C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3105022 Ki 0.001 nM
C[C@H]1CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@@H]1O CHEMBL3105021 Ki 0.003 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC[C@H](NCC(F)F)CC1 CHEMBL4455188 Ki 0.005 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1[C@@]12CC[C@@H](N)[C@@H](CC1)O2 CHEMBL4109141 Ki 0.005 nM
Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 CHEMBL3103868 Ki 0.006 nM
Cc1ccc(-c2n[nH]c3cnc(-c4cnn(C)c4)cc23)nc1N1CCC[C@H](N)C1 CHEMBL3634760 Ki 0.006 nM
Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1N1CC[C@@H](O)[C@H](N)C1 CHEMBL3103869 Ki 0.007 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC[C@H](N)CC1 CHEMBL4437940 Ki 0.007 nM
COc1ccc(-n2ncc3cnc(-c4cncc(C)n4)cc32)nc1N1CCC[C@H](N)C1 CHEMBL3914639 Ki 0.008 nM
O=C(Nc1c[nH]c2ncc(-c3ccccc3F)cc12)c1cnn2ccc(NC[C@H]3CCNC[C@@H]3F)nc12 CHEMBL2387464 Ki 0.009 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C1 CHEMBL3651966 Ki 0.009 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C(F)(F)F)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3961823 Ki 0.009 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCCC(N)C(F)C1 CHEMBL3648675 Ki 0.009 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@@H](N)CC(F)(F)C1 CHEMBL3623150 Ki 0.009 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccccc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C1 CHEMBL4741714 IC50 0.009 nM
c1cncc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)c1 CHEMBL3634781 Ki 0.01 nM
Cc1cncc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)n1 CHEMBL3634783 Ki 0.01 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC[C@@H](N)CC1 CHEMBL3652638 Ki 0.01 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@@](C)(N)CC(F)(F)C1 CHEMBL3623162 Ki 0.01 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@@H](N)[C@@H](O)CC1 CHEMBL4453890 Ki 0.01 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC(N)CC(F)C1 CHEMBL4439756 Ki 0.01 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1CCC(N)C(F)CC1 CHEMBL4469964 Ki 0.01 nM
Cc1nc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](N)C3)n2)cnc1N CHEMBL3906798 Ki 0.011 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(F)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3953164 Ki 0.011 nM
N#CCn1cc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3634771 Ki 0.013 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3634767 Ki 0.013 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](N)C3)n2)n1 CHEMBL3896312 Ki 0.014 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3982539 Ki 0.014 nM
Cc1nc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cnc1N CHEMBL3959091 Ki 0.014 nM
Cn1cc(-c2cc3c(-c4cccc(N5CC[C@@H](N)C5)n4)n[nH]c3cn2)cn1 CHEMBL3634757 Ki 0.015 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCC[C@H](N)C5)n4)n[nH]c3cn2)cn1 CHEMBL3634758 Ki 0.015 nM
c1cc(-c2n[nH]c3cnc(-c4cnn(CC5CC5)c4)cc23)nc(N2CCNCC2)c1 CHEMBL3634772 Ki 0.016 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CC(N)CCC3C)n2)n1 CHEMBL3976267 Ki 0.016 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3634770 Ki 0.017 nM
OCCCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3910536 Ki 0.018 nM
O=C(Nc1c[nH]c2ncc(-c3c(F)cccc3F)cc12)c1cnn2ccc(NC[C@H]3CCNC[C@@H]3F)nc12 CHEMBL2387465 Ki 0.019 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)n1 CHEMBL3943705 Ki 0.019 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C3CC3)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3932475 Ki 0.019 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C(F)F)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3940744 Ki 0.019 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)n1 CHEMBL3960554 Ki 0.0199 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C#N)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3898989 Ki 0.02 nM
N[C@H]1CCCN(c2cccc(-c3n[nH]c4cnc(-c5cccnc5)cc34)n2)C1 CHEMBL3956349 Ki 0.02 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc([C@H]3CNCCC3(F)F)n2)n1 CHEMBL4076913 Ki 0.02 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 CHEMBL3676285 Ki 0.02 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCC[C@H](NCC(F)(F)F)CC1 CHEMBL4449930 Ki 0.02 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@@H](N)[C@H](F)CC1 CHEMBL3648680 Ki 0.02 nM
CO[C@H]1C[C@H](N)CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)C1 CHEMBL4459538 Ki 0.02 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCC[C@@H](N)C5)n4)n[nH]c3cn2)cn1 CHEMBL3634756 Ki 0.021 nM
OCCNc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3946464 Ki 0.021 nM
O=C(Nc1c[nH]c2ncc(-c3ccccc3F)cc12)c1cnn2ccc(NCC3CCNCC3)nc12 CHEMBL2387463 Ki 0.022 nM
O=C(Nc1c[nH]c2ncccc12)c1cnn2ccc(NC[C@@H]3CCNC[C@H]3F)nc12 CHEMBL2387479 Ki 0.022 nM
O=C(Nc1c[nH]c2ncc(-c3c(F)cccc3F)cc12)c1cnn2ccc(NCC3CCNCC3)nc12 CHEMBL2387471 Ki 0.022 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCCC(N)CC1 CHEMBL3652626 Ki 0.022 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNC(C)C3)n2)n1 CHEMBL3937096 Ki 0.022 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(NC3CCNCC3)n2)n1 CHEMBL3900258 Ki 0.023 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(C3CNCCC3(F)F)n2)n1 CHEMBL3926007 Ki 0.0235 nM
O=C(Nc1c[nH]c2ncc(-c3c(F)cccc3F)cc12)c1cnn2ccc(CCC3CCNCC3)nc12 CHEMBL2387474 Ki 0.025 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCC(N)C3C)n2)n1 CHEMBL3927952 Ki 0.025 nM
c1cc(N2CCNCC2)nc(-n2ncc3cnc(-c4cncc(N5CCC5)n4)cc32)c1 CHEMBL3951741 Ki 0.025 nM
Nc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)n1 CHEMBL3961692 Ki 0.026 nM
CC#Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3983351 Ki 0.026 nM
C[C@@H]1C[C@H](N)CN(c2ccncc2Nc2ncc3ccc(-c4c(F)cccc4F)nn23)C1 CHEMBL3942186 IC50 0.027 nM
Cc1cncc(-c2cc3c(cnn3-c3cccc(N4CCCNCC4)n3)nn2)n1 CHEMBL4091687 Ki 0.03 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC(O)C3)n2)cn1 CHEMBL3937034 Ki 0.032 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cnc(C3CC3)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3920778 Ki 0.032 nM
OCC#Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3934383 Ki 0.032 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNC[C@H]3C)n2)n1 CHEMBL4112816 Ki 0.033 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C3CC3)c(N3CCC[C@H](N)C3)n2)c1 CHEMBL3930816 Ki 0.035 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(C3CCCC(N)C3)n2)n1 CHEMBL3929011 Ki 0.035 nM
O=C(Nc1c[nH]c2ncccc12)c1cnn2ccc(NCC3(F)CCNCC3)nc12 CHEMBL2387462 Ki 0.036 nM
OCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3919520 Ki 0.036 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(OC3CCCC(N)C3)n2)n1 CHEMBL3924903 Ki 0.036 nM
Cc1cncc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)c1 CHEMBL3634782 Ki 0.037 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](N)C3)n2)n1 CHEMBL3935096 Ki 0.038 nM
Cc1cncc(-c2cc3c(-c4cccc(N5CCCNCC5)n4)n[nH]c3cn2)n1 CHEMBL3978766 Ki 0.04 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3634761 Ki 0.041 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C3CC3)c(N3CCCNCC3)n2)n1 CHEMBL3922549 Ki 0.046 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(Cl)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3891851 Ki 0.047 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cnc(C)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3935018 Ki 0.047 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3946970 Ki 0.048 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC(O)C3)n2)n1 CHEMBL3905519 Ki 0.048 nM
