CCNC(=O)Nc2nc(C)c(-c3ccc(-n4cccn4)cc3)s2)no1 CHEMBL1986603 Ki 4.0 nM
CC(C)(O)C1CCN(Cc2cc3nc(-c4c(F)ccc5[nH]ccc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL2152776 IC50 4.0 nM
COc1ccc(Nc2ncc(CC3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165020 Ki 4.0 nM
COc1ccc(Nc2ncc(N3CCOCC3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165029 Ki 4.0 nM
Cn1c(CN2CCC(C(C)(C)O)CC2)nc2c(N3CCOCC3)nc(-n3c(C4CCCO4)nc4ccccc43)nc21 CHEMBL2171948 IC50 4.0 nM
C#Cc1cccc2nc(Cn3nc(-c4cccc(O)c4)c4c(N)ncnc43)n(Cc3cccc(OC)c3)c(=O)c12 CHEMBL2216862 IC50 4.0 nM
CC(C)(O)c1nc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc2n1CCO CHEMBL2418352 Ki 4.0 nM
CO[C@H]1C[C@@H](c2nc3cccc(Cl)c3c(=O)n2-c2ccccc2)N(c2ncnc(N)c2C#N)C1 CHEMBL3355022 IC50 4.0 nM
CC(Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2c(Cl)c1-c1ccccn1 CHEMBL3403673 IC50 4.0 nM
COc1ccc(-c2cc(CNc3ccc(S(=O)(=O)Nc4nnc(C)s4)cc3)cc(C(=O)NCCC(C)C)c2)cn1 CHEMBL3582351 IC50 4.0 nM
COc1ncc(N2CCc3ncnc(N[C@H]4CCN(C(=O)[C@H]5CC[C@@H](O)CC5)C4)c3C2)cc1C(F)(F)F CHEMBL3643421 IC50 4.0 nM
COc1ncc(N2CCc3ncnc(N[C@H]4CCN(C(=O)[C@H]5CC[C@@H](OC)CC5)C4)c3C2)cc1C(F)(F)F CHEMBL3643419 IC50 4.0 nM
COc1ncc(N2CCc3ncnc(N[C@H]4CCN(C(=O)[C@H]5CC[C@H](OC)CC5)C4)c3C2)cc1C(F)(F)F CHEMBL3643420 IC50 4.0 nM
COc1ncc(N2CCc3ncnc(O[C@H]4CCN(C(=O)c5oc(C)nc5C)C4)c3C2)cc1C#N CHEMBL3643375 IC50 4.0 nM
COc1ncc(N2CCc3ncnc(N[C@H]4CCN(C(=O)c5cnco5)C4)c3C2)cc1C(F)(F)F CHEMBL3643418 IC50 4.0 nM
Nc1ncnc2c1c(-c1cc(O)cc(Cl)c1)nn2C1Cc2ccccc2C1 CHEMBL3914552 IC50 4.0 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C(C)C)c4CN4CCN(C(C)(C)C)CC4)cc2OCC3)n(C(C)C)n1 CHEMBL3704680 IC50 4.0 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1cncc(C(F)F)c1 CHEMBL3943844 IC50 4.0 nM
Cc1cncc(-n2c([C@@H](Nc3nc(N)nc(N)c3C#N)C3CC3)nc3cccc(Cl)c3c2=O)c1 CHEMBL3971257 IC50 4.0 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2ccc(F)c(Cl)c2c(=O)n1-c1cccnc1 CHEMBL3954776 IC50 4.0 nM
Cc1ccncc1-n1c([C@H](C)Nc2nc(N)nc(N)c2C#N)nc2ccc(F)c(Cl)c2c1=O CHEMBL3909179 IC50 4.0 nM
C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2cccc(Cl)c2c(=O)n1-c1cccnc1 CHEMBL3892884 IC50 4.0 nM
Cc1c(F)cncc1-n1c([C@@H](C)Nc2nc(N)nc(N)c2C#N)nc2cccc(Cl)c2c1=O CHEMBL4113405 IC50 4.0 nM
Cc1ccn2nc([C@H](C)Nc3ncncc3-c3cc(O)cc(F)c3)n(-c3ccccc3)c(=O)c12 CHEMBL3956509 IC50 4.0 nM
CC(C)N1CCN(C(=O)CCCC#Cc2ccn3nc([C@H](C)Nc4ncnc(N)c4C#N)n(-c4ccccc4)c(=O)c23)CC1 CHEMBL3982507 IC50 4.0 nM
COc1cc(-c2c(N)ncnc2N[C@@H](C)c2nn3ccc(C)c3c(=O)n2-c2ccccc2)cc(C(F)(F)F)n1 CHEMBL3898084 IC50 4.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5ccn(Cc6ccccc6O)n5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3914025 IC50 4.0 nM
COc1ncc(N2CCc3ncnc(N[C@H]4CCN(C(=O)C5CCOCC5)C4)c3C2)cc1C(F)(F)F CHEMBL3643414 IC50 4.0 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(NCc3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1 CHEMBL4460447 IC50 4.0 nM
Cc1nc(N)nc(N[C@@H](C)c2nc3cccc(NCc4ccc(C(=O)NO)cc4)c3c(=O)n2-c2ccccc2)c1C#N CHEMBL4526673 IC50 4.0 nM
Nc1ncnn2c(-c3cccc(C4(N5CCOCC5)COC4)c3)cc(-c3ccnn3C3CCOCC3)c12 CHEMBL4574170 IC50 4.0 nM
CN1CCN(Cc2cccc(-c3cc(-c4ccnn4C4CCOCC4)c4c(N)ncnn34)c2)CC1 CHEMBL4469985 IC50 4.0 nM
O=C(CN1CCN(c2nc(N3CCOCC3)nc(-n3c(C(F)F)nc4ccccc43)n2)CC1)[C@H]1CCCN1 CHEMBL4469651 IC50 4.0 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1cncc(Cl)c1 CHEMBL3912748 EC50 4.0 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1cncc(C#N)c1 CHEMBL4800080 EC50 4.0 nM
COc1ncc(-c2cc(OCC3CCC3)cc3c2CNC3=O)cc1NS(C)(=O)=O CHEMBL4850175 IC50 4.0 nM
CCC(=O)N1CC[C@H](Nc2ncnc3c2nc(-c2cnc(C(C)(C)C)s2)n3C)C1 CHEMBL4852541 IC50 4.0 nM
CCn1c(-c2cnc(C)nc2)nc2c(N[C@H]3CCN(C(=O)C4CCC4)C3)ncnc21 CHEMBL4878995 IC50 4.0 nM
C[C@H]1CC[C@@H](c2nc3cccc(Cl)c3c(=O)n2-c2cccnc2)N1c1ncnc(N)c1C#N CHEMBL5199517 IC50 4.0 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nn(-c2cccnc2)c2ccccc12 CHEMBL5206559 IC50 4.0 nM
CC(c1nn(-c2cccnc2)c2cc(Cl)ccc12)n1nc(-c2ccsc2)c2c(N)ncnc21 CHEMBL5439011 IC50 4.0 nM
COc1ncc(-c2ccc3nncc(N4CCOCC4)c3c2)cc1NS(=O)(=O)c1ccccc1 CHEMBL4867375 IC50 4.08 nM
CN1C(=O)c2ccccc2N(C)c2nc(Nc3cccc(S(N)(=O)=O)c3)ncc21 CHEMBL3904942 IC50 4.1 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4cnn(C)c4)c4c(N)ncnn34)c2)C(=O)C1(C)C CHEMBL4105075 IC50 4.1 nM
[2H]C1([2H])OC(C)(C)C(=O)N(c2cc(-c3cc(C(F)(F)F)c4c(N)ncnn34)ccc2C#N)C1([2H])[2H] CHEMBL4069993 IC50 4.1 nM
