C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3105022 Ki 0.002 nM
C[C@H]1CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@@H]1O CHEMBL3105021 Ki 0.002 nM
Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 CHEMBL3103868 Ki 0.004 nM
Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1N1CC[C@@H](O)[C@H](N)C1 CHEMBL3103869 Ki 0.006 nM
C[C@H]1NC(=O)c2cc(-c3c(F)ccc4c(=O)n(C)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3902148 IC50 0.012 nM
CC(C)n1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccc2c1=O CHEMBL3940091 IC50 0.012 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C1 CHEMBL3651966 Ki 0.018 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccccc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C1 CHEMBL4741714 IC50 0.018 nM
Cn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](CCN)NC4=O)cccc2c1=O CHEMBL3909351 IC50 0.02 nM
O=C(Nc1c[nH]c2ncc(-c3ccccc3F)cc12)c1cnn2ccc(NC[C@H]3CCNC[C@@H]3F)nc12 CHEMBL2387464 Ki 0.032 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)C3(CC3)NC4=O)c2nc1NC1(C)CC1 CHEMBL3949102 IC50 0.0354 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1N[C@H]1CCC[C@@H](N)C1 CHEMBL3903686 IC50 0.0358 nM
O=C(Nc1c[nH]c2ncc(-c3c(F)cccc3F)cc12)c1cnn2ccc(NC[C@H]3CCNC[C@@H]3F)nc12 CHEMBL2387465 Ki 0.037 nM
CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2[nH]c1=O CHEMBL3918907 IC50 0.0378 nM
CCn1c(NC2(C)CC2)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)c(F)ccc2c1=O CHEMBL3895124 IC50 0.0378 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@@H](N)CC(F)(F)C1 CHEMBL3623150 Ki 0.04 nM
CO[C@H]1C[C@H](N)CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)C1 CHEMBL4459538 Ki 0.04 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1NC1(C)CC1 CHEMBL3949318 IC50 0.0484 nM
Cc1cncc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)n1 CHEMBL3634783 Ki 0.049 nM
Cc1nc2cccc3c2nc1NCCCC[C@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3808669 IC50 0.05 nM
Cc1nc2cccc3c2nc1N[C@H](C)/C=C/C[C@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3808887 IC50 0.05 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 CHEMBL3676285 Ki 0.05 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(N)CC(F)C1 CHEMBL4439756 Ki 0.05 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5(C)CC5)c(NC5(C)CC5)nc34)[nH]c21 CHEMBL4568404 IC50 0.05 nM
C[C@H]1NC(=O)c2cc(-c3c(F)ccc4c3N=C(NC3(C)CC3)N(C3CC3)C4)[nH]c21 CHEMBL3949175 IC50 0.06 nM
Cc1nc2ccc(F)c(-c3cc4c(=O)[nH]ccc4[nH]3)c2nc1NC(C)(C)C CHEMBL3896195 IC50 0.0667 nM
Cc1nc2cccc3c2nc1NC/C=C\C[C@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3810121 IC50 0.07 nM
CCn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)c(F)ccc2c1=O CHEMBL3960373 IC50 0.0741 nM
O=C(Nc1c[nH]c2ncc(-c3c(F)cccc3F)cc12)c1cnn2ccc(NCC3CCNCC3)nc12 CHEMBL2387471 Ki 0.076 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5CC5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3919725 IC50 0.076 nM
CCn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccc2c1=O CHEMBL3909217 IC50 0.077 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C3CC3)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3932475 Ki 0.077 nM
Cc1nc2cccc(-c3[nH]c4c(c3Cl)C(=O)NC4)c2nc1NC1(C)CC1 CHEMBL3933056 IC50 0.0783 nM
C/C1=C\C[C@H]2CNC(=O)c3cc([nH]c32)-c2cccc3nc(C)c(nc23)NC1 CHEMBL3808662 IC50 0.08 nM
C[C@H]1CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C[C@@H](N)[C@@H]1O CHEMBL3966732 IC50 0.08 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CC5CC5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4441708 IC50 0.08 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cnn(C)c4)cc23)nc1N1CCC[C@H](N)C1 CHEMBL3634760 Ki 0.088 nM
N[C@@H]1CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C[C@H](N)[C@H]1O CHEMBL3950251 IC50 0.09 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5CC5)c(NC5(C)CC5)nc34)[nH]c21 CHEMBL3958862 IC50 0.09 nM
O=C(Nc1c[nH]c2ncc(-c3ccccc3F)cc12)c1cnn2ccc(NCC3CCNCC3)nc12 CHEMBL2387463 Ki 0.094 nM
C[C@@H]1C[C@H](N)CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C1 CHEMBL3942186 IC50 0.094 nM
C[C@H]1C[C@@H](N)CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C1 CHEMBL3965946 IC50 0.1 nM
C[C@H]1C[C@@H](N)CN(c2ccncc2Nc2ncc3ccc(-c4ccccc4F)nn23)C1 CHEMBL3930148 IC50 0.1 nM
C[C@@H]1C[C@H](N)CN(c2ccncc2Nc2ncc3ccc(-c4cc(C(=O)NC5CC5)ccc4F)nn23)C1 CHEMBL4110951 IC50 0.1 nM
CCN(c1cnc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1)C(C)(C)C CHEMBL3901766 IC50 0.1 nM
C[C@H]1NC(=O)c2cc(-c3c(F)ccc4c(=O)n(C5CC5)c(NC5(C)CCC5)nc34)[nH]c21 CHEMBL3944421 IC50 0.1 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(N[C@H]5CCC[C@@H](N)C5)nc34)[nH]c21 CHEMBL3918273 IC50 0.1 nM
C[C@H]1NC(=O)c2cc(-c3c(F)ccc4c(=O)n(C)c(NC5(C)CC5)nc34)[nH]c21 CHEMBL3941050 IC50 0.1 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC[C@H](N)CC1 CHEMBL4437940 Ki 0.1 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@@H](N)[C@H](F)CC1 CHEMBL3648680 Ki 0.1 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1NC(C)(C)C CHEMBL3979182 IC50 0.1 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CC(N)CCC3C)n2)n1 CHEMBL3976267 Ki 0.109 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CCCO)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3919616 IC50 0.11 nM
Cc1cncc(-c2cc3c(-c4cccc(N5CCCNCC5)n4)n[nH]c3cn2)n1 CHEMBL3978766 Ki 0.11 nM
COc1ccc(-n2ncc3cnc(-c4cncc(C)n4)cc32)nc1N1CCC[C@H](N)C1 CHEMBL3914639 Ki 0.11 nM
CC(c1cn(C)cn1)n1c(NC2(C)CC2)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccc2c1=O CHEMBL4471849 IC50 0.11 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C(F)(F)F)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3961823 Ki 0.115 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CC5CC5)c(NC5(C)CC5)nc34)[nH]c21 CHEMBL4436404 IC50 0.12 nM
N#CCn1cc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3634771 Ki 0.127 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(NC5(C)CCC5)nc34)[nH]c21 CHEMBL3968854 IC50 0.13 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C[C@H]5CCCO5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4461181 IC50 0.13 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(C)CCC1 CHEMBL3957722 IC50 0.136 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3982539 Ki 0.142 nM
CCn1cncc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)c1=O CHEMBL3634769 Ki 0.145 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n([C@@H](C)c5cn(C)cn5)c(NC5(C)CC5)nc34)[nH]c21 CHEMBL4450494 IC50 0.15 nM
N[C@@H]1CCCN(c2c(/C=C3\SC(=O)NC3=O)cccc2-c2ccccc2)C1 CHEMBL2048872 Ki 0.16 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1N[C@H]1CCC[C@@H](NC(=O)[C@H](N)CO)C1 CHEMBL3910446 IC50 0.16 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5(C)CC5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4456165 IC50 0.16 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(Cc5cn(C)cn5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4563904 IC50 0.16 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CC5(N)CC5)c(NC5(C)CC5)nc34)[nH]c21 CHEMBL4513589 IC50 0.16 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(C)CC1 CHEMBL3890727 IC50 0.162 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC[C@@H](N)CC1 CHEMBL3652638 Ki 0.167 nM
Cn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2c1=O CHEMBL3890346 IC50 0.169 nM
O=C(Nc1c[nH]c2ncc(-c3c(F)cccc3F)cc12)c1cnn2ccc(CCC3CCNCC3)nc12 CHEMBL2387474 Ki 0.17 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3634767 Ki 0.17 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](CO)NC4=O)c2nc1NC1CC1 CHEMBL3942145 IC50 0.177 nM
C[C@@H]1CCN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C[C@H]1N CHEMBL3896244 IC50 0.18 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5CCC5)c(NC5(C)CC5)nc34)[nH]c21 CHEMBL4470271 IC50 0.18 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CC5(O)CC5)c(NC5(C)CC5)nc34)[nH]c21 CHEMBL4446411 IC50 0.18 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1NC1(C)CC1 CHEMBL3903402 IC50 0.183 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C3CC3)c(N3CCC[C@H](N)C3)n2)c1 CHEMBL3930816 Ki 0.187 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CC(F)(F)F)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3924828 IC50 0.19 nM
Cn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)CNC4=O)cccc2c1=O CHEMBL3897988 IC50 0.193 nM
COCCn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccc2c1=O CHEMBL3947143 IC50 0.193 nM
CCc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)C CHEMBL3914535 IC50 0.195 nM
Cc1nc2cccc3c2nc1NCCCC[C@@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3808942 IC50 0.2 nM
C/C1=C/C[C@H]2CNC(=O)c3cc([nH]c32)-c2cccc3nc(C)c(nc23)NC1 CHEMBL3809940 IC50 0.2 nM
Cc1nc2cccc3c2nc1N[C@H](C)CCC[C@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3810095 IC50 0.2 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@@H]1CCC[C@H](N)C1 CHEMBL3958307 IC50 0.2 nM
CC(C)Nc1nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)c(F)ccc2c(=O)n1C1CC1 CHEMBL3984961 IC50 0.2 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5CC5)c(NC5(C)CCC5)nc34)[nH]c21 CHEMBL3911461 IC50 0.2 nM
C[C@H]1NC(=O)c2cc(-c3c(F)ccc4c(=O)n(C)c(NC5(C)CCC5)nc34)[nH]c21 CHEMBL3896782 IC50 0.2 nM
N[C@H]1CCCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 CHEMBL3956349 Ki 0.2 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCC[C@H](N)C5)n4)n[nH]c3cn2)cn1 CHEMBL3634758 Ki 0.2 nM
Nc1ccc(-c2ccccc2F)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 CHEMBL3103867 Ki 0.2 nM
CO[C@@H]1CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC[C@H]1N CHEMBL3648724 Ki 0.2 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@@H](N)[C@@H](O)CC1 CHEMBL4453890 Ki 0.2 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3979678 IC50 0.2 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)[C@H](C)NC4=O)c2nc1NC(C)(C)C CHEMBL3940707 IC50 0.201 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@H](C)NC4=O)c2nc1NC1(C)CC1 CHEMBL3979954 IC50 0.201 nM
Cc1nc2cccc(-c3cc4c([nH]3)C(CO)NC4=O)c2nc1NC1CC1 CHEMBL3905144 IC50 0.212 nM
COCCn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)CNC4=O)cccc2c1=O CHEMBL3919362 IC50 0.218 nM
Cc1nc2cccc(-c3cc4c([nH]3)C3(CC3)NC4=O)c2nc1NC(C)(C)C CHEMBL3896124 IC50 0.223 nM
OCC#Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3934383 Ki 0.228 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc([C@H]3CNCCC3(F)F)n2)n1 CHEMBL4076913 Ki 0.23 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CC5(O)CC5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4591512 IC50 0.23 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C(F)F)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3940744 Ki 0.233 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(C3CNCCC3(F)F)n2)n1 CHEMBL3926007 Ki 0.234 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)[nH]c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3934565 IC50 0.24 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CC5(N)CC5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4468122 IC50 0.24 nM
Cc1nc2cccc(-c3cc4c([nH]3)C3(CC3)NC4=O)c2nc1NC1CC1 CHEMBL3924143 IC50 0.242 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1NCC(F)F CHEMBL3937161 IC50 0.246 nM