CC(C)c1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](N)C3)n2)c1 CHEMBL3952845 Ki 0.049 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3944062 Ki 0.0498 nM
c1cc(N2CCNCC2)nc(-n2ncc3cnc(-c4cnccn4)cc32)c1 CHEMBL3902417 Ki 0.05 nM
Cc1cncc(-c2cc3c(cnn3-c3cccc(N4CCNCC4)n3)nn2)n1 CHEMBL3970953 Ki 0.05 nM
O=C(Nc1c[nH]c2ncccc12)c1cnn2ccc(NCC3CCNCC3)nc12 CHEMBL2387470 Ki 0.053 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(CO)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3892885 Ki 0.054 nM
CS(=O)(=O)CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3956440 Ki 0.055 nM
C#Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3890953 Ki 0.057 nM
Nc1ccc(-c2ccccc2F)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 CHEMBL3103867 Ki 0.06 nM
O=C(Nc1c[nH]c2ncccc12)c1cnn2ccc(NC[C@H]3CCNC[C@@H]3F)nc12 CHEMBL2387478 Ki 0.061 nM
O=C(Nc1c[nH]c2ncc(-c3c(F)cccc3F)cc12)c1cnn2ccc(OCC3CCNCC3)nc12 CHEMBL2387475 Ki 0.062 nM
OC1CN(c2cncc(-c3cc4c(cn3)cnn4-c3cccc(N4CCNCC4)n3)n2)C1 CHEMBL3975756 Ki 0.064 nM
CC(C)c1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)c1 CHEMBL3975764 Ki 0.065 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCCC(N)C3)n2)n1 CHEMBL3937209 Ki 0.067 nM
COc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3917077 Ki 0.068 nM
CCn1cncc(-c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)c1=O CHEMBL3634769 Ki 0.07 nM
N[C@H]1CCC[C@@H]1Oc1cncc(-c2cc3c(cn2)cnn3-c2ccccn2)n1 CHEMBL3963170 Ki 0.07 nM
COc1ncc(-n2ncc3cnc(-c4cncc(C)n4)cc32)nc1N1CCC[C@H](N)C1 CHEMBL3897912 Ki 0.073 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNC[C@@H]3C)n2)n1 CHEMBL3949274 Ki 0.074 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNC(C)CC3)n2)n1 CHEMBL3895531 Ki 0.076 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)c1 CHEMBL3901481 Ki 0.077 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)c1 CHEMBL3939394 Ki 0.078 nM
c1cc(N2CCCNCC2)nc(-n2ncc3cnc(-c4cnn(C5CC5)c4)cc32)c1 CHEMBL3984183 Ki 0.079 nM
CCn1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)c1=O CHEMBL3947770 Ki 0.081 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNC[C@@H](O)C3)n2)c1 CHEMBL4111637 Ki 0.083 nM
FCCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3942446 Ki 0.085 nM
c1cc(N2CCCNCC2)nc(-n2ncc3cnc(-c4cn[nH]c4)cc32)c1 CHEMBL3968789 Ki 0.086 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.0885 nM
O[C@H]1CNCCN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)C1 CHEMBL3909280 Ki 0.089 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3C[C@@H](N)C[C@@H](F)C3)n2)n1 CHEMBL4113302 Ki 0.089 nM
CCNc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3891387 Ki 0.09 nM
NCCOc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3960453 Ki 0.092 nM
c1cc(N2CCCNCC2)nc(-n2ncc3cnc(-c4cncc(C5CC5)c4)cc32)c1 CHEMBL3951088 Ki 0.093 nM
COc1ccc(-n2ncc3cnc(-c4cncc(C)n4)cc32)nc1N1CCNCC(O)C1 CHEMBL3893598 Ki 0.093 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC4(CCCN4)CC3)n2)n1 CHEMBL3981915 Ki 0.094 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3892509 Ki 0.097 nM
O=C(Nc1c[nH]c2ccc(-c3c(F)cccc3F)nc12)c1cnn2ccc(NCC3CCNCC3)nc12 CHEMBL2387473 Ki 0.098 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2ccc(Cl)c(N3CCC[C@H](N)C3)n2)c1 CHEMBL3908350 Ki 0.098 nM
C=Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3947309 Ki 0.098 nM
N[C@H]1CCC[C@@H]1Nc1cncc(-c2cc3c(cn2)cnn3-c2ccccn2)n1 CHEMBL3915913 Ki 0.098 nM
NC1CCN(c2cncc(-c3cc4c(-c5ccccc5F)n[nH]c4cn3)n2)CC1 CHEMBL3634779 Ki 0.1 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCN(C)CC5)n4)n[nH]c3cn2)cn1 CHEMBL3956461 Ki 0.1 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@@H](N)C(F)(F)CC1 CHEMBL4450356 Ki 0.1 nM
OC[C@@H]1CCCN1c1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3907493 Ki 0.101 nM
OCCOc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3961360 Ki 0.105 nM
N#CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3970981 Ki 0.109 nM
Fc1ccccc1-c1n[nH]c2cnc(-c3cnccc3O[C@@H]3CCCNC3)cc12 CHEMBL3634777 Ki 0.11 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCC4(CNC4)C3)n2)n1 CHEMBL3983224 Ki 0.112 nM
c1cc(N2CCCNCC2)nc(-n2ncc3cnc(-c4cncc(C5COC5)c4)cc32)c1 CHEMBL3939101 Ki 0.117 nM
Cn1cc(-c2cc3c(-c4cccc(C5CCNCC5)n4)n[nH]c3cn2)cn1 CHEMBL3634768 Ki 0.12 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC(N)CC3)n2)n1 CHEMBL3966696 Ki 0.125 nM
FC1CCNCC1c1cccc(-n2ncc3cnc(-c4cnn(CC(F)(F)F)c4)cc32)n1 CHEMBL3900425 Ki 0.125 nM
Cc1ccc(-n2ncc3cnc(-c4cnn(CC(F)(F)F)c4)cc32)nc1N1CCNC[C@@H](O)C1 CHEMBL4109699 Ki 0.127 nM
FC(F)c1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3957997 Ki 0.132 nM
OCCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3980111 Ki 0.134 nM
O=C(Nc1c[nH]c2ccc(-c3c(F)cccc3F)cc12)c1cnn2ccc(NCC3CCNCC3)nc12 CHEMBL2387472 Ki 0.14 nM
Cc1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](N)C3)n2)sn1 CHEMBL3973544 Ki 0.14 nM
OCC(O)c1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3933868 Ki 0.142 nM
COC1(c2cccc(-n3ncc4cnc(-c5cncc(C)n5)cc43)n2)CCCNC1 CHEMBL3955604 Ki 0.144 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](N)C3)n2)cn1 CHEMBL3963946 Ki 0.155 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)ccc2N)c1N1CCCC(N)CC1 CHEMBL3652627 Ki 0.159 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC(O)C3)n2)c1 CHEMBL3976760 Ki 0.159 nM
Cn1cc(-c2cc3c(-c4cccc(O[C@@H]5CCCNC5)n4)n[nH]c3cn2)cn1 CHEMBL3634755 Ki 0.16 nM
Cc1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)sn1 CHEMBL3985111 Ki 0.168 nM
c1cc(N2CCNCC2)nc(-n2ncc3cnc(-c4cncc(C5CC5)n4)cc32)c1 CHEMBL3958785 Ki 0.174 nM
FC(F)(F)Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3972050 Ki 0.175 nM
CN[C@H]1CCCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC1 CHEMBL3652645 Ki 0.176 nM
c1cc(N2CCNCC2)nc(-n2ncc3cnc(-c4cncc(C5CC5)c4)cc32)c1 CHEMBL3980040 Ki 0.181 nM
O[C@H]1CCC[C@@H]1Nc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3983795 Ki 0.182 nM
CC(C)c1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)c1 CHEMBL3947484 Ki 0.183 nM
NC(=O)Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3940227 Ki 0.185 nM
C[C@H]1CN(c2cccc(-n3ncc4cnc(-c5cncc(C6COC6)c5)cc43)n2)CCN1 CHEMBL3890745 Ki 0.186 nM
O=C(Nc1c[nH]c2ncccc12)c1cnn2ccc(NCCc3ccccc3)nc12 CHEMBL2387469 Ki 0.19 nM
CO[C@@H]1CCN(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC[C@H]1N CHEMBL3648724 Ki 0.19 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC4(CNC4)C3)n2)n1 CHEMBL3907320 Ki 0.199 nM
CN(C)Cc1nc2c(sc3ccc(/C=C/C4CC4)cc32)c(=O)[nH]1 CHEMBL576387 Ki 0.2 nM
NCCNc1cccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)n1 CHEMBL3634780 Ki 0.2 nM
Cc1cncc(-c2ccc3cnn(-c4cccc(N5CCCNCC5)n4)c3c2)n1 CHEMBL4097308 Ki 0.2 nM
CCn1cc(-c2cc3c(-c4cccc(N5CCOCC5)n4)n[nH]c3cn2)cn1 CHEMBL3915064 Ki 0.2 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCCNCC1 CHEMBL4458081 Ki 0.2 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CCCC(O)CC1 CHEMBL4472966 Ki 0.2 nM
CC(C)c1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@@H](N)C3)n2)c1 CHEMBL4110326 Ki 0.203 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(C3CNCCC3O)n2)n1 CHEMBL3895094 Ki 0.206 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(C3(F)CCCNC3)n2)n1 CHEMBL3909947 Ki 0.209 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3C[C@@H](N)C[C@H](F)C3)n2)n1 CHEMBL3975198 Ki 0.21 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H](N)[C@H]1OCCC#N CHEMBL3687474 IC50 0.22 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3907004 Ki 0.226 nM
N[C@@H]1CCCN(c2c(/C=C3\SC(=O)NC3=O)cccc2-c2ccccc2)C1 CHEMBL2048872 Ki 0.23 nM
CNc1cccc(-n2ncc3cnc(-c4cncc(C)n4)cc32)n1 CHEMBL3931274 Ki 0.235 nM