COc1ccc(Cn2c(=O)n(C)c3cnc4ccc(-c5cnc(OC)c(NS(C)(=O)=O)c5)cc4c32)cc1 CHEMBL4550603 IC50 4.1 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(CC)C(=O)C3)cc2n1 CHEMBL4747763 IC50 4.1 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(S(C)(=O)=O)CC3)cc2n1 CHEMBL2165500 IC50 4.1 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4ncco4)c4c(N)ncnn34)c2)C(=O)C1(C)C CHEMBL4070164 IC50 4.2 nM
COc1ncc(-c2cc3c(C)nc(NC(C)=O)nc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F CHEMBL4228946 IC50 4.2 nM
Cc1nc(-c2cn3c(n2)-c2cc(C(C)N4CCN(CC(C)(C)O)CC4)c(C)cc2OCC3)n(C(C)C)n1 CHEMBL3704727 IC50 4.21 nM
O=C(NOCCOCCOCCOCCC(=O)N1CCN(c2cnc3ccc(-c4cnc(Cl)c(NS(=O)(=O)c5ccc(F)cc5)c4)cc3n2)CC1)c1ccc(F)c(F)c1Nc1ccc(I)cc1F CHEMBL5219124 IC50 4.22 nM
O=S(=O)(Nc1cc(-c2ccc3nccc(N4CCOCC4)c3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1738719 IC50 4.3 nM
Cc1c(CN2CCN(C(=O)CN)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1922090 IC50 4.3 nM
Cc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(C(C)(C)C(N)=O)CC3)cc2n1 CHEMBL2165499 IC50 4.3 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4ccnn4C4CCOCC4)c4c(N)ncnn34)c2)CC1c1ccccc1 CHEMBL4070480 IC50 4.3 nM
Cc1cccc(S(=O)(=O)Nc2cc(-c3sc(NC(=O)[C@@H](N)C(C)C)nc3C)cnc2Cl)c1 CHEMBL4174988 EC50 4.3 nM
CC(Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2c(C(=O)N2CCNCC2)c1-c1ccccn1 CHEMBL4442808 IC50 4.3 nM
NC(=O)c1cccc2cc(C(=O)N3CCN(Cc4cc5nc(-c6cnc(N)nc6)nc(N6CCOCC6)c5o4)CC3)oc12 CHEMBL4868231 IC50 4.3 nM
COc1ccc(-c2nn(C(C)c3nn(-c4cccc(S(C)(=O)=O)c4)c4cc(Cl)ccc34)c3ncnc(N)c23)cn1 CHEMBL5438322 IC50 4.3 nM
O=S(=O)(Nc1cc(-c2ccc3ncc(N4CCOCC4)nc3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914743 IC50 4.4 nM
Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3-c3ccc(O)c(F)c3)n(-c3ccccc3)c(=O)c12 CHEMBL4176794 IC50 4.4 nM
COc1ccc(-c2ccc3ncnc(N[C@H]4CCN(C(=O)C5CCCC5)C4)c3c2)cn1 CHEMBL4225061 IC50 4.4 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2n1-c1cc(F)cc(F)c1 CHEMBL4790186 IC50 4.4 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(S(=O)(=O)CC)CC3=O)cc2n1 CHEMBL4800610 IC50 4.4 nM
COc1ncc(-c2ccc3nncc(Cl)c3c2)cc1NS(=O)(=O)c1ccccc1 CHEMBL4846081 IC50 4.42 nM
O=S(=O)(Nc1cc(-c2ccc3nncc(Nc4ccccc4)c3c2)cnc1Cl)c1ccccc1 CHEMBL4867433 IC50 4.47 nM
COC(=O)N1C[C@@H](C)N(c2cccc(-c3cc(-c4ccnn4C4CCOCC4)c4c(N)ncnn34)c2)[C@@H](C)C1 CHEMBL4099634 IC50 4.5 nM
CC(=O)N1CCN(c2cc(C)cc(-c3cc(Cl)c4c(N)ncnn34)c2)C(=O)C1(C)C CHEMBL4096288 IC50 4.5 nM
COc1ccc(-c2ccc3ncnc(N[C@H]4CCN(C(=O)C5CC5)C4)c3c2)cn1 CHEMBL4228563 IC50 4.5 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(C(C)C)CC3=O)cc2n1 CHEMBL4759104 IC50 4.5 nM
COc1c(OCCCCCC(=O)NO)ccc2c1N=C(NC(=O)c1ccccc1)N1CCN=C21 CHEMBL5170300 IC50 4.5 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4ccnn4C4CCN(C(C)(C)C)CC4)cc2OCC3)n(C(C)C)n1 CHEMBL3704673 IC50 4.57 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nn2ccc(C#N)c2c(=O)n1-c1ccccc1 CHEMBL3910904 IC50 4.6 nM
COc1ccc(-c2ccc3ncnc(N[C@H]4CCN(C(=O)CC(C)(C)C)C4)c3c2)cn1 CHEMBL4225718 IC50 4.6 nM
CNC(=O)c1c(-c2ccccn2)c([C@H](C)Nc2ncnc(N)c2C#N)nc2cccc(F)c12 CHEMBL4443843 IC50 4.6 nM
Cc1nc2cnc3ccc(-c4cnc5[nH]ccc5c4)cc3c2n1-c1ccc(C(C)(C)C#N)nc1 CHEMBL5204586 IC50 4.6 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nn2cccc2c(=O)n1-c1ccccc1 CHEMBL3901527 IC50 4.7 nM
Cc1nc(N)ncc1-c1nc(N2CCOCC2)nc2c(CN3CCN(C(=O)[C@@H](C)O)CC3)csc12 CHEMBL4110117 IC50 4.7 nM
CN1CCN(c2cc(-c3cc(-c4ccnn4C4CCOCC4)c4c(N)ncnn34)ccn2)CC1 CHEMBL4099020 IC50 4.7 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCCN(CCO)C4)c3c2)cc1C#N CHEMBL4459721 IC50 4.7 nM
COc1cc(-c2cc3c(N[C@H]4CCN(C(=O)C5CC5)C4)ncnc3s2)cnc1OC CHEMBL5178373 IC50 4.7 nM
CC(=O)N1CCN(c2cc(-c3cc(Cl)c4c(N)ncnn34)ccc2C(C)O)C(=O)C1(C)C CHEMBL4102552 IC50 4.8 nM
CNCCNC(=O)c1c(-c2ccccn2)c([C@H](C)Nc2ncnc(N)c2C#N)nc2ccc(F)cc12 CHEMBL4525494 IC50 4.8 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(C4CCSCC4)CC3=O)cc2n1 CHEMBL4798399 IC50 4.8 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(S(=O)(=O)C4CC4)CC3)cc2n1 CHEMBL4784160 IC50 4.8 nM
COc1ncc(-c2cc(OC3CCC3)cc3c2CNC3=O)cc1NS(C)(=O)=O CHEMBL4849053 IC50 4.8 nM
CCN1CCN(C(C)c2cc3c(cc2F)OCCn2cc(-c4nc(C)nn4C(C)C)nc2-3)CC1 CHEMBL3704744 IC50 4.85 nM
CN(C)C1CCN(Cc2cc3nc(-c4cccc5[nH]ccc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL2216901 Ki 4.9 nM
CC(=O)Nc1nc(C)c(-c2ccc(Cl)c(S(=O)(=O)Nc3ccc(O)cc3)c2)s1 CHEMBL3787013 IC50 4.9 nM