c1cc(-c2n[nH]c3cnc(-c4cnn(CC5CC5)c4)cc23)nc(N2CCNCC2)c1 CHEMBL3634772 Ki 0.253 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cnc(C3CC3)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3920778 Ki 0.257 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1N[C@H]1CCC[C@@H](NCC(F)(F)F)C1 CHEMBL3913446 IC50 0.267 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)CO CHEMBL3927716 IC50 0.272 nM
CCC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)c(F)ccc2nc1C CHEMBL3897606 IC50 0.275 nM
Cc1nc2nccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)C CHEMBL3919994 IC50 0.278 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C#N)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3898989 Ki 0.286 nM
C[C@@H]1[C@@H](N)CCCN1c1ccncc1Nc1ncc2ccc(-c3c(F)cccc3F)nn12 CHEMBL3905194 IC50 0.29 nM
Cc1nc2cccc(-c3cc4c([nH]3)CNC4=O)c2nc1NC1CC1 CHEMBL3903837 IC50 0.297 nM
Cc1cncc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)c1 CHEMBL3634782 Ki 0.3 nM
Cc1nc2cccc3c2nc1N[C@@H](C)/C=C/C[C@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3809986 IC50 0.3 nM
Cc1nc2cccc3c2nc1NC[C@@H](C)CC[C@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3809565 IC50 0.3 nM
C[C@@H]1CC[C@H](N)CN1c1ccncc1Nc1ncc2ccc(-c3c(F)cccc3F)nn12 CHEMBL3965757 IC50 0.3 nM
N[C@H]1CCC[C@@H](Nc2ccc3cccc(-c4cc5c([nH]4)CCNC5=O)c3n2)C1 CHEMBL3907732 IC50 0.3 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(C)CC1 CHEMBL3957954 IC50 0.3 nM
CC(C)(C)Nc1cnc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3926782 IC50 0.3 nM
CC1(Nc2cnc3cccc(-c4cc5c([nH]4)CCNC5=O)c3n2)CC1 CHEMBL3965643 IC50 0.3 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CCCS(C)(=O)=O)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3932047 IC50 0.3 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@@H](N)C(F)(F)CC1 CHEMBL4450356 Ki 0.3 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1CCC(N)C(F)CC1 CHEMBL4469964 Ki 0.3 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)C CHEMBL4587596 IC50 0.3 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](CCN)NC4=O)c2nc1NC(C)(C)C CHEMBL4541192 IC50 0.3 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1C[C@@H](N)C1 CHEMBL3966363 IC50 0.301 nM
CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1N CHEMBL3943301 IC50 0.305 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(F)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3953164 Ki 0.314 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCCC(N)CC1 CHEMBL3652626 Ki 0.316 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(Cl)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3891851 Ki 0.317 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)n1 CHEMBL3943705 Ki 0.333 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(C(F)(F)F)CC1 CHEMBL3961328 IC50 0.338 nM
OCCNc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3946464 Ki 0.357 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(NC5(C)CC5)nc34)[nH]c21 CHEMBL3950704 IC50 0.364 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](N)C3)n2)n1 CHEMBL3896312 Ki 0.37 nM
O[C@H]1CNCCN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)C1 CHEMBL3909280 Ki 0.373 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)[C@H](C)NC4=O)c2nc1NC1(C)CC1 CHEMBL3943763 IC50 0.385 nM
Cc1nc2cccc(-c3cc4c([nH]3)C3(CC3)NC4=O)c2nc1NC1(C)CC1 CHEMBL3909785 IC50 0.39 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(CO)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3892885 Ki 0.394 nM
Nc1ccc(-c2ccc3[nH]nc(-c4cncc(O[C@H]5CNCCC56CC6)n4)c3c2)c(F)c1 CHEMBL3393716 IC50 0.4 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@H]1OCCC#N CHEMBL3691950 IC50 0.4 nM
Cc1nc2cccc3c2nc1N[C@@H](C)CCC[C@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3809127 IC50 0.4 nM
Cc1nc2cccc3c2nc1NC[C@H](C)CC[C@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3809377 IC50 0.4 nM
C[C@@H]1C[C@H](N)CN(c2ccncc2Nc2ncc3ccc(-c4nccs4)nn23)C1 CHEMBL4109688 IC50 0.4 nM
C[C@@H]1C[C@H](N)CN(c2ccncc2Nc2ncc3ccc(-c4ncccc4F)nn23)C1 CHEMBL3913540 IC50 0.4 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@@H]1CC[C@H](N)C1 CHEMBL3966072 IC50 0.4 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(CO)CC1 CHEMBL3891210 IC50 0.4 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)[nH]c(N(C)C(C)(C)C)nc34)[nH]c21 CHEMBL3962064 IC50 0.4 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1C[C@H](N)C1 CHEMBL3928595 IC50 0.4 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCCC(N)C(F)C1 CHEMBL3648675 Ki 0.4 nM
Cn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)C3(CC3)NC4=O)cccc2c1=O CHEMBL3946152 IC50 0.407 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C[C@@H]5CN(C)CCO5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4476513 IC50 0.41 nM
Cn1cc(-c2cc3c(-c4cccc(N5CC[C@@H](N)C5)n4)n[nH]c3cn2)cn1 CHEMBL3634757 Ki 0.43 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)n1 CHEMBL3960554 Ki 0.44 nM
OCCCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3910536 Ki 0.446 nM
Cc1nc2cccc(-c3[nH]c4c(c3Cl)C(=O)NCC4)c2nc1NC(C)(C)C CHEMBL3971342 IC50 0.454 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@H]1OCCS(C)(=O)=O CHEMBL3691930 IC50 0.47 nM
Cc1nc2cccc(-c3cc4c([nH]3)C(CCO)NC4=O)c2nc1NC(C)(C)C CHEMBL3955880 IC50 0.47 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3634761 Ki 0.473 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCC(N)C3C)n2)n1 CHEMBL3927952 Ki 0.477 nM
Cc1cncc(-c2cc3c(cnn3-c3cccc(N4CCCNCC4)n3)nn2)n1 CHEMBL4091687 Ki 0.48 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](N)C3)n2)n1 CHEMBL3935096 Ki 0.499 nM
c1cncc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)c1 CHEMBL3634781 Ki 0.5 nM
Cc1nc2cccc3c2nc1NC/C=C/C[C@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3809463 IC50 0.5 nM
Cc1nc2cccc3c2nc1N[C@H](C)/C=C\C[C@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3809691 IC50 0.5 nM
N[C@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C1 CHEMBL3919646 IC50 0.5 nM
FC1(COc2cccc3ccc(-c4nnc5ccccn45)nc23)CCNCC1 CHEMBL3664634 IC50 0.5 nM
C[C@H]1CN(c2ccncc2Nc2ncc3ccc(-c4ccc(S(C)(=O)=O)cc4F)nn23)C[C@@H](N)[C@@H]1O CHEMBL3986154 IC50 0.5 nM
C[C@@H]1CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C[C@@H](N)[C@H]1O CHEMBL4109503 IC50 0.5 nM
N[C@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4cc(C(=O)NC5CC5)ccc4F)nn23)C1 CHEMBL3918076 IC50 0.5 nM
C[C@@H]1C[C@H](N)CN(c2ccncc2Nc2ncc3ccc(-c4ncccc4Cl)nn23)C1 CHEMBL4115280 IC50 0.5 nM
Cc1nc2cccc(-c3cc4c([nH]3)C(C)CNC4=O)c2nc1F CHEMBL3947213 IC50 0.5 nM
Cn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](CCO)NC4=O)cccc2c1=O CHEMBL3933742 IC50 0.5 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)CNC4=O)c2nc1NC(C)(C)C CHEMBL3944136 IC50 0.501 nM
O=C(Nc1c[nH]c2ccc(-c3c(F)cccc3F)nc12)c1cnn2ccc(NCC3CCNCC3)nc12 CHEMBL2387473 Ki 0.52 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)C3(CC3)NC4=O)c2nc1NC(C)(C)C CHEMBL3974455 IC50 0.52 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](CO)NC4=O)c2nc1NC1(C)CC1 CHEMBL3920600 IC50 0.53 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNC(C)C3)n2)n1 CHEMBL3937096 Ki 0.54 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1NC(C)(C)C CHEMBL3974543 IC50 0.559 nM
FC1CCNCC1c1cccc(-n2ncc3cnc(-c4cnn(CC(F)(F)F)c4)cc32)n1 CHEMBL3900425 Ki 0.56 nM
Cc1nc2cccc(-c3cc4c([nH]3)CNC4=O)c2nc1NC1(C)CC1 CHEMBL3957073 IC50 0.57 nM
Cc1nc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](N)C3)n2)cnc1N CHEMBL3906798 Ki 0.575 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3634770 Ki 0.58 nM
Cc1nc2cccc(-c3[nH]c4c(c3Cl)C(=O)N[C@@H]4C)c2nc1NC1(C)CC1 CHEMBL3933719 IC50 0.599 nM
NC(=O)c1ccc(-c2ccc3[nH]nc(-c4cncc(O[C@H]5CNCCC56CC6)n4)c3c2)c(F)c1 CHEMBL3393718 IC50 0.6 nM
CS(=O)(=O)Nc1ccc(-c2ccc3[nH]nc(-c4cncc(O[C@H]5CNCCC56CC6)n4)c3c2)c(F)c1 CHEMBL3393720 IC50 0.6 nM
C[C@H]1CN(c2ccncc2Nc2ncc3ccc(-c4nccs4)nn23)C[C@@H](N)[C@@H]1O CHEMBL3936992 IC50 0.6 nM
CCN(c1cccnc1)c1ccc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3971351 IC50 0.6 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(C)CCCC1 CHEMBL3956884 IC50 0.6 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(C)CCC1 CHEMBL3904282 IC50 0.6 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NCC(C)(C)C CHEMBL3940808 IC50 0.6 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5CCC5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3904050 IC50 0.6 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CC5COC5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4472803 IC50 0.6 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)C CHEMBL3959725 IC50 0.6 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(N5CCCC5(C)C)nc34)[nH]c21 CHEMBL4572195 IC50 0.6 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H]1C CHEMBL3687492 IC50 0.62 nM
Cc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCC#N)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687493 IC50 0.63 nM
FC(F)(F)CNc1nnc(-c2ccc3[nH]cc(-c4nccc(C5CC5)n4)c3c2)o1 CHEMBL3940389 IC50 0.638 nM
O=C(Nc1c[nH]c2ncc(-c3c(F)cccc3F)cc12)c1cnn2ccc(OCC3CCNCC3)nc12 CHEMBL2387475 Ki 0.65 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H]1C CHEMBL3691958 IC50 0.65 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNC[C@H]3C)n2)n1 CHEMBL4112816 Ki 0.659 nM
Nc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)n1 CHEMBL3961692 Ki 0.664 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5CCOCC5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3926620 IC50 0.671 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(C3CCCC(N)C3)n2)n1 CHEMBL3929011 Ki 0.672 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3946970 Ki 0.678 nM
CS[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687443 IC50 0.68 nM
Oc1ccc(-c2ccc3[nH]nc(-c4cncc(O[C@H]5CNCCC56CC6)n4)c3c2)c(F)c1 CHEMBL3393717 IC50 0.7 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Nc5cccnc5)nc34)cc21 CHEMBL3937054 IC50 0.7 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NCC(C)C CHEMBL3970207 IC50 0.7 nM
CN(c1cnc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1)C(C)(C)C CHEMBL3985398 IC50 0.7 nM
CC[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C5CC5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3948310 IC50 0.7 nM
CC(c1cn(C)cn1)n1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccc2c1=O CHEMBL4464030 IC50 0.7 nM
Cc1cncc(-c2cc3c(cnn3-c3cccc(N4CCNCC4)n3)nn2)n1 CHEMBL3970953 Ki 0.71 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCC[C@@H](N)C5)n4)n[nH]c3cn2)cn1 CHEMBL3634756 Ki 0.72 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cnc(C)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3935018 Ki 0.724 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(F)CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1OCCC#N CHEMBL3691937 IC50 0.74 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1N=[N+]=[N-] CHEMBL3687497 IC50 0.74 nM
CC(C)NC(=O)c1ccc(F)c(-c2ccc(N)c(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCC#N)[C@@H](C)C3)n2)c1 CHEMBL3687521 IC50 0.74 nM
N[C@H]1CCC[C@@H]1Oc1cncc(-c2cc3c(cn2)cnn3-c2ccccn2)n1 CHEMBL3963170 Ki 0.744 nM