COc1ccc(-n2ncc3cnc(-c4cnn(CC(F)(F)F)c4)cc32)nc1N1CCNC[C@@H](O)C1 CHEMBL4115539 Ki 0.236 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)ccc2N)c1N1CCC[C@H](N)CC1 CHEMBL3652640 Ki 0.245 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](O)C3)n2)n1 CHEMBL3906421 Ki 0.248 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CC4(CCNC4)C3)n2)n1 CHEMBL3958435 Ki 0.258 nM
c1cc(N2CCCNCC2)nc(-n2ncc3cnc(-c4cnn(C5CCC5)c4)cc32)c1 CHEMBL3944757 Ki 0.259 nM
O=C(Nc1c[nH]c2ncccc12)c1cnn2ccc(NC[C@@H]3CCNC[C@@H]3F)nc12 CHEMBL2387476 Ki 0.26 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H](N)[C@H]1OCCS(C)(=O)=O CHEMBL3691919 IC50 0.26 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C(F)(F)F)c(N3CCNCC(O)C3)n2)n1 CHEMBL3934315 Ki 0.265 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@H](N)C3=O)n2)n1 CHEMBL3952360 Ki 0.267 nM
Clc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3946306 Ki 0.267 nM
c1cc(N2CCNCC2)nc(-n2ncc3cnc(-c4cncs4)cc32)c1 CHEMBL3953990 Ki 0.285 nM
Cn1cc(-c2cc3c(-c4cccc(N5CCC[C@@H](N)C5)c4)n[nH]c3cn2)cn1 CHEMBL3634759 Ki 0.29 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)cn1 CHEMBL3892536 Ki 0.291 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)cnc2N)c1N1CCC[C@@H](N)CC1 CHEMBL3652639 Ki 0.295 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccccc4)cc32)c(=O)[nH]1 CHEMBL583273 Ki 0.3 nM
O=c1[nH]c(CN2CC[C@H](O)C2)nc2c1sc1ccc(-c3ccccc3)cc12 CHEMBL572781 Ki 0.3 nM
O=C(Nc1c[nH]c2ncccc12)c1cnn2ccc(NC[C@H]3CCNC[C@H]3F)nc12 CHEMBL2387477 Ki 0.3 nM
CCc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNC[C@H](O)C3)n2)c1 CHEMBL3956155 Ki 0.301 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)cnc2N)c1N1CCC[C@H](N)C1 CHEMBL3652630 Ki 0.305 nM
OC1CNCCN(c2cccc(-n3ncc4cnc(-c5cncc(C6CC6)c5)cc43)n2)C1 CHEMBL3936808 Ki 0.306 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cccc(N5CCCC[C@@H]5N)n4)c3c2)s1 CHEMBL4108864 IC50 0.307 nM
Cc1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)sn1 CHEMBL3915323 Ki 0.307 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H]1C CHEMBL3687492 IC50 0.32 nM
c1ccc(COc2cncc(-c3cc4c(cn3)cnn4-c3cccc(N4CCNCC4)n3)n2)cc1 CHEMBL3972453 Ki 0.337 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)ccc2N)c1N1CCC[C@@H](N)C1 CHEMBL3652625 Ki 0.34 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CC[C@H](N)C3)n2)n1 CHEMBL3943759 Ki 0.34 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1N1CC[C@H](CN)C1 CHEMBL3652637 Ki 0.344 nM
c1cc2[nH]cc(-c3cncc(C4CC4)n3)c2cc1-c1nnc(NC2CNC2)o1 CHEMBL3905618 IC50 0.346 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCN[C@@H](C)C3)n2)cn1 CHEMBL3968206 Ki 0.349 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@H]1OCCC#N CHEMBL3691950 IC50 0.36 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CC(O)(CN)C3)n2)cn1 CHEMBL3959634 Ki 0.361 nM
N#Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3975199 Ki 0.363 nM
N[C@@H]1CCCN(c2cccc(-n3ncc4cnc(-c5cncs5)cc43)n2)C1 CHEMBL4106584 Ki 0.37 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(C3(F)CCCNCC3)n2)cn1 CHEMBL3975787 Ki 0.37 nM
O=c1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)[nH]1 CHEMBL3900423 Ki 0.37 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNC(C)(C)C3)n2)cn1 CHEMBL3938583 Ki 0.385 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@H]1OCCS(C)(=O)=O CHEMBL3691930 IC50 0.39 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@@H](O)C3)n2)n1 CHEMBL4107092 Ki 0.396 nM
O=c1[nH]c(CN2CC[C@H](O)C2)nc2c1sc1ccc(-c3ccc(O)cc3)cc12 CHEMBL583187 Ki 0.4 nM
Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(O[C@H]4CNCCC45CC5)n3)c2c1 CHEMBL3393706 IC50 0.4 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H]1C CHEMBL3687479 IC50 0.4 nM
c1ccc(-n2ncc3cnc(-c4cncc(NC5CNC5)n4)cc32)nc1 CHEMBL3985665 Ki 0.4 nM
COc1ccc2c(c1CN1CCNCC1)O/C(=C\c1c[nH]c3nc(Cl)ccc13)C2=O CHEMBL4062256 IC50 0.4 nM
Cc1cncc(-c2cnc3cnn(-c4cccc(N5CCCNCC5)n4)c3c2)n1 CHEMBL4089586 Ki 0.4 nM
Cc1cncc(-c2cn3c(-c4cccc(N5CCCNCC5)n4)ncc3cn2)n1 CHEMBL4061456 Ki 0.4 nM
Cn1ncc(NC(=O)c2csc(-c3c(F)cccc3F)n2)c1N1CCC[C@H](N)CC1 CHEMBL4449080 Ki 0.4 nM
C[C@]12O[C@H](C[C@H](O)[C@H]1O)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4=O CHEMBL4444272 Kd 0.4 nM
OC1CNCCN(c2cccc(-n3ncc4cnc(-c5cncc(C6COC6)c5)cc43)n2)C1 CHEMBL3908853 Ki 0.405 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H]1C CHEMBL3691958 IC50 0.41 nM
Cc1cn(-c2cccc(-c3c[nH]c4ccc(-c5nnc(N)s5)cc34)n2)cn1 CHEMBL3901582 IC50 0.425 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H]1C CHEMBL3687482 IC50 0.43 nM
CC(C)Nc1nnc(-c2ccc3[nH]cc(-c4nccc(C5CC5)n4)c3c2)o1 CHEMBL3919337 IC50 0.435 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(C3CCNCC3)n2)n1 CHEMBL3931279 Ki 0.447 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC4(CCNC4)CC3)n2)n1 CHEMBL3982105 Ki 0.451 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCC(N)CC3)n2)cn1 CHEMBL3958302 Ki 0.454 nM
CC[C@@H]1CN(c2cccc(-n3ncc4cnc(-c5cnn(CC)c5)cc43)n2)CCN1 CHEMBL4110363 Ki 0.458 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC[C@@H](N)C3)n2)cn1 CHEMBL4115315 Ki 0.473 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC(O)C(O)C3)n2)n1 CHEMBL3965243 Ki 0.481 nM
COC(=O)N(C)[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687471 IC50 0.49 nM
COC(=O)N(C)[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C)cc3F)n2)C[C@@H]1C CHEMBL3687468 IC50 0.49 nM
CC(C)Nc1nnc(-c2ccc3[nH]cc(-c4cncc(C5CC5)n4)c3c2)o1 CHEMBL3932201 IC50 0.498 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccc(O)cc4)cc32)c(=O)[nH]1 CHEMBL585182 Ki 0.5 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CC(N)C3)n2)cn1 CHEMBL3919378 Ki 0.507 nM
Cc1ccc(-n2ncc3cnc(-c4cnn(CC(F)(F)F)c4)cc32)nc1N1CCNC[C@H](O)C1 CHEMBL3942104 Ki 0.536 nM
CCO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H]1C CHEMBL3687481 IC50 0.54 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC(C)C)cc3F)n2)C[C@@H]1C CHEMBL3691932 IC50 0.55 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N(C)C)n2)n1 CHEMBL3984232 Ki 0.562 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(C3(O)CCCNC3)n2)n1 CHEMBL3974800 Ki 0.564 nM
CN[C@H]1CC2OC([C@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(O)=NC4 CHEMBL3975634 IC50 0.57 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)sc2N)c1N1CCC[C@H](N)C1 CHEMBL3652623 Ki 0.575 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(NC5CCCC5)n4)c3c2)o1 CHEMBL3917311 IC50 0.586 nM
COc1ccc(-n2ncc3cnc(-c4cnn(CC(F)(F)F)c4)cc32)nc1N1CCNCC(O)C1 CHEMBL3981028 Ki 0.587 nM
N#Cc1ccc(Cc2cc(O)n3ncc(C(=O)Nc4c[nH]c5ncccc45)c3n2)cc1 CHEMBL2387468 Ki 0.61 nM
CS[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687443 IC50 0.61 nM
O[C@@H]1CNCCN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)C1 CHEMBL4113332 Ki 0.611 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CC[C@@H](N)C3)n2)cn1 CHEMBL4110731 Ki 0.615 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1cncn1 CHEMBL3687466 IC50 0.62 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691977 IC50 0.62 nM
CN1CCN(c2cccc(-c3c[nH]c4ccc(-c5nnc(N)s5)cc34)n2)CC1 CHEMBL3962808 IC50 0.625 nM
CC(C)(C)n1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3953482 Ki 0.636 nM
Cc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCC#N)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687493 IC50 0.64 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3687418 IC50 0.64 nM
c1cc(-c2n[nH]c3cnc(-n4ccnc4)cc23)nc(N2CCNCC2)c1 CHEMBL3634773 Ki 0.65 nM
c1cc(N2CCNCC2)nc(-n2ncc3cnc(-c4cncc(C5COC5)c4)cc32)c1 CHEMBL3965741 Ki 0.652 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC4(CCNCC4)C3)n2)n1 CHEMBL3956717 Ki 0.655 nM