CC1(C)OCCN(c2cc(-c3cc(C(F)(F)F)c4c(N)ncnn34)ccc2C#N)C1=O CHEMBL4093593 IC50 4.9 nM
CO/C=C/C(=O)c1cc2c3c(c(N)cc(NC(=O)C(C)C)c3n1)N=C2 CHEMBL4293970 Kd 4.9 nM
COc1ncc(-c2ccc3ncnc(O[C@H]4CCN(C(=O)C5CCOCC5)C4)c3c2)cc1C#N CHEMBL4557999 IC50 4.9 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(C)C(=O)C3)cc2n1 CHEMBL4792029 IC50 4.9 nM
Cc1c(CN2CCN(C(=O)C(C)(C)O)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1922095 IC50 5.0 nM
Cc1c(CN2CCN(S(C)(=O)=O)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1091978 IC50 5.0 nM
CC(O)c1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCC(C(C)(C)O)CC3)n(C)c2n1 CHEMBL2171951 IC50 5.0 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCC(C(C)(C)O)CC3)cc2n1 CHEMBL2165501 IC50 5.0 nM
CC1=CC(NC(=O)CCNC(=O)Nc2nc(C)c(-c3ccc(-n4cccn4)cc3)s2)=NC1 CHEMBL2216883 IC50 5.0 nM
Cc1cccc2nc([C@H](C)Nc3ncnc(N)c3C#N)c(-c3ccccc3)c(=O)n12 CHEMBL2216893 Ki 5.0 nM
N#Cc1c(N)ncnc1N1CSC[C@H]1c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 CHEMBL3355021 IC50 5.0 nM
COc1ncc(N2CCc3ncnc(O[C@H]4CCN(C(=O)c5cscn5)C4)c3C2)cc1C(F)(F)F CHEMBL3643401 IC50 5.0 nM
COc1ncc(N2CCc3ncnc(O[C@H]4CCN(C(=O)c5cnn(C)c5)C4)c3C2)cc1C(F)(F)F CHEMBL3643400 IC50 5.0 nM
CCC(=O)N1CC[C@H](Oc2ncnc3ccc(-c4cnc(OC)c(C#N)c4)cc23)C1 CHEMBL3960012 IC50 5.0 nM
Cn1c(=O)n(-c2ccc(C(C)(C)C#N)cc2)c2c3cc(-c4cnc5ccccc5c4)ccc3ncc21 CHEMBL1879463 IC50 5.0 nM
Cc1cccc2nc(C(C)Nc3ncnc4nc[nH]c34)n(-c3ccccc3)c(=O)c12 CHEMBL3675617 Ki 5.0 nM
N#Cc1c(N)nc(N)nc1N[C@@H](CC1CC1)c1nc2cccc(Cl)c2c(=O)n1-c1cccnc1 CHEMBL3914170 IC50 5.0 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1cncc(C2CC2)c1 CHEMBL3956715 IC50 5.0 nM
N#Cc1c(N)nc(N)nc1N[C@H](c1nc2ccc(F)c(Cl)c2c(=O)n1-c1cccnc1)C1CC1 CHEMBL3927128 IC50 5.0 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(Cl)cc(F)cc2c(=O)n1-c1ccc(N)nc1 CHEMBL3957788 IC50 5.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3-c3cnc(N)nc3)n(-c3ccccc3)c(=O)c12 CHEMBL3903544 IC50 5.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3-c3cc(O)cc(C(F)(F)F)c3)n(-c3ccccc3)c(=O)c12 CHEMBL3984124 IC50 5.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(C(=O)OCc5ccccc5)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3961902 IC50 5.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cc(C(F)(F)F)nn5C)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3984759 IC50 5.0 nM
C[C@H](Nc1ncnc2[nH]cc(-c3cc(NS(C)(=O)=O)cc4[nH]ccc34)c12)c1nn2cccc2c(=O)n1-c1ccccc1 CHEMBL3950624 IC50 5.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3-c3cc(O)c4ccn(S(=O)(=O)c5ccc(O)cc5F)c4c3)n(-c3ccccc3)c(=O)c12 CHEMBL3895749 IC50 5.0 nM
Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cc(NS(C)(=O)=O)cc6[nH]ncc56)c34)n(-c3ccccc3)c(=O)c12 CHEMBL3978674 IC50 5.0 nM
CCNc1ncc(-c2c(N)ncnc2N[C@@H](C)c2nn3ccc(C)c3c(=O)n2-c2ccccc2)cc1NS(=O)(=O)c1ccc(O)cc1 CHEMBL3919684 IC50 5.0 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4ccnn4C(C)C)c4c(N)ncnn34)c2)CC1 CHEMBL4093336 IC50 5.0 nM
Nc1ncnn2c(-c3cccc(N4CCNCC4)c3)cc(-c3ccnn3C3CCOCC3)c12 CHEMBL4098095 IC50 5.0 nM
CC(=O)N1CCN(c2cccc(-c3cc(C#N)c4c(N)ncnn34)c2)C(=O)C1(C)C CHEMBL4092240 IC50 5.0 nM
CC(=O)c1c[nH]c2ncnc(N3CCC[C@H]3c3nn4ccc(F)c4c(=O)n3-c3ccccc3)c12 CHEMBL4463472 IC50 5.0 nM
CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(CCc3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1 CHEMBL4555432 IC50 5.0 nM
CC[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(NCCCCC(=O)NO)c2c(=O)n1-c1ccccc1 CHEMBL4544187 IC50 5.0 nM
Nc1ncnn2c(-c3cccc(CN4CCCC4=O)c3)cc(-c3ccnn3C3CCOCC3)c12 CHEMBL4453817 IC50 5.0 nM
CC1(C)OC(=O)NC1c1cccc(-c2cc(-c3ccnn3C3CCOCC3)c3c(N)ncnn23)c1 CHEMBL4438127 IC50 5.0 nM
CN1C[C@H](O)C[C@@H]1c1cccc(-c2cc(-c3ccnn3C3CCOCC3)c3c(N)ncnn23)c1 CHEMBL4533914 IC50 5.0 nM
COc1ncc(-c2ccc3ncnc(-c4cccc(C(=O)N5CCN(C(C)=O)CC5)c4)c3c2)cc1C(F)(F)F CHEMBL4521888 IC50 5.0 nM
Cc1cc(F)cc(-c2c([C@H](C)Nc3nc(N)nc(N)c3C#N)cc3ccc(F)cn3c2=O)c1 CHEMBL4750109 IC50 5.0 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(Cl)cccc2c(=O)n1-c1cccnc1 CHEMBL3972344 EC50 5.0 nM
C[C@H]1CC[C@@H](c2nc3cccc(Cl)c3c(=O)n2-c2ccccc2)N1c1ncnc(N)c1C#N CHEMBL5178114 IC50 5.0 nM
Cc1csc2cc([C@H](C)Nc3ncnc(N)c3C#N)c(-c3cccc(CN(C)CCCN4C[C@@H](C)O[C@@H](C)C4)c3)c(=O)n12 CHEMBL4078365 pIC50 5.012 nM
COCCS(=O)(=O)Nc1cc(-c2cc3c(c(OC[C@H](C)N4CCC(C(C)(C)O)CC4)c2)COC3)cnc1OC CHEMBL4561242 pIC50 5.012 nM
