C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3105022 Ki 0.001 nM
C[C@H]1CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@@H]1O CHEMBL3105021 Ki 0.001 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4107029 Ki 0.001 nM
COc1ccc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c1F CHEMBL4111580 Ki 0.001 nM
CCOc1ccc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c1F CHEMBL4107575 Ki 0.001 nM
Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 CHEMBL3103868 Ki 0.002 nM
Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1N1CC[C@@H](O)[C@H](N)C1 CHEMBL3103869 Ki 0.002 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)ccc(I)c3F)sc2N)c1N1CC[C@@H](N)CC(F)(F)C1 CHEMBL3648754 Ki 0.002 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)ccc(I)c3F)sc2N)c1N1CC[C@H](N)CC(F)(F)C1 CHEMBL3648755 Ki 0.002 nM
COC1(C)CC(N)CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)C1 CHEMBL3648698 Ki 0.002 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@@]12CC[C@H](N)[C@@H](CC1)O2 CHEMBL3934801 Ki 0.002 nM
Cn1ncc(NC(=O)c2csc(-c3ccc(Cl)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4109634 Ki 0.002 nM
Cn1ncc(NC(=O)c2csc(-n3cc4ccccc4n3)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4113580 Ki 0.002 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cc(O[C@H]4CCOC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL3970782 Ki 0.00224 nM
O=C(Nc1c[nH]c2ncc(-c3ccccc3F)cc12)c1cnn2ccc(NC[C@H]3CCNC[C@@H]3F)nc12 CHEMBL2387464 Ki 0.003 nM
C[C@H]1O[C@@H](c2c(NC(=O)c3csc(-c4c(F)cccc4F)n3)cnn2C)C[C@@H](N)[C@]1(C)O CHEMBL3318855 Ki 0.003 nM
C/N=C(\C(C=N)NC(=O)c1nc(-c2c(F)cccc2F)sc1N)N1CC[C@@H](N)CC(F)(F)C1 CHEMBL4114779 Ki 0.003 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(C)(N)CC(F)(F)C1 CHEMBL3648851 Ki 0.003 nM
C[C@@H]1C[C@@H](N)CC[C@H](c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)O1 CHEMBL4110368 Ki 0.003 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cc(O[C@@H]4CCOC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4110034 Ki 0.003 nM
Cc1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c(F)c1 CHEMBL4106822 Ki 0.003 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)ccc(F)c3F)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4107986 Ki 0.003 nM
Cn1ncc(NC(=O)c2csc(-c3ccc(C4(C)COC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4107524 Ki 0.003 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@@](C)(N)CC(F)(F)C1 CHEMBL3623162 Ki 0.003 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4111897 Ki 0.00342 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(N)CC(F)(F)C1 CHEMBL3648676 Ki 0.004 nM
Cn1ncc(NC(=O)c2nc(-c3cc(F)ccc3F)sc2N)c1N1CC[C@H](N)CC(F)(F)C1 CHEMBL3639475 Ki 0.004 nM
COC1C(N)CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC12CC2 CHEMBL3652032 Ki 0.004 nM
CCc1cncc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)c1 CHEMBL3914022 Ki 0.004 nM
Cn1ncc(NC(=O)c2nc(-c3cccc(F)c3F)sc2N)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3918462 Ki 0.004 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)ccc(F)c3F)sc2N)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3901936 Ki 0.004 nM
Cc1cccnc1-c1nc(C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@H](F)CO2)c(N)s1 CHEMBL4109001 Ki 0.004 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@@H](N)CC(F)(F)C1 CHEMBL3623150 Ki 0.005 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4110546 Ki 0.00509 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@]12CC[C@H](O1)[C@@H](N)CC2 CHEMBL3318853 Ki 0.006 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C1 CHEMBL3651966 Ki 0.006 nM
C/N=C(\C(C=N)NC(=O)c1nc(-c2c(F)cccc2F)sc1N)N1CC[C@H](N)CC(F)(F)C1 CHEMBL4114733 Ki 0.006 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(O)CC(F)(F)C1 CHEMBL3648771 Ki 0.006 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3N3CCC(N)CC(F)(F)C3)c(N)s2)c(F)c1 CHEMBL3648832 Ki 0.006 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3919563 Ki 0.006 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCOCC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4108678 Ki 0.006 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@@]12CC[C@@H](N)[C@@H](CC1)O2 CHEMBL4109141 Ki 0.006 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccccc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C1 CHEMBL4741714 IC50 0.006 nM
O=C(Nc1c[nH]c2ncc(-c3c(F)cccc3F)cc12)c1cnn2ccc(NC[C@H]3CCNC[C@@H]3F)nc12 CHEMBL2387465 Ki 0.007 nM
O=C(Nc1c[nH]c2ncc(-c3ccccc3F)cc12)c1cnn2ccc(NCC3CCNCC3)nc12 CHEMBL2387463 Ki 0.007 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)cnc2N)c1N1CC[C@@H](N)CC(F)(F)C1 CHEMBL3648694 Ki 0.007 nM
COC1CC(N)CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)C1 CHEMBL3648733 Ki 0.007 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnn(C2CC2)c1N1CC[C@@H](N)CC(F)(F)C1 CHEMBL3648753 Ki 0.007 nM
CNC1CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC(F)(F)C1 CHEMBL3648793 Ki 0.007 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)sc2N)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3933850 Ki 0.007 nM
Cc1c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@@H](F)CO3)c(N)s2)cnn1C CHEMBL3938654 Ki 0.007 nM
Cc1cccc(F)c1-c1nc(C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@@H](F)CO2)c(N)s1 CHEMBL3922546 Ki 0.007 nM
CO[C@H]1CO[C@H](c2c(NC(=O)c3nc(-c4cc(Cl)ccc4F)sc3N)cnn2C)CC[C@H]1N CHEMBL4114955 Ki 0.007 nM
Cn1ncc(NC(=O)c2nc(-c3cccc(Cl)c3F)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4107709 Ki 0.007 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3ccc(Cl)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4114315 Ki 0.007 nM
CO[C@H]1C[C@H](N)CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)C1 CHEMBL4459538 Ki 0.007 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cc(C4(O)CCOC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4110136 Ki 0.00762 nM
N[C@H]1CCC[C@@H](Nc2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 CHEMBL3919783 Ki 0.0079 nM
Cn1ncc(NC(=O)c2nc(-c3cc(F)ccc3F)sc2N)c1N1CC[C@@H](N)CC(F)(F)C1 CHEMBL3648719 Ki 0.008 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cncc3F)sc2N)c1N1CCC(N)CC(F)(F)C1 CHEMBL3648815 Ki 0.008 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C12CCC(N)C(CC1)O2 CHEMBL3954702 Ki 0.008 nM
CO[C@H]1CO[C@H](c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC[C@H]1N CHEMBL4107009 Ki 0.008 nM
C[C@H](O)c1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c(F)c1 CHEMBL3958042 Ki 0.008 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1N1CCC[C@H](N)C1 CHEMBL3900009 Ki 0.00806 nM
O=C(Nc1c[nH]c2ncc(-c3c(F)cccc3F)cc12)c1cnn2ccc(NCC3CCNCC3)nc12 CHEMBL2387471 Ki 0.009 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(N)CC(C)(F)C1 CHEMBL3648700 Ki 0.009 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)sc2N)c1N1CC[C@@H](N)CC(F)(F)C1 CHEMBL3648723 Ki 0.009 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cncc3F)sc2N)c1N1CC[C@@H](N)CC(F)(F)C1 CHEMBL3648828 Ki 0.009 nM
COC1(C)CC(N)CCN(c2c(NC(=O)c3nc(-c4c(F)cncc4F)sc3N)cnn2C)C1 CHEMBL3648817 Ki 0.009 nM
Cn1cc(-c2cc3c(-c4ccc(Br)c(N5CCC[C@H](N)C5)n4)n[nH]c3cn2)cn1 CHEMBL3972871 Ki 0.009 nM
Cn1cc(-c2cc3c(-c4ccc(C5CC5)c(N5CCC[C@H](N)C5)n4)n[nH]c3cn2)cn1 CHEMBL3903009 Ki 0.009 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cc(C4CC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4108945 Ki 0.009 nM
Cn1ncc(NC(=O)c2csc(-c3n[nH]c4c3CCC(C)(C)C4)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4113383 Ki 0.009 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@@H]1C[C@@H](F)[C@H](N)CCO1 CHEMBL3318854 Ki 0.01 nM
Cc1cncc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)n1 CHEMBL3634783 Ki 0.01 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(F)CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1OCCC#N CHEMBL3691937 IC50 0.01 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC4CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1OCCC#N CHEMBL3691967 IC50 0.01 nM
Cc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCC#N)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687493 IC50 0.01 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3687509 IC50 0.01 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H](N)[C@H]1OCCC#N CHEMBL3687474 IC50 0.01 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnn(C)c3N3CCC[C@@H](N)CC3)c(N)s2)c1F CHEMBL3648671 Ki 0.01 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@H](N)C[C@@H](F)C1 CHEMBL3648682 Ki 0.01 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)cnc2N)c1N1CC[C@H](N)CC(F)(F)C1 CHEMBL3648693 Ki 0.01 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnn(CC(F)F)c1N1CC[C@H](N)CC(F)(F)C1 CHEMBL3648717 Ki 0.01 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)sc2N)c1N1CC[C@H](N)CC(F)(F)C1 CHEMBL3648722 Ki 0.01 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnn(C2CC2)c1N1CC[C@H](N)CC(F)(F)C1 CHEMBL3648752 Ki 0.01 nM
Cn1ncc(NC(=O)c2nc(-c3ccncc3F)sc2N)c1N1CC[C@H](N)CC(F)(F)C1 CHEMBL3648822 Ki 0.01 nM
C=C(C)c1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1N1CCC[C@H](N)C1 CHEMBL3894581 Ki 0.01 nM
C#Cc1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1N1CCC[C@H](N)C1 CHEMBL3972110 Ki 0.01 nM
Cn1ncc(NC(=O)c2nc(-c3ccc(C(F)(F)F)cc3F)sc2N)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3919573 Ki 0.01 nM
CO[C@H]1CO[C@H](c2c(NC(=O)c3nc(-c4c(F)ccc(F)c4F)sc3N)cnn2C)CC[C@H]1N CHEMBL4108653 Ki 0.01 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cc(C4(F)COC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4113050 Ki 0.01 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(N)CC(F)C1 CHEMBL4439756 Ki 0.01 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 CHEMBL3676285 Ki 0.01 nM
O=C(Nc1c[nH]c2ncccc12)c1cnn2ccc(NC[C@@H]3CCNC[C@H]3F)nc12 CHEMBL2387479 Ki 0.011 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cc(C(C)(C)O)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4111174 Ki 0.011 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cc(C4CCOC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4109372 Ki 0.011 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)ccc4[nH]ccc34)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4112826 Ki 0.011 nM
CC1CC(N)CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)C1 CHEMBL3648826 Ki 0.012 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cc(O)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4110434 Ki 0.012 nM
C[C@H]1NC(=O)c2cc(-c3c(F)ccc4c(=O)n(C)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3902148 IC50 0.012 nM
Cc1nc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cnc1N CHEMBL3959091 Ki 0.012 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cnn(C)c4)cc23)nc1N1CCC[C@H](N)C1 CHEMBL3634760 Ki 0.013 nM
COC1(C)CC(N)CCN(c2c(NC(=O)c3nc(-c4ccncc4F)sc3N)cnn2C)C1 CHEMBL3639476 Ki 0.013 nM
CCc1ccc(-c2n[nH]c3cnc(-c4cnn(CC)c4)cc23)nc1N1CCC[C@H](N)C1 CHEMBL3949620 Ki 0.013 nM
Cn1ncc(NC(=O)c2nc(-c3ccncc3F)sc2N)c1[C@@]12CC[C@@H](N)[C@@H](CC1)O2 CHEMBL4115609 Ki 0.013 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@@H]1CC[C@@H](N)C(F)(F)CO1 CHEMBL3943948 Ki 0.013 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c1F CHEMBL4113395 Ki 0.013 nM
CCn1c(NC2(C)CC2)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)c(F)ccc2c1=O CHEMBL3895124 IC50 0.013 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3939366 Ki 0.0131 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cccc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4111122 Ki 0.0137 nM
Cn1ncc(NC(=O)c2nc(-c3ccncc3F)sc2N)c1N1CC[C@@H](N)CC(F)(F)C1 CHEMBL3648823 Ki 0.014 nM
C=Cc1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1N1CCC[C@H](N)C1 CHEMBL3922596 Ki 0.014 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCNC[C@@H](O)C5)n4)n[nH]c3cn2)cn1 CHEMBL4115489 Ki 0.014 nM
FCCn1cc(-c2cc3c(-c4cccc(N5CCCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3925594 Ki 0.014 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1CC(F)(F)CC(N)CO1 CHEMBL3925922 Ki 0.014 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cc(OCCO)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3911768 Ki 0.014 nM
CO[C@H]1CO[C@H](c2c(NC(=O)c3nc(-c4c(F)cccc4Cl)sc3N)cnn2C)CC[C@H]1N CHEMBL4107753 Ki 0.014 nM
C[C@@H](O)c1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c(F)c1 CHEMBL4109272 Ki 0.014 nM
COC1(c2cc(F)c(-c3nc(C(=O)Nc4cnn(C)c4[C@@H]4CC[C@@H](N)[C@H](F)CO4)cs3)c(F)c2)COC1 CHEMBL4109861 Ki 0.014 nM
CO[C@@H]1CO[C@H](c2c(NC(=O)c3csc(-c4c(F)cccc4F)n3)cnn2C)CC[C@H]1N CHEMBL4107489 Ki 0.014 nM
CO[C@@H]1CO[C@H](c2c(NC(=O)c3csc(-c4ncccc4C)n3)cnn2C)CC[C@H]1N CHEMBL4109749 Ki 0.014 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C3CC3)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3932475 Ki 0.014 nM
CO[C@H]1CO[C@H](c2c(NC(=O)c3nc(-c4ccccc4F)sc3N)cnn2C)CC[C@H]1N CHEMBL4111393 Ki 0.0143 nM
O=C(Nc1c[nH]c2ncc(-c3c(F)cccc3F)cc12)c1cnn2ccc(CCC3CCNCC3)nc12 CHEMBL2387474 Ki 0.015 nM
CCn1cncc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)c1=O CHEMBL3634769 Ki 0.015 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)ccc(C4CC4)c3F)sc2N)c1N1CCC[C@@H](N)CC1 CHEMBL3648670 Ki 0.015 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnn(C)c3N3CC[C@H](N)CC(F)(F)C3)c(N)s2)c1 CHEMBL3648720 Ki 0.015 nM
c1cncc(-c2cc3c(-c4cccc(N5CCCNCC5)n4)n[nH]c3cn2)c1 CHEMBL3967523 Ki 0.015 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1CCC(N)C(F)CO1 CHEMBL3896956 Ki 0.015 nM
CC[C@]1(CN)CO[C@H](c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)OC1 CHEMBL3907594 Ki 0.015 nM
Cn1ncc(NC(=O)c2nc(-c3cccc(F)c3Cl)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4108233 Ki 0.015 nM
O=C(Nc1c[nH]c2ncccc12)c1cnn2ccc(NCC3(F)CCNCC3)nc12 CHEMBL2387462 Ki 0.016 nM
C=C(C)c1ccc(-c2n[nH]c3cnc(-c4cnn(CC)c4)cc23)nc1N1CCC[C@H](N)C1 CHEMBL3971218 Ki 0.016 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCNCC(CO)C5)n4)n[nH]c3cn2)cn1 CHEMBL3910119 Ki 0.016 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cc(C4(F)CCOCC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4108539 Ki 0.016 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cc(OCCO)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4108592 Ki 0.016 nM
Cc1cccc(F)c1-c1nc(C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@H](F)CO2)c(N)s1 CHEMBL4108045 Ki 0.016 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4114301 Ki 0.016 nM
N[C@@H]1CCCN(c2c(/C=C3\SC(=O)NC3=O)cccc2-c2ccccc2)C1 CHEMBL2048872 Ki 0.017 nM
N[C@H]1CCCN(c2nc(-c3n[nH]c4cnc(-c5cccnc5)cc34)ccc2Br)C1 CHEMBL3946733 Ki 0.017 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C12CCC(O)C(CC1)O2 CHEMBL3963556 Ki 0.017 nM
CO[C@H]1CO[C@H](c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC[C@@H]1N CHEMBL3950800 Ki 0.017 nM
CC(O)c1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)ccc2F)c(F)c1 CHEMBL4107052 Ki 0.017 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnn(C)c3N3CC[C@@H](N)CC(F)(F)C3)c(N)s2)c1 CHEMBL3648721 Ki 0.018 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnn(CC(F)F)c1N1CCC(N)C(O)CC1 CHEMBL3648790 Ki 0.018 nM
Cc1c(-c2nc(C(=O)Nc3cnn(C)c3N3CC[C@@H](N)CC(F)(F)C3)c(N)s2)cnn1C CHEMBL3648836 Ki 0.018 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cc(OC4CCOCC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4114036 Ki 0.018 nM
Cn1ncc(NC(=O)c2nc(-c3cc(Cl)ccc3F)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4113425 Ki 0.018 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cc(C(C)(F)F)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4109607 Ki 0.018 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3982539 Ki 0.018 nM
COc1ccc(-n2ncc3cnc(-c4cncc(C)n4)cc32)nc1N1CCC[C@H](N)C1 CHEMBL3914639 Ki 0.018 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnn(C)c3N3CCNCC(F)(F)C3)c(N)s2)c1 CHEMBL3648660 Ki 0.019 nM
Cn1ncc(NC(=O)c2nc(-c3ccccn3)sc2N)c1N1CC[C@@H](N)CC(F)(F)C1 CHEMBL3648704 Ki 0.019 nM
CO[C@@H]1[C@H](N)CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC12CC2 CHEMBL3648861 Ki 0.019 nM
N[C@H]1CCCN(c2nc(-c3n[nH]c4cnc(-c5cccnc5)cc34)ccc2Cl)C1 CHEMBL3893927 Ki 0.019 nM
Cc1cncc(-c2cc3c(-c4cccc(N5CCCNCC5)n4)n[nH]c3cn2)n1 CHEMBL3978766 Ki 0.019 nM
C[C@@H]1CC(N)CC[C@H](c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)O1 CHEMBL4112467 Ki 0.019 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@H]1C[C@@H](N)CCO1 CHEMBL3978459 Ki 0.019 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)ccc2F)c(F)c1 CHEMBL4106937 Ki 0.019 nM
Cn1ncc(NC(=O)c2nc(-c3cccc(F)c3F)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4106982 Ki 0.019 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3634767 Ki 0.02 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC4CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691955 IC50 0.02 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1cncn1 CHEMBL3687466 IC50 0.02 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)C[C@@H](N)[C@H]1OCCC#N CHEMBL3691968 IC50 0.02 nM
Cc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCS(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687483 IC50 0.02 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC(C)C)cc3F)n2)C[C@@H]1C CHEMBL3691926 IC50 0.02 nM
Cc1cc(F)c(-c2nc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691945 IC50 0.02 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691960 IC50 0.02 nM
CC(C)Oc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCS(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691925 IC50 0.02 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC4CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3691943 IC50 0.02 nM
COC(=O)N(C)[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C)cc3F)n2)C[C@@H]1C CHEMBL3687468 IC50 0.02 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1OCCS(C)(=O)=O CHEMBL3687527 IC50 0.02 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)C[C@@H](N)[C@@H]1OCCS(C)(=O)=O CHEMBL3691923 IC50 0.02 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCC#N)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691949 IC50 0.02 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC(C)C)cc3F)n2)C[C@@H]1C CHEMBL3687511 IC50 0.02 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC4CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3691921 IC50 0.02 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H]1C CHEMBL3691958 IC50 0.02 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC4CCOCC4)cc3F)n2)C[C@@H](N)[C@@H]1OCCS(C)(=O)=O CHEMBL3691924 IC50 0.02 nM
CS[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687443 IC50 0.02 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@H]1OCCS(C)(=O)=O CHEMBL3691930 IC50 0.02 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C(C)C)cc3F)n2)C[C@@H]1C CHEMBL3687505 IC50 0.02 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCS(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691928 IC50 0.02 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC(C)C)cc3F)n2)C[C@@H]1C CHEMBL3691932 IC50 0.02 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H](N)[C@H]1OCCS(C)(=O)=O CHEMBL3691919 IC50 0.02 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@H]1OCCC#N CHEMBL3691950 IC50 0.02 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)ccc2N)c1N1CC[C@H](N)CC(F)(F)C1 CHEMBL3648695 Ki 0.02 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnn(CC(F)F)c1N1CC[C@@H](N)CC(F)(F)C1 CHEMBL3648718 Ki 0.02 nM
N[C@@H]1CCCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)CC1 CHEMBL4113655 Ki 0.02 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3895582 Ki 0.02 nM
CCn1cc(-c2cc3c(-c4ccc(C(C)C)c(N5CCC[C@H](N)C5)n4)n[nH]c3cn2)cn1 CHEMBL3972403 Ki 0.02 nM
CO[C@H]1CO[C@H](c2c(NC(=O)c3nc(-c4cc(C)ccc4F)sc3N)cnn2C)CC[C@H]1N CHEMBL4109191 Ki 0.02 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@@H](F)CO3)c(N)s2)c1 CHEMBL3899457 Ki 0.02 nM
Cn1ncc(NC(=O)c2csc(-n3ncc4c3CCCC4)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4111317 Ki 0.02 nM
c1cc(N2CCNCC2)nc(-n2ncc3cnc(-c4cncc(N5CCC5)n4)cc32)c1 CHEMBL3951741 Ki 0.02 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)n1 CHEMBL3960554 Ki 0.02 nM
Cc1cncc(-c2cc3c(cnn3-c3cccc(N4CCCNCC4)n3)nn2)n1 CHEMBL4091687 Ki 0.02 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC[C@H](N)CC1 CHEMBL4437940 Ki 0.02 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CC5(N)CC5)c(NC5(C)CC5)nc34)[nH]c21 CHEMBL4513589 IC50 0.02 nM
c1cc(-c2n[nH]c3cnc(-c4cnn(CC5CC5)c4)cc23)nc(N2CCNCC2)c1 CHEMBL3634772 Ki 0.021 nM
C[C@@H]1CC[C@H](N)CN1c1ccncc1Nc1ncc2ccc(-c3c(F)cccc3F)nn12 CHEMBL3965757 IC50 0.021 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)ccc2N)c1N1CCC(N)CC(F)(F)C1 CHEMBL3648727 Ki 0.021 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCCC(C)(N)CC1 CHEMBL3648795 Ki 0.021 nM
COc1cncc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)c1 CHEMBL3905023 Ki 0.021 nM
CCn1cc(-c2cc3c(-c4ccc(C5CC5)c(N5CCC[C@H](N)C5)n4)n[nH]c3cn2)cn1 CHEMBL3899964 Ki 0.021 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4109184 Ki 0.021 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cc(C(C)(C)O)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4115417 Ki 0.021 nM
Cn1ncc(NC(=O)c2csc(-c3ccccc3)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4106898 Ki 0.021 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)n1 CHEMBL3943705 Ki 0.021 nM
N#CCn1cc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3634771 Ki 0.022 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCCC2(CCCN2)CC1 CHEMBL3648759 Ki 0.022 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC2NCCOC2CC1 CHEMBL3648789 Ki 0.022 nM
CCc1ccc(-c2n[nH]c3cnc(-c4cnn(C)c4)cc23)nc1N1CCC[C@H](N)C1 CHEMBL3962485 Ki 0.022 nM
N[C@H]1CCCN(c2nc(-c3n[nH]c4cnc(-c5cccnc5)cc34)ccc2C2CC2)C1 CHEMBL3940007 Ki 0.022 nM
FC(F)(F)Cn1cc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3897509 Ki 0.022 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cc(C4(F)COC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4106721 Ki 0.022 nM
Cn1ncc(NC(=O)c2csc(-c3n[nH]c4ccccc34)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4110513 Ki 0.022 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)cnc2N)c1N1CCC(N)CC(F)(F)C1 CHEMBL3648728 Ki 0.023 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cncc3F)sc2N)c1N1CC[C@H](N)CC(F)(F)C1 CHEMBL3648827 Ki 0.023 nM
C=Cc1ccc(-c2n[nH]c3cnc(-c4cnn(CC)c4)cc23)nc1N1CCC[C@H](N)C1 CHEMBL3890600 Ki 0.023 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)ccc2F)c(F)c1 CHEMBL4112262 Ki 0.023 nM
Cn1ncc(NC(=O)c2csc(-c3cc(Br)ccc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4114425 Ki 0.023 nM
Cn1ncc(NC(=O)c2csc(-c3n[nH]c4c3CCCC4)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4109317 Ki 0.023 nM
Nc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)n1 CHEMBL3961692 Ki 0.023 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC[C@@H](N)CC1 CHEMBL3652638 Ki 0.024 nM
C[C@@H]1C[C@H](N)CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C1 CHEMBL3942186 IC50 0.024 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)sc2N)c1N1CCCC(C)(N)CC1 CHEMBL3648796 Ki 0.024 nM
CC1CN(c2cccc(-c3n[nH]c4cnc(-c5cnn(CCF)c5)cc34)n2)CCN1 CHEMBL3970485 Ki 0.024 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)c(N)s2)c1 CHEMBL4106948 Ki 0.024 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cc4c(c3F)OCC4)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4113411 Ki 0.024 nM
O=C(Nc1c[nH]c2ncccc12)c1cnn2ccc(NC[C@H]3CCNC[C@@H]3F)nc12 CHEMBL2387478 Ki 0.025 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCNCC2(CC2)C1 CHEMBL3648731 Ki 0.025 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(N)C2(CCO2)CC1 CHEMBL3648853 Ki 0.025 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1N1CCC[C@H](N)CC1 CHEMBL3903449 Ki 0.025 nM
N[C@@H]1CCC[C@@H](Nc2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 CHEMBL4112372 Ki 0.025 nM
N[C@H]1CCCCN(c2cccc(-c3n[nH]c4cnc(-c5cnn(CCF)c5)cc34)n2)C1 CHEMBL3892821 Ki 0.025 nM
CC[C@]1(CO)CO[C@H](c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)OC1 CHEMBL3973524 Ki 0.025 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@@H](F)CO3)ccc2F)c(F)c1 CHEMBL3939746 Ki 0.025 nM
Cc1c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)c(N)s2)cnn1C CHEMBL4109239 Ki 0.025 nM
CN(C)[C@H]1CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC(F)(F)C1 CHEMBL3648725 Ki 0.026 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(N)C(O)CC1 CHEMBL3648741 Ki 0.026 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1CC[C@@H](N)[C@H](F)CC1 CHEMBL3648762 Ki 0.026 nM
Cc1c(-c2nc(C(=O)Nc3cnn(C)c3N3CCC(N)CC(F)(F)C3)c(N)s2)cnn1C CHEMBL3648833 Ki 0.026 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@](C)(N)CC(F)(F)C1 CHEMBL3652035 Ki 0.026 nM
CCn1cc(-c2cc3c(-c4ccc(Br)c(N5C[C@@H](N)C[C@@H](F)C5)n4)n[nH]c3cn2)cn1 CHEMBL4111907 Ki 0.026 nM
C[C@@H]1CN(c2cccc(-c3n[nH]c4cnc(-c5cnn(CCF)c5)cc34)n2)CCN1 CHEMBL4107084 Ki 0.026 nM
CO[C@@H]1COC(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC[C@H]1N CHEMBL4112716 Ki 0.026 nM
Cc1nn(C)cc1-c1nc(C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@@H](F)CO2)c(N)s1 CHEMBL3965176 Ki 0.026 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cnc(C3CC3)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3920778 Ki 0.026 nM
OCCNc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3946464 Ki 0.026 nM
N[C@H]1CCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 CHEMBL3902873 Ki 0.0268 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCCC(N)CC1 CHEMBL3652626 Ki 0.027 nM
Cn1ncc(NC(=O)c2nc(-c3ncccc3F)sc2N)c1N1CC[C@H](N)CC(F)(F)C1 CHEMBL3648706 Ki 0.027 nM
N[C@@H]1CCCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 CHEMBL4108413 Ki 0.027 nM
CCn1cc(-c2cc3c(-c4ccc(C)c(N5CCC[C@H](N)C5)n4)n[nH]c3cn2)cn1 CHEMBL3918555 Ki 0.027 nM
CC(O)c1cncc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)c1 CHEMBL3948781 Ki 0.027 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@H]1CC[C@H](CN)O1 CHEMBL4107082 Ki 0.027 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@@H](F)CO3)ccc2F)c(F)c1 CHEMBL3972439 Ki 0.027 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cc(C4(O)CCC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4114448 Ki 0.027 nM
N[C@@H]1CCCN(c2nc(-c3n[nH]c4cnc(-c5cccnc5)cc34)ccc2Br)CC1 CHEMBL4114430 Ki 0.028 nM
C=C(C)c1ccc(-c2n[nH]c3cnc(-c4cnn(C)c4)cc23)nc1N1CCC[C@H](N)C1 CHEMBL3933509 Ki 0.028 nM
CCn1cc(-c2cc3c(-c4ccc(Br)c(N5C[C@H](N)C[C@@H](F)C5)n4)n[nH]c3cn2)cn1 CHEMBL4114499 Ki 0.028 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cc(C4(O)CC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4109566 Ki 0.028 nM
Cn1ncc(NC(=O)c2nc(-c3cccc(C(F)(F)F)c3F)sc2N)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3968011 Ki 0.028 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CC(N)CCC3C)n2)n1 CHEMBL3976267 Ki 0.028 nM
CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2[nH]c1=O CHEMBL3918907 IC50 0.0282 nM