CC(C)n1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3929264 Ki 0.656 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(NCC5CC5)n4)c3c2)o1 CHEMBL3890140 IC50 0.668 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)cn1 CHEMBL3961525 Ki 0.676 nM
NC(=O)Nc1cc2c(-c3cccc(N4CCNCC4)n3)n[nH]c2cn1 CHEMBL3634775 Ki 0.68 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1N=[N+]=[N-] CHEMBL3687497 IC50 0.68 nM
CN(C)Cc1nc2c(sc3ccc(-c4cccc(Cl)c4)cc32)c(=O)[nH]1 CHEMBL582844 Ki 0.7 nM
Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(NC4CCNCC4)n3)c2c1 CHEMBL3393697 IC50 0.7 nM
Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(OC4CNCCC45CC5)n3)c2c1 CHEMBL3393704 IC50 0.7 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1cc(CO)nn1 CHEMBL3687476 IC50 0.73 nM
CNc1nnc(-c2ccc3[nH]cc(-c4nccc(N5CCC[C@H](N)C5)n4)c3c2)s1 CHEMBL3946212 IC50 0.734 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1CCC(N)CC1 CHEMBL3652648 Ki 0.735 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691938 IC50 0.74 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687491 IC50 0.74 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cc(C3COC3)cc(N3CCC[C@H](N)C3)n2)n1 CHEMBL3906127 Ki 0.743 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC4CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1OCCC#N CHEMBL3691967 IC50 0.75 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC4CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3691943 IC50 0.75 nM
Cc1cc(F)c(-c2nc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691945 IC50 0.76 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cn(C)c(=O)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3969289 Ki 0.762 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(NC5CCCC5)n4)c3c2)s1 CHEMBL3394164 IC50 0.763 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C)cc3F)n2)C[C@@H]1C CHEMBL3687490 IC50 0.79 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc3c(n2)CC(CN)CO3)n1 CHEMBL3900881 Ki 0.796 nM
COc1cc(NCC2CCNCC2)nc2c1nnn2-c1cccc(OC(F)(F)F)c1 CHEMBL1952142 IC50 0.8 nM
C[C@H]1CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691940 IC50 0.8 nM
COc1ccc2c(c1CN1CCN[C@@H](C)C1)O/C(=C\c1n[nH]c3ncccc13)C2=O CHEMBL3735861 IC50 0.8 nM
Cc1cncc(-c2cc3c(ccn3-c3cccc(N4CCCNCC4)n3)cn2)n1 CHEMBL4070117 Ki 0.8 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CC[C@@H](N)C3)n2)n1 CHEMBL4111423 Ki 0.806 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(C3CCCNCC3)n2)cn1 CHEMBL3986159 Ki 0.806 nM
FC(F)Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3916902 Ki 0.814 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CC(O)C(O)C3)n2)n1 CHEMBL3934298 Ki 0.83 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691960 IC50 0.84 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CC[C@H](N)C3)n2)cn1 CHEMBL3924152 Ki 0.84 nM
Cc1cn([C@@H]2[C@H](N)CN(c3ccncc3NC(=O)c3ccc(F)c(-c4c(F)cccc4F)n3)C[C@@H]2C)nn1 CHEMBL3687420 IC50 0.86 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC(C)C)cc3F)n2)C[C@@H]1C CHEMBL3691926 IC50 0.87 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC(N)CC3)n2)cn1 CHEMBL3968140 Ki 0.87 nM
O=C1/C(=C/c2c[nH]c3nc(Cl)ccc23)Oc2c1ccc(O)c2CN1CCNCC1 CHEMBL4061176 IC50 0.88 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H]1C CHEMBL3691929 IC50 0.89 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cnc(Cl)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3947370 Ki 0.89 nM
CCc1ccc(-c2ccc3sc4c(=O)[nH]c(CN(C)C)nc4c3c2)cc1 CHEMBL572550 Ki 0.9 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)C[C@@H](N)[C@H]1OCCC#N CHEMBL3691968 IC50 0.9 nM
CC(C)Nc1cncc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3912741 IC50 0.901 nM
Cc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCS(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687483 IC50 0.91 nM
CC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687433 IC50 0.92 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC4CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3691921 IC50 0.93 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCC#N)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691949 IC50 0.95 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1OCCC#N CHEMBL3687495 IC50 0.96 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)cnc2N)c1N1CCC(N)CC1 CHEMBL3652633 Ki 0.962 nM
CC1CCCCN1c1ccnc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3932794 IC50 0.974 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1N CHEMBL3687430 IC50 0.99 nM
Nc1nnc(-c2ccc3[nH]cc(-c4nccc(C5CC5)n4)c3c2)o1 CHEMBL3893588 IC50 0.998 nM
CN(C)Cc1nc2c(sc3ccc(-c4ccc(C#N)cc4)cc32)c(=O)[nH]1 CHEMBL573702 Ki 1.0 nM
O=C(Nc1cnccc1OC1CCNCC1)c1csc(-c2c(F)cccc2F)n1 CHEMBL3354513 IC50 1.0 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1O[C@H]1CCNC1 CHEMBL3354518 IC50 1.0 nM
O=C(Nc1cnccc1OC1CCNCC1)c1cccc(-c2c(F)cccc2F)n1 CHEMBL3354521 IC50 1.0 nM
NC1CCN(c2cncc(-c3n[nH]c4ccc(-c5c(F)cccc5F)cc34)n2)CC1 CHEMBL3393692 IC50 1.0 nM
CC(C)Nc1cncc(-c2c[nH]c3ccc(-c4nnc(N)s4)cc23)n1 CHEMBL3394074 IC50 1.0 nM
c1cc(-c2n[nH]c3cnc(C4CCCOC4)cc23)nc(N2CCNCC2)c1 CHEMBL3634763 Ki 1.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)C12OCCO2 CHEMBL3687452 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)ccc(O)c3F)n2)C1 CHEMBL3652019 IC50 1.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(O)cc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3651899 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C1 CHEMBL3651947 IC50 1.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2cccc(-c3c(F)cccc3F)n2)C[C@@H](O)[C@@H]1O CHEMBL3652009 IC50 1.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)ccc(O)c3F)n2)C1 CHEMBL3652018 IC50 1.0 nM
Nc1cc(F)c(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@H]1C[C@@H](N)C[C@@H](C(F)(F)F)C1 CHEMBL3652004 IC50 1.0 nM
Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@H]1C[C@@H](N)C[C@@H](C(F)(F)F)C1 CHEMBL3652006 IC50 1.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](O)[C@@H]1O CHEMBL3652010 IC50 1.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2F)C[C@@H](N)[C@@H]1O CHEMBL3651920 IC50 1.0 nM
Nc1cc(F)c(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@@H]1CCC[C@H](N)C1 CHEMBL3651994 IC50 1.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(O)cc3F)n2)C1 CHEMBL3652022 IC50 1.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3ccccc3F)n2)C[C@@H](O)[C@@H]1O CHEMBL3652008 IC50 1.0 nM
N[C@@H]1CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)CC[C@@H]1O CHEMBL3676262 IC50 1.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(I)n(CC3CCNC3)c2n1 CHEMBL4093592 IC50 1.0 nM
Cc1cncc(-c2cc3c(-c4cccc(N5CCCNCC5)n4)nsc3cn2)n1 CHEMBL4081716 Ki 1.0 nM
CN1CCOc2c1cnn1c(-c3ccc4cc(Cl)cc(NCC5(F)CCNCC5)c4n3)nnc21 CHEMBL4457634 IC50 1.0 nM
COCc1cn([C@@H]2[C@H](N)CN(c3ccncc3NC(=O)c3ccc(F)c(-c4c(F)cccc4F)n3)C[C@@H]2C)nn1 CHEMBL3687427 IC50 1.02 nM
CC(C)Oc1cc(F)c(-c2nc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691931 IC50 1.03 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(C3=CCNCC3)n2)n1 CHEMBL3973175 Ki 1.06 nM
CC1CCCCN1c1cncc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3980131 IC50 1.061 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1OCC1CCNCC1 CHEMBL3652628 Ki 1.08 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnccc3C3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691916 IC50 1.08 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(N5CCC(F)(F)CC5)n4)c3c2)o1 CHEMBL3904783 IC50 1.083 nM
FC(F)n1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNCC3)n2)cn1 CHEMBL3981104 Ki 1.09 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1OC1CCNCC1 CHEMBL3652631 Ki 1.1 nM