CN(C1CCCN(Cc2cc3nc(-c4cnc(N)nc4)nc(N4CCOCC4)c3s2)C1)S(C)(=O)=O CHEMBL4456215 pIC50 5.012 nM
COc1ncc(-c2cc3c(c(NC(=O)c4cccc(C)n4)c2)COC3)cc1NS(C)(=O)=O CHEMBL4564931 pIC50 5.012 nM
COCCNC(=O)c1cccc(Nc2nc(C)c(-c3cc4c(c(S(C)(=O)=O)c3)C(=O)N([C@@H](C)C3CC3)C4)s2)n1 CHEMBL5088848 pIC50 5.012 nM
NC(=O)c1nc(-c2cccc(O)c2)nc2c1[nH]c(=O)n2C1CCN(Cc2ccccc2)C1 CHEMBL5425386 pKi 5.012 nM
O=C(c1cc([C@H]2CCCN2c2cccc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1)N1CCOCC1 CHEMBL4090811 IC50 5.1 nM
Cc1nc(N)ncc1-c1nc(N2CCOCC2)c2sc(C(C)(C)O)cc2n1 CHEMBL1085178 IC50 5.2 nM
CC(=O)N1CCN(c2cc(-c3cc(-c4ccnn4C4CCOCC4)c4c(N)ncnn34)ccn2)CC1 CHEMBL4080063 IC50 5.2 nM
COc1ccc(-c2ccc3ncnc(N[C@H]4CCN(C(=O)C5CCC5)C4)c3c2)cn1 CHEMBL4229019 IC50 5.2 nM
Cc1nc(NC(=O)[C@@H](N)C(C)C)sc1-c1cnc(Cl)c(NS(=O)(=O)c2ccccc2)c1 CHEMBL4171850 IC50 5.3 nM
Cc1c(Cl)cc(C(C)Nc2ncnc3[nH]cnc23)c(-c2cccc(F)c2)c1-c1cnn(C)c1 CHEMBL4570334 IC50 5.3 nM
C[C@@H](Nc1cnnc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccccc4)c3)cc12)c1ccccc1 CHEMBL4851945 IC50 5.46 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4ccnn4C4CCOCC4)c4c(N)ncnn34)c2)C(=O)C1 CHEMBL4081103 IC50 5.5 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4ccnn4CC(F)(F)F)c4c(N)ncnn34)c2)CC1 CHEMBL4101075 IC50 5.5 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4cscn4)c4c(N)ncnn34)c2)C(=O)C1(C)C CHEMBL4087001 IC50 5.5 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCN(C(=O)C5CC5)C4)c3c2)cc1C#N CHEMBL4226800 IC50 5.5 nM
COc1ccc(-c2ccc3ncnc(N[C@H]4CCN(C(=O)c5ccco5)C4)c3c2)cn1 CHEMBL4226448 IC50 5.5 nM
Cc1nc(-c2cn3c(n2)-c2cc([C@@H](C)N4CCN(C(C)(C)CO)CC4)c(F)cc2OCC3)n(C(C)C)n1 CHEMBL3704726 IC50 5.53 nM
CC(C)N1CCN(c2cnc3ccc(-c4cnc(Cl)c(NS(=O)(=O)c5ccc(F)cc5)c4)cc3n2)CC1 CHEMBL1914742 IC50 5.6 nM
Cc1c(CN2CCN(C(=O)CO)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1922093 IC50 5.6 nM
CN(C)C1CCN(Cc2cc3nc(-c4c[nH]c5ccccc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL2165495 IC50 5.6 nM
Cc1c([C@H](C)Nc2nc(N)nc(N)c2C#N)c(-c2ccccc2)c(=O)n2cc(F)ccc12 CHEMBL4791717 IC50 5.6 nM
Cc1nc(-c2cn3c(n2)-c2cc(C(=O)N4CCN(C(C)(C)CO)CC4)c(F)cc2OCC3)n(C(C)C)n1 CHEMBL3704684 IC50 5.63 nM
COCCOCCOCC#Cc1cccc2nc(Cn3nc(-c4cccc(O)c4)c4c(N)ncnc43)n(Cc3ccccc3F)c(=O)c12 CHEMBL3946385 IC50 5.7 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2n1-c1cncc(F)c1 CHEMBL4754382 fIC50 5.7 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(C4CCC(O)CC4)C(=O)C3)cc2n1 CHEMBL4791401 IC50 5.7 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nn(-c2ccncc2)c2cc(F)ccc12 CHEMBL5203122 IC50 5.7 nM
CCC(=O)N1CC[C@H](Nc2ncnc3sc(-c4cnc(OC)c(OC)c4)cc23)C1 CHEMBL5204818 IC50 5.7 nM
O=S(=O)(Nc1cc(-c2ccc3nccc(-c4cccnc4)c3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914726 IC50 5.9 nM
COc1ccc(NC(=O)c2c(C)oc3ncn(CC(C)C)c(=O)c23)cc1 CHEMBL2216872 IC50 5.9 nM
COc1ccc(Cn2c(=O)n(C)c3c4cc(-c5cnc(OC)c(NS(=O)(=O)C6CC6)c5)ccc4ncc32)cc1 CHEMBL4535169 IC50 5.9 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1c(-c2ccccc2)c(=O)n2cc(F)ccc2c1C1CC1 CHEMBL4751779 IC50 5.9 nM
CC1(C)Cc2nc(N3CCOc4ccc(Nc5ccc(-c6ccccc6)nn5)cc43)sc2C(=O)N1 CHEMBL496940 IC50 6.0 nM
CN(C)C1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)nc(N5CCOCC5)n4)cc3)cc2)CC1 CHEMBL592445 IC50 6.0 nM
CC(C)n1nc(-c2ccc3ncccc3c2)c2c(N)ncnc21 CHEMBL1233882 IC50 6.0 nM
COc1ccc(Nc2cc(-c3cccc(O)c3)nc(N3CCOCC3)n2)cn1 CHEMBL1290744 IC50 6.0 nM
O=S(=O)(Nc1cc(-c2ccc3nccc(N4CCN(Cc5ccncc5)CC4)c3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914724 IC50 6.0 nM
O=S(=O)(Nc1cc(-c2ccc3nccc(-c4ccncc4)c3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914727 IC50 6.0 nM
O=S(=O)(Nc1cc(-c2ccc3ncc(NCCN4CCOCC4)nc3c2)cnc1Cl)c1ccc(F)cc1 CHEMBL1914736 IC50 6.0 nM
COc1ccc(Nc2ncc(CN3CCN(S(=O)(=O)N(C)C)CC3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165018 Ki 6.0 nM
COC(=O)N1CCN(Cc2cnc(Nc3ccc(OC)nc3)c(-c3nc(C)nc(N)n3)c2)CC1 CHEMBL2165015 Ki 6.0 nM
COc1ccc(Nc2ncc(-c3cnn(C)c3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165033 Ki 6.0 nM
CC(C)(C(N)=O)N1CCN(Cc2cc3nc(-c4c(F)cc(F)c5[nH]ccc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL2165508 IC50 6.0 nM
Cc1c(-c2ccccn2)nc2cc(F)ccc2c1N1CC(C)(C)c2ncc(N3CCOCC3)cc21 CHEMBL2171929 IC50 6.0 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCN(S(C)(=O)=O)CC3)n(C)c2n1 CHEMBL2171938 IC50 6.0 nM
CN(C)c1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCC(C(C)(C)O)CC3)n(C)c2n1 CHEMBL2171936 IC50 6.0 nM