Cc1nc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cnc1N CHEMBL3959091 Ki 0.748 nM
C[C@H]1CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691940 IC50 0.77 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691960 IC50 0.77 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(OC3CCCC(N)C3)n2)n1 CHEMBL3924903 Ki 0.779 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H](N)[C@H]1OCCS(C)(=O)=O CHEMBL3691919 IC50 0.78 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC(C)C)cc3F)n2)C[C@@H]1C CHEMBL3691926 IC50 0.79 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC(C)C)cc3F)n2)C[C@@H]1C CHEMBL3691932 IC50 0.79 nM
C[C@H]1C[C@H](N)CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C1 CHEMBL3897323 IC50 0.79 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CCC1 CHEMBL3960320 IC50 0.8 nM
CC1(C)CCCN1c1cnc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3956736 IC50 0.8 nM
CC1(C)CCN1c1cnc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3985959 IC50 0.8 nM
CC[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3946176 IC50 0.8 nM
NCCOc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3960453 Ki 0.806 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)C[C@@H]1C CHEMBL3691942 IC50 0.81 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C)cc3F)n2)C[C@@H]1C CHEMBL3687490 IC50 0.82 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H]1C CHEMBL3687482 IC50 0.83 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C(C)(C)C)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4436502 IC50 0.83 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1N CHEMBL3687430 IC50 0.86 nM
C[C@@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3913164 IC50 0.864 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNC[C@@H]3C)n2)n1 CHEMBL3949274 Ki 0.864 nM
Cc1cc(F)c(-c2nc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691945 IC50 0.87 nM
Cc1nc2cccc(-c3[nH]c4c(c3Br)C(=O)NCC4)c2nc1NC(C)(C)C CHEMBL3964367 IC50 0.874 nM
Cc1nc2cccc(-c3cc4c([nH]3)CNC4=O)c2nc1NC(C)(C)C CHEMBL3940411 IC50 0.882 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687491 IC50 0.89 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3944062 Ki 0.893 nM
O=c1[nH]c(CN2CC[C@H](O)C2)nc2c1sc1ccc(/C=C/C3CC3)cc12 CHEMBL573463 Ki 0.9 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H]1C CHEMBL3691929 IC50 0.9 nM
CCC1CNC(=O)c2cc(-c3cccc4cc(C)c(Nc5ccccc5)nc34)[nH]c21 CHEMBL3889660 IC50 0.9 nM
O=C1NCCc2[nH]c(-c3c(F)ccc4ccc(Nc5cccnc5)nc34)cc21 CHEMBL3978196 IC50 0.9 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(NC(C)(C)CO)nc34)[nH]c21 CHEMBL4587256 IC50 0.9 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NCC1(C)CC1 CHEMBL3906357 IC50 0.902 nM
COCCOCCn1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccc2c1=O CHEMBL3918647 IC50 0.917 nM
Cc1nc2cccc(-c3cc4n(c3)CCNC4=O)c2nc1NC1(C)CC1 CHEMBL3978475 IC50 0.961 nM
c1cc(N2CCCNCC2)nc(-n2ncc3cnc(-c4cnn(C5CC5)c4)cc32)c1 CHEMBL3984183 Ki 0.978 nM
COc1ncc(-n2ncc3cnc(-c4cncc(C)n4)cc32)nc1N1CCC[C@H](N)C1 CHEMBL3897912 Ki 0.979 nM
Nc1nnc(-c2ccc3[nH]cc(-c4nccc(C5CC5)n4)c3c2)o1 CHEMBL3893588 IC50 0.984 nM
COc1cccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3cnccc23)c1Cl CHEMBL1915633 IC50 1.0 nM
Fc1cccc(F)c1Nc1nc2c(-c3nnc[nH]3)cccc2c2cnccc12 CHEMBL1915636 IC50 1.0 nM
CNC(=O)c1cccc2c1nc(Nc1ccccc1Cl)c1ccncc12 CHEMBL1915644 IC50 1.0 nM
Oc1ccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3cnccc23)c(Cl)c1 CHEMBL1915445 IC50 1.0 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 1.0 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1O[C@H]1CCNC1 CHEMBL3354518 IC50 1.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](O)[C@@H]1O CHEMBL3652015 IC50 1.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H](N)[C@H]1OCCC#N CHEMBL3687474 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)ccc(O)c3F)n2)C1 CHEMBL3652019 IC50 1.0 nM
Nc1cc(F)c(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@H]1C[C@@H](N)C[C@@H](C(F)(F)F)C1 CHEMBL3652004 IC50 1.0 nM
CSc1ncc2ccc3c(C(N)=O)cn([C@H]4CC[C@@H](N)CC4)c3c2n1 CHEMBL3703184 IC50 1.0 nM
Nc1cc(F)c(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@@H]1CCC[C@H](N)C1 CHEMBL3651994 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(O)cc3F)n2)C1 CHEMBL3652022 IC50 1.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](O)[C@@H]1O CHEMBL3652010 IC50 1.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(O)cc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3651899 IC50 1.0 nM
Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@H]1C[C@@H](N)C[C@@H](C(F)(F)F)C1 CHEMBL3652006 IC50 1.0 nM
Cc1nc2cccc3c2nc1NC/C=C/C[C@@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3809044 IC50 1.0 nM
Cc1nc2cccc3c2nc1NC/C=C\C[C@@H]1CNC(=O)c2cc-3[nH]c21 CHEMBL3808445 IC50 1.0 nM
C[C@H]1CC[C@H](N)CN1c1ccncc1Nc1ncc2ccc(-c3c(F)cccc3F)nn12 CHEMBL3900646 IC50 1.0 nM
C[C@@H]1CC[C@@H](N)CN1c1ccncc1Nc1ncc2ccc(-c3c(F)cccc3F)nn12 CHEMBL4112982 IC50 1.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)CCO CHEMBL3918196 IC50 1.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1C[C@@H](NCCF)C1 CHEMBL3902504 IC50 1.0 nM
Cc1nc2cccc(-c3[nH]c4c(c3Cl)C(=O)N[C@@H]4C)c2nc1NC(C)(C)C CHEMBL3932879 IC50 1.0 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(N(C)C(C)(C)C)nc34)[nH]c21 CHEMBL4589855 IC50 1.0 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(OC5(C)CC5)nc34)[nH]c21 CHEMBL3983621 IC50 1.01 nM
FC(F)(F)Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3972050 Ki 1.01 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC4CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3691921 IC50 1.03 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2ccc(Cl)c(N3CCC[C@H](N)C3)n2)c1 CHEMBL3908350 Ki 1.03 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691938 IC50 1.04 nM
c1cc2[nH]cc(-c3cncc(C4CC4)n3)c2cc1-c1nnc(NC2CNC2)o1 CHEMBL3905618 IC50 1.051 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCCC(N)C3)n2)n1 CHEMBL3937209 Ki 1.06 nM
C[C@H]1COCCN1c1ccnc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3937011 IC50 1.069 nM
COC(=O)N(C)[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687471 IC50 1.07 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3687509 IC50 1.08 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC4CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3691943 IC50 1.09 nM
Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(O[C@H]4CNCCC45CC5)n3)c2c1 CHEMBL3393706 IC50 1.1 nM
NC(=O)Nc1cc2c(-c3cccc(N4CCNCC4)n3)n[nH]c2cn1 CHEMBL3634775 Ki 1.1 nM
N[C@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4ncccc4F)nn23)C1 CHEMBL3914287 IC50 1.1 nM
N[C@H]1CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)CC[C@@H]1F CHEMBL3898611 IC50 1.1 nM
NC1CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)CCC1F CHEMBL3909297 IC50 1.1 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C[C@@H]5CCCO5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4556760 IC50 1.1 nM
CC(C)(C)Nc1ccc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3897826 IC50 1.11 nM
Cc1nc2cccc(-c3cc4c([nH]3)C3(CC3)NC4=O)c2nc1NCC(F)F CHEMBL3899535 IC50 1.12 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCC#N)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691949 IC50 1.13 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1OCCC#N CHEMBL3687495 IC50 1.13 nM
c1cc(N2CCNCC2)nc(-n2ncc3cnc(-c4cncc(C5CC5)n4)cc32)c1 CHEMBL3958785 Ki 1.14 nM
CC(C)Nc1nnc(-c2ccc3[nH]cc(-c4nc(C(=O)O)cc(C5CC5)n4)c3c2)o1 CHEMBL3970756 IC50 1.156 nM
c1cc(N2CCNCC2)nc(-n2ncc3cnc(-c4cnccn4)cc32)c1 CHEMBL3902417 Ki 1.16 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H]1C CHEMBL3687479 IC50 1.17 nM
CC(C)Oc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCS(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691925 IC50 1.17 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)C3(CC3)NC4=O)c2nc1NC(C)C CHEMBL3974046 IC50 1.17 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1cc(CO)nn1 CHEMBL3687476 IC50 1.18 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1cncn1 CHEMBL3687459 IC50 1.2 nM
CCOCc1cc(F)c(-c2nc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691941 IC50 1.2 nM
Cc1cc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1Nc1ccccc1 CHEMBL3928492 IC50 1.2 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@@H]1CCCNC1 CHEMBL3926862 IC50 1.2 nM
CC(C)NC(=O)c1ccc(F)c(-c2ccc(N)c(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCS(C)(=O)=O)[C@@H](C)C3)n2)c1 CHEMBL3687537 IC50 1.21 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)C[C@@H]1C CHEMBL3691922 IC50 1.22 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C3CC3)c(N3CCCNCC3)n2)n1 CHEMBL3922549 Ki 1.22 nM
Cc1nc2cccc(-c3cc4c(=O)[nH]cnc4[nH]3)c2nc1NC1CCC1 CHEMBL3986567 IC50 1.23 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)C[C@@H](N)[C@@H]1OCCS(C)(=O)=O CHEMBL3691923 IC50 1.24 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1OCCS(C)(=O)=O CHEMBL3687527 IC50 1.24 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3687418 IC50 1.24 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCC[C@@H](N)C5)c4)n[nH]c3cn2)cn1 CHEMBL3634759 Ki 1.25 nM
Cc1n[nH]c2cnc(-c3cncc(OCC(N)Cc4cccc(C(F)(F)F)c4)c3)cc12 CHEMBL1998159 pKi 1.259 nM
CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1/C=N/O CHEMBL3898395 IC50 1.27 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(NC3CCNCC3)n2)n1 CHEMBL3900258 Ki 1.28 nM
Cc1nc2cccc(-c3cc4c(=O)[nH]cnc4[nH]3)c2nc1NC(C)(C)C CHEMBL3934918 IC50 1.29 nM
O=C(Nc1c[nH]c2ccc(-c3c(F)cccc3F)cc12)c1cnn2ccc(NCC3CCNCC3)nc12 CHEMBL2387472 Ki 1.3 nM
Fc1ccccc1-c1ccc2[nH]nc(-c3cncc(O[C@H]4CNCCC45CC5)n3)c2c1 CHEMBL3393708 IC50 1.3 nM
C[C@@H]1CC[C@H](N)CN1c1ccncc1Nc1ncc2ccc(-c3ncccc3F)nn12 CHEMBL3963283 IC50 1.3 nM
N[C@@H]1CN(c2ccncc2Nc2ncc3ccc(-c4ncccc4F)nn23)C[C@H](N)[C@H]1O CHEMBL3904539 IC50 1.3 nM
C[C@@H]1C[C@H](N)CN(c2ccncc2Nc2ncc3ccc(-c4ccccn4)nn23)C1 CHEMBL4109355 IC50 1.3 nM
C[C@H]1CN(c2ccncc2Nc2ncc3ccc(-c4ncccc4F)nn23)C[C@@H](N)[C@@H]1O CHEMBL3942827 IC50 1.3 nM
C[C@@H]1CC[C@@H](N)CN1c1ccncc1Nc1ncc2ccc(-c3ncccc3F)nn12 CHEMBL4107310 IC50 1.3 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1C[C@@H](NCCS(C)(=O)=O)C1 CHEMBL3918797 IC50 1.3 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NCC(F)(F)F CHEMBL3916993 IC50 1.32 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C(C)(C)O)cc3F)n2)C[C@@H]1C CHEMBL3687507 IC50 1.33 nM
Cc1nc2cccc(-c3cc4c([nH]3)C3(CC3)NC4=O)c2nc1NCC(F)(F)F CHEMBL3973280 IC50 1.36 nM
Cc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCS(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687483 IC50 1.37 nM
Cc1nc2cccc(-c3cc4c([nH]3)C(CO)NC4=O)c2nc1NC1(C)CC1 CHEMBL3948398 IC50 1.37 nM
FCCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3942446 Ki 1.37 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C(C)C)cc3F)n2)C[C@@H]1C CHEMBL3687505 IC50 1.38 nM
Cc1cn([C@@H]2[C@H](N)CN(c3ccncc3NC(=O)c3ccc(F)c(-c4c(F)cccc4F)n3)C[C@@H]2C)nn1 CHEMBL3687420 IC50 1.39 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC(O)C3)n2)cn1 CHEMBL3937034 Ki 1.39 nM
CC(C)Nc1nnc(-c2ccc3[nH]cc(-c4nccc(C5CC5)n4)c3c2)o1 CHEMBL3919337 IC50 1.394 nM