COc1ccc2c(c1CN1CCNC[C@@H]1C)O/C(=C\c1n[nH]c3ncccc13)C2=O CHEMBL3735633 IC50 1.1 nM
CC(C)Oc1cccc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3901441 IC50 1.114 nM
NC1CN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)C1 CHEMBL3943778 Ki 1.14 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1cncn1 CHEMBL3687459 IC50 1.16 nM
C[C@H]1CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691978 IC50 1.17 nM
C[C@H]1NC(=O)c2cc(-c3cccc4c(=O)n(C)c(NC(C)(C)C)nc34)[nH]c21 CHEMBL3979678 Kd 1.2 nM
c1cc(C2CC2)nc(-c2c[nH]c3ccc(-c4nnc(NC5COC5)o4)cc23)n1 CHEMBL3952561 IC50 1.208 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CC4(CCCCN4)C3)n2)cn1 CHEMBL3975766 Ki 1.21 nM
CC1CCCN1c1ccnc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3971473 IC50 1.218 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCS(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691928 IC50 1.23 nM
CC(C)Oc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCS(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691925 IC50 1.24 nM
CCO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687498 IC50 1.24 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3687509 IC50 1.25 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C)cc3F)n2)C[C@@H]1C CHEMBL3687472 IC50 1.28 nM
COc1ccc2c(c1CN1CCNCC1)O/C(=C\c1c[nH]c3ncccc13)C2=O CHEMBL2147767 IC50 1.3 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CC[C@H](O)C3)n2)cn1 CHEMBL3901533 Ki 1.31 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC)cc3F)n2)C[C@@H]1C CHEMBL3691957 IC50 1.32 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)C[C@@H]1C CHEMBL3691942 IC50 1.32 nM
CC(C)Oc1cccc(-c2c[nH]c3ccc(-c4nnc(N5CC[C@@H](N)C5)s4)cc23)n1 CHEMBL3900578 IC50 1.321 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)ccc2N)c1N1CCC[C@H](CN)C1 CHEMBL3652636 Ki 1.33 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC4CCOCC4)cc3F)n2)C[C@@H](N)[C@@H]1OCCS(C)(=O)=O CHEMBL3691924 IC50 1.34 nM
FC(F)(F)Cn1cc(-c2cc3c(cn2)cnn3-c2cncc(N3CCCNCC3)n2)cn1 CHEMBL3900834 Ki 1.35 nM
O=C1CN(c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)CCN1 CHEMBL3634764 Ki 1.4 nM
CC(C)NC(=O)c1ccc(F)c(-c2ccc(N)c(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCC#N)[C@@H](C)C3)n2)c1 CHEMBL3687521 IC50 1.41 nM
CNc1nnc(-c2ccc3[nH]cc(-c4cncc(N5CCCCC5)n4)c3c2)s1 CHEMBL3930004 IC50 1.42 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C(C)C)cc3F)n2)C[C@@H]1C CHEMBL3687505 IC50 1.43 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H](N)[C@H]1S(C)(=O)=O CHEMBL3687525 IC50 1.44 nM
CCN(CC)c1cncc(-c2c[nH]c3ccc(-c4nnc(N)s4)cc23)n1 CHEMBL3892029 IC50 1.447 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC(C)C)cc3F)n2)C[C@@H]1C CHEMBL3687511 IC50 1.45 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(F)CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1OCCC#N CHEMBL3691937 IC50 1.45 nM
C[C@H]1CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691915 IC50 1.49 nM
CNc1nnc(-c2ccc3[nH]cc(-c4cccc(-n5cnc(C)c5)n4)c3c2)s1 CHEMBL3957552 IC50 1.498 nM
CCOCc1cc(F)c(-c2nc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691941 IC50 1.5 nM
CC(C)Oc1cccc(-c2c[nH]c3ccc(-c4nnc(N5CC[C@H](N)C5)s4)cc23)n1 CHEMBL3925087 IC50 1.511 nM
CCOCc1cc(F)c(-c2nc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](NC(=O)OC)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691986 IC50 1.52 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1Oc1ccccn1 CHEMBL3687532 IC50 1.53 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1cc(-c2ccsc2)nn1 CHEMBL3687417 IC50 1.54 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)C[C@@H](N)[C@@H]1OCCS(C)(=O)=O CHEMBL3691923 IC50 1.55 nM
CC(C)Oc1cccc(-c2c[nH]c3ccc(-c4nnc(N)s4)cc23)n1 CHEMBL3394167 IC50 1.579 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)C[C@@H]1C CHEMBL3687508 IC50 1.58 nM
OC1CN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)C1 CHEMBL3906850 Ki 1.58 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(C5CC5)n4)c3c2)o1 CHEMBL3896794 IC50 1.587 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(N5CCC(F)(F)C5)n4)c3c2)o1 CHEMBL3942435 IC50 1.604 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](NC(=O)OC)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687515 IC50 1.61 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1OCCS(C)(=O)=O CHEMBL3687487 IC50 1.62 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(NC3CCCCNC3)n2)cn1 CHEMBL3930402 Ki 1.62 nM
CC(C)Nc1ccnc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3908000 IC50 1.674 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(NCC5CC5)n4)c3c2)s1 CHEMBL3925863 IC50 1.676 nM
C[C@H]1CCCCN1c1cccc(-c2c[nH]c3ccc(-c4nnc(N)s4)cc23)n1 CHEMBL3900171 IC50 1.696 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCS(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691914 IC50 1.7 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1OCCS(C)(=O)=O CHEMBL3687527 IC50 1.74 nM
C[C@H]1CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H](N)[C@H]1C#N CHEMBL3687464 IC50 1.74 nM
Cc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691965 IC50 1.75 nM
FC(F)(F)Cn1cc(-c2cc3c(cn2)cnn3-c2ccnc(N3CCCNCC3)n2)cn1 CHEMBL3939262 Ki 1.76 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CC(O)C3)n2)cn1 CHEMBL3968874 Ki 1.78 nM
C[C@H]1CCCN(c2ccnc(-c3c[nH]c4ccc(-c5nnc(N)o5)cc34)n2)C1 CHEMBL3970168 IC50 1.785 nM
Cc1nnc(-c2cccc(-c3cnn4ccc(NCCN)nc34)c2)o1 CHEMBL2442291 IC50 1.8 nM
COc1ccc2c(c1CN1CCNCC1)O/C(=C\c1n[nH]c3ncccc13)C2=O CHEMBL3735816 IC50 1.8 nM
c1cc2[nH]cc(-c3cncc(C4CC4)n3)c2cc1-c1nnc(NC2CC2)o1 CHEMBL3892732 IC50 1.818 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(N5CCCCC5)n4)c3c2)o1 CHEMBL3930832 IC50 1.831 nM
CC(C)Oc1cccc(-c2c[nH]c3ccc(-c4nnc(N[C@@H]5CCCNC5)s4)cc23)n1 CHEMBL3985841 IC50 1.84 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cnc(O)c(N3CCC[C@H](N)C3)n2)n1 CHEMBL3920503 Ki 1.84 nM
NCC1CN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)C1 CHEMBL3926614 Ki 1.84 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OC)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687503 IC50 1.88 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@H]1S(C)(=O)=O CHEMBL3687524 IC50 1.88 nM
N[C@H]1CCCN(c2c(/C=C3\SC(=O)NC3=O)cccc2-c2ccccc2)C1 CHEMBL4793492 IC50 1.9 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691952 IC50 1.95 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(NC5CCCCC5)n4)c3c2)s1 CHEMBL3394165 IC50 1.988 nM
O=C(Nc1cnccc1O[C@H]1CCNC1)c1csc(-c2c(F)cccc2F)n1 CHEMBL3354511 IC50 2.0 nM
O=C(Nc1cnccc1O[C@H]1CC[C@H](O)CC1)c1csc(-c2c(F)cccc2F)n1 CHEMBL3354517 IC50 2.0 nM
Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(NC4CCCNC4)n3)c2c1 CHEMBL3393698 IC50 2.0 nM
Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(OC4CCNCC4)n3)c2c1 CHEMBL3393701 IC50 2.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3cc(O)ccc3F)n2)C1 CHEMBL3651942 IC50 2.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](O)[C@@H]1O CHEMBL3652011 IC50 2.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2cccc(-c3c(F)cc(O)cc3F)n2)C1 CHEMBL3651904 IC50 2.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1O CHEMBL3651981 IC50 2.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@H](O)[C@@H](C)C3)ccc2F)c1F CHEMBL3651940 IC50 2.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)C[C@H](N)C3)ccc2F)c1 CHEMBL3651955 IC50 2.0 nM
COc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)C[C@H](N)C3)ccc2F)c1 CHEMBL3651941 IC50 2.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)C[C@H](N)C3)ccc2F)c1F CHEMBL3651923 IC50 2.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2cccc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3651948 IC50 2.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3ccccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3651921 IC50 2.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@@H]3CCC[C@H](N)C3)n2)c1F CHEMBL3651924 IC50 2.0 nM