O=C1NC(=O)/C(=C/c2ccc3ncnc(N4CCC(C(F)(F)F)CC4)c3n2)S1 CHEMBL2216855 IC50 6.0 nM
C[C@H](Nc1ncnc2[nH]cnc12)c1nc2ccsc2c(=O)n1-c1ccccc1 CHEMBL2216885 IC50 6.0 nM
C[C@@H]1Cc2ccccc2N1C(=O)Cc1nc(N2CCOCC2)cc(=O)[nH]1 CHEMBL3112867 IC50 6.0 nM
COc1ncc(N2CCc3ncnc(O[C@H]4CCN(C(=O)c5oc(C)nc5C)C4)c3C2)cc1C(F)(F)F CHEMBL3643387 IC50 6.0 nM
COc1ncc(N2CCc3ncnc(N[C@H]4CCN(C(=O)C5CCN(C(C)=O)CC5)C4)c3C2)cc1C(F)(F)F CHEMBL3643416 IC50 6.0 nM
COc1ncc(N2CCc3ncnc(O[C@H]4CCN(C(=O)c5cn(C)cn5)C4)c3C2)cc1C(F)(F)F CHEMBL3643399 IC50 6.0 nM
CC(Nc1ncnc2nc[nH]c12)c1nc2ccsc2c(=O)n1-c1ccccc1 CHEMBL3675616 Ki 6.0 nM
Cc1ncc(F)cc1-n1c([C@H](C)Nc2nc(N)nc(N)c2C#N)nc2cccc(Cl)c2c1=O CHEMBL3919299 IC50 6.0 nM
C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2c(F)ccc(Cl)c2c(=O)n1-c1ccc(N)nc1 CHEMBL3920883 IC50 6.0 nM
N#Cc1c(N)ncnc1N[C@@H](CCOCc1ccccc1)c1nn2ccc(C#N)c2c(=O)n1-c1cc(F)cc(F)c1 CHEMBL3919111 IC50 6.0 nM
Cc1nc(NC(=O)CN)sc1-c1cnc(Cl)c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1 CHEMBL4447963 IC50 6.0 nM
CN(C)Cc1cccc(-c2cc(-c3ccnn3C3CCC(F)(F)CC3)c3c(N)ncnn23)c1 CHEMBL4471824 IC50 6.0 nM
Nc1ncnn2c(-c3cccc(C(=O)N4CCCC4)c3)cc(-c3ccnn3C3CCOCC3)c12 CHEMBL4434830 IC50 6.0 nM
CCC(=O)N1CC[C@H](Nc2ncnc3c2nc(-c2cnc(OC)c(C)c2)n3C)C1 CHEMBL4868988 IC50 6.0 nM
COCCOc1cnc(Nc2cnc(Cl)c(NS(C)(=O)=O)c2)c(-c2nc(C)nc(N)n2)c1 CHEMBL2206906 Ki 6.1 nM
N#Cc1c(N)nc(N)nc1N1CC2(CC2)C[C@H]1c1nc2cccc(Cl)c2c(=O)n1Cc1ccc(C(=O)NO)cc1 CHEMBL5218681 IC50 6.1 nM
Cc1nc(-c2cn3c(n2)-c2ccc(OC4(c5ccccc5)CN(C(C)C)C4)cc2OCC3)n(C(C)C)n1 CHEMBL3704678 IC50 6.2 nM
Cc1nc(NC(=O)[C@@H](N)C(C)C)sc1-c1cnc(Cl)c(NS(=O)(=O)c2c(F)cccc2F)c1 CHEMBL4169697 IC50 6.2 nM
CC(C)Oc1ccc(-c2nn([C@@H](C)c3oc4ccc(F)cc4c(=O)c3-c3cccc(F)c3)c3ncnc(N)c23)cc1F CHEMBL3948730 IC50 6.2 nM
COc1ccc(Cn2c(=O)n(C)c3c4cc(-c5cnc(OC)c(NS(=O)(=O)C(C)C)c5)ccc4ncc32)cc1 CHEMBL4440218 IC50 6.2 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(C4CCOCC4)CC3=O)cc2n1 CHEMBL4743060 IC50 6.2 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(CC(N)=O)CC3=O)cc2n1 CHEMBL4761019 IC50 6.2 nM
C[C@@H](c1oc2ccc(F)cc2c(=O)c1-c1cccc(F)c1)n1nc(-c2ccc(OC(F)F)c(F)c2)c2c(N)ncnc21 CHEMBL5170320 Kd 6.2 nM
CC(C)(O)C1CCN(Cc2ccc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3n2)CC1 CHEMBL2152770 IC50 6.3 nM
N#Cc1c(N)ncnc1N1CCC[C@H]1c1nc2cccc(F)c2c(=O)n1C1CCCC1 CHEMBL4591557 IC50 6.3 nM
COc1ccc(-c2nc(N3CCOCC3)c3sc(CN(C)c4ncc(C(=O)NO)cn4)cc3n2)cn1 CHEMBL3622533 IC50 6.3 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(CC4CC4)CC3=O)cc2n1 CHEMBL4755371 IC50 6.3 nM
CC(C)(C)NS(=O)(=O)c1cncc(-c2ccc3nc(NC(=O)NCCn4nnc(C5CC5)n4)nn3c2)c1 CHEMBL2057368 pIC50 6.31 nM
Oc1cc(N2CCOCC2)nc2c(Cc3cccc(Cl)c3Cl)c(C(F)(F)F)nn12 CHEMBL2322340 pIC50 6.31 nM
Cc1csc2cc([C@H](C)Nc3ncnc(N)c3C#N)c(-c3cccc(OCCN(C)C)c3)c(=O)n12 CHEMBL4099101 pIC50 6.31 nM
Cc1csc2cc([C@H](C)Nc3ncnc(N)c3C#N)c(-c3cccc(CN(C)CCCCN4C[C@@H](C)O[C@@H](C)C4)c3)c(=O)n12 CHEMBL4064748 pIC50 6.31 nM
COc1ncc(C2=CCOCC2)cc1NS(=O)(=O)c1cn(Cc2ccccc2)c(C)n1 CHEMBL4435246 pIC50 6.31 nM
CC(=O)N(C)C1CCN(Cc2cc3nc(-c4cccc5[nH]ccc45)nc(N4CCOCC4)c3s2)C1 CHEMBL4580111 pIC50 6.31 nM
CN(C1CCCN(Cc2cc3nc(-c4cccc5[nH]ccc45)nc(N4CCOCC4)c3s2)C1)S(C)(=O)=O CHEMBL4590897 pIC50 6.31 nM
COCC(=O)N(C)C1CCN(Cc2cc3nc(-c4cnc(N)nc4)nc(N4CCOCC4)c3s2)C1 CHEMBL4538734 pIC50 6.31 nM
CN(C1CCN(Cc2cc3nc(-c4cnc(N)nc4)nc(N4CCOCC4)c3s2)C1)S(C)(=O)=O CHEMBL4534127 pIC50 6.31 nM
CC(=O)N(C)C1CCN(Cc2cc3nc(-c4cnc(N)nc4)nc(N4CCOCC4)c3s2)CC1 CHEMBL4437468 pIC50 6.31 nM
COc1ncc(N2CCOCC2)cc1S(=O)(=O)Nc1ccnc(-c2ccc(CN3CCN(C(C)C)CC3)cc2F)c1 CHEMBL4167702 pIC50 6.31 nM
CC(=O)Nc1nc(C)c(-c2cc3c(c(S(=O)(=O)Nc4ccc(CN(C)C)cc4)c2)C(=O)N([C@@H](C)C2CC2)C3)s1 CHEMBL5077792 pIC50 6.31 nM
CNS(=O)(=O)c1cc(-c2sc(Nc3ccc(C(=O)NCCCN(C)C)cn3)nc2C)cc2c1C(=O)N([C@@H](C)C1CC1)C2 CHEMBL5091498 pIC50 6.31 nM
C[C@@H]1CN(C)C[C@H](C)N1c1cccc(-c2cc(-c3ccnn3C3CCOCC3)c3c(N)ncnn23)c1 CHEMBL4087086 IC50 6.4 nM
C[C@H](Nc1nc(N)nc2[nH]cnc12)c1nn2cccc2c(=O)n1-c1ccccc1 CHEMBL3985833 IC50 6.5 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnc(C)n4C4CCCN(C(C)C)C4)cc2OCC3)n(C(C)C)n1 CHEMBL3704708 IC50 6.51 nM
CS(=O)(=O)N1CCN(Cc2cc3nc(-c4ccc(N)nc4)nc(N4CCOCC4)c3s2)CC1 CHEMBL1083810 IC50 6.6 nM
N#Cc1c(N)ncnc1N1CCC[C@H]1c1nn2cccc2c(=O)n1-c1ccccc1 CHEMBL3976777 IC50 6.6 nM
CC(=O)N1CCN(c2cccc(-c3cc(-c4ccnn4C4COC4)c4c(N)ncnn34)c2)CC1 CHEMBL4072625 IC50 6.6 nM