CC(C)(C)Nc1cnc2cccc(-c3cc4n(c3)CCNC4=O)c2n1 CHEMBL3922362 IC50 1.4 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@@H](C)C1CC1 CHEMBL3980483 IC50 1.4 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1C[C@@H](O)C1 CHEMBL3977692 IC50 1.4 nM
Nc1ncc(-c2ccccc2F)nc1C(=O)Nc1cnccc1N1CCC(N)CC1 CHEMBL3895998 IC50 1.4 nM
c1cc(C2CC2)nc(-c2c[nH]c3ccc(-c4nnc(NC5CC5)o4)cc23)n1 CHEMBL3924862 IC50 1.41 nM
COC1(c2cccc(-n3ncc4cnc(-c5cncc(C)n5)cc43)n2)CCCNC1 CHEMBL3955604 Ki 1.43 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1OCCS(C)(=O)=O CHEMBL3687487 IC50 1.44 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnccc3C3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691916 IC50 1.45 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1NC(C)(C)CO CHEMBL3939819 IC50 1.45 nM
C#Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)C CHEMBL3929651 IC50 1.45 nM
CCOCc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@H](OC)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691920 IC50 1.47 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCCC4=O)c2nc1NC(C)(C)C CHEMBL3901863 IC50 1.47 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC(O)C3)n2)n1 CHEMBL3905519 Ki 1.47 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCC4(CNC4)C3)n2)n1 CHEMBL3983224 Ki 1.48 nM
N#CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3970981 Ki 1.49 nM
CS(=O)(=O)c1ccc(-c2ccc3[nH]nc(-c4cncc(O[C@H]5CNCCC56CC6)n4)c3c2)c(F)c1 CHEMBL3393719 IC50 1.5 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(C)CCCCC1 CHEMBL3918209 IC50 1.5 nM
COC(=O)N(C)[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C)cc3F)n2)C[C@@H]1C CHEMBL3687468 IC50 1.51 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1cncn1 CHEMBL3687466 IC50 1.51 nM
CNc1nnc(-c2ccc3[nH]cc(-c4nccc(N5CCC[C@H](N)C5)n4)c3c2)s1 CHEMBL3946212 IC50 1.527 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1Oc1ccccn1 CHEMBL3687532 IC50 1.53 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3639863 IC50 1.53 nM
C[C@H]1CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691978 IC50 1.54 nM
CCN(c1nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccc2c(=O)[nH]1)C(C)C CHEMBL3944889 IC50 1.54 nM
Cc1ccc(-n2ncc3cnc(-c4cnn(CC(F)(F)F)c4)cc32)nc1N1CCNC[C@@H](O)C1 CHEMBL4109699 Ki 1.54 nM
CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccccc3n2)CC1 CHEMBL565612 pKi 1.585 nM
N[C@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4ccccc4F)nn23)C1 CHEMBL3922469 IC50 1.6 nM
C[C@H]1CCN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C[C@H]1N CHEMBL3902228 IC50 1.6 nM
C[C@@H]1CCN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C[C@@H]1N CHEMBL4107702 IC50 1.6 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1Nc1ccccc1 CHEMBL3810085 IC50 1.6 nM
C[C@H]1NC(=O)c2cc(-c3cccc4cnc(NC5(C)CC5)nc34)[nH]c21 CHEMBL3935407 IC50 1.6 nM
c1cc(N2CCCNCC2)nc(-n2ncc3cnc(-c4cn[nH]c4)cc32)c1 CHEMBL3968789 Ki 1.6 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C[C@H]5CN(C)CCO5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4443684 IC50 1.6 nM
CC(C)NC(=O)c1ccc(F)c(-c2ccc(N)c(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](S(C)(=O)=O)[C@@H](C)C3)n2)c1 CHEMBL3687519 IC50 1.61 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)C CHEMBL3970766 IC50 1.63 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1NC(C)C CHEMBL3934338 IC50 1.64 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)ccc2N)c1N1CCCC(N)CC1 CHEMBL3652627 Ki 1.65 nM
CCOCc1cc(F)c(-c2nc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](NC(=O)OC)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691986 IC50 1.67 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4COC4)cc3F)n2)C[C@@H]1C CHEMBL3691946 IC50 1.68 nM
CC(C)Oc1cc(F)c(-c2nc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691931 IC50 1.69 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691956 IC50 1.69 nM
Fc1ccccc1-c1n[nH]c2cnc(-c3cnccc3O[C@@H]3CCCNC3)cc12 CHEMBL3634777 Ki 1.7 nM
CCO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H]1C CHEMBL3687481 IC50 1.7 nM
CC1CCCN1c1ccnc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3971473 IC50 1.7 nM
CCNc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1C CHEMBL3951627 IC50 1.7 nM
CCCCNc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1C CHEMBL3809623 IC50 1.7 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)CO CHEMBL3963838 IC50 1.7 nM
CC#Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3983351 Ki 1.71 nM
COCc1cn([C@@H]2[C@H](N)CN(c3ccncc3NC(=O)c3ccc(F)c(-c4c(F)cccc4F)n3)C[C@@H]2C)nn1 CHEMBL3687427 IC50 1.72 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)C[C@@H]1C CHEMBL3687508 IC50 1.72 nM
C#Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3890953 Ki 1.72 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1C[C@H](O)C1 CHEMBL3974822 IC50 1.73 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691977 IC50 1.79 nM
CCOCc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCS(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687534 IC50 1.79 nM
C[C@@H]1[C@@H](N)CCCN1c1ccncc1Nc1ncc2ccc(-c3ncccc3F)nn12 CHEMBL4115235 IC50 1.8 nM
Nc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1Oc1ccccc1 CHEMBL3934584 IC50 1.8 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)C(C)C CHEMBL3967917 IC50 1.8 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@H](C)NC4=O)c2nc1NC(C)(C)C CHEMBL3918714 IC50 1.8 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@H](CO)NC4=O)c2nc1NC1(C)CC1 CHEMBL3935312 IC50 1.82 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4COC4)cc3F)n2)C[C@@H](N)[C@H]1OCCC#N CHEMBL3691947 IC50 1.83 nM
c1cc(N2CCNCC2)nc(-n2ncc3cnc(-c4cncc(N5CCC5)n4)cc32)c1 CHEMBL3951741 Ki 1.83 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCS(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691928 IC50 1.86 nM
Cc1nc2cccc(-c3cc4c([nH]3)C(COCc3ccccc3)NC4=O)c2nc1NC1(C)CC1 CHEMBL3934242 IC50 1.86 nM
COc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3917077 Ki 1.87 nM
CC(C)Nc1nnc(-c2cc3c(-c4nccc(C5CC5)n4)c[nH]c3cc2F)o1 CHEMBL3965588 IC50 1.88 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3691961 IC50 1.89 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 Kd 1.9 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691944 IC50 1.9 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CC(O)C1 CHEMBL3905697 IC50 1.9 nM
Cc1nc2cccc(-c3cc4c([nH]3)CNC4=O)c2nc1NCC(F)(F)F CHEMBL3961776 IC50 1.91 nM
Cc1nc2cccc(-c3cc4c([nH]3)C(C)(C)NC4=O)c2nc1NC(C)(C)C CHEMBL3897690 IC50 1.93 nM
CC(C)c1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](N)C3)n2)c1 CHEMBL3952845 Ki 1.93 nM
C[C@@H](O)c1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)C CHEMBL3899014 IC50 1.95 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)C12OCCO2 CHEMBL3687452 IC50 1.96 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(F)CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3687536 IC50 1.98 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(NC5CCCC5)n4)c3c2)o1 CHEMBL3917311 IC50 1.997 nM
CN(C)Cc1nc2c(sc3ccc(/C=C/C4CC4)cc32)c(=O)[nH]1 CHEMBL576387 Ki 2.0 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccc(N)cc4)cc32)c(=O)[nH]1 CHEMBL574169 Ki 2.0 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccsc4)cc32)c(=O)[nH]1 CHEMBL575263 Ki 2.0 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccc(OCC(O)CO)cc4)cc32)c(=O)[nH]1 CHEMBL575463 Ki 2.0 nM
O=c1[nH]c(CN2CC[C@H](O)C2)nc2c1sc1ccc(-c3ccc(O)cc3)cc12 CHEMBL583187 Ki 2.0 nM
CCNC(=O)c1cccc2c1nc(Nc1ccccc1Cl)c1ccncc12 CHEMBL1915646 IC50 2.0 nM
CC(C)NC(=O)c1cccc2c1nc(Nc1ccccc1Cl)c1ccncc12 CHEMBL1915647 IC50 2.0 nM
CNC(=O)c1cccc2c1nc(Nc1c(F)cccc1F)c1ccncc12 CHEMBL1914471 IC50 2.0 nM
Clc1ccccc1Nc1nc2c(-c3nnc[nH]3)cccc2c2sccc12 CHEMBL2017323 IC50 2.0 nM
Fc1ccccc1Nc1nc2c(-c3nnc[nH]3)cccc2c2sccc12 CHEMBL2017324 IC50 2.0 nM
Fc1ccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3sccc23)c(F)c1 CHEMBL2017348 IC50 2.0 nM
O=C(Nc1c[nH]c2ncccc12)c1cnn2ccc(NC[C@@H]3CCNC[C@H]3F)nc12 CHEMBL2387479 Ki 2.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@H](O)[C@@H](C)C3)ccc2F)c1F CHEMBL3651940 IC50 2.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3cc(O)ccc3F)n2)C1 CHEMBL3651942 IC50 2.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2cccc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3651922 IC50 2.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@H](O)[C@@H](C)C3)ccc2F)c1F CHEMBL3651918 IC50 2.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2cccc(-c3c(F)cccc3F)n2)C[C@@H](O)[C@@H]1O CHEMBL3652009 IC50 2.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3ccccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3651921 IC50 2.0 nM
COc1cc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)C[C@@H](C(F)(F)F)C3)n2)c(F)c1 CHEMBL3652003 IC50 2.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cc(O)cc3F)ccc2F)C1 CHEMBL3651938 IC50 2.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C1 CHEMBL3651947 IC50 2.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)ccc(O)c3F)n2)C1 CHEMBL3652018 IC50 2.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2F)C[C@@H](N)[C@@H]1O CHEMBL3651920 IC50 2.0 nM
COc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)C[C@H](N)C3)ccc2F)c1 CHEMBL3651941 IC50 2.0 nM
CC1(C)C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(O)cc3F)n2)C1 CHEMBL3652016 IC50 2.0 nM
CCCNc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1C CHEMBL3808459 IC50 2.0 nM
C[C@@H]1C[C@H](N)CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676284 IC50 2.0 nM
CN1CCN(Cc2ccc(-c3c(-c4cccc(OC(F)(F)F)c4)cc4n3[C@@H](CCN)CNC4=O)cc2)CC1 CHEMBL3912707 IC50 2.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CC1 CHEMBL3976162 IC50 2.0 nM
Cn1c(Nc2ccccc2)nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2c1=O CHEMBL3913376 IC50 2.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H](C)C1CC1 CHEMBL3904800 IC50 2.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1C[C@@H](NCC(F)F)C1 CHEMBL3926975 IC50 2.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1N[C@H]1CCC[C@@H](NS(C)(=O)=O)C1 CHEMBL3907991 IC50 2.0 nM
COC[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3961876 IC50 2.0 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCCC(O)CC1 CHEMBL4472966 Ki 2.0 nM
Cc1cn([C@H](C)[C@H]2CCNC[C@@H]2F)c2nc(C(N)=O)cc(Cl)c12 CHEMBL4750046 IC50 2.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(F)CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691935 IC50 2.04 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)C[C@@H](N)[C@H]1OCCC#N CHEMBL3691968 IC50 2.04 nM
CC1CCCCN1c1cncc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3980131 IC50 2.063 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(NCC5CC5)n4)c3c2)o1 CHEMBL3890140 IC50 2.067 nM
Cc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691965 IC50 2.1 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CCCOC1 CHEMBL3980526 IC50 2.1 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N(C)C(C)(C)C CHEMBL3925198 IC50 2.1 nM
Cc1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccn2c1=O CHEMBL4522524 IC50 2.1 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)cnc2N)c1N1CCC[C@H](N)C1 CHEMBL3652630 Ki 2.13 nM