N[C@H]1CCCN(c2nc(-c3n[nH]c4cnc(-c5cccnc5)cc34)ccc2Br)CC1 CHEMBL3902989 Ki 0.029 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cnn(C)c4)cc23)nc1N1CCN(C)CC1 CHEMBL3926542 Ki 0.029 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCNC(C)(C)C5)n4)n[nH]c3cn2)cn1 CHEMBL3895992 Ki 0.029 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCNCC(F)(F)C5)n4)n[nH]c3cn2)cn1 CHEMBL3932937 Ki 0.029 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@H]1OC[C@H](CN)CO1 CHEMBL3976609 Ki 0.029 nM
CC(O)c1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c(F)c1 CHEMBL4111956 Ki 0.029 nM
CCn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)c(F)ccc2c1=O CHEMBL3960373 IC50 0.029 nM
C[C@H]1CN(c2cccc(-c3n[nH]c4cnc(-c5cnn(CCF)c5)cc34)n2)CCN1 CHEMBL3908352 Ki 0.0294 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)C3(CC3)NC4=O)c2nc1NC1(C)CC1 CHEMBL3949102 IC50 0.0295 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)C[C@@H]1C CHEMBL3691922 IC50 0.03 nM
COC(=O)N(C)[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687471 IC50 0.03 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C)cc3F)n2)C[C@@H]1C CHEMBL3687490 IC50 0.03 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1cncn1 CHEMBL3687459 IC50 0.03 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1cc(CO)nn1 CHEMBL3687476 IC50 0.03 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H]1C CHEMBL3687492 IC50 0.03 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691963 IC50 0.03 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1N=[N+]=[N-] CHEMBL3687497 IC50 0.03 nM
CCO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687498 IC50 0.03 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691977 IC50 0.03 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H]1C CHEMBL3687482 IC50 0.03 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3687418 IC50 0.03 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1OCCC#N CHEMBL3687495 IC50 0.03 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4CCS(=O)(=O)CC4)cc3F)n2)C[C@@H]1C CHEMBL3687504 IC50 0.03 nM
Cc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691965 IC50 0.03 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3639863 IC50 0.03 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C)cc3F)n2)C[C@@H]1C CHEMBL3687472 IC50 0.03 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1Oc1ccccn1 CHEMBL3687532 IC50 0.03 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCS(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691914 IC50 0.03 nM
CC(C)Oc1cc(F)c(-c2nc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691931 IC50 0.03 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C)cc3F)n2)C[C@@H]1C CHEMBL3687512 IC50 0.03 nM
Cn1ncc(NC(=O)c2nc(-c3cc(F)ccc3F)sc2N)c1N1CCNCC(F)(F)C1 CHEMBL3648661 Ki 0.03 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)ccc2N)c1N1CC[C@@H](N)CC(F)(F)C1 CHEMBL3648696 Ki 0.03 nM
Cc1nn(C)cc1-c1nc(C(=O)Nc2cnn(C)c2N2CC[C@@H](N)CC(F)(F)C2)c(N)s1 CHEMBL3648835 Ki 0.03 nM
NCC[C@@H]1CCCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 CHEMBL3918702 Ki 0.03 nM
N[C@@H]1CCCN(c2cncc(-c3cc4c(-c5ccccc5F)n[nH]c4cn3)n2)CC1 CHEMBL4115471 Ki 0.03 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCC[C@@H](N)CC5)n4)n[nH]c3cn2)cn1 CHEMBL4107359 Ki 0.03 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1N1CCC[C@@H](N)CC1 CHEMBL4115125 Ki 0.03 nM
Cn1cc(-c2cc3c(-c4ccc(Br)c(N5CCC(N)CC5)n4)n[nH]c3cn2)cn1 CHEMBL3927435 Ki 0.03 nM
Cn1cc(-c2cc3c(-c4ccc(Br)c(N5C[C@@H](N)C[C@@H](F)C5)n4)n[nH]c3cn2)cn1 CHEMBL4107502 Ki 0.03 nM
N[C@@H]1CCCC(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 CHEMBL4111381 Ki 0.03 nM
CCn1cc(-c2cc3c(-c4ccc(C)c(N5C[C@@H](N)C[C@@H](F)C5)n4)n[nH]c3cn2)cn1 CHEMBL4115239 Ki 0.03 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cc(OC4CCOCC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3946292 Ki 0.03 nM
Cn1ncc(NC(=O)c2nc(C3=CCCC3)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4112068 Ki 0.03 nM
COc1ccc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](OC)CO3)cs2)c1F CHEMBL4108074 Ki 0.03 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1CCC(N)C(F)CC1 CHEMBL4469964 Ki 0.03 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@@H](N)[C@@H](O)CC1 CHEMBL4453890 Ki 0.03 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@@H](N)[C@H](F)CC1 CHEMBL3648680 Ki 0.03 nM
Nc1ccc(-c2ccccc2F)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 CHEMBL3103867 Ki 0.03 nM
CC(c1cn(C)cn1)n1c(NC2(C)CC2)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccc2c1=O CHEMBL4471849 IC50 0.03 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n([C@@H](C)c5cn(C)cn5)c(NC5(C)CC5)nc34)[nH]c21 CHEMBL4450494 IC50 0.03 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(N)CC2(CCO2)C1 CHEMBL3648824 Ki 0.031 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCC[C@H](N)C5)n4)n[nH]c3cn2)cn1 CHEMBL3923994 Ki 0.031 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@H]1CC[C@H](N)C(F)(F)CO1 CHEMBL4113957 Ki 0.031 nM
COCc1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)ccc2F)c(F)c1 CHEMBL4115331 Ki 0.031 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)ccc(F)c3F)n2)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3933891 Ki 0.031 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c(F)c1 CHEMBL4115274 Ki 0.031 nM
Cn1ncc(NC(=O)c2csc(-c3cc(Cl)ccc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4108082 Ki 0.031 nM
Cn1ncc(NC(=O)c2csc(-c3ccccn3)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4114312 Ki 0.031 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)ccc(C(F)F)c3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4107399 Ki 0.031 nM
Cn1ncc(NC(=O)c2nc(-c3ncccc3F)sc2N)c1N1CC[C@@H](N)CC(F)(F)C1 CHEMBL3648715 Ki 0.032 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1N1CCN(C)CC1 CHEMBL3895332 Ki 0.032 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@]12CC[C@H](O1)[C@@H](O)CC2 CHEMBL3984745 Ki 0.032 nM
CC(C)c1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)c1 CHEMBL3975764 Ki 0.032 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(O)(CN)CC1 CHEMBL3648841 Ki 0.033 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C3CC3)c(N3CCC[C@H](N)C3)n2)c1 CHEMBL3930816 Ki 0.033 nM
Cc1nc2cccc(-c3[nH]c4c(c3Cl)C(=O)NC4)c2nc1NC1(C)CC1 CHEMBL3933056 IC50 0.0339 nM
Cn1ncc(NC(=O)c2nc(-c3ccncc3F)sc2N)c1N1CCC(N)CC(F)(F)C1 CHEMBL3648807 Ki 0.034 nM
Cn1cc(-c2cc3c(-c4cccc(NCC(C)(C)O)n4)n[nH]c3cn2)cn1 CHEMBL3925682 Ki 0.034 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCC[C@H](N)CC5)n4)n[nH]c3cn2)cn1 CHEMBL3924841 Ki 0.034 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)COC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4106673 Ki 0.034 nM
CCC(=O)c1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)ccc2F)c(F)c1 CHEMBL4108143 Ki 0.034 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@@H](OC)CO3)cs2)c(F)c1 CHEMBL4107515 Ki 0.034 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)ccc(C4CC4)c3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4109164 Ki 0.034 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC(O)C3)n2)n1 CHEMBL3905519 Ki 0.034 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCC(N)C3C)n2)n1 CHEMBL3927952 Ki 0.034 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C(F)(F)F)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3961823 Ki 0.034 nM
OCCCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3910536 Ki 0.034 nM
Cn1cc(-c2cc3c(-c4cccc(N5CC[C@@H](N)C5)n4)n[nH]c3cn2)cn1 CHEMBL3634757 Ki 0.035 nM
C[C@@H]1CCN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C[C@H]1N CHEMBL3896244 IC50 0.035 nM
COC1(C)CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CCC1N CHEMBL3648845 Ki 0.035 nM
CCOC1CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CCC1N CHEMBL3648780 Ki 0.035 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCCC(F)(CN)CC1 CHEMBL3652033 Ki 0.035 nM
CCc1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1N1CCC[C@H](N)C1 CHEMBL3890794 Ki 0.035 nM
N[C@H]1CCCN(c2cccc(-c3n[nH]c4cnc(-c5cncs5)cc34)n2)C1 CHEMBL3951717 Ki 0.035 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cc(C4(O)COC4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4111312 Ki 0.035 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@@H](F)CO3)cs2)c(F)c1 CHEMBL3929166 Ki 0.035 nM
CO[C@@H]1CO[C@H](c2c(NC(=O)c3csc(-c4c(F)cc(C)cc4F)n3)cnn2C)CC[C@H]1N CHEMBL4108804 Ki 0.035 nM
COc1cccc(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c1 CHEMBL4111420 Ki 0.035 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCC[C@@H](N)C5)n4)n[nH]c3cn2)cn1 CHEMBL3634756 Ki 0.0355 nM
O=C(Nc1c[nH]c2ncccc12)c1cnn2ccc(NCC3CCNCC3)nc12 CHEMBL2387470 Ki 0.036 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3634770 Ki 0.036 nM
COC1CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C2CC2)CCC1N CHEMBL3648791 Ki 0.036 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(N)C(C(F)F)CC1 CHEMBL3648859 Ki 0.036 nM
N[C@@H]1CCCN(c2cccc(-c3n[nH]c4cnc(-c5cncs5)cc34)n2)C1 CHEMBL4107038 Ki 0.036 nM
C=Cc1ccc(-c2n[nH]c3cnc(-c4cnn(C)c4)cc23)nc1N1CCC[C@H](N)C1 CHEMBL3942480 Ki 0.036 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@H]1OC[C@](C)(CN)CO1 CHEMBL3931246 Ki 0.036 nM
COc1ccc(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)ccc2F)c(F)c1 CHEMBL4110594 Ki 0.036 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4110700 Ki 0.036 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3Cl)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4111624 Ki 0.036 nM
COc1cccc(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c1F CHEMBL4108356 Ki 0.036 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cc(Cl)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4111887 Ki 0.036 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C(F)F)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3940744 Ki 0.036 nM
C[C@H]1CC[C@H](N)CN1c1ccncc1Nc1ncc2ccc(-c3c(F)cccc3F)nn12 CHEMBL3900646 IC50 0.037 nM
c1cncc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)c1 CHEMBL3634781 Ki 0.037 nM
COC(C)c1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@@H](F)CO3)ccc2F)c(F)c1 CHEMBL3898682 Ki 0.037 nM
Cn1ncc(NC(=O)c2nc(-c3cc(F)cc(F)c3F)sc2N)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3895936 Ki 0.037 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cc(C(O)C4CC4)cc3F)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4115413 Ki 0.037 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1NC1(C)CC1 CHEMBL3949318 IC50 0.0376 nM
O=C(Nc1c[nH]c2ccc(-c3c(F)cccc3F)nc12)c1cnn2ccc(NCC3CCNCC3)nc12 CHEMBL2387473 Ki 0.038 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnn(C)c3N3CC[C@@H](N)[C@@H](F)CC3)c(N)s2)c1 CHEMBL3648707 Ki 0.038 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(N)C(O)(CCO)CC1 CHEMBL3648855 Ki 0.038 nM
NC1CCCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)CC1 CHEMBL3891654 Ki 0.038 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cccc3F)n2)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3932403 Ki 0.038 nM
c1cc(N2CCCNCC2)nc(-n2ncc3cnc(-c4cncc(C5CC5)c4)cc32)c1 CHEMBL3951088 Ki 0.038 nM
O[C@H]1CNCCN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)C1 CHEMBL3909280 Ki 0.038 nM
COC1(CN)CCCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC1 CHEMBL3652034 Ki 0.039 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCCC(N)CC5)n4)n[nH]c3cn2)cn1 CHEMBL3937913 Ki 0.039 nM
CCCn1cc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3944261 Ki 0.039 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCNC[C@H](O)C5)n4)n[nH]c3cn2)cn1 CHEMBL3954635 Ki 0.039 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cc(F)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4111279 Ki 0.039 nM
O=C(Nc1c[nH]c2ncc(-c3c(F)cccc3F)cc12)c1cnn2ccc(OCC3CCNCC3)nc12 CHEMBL2387475 Ki 0.04 nM
O=C(Nc1c[nH]c2ncccc12)c1cnn2ccc(NCCc3ccccc3)nc12 CHEMBL2387469 Ki 0.04 nM
CCO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H]1C CHEMBL3687481 IC50 0.04 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OC)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687503 IC50 0.04 nM
CCOCc1cc(F)c(-c2nc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691941 IC50 0.04 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3691961 IC50 0.04 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)C[C@@H]1C CHEMBL3691942 IC50 0.04 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691956 IC50 0.04 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687491 IC50 0.04 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnccc3C3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691916 IC50 0.04 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691976 IC50 0.04 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H]1C CHEMBL3691929 IC50 0.04 nM
COCc1cn([C@@H]2[C@H](N)CN(c3ccncc3NC(=O)c3ccc(F)c(-c4c(F)cccc4F)n3)C[C@@H]2C)nn1 CHEMBL3687427 IC50 0.04 nM
Cc1cn([C@@H]2[C@H](N)CN(c3ccncc3NC(=O)c3ccc(F)c(-c4c(F)cccc4F)n3)C[C@@H]2C)nn1 CHEMBL3687420 IC50 0.04 nM
CCOCc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCS(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687534 IC50 0.04 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H]1C CHEMBL3687479 IC50 0.04 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C(C)(C)O)cc3F)n2)C[C@@H]1C CHEMBL3687507 IC50 0.04 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)C12OCCO2 CHEMBL3687452 IC50 0.04 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(F)CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3687506 IC50 0.04 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)C[C@@H]1C CHEMBL3687508 IC50 0.04 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691952 IC50 0.04 nM
C=C(C)c1cn([C@@H]2[C@H](N)C[C@H](c3ccncc3NC(=O)c3ccc(F)c(-c4c(F)cccc4F)n3)C[C@@H]2C)nn1 CHEMBL3691971 IC50 0.04 nM
C[C@H]1CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691940 IC50 0.04 nM
CCOCc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@H](OC)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691920 IC50 0.04 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1OCCS(C)(=O)=O CHEMBL3687487 IC50 0.04 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(F)CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691935 IC50 0.04 nM
N[C@@H]1CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C[C@H](N)[C@H]1O CHEMBL3950251 IC50 0.04 nM
C[C@H]1CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C[C@@H](N)[C@@H]1O CHEMBL3966732 IC50 0.04 nM
Cn1cc(-c2cc3c(-c4cccc(N[C@H]5CC[C@@H](N)CC5)n4)n[nH]c3cn2)cn1 CHEMBL3941538 Ki 0.04 nM
CCn1cc(-c2cc3c(-c4ccc(Br)c(N5CCC[C@H](N)C5)n4)n[nH]c3cn2)cn1 CHEMBL3973525 Ki 0.04 nM
Cn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](CCN)NC4=O)cccc2c1=O CHEMBL3909351 IC50 0.04 nM
FC1CCNCC1c1cccc(-n2ncc3cnc(-c4cnn(CC(F)(F)F)c4)cc32)n1 CHEMBL3900425 Ki 0.04 nM
N[C@H]1CCCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 CHEMBL3956349 Ki 0.04 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@@H](N)C(F)(F)CC1 CHEMBL4450356 Ki 0.04 nM
Cc1cncc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)c1 CHEMBL3634782 Ki 0.041 nM
Cc1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)ccc2F)c(F)c1 CHEMBL4112985 Ki 0.041 nM
CC[C@H]1CN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC[C@@]1(CN)OC CHEMBL3648852 Ki 0.042 nM
NCC[C@H]1CCCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 CHEMBL4108655 Ki 0.042 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(N)CC(C)(O)C1 CHEMBL3648699 Ki 0.043 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(O)CC(F)C1 CHEMBL3648701 Ki 0.043 nM
CN[C@H]1CCCN(c2c(NC(=O)c3nc(-c4cc(C)ccc4F)sc3N)cnn2CC(F)F)CC1 CHEMBL3648674 Ki 0.044 nM
Cn1ncc(NC(=O)c2csc(-c3cccc(F)c3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4111105 Ki 0.044 nM
CCNc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3891387 Ki 0.044 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)sc2N)c1N1CCNC[C@]2(CCO2)C1 CHEMBL3648842 Ki 0.045 nM
C[C@]1(N)CCCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 CHEMBL3971047 Ki 0.045 nM
N[C@H]1CCCC(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 CHEMBL3982705 Ki 0.045 nM
Cc1cccnc1-c1nc(C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@H](F)CO2)cs1 CHEMBL4107807 Ki 0.045 nM
Cc1nc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](N)C3)n2)cnc1N CHEMBL3906798 Ki 0.045 nM
CC(C)c1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1N1CCC[C@H](N)C1 CHEMBL3943830 Ki 0.046 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCN[C@H](C)C5)n4)n[nH]c3cn2)cn1 CHEMBL4113217 Ki 0.046 nM
NC1CN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)CCC1F CHEMBL3980904 Ki 0.046 nM
C[C@H]1NC(=O)c2cc(-c3c(F)ccc4c3N=C(NC3(C)CC3)N(C3CC3)C4)[nH]c21 CHEMBL3949175 IC50 0.046 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNC(C)C3)n2)n1 CHEMBL3937096 Ki 0.046 nM
C=C1C[C@@H](N)CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)C1 CHEMBL3648825 Ki 0.047 nM
CO[C@@H]1CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC2(CC2)[C@@H]1N CHEMBL3648862 Ki 0.047 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)ccc(F)c3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4106499 Ki 0.047 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](N)C3)n2)n1 CHEMBL3896312 Ki 0.047 nM
Cc1ccc(-n2ncc3cnc(-c4cnn(CC(F)(F)F)c4)cc32)nc1N1CCNC[C@@H](O)C1 CHEMBL4109699 Ki 0.047 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCC[C@@H](N)C5)n4)n[nH]c3cn2)cn1 CHEMBL4087164 Ki 0.0473 nM
CNCC1CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC1 CHEMBL3648656 Ki 0.048 nM
N[C@H]1CCCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)CC1 CHEMBL3913942 Ki 0.048 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c1 CHEMBL4113320 Ki 0.048 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(C3CCCC(N)C3)n2)n1 CHEMBL3929011 Ki 0.048 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(F)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3953164 Ki 0.048 nM
OC1CN(c2cncc(-c3cc4c(cn3)cnn4-c3cccc(N4CCNCC4)n3)n2)C1 CHEMBL3975756 Ki 0.048 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC2(CC1)CNCCO2 CHEMBL3648844 Ki 0.049 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1N1CCC(N)CC1 CHEMBL3943091 Ki 0.049 nM
CCn1cc(-c2cc3c(-c4cc(C)cc(N5CCCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3957328 Ki 0.049 nM
CS(=O)(=O)c1cncc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)c1 CHEMBL3949702 Ki 0.049 nM
C[C@@H]1CC(O)CC[C@H](c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)O1 CHEMBL4108744 Ki 0.049 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@H](OC)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691927 IC50 0.05 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691938 IC50 0.05 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(F)CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3691982 IC50 0.05 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1N CHEMBL3687430 IC50 0.05 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC)cc3F)n2)C[C@@H]1C CHEMBL3691957 IC50 0.05 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC4CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1S(C)(=O)=O CHEMBL3687517 IC50 0.05 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@H](OC)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687533 IC50 0.05 nM
CCO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C)cc3F)n2)C[C@@H]1C CHEMBL3687501 IC50 0.05 nM
CCOCc1cc(F)c(-c2nc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](NC(=O)OC)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691986 IC50 0.05 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(F)CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1OCCS(C)(=O)=O CHEMBL3691913 IC50 0.05 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(F)CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3687536 IC50 0.05 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691944 IC50 0.05 nM
C[C@H]1CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691915 IC50 0.05 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1S(C)(=O)=O CHEMBL3687530 IC50 0.05 nM
Cc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](S(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687531 IC50 0.05 nM
C[C@H]1CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691978 IC50 0.05 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1cc(C2CC2)nn1 CHEMBL3691970 IC50 0.05 nM
CC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687433 IC50 0.05 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(F)C(C)(N)CC1 CHEMBL3648863 Ki 0.05 nM
CO[C@H]1CO[C@H](c2c(NC(=O)c3nc(-c4cccc(F)c4F)sc3N)cnn2C)CC[C@H]1N CHEMBL4107641 Ki 0.05 nM
Cn1ncc(NC(=O)c2csc(-c3ccc(F)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4112670 Ki 0.05 nM
CO[C@@H]1CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC[C@H]1N CHEMBL3648724 Ki 0.05 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5(C)CC5)c(NC5(C)CC5)nc34)[nH]c21 CHEMBL4568404 IC50 0.05 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnn(CC(F)F)c1N1CC[C@@H](O)[C@@H](N)CC1 CHEMBL3648773 Ki 0.051 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCCCC(N)C5)n4)n[nH]c3cn2)cn1 CHEMBL3901549 Ki 0.051 nM
Cn1ccc(-c2n[nH]c3cnc(-c4cncc(N5CCC(N)CC5)n4)cc23)n1 CHEMBL3923115 Ki 0.051 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cnn(C)c4)cc23)nc1N1CCNCC1 CHEMBL3955675 Ki 0.051 nM
Cn1ncc(NC(=O)c2nc(-c3ccncc3F)sc2N)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3947436 Ki 0.051 nM
OC[C@@H]1CCCN1c1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3907493 Ki 0.051 nM
N#Cc1ccc(Cc2cc(O)n3ncc(C(=O)Nc4c[nH]c5ncccc45)c3n2)cc1 CHEMBL2387468 Ki 0.052 nM
COC1CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CCC1N CHEMBL3648732 Ki 0.052 nM
Cn1cc(-c2cc3c(-c4ccnc(N5CCC[C@@H](N)C5)n4)n[nH]c3cn2)cn1 CHEMBL4106536 Ki 0.052 nM
CO[C@H]1CO[C@H](c2c(NC(=O)c3nc(-c4c(C)cccc4F)sc3N)cnn2C)CC[C@H]1N CHEMBL4109373 Ki 0.052 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)sc2N)c1C12CCC(CN)(CC1)O2 CHEMBL3900444 Ki 0.053 nM
CC(O)c1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@@H](F)CO3)ccc2F)c(F)c1 CHEMBL3900514 Ki 0.053 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3C(F)(F)F)sc2N)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3955893 Ki 0.053 nM
COc1ccc(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@@H](F)CO3)cs2)c(F)c1 CHEMBL3920787 Ki 0.053 nM
COc1ccc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c1 CHEMBL4113939 Ki 0.053 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(C3CNCCC3(F)F)n2)n1 CHEMBL3926007 Ki 0.053 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1CCC(O)CCO1 CHEMBL3897552 Ki 0.054 nM
Cn1ncc(NC(=O)c2csc(-c3cccc(Cl)c3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4108977 Ki 0.054 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1N1CC[C@@H](N)C1 CHEMBL4078203 Ki 0.0549 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCCC(O)(C(F)(F)F)CC1 CHEMBL3648792 Ki 0.055 nM
COC1CCC(c2c(NC(=O)c3nc(-c4ccccc4F)sc3N)cnn2C)CCC1N CHEMBL3648856 Ki 0.055 nM
CCn1cc(-c2cc3c(-c4ccc(C)c(N5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3967325 Ki 0.055 nM
CCn1cc(-c2cc3c(-c4cccc(NC5CCCCNC5)n4)n[nH]c3cn2)cn1 CHEMBL3948867 Ki 0.055 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C3CC3)c(N3CCCNCC3)n2)n1 CHEMBL3922549 Ki 0.055 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC2(CCNC2)CC1 CHEMBL3648679 Ki 0.056 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCCC(N)C(F)C1 CHEMBL3648675 Ki 0.056 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cnn(C)c4)cc23)nc1N1C[C@@H](N)C[C@@H](F)C1 CHEMBL4112298 Ki 0.056 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](O)CO3)ccc2F)c(F)c1 CHEMBL4108748 Ki 0.056 nM
COC1(c2cc(F)c(-c3nc(C(=O)Nc4cnn(C)c4[C@@H]4CC[C@@H](N)[C@H](F)CO4)ccc3F)c(F)c2)COC1 CHEMBL4107538 Ki 0.056 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNC[C@@H](O)C3)n2)c1 CHEMBL4111637 Ki 0.056 nM
O=C(Nc1c[nH]c2ncccc12)c1cnn2ccc(NC[C@H]3CCNC[C@H]3F)nc12 CHEMBL2387477 Ki 0.057 nM
CC(C)Cn1cc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3920836 Ki 0.057 nM
CO[C@@H]1C[C@@H](c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)OCC[C@H]1N CHEMBL4107345 Ki 0.057 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cc([C@@H]4CCCO4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4114977 Ki 0.057 nM
Cn1ncc(NC(=O)c2nc(-c3ccccn3)sc2N)c1N1CC[C@H](N)CC(F)(F)C1 CHEMBL3648703 Ki 0.058 nM
Cn1ncc(NC(=O)c2nc(-c3cc(F)ccc3F)sc2N)c1N1CC[C@@H](N)[C@@H](F)CC1 CHEMBL3648713 Ki 0.058 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@@H]2OC(=O)N[C@@H]2CC1 CHEMBL3648846 Ki 0.058 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(N)C(CO)CC1 CHEMBL3648860 Ki 0.058 nM
Cn1ncc(NC(=O)c2nc(-c3cnn(C)c3C(F)(F)F)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4106441 Ki 0.058 nM
Cn1ncc(NC(=O)c2csc(-c3cc(F)ccc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4115174 Ki 0.058 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3946970 Ki 0.058 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5CC5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3919725 IC50 0.0586 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1N1CC[C@H](N)C1 CHEMBL3905211 Ki 0.059 nM
O[C@H]1CCN(c2nc(-c3n[nH]c4cnc(-c5cccnc5)cc34)ccc2Br)C1 CHEMBL3910790 Ki 0.059 nM
COc1ccc(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c(F)c1 CHEMBL4109162 Ki 0.059 nM
CCn1cc(-c2cc3c(-c4cccc(NC5CCCC(N)C5)n4)n[nH]c3cn2)cn1 CHEMBL3909163 Ki 0.0593 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1N[C@H]1CCC[C@@H](N)C1 CHEMBL3903686 IC50 0.0598 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCC[C@H](N)C5)n4)n[nH]c3cn2)cn1 CHEMBL3634758 Ki 0.06 nM
CCOCc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691939 IC50 0.06 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3687414 IC50 0.06 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1cc(-c2ccsc2)nn1 CHEMBL3687417 IC50 0.06 nM
CCOCc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OC)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687510 IC50 0.06 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](NC(=O)OC)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687515 IC50 0.06 nM
Cc1nc2cccc3c2nc1NC/C=C\C[C@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3810121 IC50 0.06 nM
C[C@@H]1C[C@H](N)CN(c2ccncc2Nc2ncc3ccc(-c4ncccc4F)nn23)C1 CHEMBL3913540 IC50 0.06 nM
Cc1cc(-c2nc(C(=O)Nc3cnn(C)c3N3CC[C@@H](N)CC(F)(F)C3)c(N)s2)ccn1 CHEMBL3648837 Ki 0.06 nM
N[C@@H]1CCCN(c2nc(-c3n[nH]c4cnc(-c5cccnc5)cc34)ccc2Cl)C1 CHEMBL4111896 Ki 0.06 nM
COCCn1cc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3973653 Ki 0.06 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCNC(C(F)(F)F)C5)n4)n[nH]c3cn2)cn1 CHEMBL3939792 Ki 0.06 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(NC3CCNCC3)n2)n1 CHEMBL3900258 Ki 0.06 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(CO)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3892885 Ki 0.06 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CC5CC5)c(NC5(C)CC5)nc34)[nH]c21 CHEMBL4436404 IC50 0.06 nM