COc1ncc(-c2cc(OC3CN(C(=O)C4CC4)C3)cc3c2CNC3=O)cc1NS(C)(=O)=O CHEMBL4874239 IC50 6.7 nM
CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(C#CCCCC(=O)N3CCCC3)c2c(=O)n1-c1ccccc1 CHEMBL4060396 IC50 6.73 nM
CCC(=O)Nc1nc(C)c(-c2cnc(Cl)c(NS(=O)(=O)c3ccccc3)c2)s1 CHEMBL4166220 IC50 6.8 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCN(C(C)=O)C4)c3c2)cc1NS(C)(=O)=O CHEMBL4449091 IC50 6.8 nM
CCOC(=O)CN1CCC[C@H](Nc2ncnc3ccc(-c4cnc(OC)c(C(F)(F)F)c4)cc23)C1 CHEMBL4457688 IC50 6.8 nM
Cc1c(CN2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL4858564 IC50 6.8 nM
N#Cc1c(N)nc(N)nc1N1C[C@@H](OC(=O)NCc2ccc(C(=O)NO)cc2)C[C@H]1c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1 CHEMBL5219509 IC50 6.8 nM
COc1ccc(-c2nn(C(C)c3nn(-c4cccnc4)c4cc(Cl)ccc34)c3ncnc(N)c23)cc1C CHEMBL5414087 IC50 6.8 nM
N#Cc1c(N)nc(N)nc1N1CC2(CC2)C[C@H]1c1nc2cccc(Cl)c2c(=O)n1Cc1cc(C(=O)NO)no1 CHEMBL5220243 IC50 6.9 nM
COc1ccc(Nc2ccc3c(c2)N(c2nc4c(s2)C(=O)NC(C)(C)C4)CCO3)nn1 CHEMBL522910 IC50 7.0 nM
Cc1ccccc1-n1c(Cn2nc(C#CCO)c3c(N)ncnc32)nc2cccc(C)c2c1=O CHEMBL1213116 IC50 7.0 nM
COc1ccc(Nc2ncc(-c3ccc(C)nc3)cc2-c2nc(C)nc(N)n2)cn1 CHEMBL2165032 Ki 7.0 nM
COc1cnc(Nc2ccc(OC)nc2)c(-c2nc(C)nc(N)n2)c1 CHEMBL2165025 Ki 7.0 nM
CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCC(C(C)(C)O)CC3)nc2n1 CHEMBL2171945 IC50 7.0 nM
Cc1cccc2nc(C(C)n3cnc4c(N)ncnc43)n(-c3ccccc3)c(=O)c12 CHEMBL2216871 Ki 7.0 nM
O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)N1CCc2c(-c3cccnc3)cccc21 CHEMBL3112857 IC50 7.0 nM
COc1ncc(N2CCc3ncnc(N[C@H]4CCN(C(=O)[C@H]5CC[C@H](O)CC5)C4)c3C2)cc1C(F)(F)F CHEMBL3643422 IC50 7.0 nM
C[C@@H]1CN(c2cc(=O)c3cc(C(=O)N(C)C)cc(CN(C)c4cc(F)cc(F)c4)c3o2)CCO1 CHEMBL3797698 IC50 7.0 nM
COc1ncc(-c2ccc3ncnc(-c4cccc(C(=O)N5CCN(C(C)=O)CC5)c4)c3c2)cc1C#N CHEMBL3977066 IC50 7.0 nM
C[C@H](Nc1ncnc2[nH]cnc12)c1nn2cccc2c(=O)n1-c1ccccc1 CHEMBL3957154 IC50 7.0 nM
C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2cccc(Cl)c2c(=O)n1-c1cncc(F)c1 CHEMBL3901860 IC50 7.0 nM
Cc1c(F)cncc1-n1c([C@H](C)Nc2nc(N)nc(N)c2C#N)nc2cccc(F)c2c1=O CHEMBL3909686 IC50 7.0 nM
N#Cc1c(N)nc(N)nc1N[C@@H](c1nc2c(F)ccc(Cl)c2c(=O)n1-c1cccnc1)C1CC1 CHEMBL4108664 IC50 7.0 nM
C#Cc1cccc2nc(Cn3nc(-c4cccc(O)c4)c4c(N)ncnc43)n(Cc3ccccc3Cl)c(=O)c12 CHEMBL3922023 IC50 7.0 nM
Cc1sc2c(-c3cnc(N)nc3)nc(N3CCOCC3)nc2c1CN1CCN(C(=O)CO)CC1 CHEMBL3950275 IC50 7.0 nM
C[C@H]1OC(C)(C)C(=O)N(c2cc(-c3cc(C(F)(F)F)c4c(N)ncnn34)ccc2C#N)[C@H]1C CHEMBL4091875 IC50 7.0 nM
C[C@@H]1CN(C(=O)c2cc(C3CCCN3c3cc(F)cc(F)c3)c3nc(N4CCOCC4)cnc3c2)C[C@H](C)N1 CHEMBL4125781 Kd 7.0 nM
CC(C)Nc1ccc2cnn(-c3cncc(-c4ccc(C(=O)O)cc4)n3)c2c1 CHEMBL4228654 IC50 7.0 nM
COc1ncc(N2CCc3ncnc(-c4ccnc(NC5CCN(C)CC5)c4)c3C2)cc1C CHEMBL4453747 IC50 7.0 nM
CC[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(NCc3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1 CHEMBL4455923 IC50 7.0 nM
CN(C)C(=O)c1cccc(-c2cc(-c3ccnn3C3CCCCC3)c3c(N)ncnn23)c1 CHEMBL4474149 IC50 7.0 nM
O=C(C[C@@H]1CCCN1)N1CCN(c2nc(N3CCOCC3)nc(-n3c(C(F)F)nc4ccccc43)n2)CC1 CHEMBL4555271 IC50 7.0 nM
C[C@H](Nc1nc(N)ncc1C#N)c1cc2ccc(F)cn2c(=O)c1-c1ccccc1 CHEMBL4742973 IC50 7.0 nM
Cc1c(CN2CCN(C(=O)[C@@H](C)O)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12 CHEMBL1921986 IC50 7.0 nM
Cc1nc(N)nc(N2CCC[C@H]2c2nc3cccc(C#CCCCC(=O)N4CCCC4)c3c(=O)n2-c2ccccc2)c1C#N CHEMBL4098370 IC50 7.1 nM
COc1ncc(-c2ccn3ncnc3c2)cc1NS(C)(=O)=O CHEMBL4517406 IC50 7.2 nM
Nc1nc2cc(-c3nn(CC4CCCC4)c4ncnc(N)c34)ccc2o1 CHEMBL3797933 IC50 7.3 nM
CC1(C)OCCN(c2cccc(-c3cc(Cl)c4c(N)ncnn34)c2)C1=O CHEMBL4067592 IC50 7.4 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCN(C(=O)C5CCOCC5)C4)c3c2)cc1NS(C)(=O)=O CHEMBL4542688 IC50 7.4 nM
Nc1cc(C(F)(F)F)c(-c2nc3c(c(N4CCOCC4)n2)CCN(C(=O)c2cc(Cc4n[nH]c(=O)c5ccccc45)ccc2F)C3)cn1 CHEMBL4470724 pIC50 7.413 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3ccc[nH]c3=O)ccc1-2 CHEMBL2381272 IC50 7.6 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1c(-c2ccccc2)c(=O)n2cc(F)ccc2c1-c1ccc(C(N)=O)cc1 CHEMBL4750646 IC50 7.6 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCCN(C(=O)C5CCOCC5)C4)c3c2)cc1C#N CHEMBL4561357 IC50 7.7 nM
C[C@H](Nc1ncnc2[nH]cnc12)c1nn(-c2cccnc2)c2cc(Cl)ccc12 CHEMBL5203575 IC50 7.7 nM
COc1ccc(-c2ccc3ncnc(N[C@H]4CCN(C(=O)C5CCOCC5)C4)c3c2)cc1C(N)=O CHEMBL4228715 IC50 7.8 nM
Cc1c(Cn2c(C)cn3c(=O)cc(N4CCOCC4)nc23)cccc1C(F)(F)F CHEMBL1957857 IC50 7.9 nM