CC1(C)C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(O)cc3F)n2)C1 CHEMBL3652016 IC50 2.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](O)[C@@H]1O CHEMBL3652015 IC50 2.0 nM
Nc1cc(F)c(-c2ccccc2F)nc1C(=O)Nc1cnccc1[C@@H]1CC[C@H](O)[C@H](N)C1 CHEMBL3651962 IC50 2.0 nM
CC1(C)C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C1 CHEMBL3651945 IC50 2.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3ccccc3F)n2)C1 CHEMBL3651953 IC50 2.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](O)[C@@H](C)C3)ccc2F)c1F CHEMBL3651936 IC50 2.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3651946 IC50 2.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3ccncc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3652013 IC50 2.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(O)cc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3651900 IC50 2.0 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)CC(C)(C)C3)ccc2F)c(F)c1 CHEMBL3652017 IC50 2.0 nM
COc1cc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)C[C@@H](C(F)(F)F)C3)n2)c(F)c1 CHEMBL3652003 IC50 2.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3cc(O)ccc3F)ccc2F)C1 CHEMBL3651939 IC50 2.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3ccc(O)cc3F)n2)C1 CHEMBL3651905 IC50 2.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cc(O)cc3F)ccc2F)C1 CHEMBL3651938 IC50 2.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2cccc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1O CHEMBL3651972 IC50 2.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2cccc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3651922 IC50 2.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2cccc(-c3cc(O)ccc3F)n2)C1 CHEMBL3651903 IC50 2.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2cccc(-c3c(F)cccc3F)n2)C1 CHEMBL3651959 IC50 2.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)ccc(F)c3F)n2)C1 CHEMBL3652023 IC50 2.0 nM
N[C@H]1CCCN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676258 IC50 2.0 nM
C[C@@H]1C[C@H](N)CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676284 IC50 2.0 nM
COc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)C[C@H](N)C3)cs2)c1F CHEMBL3676305 IC50 2.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2csc(-c3c(F)cc(O)cc3F)n2)C1 CHEMBL3676310 IC50 2.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCCC(N)C3)c2n1 CHEMBL4095220 IC50 2.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCCNC3)c2n1 CHEMBL4084988 IC50 2.0 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@H](OC)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687533 IC50 2.02 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CC(CN)C3)n2)cn1 CHEMBL3913945 Ki 2.02 nM
C=C(C)c1cn([C@@H]2[C@H](N)C[C@H](c3ccncc3NC(=O)c3ccc(F)c(-c4c(F)cccc4F)n3)C[C@@H]2C)nn1 CHEMBL3691971 IC50 2.03 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCN(C4COC4)CC3)n2)n1 CHEMBL3900796 Ki 2.03 nM
Nc1nnc(-c2ccc3[nH]cc(-c4nccc(Nc5ccccc5)n4)c3c2)o1 CHEMBL3899404 IC50 2.066 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1S(=O)(=O)CCO CHEMBL3639862 IC50 2.07 nM
CC(C)NC(=O)c1ccc(F)c(-c2ccc(N)c(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)n2)c1 CHEMBL3691981 IC50 2.09 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691976 IC50 2.1 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C)cc3F)n2)C[C@@H]1C CHEMBL3687512 IC50 2.1 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(C)c(N3CCC[C@H](N)C3=O)n2)n1 CHEMBL3952989 Ki 2.13 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(-c5cccc(F)c5)n4)c3c2)o1 CHEMBL3981344 IC50 2.145 nM
COc1cc(-c2c[nH]c3ccc(-c4nnc(N)s4)cc23)nc(OC(C)C)n1 CHEMBL3904314 IC50 2.165 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@H](OC)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691927 IC50 2.17 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(F)CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691935 IC50 2.18 nM
c1cc(N2CCCNCC2)nc(-n2ncc3cnc(-c4cnn(CC5CC5)c4)cc32)c1 CHEMBL3944819 Ki 2.19 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C(C)(C)O)cc3F)n2)C[C@@H]1C CHEMBL3687507 IC50 2.2 nM
C[C@H]1COCCN1c1ccnc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3937011 IC50 2.211 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691944 IC50 2.22 nM
CNc1nnc(-c2ccc3[nH]cc(-c4cccc(OC(C)C)n4)c3c2)o1 CHEMBL3942256 IC50 2.256 nM
N[C@H]1CCCN(c2ccncc2NC(=O)c2csc(-c3ccccc3)n2)C1 CHEMBL3676302 IC50 2.3 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCCC3=O)n2)n1 CHEMBL3953849 Ki 2.3 nM
CCOCc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCS(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687534 IC50 2.39 nM
Nc1nnc(-c2ccc3[nH]cc(-c4nccc(-c5ccccc5)n4)c3c2)o1 CHEMBL3965031 IC50 2.397 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CCC(O)CC3)n2)cn1 CHEMBL3892590 Ki 2.46 nM
CC(C)Oc1cncc(-c2c[nH]c3ccc(-c4nnc(N)o4)cc23)n1 CHEMBL3965218 IC50 2.466 nM
Cn1ncc(NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)c1N1CCC[C@@H](N)CC1 CHEMBL3652643 Ki 2.48 nM
CCOCc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@H](OC)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691920 IC50 2.49 nM
COc1cc(NCC2CCNCC2)nc2c1nnn2-c1cccc(N(C)C)c1 CHEMBL1952143 IC50 2.5 nM
COc1ccc2c(c1C(C)N1CCNCC1)O/C(=C\c1n[nH]c3ncccc13)C2=O CHEMBL3735890 IC50 2.5 nM
CN1CCN(c2cccc(-c3c[nH]c4ccc(-c5nnc(N)s5)cc34)n2)CC1=O CHEMBL3910677 IC50 2.504 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC4CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691955 IC50 2.51 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3687414 IC50 2.52 nM
COC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H]1C CHEMBL3691959 IC50 2.52 nM
CN1CCN(c2cccc(-c3c[nH]c4ccc(-c5nnc(N)o5)cc34)n2)CC1 CHEMBL3960298 IC50 2.54 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)C[C@@H]1C CHEMBL3691922 IC50 2.58 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3)ccc2N)c1N1CCC(N)CC1 CHEMBL3652624 Ki 2.63 nM
CCO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C)cc3F)n2)C[C@@H]1C CHEMBL3687501 IC50 2.64 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691956 IC50 2.72 nM
CO[C@@]1(C)CNCCN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)C1 CHEMBL3950820 Ki 2.74 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(N5CCCCC5)n4)c3c2)s1 CHEMBL3967959 IC50 2.785 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4CCS(=O)(=O)CC4)cc3F)n2)C[C@@H]1C CHEMBL3687504 IC50 2.79 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1n1cc(C2CC2)nn1 CHEMBL3691970 IC50 2.87 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3691961 IC50 2.96 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cncc(N3CCCNCC3)n2)cn1 CHEMBL3953538 Ki 2.96 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cccc(OC5CCC5)n4)c3c2)s1 CHEMBL3914520 IC50 2.984 nM
CC(C)Oc1cncc(-c2c[nH]c3ccc(-c4nnc(N)s4)cc23)n1 CHEMBL3394171 IC50 2.999 nM
Nc1ccc(-c2c[nH]c3ccc(-c4cncc(N5CCCC(N)C5)n4)cc23)c(F)n1 CHEMBL1910909 IC50 3.0 nM
Nc1ccc(-c2ccccc2C(F)(F)F)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 CHEMBL3103865 Ki 3.0 nM
Nc1nccc(-c2ccc(N)c(C(=O)Nc3cnccc3N3CCC[C@H](N)C3)n2)n1 CHEMBL3103863 Ki 3.0 nM
Nc1ccc(-c2ccccn2)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 CHEMBL3103860 Ki 3.0 nM
Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(NC4CCNC4)n3)c2c1 CHEMBL3393699 IC50 3.0 nM