O=C(Nc1c[nH]c2ccc(-c3c(F)cccc3F)cc12)c1cnn2ccc(NCC3CCNCC3)nc12 CHEMBL2387472 Ki 0.061 nM
N[C@H]1CCCN(c2cncc(-c3cc4c(-c5ccccc5F)n[nH]c4cn3)n2)CC1 CHEMBL3891729 Ki 0.061 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3C(F)(F)F)sc2N)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3982938 Ki 0.061 nM
CC(C)C(=O)c1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c(F)c1 CHEMBL4112719 Ki 0.061 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCC4(CNC4)C3)n2)n1 CHEMBL3983224 Ki 0.061 nM
C[C@@H]1[C@@H](N)CCCN1c1ccncc1Nc1ncc2ccc(-c3c(F)cccc3F)nn12 CHEMBL3905194 IC50 0.062 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cnn(C)c4)cc23)nc1N1CCC[C@H](O)C1 CHEMBL3919155 Ki 0.062 nM
Cn1ncc(NC(=O)c2nc(C3=CCCC3)sc2N)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3936458 Ki 0.062 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCC(F)C(N)C5)n4)n[nH]c3cn2)cn1 CHEMBL3985979 Ki 0.063 nM
c1cc(N2CCNCC2)nc(-n2ncc3cnc(-c4cncc(C5CC5)n4)cc32)c1 CHEMBL3958785 Ki 0.063 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)sc2N)c1N1CC[C@@H](N)[C@@H](F)CC1 CHEMBL3648709 Ki 0.064 nM
CCn1cc(-c2cc3c(-c4cncc(N5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3942799 Ki 0.064 nM
Cn1ncc(NC(=O)c2csc(-c3cccc(Cl)c3F)n2)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3929314 Ki 0.064 nM
Cc1[nH]nc(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c1C CHEMBL4108293 Ki 0.064 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnn(C2CC2)c1N1CCC(N)C(F)CC1 CHEMBL3648743 Ki 0.0647 nM
C[C@H]1NC(=O)c2cc(-c3c(F)ccc4c(=O)n(C)c(NC5(C)CC5)nc34)[nH]c21 CHEMBL3941050 IC50 0.065 nM
CC[C@H]1CNCCN1c1c(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)cnn1C CHEMBL3648668 Ki 0.066 nM
CO[C@H]1CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC[C@@H]1N CHEMBL3648687 Ki 0.066 nM
CN(C)[C@@H]1CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC(F)(F)C1 CHEMBL3648726 Ki 0.066 nM
CO[C@H]1CO[C@H](c2c(NC(=O)c3csc(-c4c(F)cccc4F)n3)cnn2C)CC[C@H]1N CHEMBL4107751 Ki 0.066 nM
N[C@H]1C[C@@H](F)CN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 CHEMBL4109361 Ki 0.0662 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@H](N)[C@@H](F)CC1 CHEMBL3648681 Ki 0.067 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@H]1CC(F)[C@@H](N)CCO1 CHEMBL3895991 Ki 0.068 nM
Cc1noc(C)c1-c1nc(C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@H](F)CO2)cs1 CHEMBL4115623 Ki 0.068 nM
Cn1ncc(NC(=O)c2csc(-c3cnn(C4CC4)c3)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4111541 Ki 0.068 nM
Cc1cccc(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c1F CHEMBL4106639 Ki 0.068 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C#N)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3898989 Ki 0.068 nM
CC#Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3983351 Ki 0.068 nM
CO[C@H]1CC=C(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC[C@@H]1N CHEMBL3648794 Ki 0.069 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCC[C@H](N)CC5)n4)n[nH]c3cn2)cn1 CHEMBL3897198 Ki 0.069 nM
C[C@H](O)c1ccc(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c(F)c1F CHEMBL3920439 Ki 0.069 nM
c1cc(N2CCCNCC2)nc(-n2ncc3cnc(-c4cnn(C5CC5)c4)cc32)c1 CHEMBL3984183 Ki 0.069 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(OC3CCCC(N)C3)n2)n1 CHEMBL3924903 Ki 0.069 nM
COC1CCN(c2c(NC(=O)c3nc(-c4ccccc4F)sc3N)cnn2C)CCC1N CHEMBL3648738 Ki 0.0694 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](S(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687528 IC50 0.07 nM
CC(C)NC(=O)c1ccc(F)c(-c2ccc(N)c(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)n2)c1 CHEMBL3691981 IC50 0.07 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H](N)[C@H]1S(C)(=O)=O CHEMBL3687525 IC50 0.07 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1S(=O)(=O)CCO CHEMBL3639862 IC50 0.07 nM
Cc1nc2cccc3c2nc1NCCCC[C@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3808669 IC50 0.07 nM
N[C@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C1 CHEMBL3919646 IC50 0.07 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1CCC(N)CC(C)(O)C1 CHEMBL3648829 Ki 0.07 nM
c1cncc(-c2cc3c(-c4cccc(N5CCC(C6CCNCC6)CC5)n4)n[nH]c3cn2)c1 CHEMBL3910227 Ki 0.07 nM
N[C@@H]1CCCN(c2nccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 CHEMBL4108767 Ki 0.07 nM
CN1CCN(c2nc(-c3n[nH]c4cnc(-c5cnn(C)c5)cc34)ccc2Br)CC1 CHEMBL3898949 Ki 0.07 nM
CCn1cc(-c2cc3c(-c4cccc(N5C[C@@H](C)N[C@@H](C)C5)n4)n[nH]c3cn2)cn1 CHEMBL3956027 Ki 0.07 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1C[C@@H](N)[C@H](F)CCO1 CHEMBL4112915 Ki 0.07 nM
CC(C)n1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccc2c1=O CHEMBL3940091 IC50 0.07 nM
C[C@H]1NC(=O)c2cc(-c3c(F)ccc4c(=O)n(C5CC5)c(NC5(C)CCC5)nc34)[nH]c21 CHEMBL3944421 IC50 0.07 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCCC(N)C3)n2)n1 CHEMBL3937209 Ki 0.07 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc([C@H]3CNCCC3(F)F)n2)n1 CHEMBL4076913 Ki 0.07 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cc([C@H]4CCCO4)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL3318856 Ki 0.071 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCCC(O)C5)n4)n[nH]c3cn2)cn1 CHEMBL3916440 Ki 0.071 nM
Cn1ncc(NC(=O)c2nc(-c3c(Cl)cccc3C(F)(F)F)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4110788 Ki 0.071 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCNCC(C#N)C5)n4)n[nH]c3cn2)cn1 CHEMBL3919615 Ki 0.072 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@]12CC[C@@H](N)[C@H](CC1)O2 CHEMBL4113088 Ki 0.072 nM
Cn1ncc(NC(=O)c2csc(-c3ccccc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4111273 Ki 0.072 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNC[C@@H]3C)n2)n1 CHEMBL3949274 Ki 0.072 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCC[C@](C)(O)C5)n4)n[nH]c3cn2)cn1 CHEMBL3925349 Ki 0.0721 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3634761 Ki 0.073 nM
O[C@@H]1CCCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 CHEMBL4111020 Ki 0.073 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCC[C@@](C)(O)C5)n4)n[nH]c3cn2)cn1 CHEMBL4107869 Ki 0.073 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCC[C@@H](N)CC5)n4)n[nH]c3cn2)cn1 CHEMBL4113286 Ki 0.073 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(Cl)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3891851 Ki 0.073 nM
Cc1cncc(-c2cc3c(cnn3-c3cccc(N4CCNCC4)n3)nn2)n1 CHEMBL3970953 Ki 0.073 nM
O=C(Nc1c[nH]c2ncccc12)c1cnn2ccc(NC[C@@H]3CCNC[C@@H]3F)nc12 CHEMBL2387476 Ki 0.074 nM
c1cc(-c2n[nH]c3cnc(-c4cncs4)cc23)nc(N2CCNCC2)c1 CHEMBL3943032 Ki 0.074 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(NC5(C)CCC5)nc34)[nH]c21 CHEMBL3968854 IC50 0.074 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cnc(C)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3935018 Ki 0.074 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC[C@H](NCC2COC2)CC1 CHEMBL3648750 Ki 0.075 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cc(C(CO)CO)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4112703 Ki 0.075 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCNCC(F)C5)n4)n[nH]c3cn2)cn1 CHEMBL3915485 Ki 0.076 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cccc3F)n2)c1[C@H]1CC[C@H](N)[C@H](O)CO1 CHEMBL3914983 Ki 0.076 nM
N[C@@H]1CCC[C@H](Nc2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 CHEMBL4114921 Ki 0.077 nM
NC1CCCCN(c2cccc(-c3n[nH]c4cnc(-c5cnn(CCF)c5)cc34)n2)C1 CHEMBL3902878 Ki 0.077 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCCC(C)(O)C5)n4)n[nH]c3cn2)cn1 CHEMBL3947566 Ki 0.078 nM
COC(c1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)ccc2F)c(F)c1)C1CC1 CHEMBL4107120 Ki 0.078 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC(O)C3)n2)cn1 CHEMBL3937034 Ki 0.078 nM
CN[C@@H]1CCCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2CC(F)F)CC1 CHEMBL3648662 Ki 0.079 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnn(CC(F)F)c3N3CCCC(O)CC3)c(N)s2)c1 CHEMBL3648666 Ki 0.079 nM
CCCCc1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1N1CCC[C@H](N)C1 CHEMBL3919641 Ki 0.079 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@H]1CC[C@@H](N)C(F)CO1 CHEMBL4111307 Ki 0.079 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)C[C@@H](N)[C@H]1S(C)(=O)=O CHEMBL3687518 IC50 0.08 nM
COC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC(C)C)cc3F)n2)C[C@@H]1C CHEMBL3691933 IC50 0.08 nM
CC(C)NC(=O)c1ccc(F)c(-c2ccc(N)c(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCC#N)[C@@H](C)C3)n2)c1 CHEMBL3687521 IC50 0.08 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687485 IC50 0.08 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](S(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687522 IC50 0.08 nM
Cn1ncc(NC(=O)c2nc(-c3cccc(C#N)n3)sc2N)c1N1CC[C@@H](N)CC(F)(F)C1 CHEMBL3648834 Ki 0.08 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCC[C@H](NC)C5)n4)n[nH]c3cn2)cn1 CHEMBL3905269 Ki 0.08 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cc(C(C)(C)O)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3911392 Ki 0.08 nM
c1cc(N2CCCNCC2)nc(-n2ncc3cnc(-c4cncc(C5COC5)c4)cc32)c1 CHEMBL3939101 Ki 0.08 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC[C@H](NCC(F)F)CC1 CHEMBL4455188 Ki 0.08 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CC5(O)CC5)c(NC5(C)CC5)nc34)[nH]c21 CHEMBL4446411 IC50 0.08 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCN[C@@H](C)C5)n4)n[nH]c3cn2)cn1 CHEMBL3925846 Ki 0.081 nM
C[C@@H]1C[C@H](N)CCC(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)O1 CHEMBL4113916 Ki 0.081 nM
CCc1ccc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c1 CHEMBL4111573 Ki 0.081 nM
FC(F)(F)Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3972050 Ki 0.081 nM
N[C@@H]1CCCN(c2nc(-c3n[nH]c4cnc(-c5cccnc5)cc34)ccc2Br)C1 CHEMBL4113881 Ki 0.082 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCCCC(N)C5)n4)n[nH]c3cn2)cn1 CHEMBL3962879 Ki 0.082 nM
CCn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccc2c1=O CHEMBL3909217 IC50 0.082 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnn(CC(F)F)c1N1CCCC[C@H](N)C1 CHEMBL3648658 Ki 0.083 nM
CO[C@H]1CO[C@H](c2c(NC(=O)c3nc(-c4ccccc4C(F)(F)F)sc3N)cnn2C)CC[C@H]1N CHEMBL4112486 Ki 0.083 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3cccc(F)c3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4114975 Ki 0.083 nM
CO[C@H]1CO[C@H](c2c(NC(=O)c3nc(-c4c(F)cccc4C(F)(F)F)sc3N)cnn2C)CC[C@H]1N CHEMBL4107249 Ki 0.083 nM
CN(C)C(=O)c1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c(F)c1 CHEMBL4114435 Ki 0.083 nM
NC1CCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)CC1 CHEMBL3948473 Ki 0.0839 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@@H]2OC(=O)N[C@]2(C)CC1 CHEMBL3648858 Ki 0.084 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCNC(CO)C5)n4)n[nH]c3cn2)cn1 CHEMBL3965567 Ki 0.084 nM
COC(c1cc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c(F)c1)C1CC1 CHEMBL4113793 Ki 0.084 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCC(CN)CC5)n4)n[nH]c3cn2)cn1 CHEMBL3961362 Ki 0.085 nM
NC[C@H]1CCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 CHEMBL4112458 Ki 0.085 nM
Cn1ncc(NC(=O)c2csc(-n3ncc4ccccc43)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4108169 Ki 0.085 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)c1 CHEMBL3939394 Ki 0.085 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cncc3F)sc2N)c1N1CC[C@@H](N)[C@H](F)CC1 CHEMBL3648838 Ki 0.086 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCC(N)CC5)n4)n[nH]c3cn2)cn1 CHEMBL3980792 Ki 0.086 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1N1CCC(O)CC1 CHEMBL3939866 Ki 0.086 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnn(C4CC4)c3N3CCC(N)C(F)CC3)c(N)s2)c1 CHEMBL3648742 Ki 0.087 nM
CS(=O)(=O)CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3956440 Ki 0.087 nM
OC1CN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)CCC1F CHEMBL3975801 Ki 0.089 nM
OCC#Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3934383 Ki 0.089 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1S(C)(=O)=O CHEMBL3687447 IC50 0.09 nM
CO/N=C1\[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687426 IC50 0.09 nM
COC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H]1C CHEMBL3691959 IC50 0.09 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(F)CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1S(C)(=O)=O CHEMBL3687520 IC50 0.09 nM
C[C@H]1CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H](N)[C@H]1C#N CHEMBL3687464 IC50 0.09 nM
CCn1cc(-c2cc3c(-c4ccc(Br)c(N5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3974500 Ki 0.09 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCCC(O)CC1 CHEMBL4472966 Ki 0.09 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CC5CC5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4441708 IC50 0.09 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnn(CC(F)F)c1N1CCCC[C@@H](N)C1 CHEMBL3648659 Ki 0.091 nM
Cn1ncc(NC(=O)c2nc(-c3ncccc3F)sc2N)c1N1CC[C@H](N)[C@@H](F)CC1 CHEMBL3648711 Ki 0.091 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)sc2N)c1N1CC[C@@H](F)[C@@H](N)CC1 CHEMBL3648712 Ki 0.091 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1N1CC[C@H](O)C1 CHEMBL3921516 Ki 0.091 nM
Cc1cccc(F)c1-c1nc(C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@H](F)CO2)cs1 CHEMBL4115456 Ki 0.091 nM
Cn1cc(-c2cc3c(-c4cccc(NC5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3906211 Ki 0.092 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3C(F)F)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4110086 Ki 0.092 nM
CCn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(N)C(F)CC1 CHEMBL3648770 Ki 0.093 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCC(N)(C(F)(F)F)C5)n4)n[nH]c3cn2)cn1 CHEMBL3912940 Ki 0.093 nM
FC(F)(F)c1cncc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)c1 CHEMBL3915245 Ki 0.093 nM
CC(C)n1cc(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@@H](F)CO3)c(N)s2)cn1 CHEMBL3910710 Ki 0.093 nM
Cn1ncc(NC(=O)c2csc(-c3cc(C4CC4)ccc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4108995 Ki 0.093 nM
N[C@H]1CCC[C@@H]1Oc1cncc(-c2cc3c(cn2)cnn3-c2ccccn2)n1 CHEMBL3963170 Ki 0.094 nM
Cn1cc(-c2cc3c(-c4ccnc(N5CCC[C@H](N)C5)n4)n[nH]c3cn2)cn1 CHEMBL3904083 Ki 0.0941 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@@H]1C[C@H](O)CCO1 CHEMBL4114860 Ki 0.095 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3944062 Ki 0.095 nM
FCCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3942446 Ki 0.095 nM
CN[C@H]1CCCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC1 CHEMBL3652645 Ki 0.096 nM
Cn1cc(-c2n[nH]c3cnc(-c4cncc(N5CCC(N)CC5)n4)cc23)cn1 CHEMBL3977619 Ki 0.096 nM
NC1CCN(c2nc(-c3n[nH]c4cnc(-c5cccnc5)cc34)ccc2Cl)CC1 CHEMBL3934124 Ki 0.096 nM
CN[C@@H]1CCCN(c2c(NC(=O)c3nc(-c4cc(C)ccc4F)sc3N)cnn2CC(F)F)CC1 CHEMBL3648664 Ki 0.097 nM
N[C@@H]1CCCCN(c2cccc(-c3n[nH]c4cnc(-c5cnn(CCF)c5)cc34)n2)C1 CHEMBL4113718 Ki 0.098 nM
Cn1ncc(NC(=O)c2nc(-c3cccc(F)c3C(F)(F)F)sc2N)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3938462 Ki 0.098 nM
Cn1ncc(NC(=O)c2csc(-c3ccccc3F)n2)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3943377 Ki 0.098 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@H]1C[C@H](F)[C@@H](N)CCO1 CHEMBL3978119 Ki 0.099 nM
NC1CCN(c2cncc(-c3cc4c(-c5ccccc5F)n[nH]c4cn3)n2)CC1 CHEMBL3634779 Ki 0.1 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687502 IC50 0.1 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(F)CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691979 IC50 0.1 nM
Cc1nc2cccc3c2nc1N[C@H](C)CCC[C@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3810095 IC50 0.1 nM
C/C1=C\C[C@H]2CNC(=O)c3cc([nH]c32)-c2cccc3nc(C)c(nc23)NC1 CHEMBL3808662 IC50 0.1 nM
C[C@H]1CN(c2ccncc2Nc2ncc3ccc(-c4ccc(S(C)(=O)=O)cc4F)nn23)C[C@@H](N)[C@@H]1O CHEMBL3986154 IC50 0.1 nM
C[C@@H]1CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C[C@@H](N)[C@H]1O CHEMBL4109503 IC50 0.1 nM
NC1CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)CCC1F CHEMBL3909297 IC50 0.1 nM
C[C@@H]1C[C@H](N)CN(c2ccncc2Nc2ncc3ccc(-c4cc(C(=O)NC5CC5)ccc4F)nn23)C1 CHEMBL4110951 IC50 0.1 nM
C[C@@H]1CC[C@@H](N)CN1c1ccncc1Nc1ncc2ccc(-c3ncccc3F)nn12 CHEMBL4107310 IC50 0.1 nM
NCC1CCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)CC1 CHEMBL3923697 Ki 0.1 nM
CCn1cc(-c2cc3c(-c4ccc(C)c(N5CCC[C@@H](N)C5)n4)n[nH]c3cn2)cn1 CHEMBL4112327 Ki 0.1 nM
N[C@H]1CCC[C@@H](Nc2ccc3cccc(-c4cc5c([nH]4)CCNC5=O)c3n2)C1 CHEMBL3907732 IC50 0.1 nM
CCN(c1cnc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1)C(C)(C)C CHEMBL3901766 IC50 0.1 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)[nH]c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3934565 IC50 0.1 nM
CC(C)Nc1nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)c(F)ccc2c(=O)n1C1CC1 CHEMBL3984961 IC50 0.1 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5CC5)c(NC5(C)CC5)nc34)[nH]c21 CHEMBL3958862 IC50 0.1 nM
C[C@H]1NC(=O)c2cc(-c3c(F)ccc4c(=O)n(C)c(NC5(C)CCC5)nc34)[nH]c21 CHEMBL3896782 IC50 0.1 nM
CC(C)c1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](N)C3)n2)c1 CHEMBL3952845 Ki 0.1 nM
NC(=O)c1cc(Cl)c2c(Cl)c(C#CCCO)n([C@H]3CCCNC3)c2n1 CHEMBL4448325 Ki 0.1 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1NC(C)(C)C CHEMBL3979182 IC50 0.1 nM
CO[C@@H]1CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C2CC2)CC[C@@H]1N CHEMBL3648781 Ki 0.103 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCCC[C@H](O)C5)n4)n[nH]c3cn2)cn1 CHEMBL3891459 Ki 0.103 nM
Cn1ncc(NC(=O)c2csc(-c3ccc[nH]c3=O)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4115261 Ki 0.103 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC[C@H](NCCO)CC1 CHEMBL3648745 Ki 0.104 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@@H]1CC[C@@H](CN)O1 CHEMBL3908838 Ki 0.104 nM
Cn1ncc(NC(=O)c2csc(-c3cccc(F)c3F)n2)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3967921 Ki 0.104 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3C(F)(F)F)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4112657 Ki 0.104 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC(O)C3)n2)c1 CHEMBL3976760 Ki 0.104 nM
FC1(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)CCNCC1 CHEMBL3898951 Ki 0.105 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@@H]1CC(F)[C@H](N)CCO1 CHEMBL4107870 Ki 0.105 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1OCC(CO)CO1 CHEMBL3929517 Ki 0.105 nM
NCCOc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3960453 Ki 0.105 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCC[C@@H](O)C5)n4)n[nH]c3cn2)cn1 CHEMBL4111759 Ki 0.106 nM
c1cc(-c2n[nH]c3cnc(-c4cnn(C5CC5)c4)cc23)nc(N2CCNCC2)c1 CHEMBL3934472 Ki 0.106 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCN(C(C)=O)CC5)n4)n[nH]c3cn2)cn1 CHEMBL3900358 Ki 0.107 nM
CCn1cc(-c2cc3c(-c4cc(C#N)cc(N5CCCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3890885 Ki 0.107 nM
Cn1ncc(NC(=O)c2nc(-c3cccc(C(F)(F)F)c3F)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4112759 Ki 0.107 nM
Cn1ncc(NC(=O)c2csc(-c3ncccc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4113791 Ki 0.107 nM
C[C@H]1CN(c2cccc(-n3ncc4cnc(-c5cncc(C6COC6)c5)cc43)n2)CCN1 CHEMBL3890745 Ki 0.107 nM
COc1ccc(-n2ncc3cnc(-c4cnn(CC(F)(F)F)c4)cc32)nc1N1CCNC[C@@H](O)C1 CHEMBL4115539 Ki 0.107 nM
FCCn1cc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3902415 Ki 0.108 nM
CCn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@H](N)[C@@H](F)CC1 CHEMBL3648756 Ki 0.109 nM
C[C@@]1(N)CCCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 CHEMBL4115669 Ki 0.11 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cnn(C)c4)cc23)nc1N1CCC[C@@H](O)C1 CHEMBL4110181 Ki 0.11 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CC5(N)CC5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4468122 IC50 0.11 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cccc3F)n2)c1[C@H]1CC[C@H](N)[C@@H](O)CO1 CHEMBL3911033 Ki 0.111 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1N1CCC[C@@H](O)C1 CHEMBL4114163 Ki 0.112 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cnn(C)c4)cc23)nc1N1CCN(CCS(C)(=O)=O)C(C)(C)C1 CHEMBL3889946 Ki 0.112 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cncc3F)n2)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3956890 Ki 0.112 nM
CN1CCN(c2nc(-c3n[nH]c4cnc(-c5cccnc5)cc34)ccc2Cl)CC1 CHEMBL3971052 Ki 0.113 nM
NC[C@@H]1CCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 CHEMBL3915324 Ki 0.113 nM
COc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3917077 Ki 0.113 nM
N[C@@H]1CCCN(c2cncc(-c3cc4c(-c5ccccc5F)n[nH]c4cn3)n2)C1 CHEMBL4107874 Ki 0.114 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@H]1CC[C@H](F)[C@@H](N)CO1 CHEMBL3979941 Ki 0.114 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)ccc2N)c1N1CCCC(N)CC1 CHEMBL3652627 Ki 0.115 nM
N[C@H]1CCCN(c2nc(-c3n[nH]c4cnc(-c5cccnc5)cc34)ccc2C(F)(F)F)C1 CHEMBL3935203 Ki 0.117 nM
Cn1ncc(NC(=O)c2csc(-c3cccc4c3cnn4C)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4112100 Ki 0.117 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3C[C@@H](N)C[C@@H](F)C3)n2)n1 CHEMBL4113302 Ki 0.117 nM
OCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3919520 Ki 0.117 nM
N[C@@H]1CCN(c2nc(-c3n[nH]c4cnc(-c5cccnc5)cc34)ccc2Br)C1 CHEMBL4114322 Ki 0.118 nM
COC1(c2c(NC(=O)c3nc(-c4ncccc4F)sc3N)cnn2C)CCCCO1 CHEMBL3956102 Ki 0.118 nM
COC1(c2cc(F)c(-c3nc(C(=O)Nc4cnn(C)c4[C@@H]4CC[C@@H](N)[C@@H](F)CO4)ccc3F)c(F)c2)COC1 CHEMBL3951622 Ki 0.119 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)c1 CHEMBL3901481 Ki 0.119 nM
CCOCc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](S(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687526 IC50 0.12 nM
COC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC4CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3691954 IC50 0.12 nM
Nc1sc(-c2cc(F)ccc2F)nc1C(=O)Nc1cnn(CC(F)F)c1N1CCC[C@@H](N)CC1 CHEMBL3648684 Ki 0.12 nM
CO[C@H]1CCC(c2c(NC(=O)c3nc(-c4ccccc4F)sc3N)cnn2C)CC[C@@H]1N CHEMBL3648797 Ki 0.12 nM
N[C@H]1CCCN(c2cncc(-c3cc4c(-c5ccccc5F)n[nH]c4cn3)n2)C1 CHEMBL3900279 Ki 0.12 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CCCO)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3919616 IC50 0.12 nM
N[C@H]1CCC[C@@H]1Nc1cncc(-c2cc3c(cn2)cnn3-c2ccccn2)n1 CHEMBL3915913 Ki 0.12 nM
CC(c1cn(C)cn1)n1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccc2c1=O CHEMBL4464030 IC50 0.12 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cncc3F)sc2N)c1N1CC[C@H](N)[C@@H](F)CC1 CHEMBL3648816 Ki 0.121 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCCCC(O)C5)n4)n[nH]c3cn2)cn1 CHEMBL3933966 Ki 0.122 nM
Cn1cc(-c2cc3c(-c4cccc(N5C[C@@H](N)C[C@@H](F)C5)n4)n[nH]c3cn2)cn1 CHEMBL4114898 Ki 0.122 nM
c1cc(N2CCCNCC2)nc(-n2ncc3cnc(-c4cn[nH]c4)cc32)c1 CHEMBL3968789 Ki 0.122 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)cnc2N)c1N1CCC(N)C(F)CC1 CHEMBL3648691 Ki 0.123 nM
Cn1ncc(NC(=O)c2csc(-c3cnn(CC(C)(C)O)c3)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4110801 Ki 0.124 nM
CC(C)c1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)c1 CHEMBL3947484 Ki 0.124 nM
CO[C@H]1CCC(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)OC[C@@H]1N CHEMBL3905768 Ki 0.125 nM
COc1ncc(-n2ncc3cnc(-c4cncc(C)n4)cc32)nc1N1CCC[C@H](N)C1 CHEMBL3897912 Ki 0.125 nM
CC(=O)NC1(C)CCCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC1 CHEMBL3648776 Ki 0.126 nM
Cn1cc(-c2cc3c(-c4cccc(N5C[C@@H]6C[C@H]5CN6)n4)n[nH]c3cn2)cn1 CHEMBL3921180 Ki 0.126 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@@H]1C[C@@H](N)[C@@H](F)CCO1 CHEMBL3917660 Ki 0.126 nM
CO[C@H]1CO[C@H](c2c(NC(=O)c3nc(-c4cc(F)cc(F)c4F)sc3N)cnn2C)CC[C@H]1N CHEMBL4107816 Ki 0.127 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCC[C@](C)(O)C5)n4)n[nH]c3cn2)cn1 CHEMBL3909491 Ki 0.128 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCCC2(CNC2)C1 CHEMBL3648857 Ki 0.129 nM
Cn1ncc(NC(=O)c2csc(-c3cc[nH]n3)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4106791 Ki 0.129 nM
COC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C)cc3F)n2)C[C@@H]1C CHEMBL3691964 IC50 0.13 nM
Cc1cc(F)c(-c2nc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](C#N)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687465 IC50 0.13 nM
COC(=O)N(C)[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C)cc3F)n2)C[C@@H]1C CHEMBL3687463 IC50 0.13 nM
NCCC1CCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 CHEMBL3929385 Ki 0.13 nM
OCCn1cc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3910663 Ki 0.13 nM
CC(C)c1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@@H](N)C3)n2)c1 CHEMBL4110326 Ki 0.13 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CC5(O)CC5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4591512 IC50 0.13 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCNC[C@]2(CCO2)C1 CHEMBL3648843 Ki 0.131 nM
CCn1cc(-c2cc3c(-c4cccc(N5C[C@@H](N)C[C@@H](F)C5)n4)n[nH]c3cn2)cn1 CHEMBL4115661 Ki 0.131 nM
c1cc(-c2n[nH]c3cnc(-c4cnn(C5CCC5)c4)cc23)nc(N2CCNCC2)c1 CHEMBL3891239 Ki 0.132 nM
Cn1ncc(NC(=O)c2csc(-c3cccc(F)c3Cl)n2)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3912669 Ki 0.132 nM
CCn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(N)C(OC)CC1 CHEMBL3648784 Ki 0.133 nM
C=Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3947309 Ki 0.133 nM
Cn1ncc(NC(=O)c2csc(-c3ccncc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4109242 Ki 0.134 nM
CO[C@@H]1CO[C@H](c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC[C@H]1N CHEMBL4112852 Ki 0.135 nM
C#Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3890953 Ki 0.136 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1N1CCC[C@@H](N)C1 CHEMBL4106453 Ki 0.137 nM
CC(C)(O)Cn1cc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3959285 Ki 0.138 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCCC[C@@H](O)C5)n4)n[nH]c3cn2)cn1 CHEMBL4113346 Ki 0.139 nM
Cc1nc2cccc(-c3cc4c([nH]3)C3(CC3)NC4=O)c2nc1NC(C)(C)C CHEMBL3896124 IC50 0.139 nM
CS[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687445 IC50 0.14 nM
COCCS(=O)(=O)[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687432 IC50 0.14 nM
CC(C)C(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687416 IC50 0.14 nM
C[C@@H](O)c1ccc(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c(F)c1F CHEMBL4115247 Ki 0.14 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5CCC5)c(NC5(C)CC5)nc34)[nH]c21 CHEMBL4470271 IC50 0.14 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1CCC(N)COC1 CHEMBL3942812 Ki 0.141 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2ccc(Cl)c(N3CCC[C@H](N)C3)n2)c1 CHEMBL3908350 Ki 0.141 nM
COc1ccc(F)c(F)c1-c1nc(C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@@H](F)CO2)c(N)s1 CHEMBL3913075 Ki 0.143 nM
Cc1cnc(F)c(-c2nc(C(=O)Nc3cnn(C)c3N3CCC[C@H](N)CC3)c(N)s2)c1 CHEMBL3648806 Ki 0.144 nM
N#CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3970981 Ki 0.144 nM