COC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H]1C CHEMBL3691959 IC50 2.15 nM
CC(C)Nc1nnc(-c2ccc3[nH]cc(-c4ncc(C(N)=O)c(C5CC5)n4)c3c2)o1 CHEMBL3981514 IC50 2.15 nM
Cc1nc2cccc(-c3cc4c([nH]3)C(CO)NC4=O)c2nc1NC(C)(C)C CHEMBL3936412 IC50 2.16 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C)cc3F)n2)C[C@@H]1C CHEMBL3687512 IC50 2.18 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2nc(-c3cc(C(=O)NC(C)C)ccc3F)ccc2N)C[C@@H]1C CHEMBL3639908 IC50 2.18 nM
Cc1nc2cccc(-c3cc4c([nH]3)C(COCc3ccccc3)NC4=O)c2nc1NC1CC1 CHEMBL3933159 IC50 2.18 nM
CC1CCCCN1c1ccnc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3932794 IC50 2.186 nM
O=C(Nc1c[nH]c2ncccc12)c1cnn2ccc(NCCc3ccccc3)nc12 CHEMBL2387469 Ki 2.2 nM
Cn1cc(-c2cc3c(-c4cccc(C5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3634768 Ki 2.2 nM
CCOCc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691939 IC50 2.2 nM
C[C@]1(N)CCCN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C1 CHEMBL3974415 IC50 2.2 nM
O=C1NCCn2cc(-c3cccc4ccc(Nc5cccnc5)nc34)cc21 CHEMBL3906821 IC50 2.2 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(CC(C)(C)N)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4445845 IC50 2.2 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=O)c2nc1NCC(F)(F)F CHEMBL3903517 IC50 2.23 nM
CC(C)Nc1ccnc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3908000 IC50 2.236 nM
CC(C)Nc1nnc(-c2ccc3[nH]cc(-c4cc(=O)[nH]c(C5CC5)n4)c3c2)o1 CHEMBL3913006 IC50 2.24 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)C(F)(F)F CHEMBL3966076 IC50 2.24 nM
CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1Cl CHEMBL3918158 IC50 2.25 nM
COc1ccc(-n2ncc3cnc(-c4cnn(CC(F)(F)F)c4)cc32)nc1N1CCNC[C@@H](O)C1 CHEMBL4115539 Ki 2.25 nM
Cc1cn(-c2cccc(-c3c[nH]c4ccc(-c5nnc(N)s5)cc34)n2)cn1 CHEMBL3901582 IC50 2.254 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(N5CCC(F)(F)CC5)n4)c3c2)o1 CHEMBL3904783 IC50 2.256 nM
CCO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C)cc3F)n2)C[C@@H]1C CHEMBL3687501 IC50 2.26 nM
CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1CO CHEMBL3891786 IC50 2.26 nM
FC(F)Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3916902 Ki 2.26 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CC[C@H](N)C3)n2)n1 CHEMBL3943759 Ki 2.27 nM
CCNc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3891387 Ki 2.28 nM
CC1(C)CCCCN1c1cnc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3935709 IC50 2.3 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)[C@@H]([C@H](C)O)NC4=O)c2nc1NC1CC1 CHEMBL3939783 IC50 2.3 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)C[C@@H](N)[C@H]1S(C)(=O)=O CHEMBL3687518 IC50 2.34 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4CCS(=O)(=O)CC4)cc3F)n2)C[C@@H]1C CHEMBL3687504 IC50 2.35 nM
CCO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687498 IC50 2.37 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(C3(F)CCCNC3)n2)n1 CHEMBL3909947 Ki 2.37 nM
Nc1nnc(-c2ccc3[nH]cc(-c4nccc(OCC(F)(F)F)n4)c3c2)o1 CHEMBL3971664 IC50 2.378 nM
CC(=O)N[C@@H]1CCC[C@H](Nc2nc3c(-c4cc5c([nH]4)[C@@H](C)NC5=O)cccc3nc2C)C1 CHEMBL3919258 IC50 2.38 nM
CC(C)(C)Nc1nnc(-c2ccc3[nH]cc(-c4nccc(C5CC5)n4)c3c2)o1 CHEMBL3969942 IC50 2.395 nM
CCC1CNC(=O)c2cc(-c3cccc4ccc(Nc5ccccc5)nc34)[nH]c21 CHEMBL3902525 IC50 2.4 nM
CC1CNC(=O)c2cc(-c3cccc4ccc(Nc5ccccc5)nc34)[nH]c21 CHEMBL3933369 IC50 2.4 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CCNCC1 CHEMBL3901085 IC50 2.4 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(F)CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3687506 IC50 2.42 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNC(C)CC3)n2)n1 CHEMBL3895531 Ki 2.42 nM
Cc1nc2ccc(F)c(-c3cc4c([nH]3)[C@H]([C@@H](C)O)NC4=O)c2nc1NC1CC1 CHEMBL3918771 IC50 2.45 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(F)CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1OCCS(C)(=O)=O CHEMBL3691913 IC50 2.46 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H](N)[C@H]1S(C)(=O)=O CHEMBL3687525 IC50 2.48 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)ccc2N)c1N1CCC[C@@H](N)C1 CHEMBL3652625 Ki 2.49 nM
Cc1nc2cccc(-c3cc4c(s3)C(=O)NC4)c2nc1NC(C)(C)C CHEMBL4527131 IC50 2.5 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3687414 IC50 2.53 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCS(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691914 IC50 2.54 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=S)c2nc1NC(C)(C)C CHEMBL3934590 IC50 2.54 nM
C[C@H]1CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691915 IC50 2.55 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3C[C@@H](N)C[C@@H](F)C3)n2)n1 CHEMBL4113302 Ki 2.55 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3cc(C(=O)NC(C)C)ccc3F)ccc2N)C[C@@H]1C CHEMBL3687535 IC50 2.56 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ncc2N)C[C@@H]1C CHEMBL3687489 IC50 2.57 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1NS(C)(=O)=O CHEMBL3687431 IC50 2.59 nM
CC(C)NC(=O)c1ccc(F)c(-c2ccc(N)c(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)n2)c1 CHEMBL3691980 IC50 2.6 nM
N[C@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4ncccc4Cl)nn23)C1 CHEMBL3920733 IC50 2.6 nM
CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2c(=O)n1-c1cccnc1 CHEMBL3978132 IC50 2.6 nM
OCCOc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3961360 Ki 2.62 nM
OCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3919520 Ki 2.63 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC4(CNC4)C3)n2)n1 CHEMBL3907320 Ki 2.65 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC)cc3F)n2)C[C@@H]1C CHEMBL3691957 IC50 2.67 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@@H](O)C3)n2)n1 CHEMBL4107092 Ki 2.68 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC4CCOCC4)cc3F)n2)C[C@@H](N)[C@@H]1OCCS(C)(=O)=O CHEMBL3691924 IC50 2.69 nM
NC(=O)c1cc(Cl)c2c(Cl)c(C#CCCO)n([C@H]3CCCNC3)c2n1 CHEMBL4448325 IC50 2.7 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@@H](C)NC4=S)c2nc1NC(C)(C)C CHEMBL3931370 IC50 2.76 nM
CC(C)c1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)c1 CHEMBL3975764 Ki 2.76 nM
CC(C)Nc1nnc(-c2ccc3[nH]cc(-c4ncc(F)c(C5CC5)n4)c3c2)o1 CHEMBL3947201 IC50 2.77 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(-c5cccnc5)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3912577 IC50 2.77 nM
CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1F CHEMBL3909227 IC50 2.78 nM
C=C(C)c1cn([C@@H]2[C@H](N)C[C@H](c3ccncc3NC(=O)c3ccc(F)c(-c4c(F)cccc4F)n3)C[C@@H]2C)nn1 CHEMBL3691971 IC50 2.79 nM
N#Cc1ccc(Cc2cc(O)n3ncc(C(=O)Nc4c[nH]c5ncccc45)c3n2)cc1 CHEMBL2387468 Ki 2.8 nM
C[C@H]1CC[C@@H](N)CN1c1ccncc1Nc1ncc2ccc(-c3ncccc3F)nn12 CHEMBL3933147 IC50 2.8 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Nc5cncnc5)nc34)cc21 CHEMBL3967572 IC50 2.8 nM
O=C1NCCc2[nH]c(-c3cccc4ncc(Nc5ccccc5)nc34)cc21 CHEMBL3899005 IC50 2.8 nM
CC[C@H]1CNC(=O)c2cc(-c3cccc4ccc(Nc5ccccc5)nc34)[nH]c21 CHEMBL3973604 IC50 2.8 nM
CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1C(F)(F)F CHEMBL3916196 IC50 2.8 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NCC1(C)COC1 CHEMBL3894496 IC50 2.8 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(F)CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3691982 IC50 2.81 nM
CC(C)c1ccnc(-c2c[nH]c3ccc(-c4nnc(NCC#N)o4)cc23)n1 CHEMBL3956256 IC50 2.826 nM
CN1CCCC(Oc2ccnc(-c3c[nH]c4ccc(-c5nnc(N)o5)cc34)n2)C1 CHEMBL3912113 IC50 2.853 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C)cc3F)n2)C[C@@H]1C CHEMBL3687472 IC50 2.9 nM
N[C@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4nccs4)nn23)C1 CHEMBL3910008 IC50 2.9 nM
Nc1cccc(Nc2ccc3cccc(-c4cc5c([nH]4)CCNC5=O)c3n2)c1 CHEMBL3986342 IC50 2.9 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@@H]1CC[C@@H]1N CHEMBL3910979 IC50 2.9 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC4(CCCN4)CC3)n2)n1 CHEMBL3981915 Ki 2.95 nM
CC(C)Nc1nnc(-c2ccc3[nH]cc(-c4nc(C(N)=O)cc(C5CC5)n4)c3c2)o1 CHEMBL3941198 IC50 2.959 nM
N[C@H]1CCC[C@@H]1Nc1cncc(-c2cc3c(cn2)cnn3-c2ccccn2)n1 CHEMBL3915913 Ki 2.97 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccc(O)cc4)cc32)c(=O)[nH]1 CHEMBL585182 Ki 3.0 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccc[nH]4)cc32)c(=O)[nH]1 CHEMBL572783 Ki 3.0 nM
CN(C)Cc1nc2c(sc3ccc(-c4cccnc4)cc32)c(=O)[nH]1 CHEMBL575461 Ki 3.0 nM
O=c1[nH]c(CN2CC[C@H](O)C2)nc2c1sc1ccc(-c3ccsc3)cc12 CHEMBL573012 Ki 3.0 nM
Fc1ccccc1Nc1nc2c(-c3nnc[nH]3)cccc2c2cnccc12 CHEMBL1915442 IC50 3.0 nM
Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(OC4CNCCC45CC5)n3)c2c1 CHEMBL3393704 IC50 3.0 nM
NC1CCN(c2cncc(-c3cc4c(-c5ccccc5F)n[nH]c4cn3)n2)CC1 CHEMBL3634779 Ki 3.0 nM
NCCNc1cccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)n1 CHEMBL3634780 Ki 3.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(C3CCCCC3)n2)C[C@@H](N)[C@@H]1O CHEMBL3651912 IC50 3.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)ccc(F)c3F)n2)C1 CHEMBL3652023 IC50 3.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2cccc(-c3c(F)cccc3F)n2)C1 CHEMBL3651959 IC50 3.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3ccccc3F)n2)C[C@@H](O)[C@@H]1O CHEMBL3652008 IC50 3.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](O)[C@@H](C)C3)ccc2F)c1F CHEMBL3651936 IC50 3.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2cccc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3651948 IC50 3.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3651946 IC50 3.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)C[C@H](N)C3)ccc2F)c1 CHEMBL3651955 IC50 3.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)C[C@H](N)C3)ccc2F)c1F CHEMBL3651923 IC50 3.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2cccc(-c3c(F)cc(O)cc3F)n2)C1 CHEMBL3651932 IC50 3.0 nM
CC1(C)C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C1 CHEMBL3651945 IC50 3.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1O CHEMBL3651981 IC50 3.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)C[C@@H](N)[C@H]1O CHEMBL3651989 IC50 3.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2cccc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1O CHEMBL3651972 IC50 3.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1S(C)(=O)=O CHEMBL3687447 IC50 3.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(O)cc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3651900 IC50 3.0 nM
N[C@@H]1CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)CC[C@@H]1O CHEMBL3676262 IC50 3.0 nM
NC1CC(C(F)(F)F)CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676271 IC50 3.0 nM
NC1CC(CF)CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676272 IC50 3.0 nM
CC[C@@H]1C[C@H](N)CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676281 IC50 3.0 nM
N[C@H]1C[C@@H](C(F)(F)F)CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676283 IC50 3.0 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@@H]1CCC[C@H](N)C1 CHEMBL3676289 IC50 3.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3676292 IC50 3.0 nM
CS(=O)(=O)c1ccc(-c2c(-c3cccc(OC(F)(F)F)c3)cc3n2[C@@H](CCN)CNC3=O)cc1 CHEMBL3949477 IC50 3.0 nM
NCC[C@H]1CNC(=O)c2cc(-c3cccc(OC(F)(F)F)c3)c(-c3ccc(S(N)(=O)=O)cc3)n21 CHEMBL3973012 IC50 3.0 nM
NCC[C@H]1CNC(=O)c2cc(-c3cccc(OC(F)(F)F)c3)c(-c3ccc(C4(N)CC4)cc3)n21 CHEMBL3957977 IC50 3.0 nM