CC1(C)CCNCC1Oc1cncc(-c2n[nH]c3ccc(-c4c(F)cccc4F)cc23)n1 CHEMBL3393705 IC50 3.0 nM
CCOc1cccc(-c2c[nH]c3ccc(-c4nnc(N)s4)cc23)n1 CHEMBL3394166 IC50 3.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@H](O)[C@@H](C)C3)n2)c1F CHEMBL3651909 IC50 3.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2cccc(-c3ccc(O)cc3F)n2)C1 CHEMBL3651902 IC50 3.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@@H]3C[C@H](N)C[C@H](N)C3)n2)c1F CHEMBL3651925 IC50 3.0 nM
N[C@@H]1C[C@H](c2ccncc2NC(=O)c2cccc(-c3c(F)cccc3F)n2)CC[C@@H]1O CHEMBL3651974 IC50 3.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3ccc(O)cc3F)n2)C1 CHEMBL3651934 IC50 3.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3cc(O)ccc3F)n2)C1 CHEMBL3651929 IC50 3.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C1 CHEMBL3651993 IC50 3.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3cccc(F)c3F)n2)C1 CHEMBL3651956 IC50 3.0 nM
COc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@H](O)[C@@H](C)C3)ccc2F)c1F CHEMBL3651943 IC50 3.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3cccc(F)c3F)n2)C1 CHEMBL3651975 IC50 3.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2cccc(-c3ccccc3F)n2)C1 CHEMBL3651958 IC50 3.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2cccc(-c3ccccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3651919 IC50 3.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2cccc(-c3c(F)cc(O)cc3F)n2)C1 CHEMBL3651932 IC50 3.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(O)cc3F)n2)C1 CHEMBL3651928 IC50 3.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(C3CCCCC3)n2)C[C@@H](N)[C@@H]1O CHEMBL3651912 IC50 3.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3ccccc3F)n2)C[C@@H](N)[C@H]1O CHEMBL3651971 IC50 3.0 nM
CCCOc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3CC[C@H](O)[C@H](N)C3)c(N)cc2F)c1 CHEMBL3651963 IC50 3.0 nM
Nc1cc(F)c(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@@H]1CC[C@H](O)[C@H](N)C1 CHEMBL3651961 IC50 3.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)C[C@@H](C(F)(F)F)C3)n2)c1 CHEMBL3652002 IC50 3.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@H](O)[C@@H](C)C3)ccc2F)c1F CHEMBL3651918 IC50 3.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3ccc(F)cc3F)n2)C1 CHEMBL3651973 IC50 3.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2cccc(-c3cc(O)ccc3F)n2)C1 CHEMBL3651931 IC50 3.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)C[C@H](N)C3)n2)c1 CHEMBL3651954 IC50 3.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3CCC[C@H](N)C3)ccc2F)c1F CHEMBL3651916 IC50 3.0 nM
COCCOc1ccc2c(c1C(C)N1CCNCC1)O/C(=C\c1n[nH]c3ncccc13)C2=O CHEMBL3735657 IC50 3.0 nM
Nc1ccc(C2CCCCC2)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 CHEMBL3747207 Ki 3.0 nM
Nc1cc(-c2ccncc2NC(=O)c2nc(-c3ccccc3F)ccc2N)ccn1 CHEMBL3792428 Ki 3.0 nM
CC[C@@H]1C[C@H](N)CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676281 IC50 3.0 nM
N[C@H]1C[C@@H](C(F)(F)F)CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676283 IC50 3.0 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1N1CCC(F)CC1 CHEMBL3676286 IC50 3.0 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@@H]1CCC[C@H](N)C1 CHEMBL3676289 IC50 3.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3676292 IC50 3.0 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@@H]1CC[C@H](O)[C@H](N)C1 CHEMBL3676294 IC50 3.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676300 IC50 3.0 nM
CC1(C)C[C@H](N)C[C@H](c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676301 IC50 3.0 nM
CC(C)Oc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)C[C@H](N)C3)cs2)c1F CHEMBL3676306 IC50 3.0 nM
CCOc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)C[C@H](N)C3)cs2)c1F CHEMBL3676307 IC50 3.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2csc(-c3c(F)ccc(Cl)c3F)n2)C1 CHEMBL3676309 IC50 3.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCCNCC3)c2n1 CHEMBL4067797 IC50 3.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCC(N)CC3)c2n1 CHEMBL4070441 IC50 3.0 nM
C[C@@H]1C[C@H](O)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C1 CHEMBL3651898 Ki 3.0 nM
Cc1nnc2n1CCN(c1cccc(-c3c[nH]c4ccc(-c5nnc(N)s5)cc34)n1)C2 CHEMBL3930916 IC50 3.024 nM
COC(=O)N(C)[C@@H]1[C@H](C)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C[C@@H]1N CHEMBL3687456 IC50 3.04 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2nc(-c3cc(C(=O)NC(C)C)ccc3F)ccc2N)C[C@@H]1C CHEMBL3639908 IC50 3.05 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687485 IC50 3.08 nM
C[C@@]1(O)CNCCN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)C1 CHEMBL4109970 Ki 3.09 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3639863 IC50 3.1 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCNC3=O)n2)n1 CHEMBL3892308 Ki 3.16 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1NS(C)(=O)=O CHEMBL3687431 IC50 3.21 nM
CN1C(=O)CN(c2cc3c(-c4cccc(N5CCNCC5)n4)n[nH]c3cn2)C1=O CHEMBL3634776 Ki 3.3 nM
C[C@]1(O)CNCCN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)C1 CHEMBL3930725 Ki 3.36 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(NC5CC5)n4)c3c2)s1 CHEMBL3986124 IC50 3.394 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCCC4(CN(C=O)C4)C3)n2)n1 CHEMBL3972017 Ki 3.42 nM
CC(C)Oc1cccc(-c2c[nH]c3ccc(-c4nnc(NC5CCCNC5)s4)cc23)n1 CHEMBL3901647 IC50 3.456 nM
COC(=O)N[C@@H]1[C@H](N)CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(F)CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3691982 IC50 3.56 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687502 IC50 3.69 nM
Cn1cc(-c2cc3c(-c4ccccn4)n[nH]c3cn2)cn1 CHEMBL3634766 Ki 3.7 nM
CCOCc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OC)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687510 IC50 3.73 nM
CN(C)[C@H]1CCCN(c2ccnc(-c3c[nH]c4ccc(-c5nnc(N)o5)cc34)n2)C1 CHEMBL3973417 IC50 3.743 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)ccc2N)c1N1CC[C@@H](N)C1 CHEMBL3652635 Ki 3.79 nM
Cc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](S(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687531 IC50 3.84 nM
CN(C)c1cncc(-c2c[nH]c3ccc(-c4nnc(N)s4)cc23)n1 CHEMBL3922231 IC50 3.86 nM
CNc1nnc(-c2ccc3[nH]cc(-c4nccc(N5CCN(C)CC5)n4)c3c2)s1 CHEMBL3960208 IC50 3.981 nM
Nc1nnc(-c2ccc3[nH]cc(-c4ccnc(N5CCOCC5)n4)c3c2)s1 CHEMBL3959112 IC50 3.999 nM
O=c1[nH]c(CNc2cccc(O)c2)nc2c1sc1ccc(Br)cc12 CHEMBL584161 Ki 4.0 nM
Nc1ccc(-c2c[nH]c3ccc(-c4cncc(N5CCNCC5)n4)cc23)c(F)n1 CHEMBL1910908 IC50 4.0 nM
O=c1[nH]c(CN2CC[C@@H](O)C2)nc2c1oc1ccc(Br)cc12 CHEMBL2030386 IC50 4.0 nM
N[C@@H]1CCCN(c2c(/C=C3\SC(=O)NC3=O)cccc2-c2ccncc2)C1 CHEMBL2048873 IC50 4.0 nM
Nc1ccc(-c2cccnc2)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 CHEMBL3103861 Ki 4.0 nM
C=C1CCNCC1Oc1cncc(-c2n[nH]c3ccc(-c4c(F)cccc4F)cc23)n1 CHEMBL3393703 IC50 4.0 nM
NC1CCCN(c2cncc(-c3n[nH]c4ccc(-c5c(F)cccc5F)cc34)n2)C1 CHEMBL3393722 IC50 4.0 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(N5CCOCC5)n4)c3c2)s1 CHEMBL3394073 IC50 4.0 nM
CC1CC(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)=CC(O)C1 CHEMBL3651999 IC50 4.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)CC(C)(C)C3)n2)c1F CHEMBL3651908 IC50 4.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](O)[C@@H](C)C3)n2)c1F CHEMBL3651927 IC50 4.0 nM
Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@@H]1CC[C@H](O)[C@H](N)C1 CHEMBL3651996 IC50 4.0 nM
CCCOc1ccc(F)c(-c2ccc(N)c(C(=O)Nc3cnccc3[C@@H]3CC[C@H](O)[C@H](N)C3)n2)c1 CHEMBL3651964 IC50 4.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3cc(F)ccc3F)n2)C1 CHEMBL3651957 IC50 4.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](O)[C@@H](C)C3)n2)c1 CHEMBL3651970 IC50 4.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](O)[C@@H](C)C3)ccc2F)c1 CHEMBL3651969 IC50 4.0 nM