CO[C@H]1CO[C@H](c2c(NC(=O)c3csc(-c4c(F)ccc(F)c4F)n3)cnn2C)CC[C@H]1N CHEMBL4107651 Ki 0.145 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC[C@H](N)[C@@H](F)C1 CHEMBL3648683 Ki 0.147 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnn(C)c3N3CC[C@@H](F)[C@@H](N)CC3)c(N)s2)c1 CHEMBL3648714 Ki 0.147 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCC[C@@H](NC)C5)n4)n[nH]c3cn2)cn1 CHEMBL4110096 Ki 0.147 nM
O[C@H]1CCC[C@@H]1Nc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3983795 Ki 0.148 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)ccc2N)c1N1CCC(N)C(F)CC1 CHEMBL3648692 Ki 0.149 nM
OC1CCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)CC1 CHEMBL3922007 Ki 0.149 nM
C[C@@H]1CC[C@H](N)CN1c1ccncc1Nc1ncc2ccc(-c3ncccc3F)nn12 CHEMBL3963283 IC50 0.15 nM
COC1CCN(c2c(NC(=O)c3nc(-c4cc(C)ccc4F)sc3N)cnn2C)CCC1N CHEMBL3648739 Ki 0.153 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCC[C@H](O)C5)n4)n[nH]c3cn2)cn1 CHEMBL3920719 Ki 0.154 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3892509 Ki 0.154 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@H]1OC[C@@](C)(CN)CO1 CHEMBL3977020 Ki 0.155 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3OC(F)(F)F)sc2N)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3976523 Ki 0.155 nM
OC1CNCCN(c2cccc(-n3ncc4cnc(-c5cncc(C6CC6)c5)cc43)n2)C1 CHEMBL3936808 Ki 0.155 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNC[C@H]3C)n2)n1 CHEMBL4112816 Ki 0.156 nM
Cn1ncc(NC(=O)c2csc(-n3cccn3)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4112316 Ki 0.157 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@H](N)C[C@H](F)C1 CHEMBL3648677 Ki 0.158 nM
C[C@H]1CNCCN1c1c(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)cnn1C CHEMBL3648678 Ki 0.158 nM
Nc1sc(-c2cc(F)ccc2F)nc1C(=O)Nc1cnn(C2CC2)c1N1CCC(N)C(F)CC1 CHEMBL3648747 Ki 0.159 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](N)C3)n2)n1 CHEMBL3935096 Ki 0.159 nM
COC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3691962 IC50 0.16 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@@H](O)[C@@H](O)CC1 CHEMBL3648830 Ki 0.16 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cnn(C)c4)cc23)nc1N1CCOCC1 CHEMBL3921569 Ki 0.16 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CC(F)(F)F)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3924828 IC50 0.16 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNC[C@H](O)C3)n2)c1 CHEMBL3956155 Ki 0.16 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CC5COC5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4472803 IC50 0.16 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3cc(F)ccc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4111468 Ki 0.161 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cc(C(O)(CO)CO)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3896751 Ki 0.162 nM
OCCOc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3961360 Ki 0.163 nM
OCCN1CCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)CC1 CHEMBL3973141 Ki 0.164 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNC(C)CC3)n2)n1 CHEMBL3895531 Ki 0.164 nM
c1cc(N2CCNCC2)nc(-n2ncc3cnc(-c4cncc(C5CC5)c4)cc32)c1 CHEMBL3980040 Ki 0.165 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnn(CC(F)F)c1N1CCCC(O)CC1 CHEMBL3648665 Ki 0.166 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCC(O)CC5)n4)n[nH]c3cn2)cn1 CHEMBL3973045 Ki 0.168 nM
COC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(F)CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3691984 IC50 0.17 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1C#N CHEMBL3687467 IC50 0.17 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1NS(C)(=O)=O CHEMBL3687431 IC50 0.17 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1OS(C)(=O)=O CHEMBL3687450 IC50 0.17 nM
Cn1ncc(NC(=O)c2csc(-c3cnn(C)c3C(F)(F)F)n2)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3963752 Ki 0.171 nM
N[C@H]1CCCN(c2cccc(-c3n[nH]c4cnc(-c5cncc(F)c5)cc34)n2)C1 CHEMBL3953052 Ki 0.172 nM
O[C@@H]1CNCCN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)C1 CHEMBL4113332 Ki 0.173 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@H]1C[C@@H](O)CCO1 CHEMBL3951554 Ki 0.174 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cccc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](O)CO1 CHEMBL4108866 Ki 0.174 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnn(CC(F)(F)F)c1N1CCCCC(N)C1 CHEMBL3648730 Ki 0.175 nM
c1cc(N2CCNCC2)nc(-n2ncc3cnc(-c4cnccn4)cc32)c1 CHEMBL3902417 Ki 0.177 nM
Cn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2c1=O CHEMBL3890346 IC50 0.178 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@@H](O)[C@H](O)CC1 CHEMBL3648850 Ki 0.179 nM
N[C@H]1CCN(c2cncc(-c3cc4c(-c5ccccc5F)n[nH]c4cn3)n2)C1 CHEMBL3903586 Ki 0.179 nM
COC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)C[C@@H]1C CHEMBL3691951 IC50 0.18 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)[nH]c(N(C)C(C)(C)C)nc34)[nH]c21 CHEMBL3962064 IC50 0.18 nM
Cn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)C3(CC3)NC4=O)cccc2c1=O CHEMBL3946152 IC50 0.18 nM
OC1CCN(c2nc(-c3n[nH]c4cnc(-c5cccnc5)cc34)ccc2Br)CC1 CHEMBL3964935 Ki 0.181 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCNC(C(F)(F)F)CC5)n4)n[nH]c3cn2)cn1 CHEMBL3915381 Ki 0.181 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)[C@H](C)NC4=O)c2nc1NC(C)(C)C CHEMBL3940707 IC50 0.181 nM
CCn1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)c1=O CHEMBL3947770 Ki 0.181 nM
COc1ccc(-n2ncc3cnc(-c4cncc(C)n4)cc32)nc1N1CCNCC(O)C1 CHEMBL3893598 Ki 0.182 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(C)CC1 CHEMBL3890727 IC50 0.184 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1NC1(C)CC1 CHEMBL3903402 IC50 0.185 nM
Cn1ncc(NC(=O)c2nc(-c3ncccc3F)sc2N)c1N1CC[C@@H](N)[C@H](F)CC1 CHEMBL3648710 Ki 0.186 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)sc2N)c1N1CCNCC2(CCO2)C1 CHEMBL3648839 Ki 0.188 nM
N[C@@H]1CCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 CHEMBL4110042 Ki 0.188 nM
Cn1ncc(NC(=O)c2nc(-c3cccc(F)c3C(F)(F)F)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4112655 Ki 0.188 nM
Fc1ccccc1-c1n[nH]c2cnc(-c3cnccc3OC[C@@H]3CCNC3)cc12 CHEMBL4113130 Ki 0.189 nM
COC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC)cc3F)n2)C[C@@H]1C CHEMBL3691975 IC50 0.19 nM
Cn1cc(-c2cc3c(-c4ccc(Br)c(N5CCOCC5)n4)n[nH]c3cn2)cn1 CHEMBL3893377 Ki 0.191 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(C)CCC1 CHEMBL3957722 IC50 0.191 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](CO)NC4=O)c2nc1NC1CC1 CHEMBL3942145 IC50 0.192 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1CCC(N)CCO1 CHEMBL3914816 Ki 0.194 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@H](C)NC4=O)c2nc1NC1(C)CC1 CHEMBL3979954 IC50 0.195 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC[C@H](N(CCO)CCO)CC1 CHEMBL3648746 Ki 0.199 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@H](O)[C@@](C)(N)CC1 CHEMBL3648805 Ki 0.199 nM
COCCn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccc2c1=O CHEMBL3947143 IC50 0.199 nM
Nc1ccc(-c2ccc3[nH]nc(-c4cncc(O[C@H]5CNCCC56CC6)n4)c3c2)c(F)c1 CHEMBL3393716 IC50 0.2 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1N=[N+]=[N-] CHEMBL3687440 IC50 0.2 nM
COC(=O)N(C)[C@@H]1[C@H](C)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H]1N CHEMBL3687456 IC50 0.2 nM
FC1(COc2cccc3ccc(-c4nnc5ccc(C6CC6)cn45)nc23)CCNCC1 CHEMBL3660075 IC50 0.2 nM
N[C@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4ccccc4F)nn23)C1 CHEMBL3922469 IC50 0.2 nM
N[C@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4ncccc4F)nn23)C1 CHEMBL3914287 IC50 0.2 nM
N[C@H]1CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)CC[C@@H]1F CHEMBL3898611 IC50 0.2 nM
N[C@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4cc(C(=O)NC5CC5)ccc4F)nn23)C1 CHEMBL3918076 IC50 0.2 nM
C[C@@H]1C[C@H](N)CN(c2ccncc2Nc2ncc3ccc(-c4ncccc4Cl)nn23)C1 CHEMBL4115280 IC50 0.2 nM
C[C@H]1CC[C@@H](N)CN1c1ccncc1Nc1ncc2ccc(-c3ncccc3F)nn12 CHEMBL3933147 IC50 0.2 nM
CN(C)c1ccc(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)cn1 CHEMBL4111835 Ki 0.2 nM
CC(C)(C)Nc1cnc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3926782 IC50 0.2 nM
CC1(Nc2cnc3cccc(-c4cc5c([nH]4)CCNC5=O)c3n2)CC1 CHEMBL3965643 IC50 0.2 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5CC5)c(NC5(C)CCC5)nc34)[nH]c21 CHEMBL3911461 IC50 0.2 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(N[C@H]5CCC[C@@H](N)C5)nc34)[nH]c21 CHEMBL3918273 IC50 0.2 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC[C@H](NCC(F)(F)F)CC1 CHEMBL4449930 Ki 0.2 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCCNCC1 CHEMBL4458081 Ki 0.2 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(NC5(C)CC5)nc34)[nH]c21 CHEMBL3950704 IC50 0.2 nM
Cc1nc2ccc(F)c(-c3cc4c(=O)[nH]ccc4[nH]3)c2nc1NC(C)(C)C CHEMBL3896195 IC50 0.2 nM
Cn1ncc(NC(=O)c2nc(-c3ccccn3)sc2N)c1N1CCNCC(F)(F)C1 CHEMBL3648688 Ki 0.206 nM
N[C@@H]1CCCN(c2cccc(-c3n[nH]c4cnc(-c5cncc(F)c5)cc34)n2)C1 CHEMBL4111497 Ki 0.206 nM
COC1(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CCCCO1 CHEMBL3939838 Ki 0.209 nM
CO/N=C1/[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687425 IC50 0.21 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1[S@@+](C)[O-] CHEMBL3984944 IC50 0.21 nM
Cn1ncc(NC(=O)c2csc(-c3cnc4cccnc4c3)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4108834 Ki 0.21 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C(C)(C)C)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4436502 IC50 0.21 nM
CC(C)n1cc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3918444 Ki 0.213 nM
c1cc(N2CCCNCC2)nc(-n2ncc3cnc(-c4cnn(C5CCC5)c4)cc32)c1 CHEMBL3944757 Ki 0.213 nM
OCCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3980111 Ki 0.215 nM
Cc1ccc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3938860 Ki 0.217 nM
Cc1c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)cnn1C CHEMBL4109468 Ki 0.218 nM
CO[C@H]1CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C2CC2)CC[C@@H]1N CHEMBL3648769 Ki 0.219 nM
Cn1cc(-c2cc3c(-c4cccc(C5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3634768 Ki 0.22 nM
COC(=O)N(C)[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687470 IC50 0.22 nM
NC(=O)C1(N)CCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)CC1 CHEMBL3908723 Ki 0.22 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1N1CC[C@@H](O)C1 CHEMBL4115619 Ki 0.22 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cccc3Cl)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4115305 Ki 0.22 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCCN(CCN)CC1 CHEMBL3648788 Ki 0.222 nM
CCn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@H](N)[C@H](OC)CC1 CHEMBL3648774 Ki 0.223 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC4(CCCN4)CC3)n2)n1 CHEMBL3981915 Ki 0.223 nM
OCC(O)c1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3933868 Ki 0.224 nM
Cc1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)sn1 CHEMBL3985111 Ki 0.225 nM
FC(F)c1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3957997 Ki 0.229 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)/C1=N\O CHEMBL3687419 IC50 0.24 nM
CC(C)NC(=O)c1ccc(F)c(-c2ccc(N)c(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCS(C)(=O)=O)[C@@H](C)C3)n2)c1 CHEMBL3687537 IC50 0.24 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687460 IC50 0.24 nM
C/N=C(\C(C=N)NC(=O)c1nc(-c2ccccc2F)sc1N)N1CC[C@@H](N)[C@H](F)CC1 CHEMBL4114760 Ki 0.24 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC(N)CC3)n2)n1 CHEMBL3966696 Ki 0.243 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)ccc2N)c1N1CCC[C@@H](N)C1 CHEMBL3652625 Ki 0.246 nM
CCn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@H](OC)[C@@H](N)CC1 CHEMBL3648768 Ki 0.247 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@@H]1C[C@H](N)CCO1 CHEMBL4108158 Ki 0.248 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)[C@H](C)NC4=O)c2nc1NC1(C)CC1 CHEMBL3943763 IC50 0.249 nM
Cn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)CNC4=O)cccc2c1=O CHEMBL3897988 IC50 0.249 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCCN(C2CNC2)CC1 CHEMBL3648766 Ki 0.25 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCNCC2(CCO2)C1 CHEMBL3648840 Ki 0.251 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1CC[C@@H](N)[C@@H](F)CC1 CHEMBL3648775 Ki 0.252 nM
Cn1ncc(NC(=O)c2nc(-c3cc(F)ccc3F)sc2N)c1N1CC[C@@H](F)[C@@H](N)CC1 CHEMBL3648708 Ki 0.253 nM
Cn1cc(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@@H](F)CO3)cs2)c(C2CC2)n1 CHEMBL3892639 Ki 0.253 nM
Cc1ccc(-n2ncc3cnc(-c4cnn(CC(F)(F)F)c4)cc32)nc1N1CCNC[C@H](O)C1 CHEMBL3942104 Ki 0.253 nM
Cn1ncc(NC(=O)c2csc(-c3cc(F)cc(F)c3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4108053 Ki 0.255 nM
Cc1nc2cccc(-c3[nH]c4c(c3Cl)C(=O)N[C@@H]4C)c2nc1NC1(C)CC1 CHEMBL3933719 IC50 0.255 nM
COC1(c2cccc(-n3ncc4cnc(-c5cncc(C)n5)cc43)n2)CCCNC1 CHEMBL3955604 Ki 0.256 nM
COC1(CN)CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC1 CHEMBL3648831 Ki 0.257 nM
NCCCCNc1cccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)n1 CHEMBL3949697 Ki 0.257 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1NCC(F)F CHEMBL3937161 IC50 0.258 nM
Cn1cc(-c2cc3c(-c4ccc(Br)c(N5CCN(CCS(C)(=O)=O)C(C)(C)C5)n4)n[nH]c3cn2)cn1 CHEMBL3982513 Ki 0.259 nM
CCC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)c(F)ccc2nc1C CHEMBL3897606 IC50 0.259 nM
C[C@H]1CCN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C[C@H]1N CHEMBL3902228 IC50 0.26 nM
OCCN1CCCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)CC1 CHEMBL3937665 Ki 0.26 nM
O[C@@H]1CCCN(c2nc(-c3n[nH]c4cnc(-c5cccnc5)cc34)ccc2Br)C1 CHEMBL4110399 Ki 0.261 nM
c1cncc(-c2cc3c(-c4cccc(N5CCOCC5)n4)n[nH]c3cn2)c1 CHEMBL3930859 Ki 0.262 nM
N[C@H]1CCCN(c2cncc(-c3cc4c(-c5ccccc5F)n[nH]c4cn3)c2)C1 CHEMBL3957209 Ki 0.264 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCC[C@@](C)(O)C5)n4)n[nH]c3cn2)cn1 CHEMBL4115144 Ki 0.265 nM
COC1CCN(c2c(NC(=O)c3nc(-c4ncccc4F)sc3N)cnn2C)CCC1N CHEMBL3648737 Ki 0.266 nM
Nc1ncccc1-c1cc2c(-c3cccc(N4CCNCC4)n3)n[nH]c2cn1 CHEMBL3900915 Ki 0.267 nM
Cn1ncc(NC(=O)c2csc(-n3cc4c(n3)CCCC4)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4114572 Ki 0.267 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC[C@@H](C(F)(F)F)C1 CHEMBL3648690 Ki 0.268 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCN(C)CC5)n4)n[nH]c3cn2)cn1 CHEMBL3956461 Ki 0.268 nM
Cn1cc(-c2cc3c(-c4cccc(O[C@@H]5CCCNC5)n4)n[nH]c3cn2)cn1 CHEMBL3634755 Ki 0.27 nM
N[C@H]1CCN(c2cncc(-c3cc4c(-c5ccccc5F)n[nH]c4cn3)c2)C1 CHEMBL3923325 Ki 0.27 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1CC[C@H](N)[C@H](F)CO1 CHEMBL4107716 Ki 0.27 nM
CCc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)C CHEMBL3914535 IC50 0.271 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)cnc2N)c1N1CCC[C@H](N)C1 CHEMBL3652630 Ki 0.274 nM
Cn1ncc(NC(=O)c2csc(-c3cccc(F)c3Cl)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4114091 Ki 0.274 nM
c1ccc(-n2ncc3cnc(-c4cncc(NC5CNC5)n4)cc32)nc1 CHEMBL3985665 Ki 0.279 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ncc2N)C[C@@H]1C CHEMBL3687489 IC50 0.28 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1C#N CHEMBL3687478 IC50 0.28 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2nc(-c3cc(C(=O)NC(C)C)ccc3F)ccc2N)C[C@@H]1C CHEMBL3639908 IC50 0.28 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1N[C@H]1CCC[C@@H](NC(=O)[C@H](N)CO)C1 CHEMBL3910446 IC50 0.28 nM
COc1ccc2c(c1CN1CCNCC1)O/C(=C\c1c[nH]c3nc(F)ccc13)C2=O CHEMBL4083975 IC50 0.28 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)cnc2N)c1N1CCC(N)CC1 CHEMBL3652633 Ki 0.281 nM
Cn1cc(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@@H](F)CO3)cs2)c(C(F)(F)F)n1 CHEMBL3925116 Ki 0.281 nM
Cc1nn(C)cc1-c1nc(C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@H](F)CO2)cs1 CHEMBL4106839 Ki 0.283 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3C(F)(F)F)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4111768 Ki 0.283 nM
NC(=O)Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3940227 Ki 0.283 nM
Fc1cncc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)c1 CHEMBL3954344 Ki 0.284 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5CCOCC5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3926620 IC50 0.287 nM
CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1N CHEMBL3943301 IC50 0.289 nM
N[C@@H]1CN(c2ccncc2Nc2ncc3ccc(-c4ncccc4F)nn23)C[C@H](N)[C@H]1O CHEMBL3904539 IC50 0.29 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3907004 Ki 0.29 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5(C)CC5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4456165 IC50 0.29 nM
N=CC(NC(=O)c1nc(-c2cc(F)ccc2F)sc1N)/C(=N\CC(F)F)N1CCCC(O)CC1 CHEMBL4114805 Ki 0.292 nM
Cc1nc2cccc(-c3cc4c([nH]3)C3(CC3)NC4=O)c2nc1NC1CC1 CHEMBL3924143 IC50 0.293 nM
OC1CNCCN(c2cccc(-n3ncc4cnc(-c5cncc(C6COC6)c5)cc43)n2)C1 CHEMBL3908853 Ki 0.294 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC[C@H](NCC2(C)COC2)CC1 CHEMBL3648744 Ki 0.295 nM
NCC1CCCCN1c1cccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)n1 CHEMBL3895900 Ki 0.296 nM
Cn1cc(-c2cc3c(-c4cccc(NCCc5c[nH]cn5)n4)n[nH]c3cn2)cn1 CHEMBL3900487 Ki 0.297 nM
CS(=O)(=O)Nc1ccc(-c2ccc3[nH]nc(-c4cncc(O[C@H]5CNCCC56CC6)n4)c3c2)c(F)c1 CHEMBL3393720 IC50 0.3 nM
NCCNc1cccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)n1 CHEMBL3634780 Ki 0.3 nM
COC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4COC4)cc3F)n2)C[C@@H]1C CHEMBL3691966 IC50 0.3 nM
Cc1nc2cccc3c2nc1NC[C@@H](C)CC[C@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3809565 IC50 0.3 nM
Cc1nc2cccc3c2nc1N[C@H](C)/C=C\C[C@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3809691 IC50 0.3 nM
Cc1nc2cccc3c2nc1N[C@H](C)/C=C/C[C@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3808887 IC50 0.3 nM
C[C@H]1CN(c2ccncc2Nc2ncc3ccc(-c4nccs4)nn23)C[C@@H](N)[C@@H]1O CHEMBL3936992 IC50 0.3 nM
C[C@@H]1C[C@H](N)CN(c2ccncc2Nc2ncc3ccc(-c4nccs4)nn23)C1 CHEMBL4109688 IC50 0.3 nM
C[C@@H]1C[C@H](N)CN(c2ccncc2Nc2ncc3ccc(-c4ccccn4)nn23)C1 CHEMBL4109355 IC50 0.3 nM
C[C@H]1CN(c2ccncc2Nc2ncc3ccc(-c4ncccc4F)nn23)C[C@@H](N)[C@@H]1O CHEMBL3942827 IC50 0.3 nM
C[C@@H]1[C@@H](N)CCCN1c1ccncc1Nc1ncc2ccc(-c3ncccc3F)nn12 CHEMBL4115235 IC50 0.3 nM
C[C@@H]1CCN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C[C@@H]1N CHEMBL4107702 IC50 0.3 nM
c1cncc(-c2cc3c(-c4cnn(C5CCNCC5)c4)n[nH]c3cn2)c1 CHEMBL3943201 Ki 0.3 nM
CCN(c1cccnc1)c1ccc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3971351 IC50 0.3 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Nc5cccnc5)nc34)cc21 CHEMBL3937054 IC50 0.3 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@@H]1CCC[C@H](N)C1 CHEMBL3958307 IC50 0.3 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@@H]1CC[C@H](N)C1 CHEMBL3966072 IC50 0.3 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(C)CC1 CHEMBL3957954 IC50 0.3 nM
CC1(C)CCCN1c1cnc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3956736 IC50 0.3 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5CCC5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3904050 IC50 0.3 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)C CHEMBL4587596 IC50 0.3 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3979678 IC50 0.3 nM
N[C@@H]1CCN(c2cncc(-c3cc4c(-c5ccccc5F)n[nH]c4cn3)n2)C1 CHEMBL4107949 Ki 0.302 nM
Cc1nc2nccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)C CHEMBL3919994 IC50 0.303 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](NC(=O)OC)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687516 IC50 0.31 nM
CC(C)NC(=O)c1ccc(F)c(-c2ccc(N)c(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)n2)c1 CHEMBL3691980 IC50 0.31 nM
COc1ccc(-n2ncc3cnc(-c4cnn(CC(F)(F)F)c4)cc32)nc1N1CCNCC(O)C1 CHEMBL3981028 Ki 0.31 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCN(C6COC6)CC5)n4)n[nH]c3cn2)cn1 CHEMBL3957858 Ki 0.311 nM
c1cncc(-c2cc3c(-c4ccn(C5CCNCC5)n4)n[nH]c3cn2)c1 CHEMBL3949010 Ki 0.313 nM
Cc1c(-c2nc(C(=O)Nc3cnn(C)c3N3CC[C@@H](N)[C@H](F)CC3)c(N)s2)cnn1C CHEMBL3648810 Ki 0.315 nM
Cn1cc(-c2cc3c(-c4ccc(Br)c(N5CCC[C@@H](O)C5)n4)n[nH]c3cn2)cn1 CHEMBL4110400 Ki 0.316 nM
O=C1CN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)CCCN1 CHEMBL3929791 Ki 0.322 nM
COCCn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)CNC4=O)cccc2c1=O CHEMBL3919362 IC50 0.325 nM
Cc1nc2cccc(-c3cc4c([nH]3)C(CO)NC4=O)c2nc1NC1CC1 CHEMBL3905144 IC50 0.331 nM
Cn1cc(-c2cc3c(-c4ccc(Br)c(N5CCC[C@H](O)C5)n4)n[nH]c3cn2)cn1 CHEMBL3944848 Ki 0.333 nM
Cc1nc2cccc(-c3cc4c([nH]3)C3(CC3)NC4=O)c2nc1NC1(C)CC1 CHEMBL3909785 IC50 0.334 nM
Fc1ccccc1-c1n[nH]c2cnc(-c3cnccc3O[C@H]3CCCNC3)cc12 CHEMBL3911749 Ki 0.342 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)ccc2N)c1N1CCC[C@H](CN)C1 CHEMBL3652636 Ki 0.343 nM
Cc1nc2cccc(-c3cc4c([nH]3)CNC4=O)c2nc1NC1CC1 CHEMBL3903837 IC50 0.345 nM
CCn1ncc(NC(=O)c2nc(-c3ccccc3F)sc2N)c1N1CCC(N)C(F)CC1 CHEMBL3648772 Ki 0.346 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1C[C@@H](N)C1 CHEMBL3966363 IC50 0.347 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCN[C@@H](C)C3)n2)cn1 CHEMBL3968206 Ki 0.349 nM
CCOC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687421 IC50 0.35 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(Cc5cn(C)cn5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4563904 IC50 0.35 nM
O=C1CN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)CCN1 CHEMBL3901155 Ki 0.351 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@H]1CCC(F)[C@@H](N)CO1 CHEMBL3927346 Ki 0.351 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCCC(C(F)(F)F)C1 CHEMBL3648702 Ki 0.353 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@@H]2NC(=O)O[C@@H]2CC1 CHEMBL3648848 Ki 0.353 nM
CNC(=O)C1(N)CCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)CC1 CHEMBL3914130 Ki 0.353 nM
Fc1ccccc1-c1n[nH]c2cnc(-c3cnccc3OCC3CCCNC3)cc12 CHEMBL3928742 Ki 0.354 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1C[C@H](N)[C@@H](F)CCO1 CHEMBL3912067 Ki 0.358 nM
COCC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687415 IC50 0.36 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C[C@H]5CCCO5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4461181 IC50 0.36 nM
COC1CCC2(c3c(NC(=O)c4nc(-c5ccccc5F)sc4N)cnn3C)CCC1N2 CHEMBL3648804 Ki 0.362 nM
CC(C)(C)n1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3953482 Ki 0.362 nM
Cn1cc(-c2cc3c(-c4ccnc(N5CCCCC5)n4)n[nH]c3cn2)cn1 CHEMBL3980649 Ki 0.366 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)ccc2N)c1N1CCC[C@H](N)CC1 CHEMBL3652640 Ki 0.368 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCOCC5)n4)n[nH]c3cn2)cn1 CHEMBL3898418 Ki 0.368 nM
COC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687423 IC50 0.37 nM
CC(C)(C)n1cc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3908523 Ki 0.376 nM
Fc1ccccc1-c1n[nH]c2cnc(-c3cnccc3OCCC3CCNCC3)cc12 CHEMBL3915982 Ki 0.379 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)C1=O CHEMBL3687424 IC50 0.38 nM
CCOCc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](NC(=O)OC)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691985 IC50 0.38 nM
N[C@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4ccc(F)cc4F)nn23)C1 CHEMBL3931386 IC50 0.38 nM
Cn1ncc(NC(=O)c2nc(-c3ccncc3F)sc2N)c1N1CC[C@H](N)[C@@H](F)CC1 CHEMBL3648803 Ki 0.38 nM
Cc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnn(C)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4110892 Ki 0.382 nM
COC1CCN(c2c(NC(=O)c3nc(-c4cc(F)ccc4F)sc3N)cnn2C)CCC1N CHEMBL3648740 Ki 0.384 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC4(CNC4)C3)n2)n1 CHEMBL3907320 Ki 0.385 nM
FC(F)(F)Cn1cc(-c2cc3c(cn2)cnn3-c2cncc(N3CCCNCC3)n2)cn1 CHEMBL3900834 Ki 0.386 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCC[C@@H](N)C5)c4)n[nH]c3cn2)cn1 CHEMBL3634759 Ki 0.387 nM
Cn1cc(-c2cc3c(-c4cnn(CC(C)(C)O)c4)n[nH]c3cn2)cn1 CHEMBL3941916 Ki 0.389 nM
CCn1cc(-c2cc3c(-c4nc(N5CCC[C@H](N)C5)ccc4Cl)n[nH]c3cn2)cn1 CHEMBL3930783 Ki 0.389 nM
CC(=O)Nc1ccc(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)cn1 CHEMBL4113280 Ki 0.389 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1OP(C)(C)=O CHEMBL3687449 IC50 0.39 nM
C[C@H]1C[C@H](N)CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C1 CHEMBL3897323 IC50 0.39 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC2(CCNC2=O)CC1 CHEMBL3648764 Ki 0.391 nM
N[C@H]1CCC[C@H](Nc2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 CHEMBL3903896 Ki 0.397 nM
Oc1ccc(-c2ccc3[nH]nc(-c4cncc(O[C@H]5CNCCC56CC6)n4)c3c2)c(F)c1 CHEMBL3393717 IC50 0.4 nM
Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(O[C@H]4CNCCC45CC5)n3)c2c1 CHEMBL3393706 IC50 0.4 nM
CC(C)NC(=O)c1ccc(F)c(-c2ccc(N)c(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](S(C)(=O)=O)[C@@H](C)C3)n2)c1 CHEMBL3687519 IC50 0.4 nM
CC(C)OC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687422 IC50 0.4 nM
C/C1=C/C[C@H]2CNC(=O)c3cc([nH]c32)-c2cccc3nc(C)c(nc23)NC1 CHEMBL3809940 IC50 0.4 nM
Cc1nc2cccc3c2nc1NCCCC[C@@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3808942 IC50 0.4 nM
Fc1cc(OC2CCNCCC2F)c2nc(-c3nnc4ccccn34)ccc2c1 CHEMBL3660085 IC50 0.4 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(C)CCCC1 CHEMBL3956884 IC50 0.4 nM
CC1(C)CCN1c1cnc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3985959 IC50 0.4 nM
Cn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](CCO)NC4=O)cccc2c1=O CHEMBL3933742 IC50 0.4 nM
Cc1cncc(-c2ccc3cnn(-c4cccc(N5CCCNCC5)n4)c3c2)n1 CHEMBL4097308 Ki 0.4 nM
COCCC#Cc1c(Cl)c2c(Cl)cc(C(N)=O)nc2n1[C@H]1CCCNC1 CHEMBL4540910 Ki 0.4 nM
N[C@H]1CCCN(c2c(/C=C3\SC(=O)NC3=O)cccc2-c2ccccc2)C1 CHEMBL4793492 IC50 0.4 nM
FC(F)(F)Cn1cc(-c2cc3c(cn2)cnn3-c2ccnc(N3CCCNCC3)n2)cn1 CHEMBL3939262 Ki 0.402 nM
N[C@@H]1CCCN(c2ccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)cn2)C1 CHEMBL4111884 Ki 0.404 nM
CCn1cc(-c2cc3c(-c4cccc(N5C[C@H]6CNC[C@H]6C5)n4)n[nH]c3cn2)cn1 CHEMBL3950124 Ki 0.404 nM
FC(F)(F)CNc1nnc(-c2ccc3[nH]cc(-c4nccc(C5CC5)n4)c3c2)o1 CHEMBL3940389 IC50 0.407 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1=CCCCO1 CHEMBL3936435 Ki 0.408 nM
CNc1cccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)n1 CHEMBL3889536 Ki 0.409 nM
COc1ccc2c(c1CN1CCNCC1)O/C(=C\c1c[nH]c3nc(Cl)ccc13)C2=O CHEMBL4062256 IC50 0.41 nM
O[C@@H]1CCN(c2nc(-c3n[nH]c4cnc(-c5cccnc5)cc34)ccc2Br)C1 CHEMBL4115192 Ki 0.412 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](CO)NC4=O)c2nc1NC1(C)CC1 CHEMBL3920600 IC50 0.414 nM
c1cncc(-c2cc3c(-c4cccc(N5CCCCC5)n4)n[nH]c3cn2)c1 CHEMBL3941606 Ki 0.415 nM
FC(F)Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3916902 Ki 0.416 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](O)C3)n2)n1 CHEMBL3906421 Ki 0.419 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCCN(C(=O)CN)CC1 CHEMBL3648787 Ki 0.421 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1CCCCO1 CHEMBL3908398 Ki 0.424 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1CC[C@@H](O)[C@@H](O)CO1 CHEMBL4106553 Ki 0.425 nM
Cn1cc(-c2cc3c(-c4cccc(NCC5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3957883 Ki 0.426 nM