N[C@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4ccccc4Cl)nn23)C1 CHEMBL3924352 IC50 3.0 nM
N[C@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4ccc(F)cc4F)nn23)C1 CHEMBL3931386 IC50 3.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1CCNC1 CHEMBL3910145 IC50 3.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(CO)CCC1 CHEMBL3916316 IC50 3.0 nM
C[C@H](O)c1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)C CHEMBL3923557 IC50 3.0 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCN(C)CC5)n4)n[nH]c3cn2)cn1 CHEMBL3956461 Ki 3.0 nM
Cc1cn([C@H](C)[C@@H]2CCNC[C@H]2F)c2nc(C(N)=O)cc(Cl)c12 CHEMBL4745141 IC50 3.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3ncccc3F)ccc2N)C[C@@H](O)[C@]1(C)O CHEMBL4781112 Ki 3.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C[C@@H](O)[C@]1(C)O CHEMBL4783935 Ki 3.0 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC(C)C)cc3F)n2)C[C@@H]1C CHEMBL3687511 IC50 3.01 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@H](OC)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691927 IC50 3.02 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC4CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1OCCC#N CHEMBL3691967 IC50 3.08 nM
Nc1nnc(-c2ccc3[nH]cc(-c4nccc(Nc5ccccc5)n4)c3c2)o1 CHEMBL3899404 IC50 3.099 nM
C[C@]12O[C@H](C[C@H](O)[C@H]1O)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4=O CHEMBL4444272 Kd 3.1 nM
COCC1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3894748 IC50 3.12 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC(N)CC3)n2)n1 CHEMBL3966696 Ki 3.12 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)ccc2N)c1N1CCC[C@H](N)CC1 CHEMBL3652640 Ki 3.13 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 3.162 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691963 IC50 3.19 nM
N[C@H]1C[C@@H](F)CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C1 CHEMBL3913112 IC50 3.2 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Nc5c(F)cccc5F)nc34)cc21 CHEMBL3916900 IC50 3.2 nM
CC1(C)COCCN1c1cnc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3963777 IC50 3.2 nM
C[C@H](c1cn(C)cn1)n1c(NC2(C)CC2)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccc2c1=O CHEMBL4463004 IC50 3.2 nM
c1cc(C2CC2)nc(-c2c[nH]c3ccc(-c4nnc(NC5COC5)o4)cc23)n1 CHEMBL3952561 IC50 3.204 nM
CN(C)[C@H]1CCCN(c2ccnc(-c3c[nH]c4ccc(-c5nnc(N)o5)cc34)n2)C1 CHEMBL3973417 IC50 3.243 nM
CCOCc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OC)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687510 IC50 3.3 nM
CN(c1ncc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1)C(C)(C)C CHEMBL3982591 IC50 3.32 nM
CCn1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)c1=O CHEMBL3947770 Ki 3.32 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3C[C@@H](N)C[C@H](F)C3)n2)n1 CHEMBL3975198 Ki 3.35 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687485 IC50 3.37 nM
Cc1nc2cccc(-c3cc4c([nH]3)C[C@@H](C)NC4=O)c2nc1NC(C)(C)C CHEMBL3959102 IC50 3.37 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)c1 CHEMBL3939394 Ki 3.37 nM
OC1CN(c2cncc(-c3cc4c(cn3)cnn4-c3cccc(N4CCNCC4)n3)n2)C1 CHEMBL3975756 Ki 3.37 nM
Cc1nc2cccc(-c3[nH]c4c(c3C)C(=O)NCC4)c2nc1NC(C)(C)C CHEMBL3986680 IC50 3.38 nM
CNc1cccc(-n2ncc3cnc(-c4cncc(C)n4)cc32)n1 CHEMBL3931274 Ki 3.43 nM
Cc1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](N)C3)n2)sn1 CHEMBL3973544 Ki 3.48 nM
Cc1nc2cccc(-c3cc4n(c3)CCNC4=O)c2nc1NC(C)(C)C CHEMBL3913500 IC50 3.5 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CCCC(O)C1 CHEMBL3976306 IC50 3.5 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C(C)(C)C)c(NC5(C)CC5)nc34)[nH]c21 CHEMBL4573829 IC50 3.5 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)cnc2N)c1N1CCC[C@@H](N)CC1 CHEMBL3652639 Ki 3.52 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1S(=O)(=O)CCO CHEMBL3639862 IC50 3.56 nM
Cc1nc2ccc(F)c(-c3cc(C(N)=O)c(C)[nH]3)c2nc1NC1(C)CC1 CHEMBL3891362 IC50 3.56 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC(O)C(O)C3)n2)n1 CHEMBL3965243 Ki 3.58 nM
CC(C)(C)Nc1ncc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3972296 IC50 3.62 nM
COc1ccc(-n2ncc3cnc(-c4cncc(C)n4)cc32)nc1N1CCNCC(O)C1 CHEMBL3893598 Ki 3.67 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OC)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687503 IC50 3.68 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@H](CO)NC4=O)c2nc1NC1CC1 CHEMBL3917695 IC50 3.68 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cccc(N5CCCC[C@@H]5N)n4)c3c2)s1 CHEMBL4108864 IC50 3.702 nM
Cc1nc2cccc(-c3cc4c(=O)[nH]ncc4[nH]3)c2nc1NC(C)(C)C CHEMBL3953807 IC50 3.71 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](NC(=O)OC)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687515 IC50 3.74 nM
CC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1C#N CHEMBL3926451 IC50 3.76 nM
Cc1nc2cccc(-c3cc4c([nH]3)C3(CC3)CNC4=O)c2nc1NC1CC1 CHEMBL3889626 IC50 3.8 nM
Cc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](S(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687531 IC50 3.85 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)c1 CHEMBL3901481 Ki 3.86 nM
Nc1nnc(-c2ccc3[nH]cc(-c4nccc(-c5ccccc5)n4)c3c2)o1 CHEMBL3965031 IC50 3.866 nM
c1cc(N2CCCNCC2)nc(-n2ncc3cnc(-c4cncc(C5CC5)c4)cc32)c1 CHEMBL3951088 Ki 3.87 nM
C[C@@H]1C[C@H](N)CN(c2ccncc2Nc2nnc3ccc(-c4c(F)cccc4F)nn23)C1 CHEMBL4108287 IC50 3.9 nM
O=C1NCCc2[nH]c(-c3c(F)ccc4ccc(Nc5ccccc5)nc34)cc21 CHEMBL3964527 IC50 3.9 nM
c1cc(N2CCCNCC2)nc(-n2ncc3cnc(-c4cnn(C5CCC5)c4)cc32)c1 CHEMBL3944757 Ki 3.92 nM
Cc1nc2cccc(-c3cc4c([nH]3)C[C@H](C)NC4=O)c2nc1NC(C)(C)C CHEMBL3930939 IC50 3.96 nM
Nc1ccc(-c2cncc(OCC(N)Cc3c[nH]c4ccccc34)c2)cc1C(=O)c1ccccc1 CHEMBL1972125 pKi 3.981 nM
FC(F)c1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3957997 Ki 3.99 nM
CN(C)Cc1nc2c(sc3ccc(-c4cccc(O)c4)cc32)c(=O)[nH]1 CHEMBL583913 Ki 4.0 nM
N[C@H]1CC[C@@H](Nc2cc(Br)cc3cc(C(=O)O)oc23)CC1 CHEMBL1782530 IC50 4.0 nM
CNC(=O)c1cccc2c1nc(Nc1ccccc1F)c1ccncc12 CHEMBL1915650 IC50 4.0 nM
NC(=O)c1cccc2c1nc(Nc1c(F)cccc1F)c1ccncc12 CHEMBL1915651 IC50 4.0 nM
Oc1ccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3sccc23)c(Cl)c1 CHEMBL2017341 IC50 4.0 nM
Fc1ncccc1-c1ccc2[nH]nc(-c3cncc(O[C@H]4CNCCC45CC5)n3)c2c1 CHEMBL3393713 IC50 4.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3ccc(O)cc3F)n2)C1 CHEMBL3651934 IC50 4.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@@H]3C[C@H](N)C[C@H](N)C3)n2)c1F CHEMBL3651925 IC50 4.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3ccncc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3652013 IC50 4.0 nM
COc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@H](O)[C@@H](C)C3)ccc2F)c1F CHEMBL3651943 IC50 4.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3ccccc3F)n2)C1 CHEMBL3651953 IC50 4.0 nM
Nc1cc(F)c(-c2ccccc2F)nc1C(=O)Nc1cnccc1[C@@H]1CC[C@H](O)[C@H](N)C1 CHEMBL3651962 IC50 4.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(O)cc3F)n2)C1 CHEMBL3651928 IC50 4.0 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)CC(C)(C)C3)ccc2F)c(F)c1 CHEMBL3652017 IC50 4.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@H](O)[C@@H](C)C3)n2)c1F CHEMBL3651909 IC50 4.0 nM
Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@@H]1CC[C@H](O)[C@H](N)C1 CHEMBL3651996 IC50 4.0 nM
Nc1cc(F)c(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@@H]1CC[C@H](O)[C@H](N)C1 CHEMBL3651961 IC50 4.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2cccc(-c3c(F)cc(O)cc3F)n2)C1 CHEMBL3651904 IC50 4.0 nM
Nc1ccc(C2CCCCC2)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 CHEMBL3747207 Ki 4.0 nM
Cc1cc(-c2ccncc2NC(=O)c2nc(-c3ccccc3F)ccc2N)cc(N)n1 CHEMBL3792742 Ki 4.0 nM
COc1cc(-c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)cc(N)n1 CHEMBL3794146 Ki 4.0 nM
CC1CC(N)CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676270 IC50 4.0 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@@H]1CC[C@H](O)[C@H](N)C1 CHEMBL3676294 IC50 4.0 nM
COc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)C[C@H](N)C3)cs2)c1F CHEMBL3676305 IC50 4.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2csc(-c3c(F)cc(O)cc3F)n2)C1 CHEMBL3676310 IC50 4.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3949174 IC50 4.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1C[C@@H](N(C)C)C1 CHEMBL3889998 IC50 4.0 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCOCC5)n4)n[nH]c3cn2)cn1 CHEMBL3915064 Ki 4.0 nM
COCC(C)(C)C#Cc1c(Cl)c2c(Cl)cc(C(N)=O)nc2n1[C@H]1CCCNC1 CHEMBL4457529 IC50 4.0 nM
C[C@@H]1C[C@H](O)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C1 CHEMBL3651898 Ki 4.0 nM
CC(C)Nc1cncc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3912741 IC50 4.025 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@H](OC)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687533 IC50 4.03 nM
c1cc(N2CCNCC2)nc(-n2ncc3cnc(-c4cncs4)cc32)c1 CHEMBL3953990 Ki 4.03 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1cc(C2CC2)nn1 CHEMBL3691970 IC50 4.05 nM
Cn1c(NC(C)(C)C)nc2c(-c3cc4n(c3)CCNC4=O)cccc2c1=O CHEMBL3962885 IC50 4.05 nM
CNc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1C CHEMBL3972842 IC50 4.1 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](O)C3)n2)n1 CHEMBL3906421 Ki 4.17 nM
CC(C)Nc1nnc(-c2ccc3[nH]cc(-c4cncc(C5CC5)n4)c3c2)o1 CHEMBL3932201 IC50 4.252 nM
C=Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3947309 Ki 4.26 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3907004 Ki 4.27 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1cc(-c2ccsc2)nn1 CHEMBL3687417 IC50 4.28 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](N)C3=O)n2)n1 CHEMBL3952360 Ki 4.29 nM
c1ccc(-c2ccc3[nH]nc(-c4cncc(O[C@H]5CNCCC56CC6)n4)c3c2)cc1 CHEMBL3393709 IC50 4.3 nM
CCN(c1ccccc1)c1cnc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3983065 IC50 4.3 nM
CC1CNC(=O)c2cc(-c3cccc4ncc(Nc5ccccc5)nc34)[nH]c21 CHEMBL3980066 IC50 4.3 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1SC(C)(C)C CHEMBL3900670 IC50 4.3 nM
c1ccc(-n2ncc3cnc(-c4cncc(NC5CNC5)n4)cc32)nc1 CHEMBL3985665 Ki 4.31 nM
c1cc(C2CC2)nc(-c2c[nH]c3ccc(-c4nnc(C5CC5)o4)cc23)n1 CHEMBL3947565 IC50 4.317 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H](C)C(F)(F)F CHEMBL3978345 IC50 4.32 nM
CN[C@H]1CCCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC1 CHEMBL3652645 Ki 4.37 nM
CN(c1ccccc1)c1cnc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3904349 IC50 4.4 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691976 IC50 4.42 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CCCCC1O CHEMBL3964978 IC50 4.5 nM
N[C@@H]1CCCN(c2cccc(-n3ncc4cnc(-c5cncs5)cc43)n2)C1 CHEMBL4106584 Ki 4.5 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](N)C3)n2)cn1 CHEMBL3963946 Ki 4.56 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@H](C)NC4=O)c2nc1NCC(F)F CHEMBL3961097 IC50 4.57 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNC[C@@H](O)C3)n2)c1 CHEMBL4111637 Ki 4.59 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Nc5ccccc5F)nc34)cc21 CHEMBL3968570 IC50 4.6 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Oc5cccnc5)nc34)cc21 CHEMBL3975293 IC50 4.6 nM