C=CC(=O)N1CCN(Cc2cc3nc(-n4c(CC)nc5ccccc54)nc(N4CCOCC4)c3s2)C(=O)C1 CHEMBL4753343 IC50 7.9 nM
COc1ncc(-c2cc(-c3ncc(CN4CCN(C(C)C)CC4)o3)c3cn[nH]c3c2)cc1C(=O)Oc1ccc(F)cc1 CHEMBL5286800 IC50 7.9 nM
FC(F)(F)c1nnc2n1[C@H]1CCN(Cc3cc4nc(-c5cccc6[nH]ncc56)nc(N5CCOCC5)c4s3)C[C@@H]1CC2 CHEMBL4092258 pIC50 7.943 nM
COc1ncc(-c2cc(OCCN3CCC(C(C)(C)O)CC3)c3c(c2)[C@@H](C)OC3)cc1NS(C)(=O)=O CHEMBL4567736 pIC50 7.943 nM
CN(C1CCN(Cc2cc3nc(-c4cnc(N)nc4)nc(N4CCOCC4)c3s2)CC1)S(C)(=O)=O CHEMBL4453879 pIC50 7.943 nM
CC(=O)N(C)[C@@H]1CCN(Cc2cc3nc(-c4cnc(N)nc4)nc(N4CCOCC4)c3s2)C1 CHEMBL4462986 pIC50 7.943 nM
COc1ncc(-c2cc3c(c(NC(=O)c4csc(C)n4)c2)COC3)cc1NS(C)(=O)=O CHEMBL4522825 pIC50 7.943 nM
COc1ncc(N2CCOCC2)cc1S(=O)(=O)Nc1ccnc(-c2ccc(CN3C[C@@H](C)O[C@@H](C)C3)cc2F)c1 CHEMBL4175737 pIC50 7.943 nM
COc1ncc(N2CCOCC2)cc1S(=O)(=O)Nc1ccnc(-c2ccc(CN3CCN(C(C)(C)C)CC3)cc2)c1 CHEMBL4165185 pIC50 7.943 nM
Cc1nn(C)cc1-c1ccc2c(c1)N(c1nc3c(s1)C(=O)NC(C)(C)C3)CCO2 CHEMBL496542 IC50 8.0 nM
COCCNC(=O)c1nc2c(N3CCOCC3)nc(-c3cnc(N)nc3)cn2c1C CHEMBL2058172 Ki(app) 8.0 nM
Nc1ccc(-c2nc(N3CCOCC3)c3ncccc3n2)cn1 CHEMBL3109133 IC50 8.0 nM
N#Cc1c(N)ncnc1N1CCC[C@H]1c1nc2cccc(Cl)c2c(=O)n1C1CCOCC1 CHEMBL3355017 IC50 8.0 nM
COc1cc(N2CCc3ncnc(O[C@H]4CCN(C(=O)c5cnco5)C4)c3C2)cnc1OC CHEMBL3643370 IC50 8.0 nM
COc1cc(N2CCc3ncnc(O[C@H]4CCN(C(=O)c5cocn5)C4)c3C2)cnc1OC CHEMBL3643369 IC50 8.0 nM
CC(=O)Nc1cn2cc(-c3cnc(N)c(OC(C)C(F)(F)F)n3)ccc2n1 CHEMBL3753450 IC50 8.0 nM
Nc1ncnc2c1c(-c1cc(O)cc(F)c1)nn2C1Cc2ccccc2C1 CHEMBL3896635 IC50 8.0 nM
Nc1ncnc2c1c(-c1ccc(Br)c(O)c1)nn2C1Cc2ccccc2C1 CHEMBL3964073 IC50 8.0 nM
CC[C@H](Nc1ncnc2[nH]ccc12)c1nc2cccc(F)c2c(=O)n1-c1ccccc1 CHEMBL3927331 IC50 8.0 nM
C[C@H](Nc1ncnc2[nH]cc(F)c12)c1nc2cccc(F)c2c(=O)n1-c1cccc(OCC(F)(F)F)c1 CHEMBL3921325 IC50 8.0 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(F)ccc(F)c2c(=O)n1-c1cccnc1 CHEMBL3933760 IC50 8.0 nM
N#Cc1c(N)nc(N)nc1N[C@@H](CC1CC1)c1nc2c(F)ccc(Cl)c2c(=O)n1-c1cccnc1 CHEMBL3937412 IC50 8.0 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2ccc(F)c(Cl)c2c(=O)n1-c1ccc(N)nc1 CHEMBL3970492 IC50 8.0 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(C(O)CO)ccc1-2 CHEMBL2381262 IC50 8.1 nM
COc1ccc(-c2ccc3ncnc(N[C@H]4CCN(C(=O)OC(C)(C)C)C4)c3c2)cn1 CHEMBL4229265 IC50 8.1 nM
OCCNc1nc(N2CCOCC2)nc(-n2c(C(F)F)nc3ccccc32)n1 CHEMBL5094393 IC50 8.1 nM
COc1ncc(-c2cc(OCCCCCCC(=O)NO)c3ncnc(C)c3c2)cc1F CHEMBL4536105 IC50 8.1 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccccn2c(=O)c1-c1ccccc1 CHEMBL3680915 Ki 8.2 nM
CN(C)C(=O)c1cc([C@H]2CCCN2c2ccc(F)cc2)c2oc(N3CCOCC3)cc(=O)c2c1 CHEMBL4102511 IC50 8.2 nM
C[C@H]1CC[C@@H](c2nc3cccc(Cl)c3c(=O)n2-c2cccc(F)c2)N1c1ncnc2[nH]cnc12 CHEMBL5209029 IC50 8.21 nM
CC(Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2c(C#N)c1-c1ccccn1 CHEMBL3403677 IC50 8.3 nM
Cc1sc2c(-c3cnc(N)nc3)nc(N3CCOCC3)nc2c1CN1CCN(C(=O)[C@H](C)O)CC1 CHEMBL3891554 IC50 8.3 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2n1-c1cccc(F)c1 CHEMBL4762294 IC50 8.3 nM
C[C@H](Nc1ncnc(N)c1C#N)c1nc2cc(F)ccc2n1-c1cccc(S(C)(=O)=O)c1 CHEMBL4763925 IC50 8.3 nM
C[C@H]1OC(=O)N(c2nc(-c3cnc(N)nc3C(F)(F)F)cc(N3CCOCC3)n2)[C@H]1CO CHEMBL5203121 IC50 8.3 nM
CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(CNCCO)ccc1-2 CHEMBL2381264 IC50 8.4 nM
COc1ccc(-c2nn(Cc3nc4cccc(F)c4c(=O)n3-c3c(C)cccc3C)c3ncnc(N)c23)cc1OC CHEMBL4249477 IC50 8.4 nM
C[C@H](Nc1ncnc2[nH]cnc12)c1cc(Cl)c2cccnc2c1-c1cccc(F)c1 CHEMBL4440146 IC50 8.4 nM
CCN1CCC(Nc2cc(-c3ncnc4c3CN(c3cnc(OC)c(C)c3)CC4)ccn2)CC1 CHEMBL4528263 IC50 8.5 nM
COc1cc(-c2cc3c(N[C@H]4CCN(C(=O)C5CCCC5)C4)ncnc3s2)cnc1OC CHEMBL5178942 IC50 8.5 nM
Cc1nc(-c2cn3c(n2)-c2ccc(-c4ccnn4C4CCCN(Cc5ccccc5)C4)cc2OCC3)n(C(C)C)n1 CHEMBL3704668 IC50 8.53 nM
COc1ncc(-c2ccc3nncc(Nc4ccc(NC(C)=O)cc4)c3c2)cc1NS(=O)(=O)c1ccccc1 CHEMBL4859868 IC50 8.57 nM
Cc1ccc([N+](=O)[O-])cc1C(=O)N(C)/N=C/c1cnn2ccc(C#N)cc12 CHEMBL1928728 IC50 8.6 nM
O=C(c1cc([C@H]2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1)N1CCOCC1 CHEMBL4060768 IC50 8.6 nM
Cc1nc(NC(=O)[C@@H](N)CC(C)C)sc1-c1cnc(Cl)c(NS(=O)(=O)c2ccccc2)c1 CHEMBL4159763 IC50 8.6 nM
Cc1cccc(C)c1-n1c(Cn2nc(-c3ccc4[nH]ccc4c3)c3c(N)ncnc32)nc2cccc(F)c2c1=O CHEMBL4245221 IC50 8.6 nM
NOCCOCCOCCOCCN(CCO)c1nc(N2CCOCC2)nc(-n2c(C(F)F)nc3ccccc32)n1 CHEMBL5093356 IC50 8.6 nM
Cc1nc(-c2cn3c(n2)-c2ccc(OC4(CC(C)C)CN(C(C)C)C4)cc2OCC3)n(C(C)C)n1 CHEMBL3704700 IC50 8.67 nM
CC(Nc1ncnc(N)c1C#N)c1nc2ccc(F)cc2cc1-c1ccccn1 CHEMBL3403672 IC50 8.8 nM