Cc1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)sn1 CHEMBL3915323 Ki 0.426 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3C[C@@H](N)C[C@H](F)C3)n2)n1 CHEMBL3975198 Ki 0.428 nM
CN[C@@H]1CCCN(c2c(NC(=O)c3nc(-c4cc(F)ccc4F)sc3N)cnn2CC(F)F)CC1 CHEMBL3648663 Ki 0.43 nM
CNc1cccc(-n2ncc3cnc(-c4cncc(C)n4)cc32)n1 CHEMBL3931274 Ki 0.43 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C(F)(F)F)c(N3CCNCC(O)C3)n2)n1 CHEMBL3934315 Ki 0.433 nM
CC(C)(C)Nc1ccc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3897826 IC50 0.434 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCNCC(CO)C1 CHEMBL3648761 Ki 0.439 nM
CC1C(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)OCC(C)(O)C1N CHEMBL3956569 Ki 0.441 nM
c1cncc(-c2cc3c(-c4cncc(NC5CCNCC5)c4)n[nH]c3cn2)c1 CHEMBL3914452 Ki 0.443 nM
Cc1cnc(C)c(-c2nc(C(=O)Nc3cnn(C)c3N3CC[C@@H](N)[C@H](F)CC3)c(N)s2)c1 CHEMBL3648821 Ki 0.446 nM
Cn1ncc(NC(=O)c2csc(-c3cccc(OCc4ccccc4)c3)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4107422 Ki 0.447 nM
FC1(COc2cccc3ccc(-c4nnc5ccc(-c6ccccc6)cn45)nc23)CCNCC1 CHEMBL3660077 IC50 0.45 nM
Cn1ncc(NC(=O)c2nc(C3CCCC3)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4113481 Ki 0.453 nM
Cc1nc2cccc(-c3[nH]c4c(c3Cl)C(=O)NCC4)c2nc1NC(C)(C)C CHEMBL3971342 IC50 0.455 nM
C[C@H]1O[C@@H](c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC(F)(F)[C@@]1(C)N CHEMBL4113842 Ki 0.456 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1N1CC(N2CCNC(=O)C2)C1 CHEMBL3900068 Ki 0.46 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1CCC(N)CC1 CHEMBL3652648 Ki 0.462 nM
Cn1ncc(NC(=O)c2nc(-c3ncccc3F)sc2N)c1N1CC[C@@H](F)[C@@H](N)CC1 CHEMBL3648783 Ki 0.462 nM
Cc1nc2cccc(-c3cc4c([nH]3)CNC4=O)c2nc1NC1(C)CC1 CHEMBL3957073 IC50 0.463 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1CC(F)C(N)CCO1 CHEMBL3928394 Ki 0.469 nM
N[C@H]1CC[C@H](Nc2cncc(-c3cccc(/C=C4\SC(=O)NC4=O)c3)n2)CC1 CHEMBL2032375 IC50 0.47 nM
CC[C@@H]1CNCCN1/C(=N/C)C(C=N)NC(=O)c1nc(-c2c(F)cccc2F)sc1N CHEMBL4114797 Ki 0.476 nM
CO[C@H]1COC(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC[C@@H]1N CHEMBL3895788 Ki 0.476 nM
c1cc(N2CCNCC2)nc(-n2ncc3cnc(-c4cncs4)cc32)c1 CHEMBL3953990 Ki 0.476 nM
Cc1nn(C)cc1-c1nc(C(=O)Nc2cnn(C)c2N2CC[C@@H](N)[C@H](F)CC2)c(N)s1 CHEMBL3648814 Ki 0.477 nM
c1cc(N2CCNCC2)nc(-n2ncc3cnc(-c4cncc(C5COC5)c4)cc32)c1 CHEMBL3965741 Ki 0.479 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1CCCCC(F)(F)C1 CHEMBL3648767 Ki 0.483 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1=CCOCC1 CHEMBL3962986 Ki 0.485 nM
c1ccc(COc2cncc(-c3cc4c(cn3)cnn4-c3cccc(N4CCNCC4)n3)n2)cc1 CHEMBL3972453 Ki 0.494 nM
CC(=O)O[C@H]1CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC[C@H]1N CHEMBL3648847 Ki 0.498 nM
NC(=O)c1ccc(-c2ccc3[nH]nc(-c4cncc(O[C@H]5CNCCC56CC6)n4)c3c2)c(F)c1 CHEMBL3393718 IC50 0.5 nM
Cc1nc2cccc3c2nc1NC[C@H](C)CC[C@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3809377 IC50 0.5 nM
Fc1cc(OCC2(F)CCNCC2)c2nc(-c3nnc4ccccn34)ccc2c1 CHEMBL3660096 IC50 0.5 nM
C[C@H]1[C@H](N)CCCN1c1ccncc1Nc1ncc2ccc(-c3c(F)cccc3F)nn12 CHEMBL3900795 IC50 0.5 nM
CC1CNC(=O)c2cc(-c3cccc4ccc(Nc5ccccc5)nc34)[nH]c21 CHEMBL3933369 IC50 0.5 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1C[C@H](N)C1 CHEMBL3928595 IC50 0.5 nM
Cc1cncc(-c2cc3c(ccn3-c3cccc(N4CCCNCC4)n3)cn2)n1 CHEMBL4070117 Ki 0.5 nM
Cc1cncc(-c2cn3c(-c4cccc(N5CCCNCC5)n4)ncc3cn2)n1 CHEMBL4061456 Ki 0.5 nM
Cc1nc2cccc(-c3[nH]c4c(c3Cl)C(=O)N[C@@H]4C)c2nc1NC(C)(C)C CHEMBL3932879 IC50 0.5 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1N[C@H]1CCC[C@@H](NCC(F)(F)F)C1 CHEMBL3913446 IC50 0.501 nM
Cn1cc(-c2cc3c(-c4cccc(-c5cnn(C)c5)n4)n[nH]c3cn2)cn1 CHEMBL3952046 Ki 0.502 nM
CC[C@@H]1CC(N)CC[C@H](c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)O1 CHEMBL4109168 Ki 0.502 nM
N[C@@H]1CCCN(c2cccc(-n3ncc4cnc(-c5cncs5)cc43)n2)C1 CHEMBL4106584 Ki 0.504 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@H](CN)C1 CHEMBL3652637 Ki 0.506 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)CNC4=O)c2nc1NC(C)(C)C CHEMBL3944136 IC50 0.508 nM
C[C@H]1[C@@H](N)CCCN1c1ccncc1Nc1ncc2ccc(-c3c(F)cccc3F)nn12 CHEMBL3956489 IC50 0.51 nM
Cc1nc2cccc(-c3cc4c([nH]3)C(CCO)NC4=O)c2nc1NC(C)(C)C CHEMBL3955880 IC50 0.51 nM
N[C@@H]1CCN(c2cncc(-c3cc4c(-c5ccccc5F)n[nH]c4cn3)c2)C1 CHEMBL4106476 Ki 0.511 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@H]1OC[C@@](C)(CO)CO1 CHEMBL3986706 Ki 0.514 nM
NC1CN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)C1 CHEMBL3943778 Ki 0.514 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(C3(F)CCCNC3)n2)n1 CHEMBL3909947 Ki 0.514 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(C3CCNCC3)n2)n1 CHEMBL3931279 Ki 0.517 nM
N[C@H]1CCCN(c2cccc(-c3n[nH]c4cnc(-n5ccnc5)cc34)n2)C1 CHEMBL3901903 Ki 0.523 nM
Cn1cc(-c2cc3c(-c4ccc(Br)c(N5CC(N6CCNC(=O)C6)C5)n4)n[nH]c3cn2)cn1 CHEMBL3945080 Ki 0.527 nM
CC(C)n1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3929264 Ki 0.532 nM
Cn1ncc(NC(=O)c2csc(-c3cccc(-c4cccc(Cl)c4F)c3F)n2)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3944114 Ki 0.533 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NCC1(C)CC1 CHEMBL3906357 IC50 0.534 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3691918 IC50 0.54 nM
C[C@@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3913164 IC50 0.548 nM
CC(C)(CN)COc1cc(F)cc2ccc(-c3nnc4ccccn34)nc12 CHEMBL3660041 IC50 0.55 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C[C@@H]5CN(C)CCO5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4476513 IC50 0.55 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(OC5(C)CC5)nc34)[nH]c21 CHEMBL3983621 IC50 0.554 nM
N[C@H]1CCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1=O CHEMBL3909060 Ki 0.556 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1OP(C)(C)=O CHEMBL3687448 IC50 0.56 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CC(C)(C)N)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4445845 IC50 0.56 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)C3(CC3)NC4=O)c2nc1NC(C)(C)C CHEMBL3974455 IC50 0.562 nM
Fc1ccccc1-c1n[nH]c2cnc(-c3cnccc3OC3CCNCC3)cc12 CHEMBL3969949 Ki 0.567 nM
Cn1ncc(NC(=O)c2nc(-c3ccccn3)sc2N)c1N1CC[C@H](N)[C@@H](F)CC1 CHEMBL3648705 Ki 0.568 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1OCCS(C)(=O)=O CHEMBL3691917 IC50 0.57 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3cccc(F)c3Cl)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4113681 Ki 0.57 nM
Cn1cc(-c2cc3c(-c4ccnc(C5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3898497 Ki 0.571 nM
NC1CCCN(c2cncc(-c3cc4c(-c5ccccc5F)n[nH]c4cn3)c2)CC1 CHEMBL3895408 Ki 0.574 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNC(C)(C)C3)n2)cn1 CHEMBL3938583 Ki 0.58 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCOCC5)n4)n[nH]c3cn2)cn1 CHEMBL3915064 Ki 0.581 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1[S+](C)[O-] CHEMBL3687446 IC50 0.59 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@H]1CC[C@H](N)[C@@H](F)CO1 CHEMBL3895127 Ki 0.595 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccc(OCCCN)cc4)cc32)c(=O)[nH]1 CHEMBL576388 Ki 0.6 nM
Cc1nc2cccc3c2nc1N[C@@H](C)/C=C/C[C@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3809986 IC50 0.6 nM
CCC1CNC(=O)c2cc(-c3cccc4cc(C)c(Nc5ccccc5)nc34)[nH]c21 CHEMBL3889660 IC50 0.6 nM
N[C@@H]1CCC[C@@H](Nc2ccc3cccc(-c4cc5c([nH]4)CCNC5=O)c3n2)C1 CHEMBL3935691 IC50 0.6 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CCNCC1 CHEMBL3901085 IC50 0.6 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@@H]1CCCNC1 CHEMBL3926862 IC50 0.6 nM
CN(c1cnc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1)C(C)(C)C CHEMBL3985398 IC50 0.6 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cccc3F)n2)c1N1CCC[C@H](N)CC1 CHEMBL4449080 Ki 0.6 nM
CC(O)CC#Cc1c(Cl)c2c(Cl)cc(C(N)=O)nc2n1[C@H]1CCCNC1 CHEMBL4588948 Ki 0.6 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](CCN)NC4=O)c2nc1NC(C)(C)C CHEMBL4541192 IC50 0.6 nM
CC(=O)NC1(C)CCCN(c2c(NC(=O)c3nc(-c4ncccc4F)sc3N)cnn2C)CC1 CHEMBL3648779 Ki 0.613 nM
Fc1ccccc1-c1n[nH]c2cnc(-c3cnccc3OCC3CCNCC3)cc12 CHEMBL3955029 Ki 0.614 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cnn(C)c4)cc23)nc1N1CC(N2CCNC(=O)C2)C1 CHEMBL3976240 Ki 0.618 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1NC(C)(C)C CHEMBL3974543 IC50 0.618 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)cn1 CHEMBL3892536 Ki 0.623 nM
Cc1nc2cccc(-c3[nH]c4c(c3Br)C(=O)NCC4)c2nc1NC(C)(C)C CHEMBL3964367 IC50 0.625 nM
CC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687436 IC50 0.63 nM
CC(C)(CN)COc1cccc2ccc(-c3nnc4ccc(C5CC5)cn34)nc12 CHEMBL3660061 IC50 0.64 nM
COc1ccc2c(c1CN1CCNCC1)O/C(=C\c1c[nH]c3nc(C)ccc13)C2=O CHEMBL4060711 IC50 0.64 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC(O)C(O)C3)n2)n1 CHEMBL3965243 Ki 0.644 nM
NC1CCC(Oc2cccc3ccc(-c4nnc5ccccn45)nc23)CC1 CHEMBL3660022 IC50 0.65 nM
CC(C)(CN)COc1cccc2ccc(-c3nnc4ccc(Br)cn34)nc12 CHEMBL3660060 IC50 0.65 nM
C[C@H](c1cn(C)cn1)n1c(NC2(C)CC2)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccc2c1=O CHEMBL4463004 IC50 0.65 nM
N[C@H]1CCC[C@@H](Oc2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 CHEMBL3920195 Ki 0.664 nM
CCn1ncc(NC(=O)c2nc(-c3ccccc3F)sc2N)c1N1CCC(N)C(OC)CC1 CHEMBL3648785 Ki 0.668 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCCS(=O)(=O)CC1 CHEMBL3648758 Ki 0.671 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC2CCC(C1)O2 CHEMBL3648749 Ki 0.678 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(C(F)(F)F)CC1 CHEMBL3961328 IC50 0.694 nM
O=c1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)[nH]1 CHEMBL3900423 Ki 0.698 nM
O=c1[nH]c(CN2CC[C@H](O)C2)nc2c1sc1ccc(-c3ccc(O)cc3)cc12 CHEMBL583187 Ki 0.7 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3cc(C(=O)NC(C)C)ccc3F)ccc2N)C[C@@H]1C CHEMBL3687535 IC50 0.7 nM
CC(C)(CO)COc1cccc2ccc(-c3nnc4cc(CN)ccn34)nc12 CHEMBL3660024 IC50 0.7 nM
FC1CCNCCC1Oc1cccc2ccc(-c3nnc4ccccn34)nc12 CHEMBL3660048 IC50 0.7 nM
FC1CCNCCC1Oc1cccc2ccc(-c3nnc4ccc(C5CC5)cn34)nc12 CHEMBL3660089 IC50 0.7 nM
COC1(COc2cc(F)cc3ccc(-c4nnc5ccccn45)nc23)CCCNCC1 CHEMBL3664617 IC50 0.7 nM
CCC1CNC(=O)c2cc(-c3cccc4ccc(Nc5ccccc5)nc34)[nH]c21 CHEMBL3902525 IC50 0.7 nM
CC[C@H]1CNC(=O)c2cc(-c3cccc4ccc(Nc5ccccc5)nc34)[nH]c21 CHEMBL3973604 IC50 0.7 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1CCNC1 CHEMBL3910145 IC50 0.7 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(C)CCCCC1 CHEMBL3918209 IC50 0.7 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1C[C@@H](NCCS(C)(=O)=O)C1 CHEMBL3918797 IC50 0.7 nM
NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CC3)n(C3CCCNC3)c2n1 CHEMBL4100435 IC50 0.7 nM
Cc1cncc(-c2cc3c(-c4cccc(N5CCCNCC5)n4)nsc3cn2)n1 CHEMBL4081716 Ki 0.7 nM
NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CC3)n([C@H]3CCCNC3)c2n1 CHEMBL4564586 IC50 0.7 nM
CC(O)C#Cc1c(Cl)c2c(Cl)cc(C(N)=O)nc2n1[C@H]1CCCNC1 CHEMBL4593810 Ki 0.7 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(NC(C)(C)CO)nc34)[nH]c21 CHEMBL4587256 IC50 0.7 nM
Cc1cn([C@@H](C)[C@H]2CCNC[C@H]2F)c2nc(C(N)=O)cc(Cl)c12 CHEMBL4759685 IC50 0.7 nM
Cc1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](N)C3)n2)sn1 CHEMBL3973544 Ki 0.71 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC2CCC(C2)C1 CHEMBL3648757 Ki 0.711 nM
CC1CCCCN1c1cncc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3980131 IC50 0.714 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(C3(F)CCCNCC3)n2)cn1 CHEMBL3975787 Ki 0.715 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC4(CCNCC4)C3)n2)n1 CHEMBL3956717 Ki 0.716 nM
c1cncc(-c2cc3c(-c4cnn(CC5CCNCC5)c4)n[nH]c3cn2)c1 CHEMBL3950139 Ki 0.717 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(-c5cccnc5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3912577 IC50 0.718 nM
CC(=O)N[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687441 IC50 0.72 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)C3(CC3)NC4=O)c2nc1NC(C)C CHEMBL3974046 IC50 0.724 nM
Clc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3946306 Ki 0.725 nM
CN(C)C(=O)c1ccc(F)c(-c2nc(C(=O)Nc3cnn(C)c3[C@@H]3CC[C@@H](N)[C@H](F)CO3)cs2)c1F CHEMBL4111691 Ki 0.727 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N(C)C)n2)n1 CHEMBL3984232 Ki 0.727 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ncc2N)C[C@@H]1C CHEMBL3687480 IC50 0.75 nM
CC(C)C1(COc2cccc3ccc(-c4nnc5ccccn45)nc23)CCNCC1 CHEMBL3660066 IC50 0.75 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1S(C)(=O)=O CHEMBL3687444 IC50 0.76 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3)ccc2N)c1N1CCC(N)CC1 CHEMBL3652624 Ki 0.762 nM
CO[C@@]1(C)CNCCN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)C1 CHEMBL3950820 Ki 0.763 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CC[C@H](N)C3)n2)n1 CHEMBL3943759 Ki 0.773 nM
N[C@H]1CCCN(c2ccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)cn2)C1 CHEMBL3900770 Ki 0.774 nM
N[C@H]1C[C@@H](F)CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C1 CHEMBL3913112 IC50 0.78 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC2(CNC2)C1 CHEMBL3648763 Ki 0.783 nM
Cn1ncc(NC(=O)c2csc(-c3ccccc3C(F)F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4114075 Ki 0.783 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CC(N)C3)n2)cn1 CHEMBL3919378 Ki 0.784 nM
Cn1cc(-c2nc(C(=O)Nc3cnn(C)c3N3CCC[C@H](N)CC3)c(N)s2)cn1 CHEMBL3648800 Ki 0.785 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691953 IC50 0.79 nM
Fc1ccc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3957313 Ki 0.796 nM
O=c1[nH]c(CNc2cccc(O)c2)nc2c1sc1ccc(Br)cc12 CHEMBL584161 Ki 0.8 nM
O=c1[nH]c(CN2CC[C@H](O)C2)nc2c1sc1ccc(/C=C/C3CC3)cc12 CHEMBL573463 Ki 0.8 nM
CC(C)(CO)COc1cccc2ccc(-c3nnc4ccccn34)nc12 CHEMBL3660029 IC50 0.8 nM
CC(C)(CN)COc1cccc2ccc(-c3nnc4ccc(-c5ccccc5)cn34)nc12 CHEMBL3660062 IC50 0.8 nM
FC1(COc2cccc3ccc(-c4nnc5ccccn45)nc23)CCNCC1 CHEMBL3664634 IC50 0.8 nM
CSc1ncc2ccc3c(C(N)=O)cn([C@H]4CC[C@@H](N)CC4)c3c2n1 CHEMBL3703184 IC50 0.8 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Nc5cncnc5)nc34)cc21 CHEMBL3967572 IC50 0.8 nM
Cc1cc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1Nc1ccccc1 CHEMBL3928492 IC50 0.8 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(C)CCC1 CHEMBL3904282 IC50 0.8 nM
Cc1nc2cccc(-c3cc4c([nH]3)C(C)CNC4=O)c2nc1F CHEMBL3947213 IC50 0.8 nM
CC[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3946176 IC50 0.8 nM
Cc1cncc(-c2cnc3cnn(-c4cccc(N5CCCNCC5)n4)c3c2)n1 CHEMBL4089586 Ki 0.8 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)C CHEMBL3959725 IC50 0.8 nM
CC[C@@H]1CN(c2cccc(-n3ncc4cnc(-c5cnn(CC)c5)cc43)n2)CCN1 CHEMBL4110363 Ki 0.802 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)cn1 CHEMBL3961525 Ki 0.817 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](N)C3=O)n2)n1 CHEMBL3952360 Ki 0.817 nM
N[C@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4cccnc4F)nn23)C1 CHEMBL3905239 IC50 0.83 nM
COC1CCN(c2c(NC(=O)c3nc(-c4ccccn4)sc3N)cnn2C)CCC1N CHEMBL3648736 Ki 0.833 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCCC4=O)c2nc1NC(C)(C)C CHEMBL3901863 IC50 0.839 nM
COc1ccc2c(c1CN1CCNCC1)O/C(=C\c1c[nH]c3ncccc13)C2=O CHEMBL2147767 IC50 0.84 nM
CC(=O)O[C@@H]1CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC[C@@H]1N CHEMBL3648849 Ki 0.846 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@@H](O)C3)n2)n1 CHEMBL4107092 Ki 0.854 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](N)C3)n2)cn1 CHEMBL3963946 Ki 0.867 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1OCC(=O)O CHEMBL3691974 IC50 0.87 nM
C[C@H]1CN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CCN1 CHEMBL3648672 Ki 0.876 nM
OC1CN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)C1 CHEMBL3906850 Ki 0.876 nM
Cc1ccncc1-c1nc(C(=O)Nc2cnn(C)c2N2CC[C@@H](N)[C@H](F)CC2)c(N)s1 CHEMBL3648809 Ki 0.884 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1C[C@H]2C[C@H](N)[C@@H](C1)O2 CHEMBL3648854 Ki 0.888 nM
N[C@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4ccccc4Cl)nn23)C1 CHEMBL3924352 IC50 0.89 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)c1N1CCC[C@@H](N)CC1 CHEMBL3652643 Ki 0.897 nM
O=c1[nH]c(CNc2cccc(O)c2)nc2c1sc1ccc(Cl)cc12 CHEMBL573476 Ki 0.9 nM
Fc1ccccc1-c1ccc2[nH]nc(-c3cncc(O[C@H]4CNCCC45CC5)n3)c2c1 CHEMBL3393708 IC50 0.9 nM
Cc1ccn2c(-c3ccc4cccc(OCC(C)(C)CN)c4n3)nnc2c1 CHEMBL3664622 IC50 0.9 nM
N[C@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4ncccc4Cl)nn23)C1 CHEMBL3920733 IC50 0.9 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Nc5c(F)cccc5F)nc34)cc21 CHEMBL3916900 IC50 0.9 nM
O=C1NCCc2[nH]c(-c3c(F)ccc4ccc(Nc5ccccc5)nc34)cc21 CHEMBL3964527 IC50 0.9 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CCCS(C)(=O)=O)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3932047 IC50 0.9 nM
NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CNCCO3)n([C@H]3CCCNC3)c2n1 CHEMBL4583118 Ki 0.9 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(N5CCCC5(C)C)nc34)[nH]c21 CHEMBL4572195 IC50 0.9 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)CO CHEMBL3927716 IC50 0.9 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(C3(O)CCCNC3)n2)n1 CHEMBL3974800 Ki 0.918 nM
NCCNc1cc(-c2n[nH]c3cnc(-c4cccnc4)cc23)ccn1 CHEMBL3965036 Ki 0.941 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(C3CNCCC3O)n2)n1 CHEMBL3895094 Ki 0.941 nM
CC1(COc2cccc3ccc(-c4nnc5ccccn45)nc23)CCNCC1 CHEMBL3660063 IC50 0.95 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@@H](N)C3)n2)cn1 CHEMBL4115315 Ki 0.951 nM
Cn1ncc(NC(=O)c2csc(-c3cc(=O)n(C)cc3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4110938 Ki 0.954 nM
C[C@@H]1CN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CCN1 CHEMBL3648657 Ki 0.958 nM
COC1(COc2cccc3ccc(-c4nnc5ccccn45)nc23)CCNCC1 CHEMBL3660069 IC50 0.96 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC[C@H](N(CC2COC2)CC2COC2)CC1 CHEMBL3648751 Ki 0.962 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3OC(F)(F)F)sc2N)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4111168 Ki 0.965 nM
Cn1ccc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)cc1=O CHEMBL3907357 Ki 0.97 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CC[C@@H](N)C3)n2)n1 CHEMBL4111423 Ki 0.977 nM
NCC1CCN(c2cncc(-c3n[nH]c4cnc(-c5cccnc5)cc34)c2)CC1 CHEMBL3955565 Ki 0.985 nM
Cn1ncc(NC(=O)c2csc(-c3cccnc3)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4108256 Ki 0.991 nM
Cn1ncc(NC(=O)c2nc(C3CCCC3)sc2N)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3912044 Ki 0.992 nM
CN(C)Cc1nc2c(sc3ccc(/C=C/C4CC4)cc32)c(=O)[nH]1 CHEMBL576387 Ki 1.0 nM
CN(C)Cc1nc2c(sc3ccc(-c4cccc(O)c4)cc32)c(=O)[nH]1 CHEMBL583913 Ki 1.0 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccc(O)c(F)c4)cc32)c(=O)[nH]1 CHEMBL572514 Ki 1.0 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccc(OCC(O)CO)cc4)cc32)c(=O)[nH]1 CHEMBL575463 Ki 1.0 nM
N[C@H]1CC[C@@H](Nc2cc(Br)cc3cc(C(=O)O)oc23)CC1 CHEMBL1782530 IC50 1.0 nM
Clc1ccccc1Nc1nc2c(-c3nnc[nH]3)cccc2c2cnccc12 CHEMBL1915438 IC50 1.0 nM
COc1cc(NCC2CCNCC2)nc2c1nnn2-c1cccc(OC(F)(F)F)c1 CHEMBL1952142 IC50 1.0 nM
Nc1nccc(-c2ccc(N)c(C(=O)Nc3cnccc3N3CCC[C@H](N)C3)n2)n1 CHEMBL3103863 Ki 1.0 nM
CN(C)C1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(-c4cccc(Cl)c4)cn32)C2CCCCC2)CC1 CHEMBL3297766 IC50 1.0 nM
O=C(Nc1cnccc1OC1CCNCC1)c1csc(-c2c(F)cccc2F)n1 CHEMBL3354513 IC50 1.0 nM
O=C(Nc1cnccc1OC1CCCCC1)c1csc(-c2c(F)cccc2F)n1 CHEMBL3354514 IC50 1.0 nM
O=C(Nc1cnccc1OCC1CCOCC1)c1csc(-c2c(F)cccc2F)n1 CHEMBL3354516 IC50 1.0 nM
O=C(Nc1cnccc1O[C@H]1CC[C@H](O)CC1)c1csc(-c2c(F)cccc2F)n1 CHEMBL3354517 IC50 1.0 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1O[C@H]1CCNC1 CHEMBL3354518 IC50 1.0 nM
Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(OC4CNCCC45CC5)n3)c2c1 CHEMBL3393704 IC50 1.0 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(NC5CCCC5)n4)c3c2)s1 CHEMBL3394164 IC50 1.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](O)[C@@H](C)C3)ccc2F)c1 CHEMBL3651969 IC50 1.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)C[C@@H](N)[C@H]1O CHEMBL3651989 IC50 1.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3ccc(O)cc3F)n2)C1 CHEMBL3651905 IC50 1.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2cccc(-c3c(F)cccc3F)n2)C[C@@H](O)[C@@H]1O CHEMBL3652009 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3ccc(F)cc3F)n2)C1 CHEMBL3651973 IC50 1.0 nM
CC1(C)C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(O)cc3F)n2)C1 CHEMBL3652016 IC50 1.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@@H]3CCC[C@H](N)C3)n2)c1F CHEMBL3651924 IC50 1.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2F)C[C@@H](N)[C@@H]1O CHEMBL3651920 IC50 1.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2cccc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3651922 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2cccc(-c3cc(O)ccc3F)n2)C1 CHEMBL3651931 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3ccccc3F)n2)C1 CHEMBL3651953 IC50 1.0 nM
N[C@@H]1C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)CC[C@@H]1O CHEMBL3651984 IC50 1.0 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)CC(C)(C)C3)ccc2F)c(F)c1 CHEMBL3652017 IC50 1.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@@H]3C[C@H](N)C[C@H](N)C3)n2)c1F CHEMBL3651925 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3cc(F)ccc3F)n2)C1 CHEMBL3651957 IC50 1.0 nM
CCc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](O)[C@@H](C)C3)n2)c1F CHEMBL3651913 IC50 1.0 nM
C[C@@H]1C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)C[C@H](N)[C@H]1O CHEMBL3651990 IC50 1.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3ccccc3F)n2)C[C@@H](O)[C@@H]1O CHEMBL3652008 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3cc(O)ccc3F)ccc2F)C1 CHEMBL3651939 IC50 1.0 nM
Nc1cc(F)c(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@@H]1CC[C@H](O)[C@H](N)C1 CHEMBL3651961 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)ccc(F)c3F)n2)C1 CHEMBL3652023 IC50 1.0 nM
Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@H]1C[C@@H](N)C[C@@H](C(F)(F)F)C1 CHEMBL3652006 IC50 1.0 nM
CCCOc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3CC[C@H](O)[C@H](N)C3)c(N)cc2F)c1 CHEMBL3651963 IC50 1.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)CC(C)(C)C3)ccc2F)c1F CHEMBL3651907 IC50 1.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](O)[C@@H]1O CHEMBL3652015 IC50 1.0 nM
CC1CC(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)=CC(O)C1 CHEMBL3652029 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3cc(O)ccc3F)n2)C1 CHEMBL3651942 IC50 1.0 nM
Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@@H]1CC[C@H](O)[C@H](N)C1 CHEMBL3651996 IC50 1.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(C3CCCCC3)n2)C[C@@H](N)[C@@H]1O CHEMBL3651912 IC50 1.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(O)cc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3651900 IC50 1.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)CC(C)(C)C3)n2)c1F CHEMBL3651908 IC50 1.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](O)[C@@H](C)C3)n2)c1 CHEMBL3651970 IC50 1.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@H]1O CHEMBL3652025 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3ccc(O)cc3F)n2)C1 CHEMBL3651934 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cc(O)cc3F)ccc2F)C1 CHEMBL3651938 IC50 1.0 nM
COc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@H](O)[C@@H](C)C3)ccc2F)c1F CHEMBL3651943 IC50 1.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@H](O)[C@@H](C)C3)ccc2F)c1F CHEMBL3651918 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C1 CHEMBL3651947 IC50 1.0 nM
C[C@@H]1C[C@H](O)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C1 CHEMBL3651898 IC50 1.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3651946 IC50 1.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(O)cc3F)n2)C1 CHEMBL3651928 IC50 1.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@H](O)[C@@H](C)C3)n2)c1F CHEMBL3651909 IC50 1.0 nM
CC1(C)C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3ccc(O)cc3F)n2)C1 CHEMBL3651906 IC50 1.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)C[C@@H](C(F)(F)F)C3)n2)c1 CHEMBL3652002 IC50 1.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(O)cc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3651899 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)ccc(O)c3F)n2)C1 CHEMBL3652019 IC50 1.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](O)[C@@H](C)C3)ccc2F)c1F CHEMBL3651936 IC50 1.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@H](O)[C@@H](C)C3)ccc2F)c1F CHEMBL3651940 IC50 1.0 nM
COc1cc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)C[C@@H](C(F)(F)F)C3)n2)c(F)c1 CHEMBL3652003 IC50 1.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2cccc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1O CHEMBL3651972 IC50 1.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3ccccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3651921 IC50 1.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1O CHEMBL3651981 IC50 1.0 nM
Nc1cc(F)c(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@@H]1CCC[C@H](N)C1 CHEMBL3651994 IC50 1.0 nM
Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1C1=C[C@@H](N)[C@@H](O)CC1 CHEMBL3651988 IC50 1.0 nM
CC1CC(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)=CC(O)C1 CHEMBL3651999 IC50 1.0 nM
Nc1cc(F)c(-c2ccccc2F)nc1C(=O)Nc1cnccc1[C@@H]1CC[C@H](O)[C@H](N)C1 CHEMBL3651962 IC50 1.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C1 CHEMBL3651993 IC50 1.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](O)[C@@H]1O CHEMBL3652010 IC50 1.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](O)[C@@H]1O CHEMBL3652011 IC50 1.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3ccncc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3652013 IC50 1.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2cccc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3651948 IC50 1.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)C[C@H](N)C3)n2)c1 CHEMBL3651954 IC50 1.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)ccc(O)c3F)n2)C1 CHEMBL3652018 IC50 1.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3ccccc3F)n2)C[C@@H](N)[C@H]1O CHEMBL3651971 IC50 1.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2cccc(-c3cc(O)ccc3F)n2)C1 CHEMBL3651903 IC50 1.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1F CHEMBL3652031 IC50 1.0 nM
CC1(C)C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C1 CHEMBL3651945 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3cccc(F)c3F)n2)C1 CHEMBL3651956 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2cccc(-c3ccccc3F)n2)C1 CHEMBL3651958 IC50 1.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3cc(O)ccc3F)n2)C1 CHEMBL3651929 IC50 1.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)C[C@H](N)C3)ccc2F)c1 CHEMBL3651955 IC50 1.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)C[C@H](N)C3)ccc2F)c1F CHEMBL3651923 IC50 1.0 nM