N[C@@H]1CCC[C@@H](Nc2ccc3cccc(-c4cc5c([nH]4)CCNC5=O)c3n2)C1 CHEMBL3935691 IC50 4.6 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CC(F)(F)C1 CHEMBL3903663 IC50 4.6 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(C3CCNCC3)n2)n1 CHEMBL3931279 Ki 4.62 nM
O[C@@H]1CNCCN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)C1 CHEMBL4113332 Ki 4.64 nM
CC(C)Nc1nnc(-c2ccc3[nH]cc(-c4ccnc(C5CC5)n4)c3c2)o1 CHEMBL3895040 IC50 4.65 nM
Cc1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)sn1 CHEMBL3985111 Ki 4.66 nM
OCC(O)c1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3933868 Ki 4.67 nM
C[C@H]1CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H](N)[C@H]1C#N CHEMBL3687464 IC50 4.68 nM
C=C(C)CNc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1C CHEMBL3949181 IC50 4.7 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Oc5c(F)cccc5F)nc34)cc21 CHEMBL3908049 IC50 4.7 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687502 IC50 4.71 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CC[C@@H](N)C3)n2)n1 CHEMBL4111423 Ki 4.74 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(N5CCCCC5)n4)c3c2)o1 CHEMBL3930832 IC50 4.765 nM
C[C@H]1CCCN(c2ccnc(-c3c[nH]c4ccc(-c5nnc(N)o5)cc34)n2)C1 CHEMBL3970168 IC50 4.807 nM
CO/N=C1\[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687426 IC50 4.82 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(C5CC5)n4)c3c2)o1 CHEMBL3896794 IC50 4.849 nM
O=C(Nc1c[nH]c2ncccc12)c1cnn2ccc(NCC3(F)CCNCC3)nc12 CHEMBL2387462 Ki 4.9 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CCCCC1 CHEMBL3986516 IC50 4.9 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)C CHEMBL3890648 IC50 4.9 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(CC(C)(C)C)nc34)[nH]c21 CHEMBL4559238 IC50 4.9 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccc(O)c(F)c4)cc32)c(=O)[nH]1 CHEMBL572514 Ki 5.0 nM
CN(C)Cc1nc2c(sc3ccc(N4CCCC4)cc32)c(=O)[nH]1 CHEMBL573957 Ki 5.0 nM
CNC(=O)c1cccc2c1nc(Nc1cccc(OC)c1Cl)c1ccncc12 CHEMBL1915645 IC50 5.0 nM
CC(C)CNC(=O)c1cccc2c1nc(Nc1ccccc1Cl)c1ccncc12 CHEMBL1915648 IC50 5.0 nM
Fc1cccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3sccc23)c1 CHEMBL2017346 IC50 5.0 nM
C#Cc1cccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3sccc23)c1 CHEMBL2017356 IC50 5.0 nM
CN1CCCN(C(=O)c2ccc(F)c(-c3ccc(/C=C4/C(=O)Nc5ccc(Cl)cc54)o3)c2)CC1 CHEMBL2037204 IC50 5.0 nM
N[C@@H]1CCCN(c2c(Cl)cccc2/C=C2\SC(=O)NC2=O)C1 CHEMBL2048866 IC50 5.0 nM
COc1cccc(/C=C2\SC(=O)NC2=O)c1N1CCC[C@@H](N)C1 CHEMBL2048868 IC50 5.0 nM
Fc1ccncc1-c1ccc2[nH]nc(-c3cncc(O[C@H]4CNCCC45CC5)n3)c2c1 CHEMBL3393711 IC50 5.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@H]1O CHEMBL3652025 IC50 5.0 nM
C[C@@H]1C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)C[C@H](N)[C@H]1O CHEMBL3651990 IC50 5.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1F CHEMBL3652031 IC50 5.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3cccc(F)c3F)n2)C1 CHEMBL3651956 IC50 5.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C1 CHEMBL3651993 IC50 5.0 nM
N[C@@H]1C[C@H](c2ccncc2NC(=O)c2ccc(F)c(C3CCCCC3)n2)C[C@H](C(F)(F)F)C1 CHEMBL3652005 IC50 5.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)CC(C)(C)C3)ccc2F)c1F CHEMBL3651907 IC50 5.0 nM
C[C@@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)C[C@@H](N)[C@H]1O CHEMBL3651992 IC50 5.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2cccc(-c3ccccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3651919 IC50 5.0 nM
N[C@H]1CCCN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676258 Ki 5.0 nM
C[C@@H]1C[C@H](O)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C1 CHEMBL3676288 IC50 5.0 nM
COc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)C CHEMBL3919294 IC50 5.0 nM
COC[C@@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3922440 IC50 5.0 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCCNCC1 CHEMBL4458081 Ki 5.0 nM
N[C@H]1CCCN(c2c(/C=C3\SC(=O)NC3=O)cccc2-c2ccccc2)C1 CHEMBL4793492 IC50 5.0 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3892509 Ki 5.01 nM
FC(F)(F)Cn1cc(-c2cc3c(cn2)cnn3-c2ccnc(N3CCCNCC3)n2)cn1 CHEMBL3939262 Ki 5.1 nM
COCCC#Cc1c(Cl)c2c(Cl)cc(C(N)=O)nc2n1[C@H]1CCCNC1 CHEMBL4540910 IC50 5.1 nM
CC(C)NC(=O)c1ccc(F)c(-c2ccc(N)c(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)n2)c1 CHEMBL3691981 IC50 5.15 nM
CC(C)Oc1cncc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3965218 IC50 5.177 nM
COC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3cc(C(=O)NC(C)C)ccc3F)ccc2N)C[C@@H]1C CHEMBL3691983 IC50 5.19 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Nc5c(F)cccc5Cl)nc34)cc21 CHEMBL3939032 IC50 5.2 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c3N=C(NC(C)(C)C)N(C)S4(=O)=O)[nH]c21 CHEMBL4546373 IC50 5.2 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1cc(C(C)(C)O)nn1 CHEMBL3691972 IC50 5.27 nM
CN(C)C(=O)c1ccc(F)c(-c2ccc3cnc(Nc4cnccc4N4CCC[C@H](N)C4)n3n2)c1 CHEMBL3916248 IC50 5.3 nM
CC1(C)CNCCN1c1cnc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3977800 IC50 5.3 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691952 IC50 5.31 nM
OCCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3980111 Ki 5.38 nM
c1cc(-c2n[nH]c3cnc(-n4ccnc4)cc23)nc(N2CCNCC2)c1 CHEMBL3634773 Ki 5.4 nM
C[C@H]1[C@@H](N)CCCN1c1ccncc1Nc1ncc2ccc(-c3c(F)cccc3F)nn12 CHEMBL3956489 IC50 5.4 nM
C[C@H]1[C@H](N)CCCN1c1ccncc1Nc1ncc2ccc(-c3c(F)cccc3F)nn12 CHEMBL3900795 IC50 5.4 nM
COCC(C)(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2nc1C CHEMBL3965003 IC50 5.4 nM
CC(C)Oc1cccc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3901441 IC50 5.458 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CCCC1 CHEMBL3925905 IC50 5.5 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(C3(O)CCCNC3)n2)n1 CHEMBL3974800 Ki 5.56 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(C)CCOCC1 CHEMBL3892409 IC50 5.6 nM
CNc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC(C)(C)C CHEMBL3893675 IC50 5.61 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1(C)COC1 CHEMBL3897814 IC50 5.7 nM
CC1(C#Cc2c(Cl)c3c(Cl)cc(C(N)=O)nc3n2[C@H]2CCCNC2)COC1 CHEMBL4470576 IC50 5.7 nM
Clc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3946306 Ki 5.74 nM
CCOCc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](S(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687526 IC50 5.78 nM
Cc1nc2cccc(-c3cc4c(=O)[nH]cnc4[nH]3)c2nc1NC(C)(C)CO CHEMBL3940464 IC50 5.8 nM
c1cc2[nH]cc(-c3cncc(C4CC4)n3)c2cc1-c1nnc(NC2COC2)o1 CHEMBL3982185 IC50 5.842 nM
CC(C)Nc1nc2c(-c3cc4c([nH]3)CCNC4=O)cccc2c(=O)n1-c1ccccc1 CHEMBL3892102 IC50 5.87 nM
O=C(Nc1c[nH]c2ncccc12)c1cnn2ccc(NC[C@H]3CCNC[C@@H]3F)nc12 CHEMBL2387478 Ki 5.9 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CNC1 CHEMBL3933668 IC50 5.9 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(NC5CCCC5)n4)c3c2)s1 CHEMBL3394164 IC50 5.923 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1S(C)(=O)=O CHEMBL3687530 IC50 5.93 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccoc4)cc32)c(=O)[nH]1 CHEMBL572784 Ki 6.0 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccc(OCCCN)cc4)cc32)c(=O)[nH]1 CHEMBL576388 Ki 6.0 nM
Clc1ccccc1Nc1nc2c(-c3nnc[nH]3)cccc2c2cnccc12 CHEMBL1915438 IC50 6.0 nM
Cc1ccccc1Nc1nc2c(-c3nnc[nH]3)cccc2c2cnccc12 CHEMBL1915443 IC50 6.0 nM
Fc1ccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3cnccc23)c(F)c1 CHEMBL1915638 IC50 6.0 nM
Clc1ccccc1Nc1nc2c(-c3nnc[nH]3)cccc2c2ccsc12 CHEMBL2017328 IC50 6.0 nM
Clc1cccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3sccc23)c1 CHEMBL2017339 IC50 6.0 nM
COc1ccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3sccc23)cc1 CHEMBL2017352 IC50 6.0 nM
Cc1cc2c(Nc3ccccc3F)nc3c(-c4nnc[nH]4)cccc3c2s1 CHEMBL2017361 IC50 6.0 nM
Nc1ccc(-c2ccncc2)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 CHEMBL3103862 Ki 6.0 nM
Nc1ccc(-c2ccccn2)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 CHEMBL3103860 Ki 6.0 nM
Fc1cccnc1-c1ccc2[nH]nc(-c3cncc(O[C@H]4CNCCC45CC5)n3)c2c1 CHEMBL3393710 IC50 6.0 nM
Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(NC4CCNCC4)n3)c2c1 CHEMBL3393697 IC50 6.0 nM
Fc1cnccc1-c1ccc2[nH]nc(-c3cncc(O[C@H]4CNCCC45CC5)n3)c2c1 CHEMBL3393712 IC50 6.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](O)[C@@H]1O CHEMBL3652011 IC50 6.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3cc(F)ccc3F)n2)C1 CHEMBL3651957 IC50 6.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2cccc(-c3cc(O)ccc3F)n2)C1 CHEMBL3651931 IC50 6.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3cc(O)ccc3F)ccc2F)C1 CHEMBL3651939 IC50 6.0 nM
CC1CC(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)=CC(O)C1 CHEMBL3651999 IC50 6.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676300 Ki 6.0 nM
CCN(c1ccccc1)c1ccc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3903003 IC50 6.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1C[C@@H](N2CCOCC2)C1 CHEMBL3918021 IC50 6.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCCNC3)c2n1 CHEMBL4084988 IC50 6.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCC(N)CC3)c2n1 CHEMBL4070441 IC50 6.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CC3)n(C3CCCNC3)c2n1 CHEMBL4100435 IC50 6.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(C3CC3)n([C@H]3CCCNC3)c2n1 CHEMBL4104355 IC50 6.0 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC[C@H](NCC(F)F)CC1 CHEMBL4455188 Ki 6.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3COCCO3)n([C@H]3CCCNC3)c2n1 CHEMBL4466764 IC50 6.0 nM
Cc1cn([C@@H](C)[C@]2(F)CCNC2)c2nc(C(N)=O)cc(Cl)c12 CHEMBL4778578 IC50 6.0 nM
Cc1cn([C@@H](C)[C@H]2CCNC[C@H]2F)c2nc(C(N)=O)cc(Cl)c12 CHEMBL4759685 IC50 6.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@H](C)NC4=O)c2nc1NCC(F)(F)F CHEMBL3965960 IC50 6.02 nM
COC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)C[C@@H]1C CHEMBL3691951 IC50 6.07 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N(C)C(C)C CHEMBL3891287 IC50 6.1 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NC1CCOC1 CHEMBL3979545 IC50 6.1 nM
CC(O)CC#Cc1c(Cl)c2c(Cl)cc(C(N)=O)nc2n1[C@H]1CCCNC1 CHEMBL4588948 IC50 6.1 nM
NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CNCCO3)n([C@H]3CCCNC3)c2n1 CHEMBL4583118 IC50 6.1 nM
Cn1cc(-c2cc3c(-c4cccc(O[C@@H]5CCCNC5)n4)n[nH]c3cn2)cn1 CHEMBL3634755 Ki 6.2 nM
CS(=O)(=O)CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3956440 Ki 6.2 nM
N[C@H]1C=C(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)CCC1 CHEMBL4115439 IC50 6.3 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NCC(C)(C)N CHEMBL3980532 IC50 6.3 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL1970903 pKi 6.31 nM
Nc1nnc(-c2ccc3[nH]cc(-c4nccc(Oc5ccccc5)n4)c3c2)o1 CHEMBL3951570 IC50 6.391 nM
N[C@H]1CCCN(c2ccncc2Nc2ncc3ccc(-c4ccccn4)nn23)C1 CHEMBL3937423 IC50 6.4 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(N5CCC(F)(F)C5)n4)c3c2)o1 CHEMBL3942435 IC50 6.435 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1C#N CHEMBL3687467 IC50 6.47 nM
N[C@H]1CCCN(c2ccccc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C1 CHEMBL3921064 IC50 6.5 nM
Cc1ccc(-n2ncc3cnc(-c4cnn(CC(F)(F)F)c4)cc32)nc1N1CCNC[C@H](O)C1 CHEMBL3942104 Ki 6.51 nM
CN1CCCC(Nc2ccnc(-c3c[nH]c4ccc(-c5nnc(N)o5)cc34)n2)C1 CHEMBL3900527 IC50 6.595 nM