Cc1nc(-c2cn3c(n2)-c2cc(C(C)N4CCN(C5COC5)CC4)c(C)cc2OCC3)n(C(C)C)n1 CHEMBL3704724 IC50 8.82 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCCN(C(=O)CCl)C4)c3c2)cc1C#N CHEMBL4562892 IC50 8.9 nM
COCCN(CCO)c1nc(N2CCOCC2)nc(-n2c(C(F)F)nc3ccccc32)n1 CHEMBL5078681 IC50 8.9 nM
COC[C@H](O)Cn1cc(-c2ccc3c(c2)N(c2nc4c(s2)C(=O)NC(C)(C)C4)CCO3)cn1 CHEMBL489602 IC50 9.0 nM
Cc1ccccc1-n1c(Cn2nc(-c3ccc(O)c(F)c3)c3c(N)ncnc32)nc2cccc(C)c2c1=O CHEMBL1213085 IC50 9.0 nM
Cc1nc(N)nc(-c2cccnc2Nc2cccc(O)c2)n1 CHEMBL2165052 Ki 9.0 nM
Fc1ccc2[nH]ccc2c1-c1nc(N2CCOCC2)c2sc(CN3CCN4CCOC[C@H]4C3)cc2n1 CHEMBL2165505 IC50 9.0 nM
Cc1c(-c2ccccn2)nc2cc(F)ccc2c1N1CC2(CCOCC2)c2ncc(N3CCOCC3)cc21 CHEMBL2171931 IC50 9.0 nM
COc1ncc(N2CCc3ncnc(O[C@H]4CCN(C(=O)c5oc(C)nc5C)C4)c3C2)cc1C CHEMBL3643358 IC50 9.0 nM
COc1ncc(N2CCc3ncnc(O[C@H]4CCN(C(=O)C5CCS(=O)(=O)CC5)C4)c3C2)cc1C(F)(F)F CHEMBL3643386 IC50 9.0 nM
O=C(C1CCOCC1)N1CC[C@H](Nc2ncnc3c2CN(c2cncc(C(F)(F)F)c2)CC3)C1 CHEMBL3643430 IC50 9.0 nM
COc1ncc(N2CCc3ncnc(O[C@H]4CCN(C(=O)C5CCCC5)C4)c3C2)cc1C#N CHEMBL3643357 IC50 9.0 nM
COc1ncc(N2CCc3ncnc(O[C@H]4CCN(C(=O)C5CCOCC5)C4)c3C2)c(OC)n1 CHEMBL3643350 IC50 9.0 nM
COc1ncc(N2CCc3ncnc(O[C@H]4CCN(C(=O)C5CCN(C(C)=O)CC5)C4)c3C2)cc1C(F)(F)F CHEMBL3643438 IC50 9.0 nM
COc1cc(N2CCc3ncnc(O[C@H]4CCN(C(=O)C5CCOC(C)(C)C5)C4)c3C2)cnc1OC CHEMBL3643372 IC50 9.0 nM
C[C@@H]1CN(c2cc(=O)c3cc(C(=O)N(C)C)cc(CN4CCOc5c(F)cc(F)cc54)c3o2)CCO1 CHEMBL3797812 IC50 9.0 nM
Nc1ncnc2c1c(-c1cc(O)cc(F)c1)nn2C1CCc2ccccc2C1 CHEMBL3905578 IC50 9.0 nM
COc1ccc(-c2ccc3ncnc(-c4cccc(C(=O)N5CCN(C(C)=O)CC5)c4)c3c2)cc1OC CHEMBL3944013 IC50 9.0 nM
CCC(=O)N1CC[C@H](Oc2ncnc3ccc(-c4ccc(OC)nc4)cc23)C1 CHEMBL3896413 IC50 9.0 nM
C[C@H](Nc1ncnc2[nH]ccc12)c1nc2cccc(F)c2c(=O)n1-c1ccc(OCC(F)(F)F)cc1 CHEMBL3965450 IC50 9.0 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(S(C)(=O)=O)c2c(=O)n1-c1cccnc1 CHEMBL3947434 IC50 9.0 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(C#N)c2c(=O)n1-c1cccnc1 CHEMBL3890147 IC50 9.0 nM
CC[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2cccc(Cl)c2c(=O)n1-c1ccc(N)nc1 CHEMBL3933314 IC50 9.0 nM
Nc1ccc(-n2c([C@@H](Nc3nc(N)nc(N)c3Cl)C3CC3)nc3cccc(Cl)c3c2=O)cn1 CHEMBL3948693 IC50 9.0 nM
CCC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2ccc(F)c(Cl)c2c(=O)n1-c1ccc(N)nc1 CHEMBL3898636 IC50 9.0 nM
CC[C@@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(F)ccc(Cl)c2c(=O)n1-c1cccnc1 CHEMBL4113570 IC50 9.0 nM
CC(=O)N1CCN(c2cccc(-c3cc(C)c4c(N)ncnn34)c2)C(=O)C1(C)C CHEMBL4102444 IC50 9.0 nM
COc1ncc(-c2ccc3ncnc(-c4cccc(C(=O)N5CCN(C)CC5)c4)c3c2)cc1C(F)(F)F CHEMBL4453497 IC50 9.0 nM
O=C([C@H]1CCCN1)N1CCN(c2nc(N3CCOCC3)nc(-n3c(C(F)F)nc4ccccc43)n2)CC1 CHEMBL3982304 IC50 9.0 nM
CCn1c(-c2cnc(C)nc2)nc2c(N[C@H]3CCN(C(=O)N4CC(OC)C4)C3)ncnc21 CHEMBL4878004 IC50 9.0 nM
CCn1c(=O)c(-c2cc[nH]n2)cc2c(C)nc(N)nc21 CHEMBL3545366 IC50 9.0 nM
C[C@H]1CC[C@@H](c2nc3cccc(Cl)c3c(=O)n2-c2cccc(F)c2)N1c1nc(N)nc2[nH]cnc12 CHEMBL5188211 IC50 9.0 nM
COCC(=O)N1CCC(Nc2cc(-c3ncnc4c3CN(c3cnc(OC)c(C)c3)CC4)ccn2)CC1 CHEMBL4530810 IC50 9.2 nM
CCN(/N=C/c1cnn2ccc(C#N)cc12)S(=O)(=O)c1cc([N+](=O)[O-])ccc1C CHEMBL1928555 IC50 9.3 nM
CC1(C)OCCN(c2cc(-c3cc(-c4ccnn4CC(F)(F)F)c4c(N)ncnn34)ccc2C#N)C1=O CHEMBL4071877 IC50 9.4 nM
COc1ncc(-c2ccc3ncnc(N[C@H]4CCCN(C(=O)C5CCN(C)CC5)C4)c3c2)cc1C#N CHEMBL4533939 IC50 9.4 nM
CNC(=O)c1ccc(-c2nn(C(C)c3nn(-c4cccnc4)c4cc(Cl)ccc34)c3ncnc(N)c23)cc1 CHEMBL5406648 IC50 9.4 nM
C[C@H](Nc1nc(N)nc(N)c1C#N)c1cc(=O)n2cc(F)ccc2c1-c1cc(F)cc(F)c1 CHEMBL4755417 IC50 9.42 nM
COc1ccc(Cn2c(=O)n(C)c3c4cc(-c5cnc6ccccc6c5)ccc4ncc32)cc1 CHEMBL4454741 IC50 9.5 nM
CNCCNC(=O)c1c(-c2ccccc2)c([C@H](C)Nc2ncnc(N)c2C#N)nc2ccc(F)cc12 CHEMBL4438514 IC50 9.5 nM
CC(=O)NCCNc1nc(N2CCOCC2)nc(-n2c(C(F)F)nc3ccccc32)n1 CHEMBL5086257 IC50 9.5 nM
C[C@@H]1CN(C2COC2)C[C@H](C)N1c1cccc(-c2cc(-c3ccnn3C3CCOCC3)c3c(N)ncnn23)c1 CHEMBL4072750 IC50 9.6 nM
COc1ncc(N2CCc3ncnc(-c4ccnc(NC5CCN(S(C)(=O)=O)CC5)c4)c3C2)cc1C CHEMBL4518787 IC50 9.6 nM
C=CC(=O)N(CCn1nc(-c2cc(O)c(Br)c(F)c2)c2c(N)ncnc21)Cc1ccc(Cl)cc1 CHEMBL5277058 IC50 9.7 nM
CN(C)C1CCN(Cc2cc3nc(-c4n[nH]c5ccccc45)nc(N4CCOCC4)c3s2)CC1 CHEMBL2165493 IC50 9.8 nM
CC1(C)OCCN(c2cccc(-c3cc(C(F)(F)F)c4c(N)ncnn34)c2)C1=O CHEMBL4061641 IC50 9.8 nM
C[C@H](Nc1ncnc2[nH]cnc12)c1cc2ccc(F)cn2c(=O)c1-c1ccccc1 CHEMBL4749877 IC50 9.8 nM
OCCN(CCO)c1nc(N2CCOCC2)nc(-n2c(C(F)F)nc3ccccc32)n1 CHEMBL5087654 IC50 9.9 nM