CCCOc1ccc(F)c(-c2ccc(N)c(C(=O)Nc3cnccc3[C@@H]3CC[C@H](O)[C@H](N)C3)n2)c1 CHEMBL3651964 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2cccc(-c3c(F)cc(O)cc3F)n2)C1 CHEMBL3651932 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(O)cc3F)n2)C1 CHEMBL3652022 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2cccc(-c3c(F)cccc3F)n2)C1 CHEMBL3651959 IC50 1.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2cccc(-c3c(F)cc(O)cc3F)n2)C1 CHEMBL3651904 IC50 1.0 nM
Nc1cc(F)c(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@H]1C[C@@H](N)C[C@@H](C(F)(F)F)C1 CHEMBL3652004 IC50 1.0 nM
COc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)C[C@H](N)C3)ccc2F)c1 CHEMBL3651941 IC50 1.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3CCC[C@H](N)C3)ccc2F)c1F CHEMBL3651916 IC50 1.0 nM
Cc1nc2cccc3c2nc1N[C@@H](C)CCC[C@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3809127 IC50 1.0 nM
Cc1nc2cccc3c2nc1NC/C=C/C[C@@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3809044 IC50 1.0 nM
Cc1nc2cccc3c2nc1NC/C=C/C[C@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3809463 IC50 1.0 nM
N[C@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4nccs4)nn23)C1 CHEMBL3910008 IC50 1.0 nM
c1cc(OCC2CCCNC2)c2nc(-c3nnc4ccccn34)ccc2c1 CHEMBL3660021 IC50 1.0 nM
Cc1ccn2c(-c3ccc4cccc(OC5CCNCCC5F)c4n3)nnc2c1 CHEMBL3660086 IC50 1.0 nM
COC1(COc2cccc3ccc(-c4nnc5ccccn45)nc23)CCCNCC1 CHEMBL3664620 IC50 1.0 nM
COC1(COc2cccc3ccc(-c4nnc5cc(C)ccn45)nc23)CCNCC1 CHEMBL3664624 IC50 1.0 nM
CC(C)(CCN)COc1cccc2ccc(-c3nnc4ccccn34)nc12 CHEMBL3664629 IC50 1.0 nM
N[C@H]1CCCN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676258 IC50 1.0 nM
N[C@@H]1CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)CC[C@@H]1O CHEMBL3676262 IC50 1.0 nM
NC1CC(C(F)(F)F)CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676271 IC50 1.0 nM
NC1CC(CF)CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676272 IC50 1.0 nM
CC1CCN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)CC1N CHEMBL3676275 IC50 1.0 nM
CC[C@@H]1C[C@H](N)CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676281 IC50 1.0 nM
N[C@H]1C[C@@H](C(F)(F)F)CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676283 IC50 1.0 nM
C[C@@H]1C[C@H](N)CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676284 IC50 1.0 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1N1CCC(F)CC1 CHEMBL3676286 IC50 1.0 nM
C[C@@H]1C[C@H](O)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C1 CHEMBL3676288 IC50 1.0 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@@H]1CCC[C@H](N)C1 CHEMBL3676289 IC50 1.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3676292 IC50 1.0 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@@H]1CC[C@H](O)[C@H](N)C1 CHEMBL3676294 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676300 IC50 1.0 nM
CC1(C)C[C@H](N)C[C@H](c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676301 IC50 1.0 nM
COc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)C[C@H](N)C3)cs2)c1F CHEMBL3676305 IC50 1.0 nM
CC(C)Oc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)C[C@H](N)C3)cs2)c1F CHEMBL3676306 IC50 1.0 nM
CCOc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)C[C@H](N)C3)cs2)c1F CHEMBL3676307 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2csc(-c3c(F)ccc(Cl)c3F)n2)C1 CHEMBL3676309 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2csc(-c3c(F)cc(O)cc3F)n2)C1 CHEMBL3676310 IC50 1.0 nM
CN1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(-c4cccc(Cl)c4)cn32)C2CCCCC2)CC1 CHEMBL3297762 IC50 1.0 nM
CN1CCN(Cc2ccc(-c3c(-c4cccc(OC(F)(F)F)c4)cc4n3C(CCOC(=O)C(F)(F)F)CNC4=O)cc2)CC1 CHEMBL3903884 IC50 1.0 nM
NCC[C@H]1CNC(=O)c2cc(-c3cccc(OC(F)(F)F)c3)c(-c3ccc(O)cc3)n21 CHEMBL3971118 IC50 1.0 nM
CS(=O)(=O)c1ccc(-c2c(-c3cccc(OC(F)(F)F)c3)cc3n2[C@@H](CCN)CNC3=O)cc1 CHEMBL3949477 IC50 1.0 nM
CN1CCN(Cc2ccc(-c3c(-c4cccc(OC(F)(F)F)c4)cc4n3[C@@H](CCN)CNC4=O)cc2)CC1 CHEMBL3912707 IC50 1.0 nM
CN(C)Cc1ccc(-c2c(-c3cccc(OC(F)(F)F)c3)cc3n2[C@@H](CCN)CNC3=O)cc1 CHEMBL3935180 IC50 1.0 nM
CN1CCN(Cc2ccc(-c3c(-c4cccc(OC(F)(F)F)c4)cc4n3[C@@H](CCCN)CNC4=O)cc2)CC1 CHEMBL3967392 IC50 1.0 nM
NCC[C@H]1CNC(=O)c2cc(-c3cccc(OC(F)(F)F)c3)c(-c3ccc(S(N)(=O)=O)cc3)n21 CHEMBL3973012 IC50 1.0 nM
NCC[C@H]1CNC(=O)c2cc(-c3cccc(OC(F)(F)F)c3)c(-c3ccc(C4(N)CC4)cc3)n21 CHEMBL3957977 IC50 1.0 nM
C[C@@H]1C[C@H](N)CN(c2ccncc2Nc2nnc3ccc(-c4c(F)cccc4F)nn23)C1 CHEMBL4108287 IC50 1.0 nM
N[C@H]1CCN(c2ccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)cn2)C1 CHEMBL3918765 Ki 1.0 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Nc5c(F)cccc5Cl)nc34)cc21 CHEMBL3939032 IC50 1.0 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(N[C@H]5CCCNC5)nc34)cc21 CHEMBL3920246 IC50 1.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(CO)CC1 CHEMBL3891210 IC50 1.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)CCO CHEMBL3918196 IC50 1.0 nM
CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1Cl CHEMBL3918158 IC50 1.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1C[C@@H](NCCF)C1 CHEMBL3902504 IC50 1.0 nM
COC[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3961876 IC50 1.0 nM
C[C@H]1NC(=O)c2cc(-c3cccc4cnc(NC5(C)CC5)nc34)[nH]c21 CHEMBL3935407 IC50 1.0 nM
CC[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5CC5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3948310 IC50 1.0 nM
CC(C)(O)[C@H]1CC[C@H](Nc2ccc3ncc(-c4cccc(C(F)(F)F)c4)n3n2)CC1 CHEMBL3975308 IC50 1.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(C3CC3)n([C@H]3CCCNC3)c2n1 CHEMBL4104355 IC50 1.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(C3CC3)n(C3CCCNC3)c2n1 CHEMBL4082422 IC50 1.0 nM
Cn1cc(-c2c(Cl)c3c(Cl)cc(C(N)=O)nc3n2C2CCCNC2)cn1 CHEMBL4062258 IC50 1.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCCNCC3)c2n1 CHEMBL4067797 IC50 1.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCCC(N)C3)c2n1 CHEMBL4095220 IC50 1.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCC(N)CC3)c2n1 CHEMBL4070441 IC50 1.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCCNC3)c2n1 CHEMBL4084988 IC50 1.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(I)n(CC3CCNC3)c2n1 CHEMBL4093592 IC50 1.0 nM
Cc1cn([C@@H](C)[C@]2(F)CCNC2)c2nc(C(N)=O)cc(Cl)c12 CHEMBL4778578 IC50 1.0 nM
Cc1cn([C@H](C)[C@H]2CCNC[C@@H]2F)c2nc(C(N)=O)cc(Cl)c12 CHEMBL4750046 IC50 1.0 nM
Cc1cn([C@H](C)[C@@H]2CCNC[C@H]2F)c2nc(C(N)=O)cc(Cl)c12 CHEMBL4745141 IC50 1.0 nM
CC[C@]1(O)[C@H](O)C[C@H](c2ccncc2NC(=O)c2nc(-c3ncccc3F)ccc2N)C[C@@H]1C CHEMBL4742957 Ki 1.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3ncccc3F)ccc2N)C[C@@H](O)[C@]1(C)O CHEMBL4781112 Ki 1.0 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(NC5CCCC5)n4)c3c2)o1 CHEMBL3917311 IC50 1.009 nM
COCC1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3894748 IC50 1.01 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCNCCC1=O CHEMBL3648735 Ki 1.02 nM
N[C@@H]1CCN(c2ccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)cn2)C1 CHEMBL4114227 Ki 1.02 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cnn(C)c4)cc23)nc1N1CC(N2CCS(=O)(=O)CC2)C1 CHEMBL3893478 Ki 1.02 nM
Cc1cc(-c2nc(C(=O)Nc3cnn(C)c3N3CC[C@@H](N)[C@H](F)CC3)c(N)s2)ccn1 CHEMBL3648812 Ki 1.04 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCC(N)CC3)n2)cn1 CHEMBL3958302 Ki 1.04 nM
N#Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3975199 Ki 1.04 nM
CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1/C=N/O CHEMBL3898395 IC50 1.05 nM
COc1ncccc1-c1nc(C(=O)Nc2cnn(C)c2N2CCC[C@H](N)CC2)c(N)s1 CHEMBL3648799 Ki 1.08 nM
Cn1ncc(NC(=O)c2nc(-c3cc(C#N)ccc3F)sc2N)c1N1CC[C@@H](N)[C@H](F)CC1 CHEMBL3648818 Ki 1.08 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CC(O)(CN)C3)n2)cn1 CHEMBL3959634 Ki 1.08 nM
N#Cc1ccc(Cc2cc(O)n3ncc(C(=O)Nc4ccc(F)cc4)c3n2)cc1 CHEMBL2387467 Ki 1.1 nM
N[C@H]1C=C(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)CCC1 CHEMBL4115439 IC50 1.1 nM
CCN(c1ccccc1)c1ccc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3903003 IC50 1.1 nM
Nc1cccc(Nc2ccc3cccc(-c4cc5c([nH]4)CCNC5=O)c3n2)c1 CHEMBL3986342 IC50 1.1 nM
O=C1NCCn2cc(-c3cccc4ccc(Nc5cccnc5)nc34)cc21 CHEMBL3906821 IC50 1.1 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(NC5CC5)nc34)cc21 CHEMBL3923078 IC50 1.1 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CC4(CCCCN4)C3)n2)cn1 CHEMBL3975766 Ki 1.1 nM
CCc1ccc2c(/C=C3\Oc4c(ccc(OC)c4CN4CCNCC4)C3=O)c[nH]c2n1 CHEMBL4074201 IC50 1.1 nM
COc1ncccc1-c1nc(C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@H](F)CO2)cs1 CHEMBL4114489 Ki 1.11 nM
N[C@@H]1CCCN(c2cccc(-c3n[nH]c4cnc(-n5ccnc5)cc34)n2)C1 CHEMBL4109201 Ki 1.13 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1OCC1CCNCC1 CHEMBL3652628 Ki 1.14 nM
C[C@@H]1CNCCN1c1c(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)cnn1C CHEMBL3648667 Ki 1.14 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(NCC5CC5)n4)c3c2)o1 CHEMBL3890140 IC50 1.161 nM
Cc1ncccc1-c1nc(C(=O)Nc2cnn(C)c2N2CC[C@@H](N)[C@H](F)CC2)c(N)s1 CHEMBL3648811 Ki 1.17 nM
Cn1cc(-c2cc3c(-c4cccc(N5C[C@H](N)C[C@@H](F)C5)n4)n[nH]c3cn2)cn1 CHEMBL4108390 Ki 1.17 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(C3=CCNCC3)n2)n1 CHEMBL3973175 Ki 1.17 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CC4(CCNC4)C3)n2)n1 CHEMBL3958435 Ki 1.17 nM
Cc1nc2cccc(-c3cc4c([nH]3)CNC4=O)c2nc1NC(C)(C)C CHEMBL3940411 IC50 1.18 nM
CC(C)Nc1nnc(-c2ccc3[nH]cc(-c4ncc(C(N)=O)c(C5CC5)n4)c3c2)o1 CHEMBL3981514 IC50 1.19 nM
CNc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)C CHEMBL3893675 IC50 1.19 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CC(O)C(O)C3)n2)n1 CHEMBL3934298 Ki 1.19 nM
CS(=O)(=O)c1ccc(-c2ccc3cnc(Nc4cnccc4N4CCC[C@H](N)C4)n3n2)c(F)c1 CHEMBL3957474 IC50 1.2 nM
N[C@@H]1C=C(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)CCC1 CHEMBL3940201 IC50 1.2 nM
CC(C)Nc1nnc(-c2ccc3[nH]cc(-c4cc(=O)[nH]c(C5CC5)n4)c3c2)o1 CHEMBL3913006 IC50 1.2 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Nc5ccccc5F)nc34)cc21 CHEMBL3968570 IC50 1.2 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)C(C)C CHEMBL3967917 IC50 1.2 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(C)CCOCC1 CHEMBL3892409 IC50 1.2 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C[C@H]5CN(C)CCO5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4443684 IC50 1.2 nM
CC1(C#Cc2c(Cl)c3c(Cl)cc(C(N)=O)nc3n2[C@H]2CCCNC2)COC1 CHEMBL4470576 Ki 1.2 nM
CN1CC(C#Cc2c(Cl)c3c(Cl)cc(C(N)=O)nc3n2[C@H]2CCCNC2)CC1=O CHEMBL4563802 Ki 1.2 nM
FC(F)n1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3981104 Ki 1.21 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC4(CCNC4)CC3)n2)n1 CHEMBL3982105 Ki 1.21 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)sc2N)c1N1CCC[C@H](N)C1 CHEMBL3652623 Ki 1.22 nM
c1cc(-c2n[nH]c3cnc(-c4cncs4)cc23)nc(N2CCCCC2)c1 CHEMBL3975794 Ki 1.22 nM
Cc1nc2cccc(-c3cc4c(=O)[nH]cnc4[nH]3)c2nc1NC(C)(C)C CHEMBL3934918 IC50 1.22 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1NCC(F)(F)F CHEMBL3903517 IC50 1.23 nM
NCC1CN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)C1 CHEMBL3926614 Ki 1.23 nM
Cn1ncc(NC(=O)c2nc(-c3ccccn3)sc2N)c1N1CC[C@@H](N)[C@H](F)CC1 CHEMBL3648716 Ki 1.25 nM
Cc1nc2cccc(-c3cc4c([nH]3)CNC4=O)c2nc1NCC(F)(F)F CHEMBL3961776 IC50 1.25 nM
CC[C@]1(CO)CO[C@@H](c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)OC1 CHEMBL3953724 Ki 1.26 nM
Fc1ccccc1-c1n[nH]c2cnc(-c3cnccc3OC[C@H]3CCNC3)cc12 CHEMBL3894135 Ki 1.28 nM
CC(C)(CN)Cn1cc(-c2n[nH]c3cnc(-c4cccnc4)cc23)ccc1=O CHEMBL3926312 Ki 1.29 nM
Cc1nnc(-c2cccc(-c3cnn4ccc(NCCN)nc34)c2)o1 CHEMBL2442291 IC50 1.3 nM
CCC1(COc2cccc3ccc(-c4nnc5ccccn45)nc23)CCNCC1 CHEMBL3660064 IC50 1.3 nM
CN1CCC(F)C(Oc2cccc3ccc(-c4nnc5ccccn45)nc23)CC1 CHEMBL3664621 IC50 1.3 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@@H]1CC[C@@H]1N CHEMBL3910979 IC50 1.3 nM
CC(C)(C)Nc1cnc2cccc(-c3cc4n(c3)CCNC4=O)c2n1 CHEMBL3922362 IC50 1.3 nM
CC1(C)CCCCN1c1cnc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3935709 IC50 1.3 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H](C)C1CC1 CHEMBL3904800 IC50 1.3 nM
O=C1/C(=C/c2c[nH]c3nc(Cl)ccc23)Oc2c1ccc(O)c2CN1CCNCC1 CHEMBL4061176 IC50 1.3 nM
NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CCCO3)n([C@H]3CCCNC3)c2n1 CHEMBL4518492 Ki 1.3 nM
NC1CCN(c2cncc(-c3cc4c(-c5ccccc5F)n[nH]c4cn3)c2)CC1 CHEMBL3960318 Ki 1.31 nM
Cc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](C)[C@@H](OCCC#N)[C@@H](N)C3)ccc2F)c(F)c1 CHEMBL3687494 IC50 1.33 nM
c1cc2[nH]cc(-c3cncc(C4CC4)n3)c2cc1-c1nnc(NC2CNC2)o1 CHEMBL3905618 IC50 1.339 nM
Cc1nc2cccc(-c3cc4n(c3)CCNC4=O)c2nc1NC1(C)CC1 CHEMBL3978475 IC50 1.34 nM
COCCOCCn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccc2c1=O CHEMBL3918647 IC50 1.34 nM
NC1CCCN(c2cncc(-c3n[nH]c4cnc(-c5cccnc5)cc34)c2)CC1 CHEMBL3929444 Ki 1.35 nM
CCN(c1nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccc2c(=O)[nH]1)C(C)C CHEMBL3944889 IC50 1.39 nM
CC(C)Nc1nnc(-c2ccc3[nH]cc(-c4cncc(C5CC5)n4)c3c2)o1 CHEMBL3932201 IC50 1.393 nM
CC(C)Nc1nnc(-c2ccc3[nH]cc(-c4nccc(C5CC5)n4)c3c2)o1 CHEMBL3919337 IC50 1.396 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 Kd 1.4 nM
CS(=O)(=O)c1ccc(-c2ccc3[nH]nc(-c4cncc(O[C@H]5CNCCC56CC6)n4)c3c2)c(F)c1 CHEMBL3393719 IC50 1.4 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1S(C)(=O)=O CHEMBL3687529 IC50 1.4 nM
Fc1ccc2nnc(-c3ccc4cccc(OCC5(F)CCNCC5)c4n3)n2c1 CHEMBL3660093 IC50 1.4 nM
COC1(COc2cc(F)cc3ccc(-c4nnc5ccccn45)nc23)CCCN(CCO)CC1 CHEMBL3664618 IC50 1.4 nM
Cn1ncc(NC(=O)c2nc(-c3ccccn3)sc2N)c1N1CC[C@@H](F)[C@@H](N)CC1 CHEMBL3648782 Ki 1.4 nM
CN1CCN(c2cc(-c3nc(/C=C4\SC(=S)NC4=O)cs3)ccn2)CC1 CHEMBL4060012 IC50 1.4 nM
CCn1cc(-c2cc3c(-c4ccc(=O)n(CC5(C(N)=O)CC5)c4)n[nH]c3cn2)cn1 CHEMBL3915842 Ki 1.41 nM
Cc1nc2cccc(-c3cc4c([nH]3)C(CO)NC4=O)c2nc1NC1(C)CC1 CHEMBL3948398 IC50 1.42 nM
Cn1ncc(NC(=O)c2nc(-c3cccc(C#N)n3)sc2N)c1N1CC[C@@H](N)[C@H](F)CC1 CHEMBL3648813 Ki 1.44 nM
C[C@@H]1C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@H](N)[C@@H]1C#N CHEMBL3687477 IC50 1.48 nM
COc1ccc(C(F)F)c(F)c1-c1nc(C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@H](F)CO2)cs1 CHEMBL4109105 Ki 1.48 nM
COc1cc(NCC2CCNCC2)nc2c1nnn2-c1cccc(N(C)C)c1 CHEMBL1952143 IC50 1.5 nM
NCCNc1ccn2ncc(-c3ccc4ccccc4c3)c2n1 CHEMBL2442296 IC50 1.5 nM
N[C@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4ccccn4)nn23)C1 CHEMBL3937423 IC50 1.5 nM
CC(C)(CN)COc1cccc2ccc(-c3nnc4ccccn34)nc12 CHEMBL3660023 IC50 1.5 nM
Cc1ccc2nnc(-c3ccc4cccc(OC5CCNCCC5F)c4n3)n2c1 CHEMBL3660090 IC50 1.5 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Nc5cccc(F)c5)nc34)cc21 CHEMBL3906206 IC50 1.5 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Nc5ccccc5Cl)nc34)cc21 CHEMBL3981805 IC50 1.5 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1Nc1ccccc1 CHEMBL3810085 IC50 1.5 nM
CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2c(=O)n1-c1cccnc1 CHEMBL3978132 IC50 1.5 nM
NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CCOCC3)n([C@H]3CCCNC3)c2n1 CHEMBL4528544 IC50 1.5 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(N(C)C(C)(C)C)nc34)[nH]c21 CHEMBL4589855 IC50 1.5 nM
CC(C)Nc1cncc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3912741 IC50 1.501 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCN(C4COC4)CC3)n2)n1 CHEMBL3900796 Ki 1.51 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(C3CCCNCC3)n2)cn1 CHEMBL3986159 Ki 1.55 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC(N)CC3)n2)cn1 CHEMBL3968140 Ki 1.56 nM
N[C@H]1CCN(c2ccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)nc2)C1=O CHEMBL3936599 Ki 1.57 nM
CC(C)(C)Nc1nnc(-c2ccc3[nH]cc(-c4nccc(C5CC5)n4)c3c2)o1 CHEMBL3969942 IC50 1.578 nM
Cn1cc(-c2cc3c(-c4ccc(Br)c(N5CC(N6CCS(=O)(=O)CC6)C5)n4)n[nH]c3cn2)cn1 CHEMBL3893806 Ki 1.59 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)[C@H]([C@@H](C)O)NC4=O)c2nc1NC1CC1 CHEMBL3918771 IC50 1.59 nM
CCN1CCCC1CNc1ccn2ncc(-c3ccc4ccccc4c3)c2n1 CHEMBL2442301 IC50 1.6 nM
c1ccc(-c2ccc3[nH]nc(-c4cncc(O[C@H]5CNCCC56CC6)n4)c3c2)cc1 CHEMBL3393709 IC50 1.6 nM
c1cc(NC2CCNCC2)c2nc(-c3nnc4ccccn34)ccc2c1 CHEMBL3660006 IC50 1.6 nM
c1cc(OCC2(CC3CC3)CCNCC2)c2nc(-c3nnc4ccccn34)ccc2c1 CHEMBL3660065 IC50 1.6 nM
FC1(COc2cccc3ccc(-c4nnc5ccccn45)nc23)CCCNC1 CHEMBL3664630 IC50 1.6 nM
C[C@@H]1C[C@H](N)CN(c2ccncc2Nc2nnc3ccc(-c4ncccc4F)nn23)C1 CHEMBL4113226 IC50 1.6 nM
NC[C@H]1CCN(c2cncc(-c3n[nH]c4cnc(-c5cccnc5)cc34)c2)C1 CHEMBL4112208 Ki 1.6 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Nc5ccccc5)nc34)cc21 CHEMBL3942833 IC50 1.6 nM
Cc1nc2cccc(-c3cc4c([nH]3)C3(CC3)CNC4=O)c2nc1NC1CC1 CHEMBL3889626 IC50 1.6 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CCC1 CHEMBL3960320 IC50 1.6 nM
CC1(C)COCCN1c1cnc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3963777 IC50 1.6 nM
Cc1nc2cccc(-c3cc4c(=O)[nH]cnc4[nH]3)c2nc1NC1CCC1 CHEMBL3986567 IC50 1.6 nM
Cc1nc2cccc(-c3cc4c([nH]3)C3(CC3)NC4=O)c2nc1NCC(F)(F)F CHEMBL3973280 IC50 1.6 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc3c(n2)CC(CN)CO3)n1 CHEMBL3900881 Ki 1.6 nM
COCC(C)(C)C#Cc1c(Cl)c2c(Cl)cc(C(N)=O)nc2n1[C@H]1CCCNC1 CHEMBL4457529 IC50 1.6 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@H](C)NC4=O)c2nc1NC(C)(C)C CHEMBL3918714 IC50 1.6 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=S)c2nc1NC(C)(C)C CHEMBL3934590 IC50 1.61 nM
C#Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)C CHEMBL3929651 IC50 1.63 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cncc(N3CCCNCC3)n2)cn1 CHEMBL3953538 Ki 1.63 nM
C[C@]1(O)CNCCN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)C1 CHEMBL3930725 Ki 1.64 nM
Cn1ncc(NC(=O)c2csc(-c3ccccc3C(F)(F)F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4112684 Ki 1.65 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cnc(Cl)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3947370 Ki 1.65 nM
Cc1nc2cccc(-c3cc4c([nH]3)C(COCc3ccccc3)NC4=O)c2nc1NC1CC1 CHEMBL3933159 IC50 1.66 nM
Cc1nc2cccc(-c3cc4c([nH]3)C3(CC3)NC4=O)c2nc1NCC(F)F CHEMBL3899535 IC50 1.67 nM
COC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3cc(C(=O)NC(C)C)ccc3F)ccc2N)C[C@@H]1C CHEMBL3691983 IC50 1.7 nM
NC(=O)c1cc(Cl)c2c(Cl)c(C#CCO)n([C@H]3CCCNC3)c2n1 CHEMBL4466080 IC50 1.7 nM
NCC1CCN(c2cncc(-c3cc4c(-c5ccccc5F)n[nH]c4cn3)c2)CC1 CHEMBL3966702 Ki 1.71 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@H](CO)NC4=O)c2nc1NC1(C)CC1 CHEMBL3935312 IC50 1.73 nM
CC(=O)N[C@@H]1CCC[C@H](Nc2nc3c(-c4cc5c([nH]4)[C@@H](C)NC5=O)cccc3nc2C)C1 CHEMBL3919258 IC50 1.73 nM
CC(C)Nc1cncc(-c2c[nH]c3ccc(-c4nnc(N)s4)cc23)n1 CHEMBL3394074 IC50 1.754 nM
C[C@H]1CCCCN1c1cccc(-c2c[nH]c3ccc(-c4nnc(N)s4)cc23)n1 CHEMBL3900171 IC50 1.766 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(NCC5CC5)n4)c3c2)s1 CHEMBL3925863 IC50 1.767 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccnc(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687461 IC50 1.77 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1NC(C)C CHEMBL3934338 IC50 1.78 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cccc(N5CCCC[C@@H]5N)n4)c3c2)s1 CHEMBL4108864 IC50 1.789 nM
Cc1nc2cccc(-c3cc4c([nH]3)C(COCc3ccccc3)NC4=O)c2nc1NC1(C)CC1 CHEMBL3934242 IC50 1.79 nM
N[C@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4ccc(Cl)cc4Cl)nn23)C1 CHEMBL3970651 IC50 1.8 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Nc5cccc(Cl)c5)nc34)cc21 CHEMBL3949372 IC50 1.8 nM
COc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)C CHEMBL3919294 IC50 1.8 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)C CHEMBL3970766 IC50 1.8 nM
O=C1/C(=C/c2c[nH]c3nc(F)ccc23)Oc2c1ccc(O)c2CN1CCNCC1 CHEMBL4092704 IC50 1.8 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C[C@@H]5CCCO5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4556760 IC50 1.8 nM
c1cc(-c2n[nH]c3cnc(-n4ccnc4)cc23)nc(N2CCNCC2)c1 CHEMBL3634773 Ki 1.82 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1NC(C)(C)CO CHEMBL3939819 IC50 1.84 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)ccc(S(C)(=O)=O)c3F)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4108976 Ki 1.85 nM
c1cc(N2CCCNCC2)nc(-n2ncc3cnc(-c4cnn(CC5CC5)c4)cc32)c1 CHEMBL3944819 Ki 1.86 nM
CO[C@H]1C[C@H](c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)OCC[C@@H]1N CHEMBL3957667 Ki 1.87 nM
COc1ccc2c(c1C(C)N1CCNCC1)O/C(=C\c1n[nH]c3ncccc13)C2=O CHEMBL3735890 IC50 1.9 nM
COc1ccc2nnc(-c3ccc4cc(F)cc(OCC5(F)CCNCC5)c4n3)n2c1 CHEMBL3664613 IC50 1.9 nM
N[C@H]1CCCN(c2ccncc2NC(=O)c2csc(-c3ccccc3F)n2)C1 CHEMBL3676303 IC50 1.9 nM
NC[C@H]1CCN(c2cncc(-c3cc4c(-c5ccccc5F)n[nH]c4cn3)c2)C1 CHEMBL4108596 Ki 1.9 nM
O=C1NCCc2[nH]c(-c3cccc4ncc(Nc5ccccc5)nc34)cc21 CHEMBL3899005 IC50 1.9 nM
CC1CNC(=O)c2cc(-c3cccc4ncc(Nc5ccccc5)nc34)[nH]c21 CHEMBL3980066 IC50 1.9 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NCC(C)(C)C CHEMBL3940808 IC50 1.9 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)ccc2N)c1N1CC[C@@H](N)C1 CHEMBL3652635 Ki 1.92 nM
Cn1cc(-c2cc3c(-c4cnn(C)c4)n[nH]c3cn2)cn1 CHEMBL3950271 Ki 1.92 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(N5CCC(F)(F)C5)n4)c3c2)o1 CHEMBL3942435 IC50 1.923 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(N5CCC(F)(F)CC5)n4)c3c2)o1 CHEMBL3904783 IC50 1.94 nM
C[C@H]1COCCN1c1ccnc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3937011 IC50 1.955 nM
NC(=O)Nc1cc2c(-c3cccc(N4CCNCC4)n3)n[nH]c2cn1 CHEMBL3634775 Ki 1.96 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1OC1CCNCC1 CHEMBL3652631 Ki 1.97 nM
C[C@@H](O)c1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)C CHEMBL3899014 IC50 1.98 nM
c1cc(C2CC2)nc(-c2c[nH]c3ccc(-c4nnc(NC5CC5)o4)cc23)n1 CHEMBL3924862 IC50 1.994 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccc(O)cc4)cc32)c(=O)[nH]1 CHEMBL585182 Ki 2.0 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccc(N)cc4)cc32)c(=O)[nH]1 CHEMBL574169 Ki 2.0 nM
CN(C)Cc1nc2c(sc3ccc(-c4cccnc4)cc32)c(=O)[nH]1 CHEMBL575461 Ki 2.0 nM
O=c1[nH]c(CNc2cccc(O)c2)nc2c1sc1ccc(-c3ccsc3)cc12 CHEMBL575264 Ki 2.0 nM
O=c1[nH]c(CNc2cccc(O)c2)nc2c1sc1ccc(-c3ccccc3)cc12 CHEMBL573011 Ki 2.0 nM
Clc1cc(OCCN2CCOCC2)ccc1Nc1nc2c(-c3nnc[nH]3)cccc2c2cnccc12 CHEMBL1915448 IC50 2.0 nM
CN1CCN(c2ccc(Nc3nc4c(-c5nnc[nH]5)cccc4c4cnccc34)c(Cl)c2)CC1 CHEMBL1915449 IC50 2.0 nM
Fc1cccc(F)c1Nc1nc2c(-c3nnc[nH]3)cccc2c2cnccc12 CHEMBL1915636 IC50 2.0 nM
Oc1ccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3cnccc23)c(Cl)c1 CHEMBL1915445 IC50 2.0 nM
Fc1ccccc1Nc1nc2c(-c3nnc[nH]3)cccc2c2sccc12 CHEMBL2017324 IC50 2.0 nM
Fc1ccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3sccc23)c(F)c1 CHEMBL2017348 IC50 2.0 nM
COc1ccc2c(c1CN1CCNCC1)O/C(=C\c1c[nH]c3ccccc13)C2=O CHEMBL2147763 IC50 2.0 nM
NCCNc1ccn2ncc(-c3ccc4sccc4c3)c2n1 CHEMBL2442302 IC50 2.0 nM
CN1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(-c4cc(Cl)ccc4F)cn32)C2CCCCC2)CC1 CHEMBL3297764 IC50 2.0 nM
Fc1ccncc1-c1ccc2[nH]nc(-c3cncc(O[C@H]4CNCCC45CC5)n3)c2c1 CHEMBL3393711 IC50 2.0 nM
Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(NC4CCCNC4)n3)c2c1 CHEMBL3393698 IC50 2.0 nM
Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(NC4CCNCC4)n3)c2c1 CHEMBL3393697 IC50 2.0 nM
NC1CCN(c2cncc(-c3n[nH]c4ccc(-c5c(F)cccc5F)cc34)n2)CC1 CHEMBL3393692 IC50 2.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@@H]3CC[C@H](O)[C@H](N)C3)n2)c1F CHEMBL3651937 IC50 2.0 nM
C[C@@H]1C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)C[C@@H](N)[C@H]1O CHEMBL3651991 IC50 2.0 nM
C[C@@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1O CHEMBL3652026 IC50 2.0 nM
N[C@@H]1C[C@H](c2ccncc2NC(=O)c2ccc(F)c(C3CCCCC3)n2)C[C@H](C(F)(F)F)C1 CHEMBL3652005 IC50 2.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3cc(F)ccc3F)n2)C1 CHEMBL3651977 IC50 2.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@H](O)[C@@H](C)C3)n2)c1F CHEMBL3651926 IC50 2.0 nM
CCc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)C[C@H](N)C3)n2)c1F CHEMBL3651917 IC50 2.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2cccc(-c3ccccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3651919 IC50 2.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3cccc(F)c3F)n2)C1 CHEMBL3651975 IC50 2.0 nM
C[C@@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)C[C@@H](N)[C@H]1O CHEMBL3651992 IC50 2.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3cc(C(F)(F)F)ccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3652020 IC50 2.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2cccc(-c3ccc(O)cc3F)n2)C1 CHEMBL3651902 IC50 2.0 nM
C[C@@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](O)[C@H]1O CHEMBL3652030 IC50 2.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2cccc(-c3ccc(O)cc3F)n2)C1 CHEMBL3651933 IC50 2.0 nM
Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1C1=CC(N)CCC1 CHEMBL3652001 IC50 2.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@@H]1O CHEMBL3652024 IC50 2.0 nM
C[C@@H]1CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)C[C@@H](N)[C@H]1O CHEMBL3651997 IC50 2.0 nM
CCCOc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3CC[C@H](O)[C@H](N)C3)ccc2F)c1 CHEMBL3651960 IC50 2.0 nM
Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1C1=CC(N)C(O)CC1 CHEMBL3651987 IC50 2.0 nM
N[C@@H]1C[C@H](c2ccncc2NC(=O)c2cccc(-c3c(F)cccc3F)n2)CC[C@@H]1O CHEMBL3651974 IC50 2.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](O)[C@@H](C)C3)n2)c1F CHEMBL3651927 IC50 2.0 nM
Nc1cc(F)c(-c2ccncc2F)nc1C(=O)Nc1cnccc1[C@@H]1CCC[C@H](N)C1 CHEMBL3652028 IC50 2.0 nM
N[C@@H]1C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3ccccc3F)n2)CC[C@@H]1O CHEMBL3651983 IC50 2.0 nM
CC(=O)O[C@H]1CC[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)C[C@H]1N CHEMBL3651995 IC50 2.0 nM
Nc1cc(-c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)ccn1 CHEMBL3793927 Ki 2.0 nM
Cc1nc2cccc3c2nc1NC/C=C\C[C@@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3808445 IC50 2.0 nM
CN[C@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C1 CHEMBL3912242 IC50 2.0 nM
c1cc(OCC2CCNCC2)c2nc(-c3nnc4ccccn34)ccc2c1 CHEMBL3660019 IC50 2.0 nM
CC(C)COc1cccc2ccc(-c3nnc4cc(CN)ccn34)nc12 CHEMBL3660025 IC50 2.0 nM
CC(C)(C)COc1cccc2ccc(-c3nnc4ccccn34)nc12 CHEMBL3660028 IC50 2.0 nM
CNCC(C)(C)COc1cccc2ccc(-c3nnc4ccccn34)nc12 CHEMBL3660033 IC50 2.0 nM
c1cc(OC2CCCNCC2)c2nc(-c3nnc4ccccn34)ccc2c1 CHEMBL3660050 IC50 2.0 nM
FC1CNCCC1Oc1cccc2ccc(-c3nnc4ccc(C5CC5)cn34)nc12 CHEMBL3660076 IC50 2.0 nM
CN1CCC(F)(COc2cccc3ccc(-c4nnc5ccccn45)nc23)CC1 CHEMBL3660080 IC50 2.0 nM
OCCN1CCC(F)(COc2cccc3ccc(-c4nnc5ccccn45)nc23)CC1 CHEMBL3660081 IC50 2.0 nM
N[C@@H]1CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)CC[C@H]1O CHEMBL3676259 IC50 2.0 nM
N[C@@H]1CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)CC[C@H]1F CHEMBL3676260 IC50 2.0 nM
CC1CC(N)CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676270 IC50 2.0 nM
N[C@@H]1CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)CC(F)(F)C1 CHEMBL3676280 IC50 2.0 nM
C[C@@H]1C[C@H](O)C[C@H](c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676287 IC50 2.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676290 IC50 2.0 nM
N[C@H]1CCCN(c2ccncc2NC(=O)c2csc(-c3ccccc3)n2)C1 CHEMBL3676302 IC50 2.0 nM
NCC[C@H]1CNC(=O)c2cc(-c3cccc(OC(F)(F)F)c3)c(-c3ccc(CN4CCOCC4)cc3)n21 CHEMBL3940702 IC50 2.0 nM
CN(C)Cc1ccc(-c2c(-c3cccc(OC(F)(F)F)c3)cc3n2[C@@H](CCCN)CNC3=O)cc1 CHEMBL3890672 IC50 2.0 nM