COCCS(=O)(=O)[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687432 IC50 6.68 nM
FC(F)(F)Cn1cc(-c2cc3c(cn2)cnn3-c2cncc(N3CCCNCC3)n2)cn1 CHEMBL3900834 Ki 6.68 nM
NC(=O)c1cc(Cl)c2c(Cl)c(C#CCN3CCCC3=O)n([C@H]3CCCNC3)c2n1 CHEMBL4446498 IC50 6.7 nM
CN(c1ccccc1)c1ccc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3947727 IC50 6.8 nM
Cc1nc2cccc(-c3cc4c(s3)CNC4=O)c2nc1NC(C)(C)C CHEMBL4514782 IC50 6.8 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)/C1=N\O CHEMBL3687419 IC50 6.81 nM
CN1CCN(c2cccc(-c3c[nH]c4ccc(-c5nnc(N)o5)cc34)n2)CC1 CHEMBL3960298 IC50 6.871 nM
Cc1nc2cccc(-c3cc4n(c3)CCNC4=O)c2nc1NC1CC1 CHEMBL3927624 IC50 6.9 nM
Cc1cscc1-c1ccc2sc3c(=O)[nH]c(CN(C)C)nc3c2c1 CHEMBL584563 Ki 7.0 nM
Clc1cc(OCCN2CCOCC2)ccc1Nc1nc2c(-c3nnc[nH]3)cccc2c2cnccc12 CHEMBL1915448 IC50 7.0 nM
Fc1ccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3sccc23)cc1 CHEMBL2017347 IC50 7.0 nM
Nc1ccc(-c2ccccc2C(F)(F)F)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 CHEMBL3103865 Ki 7.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3CCC[C@H](N)C3)ccc2F)c1F CHEMBL3651916 IC50 7.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2cccc(-c3ccc(O)cc3F)n2)C1 CHEMBL3651933 IC50 7.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](O)[C@@H](C)C3)n2)c1F CHEMBL3651927 IC50 7.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)C[C@@H](C(F)(F)F)C3)n2)c1 CHEMBL3652002 IC50 7.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@@H]1O CHEMBL3652024 IC50 7.0 nM
CCCOc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3CC[C@H](O)[C@H](N)C3)c(N)cc2F)c1 CHEMBL3651963 IC50 7.0 nM
CSc1ncc2c(n1)-c1c(c(C(N)=O)cn1[C@H]1CC[C@@H](N)CC1)CC2 CHEMBL3703183 IC50 7.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2cccc(-c3ccccc3F)n2)C1 CHEMBL3651958 IC50 7.0 nM
CC(=O)O[C@H]1CC[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)C[C@H]1N CHEMBL3651995 IC50 7.0 nM
Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1C1=CC(N)CCC1 CHEMBL3652001 IC50 7.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2F)C1 CHEMBL3651965 IC50 7.0 nM
NCC[C@H]1CNC(=O)c2cc(-c3cccc(OC(F)(F)F)c3)c(-c3ccc(CN4CCOCC4)cc3)n21 CHEMBL3940702 IC50 7.0 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(NC5CC5)nc34)cc21 CHEMBL3923078 IC50 7.0 nM
Nc1nnc(-c2ccc3[nH]cc(-c4nccc(-c5ccccc5F)n4)c3c2)o1 CHEMBL3904737 IC50 7.002 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cnc(O)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3920503 Ki 7.11 nM
CC(C)c1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)c1 CHEMBL3947484 Ki 7.14 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC(O)C3)n2)c1 CHEMBL3976760 Ki 7.26 nM
Cc1nnc(-c2cccc(-c3cnn4ccc(NCCN)nc34)c2)o1 CHEMBL2442291 IC50 7.3 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCN[C@@H](C)C3)n2)cn1 CHEMBL3968206 Ki 7.36 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](S(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687522 IC50 7.37 nM
NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CCCO3)n([C@H]3CCCNC3)c2n1 CHEMBL4518492 IC50 7.4 nM
C[C@H]1NC(=O)c2cc(-c3nccc4c(=O)n(C)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL4530924 IC50 7.4 nM
COC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C)cc3F)n2)C[C@@H]1C CHEMBL3691964 IC50 7.47 nM
c1cc2[nH]cc(-c3cncc(C4CC4)n3)c2cc1-c1nnc(NC2CC2)o1 CHEMBL3892732 IC50 7.641 nM
CC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687433 IC50 7.66 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(N)nc(NC(C)(C)C)nc34)[nH]c21 CHEMBL3931685 IC50 7.66 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC4CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1S(C)(=O)=O CHEMBL3687517 IC50 7.69 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Nc5cccc(F)c5)nc34)cc21 CHEMBL3906206 IC50 7.7 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(NCC5CC5)n4)c3c2)s1 CHEMBL3925863 IC50 7.705 nM
Nc1nnc(-c2ccc3[nH]cc(-c4nccc(N5CCC[C@@H](O)C5)n4)c3c2)o1 CHEMBL4113485 IC50 7.727 nM
Cc1nc2cccc(-c3cc(C(N)=O)c(C4CC4)[nH]3)c2nc1NC(C)(C)C CHEMBL3915882 IC50 7.79 nM
O=C(Nc1c[nH]c2ncccc12)c1cnn2ccc(NCC3CCNCC3)nc12 CHEMBL2387470 Ki 7.8 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1CC(C)(C)C CHEMBL3975613 IC50 7.8 nM
Cc1nc2cccc(-c3cc4c(n3C)C(CO)NC4=O)c2nc1NC(C)(C)C CHEMBL3912000 IC50 7.8 nM
CC(C)n1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3929264 Ki 7.81 nM
Cc1cncc(-c2ccc3cnn(-c4cccc(N5CCCNCC5)n4)c3c2)n1 CHEMBL4097308 Ki 7.9 nM
CS[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687445 IC50 7.94 nM
Cc1nc2cccc(-c3cc4c([nH]3)[C@H](COCc3ccccc3)NC4=O)c2nc1NC(C)(C)C CHEMBL3899420 IC50 7.94 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccccc4)cc32)c(=O)[nH]1 CHEMBL583273 Ki 8.0 nM
c1cc(-c2nnc[nH]2)c2nc(NC3CC3)c3ccncc3c2c1 CHEMBL1915428 IC50 8.0 nM
Cc1cc(F)ccc1Nc1nc2c(-c3nnc[nH]3)cccc2c2cnccc12 CHEMBL1915634 IC50 8.0 nM
Cc1ccc(F)cc1Nc1nc2c(-c3nnc[nH]3)cccc2c2cnccc12 CHEMBL1915635 IC50 8.0 nM
NC(=O)c1cccc2c1nc(Nc1ccccc1Cl)c1ccncc12 CHEMBL1915643 IC50 8.0 nM
Clc1ccccc1Nc1nc2c(-c3nnc[nH]3)cccc2c2cscc12 CHEMBL2017326 IC50 8.0 nM
COc1ccccc1-c1ccc(N)c(C(=O)Nc2cnccc2N2CCC[C@H](N)C2)n1 CHEMBL3103864 Ki 8.0 nM
c1csc(-c2ccc3[nH]nc(-c4cncc(O[C@H]5CNCCC56CC6)n4)c3c2)n1 CHEMBL3393715 IC50 8.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3ccc(O)cc3F)n2)C1 CHEMBL3651905 IC50 8.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3ccccc3F)n2)C[C@@H](N)[C@H]1O CHEMBL3651971 IC50 8.0 nM
C[C@@H]1CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)C[C@@H](N)[C@H]1O CHEMBL3651997 IC50 8.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](O)[C@@H](C)C3)ccc2F)c1 CHEMBL3651969 IC50 8.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)C[C@H](N)C3)n2)c1 CHEMBL3651954 IC50 8.0 nM
Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1C1=C[C@@H](N)[C@@H](O)CC1 CHEMBL3651988 IC50 8.0 nM
CCCOc1ccc(F)c(-c2ccc(N)c(C(=O)Nc3cnccc3[C@@H]3CC[C@H](O)[C@H](N)C3)n2)c1 CHEMBL3651964 IC50 8.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2cccc(-c3cc(O)ccc3F)n2)C1 CHEMBL3651903 IC50 8.0 nM
Nc1cc(-c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)ccn1 CHEMBL3793927 Ki 8.0 nM
CC1CCN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)CC1N CHEMBL3676275 IC50 8.0 nM
O[C@H]1CCN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C[C@@H]1O CHEMBL3892307 IC50 8.0 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Nc5ccccc5)nc34)cc21 CHEMBL3942833 IC50 8.0 nM
COc1ncc2cc1NS(=O)(=O)c1ccc(F)c(c1)C(=O)NCc1ccc(s1)-c1ncnc3c(C)c-2sc13 CHEMBL4878958 IC50 8.04 nM
O[C@H]1CCC[C@@H]1Nc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3983795 Ki 8.05 nM
C=C(c1ccccc1)c1ccc2cccc(-c3cc4c([nH]3)CCNC4=O)c2n1 CHEMBL3964505 IC50 8.1 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cccc3F)n2)c1N1CCC[C@H](N)CC1 CHEMBL4449080 Ki 8.1 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCCNC4=O)c2nc1NC(C)(C)C CHEMBL3907325 IC50 8.1 nM
NC1CN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)C1 CHEMBL3943778 Ki 8.18 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1N[C@H]1C[C@H](NC(=O)OC(C)(C)C)C1 CHEMBL3891457 IC50 8.2 nM
CNc1nnc(-c2ccc3[nH]cc(-c4cccc(-n5cnc(C)c5)n4)c3c2)s1 CHEMBL3957552 IC50 8.279 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(C3=CCNCC3)n2)n1 CHEMBL3973175 Ki 8.31 nM
NC(=O)Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3940227 Ki 8.33 nM
Cc1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)sn1 CHEMBL3915323 Ki 8.49 nM
Cc1nc2cccc(-c3cc4c(n3C)CCNC4=O)c2nc1NC(C)(C)C CHEMBL3984361 IC50 8.58 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Oc5c(F)cccc5Cl)nc34)cc21 CHEMBL3944428 IC50 8.6 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(C3(F)CCCNCC3)n2)cn1 CHEMBL3975787 Ki 8.6 nM
Nc1nnc(-c2ccc3[nH]cc(-c4nccc(N5CCOCC5)n4)c3c2)s1 CHEMBL3899208 IC50 8.613 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NCC(C)(C)O CHEMBL3925309 IC50 8.7 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(C3CNCCC3O)n2)n1 CHEMBL3895094 Ki 8.79 nM
O[C@@H]1CCN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C[C@H]1O CHEMBL4109810 IC50 8.8 nM
CC(C)(C)Nc1nnc(-c2ccc3[nH]cc(-c4ncc(F)c(C5CC5)n4)c3c2)o1 CHEMBL3978285 IC50 8.813 nM
COC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC(C)C)cc3F)n2)C[C@@H]1C CHEMBL3691933 IC50 8.88 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(C5(c6ccccc6)CC5)nc34)cc21 CHEMBL3966443 IC50 8.9 nM
COC1=NCCc2[nH]c(-c3cccc4nc(C)c(NC(C)(C)C)nc34)cc21 CHEMBL3916951 IC50 8.9 nM
Cc1nc2cccc(-c3cc(C(N)=O)n[nH]3)c2nc1NC(C)(C)C CHEMBL3927458 IC50 8.9 nM
Clc1ccccc1Nc1nc2c(-c3nnc[nH]3)cccc2c2scnc12 CHEMBL2017329 IC50 9.0 nM
Fc1ccc(Nc2nc3c(-c4nnc[nH]4)cccc3c3sccc23)c(Cl)c1 CHEMBL2017342 IC50 9.0 nM
NC1CCN(c2cncc(-c3n[nH]c4ccc(-c5c(F)cccc5F)cc34)n2)CC1 CHEMBL3393692 IC50 9.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3cc(O)ccc3F)n2)C1 CHEMBL3651929 IC50 9.0 nM
Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1C1=CC(N)C(O)CC1 CHEMBL3651987 IC50 9.0 nM
C[C@@H]1C[C@H](N)CN(c2ccncc2Nc2cccc3cnc(-c4c(F)cccc4F)nc23)C1 CHEMBL3685747 IC50 9.0 nM
CCOc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)C[C@H](N)C3)cs2)c1F CHEMBL3676307 IC50 9.0 nM
CN(C)Cc1ccc(-c2c(-c3cccc(OC(F)(F)F)c3)cc3n2[C@@H](CCN)CNC3=O)cc1 CHEMBL3935180 IC50 9.0 nM
Cc1cc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1Oc1ccccc1 CHEMBL3913032 IC50 9.0 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCN(CO)C4=O)c2nc1NC(C)(C)C CHEMBL3894660 IC50 9.0 nM
NCC1CCC(n2c(I)c(Cl)c3c(Cl)cc(C(N)=O)nc32)CC1 CHEMBL4087517 IC50 9.0 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC[C@H](NCC(F)(F)F)CC1 CHEMBL4449930 Ki 9.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(C#CC3CC3)n([C@H]3CCCNC3)c2n1 CHEMBL4564586 IC50 9.0 nM
c1cc(N2CCCNCC2)nc(-n2ncc3cnc(-c4cncc(C5COC5)c4)cc32)c1 CHEMBL3939101 Ki 9.04 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](S(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687528 IC50 9.07 nM
CS(=O)(=O)c1ccc(-c2ccc3cnc(Nc4cnccc4N4CCC[C@H](N)C4)n3n2)c(F)c1 CHEMBL3957474 IC50 9.1 nM
O=C1NCCc2[nH]c(-c3cccc4ccc(Oc5cccc(F)c5)nc34)cc21 CHEMBL3950494 IC50 9.1 nM
c1cc(N2CCNCC2)nc(-n2ncc3cnc(-c4cncc(C5CC5)c4)cc32)c1 CHEMBL3980040 Ki 9.11 nM
CC(O)C#Cc1c(Cl)c2c(Cl)cc(C(N)=O)nc2n1[C@H]1CCCNC1 CHEMBL4593810 IC50 9.3 nM
N[C@@H]1C=C(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)CCC1 CHEMBL3940201 IC50 9.4 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1N=[N+]=[N-] CHEMBL3687440 IC50 9.44 nM
FC(F)n1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3981104 Ki 9.54 nM
CC(C)c1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@@H](N)C3)n2)c1 CHEMBL4110326 Ki 9.58 nM
Cc1nc2cccc(-c3cc4c([nH]3)CCNC4=O)c2nc1NS(C)(=O)=O CHEMBL3902617 IC50 9.6 nM
Cc1cncc(-c2cc3c(ccn3-c3cccc(N4CCCNCC4)n3)cn2)n1 CHEMBL4070117 Ki 9.6 nM
OC1CN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)C1 CHEMBL3906850 Ki 9.62 nM
CC(C)Nc1cncc(-c2c[nH]c3ccc(-c4nnc(N)s4)cc23)n1 CHEMBL3394074 IC50 9.654 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N(C)C)n2)n1 CHEMBL3984232 Ki 9.69 nM
C[C@H]1CCCCN1c1cccc(-c2c[nH]c3ccc(-c4nnc(N)s4)cc23)n1 CHEMBL3900171 IC50 9.735 nM
N[C@H]1CCCN(c2ccncc2NC(=O)c2csc(-c3ccccc3F)n2)C1 CHEMBL3676303 IC50 9.9 nM
CC(C)(O)C#Cc1c(Cl)c2c(Cl)cc(C(N)=O)nc2n1[C@H]1CCCNC1 CHEMBL4587382 IC50 9.9 nM