O[C@H]1CCN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C[C@@H]1O CHEMBL3892307 IC50 2.0 nM
O=c1[nH]ccc2[nH]c(-c3cccc4ccc(Nc5c(F)cccc5Cl)nc34)cc12 CHEMBL3892866 IC50 2.0 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(NC5CCCCC5)nc34)cc21 CHEMBL3933170 IC50 2.0 nM
Nc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1Oc1ccccc1 CHEMBL3934584 IC50 2.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CNC1 CHEMBL3933668 IC50 2.0 nM
CC1(C)CNCCN1c1cnc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3977800 IC50 2.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1C[C@@H](N(CCF)CCF)C1 CHEMBL3891675 IC50 2.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1C[C@@H](NCC(F)F)C1 CHEMBL3926975 IC50 2.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1C[C@@H](N(C)C)C1 CHEMBL3889998 IC50 2.0 nM
CC(C)(N)[C@H]1CC[C@H](Nc2ccc3ncc(-c4cccc(Cl)c4)n3n2)CC1 CHEMBL3928943 IC50 2.0 nM
O=C1/C(=C/c2c[nH]c3ncccc23)Oc2c1ccc(O)c2CN1CCNCC1 CHEMBL4102902 IC50 2.0 nM
CCOC1CN(c2ccc(Nc3nc4c(-c5nnc[nH]5)cccc4c4cnccc34)c(Cl)c2)CCO1 CHEMBL4102644 IC50 2.0 nM
Nc1ccc(-c2c[nH]c3cc(-c4cncc(O[C@H]5CC[C@H](N)CC5)n4)ccc23)c(F)n1 CHEMBL4087212 IC50 2.0 nM
Nc1ccc(-c2c[nH]c3cc(-c4ccc(N5CCC(N)CC5)cc4)ccc23)c(F)n1 CHEMBL4062679 IC50 2.0 nM
Nc1ccc(-c2c[nH]c3cc(-c4cncc(OC[C@@H](N)c5ccccc5)n4)ccc23)c(F)n1 CHEMBL4090634 IC50 2.0 nM
Nc1ccc(-c2c[nH]c3cc(-c4cncc(N5CCNCC5)n4)ccc23)c(F)n1 CHEMBL4105153 IC50 2.0 nM
CC(C)[C@H](C)COc1cncc(-c2ccc3c(-c4ccc(N)nc4F)c[nH]c3c2)n1 CHEMBL4087294 IC50 2.0 nM
CN1CCC(n2c(I)c(Cl)c3c(Cl)cc(C(N)=O)nc32)CC1 CHEMBL4070019 IC50 2.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCNCC3)c2n1 CHEMBL4077977 IC50 2.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(C#CCN3CCCC3=O)n([C@H]3CCCNC3)c2n1 CHEMBL4446498 IC50 2.0 nM
Cc1cn([C@@H](C)[C@@H]2CCNC[C@@H]2F)c2nc(C(N)=O)cc(Cl)c12 CHEMBL4746428 IC50 2.0 nM
CCN(CC)c1cncc(-c2c[nH]c3ccc(-c4nnc(N)s4)cc23)n1 CHEMBL3892029 IC50 2.004 nM
CN1CCN(c2cccc(-c3c[nH]c4ccc(-c5nnc(N)s5)cc34)n2)CC1 CHEMBL3962808 IC50 2.019 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CC[C@@H](N)C3)n2)cn1 CHEMBL4110731 Ki 2.05 nM
Cn1ncc(NC(=O)c2csc(-c3cccc(C(F)(F)F)n3)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4107108 Ki 2.08 nM
C[C@H]1CN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2CC(F)(F)F)CCN1 CHEMBL3648729 Ki 2.1 nM
NC1CCN(c2cncc(-c3n[nH]c4cnc(-c5cccnc5)cc34)c2)CC1 CHEMBL3894842 Ki 2.1 nM
CN(c1ccccc1)c1ccc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3947727 IC50 2.1 nM
CCCCc1ccc2c(/C=C3\Oc4c(ccc(OC)c4CN4CCNCC4)C3=O)c[nH]c2n1 CHEMBL4073609 IC50 2.1 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(N5CCCCC5)n4)c3c2)o1 CHEMBL3930832 IC50 2.11 nM
CO[C@@H]1[C@H](C)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C)cc3F)n2)C[C@@H]1N CHEMBL3687513 IC50 2.12 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1NS(C)(=O)=O CHEMBL3687438 IC50 2.12 nM
Cn1ncc(NC(=O)c2nc(-c3ccnc(F)c3)sc2N)c1N1CCC[C@H](N)CC1 CHEMBL3648798 Ki 2.12 nM
CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1CO CHEMBL3891786 IC50 2.12 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CC[C@H](N)C3)n2)cn1 CHEMBL3924152 Ki 2.12 nM
C[C@@]1(O)CNCCN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)C1 CHEMBL4109970 Ki 2.16 nM
N[C@H]1CCCN(c2ccccc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C1 CHEMBL3921064 IC50 2.2 nM
CC(C)(COc1cccc2ccc(-c3nnc4ccccn34)nc12)[C@@H](O)CO CHEMBL3664616 IC50 2.2 nM
C[C@]1(N)CCCN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C1 CHEMBL3974415 IC50 2.2 nM
CCN(c1ccccc1)c1cnc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3983065 IC50 2.2 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@@H](C)C1CC1 CHEMBL3980483 IC50 2.2 nM
CN(C)S(=O)(=O)Nc1cccc(-c2nc(/C=C3\SC(=S)NC3=O)cs2)c1 CHEMBL4079975 IC50 2.2 nM
CC(C)(O)C#Cc1c(Cl)c2c(Cl)cc(C(N)=O)nc2n1[C@H]1CCCNC1 CHEMBL4587382 IC50 2.2 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)[C@@H]([C@H](C)O)NC4=O)c2nc1NC1CC1 CHEMBL3939783 IC50 2.26 nM
Cc1nc2cccc(-c3cc4c([nH]3)C(C)(C)NC4=O)c2nc1NC(C)(C)C CHEMBL3897690 IC50 2.28 nM
CCC(CC)(CO)COc1cccc2ccc(-c3nnc4ccccn34)nc12 CHEMBL3664628 IC50 2.3 nM
C[C@@H]1O[C@@H](c2c(NC(=O)c3csc(-c4c(F)cccc4F)n3)cnn2C)C[C@H](N)[C@@]1(C)O CHEMBL3950660 Ki 2.3 nM
COC(C)(C)CC#Cc1c(Cl)c2c(Cl)cc(C(N)=O)nc2n1[C@H]1CCCNC1 CHEMBL4541837 IC50 2.3 nM
NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3COCCO3)n([C@H]3CCCNC3)c2n1 CHEMBL4466764 IC50 2.3 nM
c1cncc(-c2cc3c(-c4cn[nH]c4)n[nH]c3cn2)c1 CHEMBL3967003 Ki 2.31 nM
Cc1nc2cccc(-c3[nH]c4c(c3C)C(=O)NCC4)c2nc1NC(C)(C)C CHEMBL3986680 IC50 2.31 nM
Cc1nc2cccc(-c3cc4c([nH]3)C(CO)NC4=O)c2nc1NC(C)(C)C CHEMBL3936412 IC50 2.32 nM
CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1F CHEMBL3909227 IC50 2.33 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cnc(O)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3920503 Ki 2.37 nM
CC(C)Nc1nnc(-c2cc3c(-c4nccc(C5CC5)n4)c[nH]c3cc2F)o1 CHEMBL3965588 IC50 2.38 nM
N[C@@H]1C=C(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)CC[C@H]1F CHEMBL4109687 IC50 2.4 nM
CC[C@@H]1CNC(=O)c2cc(-c3cccc4ccc(Nc5ccccc5)nc34)[nH]c21 CHEMBL3917922 IC50 2.4 nM
O=C1NC(=S)S/C1=C\c1csc(-c2ccc(O)cc2)n1 CHEMBL4061984 IC50 2.4 nM
CC1(CC#Cc2c(Cl)c3c(Cl)cc(C(N)=O)nc3n2[C@H]2CCCNC2)COC1 CHEMBL4457389 IC50 2.4 nM
c1cc(-c2n[nH]c3cnc(-n4ccnc4)cc23)nc(N2CCCCC2)c1 CHEMBL3895153 Ki 2.41 nM
Fc1ccccc1-c1n[nH]c2cnc(-c3cncc(NC4CCNCC4)c3)cc12 CHEMBL3984278 Ki 2.42 nM
CN(c1ncc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1)C(C)(C)C CHEMBL3982591 IC50 2.43 nM
CC(C)Nc1nc(-c2c[nH]c3ccc(-c4nnc(NC(C)C)o4)cc23)cc(=O)[nH]1 CHEMBL3965556 IC50 2.44 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(NC3CCCCNC3)n2)cn1 CHEMBL3930402 Ki 2.46 nM
CCn1c2cc(Cl)c(O)cc2c(=O)c2c(=O)o[nH]c21 CHEMBL523823 Ki 2.5 nM
C[C@@H]1C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@H](N)[C@@H]1Oc1ccccn1 CHEMBL3687523 IC50 2.5 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)CO CHEMBL3963838 IC50 2.5 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1C[C@@H](O)C1 CHEMBL3977692 IC50 2.5 nM
Cc1nc2cccc(-c3cc4c(s3)C(=O)NC4)c2nc1NC(C)(C)C CHEMBL4527131 IC50 2.5 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(N5CCCCC5)n4)c3c2)s1 CHEMBL3967959 IC50 2.506 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CC(O)C3)n2)cn1 CHEMBL3968874 Ki 2.52 nM
CC(C)Nc1nnc(-c2ccc3[nH]cc(-c4nc(C(N)=O)cc(C5CC5)n4)c3c2)o1 CHEMBL3941198 IC50 2.531 nM
CC(C)(C)Nc1nnc(-c2ccc3[nH]cc(-c4ncc(F)c(C5CC5)n4)c3c2)o1 CHEMBL3978285 IC50 2.531 nM
CC(C)Nc1nnc(-c2ccc3[nH]cc(-c4ncc(F)c(C5CC5)n4)c3c2)o1 CHEMBL3947201 IC50 2.531 nM
Cc1cc(-c2nc(C(=O)Nc3cnn(C)c3N3CC[C@@H](N)[C@H](F)CC3)c(N)s2)cc(C)n1 CHEMBL3648819 Ki 2.54 nM
CC(C)Nc1nnc(-c2ccc3[nH]cc(-c4ccnc(C5CC5)n4)c3c2)o1 CHEMBL3895040 IC50 2.54 nM
CC(C)(C)Nc1ncc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3972296 IC50 2.54 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1NS(C)(=O)=O CHEMBL3687429 IC50 2.56 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Oc5c(F)cccc5F)nc34)cc21 CHEMBL3908049 IC50 2.6 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CCCC(O)C1 CHEMBL3976306 IC50 2.6 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCCNC4=O)c2nc1NC(C)(C)C CHEMBL3907325 IC50 2.6 nM
c1cncc(-c2cc3c(-c4cc[nH]n4)n[nH]c3cn2)c1 CHEMBL3895346 Ki 2.63 nM
Cn1ncc(NC(=O)c2csc(-c3cncc(F)c3)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4108881 Ki 2.66 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)C(F)(F)F CHEMBL3966076 IC50 2.67 nM
Cc1nc2cccc(-c3cc4c([nH]3)C[C@@H](C)NC4=O)c2nc1NC(C)(C)C CHEMBL3959102 IC50 2.69 nM
O[C@@H]1CCN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C[C@H]1O CHEMBL4109810 IC50 2.7 nM
O=c1[nH]cnc2[nH]c(-c3cccc4ccc(Nc5ccccc5)nc34)cc12 CHEMBL3934975 IC50 2.7 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NCC(C)C CHEMBL3970207 IC50 2.7 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3949174 IC50 2.7 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CCCOC1 CHEMBL3980526 IC50 2.7 nM
NC1CCN(c2cc(-c3n[nH]c4cnc(-c5cccnc5)cc34)ccn2)CC1 CHEMBL3933778 Ki 2.78 nM
CCN(CC)CCNc1cncc(-c2ccc3[nH]cc(-c4ccnc(N)n4)c3c2)n1 CHEMBL3264258 IC50 2.8 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Nc5ccc(F)cc5F)nc34)cc21 CHEMBL3977073 IC50 2.8 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(NCc5ccccc5)nc34)cc21 CHEMBL3970144 IC50 2.8 nM
CN(c1ccccc1)c1cnc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3904349 IC50 2.8 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCNCC(C#N)C1 CHEMBL3648777 Ki 2.81 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NCC(F)(F)F CHEMBL3916993 IC50 2.82 nM
C1=C(c2n[nH]c3cnc(-c4cccnc4)cc23)CCC1 CHEMBL3972654 Ki 2.83 nM
N[C@@H]1CCCC[C@H]1Nc1ccn2ncc(-c3ccc4ccccc4c3)c2n1 CHEMBL2442317 IC50 2.9 nM
O[C@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C1 CHEMBL3920197 IC50 2.9 nM
O=C1NC(=S)S/C1=C\c1csc(-c2ccc(OC(F)(F)F)cc2)n1 CHEMBL4104431 IC50 2.9 nM
C[C@]12O[C@H](C[C@H](O)[C@H]1O)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4=O CHEMBL4444272 Kd 2.9 nM
Cc1nc2ccc(F)c(-c3cc(C(N)=O)c(C)[nH]3)c2nc1NC1(C)CC1 CHEMBL3891362 IC50 2.91 nM
CNc1nnc(-c2ccc3[nH]cc(-c4nccc(N5CCC[C@H](N)C5)n4)c3c2)s1 CHEMBL3946212 IC50 2.913 nM
COC1(C)CNCCN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)C1 CHEMBL3914110 Ki 2.94 nM
O=C1CNCCN1c1cccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)n1 CHEMBL3913561 Ki 2.95 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1[S@+](C)[O-] CHEMBL3687442 IC50 2.97 nM
CN(C)Cc1nc2c(sc3ccc(C#CCCCCN4CCCCC4)cc32)c(=O)[nH]1 CHEMBL576734 Ki 3.0 nM
CN(C)Cc1nc2c(sc3ccc(-c4cccc(Cl)c4)cc32)c(=O)[nH]1 CHEMBL582844 Ki 3.0 nM
CN(C)Cc1nc2c(sc3ccc(-c4cc(F)cc(Cl)c4)cc32)c(=O)[nH]1 CHEMBL583385 Ki 3.0 nM
O=c1[nH]c(CN2CC[C@H](O)C2)nc2c1sc1ccc(-c3ccccc3)cc12 CHEMBL572781 Ki 3.0 nM
Clc1ccccc1Nc1nc2c(-c3nnc[nH]3)cccc2c2sccc12 CHEMBL2017323 IC50 3.0 nM
Fc1cccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3sccc23)c1 CHEMBL2017346 IC50 3.0 nM
NCc1ccc(-c2nc3c(oc4ccc(Br)cc43)c(=O)[nH]2)c(Cl)c1 CHEMBL2035626 IC50 3.0 nM
O=C(CCN1CCCCC1)Nc1ccc(-c2nc3c(oc4ccc(Br)cc43)c(=O)[nH]2)c(Cl)c1 CHEMBL2035629 IC50 3.0 nM
CN1C[C@@H]2CC[C@H]1CN2Cc1nc2c(oc3ccc(Br)cc32)c(=O)[nH]1 CHEMBL2035636 IC50 3.0 nM
CN1CCCN(C(=O)c2ccc(F)c(-c3ccc(/C=C4/C(=O)Nc5ccc(Cl)cc54)o3)c2)CC1 CHEMBL2037204 IC50 3.0 nM
COc1ccc2c(c1CN1CCNCC1)O/C(=C\c1n[nH]c3ccccc13)C2=O CHEMBL2147845 IC50 3.0 nM
Nc1ccc(-c2ccccc2C(F)(F)F)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 CHEMBL3103865 Ki 3.0 nM
NC1CCCN(c2cncc(-c3n[nH]c4ccc(-c5c(F)cccc5F)cc34)n2)C1 CHEMBL3393722 IC50 3.0 nM
c1csc(-c2ccc3[nH]nc(-c4cncc(O[C@H]5CNCCC56CC6)n4)c3c2)n1 CHEMBL3393715 IC50 3.0 nM
Fc1ncccc1-c1ccc2[nH]nc(-c3cncc(O[C@H]4CNCCC45CC5)n3)c2c1 CHEMBL3393713 IC50 3.0 nM
CC1(C)CCNCC1Oc1cncc(-c2n[nH]c3ccc(-c4c(F)cccc4F)cc23)n1 CHEMBL3393705 IC50 3.0 nM
C=C1CCNCC1Oc1cncc(-c2n[nH]c3ccc(-c4c(F)cccc4F)cc23)n1 CHEMBL3393703 IC50 3.0 nM
Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(NC4CCNC4)n3)c2c1 CHEMBL3393699 IC50 3.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3ccc(F)cc3F)n2)C1 CHEMBL3651978 IC50 3.0 nM
CCc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@@H]3CC[C@H](O)[C@H](N)C3)n2)c1F CHEMBL3651914 IC50 3.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3cc(O)ccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3651901 IC50 3.0 nM
Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@@H]1CC[C@H](O)[C@@H](N)C1 CHEMBL3651998 IC50 3.0 nM
CCc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@H](O)[C@@H](C)C3)n2)c1F CHEMBL3651911 IC50 3.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c([C@H]3CC[C@@H](O)CC3)n2)C1 CHEMBL3651950 IC50 3.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c([C@H]3CC[C@H](O)CC3)n2)C1 CHEMBL3651951 IC50 3.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2F)C1 CHEMBL3651965 IC50 3.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3ccncc3)n2)C[C@@H](N)[C@@H]1O CHEMBL3652014 IC50 3.0 nM
CCc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@@H]3CCC[C@H](N)C3)n2)c1F CHEMBL3651915 IC50 3.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(C3CCCCC3)ccc2N)C[C@@H](N)[C@@H]1O CHEMBL3639508 IC50 3.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(C3CCCCC3)n2)C1 CHEMBL3651986 IC50 3.0 nM
Nc1cncc(-c2ccncc2NC(=O)c2nc(-c3ccccc3F)ccc2N)n1 CHEMBL3792474 Ki 3.0 nM
CCCCNc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1C CHEMBL3809623 IC50 3.0 nM
OC1CCC(Nc2cccc3ccc(-c4nnc5ccccn45)nc23)CC1 CHEMBL3660008 IC50 3.0 nM
NCCCOc1cccc2ccc(-c3nnc4ccccn34)nc12 CHEMBL3660015 IC50 3.0 nM
F[C@@H]1CNCCC1Oc1cccc2ccc(-c3nnc4ccccn34)nc12 CHEMBL3660031 IC50 3.0 nM
CCNCC(C)(C)COc1cccc2ccc(-c3nnc4ccccn34)nc12 CHEMBL3660032 IC50 3.0 nM
CCC(Oc1cccc2ccc(-c3nnc4ccccn34)nc12)[C@@H](CC)CN CHEMBL3660035 IC50 3.0 nM
FC1CNCCCC1Oc1cccc2ccc(-c3nnc4ccccn34)nc12 CHEMBL3660049 IC50 3.0 nM
FC1CNCCC1Oc1cccc2ccc(-c3nnc4ccc(-c5ccccc5)cn34)nc12 CHEMBL3660078 IC50 3.0 nM
CC1(COc2cccc3ccc(-c4nnc5ccccn45)nc23)CCN(CCO)CC1 CHEMBL3660082 IC50 3.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2csc(-c3c(F)ccc(F)c3F)n2)C1 CHEMBL3676308 IC50 3.0 nM
COc1ccc(-c2c(-c3cccc(OC(F)(F)F)c3)cc3n2[C@@H](CCN)CNC3=O)cc1 CHEMBL3987026 IC50 3.0 nM
CN(C)c1ccc(-c2c(-c3cccc(OC(F)(F)F)c3)cc3n2[C@@H](CCN)CNC3=O)cc1 CHEMBL3951026 IC50 3.0 nM
NCC[C@H]1CNC(=O)c2cc(-c3cccc(OC(F)(F)F)c3)c(-c3cccc(F)c3)n21 CHEMBL3974585 IC50 3.0 nM
COc1ccc(-c2c(-c3cccc(OC(F)(F)F)c3)cc3n2[C@@H](CCN)CNC3=O)cc1Cl CHEMBL3979444 IC50 3.0 nM
O=C1NCCc2[nH]c(-c3c(F)ccc4ccc(Nc5cccnc5)nc34)cc21 CHEMBL3978196 IC50 3.0 nM
CSc1c(Cl)c2c(Cl)cc(C(N)=O)nc2n1C1CCCNC1 CHEMBL4075702 IC50 3.0 nM
NCC1CCC(n2c(I)c(Cl)c3c(Cl)cc(C(N)=O)nc32)CC1 CHEMBL4087517 IC50 3.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(I)n(CCC3CCNCC3)c2n1 CHEMBL4064302 IC50 3.0 nM
CN(C)CCNc1cncc(-c2ccc3[nH]cc(-c4ccnc(N)n4)c3c2)n1 CHEMBL3264257 IC50 3.0 nM
CC(=O)c1ccc(F)c(-c2c[nH]c3ccc(-c4cncc(NCCN(C)C)n4)cc23)c1 CHEMBL4125914 IC50 3.0 nM
CN(C)CCNc1cncc(-c2ccc3[nH]cc(-c4ccc(N)cc4F)c3c2)n1 CHEMBL4129087 IC50 3.0 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CC[C@H](O)C3)n2)cn1 CHEMBL3901533 Ki 3.04 nM
C[C@@H]1C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@H](N)[C@@H]1OCCC#N CHEMBL3687496 IC50 3.08 nM
N[C@H]1CC[C@H](Nc2ccn3ncc(-c4ccc5ccccc5c4)c3n2)CC1 CHEMBL2442316 IC50 3.1 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CC(O)C1 CHEMBL3905697 IC50 3.1 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1SC(C)(C)C CHEMBL3900670 IC50 3.1 nM
Cn1c(Nc2ccccc2)nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2c1=O CHEMBL3913376 IC50 3.1 nM
CC#CCC1CNC(=O)c2cc(-c3cccc4nc(C)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3931746 IC50 3.1 nM
CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1-c1ccccc1 CHEMBL3980680 IC50 3.1 nM
Cc1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccn2c1=O CHEMBL4522524 IC50 3.1 nM
Fc1ccccc1-c1n[nH]c2cnc(-c3cnccc3OC3CNC3)cc12 CHEMBL3968244 Ki 3.12 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cncc3Cl)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4107388 Ki 3.12 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(NC5CCCCC5)n4)c3c2)s1 CHEMBL3394165 IC50 3.15 nM
CC(C)NC(=O)c1ccc(F)c(-c2nc(C(=O)Nc3cnccc3N3CCC[C@H](N)C3)cs2)c1 CHEMBL3676304 IC50 3.2 nM
c1cc2[nH]cc(-c3cncc(C4CC4)n3)c2cc1-c1nnc(NC2COC2)o1 CHEMBL3982185 IC50 3.201 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=S)c2nc1NC(C)(C)C CHEMBL3931370 IC50 3.27 nM
c1cc(-c2n[nH]c3cnc(N4CCOCC4)cc23)nc(N2CCNCC2)c1 CHEMBL3634765 Ki 3.29 nM
CC(C)(COc1cc(F)cc2ccc(-c3nnc4ccccn34)nc12)[C@@H](O)CO CHEMBL3664615 IC50 3.3 nM
CC1CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C(C)CN1 CHEMBL3899655 IC50 3.3 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1OCCC(=O)O CHEMBL3687454 IC50 3.38 nM
Fc1ccccc1-c1n[nH]c2cnc(-c3cnccc3O[C@@H]3CCCNC3)cc12 CHEMBL3634777 Ki 3.4 nM
N[C@H]1C[C@@H](F)CN(c2ccncc2Nc2ncc3ccc(-c4ncccc4F)nn23)C1 CHEMBL4111268 IC50 3.4 nM
CCNc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1C CHEMBL3951627 IC50 3.4 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1C[C@H](O)C1 CHEMBL3974822 IC50 3.4 nM
c1cc2[nH]cc(-c3cncc(C4CC4)n3)c2cc1-c1nnc(NC2CC2)o1 CHEMBL3892732 IC50 3.432 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC(O)CC3)n2)cn1 CHEMBL3892590 Ki 3.47 nM
Brc1c(Br)c(Br)c2[nH]c(NC3CCCNCC3)nc2c1Br CHEMBL3689338 IC50 3.5 nM
CN(C)C(=O)c1ccc(F)c(-c2ccc3cnc(Nc4cnccc4N4CCC[C@H](N)C4)n3n2)c1 CHEMBL3916248 IC50 3.5 nM
CC[C@@H]1C[C@H](N)CC[C@H](c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)O1 CHEMBL4107896 Ki 3.5 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N(C)C(C)(C)C CHEMBL3925198 IC50 3.5 nM
Cc1nc2cccc(-c3cc(C(N)=O)c(C4CC4)[nH]3)c2nc1NC(C)(C)C CHEMBL3915882 IC50 3.52 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cn(C)c(=O)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3969289 Ki 3.53 nM
CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1C#N CHEMBL3926451 IC50 3.55 nM
Cc1cccc(F)c1-c1nc(C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@H](F)CO2)c(C)s1 CHEMBL4108759 Ki 3.59 nM
C[C@H]1[C@@H](N)CCCN1c1ccncc1Nc1ncc2ccc(-c3ncccc3F)nn12 CHEMBL3965074 IC50 3.6 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Oc5cccc(F)c5)nc34)cc21 CHEMBL3950494 IC50 3.6 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(NC5CCCC5)nc34)cc21 CHEMBL3958651 IC50 3.6 nM
CS(=O)(=O)c1ccc(-c2nc(/C=C3\SC(=S)NC3=O)cs2)cc1 CHEMBL4096030 IC50 3.6 nM
N[C@H]1CCC[C@@H](c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C1 CHEMBL3948849 IC50 3.7 nM
COc1nccc(C)c1-c1nc(C(=O)Nc2cnn(C)c2N2CCC[C@H](N)CC2)c(N)s1 CHEMBL3648808 Ki 3.7 nM
C[C@@H]1[C@H](N)CCCN1c1ccncc1Nc1ncc2ccc(-c3c(F)cccc3F)nn12 CHEMBL4115547 IC50 3.7 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CC1 CHEMBL3976162 IC50 3.7 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@H](C)NC4=O)c2nc1NCC(F)F CHEMBL3961097 IC50 3.7 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1CCCCCC1 CHEMBL3648778 Ki 3.73 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCCC3=O)n2)n1 CHEMBL3953849 Ki 3.74 nM
COc1ccc(F)c(-c2n[nH]c3cnc(-c4cnn(C)c4)cc23)c1 CHEMBL3924840 Ki 3.76 nM
N[C@H]1CCN(Cc2nc3c(oc4ccc(Br)cc43)c(=O)[nH]2)C1 CHEMBL2030387 IC50 3.8 nM
Nc1ccc(-c2ccc3cccc(-c4cc5c([nH]4)CCNC5=O)c3n2)c(F)n1 CHEMBL3983324 IC50 3.8 nM
Cc1ccc2c(/C=C3\Oc4c(ccc(O)c4CN4CCNCC4)C3=O)c[nH]c2n1 CHEMBL4084953 IC50 3.8 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@H](CO)NC4=O)c2nc1NC1CC1 CHEMBL3917695 IC50 3.81 nM
FC(F)(F)Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CC4(CNC4)C3)n2)cn1 CHEMBL3899519 Ki 3.81 nM
CN1CCN(c2cccc(-c3c[nH]c4ccc(-c5nnc(N)o5)cc34)n2)CC1 CHEMBL3960298 IC50 3.824 nM
CC(C)c1ccnc(-c2c[nH]c3ccc(-c4nnc(NCC#N)o4)cc23)n1 CHEMBL3956256 IC50 3.83 nM
c1cncc(-c2cc3c(N4CCC(N5CCNCC5)C4)n[nH]c3cn2)c1 CHEMBL3919728 Ki 3.86 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cc(C3COC3)cc(N3CCC[C@H](N)C3)n2)n1 CHEMBL3906127 Ki 3.89 nM
CCN1CCC(F)(COc2cccc3ccc(-c4nnc5ccccn45)nc23)CC1 CHEMBL3660094 IC50 3.9 nM
NC(=O)[C@@H]1CCCN1c1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1 CHEMBL3974232 Ki 3.9 nM
Cc1nnc(-c2nc3cccc(-c4cc5c([nH]4)CCNC5=O)c3nc2NC(C)(C)C)o1 CHEMBL3950282 IC50 3.94 nM
c1cc(-c2n[nH]c3cnc(C4CCCOC4)cc23)nc(N2CCNCC2)c1 CHEMBL3634763 Ki 3.96 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(N)nc(NC(C)(C)C)nc34)[nH]c21 CHEMBL3931685 IC50 3.98 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccccc4)cc32)c(=O)[nH]1 CHEMBL583273 Ki 4.0 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccc(N(C)C)cc4)cc32)c(=O)[nH]1 CHEMBL575255 Ki 4.0 nM
CN(C)Cc1nc2c(sc3ccc(-c4cc(Cl)cc(Cl)c4)cc32)c(=O)[nH]1 CHEMBL575471 Ki 4.0 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccsc4)cc32)c(=O)[nH]1 CHEMBL575263 Ki 4.0 nM
CN(C)Cc1nc2c(sc3ccc(N4CCCC4)cc32)c(=O)[nH]1 CHEMBL573957 Ki 4.0 nM
N#Cc1ccc(-c2ccc3sc4c(=O)[nH]c(CN5CC[C@H](O)C5)nc4c3c2)cc1 CHEMBL573045 Ki 4.0 nM
Oc1ccc(-c2ccc3c(-c4ccc(N5CCNCC5)cc4)c[nH]c3c2)cc1 CHEMBL1910894 IC50 4.0 nM
Fc1cc(OCCN2CCCC2)ccc1Nc1nc2c(-c3nnc[nH]3)cccc2c2cnccc12 CHEMBL1915641 IC50 4.0 nM
FC(F)(F)Oc1cccc(-n2nnc3ccc(NCC4CC5(CCNCC5)C4)nc32)c1 CHEMBL1952126 IC50 4.0 nM
c1ccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3sccc23)cc1 CHEMBL2017322 IC50 4.0 nM
Clc1ccccc1Nc1nc2c(-c3nnc[nH]3)cccc2c2ccsc12 CHEMBL2017328 IC50 4.0 nM
c1ccc(CNc2nc3c(-c4nnc[nH]4)cccc3c3sccc23)cc1 CHEMBL2017336 IC50 4.0 nM
Fc1ccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3sccc23)cc1 CHEMBL2017347 IC50 4.0 nM
COc1ccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3sccc23)cc1 CHEMBL2017352 IC50 4.0 nM
O=C(NCCN1CCCCC1)c1ccc(-c2nc3c(oc4ccc(Br)cc43)c(=O)[nH]2)c(Cl)c1 CHEMBL2035627 IC50 4.0 nM
O=c1[nH]c(-c2ccc(CNC3CCNCC3)cc2Cl)nc2c1oc1ccc(Br)cc12 CHEMBL2035628 IC50 4.0 nM
N[C@@H]1CCCN(c2c(/C=C3\SC(=O)NC3=O)cccc2-c2ccncc2)C1 CHEMBL2048873 IC50 4.0 nM
Nc1ccc(Oc2ccccc2)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 CHEMBL3103859 Ki 4.0 nM
O=C(Nc1cnccc1OC1CCOCC1)c1csc(-c2c(F)cccc2F)n1 CHEMBL3354515 IC50 4.0 nM
O=C(Nc1cnccc1OC1CCNCC1)c1cccc(-c2c(F)cccc2F)n1 CHEMBL3354521 IC50 4.0 nM
Fc1cnccc1-c1ccc2[nH]nc(-c3cncc(O[C@H]4CNCCC45CC5)n3)c2c1 CHEMBL3393712 IC50 4.0 nM
Fc1cccnc1-c1ccc2[nH]nc(-c3cncc(O[C@H]4CNCCC45CC5)n3)c2c1 CHEMBL3393710 IC50 4.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3cccnc3)n2)C[C@@H](N)[C@@H]1O CHEMBL3652012 IC50 4.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2nc(-c3cc(O)ccc3F)ccc2F)C1 CHEMBL3651930 IC50 4.0 nM
N[C@@H]1C[C@H](c2ccncc2NC(=O)c2cccc(-c3ccccc3F)n2)CC[C@@H]1O CHEMBL3651979 IC50 4.0 nM
C[C@@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@H](N)[C@H]1O CHEMBL3652007 IC50 4.0 nM
CCCOc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@@H]3CC[C@H](O)[C@H](N)C3)n2)c1 CHEMBL3651980 IC50 4.0 nM
Nc1ccc(-c2ccncc2NC(=O)c2nc(-c3ccccc3F)ccc2N)cn1 CHEMBL3793600 Ki 4.0 nM
Nc1cc(-c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)ncn1 CHEMBL3793221 Ki 4.0 nM
c1cc(OC2CCNCC2)c2nc(-c3nnc4ccccn34)ccc2c1 CHEMBL3660014 IC50 4.0 nM
CN(C)CC(C)(C)COc1cccc2ccc(-c3nnc4ccccn34)nc12 CHEMBL3660026 IC50 4.0 nM
F[C@H]1CNCCC1Oc1cccc2ccc(-c3nnc4ccccn34)nc12 CHEMBL3660030 IC50 4.0 nM
CCC(Oc1cccc2ccc(-c3nnc4ccccn34)nc12)[C@H](CC)CN CHEMBL3660036 IC50 4.0 nM
CC[C@@H](CN)C(C)Oc1cccc2ccc(-c3nnc4ccccn34)nc12 CHEMBL3660037 IC50 4.0 nM
NCC(F)(F)COc1cccc2ccc(-c3nnc4ccccn34)nc12 CHEMBL3660043 IC50 4.0 nM
COC[C@@H]1CC(Oc2cccc3ccc(-c4nnc5ccccn45)nc23)CCN1 CHEMBL3660054 IC50 4.0 nM
NC(=O)CN1CCC(F)(COc2cccc3ccc(-c4nnc5ccccn45)nc23)CC1 CHEMBL3660079 IC50 4.0 nM
N[C@H]1C[C@@H](F)CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676267 IC50 4.0 nM
N[C@H]1C[C@H](F)CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676273 IC50 4.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3676297 IC50 4.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1F CHEMBL3676311 IC50 4.0 nM
CSc1ncc2ccc3c(C(N)=O)c(C)n(C(C)C)c3c2n1 CHEMBL3703181 IC50 4.0 nM
CN(C)Cc1ccc(-c2c(-c3cccc(OC(F)(F)F)c3)cc3n2C(CCOC(=O)C(F)(F)F)CNC3=O)cc1 CHEMBL3966701 IC50 4.0 nM
NCCC1CNC(=O)c2cc(-c3cccc(OC(F)(F)F)c3)c(-c3ccc(CO)cc3)n21 CHEMBL3980874 IC50 4.0 nM
NCCC[C@H]1CNC(=O)c2cc(-c3cccc(OC(F)(F)F)c3)c(-c3ccc(O)cc3)n21 CHEMBL3898204 IC50 4.0 nM
O=c1[nH]cnc2[nH]c(-c3cccc4ccc(Nc5ccc(Cl)cc5)nc34)cc12 CHEMBL3973961 IC50 4.0 nM
C[C@H](O)c1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)C CHEMBL3923557 IC50 4.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1N[C@H]1CCC[C@@H](NS(C)(=O)=O)C1 CHEMBL3907991 IC50 4.0 nM
CC(C)(O)[C@H]1CC[C@H](Nc2ccc3ncc(-c4cccc(Cl)c4)n3n2)CC1 CHEMBL3938841 IC50 4.0 nM
N[C@H]1CC[C@H](Nc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1 CHEMBL3973281 IC50 4.0 nM
N[C@H]1CC[C@H](Nc2ccc3ncc(-c4cccc(Cl)c4)n3n2)CC1 CHEMBL3947323 IC50 4.0 nM
CCOC1CCCN1c1ccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3cnccc23)c(F)c1 CHEMBL4073348 IC50 4.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(C3CC3)n([C@@H]3CCCNC3)c2n1 CHEMBL4086461 IC50 4.0 nM
CC(C)=Cc1c(Cl)c2c(Cl)cc(C(N)=O)nc2n1C1CCCNC1 CHEMBL4071926 IC50 4.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(I)n(CC3CCNCC3)c2n1 CHEMBL4072887 IC50 4.0 nM
CN1CCOc2c1cnn1c(-c3ccc4ccnc(NCC5CCNCC5)c4c3)nnc21 CHEMBL4555990 IC50 4.0 nM
CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1N1CC(O)C1 CHEMBL3966109 IC50 4.07 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Oc5cccc(O)c5)nc34)cc21 CHEMBL3972504 IC50 4.1 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(C5(c6ccccc6)CC5)nc34)cc21 CHEMBL3966443 IC50 4.1 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1C[C@H](NC(=O)OC(C)(C)C)C1 CHEMBL3891457 IC50 4.1 nM
O=C1N(CC2CCNC2)CCN1c1n[nH]c2cnc(-c3cccnc3)cc12 CHEMBL3936994 Ki 4.11 nM
CC(C)Oc1cccc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3901441 IC50 4.147 nM
CC(C)Nc1nccc(-c2c[nH]c3ccc(-c4nnc(NC(C)C)o4)cc23)n1 CHEMBL3950988 IC50 4.15 nM
c1cc2[nH]cc(-c3cncc(C4CC4)n3)c2cc1-c1nnc(N2CCNCC2)o1 CHEMBL3927004 IC50 4.192 nM
CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1C(F)(F)F CHEMBL3916196 IC50 4.2 nM
Cn1ncc(NC(=O)c2nc(-c3cncc(F)c3)sc2N)c1N1CCC[C@H](N)CC1 CHEMBL3648801 Ki 4.25 nM
CC(C)Nc1cncc(-c2c[nH]c3ccc(-c4nc(N)ns4)cc23)n1 CHEMBL3944528 IC50 4.263 nM
COCC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1C CHEMBL3965003 IC50 4.3 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NCC(C)(C)N CHEMBL3980532 IC50 4.3 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(C5CC5)n4)c3c2)o1 CHEMBL3896794 IC50 4.344 nM
C[C@@H]1O[C@H](c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC(F)(F)[C@]1(C)N CHEMBL3909959 Ki 4.35 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)ccc2N)c1OC1CCNCC1 CHEMBL3652629 Ki 4.36 nM
Cc1noc(C)c1-c1nc(C(=O)Nc2cnn(C)c2N2CCC[C@H](N)CC2)c(N)s1 CHEMBL3648802 Ki 4.37 nM
Fc1cc(OC2CCNCC2(F)F)c2nc(-c3nnc4ccccn34)ccc2c1 CHEMBL3660087 IC50 4.4 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(NC5CCOCC5)nc34)cc21 CHEMBL3925557 IC50 4.4 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCC4(CN(C=O)C4)C3)n2)n1 CHEMBL3972017 Ki 4.41 nM
Cc1cn(-c2cccc(-c3c[nH]c4ccc(-c5nnc(N)s5)cc34)n2)cn1 CHEMBL3901582 IC50 4.424 nM
CCn1cc(-c2cc3c(-c4ccc(=O)n(CC5(C(N)=O)CCC5)c4)n[nH]c3cn2)cn1 CHEMBL4108317 Ki 4.49 nM
NCCNc1ccn2ncc(-c3cccc(-c4ccco4)c3)c2n1 CHEMBL2442290 IC50 4.5 nM
N[C@H]1CCCN(c2ccncc2Nc2nnc3ccc(-c4c(F)cccc4F)nn23)C1 CHEMBL3914834 IC50 4.5 nM
Cc1cc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1Nc1ccc(Br)cc1 CHEMBL3900533 IC50 4.5 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N(C)C(C)C CHEMBL3891287 IC50 4.5 nM
CCCc1ccc2c(/C=C3\Oc4c(ccc(OC)c4CN4CCNCC4)C3=O)c[nH]c2n1 CHEMBL4094705 IC50 4.5 nM
C[C@H]1NC(=O)c2cc(-c3nccc4c(=O)n(C)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4530924 IC50 4.5 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1NCC1CCNCC1 CHEMBL3652622 Ki 4.54 nM
CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1N1CCC1 CHEMBL3894757 IC50 4.55 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(NC5CC5)n4)c3c2)s1 CHEMBL3986124 IC50 4.572 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Oc5c(F)cccc5Cl)nc34)cc21 CHEMBL3944428 IC50 4.6 nM
c1ccc(-c2n[nH]c3cnc(-c4cn[nH]c4)cc23)cc1 CHEMBL3983797 Ki 4.61 nM
Nc1nnc(-c2ccc3[nH]cc(-c4nccc(OCC(F)(F)F)n4)c3c2)o1 CHEMBL3971664 IC50 4.681 nM
COc1ccc2nnc(-c3ccc4cccc(OCC5(F)CCNCC5)c4n3)n2c1 CHEMBL3664612 IC50 4.7 nM
C=C(c1ccccc1)c1ccc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3964505 IC50 4.7 nM
CC1(C)CN(c2cnc3cccc(-c4cc5c([nH]4)CCNC5=O)c3n2)CCN1 CHEMBL3948083 IC50 4.7 nM
CC(C)(CC#Cc1c(Cl)c2c(Cl)cc(C(N)=O)nc2n1[C@H]1CCCNC1)C(N)=O CHEMBL4533366 IC50 4.7 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1F CHEMBL3938145 Ki 4.77 nM
Cc1n[nH]c2cnc(-c3cncc(N4CCC[C@H](N)C4)n3)cc12 CHEMBL3912557 Ki 4.78 nM
Fc1ccc2nnc(-c3ccc4cccc(OC5CCNCCC5F)c4n3)n2c1 CHEMBL3660092 IC50 4.9 nM
NCC1(COc2cccc3ccc(-c4nnc5ccccn45)nc23)CCCC1 CHEMBL3664626 IC50 4.9 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Sc5ccccc5)nc34)cc21 CHEMBL3976993 IC50 4.9 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CCCCC1O CHEMBL3964978 IC50 4.9 nM
O=C1N=C(NCC2CCN(CCO)CC2)S/C1=C\c1csc(-c2ccccc2O)n1 CHEMBL4794742 IC50 4.9 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H](C)C(F)(F)F CHEMBL3978345 IC50 4.97 nM
O=c1[nH]c(CN2CC[C@H](O)C2)nc2c1sc1ccc(Cl)cc12 CHEMBL572513 Ki 5.0 nM
CN(C)Cc1nc2c(sc3ccc(Br)cc32)c(=O)[nH]1 CHEMBL575470 Ki 5.0 nM
C#Cc1ccc2sc3c(=O)[nH]c(CN(C)C)nc3c2c1 CHEMBL574168 Ki 5.0 nM
CN(C)Cc1nc2c(sc3ccc(-c4cccc(OC(F)(F)F)c4)cc32)c(=O)[nH]1 CHEMBL573923 Ki 5.0 nM
CCc1ccc(-c2ccc3sc4c(=O)[nH]c(CN(C)C)nc4c3c2)cc1 CHEMBL572550 Ki 5.0 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccc(C#N)cc4)cc32)c(=O)[nH]1 CHEMBL573702 Ki 5.0 nM
O=c1[nH]c(CN2CC[C@H](O)C2)nc2c1sc1ccc(-c3ccsc3)cc12 CHEMBL573012 Ki 5.0 nM
Fc1ccccc1Nc1nc2c(-c3nnc[nH]3)cccc2c2cnccc12 CHEMBL1915442 IC50 5.0 nM
CN(C)c1cccc(-n2nnc3ccc(NCC4CCNCC4)nc32)c1 CHEMBL1952134 IC50 5.0 nM
COc1cccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3sccc23)c1Cl CHEMBL2017343 IC50 5.0 nM
NC(=O)c1cccc2c1nc(Nc1ccccc1Cl)c1ccsc12 CHEMBL2017359 IC50 5.0 nM
CNC(=O)c1cccc2c1nc(Nc1ccccc1Cl)c1ccsc12 CHEMBL2017360 IC50 5.0 nM
O=c1[nH]c(CN2CC[C@@H](O)C2)nc2c1oc1ccc(Br)cc12 CHEMBL2030386 IC50 5.0 nM
CN1CCCN(C(=O)c2cccc(-c3ccc(/C=C4/C(=O)Nc5ccc(Cl)cc54)o3)c2)CC1 CHEMBL2037200 IC50 5.0 nM
O=C1Nc2ccc(Cl)cc2/C1=C\c1ccc(-c2cccc(C(=O)N3CCCNCC3)c2)o1 CHEMBL2037201 IC50 5.0 nM
CN(C)CCNc1ccn2ncc(-c3ccc4ccccc4c3)c2n1 CHEMBL2442300 IC50 5.0 nM
CN1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(-c4cccc(Cl)c4)cn32)C(C)(C)C)CC1 CHEMBL3297767 IC50 5.0 nM
O=C(Nc1cnccc1O[C@H]1CCNC1)c1csc(-c2c(F)cccc2F)n1 CHEMBL3354511 IC50 5.0 nM
N[C@H]1CC[C@H](Nc2ccn3ncc(-c4cccc(OC(F)(F)F)c4)c3n2)CC1 CHEMBL3355542 IC50 5.0 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(N5CCOCC5)n4)c3c2)s1 CHEMBL3394073 IC50 5.0 nM
Nc1ccc(C2CCCCC2)nc1C(=O)Nc1cnccc1[C@@H]1CCC[C@H](N)C1 CHEMBL3652000 IC50 5.0 nM
CCCNc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1C CHEMBL3808459 IC50 5.0 nM
c1cc(N[C@@H]2CCNC2)c2nc(-c3nnc4ccccn34)ccc2c1 CHEMBL3660010 IC50 5.0 nM
NCCCNc1cccc2ccc(-c3nnc4ccccn34)nc12 CHEMBL3660012 IC50 5.0 nM
OCC1(COc2cccc3ccc(-c4nnc5ccccn45)nc23)CC1 CHEMBL3660027 IC50 5.0 nM
c1cc(OC2CC3CCC(C2)N3)c2nc(-c3nnc4ccccn34)ccc2c1 CHEMBL3660034 IC50 5.0 nM
CC[C@H](CN)C(C)Oc1cccc2ccc(-c3nnc4ccccn34)nc12 CHEMBL3660038 IC50 5.0 nM
COC1CCN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)CC1N CHEMBL3676263 IC50 5.0 nM
NC1CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)CCC1Cl CHEMBL3676274 IC50 5.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1O CHEMBL3676299 IC50 5.0 nM
CSc1ncc2c(n1)-c1c(c(C(N)=O)cn1[C@H]1CC[C@@H](N)CC1)CC2 CHEMBL3703183 IC50 5.0 nM
Cc1cccc(-c2c(-c3cccc(OC(F)(F)F)c3)cc3n2[C@@H](CCN)CNC3=O)c1 CHEMBL3935063 IC50 5.0 nM
COC[C@@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3922440 IC50 5.0 nM
O[C@H]1CC[C@H](Nc2ccc3ncc(-c4cccc(C(F)(F)F)c4)n3n2)CC1 CHEMBL3979144 IC50 5.0 nM
O=C1NC(=S)S/C1=C\c1csc(-c2cccc(O)c2)n1 CHEMBL4083726 IC50 5.0 nM
NCCNc1cncc(-c2ccc3[nH]cc(-c4ccccc4F)c3c2)n1 CHEMBL4125725 IC50 5.0 nM
CN(C)CCNc1cncc(-c2ccc3[nH]cc(-c4ccc(N)c(C#N)c4)c3c2)n1 CHEMBL4126750 IC50 5.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccnc(-c3c(F)cccc3F)n2)C[C@@H](O)[C@]1(C)O CHEMBL4791128 Ki 5.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(OC(F)(F)F)c4)c3)cc12 CHEMBL1965836 pKi 5.012 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 5.012 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(C3(O)CCCNCC3)n2)cn1 CHEMBL3959083 Ki 5.05 nM
CNc1nnc(-c2ccc3[nH]cc(-c4cncc(N5CCCCC5)n4)c3c2)s1 CHEMBL3930004 IC50 5.069 nM
NCCCNc1ccn2ncc(-c3ccc4ccccc4c3)c2n1 CHEMBL2442299 IC50 5.1 nM
Cc1nc2cccc(-c3cc4c(=O)[nH]cnc4[nH]3)c2nc1NC(C)(C)CO CHEMBL3940464 IC50 5.1 nM
Nc1nnc(-c2ccc3[nH]cc(-c4nccc(C5CC5)n4)c3c2)o1 CHEMBL3893588 IC50 5.189 nM
O=c1[nH]ccc2[nH]c(-c3cccc4ccc(Nc5ccccc5Cl)nc34)cc12 CHEMBL3915285 IC50 5.2 nM
O=C1N=C(N[C@H]2CCC[C@@H]2CO)S/C1=C\c1csc(-c2cccc(F)c2O)n1 CHEMBL4747343 IC50 5.2 nM
N[C@@H]1CCCC[C@H]1Nc1nc2c(Br)c(Br)c(Br)c(Br)c2[nH]1 CHEMBL3689321 IC50 5.26 nM
N#Cc1cc(-c2n[nH]c3cnc(-c4cccnc4)cc23)cc(N2CCNCC2)c1 CHEMBL3906142 Ki 5.28 nM
OC1(COc2cccc3ccc(-c4nnc5ccccn45)nc23)CCNCC1 CHEMBL3660068 IC50 5.3 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CCCCC1 CHEMBL3986516 IC50 5.3 nM
CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1C=O CHEMBL3891942 IC50 5.3 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccnc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1S(C)(=O)=O CHEMBL3687514 IC50 5.35 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@H](COCc3ccccc3)NC4=O)c2nc1NC(C)(C)C CHEMBL3899420 IC50 5.4 nM
Cc1nc2cccc(-c3cc4c(=O)[nH]ncc4[nH]3)c2nc1NC(C)(C)C CHEMBL3953807 IC50 5.44 nM
CC(C)(CNCC(F)(F)F)COc1cccc2ccc(-c3nnc4ccccn34)nc12 CHEMBL3664633 IC50 5.5 nM
C[C@H]1CCCN(c2ccnc(-c3c[nH]c4ccc(-c5nnc(N)o5)cc34)n2)C1 CHEMBL3970168 IC50 5.5 nM
Cn1cc(-c2cc3c(-c4ccccc4)n[nH]c3cn2)cn1 CHEMBL3966229 Ki 5.57 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CC(CN)C3)n2)cn1 CHEMBL3913945 Ki 5.58 nM
CC(C)Oc1cncc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3965218 IC50 5.589 nM
N[C@H]1CCCN(c2ccncc2Nc2nnc3ccc(-c4ncccc4F)nn23)C1 CHEMBL3919837 IC50 5.6 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C)c(N3CCC[C@H](N)C3=O)n2)n1 CHEMBL3952989 Ki 5.61 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNC3=O)n2)n1 CHEMBL3892308 Ki 5.67 nM
Cn1ncc(NC(=O)c2csc(-c3cncc(F)c3)n2)c1[C@@H]1CC[C@@H](N)[C@@H](F)CO1 CHEMBL3941854 Ki 5.76 nM
CCc1nc(-c2c[nH]c3ccc(-c4nnc(NC(C)(C)C)o4)cc23)ncc1F CHEMBL3918188 IC50 5.795 nM
CC(C)Nc1cncc(-c2c[nH]c3ccc(-c4nc(N)no4)cc23)n1 CHEMBL3954270 IC50 5.795 nM
CN1CCCC(Oc2ccnc(-c3c[nH]c4ccc(-c5nnc(N)o5)cc34)n2)C1 CHEMBL3912113 IC50 5.795 nM
CCC(CO)COc1cccc2ccc(-c3nnc4ccccn34)nc12 CHEMBL3664627 IC50 5.8 nM
Cc1n[nH]c2cnc(-c3cncc(N4CCC(N)CC4)n3)cc12 CHEMBL3634778 Ki 5.8 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CCCC1 CHEMBL3925905 IC50 5.8 nM
CC(C)(C#N)CC#Cc1c(Cl)c2c(Cl)cc(C(N)=O)nc2n1[C@H]1CCCNC1 CHEMBL4445116 IC50 5.8 nM
CN1CCCC(Nc2nc3c(Br)c(Br)c(Br)c(Br)c3[nH]2)CC1 CHEMBL3689337 IC50 5.82 nM
Cc1nc2cccc(-c3cc4c([nH]3)C[C@H](C)NC4=O)c2nc1NC(C)(C)C CHEMBL3930939 IC50 5.85 nM
C[C@@H]1C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@H](N)C12OCCO2 CHEMBL3687453 IC50 5.86 nM
NCCCNc1nc2c(Br)c(Br)c(Br)c(Br)c2[nH]1 CHEMBL2159217 IC50 5.89 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Oc5ccccc5)nc34)cc21 CHEMBL3966805 IC50 5.9 nM
Cc1nc2cccc(-c3cc4n(c3)CCNC4=O)c2nc1NC(C)(C)C CHEMBL3913500 IC50 5.9 nM
Cn1ncc(NC(=O)c2csc(-c3cccc4cnn(C)c34)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4113518 Ki 5.91 nM
CC(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2c(=O)n1-c1ccccc1 CHEMBL3892102 IC50 5.91 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cccc(N5CCOCC5)n4)c3c2)o1 CHEMBL3890347 IC50 5.913 nM
CC1CCCCN1c1ccnc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3932794 IC50 5.949 nM
Cc1noc(C)c1-c1nc(C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@@H](F)CO2)cs1 CHEMBL3914906 Ki 5.98 nM
CN(C)[C@H]1CCCN(c2ccnc(-c3c[nH]c4ccc(-c5nnc(N)o5)cc34)n2)C1 CHEMBL3973417 IC50 5.982 nM
CN(C)Cc1nc2c(sc3ccc(-c4cccc(F)c4)cc32)c(=O)[nH]1 CHEMBL573705 Ki 6.0 nM
Cc1ccc(F)cc1Nc1nc2c(-c3nnc[nH]3)cccc2c2cnccc12 CHEMBL1915635 IC50 6.0 nM
FC(F)(F)Oc1cccc(-n2nnc3ccc(NCC4CCNCC4)nc32)c1 CHEMBL1952113 IC50 6.0 nM
FC(F)(F)Oc1cccc(-n2nnc3cc(Cl)c(NCC4CCNCC4)nc32)c1 CHEMBL1952144 IC50 6.0 nM
Clc1cccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3sccc23)c1 CHEMBL2017339 IC50 6.0 nM
C#Cc1cccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3sccc23)c1 CHEMBL2017356 IC50 6.0 nM
N[C@@H]1CCN(Cc2nc3c(oc4ccc(Br)cc43)c(=O)[nH]2)C1 CHEMBL2030388 IC50 6.0 nM
CCOc1ccc2c(c1CN1CCNCC1)O/C(=C\c1c[nH]c3ccccc13)C2=O CHEMBL2147764 IC50 6.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2F)C1 CHEMBL3651976 IC50 6.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3cc(F)cc(F)c3F)n2)C1 CHEMBL3651910 IC50 6.0 nM
Nc1nccc(-c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)n1 CHEMBL3793267 Ki 6.0 nM
N[C@@H]1C[C@@H](C(F)(F)F)CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676282 IC50 6.0 nM
N[C@@H]1C[C@H](c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)CC[C@@H]1O CHEMBL3676293 IC50 6.0 nM
CN(C)C1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(-c4ccnc(F)c4)cn32)C2CCCCC2)CC1 CHEMBL3961921 IC50 6.0 nM
CN(C)CCNC(=O)c1ccc(-c2c(-c3cccc(OC(F)(F)F)c3)cc3n2C(CCO)CNC3=O)cc1 CHEMBL3984169 IC50 6.0 nM
CC(=O)c1ccc(-c2c(-c3cccc(OC(F)(F)F)c3)cc3n2[C@@H](CCN)CNC3=O)cc1 CHEMBL3970295 IC50 6.0 nM
NCC[C@H]1CNC(=O)c2cc(-c3cccc(OC(F)(F)F)c3)c(-c3ccc4c(c3)OCO4)n21 CHEMBL3905102 IC50 6.0 nM
NC(=O)c1ccnc(-c2n[nH]c3cnc(-c4cccnc4)cc23)c1 CHEMBL3987002 Ki 6.0 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(OC5CCNCC5)nc34)cc21 CHEMBL3904025 IC50 6.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1C[C@@H](N2CCOCC2)C1 CHEMBL3918021 IC50 6.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CN4CCC3CC4)c2n1 CHEMBL4105379 IC50 6.0 nM
CN1CCOc2c1cnn1c(-c3ccc4cccc(NCC5CCNCC5)c4c3)nnc21 CHEMBL4440880 IC50 6.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1-c1c(F)cccc1Cl CHEMBL3901445 IC50 6.04 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(-c5cccc(F)c5)n4)c3c2)o1 CHEMBL3981344 IC50 6.067 nM
Cc1ccc(F)c(-c2n[nH]c3cnc(-c4cnn(C)c4)cc23)c1 CHEMBL3925376 Ki 6.08 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Oc5ccccc5F)nc34)cc21 CHEMBL3953144 IC50 6.1 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@@H]1CCNC1 CHEMBL3914616 IC50 6.1 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)C(N)=O CHEMBL3981216 IC50 6.2 nM
C[C@@H]1C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@H](N)[C@@H]1OCCC#N CHEMBL3687473 IC50 6.3 nM
CC1Cc2[nH]c(-c3cccc4ccc(Nc5ccccc5)nc34)cc2C(=O)N1 CHEMBL3946958 IC50 6.3 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Oc5cccnc5)nc34)cc21 CHEMBL3975293 IC50 6.3 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccc(Cl)c(Cl)c4)c3)cc12 CHEMBL1991063 pKi 6.31 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@H](C)NC4=O)c2nc1NCC(F)(F)F CHEMBL3965960 IC50 6.37 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(N[C@@H]5CCCNC5)nc34)cc21 CHEMBL3921312 IC50 6.4 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CCOC1 CHEMBL3979545 IC50 6.4 nM
Cc1nc2cccc(-c3cc4c(s3)CNC4=O)c2nc1NC(C)(C)C CHEMBL4514782 IC50 6.4 nM
CC1CCCN1c1ccnc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3971473 IC50 6.419 nM
c1cncc(-c2cc3c(-c4cccnc4)n[nH]c3cn2)c1 CHEMBL3972762 Ki 6.46 nM
CNc1nnc(-c2ccc3[nH]cc(-c4cccc(OC(C)C)n4)c3c2)o1 CHEMBL3942256 IC50 6.48 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cn[nH]c1N1CCC[C@H](N)C1 CHEMBL3652621 Ki 6.5 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(CO)CCC1 CHEMBL3916316 IC50 6.5 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c3N=C(NC(C)(C)C)N(C)S4(=O)=O)[nH]c21 CHEMBL4546373 IC50 6.5 nM
CCn1c(N2CCNCC2)nc2c(Br)c(Br)c(Br)c(Br)c21 CHEMBL3684952 IC50 6.55 nM
C[C@H]1CC[C@@H](N)CN1c1ccncc1Nc1ncc2ccc(-c3c(F)cccc3F)nn12 CHEMBL3925861 IC50 6.6 nM
Brc1c(Br)c(Br)c2[nH]c(NC3CCNCC3)nc2c1Br CHEMBL3689342 IC50 6.68 nM
C[C@@H]1CN[C@@H](C)CN1c1ccncc1Nc1ncc2ccc(-c3c(F)cccc3F)nn12 CHEMBL3920138 IC50 6.7 nM
O=C1NCCn2cc(-c3cccc4ccc(Nc5ccccc5)nc34)cc21 CHEMBL3897895 IC50 6.7 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NCC1(C)COC1 CHEMBL3894496 IC50 6.7 nM
O=C1NC(=S)S/C1=C\c1csc(-c2ccco2)n1 CHEMBL4087322 IC50 6.7 nM
O=C1NC(=S)S/C1=C\c1csc(-c2ccccc2)n1 CHEMBL4069560 IC50 6.7 nM
N=C(N)N1CCN(c2nc3c(Br)c(Br)c(Br)c(Br)c3[nH]2)CC1 CHEMBL3684951 IC50 6.72 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(O[C@@H]5CCCNC5)n4)c3c2)o1 CHEMBL4108940 IC50 6.771 nM
O=Cc1c[nH]c2c1ccc1c2[nH]c2cccc(Br)c21 CHEMBL1240961 IC50 6.8 nM
c1ccc2cc(-c3cnn4ccc(N5CCNCC5)nc34)ccc2c1 CHEMBL2442295 IC50 6.8 nM
C[C@@H]1C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@H](N)[C@@H]1N=[N+]=[N-] CHEMBL3687439 IC50 6.8 nM
O=C1NC(=S)S/C1=C\c1csc(-c2ccc(CN3CCCCC3)cc2)n1 CHEMBL4074078 IC50 6.8 nM
CC(C)n1c(N2CCNCC2)nc2c(Br)c(Br)c(Br)c(Br)c21 CHEMBL3684943 IC50 6.84 nM
Nc1nnc(-c2ccc3[nH]cc(-c4nccc(-c5ccccc5)n4)c3c2)o1 CHEMBL3965031 IC50 6.846 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC2(CCNC2)C1 CHEMBL3648765 Ki 6.85 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)CN CHEMBL3969013 IC50 6.85 nM
NC1CCCCC1Nc1nc2c(Br)c(Br)c(Br)c(Br)c2[nH]1 CHEMBL3689320 IC50 6.9 nM
O=C1NCCc2[nH]c(-c3cccc4cnc(C5(c6ccccc6)CC5)nc34)cc21 CHEMBL3945081 IC50 6.9 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1CC(C)(C)C CHEMBL3975613 IC50 6.9 nM
CC(C)(CO)CNC1=NC(=O)/C(=C/c2csc(-c3cc(F)ccc3O)n2)S1 CHEMBL4778893 IC50 6.9 nM
CC(C)Nc1ccnc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3908000 IC50 6.905 nM
Cc1n[nH]c2cnc(-c3cncc(N4CCC[C@@H](N)C4)n3)cc12 CHEMBL4107866 Ki 6.91 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)nc1 CHEMBL3922627 Ki 6.92 nM
Cc1ccccc1Nc1nc2c(-c3nnc[nH]3)cccc2c2cnccc12 CHEMBL1915443 IC50 7.0 nM
Cc1cc(F)ccc1Nc1nc2c(-c3nnc[nH]3)cccc2c2cnccc12 CHEMBL1915634 IC50 7.0 nM
COCCOc1ccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3cnccc23)c(F)c1 CHEMBL1915640 IC50 7.0 nM
CN(C)CCOc1ccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3cnccc23)c(F)c1 CHEMBL1915642 IC50 7.0 nM
CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1 CHEMBL1952141 IC50 7.0 nM
CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1 CHEMBL1952329 IC50 7.0 nM
Clc1ccccc1Nc1nc2c(-c3nnc[nH]3)cccc2c2cscc12 CHEMBL2017326 IC50 7.0 nM
COc1ccccc1Nc1nc2c(-c3nnc[nH]3)cccc2c2sccc12 CHEMBL2017350 IC50 7.0 nM
O=c1[nH]c(-c2ccc(NCC3CCNCC3)cc2)nc2c1oc1ccc(Br)cc12 CHEMBL2035630 IC50 7.0 nM
NCCNc1ccn2ncc(-c3ccc4scnc4c3)c2n1 CHEMBL2442303 IC50 7.0 nM
CN(C)CCNc1ccn2ncc(-c3cn[nH]c3)c2n1 CHEMBL2442287 IC50 7.0 nM
Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(OC4CCCNC4)n3)c2c1 CHEMBL3393702 IC50 7.0 nM
Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(N4CCNCC4)n3)c2c1 CHEMBL3393695 IC50 7.0 nM
CC(C)Oc1cccc(-c2c[nH]c3ccc(-c4nnc(N)s4)cc23)n1 CHEMBL3394167 IC50 7.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2cccc(-c3cc(F)cc(F)c3F)n2)C1 CHEMBL3651944 IC50 7.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3ccc(O)cc3F)ccc2F)C1 CHEMBL3651935 IC50 7.0 nM
CSc1ncc2ccc3c(C(N)=O)cn(C4CCNCC4)c3c2n1 CHEMBL3703185 IC50 7.0 nM
NCCC1CNC(=O)c2cc(-c3cccc(OC(F)(F)F)c3)c(-c3ccccc3)n21 CHEMBL3921910 IC50 7.0 nM
NC(=O)c1ccc(-c2c(-c3cccc(OC(F)(F)F)c3)cc3n2C(CCO)CNC3=O)cc1 CHEMBL3953089 IC50 7.0 nM
NCC[C@H]1CNC(=O)c2cc(-c3cccc(OC(F)(F)F)c3)c(-c3ccc(C=O)cc3)n21 CHEMBL3925205 IC50 7.0 nM
Nc1cc(-c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)ccn1 CHEMBL3922101 IC50 7.0 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(N[C@H]5CC[C@H](O)CC5)nc34)cc21 CHEMBL3974903 IC50 7.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCN(CO)C4=O)c2nc1NC(C)(C)C CHEMBL3894660 IC50 7.0 nM
O[C@H]1CC[C@H](Nc2ccc3ncc(-c4cccc(Cl)c4)n3n2)CC1 CHEMBL3964407 IC50 7.0 nM
O[C@H]1CC[C@H](Oc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1 CHEMBL3929683 IC50 7.0 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1 CHEMBL3301610 Kd apparent 7.0 nM
O=C1NC(=S)S/C1=C\c1csc(-c2cccc(N3CCCCC3)c2)n1 CHEMBL4060062 IC50 7.0 nM
O=c1[nH]c(-c2ccc(NCC3CCNCC3)cc2Cl)nc2c1oc1ccc(Br)cc12 CHEMBL4070120 IC50 7.0 nM
COc1cccc(-c2c[nH]c3ccc(-c4cncc(NCCN(C)C)n4)cc23)c1 CHEMBL4128290 IC50 7.0 nM
CN(C)CCNc1cncc(-c2ccc3[nH]cc(-c4ccccc4F)c3c2)n1 CHEMBL4126848 IC50 7.0 nM
NC1CCCN(c2cncc(-c3ccc4[nH]cc(-c5ccccc5F)c4c3)n2)C1 CHEMBL4129929 IC50 7.0 nM
CN1CCC(Nc2cccc3ccc(-c4nnc5c6c(cnn45)N(C)CCO6)nc23)CC1 CHEMBL4468395 IC50 7.0 nM
COCCN1CCOc2c1cnn1c(-c3ccc4cccc(NCC5CCNCC5)c4n3)nnc21 CHEMBL4556293 IC50 7.0 nM
CN1CCOc2c1cnn1c(-c3ccc4ccnc(NCC5(F)CCNCC5)c4c3)nnc21 CHEMBL4460019 IC50 7.0 nM
Cn1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)n1 CHEMBL3951436 Ki 7.16 nM
NCCNc1ccn2ncc(-c3ccc4[nH]c(=O)[nH]c4c3)c2n1 CHEMBL2442304 IC50 7.2 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cccc3CO)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1 CHEMBL4108206 Ki 7.2 nM
Cc1cccc(Nc2ccc3cccc(-c4cc5c([nH]4)CCNC5=O)c3n2)c1 CHEMBL3891519 IC50 7.2 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(C)COC1 CHEMBL3897814 IC50 7.2 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CC[C@@H](O)C3)n2)cn1 CHEMBL4106807 Ki 7.22 nM
Fc1cc(OCC2(F)CNC2)c2nc(-c3nnc4ccccn34)ccc2c1 CHEMBL3664611 IC50 7.3 nM
C[C@@H]1CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)[C@@H](C)CN1 CHEMBL4108465 IC50 7.3 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(CC(C)(C)C)nc34)[nH]c21 CHEMBL4559238 IC50 7.3 nM
N[C@@H]1CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)CC[C@H]1F CHEMBL3973432 IC50 7.4 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(OC5CCCC5)nc34)cc21 CHEMBL3966407 IC50 7.4 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)C CHEMBL3890648 IC50 7.5 nM
c1cc(C2CC2)nc(-c2c[nH]c3ccc(-c4nnc(C5CC5)o4)cc23)n1 CHEMBL3947565 IC50 7.578 nM
N[C@@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C1 CHEMBL3911258 IC50 7.6 nM
C[C@H]1CCN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C[C@@H]1N CHEMBL3931390 IC50 7.6 nM
Cc1cccc(C)c1Nc1ccc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3942200 IC50 7.6 nM
CC(c1ccccc1)c1ccc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3898587 IC50 7.6 nM
C=C(C)CNc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1C CHEMBL3949181 IC50 7.6 nM
Cc1nc2cccc(-c3cc4c(=O)[nH]nc(C)c4[nH]3)c2nc1NC(C)(C)C CHEMBL3906911 IC50 7.63 nM
CN1CCC(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC1 CHEMBL3652642 Ki 7.65 nM
c1cc(C2CC2)nc(-c2c[nH]c3ccc(-c4nnc(NC5COC5)o4)cc23)n1 CHEMBL3952561 IC50 7.693 nM
Cn1cc(-c2cc3c(-c4ccccn4)n[nH]c3cn2)cn1 CHEMBL3634766 Ki 7.7 nM
C[C@@H]1C[C@H](N)CN(c2ccncc2Nc2ncc3ccc(-c4ccccc4F)nn23)C1 CHEMBL4113731 IC50 7.7 nM
O=C1NC(=O)/C(=C/c2ccnc(N3CCC(CNCc4ccc5ccccc5n4)CC3)n2)S1 CHEMBL4451418 Ki 7.7 nM
Cn1c(NC(C)(C)C)nc2c(-c3cc4n(c3)CCNC4=O)cccc2c1=O CHEMBL3962885 IC50 7.74 nM
CNc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1C CHEMBL3972842 IC50 7.8 nM
Cn1cc(-c2cc3c(-c4ccccc4F)n[nH]c3cn2)cn1 CHEMBL3959473 Ki 7.85 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL1970903 pKi 7.943 nM
Cn1cc(C2=C(c3cn(CCCSC(=N)N)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL6291 Kd 8.0 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccc(Cl)c(F)c4)cc32)c(=O)[nH]1 CHEMBL575675 Ki 8.0 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccc[nH]4)cc32)c(=O)[nH]1 CHEMBL572783 Ki 8.0 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccoc4)cc32)c(=O)[nH]1 CHEMBL572784 Ki 8.0 nM
COc1cccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3cnccc23)c1Cl CHEMBL1915633 IC50 8.0 nM
CCNC(=O)c1cccc2c1nc(Nc1ccccc1Cl)c1ccncc12 CHEMBL1915646 IC50 8.0 nM
Fc1ccc(Cl)cc1Nc1nc2c(-c3nnc[nH]3)cccc2c2cnccc12 CHEMBL1915639 IC50 8.0 nM
O=Cc1cn2c3c1ccc1c4ccccc4n(c13)CCCC2 CHEMBL1950228 IC50 8.0 nM
Clc1ccccc1Nc1nc2c(-c3nnc[nH]3)cccc2c2scnc12 CHEMBL2017329 IC50 8.0 nM
Fc1ccccc1Nc1nc2c(-c3nnc[nH]3)cccc2n2cccc12 CHEMBL2017332 IC50 8.0 nM
O=c1[nH]c(-c2cccc(Cl)c2Cl)nc2c1oc1ccc(Br)cc12 CHEMBL2035623 IC50 8.0 nM
CC(C)COc1cccc(/C=C2\SC(=O)NC2=O)c1N1CCC[C@@H](N)C1 CHEMBL2048870 IC50 8.0 nM
CN(C)CCN(C)c1cncc(-c2ccc3[nH]cc(-c4ccnc(N)n4)c3c2)n1 CHEMBL3264261 IC50 8.0 nM
Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(OC4CCNCC4)n3)c2c1 CHEMBL3393701 IC50 8.0 nM
CC(C)Oc1cncc(-c2c[nH]c3ccc(-c4nnc(N)s4)cc23)n1 CHEMBL3394171 IC50 8.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(C3CCCCC3)n2)C[C@@H](N)[C@@H]1O CHEMBL3651985 IC50 8.0 nM
Nc1ccc(-c2ccccc2F)nc1C(=O)Nc1cnccc1-c1ccncc1 CHEMBL3793440 Ki 8.0 nM
FC1CNCCC1Oc1cccc2ccc(-c3nnc4ccc(Br)cn34)nc12 CHEMBL3660074 IC50 8.0 nM
Fc1cc(OC2CCNCC2F)c2nc(-c3nnc4ccccn34)ccc2c1 CHEMBL3660084 IC50 8.0 nM
CN(C)C1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(-c4ccc(F)c(F)c4)cn32)C2CCCCC2)CC1 CHEMBL3916318 IC50 8.0 nM
NCCC1CNC(=O)c2cc(-c3cccc(OC(F)(F)F)c3)c(-c3cccc(N)c3)n21 CHEMBL3891696 IC50 8.0 nM
COc1c(C)cc(-c2c(-c3cccc(OC(F)(F)F)c3)cc3n2[C@@H](CCN)CNC3=O)cc1C CHEMBL3959008 IC50 8.0 nM
Cc1cccc(-c2c(-c3cccc(OC(F)(F)F)c3)cc3n2[C@@H](CCNC(=N)N)CNC3=O)c1 CHEMBL3941232 IC50 8.0 nM
CS(=O)(=O)c1ccc(-c2c(-c3cccc(OC(F)(F)F)c3)cc3n2[C@@H](CCNC(=N)N)CNC3=O)cc1 CHEMBL3970786 IC50 8.0 nM
N[C@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4cccnc4Cl)nn23)C1 CHEMBL3915354 IC50 8.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NCC(C)(C)O CHEMBL3925309 IC50 8.0 nM
CO[C@H]1CC[C@H](Nc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1 CHEMBL3936197 IC50 8.0 nM
NC1CCCC(Nc2ccc3ncc(-c4cccc(Cl)c4)n3n2)C1 CHEMBL3976594 IC50 8.0 nM
O=C1NC(=S)S/C1=C\c1csc(-c2ccccc2O)n1 CHEMBL4069566 IC50 8.0 nM
COC/C=C/c1c(Cl)c2c(Cl)cc(C(N)=O)nc2n1C1CCCNC1 CHEMBL4096630 IC50 8.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCC(O)CC3)c2n1 CHEMBL4065094 IC50 8.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCCC(O)C3)c2n1 CHEMBL4086532 IC50 8.0 nM
CN(C)CCNc1cncc(-c2ccc3[nH]cc(-c4ccc(N)cc4)c3c2)n1 CHEMBL4130104 IC50 8.0 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Oc5ccccc5Cl)nc34)cc21 CHEMBL3937510 IC50 8.1 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(-c5c(F)cccc5F)nc34)cc21 CHEMBL3966499 IC50 8.1 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1CCCNC1 CHEMBL3899021 IC50 8.1 nM
CN(C)c1cncc(-c2c[nH]c3ccc(-c4nnc(N)s4)cc23)n1 CHEMBL3922231 IC50 8.178 nM
COCCOc1ccc2nnc(-c3ccc4cccc(OCC5(F)CCNCC5)c4n3)n2c1 CHEMBL3664614 IC50 8.3 nM
O=C1NCCc2[nH]c(-c3cccc4cnc(Nc5ccccc5)nc34)cc21 CHEMBL3936246 IC50 8.3 nM
c1cc(-c2n[nH]c3cnc(C4CCOC4)cc23)nc(N2CCNCC2)c1 CHEMBL3940311 Ki 8.48 nM
c1cc(-c2n[nH]c3cnc(C4CCCO4)cc23)nc(N2CCNCC2)c1 CHEMBL3634762 Ki 8.5 nM
COC(=O)N(C)[C@@H]1[C@H](C)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C)cc3F)n2)C[C@@H]1N CHEMBL3687462 IC50 8.5 nM
Cc1cc(N)cc(-c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)c1 CHEMBL3949500 IC50 8.6 nM
Fc1ccccc1-c1n[nH]c2cnc(-c3cn[nH]c3)cc12 CHEMBL3922340 Ki 8.69 nM
FCCN1CCC(F)(COc2cccc3ccc(-c4nnc5ccccn45)nc23)CC1 CHEMBL3660095 IC50 8.7 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CC(F)(F)C1 CHEMBL3903663 IC50 8.7 nM
COc1nc(-c2cn(S(=O)(=O)c3ccc(C)cc3)c3ccc(-c4nnc(NC(C)(C)C)o4)cc23)ncc1F CHEMBL3964497 IC50 8.767 nM
Cc1ccnc(-c2c[nH]c3ccc(-c4nnc(NC(C)(C)C)o4)cc23)n1 CHEMBL3968456 IC50 8.767 nM
c1cncc(-c2cc3c(-c4ccncc4)n[nH]c3cn2)c1 CHEMBL3910899 Ki 8.77 nM
CC(C)Oc1cccc(-c2c[nH]c3ccc(-c4nnc(N5CC[C@@H](N)C5)s4)cc23)n1 CHEMBL3900578 IC50 8.84 nM
NCCCCNc1nc2c(Br)c(Br)c(Br)c(Br)c2[nH]1 CHEMBL2159218 IC50 8.85 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CCCCCC1 CHEMBL3981339 IC50 8.9 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(N5CCOCC5)n4)c3c2)o1 CHEMBL3964669 IC50 8.914 nM
O=c1[nH]c(CN2CC[C@@H](O)C2)nc2c1sc1ccc(Cl)cc12 CHEMBL574819 Ki 9.0 nM
C=Cc1ccc2sc3c(=O)[nH]c(CN(C)C)nc3c2c1 CHEMBL573470 Ki 9.0 nM
Oc1ccc(-c2ccc3c(-c4ccc(N5CCNCC5)cc4)n[nH]c3n2)cc1 CHEMBL1910893 IC50 9.0 nM
CNC(=O)c1cccc2c1nc(Nc1ccccc1Cl)c1ccncc12 CHEMBL1915644 IC50 9.0 nM
FC(F)(F)c1cccc(-n2nnc3ccc(NCC4CC5(CCNCC5)C4)nc32)c1 CHEMBL1952136 IC50 9.0 nM
Fc1ccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3sccc23)c(Cl)c1 CHEMBL2017342 IC50 9.0 nM
Fc1ccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3sccc23)cc1F CHEMBL2017349 IC50 9.0 nM
Fc1cc(F)cc(Nc2nc3c(-c4nnc[nH]4)cccc3c3sccc23)c1 CHEMBL2017344 IC50 9.0 nM
O=c1[nH]c(CN2CCC2)nc2c1oc1ccc(Br)cc12 CHEMBL2035632 IC50 9.0 nM
N[C@@H]1CCCN(c2ccccc2/C=C2\SC(=O)NC2=O)C1 CHEMBL2048865 IC50 9.0 nM
CN1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(-c4cccc(F)c4)cn32)C2CCCCC2)CC1 CHEMBL3297761 IC50 9.0 nM
O=Cc1cn2c3c1ccc1c4ccccc4n(c13)CCCCC2 CHEMBL3627997 IC50 9.0 nM
OC[C@@H]1CC(Oc2cccc3ccc(-c4nnc5ccccn45)nc23)CCN1 CHEMBL3660053 IC50 9.0 nM
C[C@@H]1CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1O CHEMBL3676291 IC50 9.0 nM
NCC[C@H]1CNC(=O)c2cc(-c3cccc(OC(F)(F)F)c3)c(-c3ccccc3)n21 CHEMBL3981107 IC50 9.0 nM
Nc1cccc(-c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)c1 CHEMBL3973689 IC50 9.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCN/C4=N/O)c2nc1NC(C)(C)C CHEMBL3934276 IC50 9.0 nM
CC(C)(O)[C@H]1CC[C@H](Nc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1 CHEMBL3917577 IC50 9.0 nM
COc1ccc(-c2c[nH]c3ccc(-c4cncc(NCCN(C)C)n4)cc23)cc1 CHEMBL4129779 IC50 9.0 nM
CN(C)CCNc1cncc(-c2ccc3[nH]cc(-c4ccc(S(N)(=O)=O)cc4)c3c2)n1 CHEMBL4127644 IC50 9.0 nM
CN(C)CCNc1cncc(-c2ccc3[nH]cc(-c4cc(C#N)ccc4F)c3c2)n1 CHEMBL4128288 IC50 9.0 nM
CN(C)CCNc1cncc(-c2ccc3[nH]cc(-c4cccc(F)c4F)c3c2)n1 CHEMBL4128205 IC50 9.0 nM
CN1CCC(CNC2=NC(=O)/C(=C/c3csc(-c4ccc(OC(F)(F)F)cc4)n3)S2)CC1 CHEMBL4757567 IC50 9.0 nM
c1cc2[nH]cc(-c3cncc(C4CC4)n3)c2cc1-c1nnc(N2CCCC2)o1 CHEMBL3914961 IC50 9.142 nM
O=C1NC(=S)S/C1=C\c1csc(-c2ccccc2C(F)(F)F)n1 CHEMBL4077499 IC50 9.2 nM
CC(C)Oc1cccc(-c2c[nH]c3ccc(-c4nnc(N[C@@H]5CCCNC5)s4)cc23)n1 CHEMBL3985841 IC50 9.228 nM
COC1=NCCc2[nH]c(-c3cccc4nc(C)c(NC(C)(C)C)nc34)cc21 CHEMBL3916951 IC50 9.23 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(-c5ccccc5)n4)c3c2)o1 CHEMBL3967996 IC50 9.232 nM
Cc1cc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1Oc1ccccc1 CHEMBL3913032 IC50 9.3 nM
CCCn1c(N2CCNCC2)nc2c(Br)c(Br)c(Br)c(Br)c21 CHEMBL3639838 IC50 9.36 nM
NCCNc1ccn2ncc(-c3ccc4cn[nH]c4c3)c2n1 CHEMBL2442305 IC50 9.4 nM
FC1(COc2cccc3ccc(-c4nnc5ccccn45)nc23)CNC1 CHEMBL3660097 IC50 9.4 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(-c5cccc(Cl)c5)n4)c3c2)o1 CHEMBL3952591 IC50 9.406 nM
Nc1nnc(-c2ccc3[nH]cc(-c4nccc(Nc5ccccc5)n4)c3c2)o1 CHEMBL3899404 IC50 9.409 nM
Cc1nc2cccc(-c3cc4c(n3C)CCNC4=O)c2nc1NC(C)(C)C CHEMBL3984361 IC50 9.48 nM
Cc1nc2cccc(-c3cc4n(c3)C(CCO)CNC4=O)c2nc1NC(C)(C)C CHEMBL3949953 IC50 9.5 nM
c1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)cc1 CHEMBL3634790 Ki 9.65 nM
CC[C@@H]1COCCN1c1nnc(-c2ccc3[nH]cc(-c4cncc(C5CC5)n4)c3c2)o1 CHEMBL4115309 IC50 9.659 nM
CC(C)Oc1ncccc1-c1nc(C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@H](F)CO2)cs1 CHEMBL4109435 Ki 9.7 nM
O=C1N(CC2CCNCC2)CCN1c1n[nH]c2cnc(-c3cccnc3)cc12 CHEMBL3962063 Ki 9.74 nM
FC1CNCCC1Oc1cccc2ccc(-c3nnc4ccccn34)nc12 CHEMBL3660088 IC50 9.8 nM
c1cc2[nH]cc(-c3cncc(C4CC4)n3)c2cc1-c1nnc(C2CC2)o1 CHEMBL3970104 IC50 9.921 nM
COCCOCC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1C CHEMBL3971171 IC50 9.94 nM