Cc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)CC(C)(C)C3)ccc2F)c1F CHEMBL3651907 IC50 4.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@H](O)[C@@H](C)C3)n2)c1F CHEMBL3651926 IC50 4.0 nM
C[C@@H]1CN(c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)C[C@@H](N)[C@H]1O CHEMBL3651997 IC50 4.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1F CHEMBL3652031 IC50 4.0 nM
COc1ccc2c(c1CN1CCN[C@H](C)C1)O/C(=C\c1n[nH]c3ncccc13)C2=O CHEMBL3736117 IC50 4.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676290 Ki 4.0 nM
N[C@@H]1CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)CC[C@H]1O CHEMBL3676259 IC50 4.0 nM
NC1CC(C(F)(F)F)CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676271 IC50 4.0 nM
NC1CC(CF)CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676272 IC50 4.0 nM
N[C@@H]1CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)CC(F)(F)C1 CHEMBL3676280 IC50 4.0 nM
C[C@@H]1C[C@H](O)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)sc2N)C1 CHEMBL3676288 IC50 4.0 nM
NC(=O)c1cc(Cl)c2c(Cl)c(I)n(C3CCNCC3)c2n1 CHEMBL4077977 IC50 4.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 4.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3ncccc3F)ccc2N)C[C@@H](O)[C@]1(C)O CHEMBL4781112 Ki 4.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccnc(-c3c(F)cccc3F)n2)C[C@@H](O)[C@]1(C)O CHEMBL4791128 Ki 4.0 nM
CC(C)NC(=O)c1ccc(F)c(-c2ccc(N)c(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](OCCS(C)(=O)=O)[C@@H](C)C3)n2)c1 CHEMBL3687537 IC50 4.11 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cccc(-n5cccn5)n4)c3c2)o1 CHEMBL3981772 IC50 4.132 nM
COc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](S(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687522 IC50 4.15 nM
N[C@H]1CCCN(c2ccncc2NC(=O)c2csc(-c3ccccc3F)n2)C1 CHEMBL3676303 IC50 4.2 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(-c5cccc(Cl)c5)n4)c3c2)o1 CHEMBL3952591 IC50 4.228 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(C3(O)CCCNCC3)n2)cn1 CHEMBL3959083 Ki 4.32 nM
CCn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CC[C@@H](O)C3)n2)cn1 CHEMBL4106807 Ki 4.39 nM
COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1ccc(s1)-c1ncnc3c(C)c-2sc13 CHEMBL4860369 IC50 4.39 nM
c1cc(-c2n[nH]c3cnc(N4CCOCC4)cc23)nc(N2CCNCC2)c1 CHEMBL3634765 Ki 4.4 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(F)CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3687536 IC50 4.51 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cccc(OC5CCCC5)n4)c3c2)s1 CHEMBL3394168 IC50 4.579 nM
CCOCc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3691939 IC50 4.81 nM
Nc1sc(-c2c(F)cccc2F)nc1C(=O)Nc1cn[nH]c1N1CCC[C@H](N)C1 CHEMBL3652621 Ki 4.89 nM
CC1(C)CNc2ncc(-c3c[nH]c4ccc(-c5nnc(N)s5)cc34)nc21 CHEMBL3935173 IC50 4.928 nM
Nc1nnc(-c2ccc3[nH]cc(-c4nccc(-c5ccccc5F)n4)c3c2)o1 CHEMBL3904737 IC50 4.967 nM
Cn1ncc(NC(=O)c2nc(-c3ccccc3F)ccc2N)c1OC1CCNCC1 CHEMBL3652629 Ki 4.97 nM
Nc1ccc(-c2c[nH]c3ccc(-c4cncc(O[C@H]5CC[C@H](N)CC5)n4)cc23)c(F)n1 CHEMBL1910907 IC50 5.0 nM
CC[C@H](N)COc1cncc(-c2ccc3[nH]cc(-c4ccc(N)nc4F)c3c2)n1 CHEMBL1910911 IC50 5.0 nM
Nc1ccc(-c2c[nH]c3ccc(-c4cncc(OC[C@H](N)c5ccccc5)n4)cc23)c(F)n1 CHEMBL1910915 IC50 5.0 nM
O=C(CCN1CCCCC1)Nc1ccc(-c2nc3c(oc4ccc(Br)cc43)c(=O)[nH]2)c(Cl)c1 CHEMBL2035629 IC50 5.0 nM
N[C@H]1CCN(c2cc(Cl)ccc2/C=C2\SC(=O)NC2=O)C1 CHEMBL2046468 IC50 5.0 nM
Nc1ccc(-c2ccncc2)nc1C(=O)Nc1cnccc1N1CCC[C@H](N)C1 CHEMBL3103862 Ki 5.0 nM
O=C(Nc1cnccc1OC1CCOCC1)c1csc(-c2c(F)cccc2F)n1 CHEMBL3354515 IC50 5.0 nM
Fc1cccc(F)c1-c1nc(-c2ccc3nccc(N4CCNCC4)c3c2)cs1 CHEMBL3354523 IC50 5.0 nM
Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(OC4CCCNC4)n3)c2c1 CHEMBL3393702 IC50 5.0 nM
CC(C)Nc1cccc(-c2c[nH]c3ccc(-c4nnc(N)s4)cc23)n1 CHEMBL3394068 IC50 5.0 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cccc(NC5CCCC5)n4)c3c2)s1 CHEMBL3394069 IC50 5.0 nM
c1ccc(-c2n[nH]c3cnc(-c4cccnc4)cc23)cc1 CHEMBL3634790 Ki 5.0 nM
Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1C1=C[C@@H](N)[C@@H](O)CC1 CHEMBL3651988 IC50 5.0 nM
CCc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](O)[C@@H](C)C3)n2)c1F CHEMBL3651913 IC50 5.0 nM
CC(=O)O[C@H]1CC[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)C[C@H]1N CHEMBL3651995 IC50 5.0 nM
Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1[C@@H]1CC[C@H](O)[C@@H](N)C1 CHEMBL3651998 IC50 5.0 nM
N[C@@H]1C[C@H](c2ccncc2NC(=O)c2cccc(-c3ccccc3F)n2)CC[C@@H]1O CHEMBL3651979 IC50 5.0 nM
N[C@@H]1C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3ccccc3F)n2)CC[C@@H]1O CHEMBL3651983 IC50 5.0 nM
Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1C1=CC(N)C(O)CC1 CHEMBL3651987 IC50 5.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)C[C@@H](N)[C@H]1O CHEMBL3651989 IC50 5.0 nM
CCCOc1ccc(F)c(-c2nc(C(=O)Nc3cnccc3[C@@H]3CC[C@H](O)[C@H](N)C3)ccc2F)c1 CHEMBL3651960 IC50 5.0 nM
Cc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@@H]3CC[C@H](O)[C@H](N)C3)n2)c1F CHEMBL3651937 IC50 5.0 nM
N[C@@H]1C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)CC[C@@H]1O CHEMBL3651984 IC50 5.0 nM
C[C@@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)C[C@@H](N)[C@H]1O CHEMBL3651992 IC50 5.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2cccc(-c3ccc(O)cc3F)n2)C1 CHEMBL3651933 IC50 5.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3cc(F)ccc3F)n2)C1 CHEMBL3651977 IC50 5.0 nM
Nc1cc(-c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)ncn1 CHEMBL3793221 Ki 5.0 nM
Nc1nccc(-c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)n1 CHEMBL3793267 Ki 5.0 nM
N[C@@H]1CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)CC[C@H]1F CHEMBL3676260 IC50 5.0 nM
CC1CC(N)CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676270 IC50 5.0 nM
CC1CCN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)CC1N CHEMBL3676275 IC50 5.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2csc(-c3c(F)ccc(F)c3F)n2)C1 CHEMBL3676308 IC50 5.0 nM
CC[C@]1(O)[C@H](O)C[C@H](c2ccncc2NC(=O)c2nc(-c3ncccc3F)ccc2N)C[C@@H]1C CHEMBL4742957 Ki 5.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1S(C)(=O)=O CHEMBL3687447 IC50 5.03 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(F)CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3687506 IC50 5.07 nM
CO/N=C1\[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687426 IC50 5.09 nM
Nc1nnc(-c2ccc3[nH]cc(-c4nccc(N5CCC[C@@H](O)C5)n4)c3c2)o1 CHEMBL4113485 IC50 5.099 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1n1ccnn1 CHEMBL3691963 IC50 5.16 nM
CS[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687445 IC50 5.24 nM
COCCOc1cc(F)c(-c2nc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](S(C)(=O)=O)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687528 IC50 5.25 nM
CN1CCC(c2c(NC(=O)c3nc(-c4c(F)cccc4F)sc3N)cnn2C)CC1 CHEMBL3652642 Ki 5.26 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cccc(N5CCCC5=O)n4)c3c2)s1 CHEMBL3896735 IC50 5.335 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687460 IC50 5.35 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(-c5ccccc5)n4)c3c2)o1 CHEMBL3967996 IC50 5.357 nM
CO[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ncc2N)C[C@@H]1C CHEMBL3687489 IC50 5.36 nM
O=C(Nc1ccc(F)cc1)c1cnn2c(O)cc(C3CCNCC3)nc12 CHEMBL2387466 Ki 5.4 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC4CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1S(C)(=O)=O CHEMBL3687517 IC50 5.42 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(F)CCOCC4)cc3F)n2)C[C@@H](N)[C@H]1OCCS(C)(=O)=O CHEMBL3691913 IC50 5.44 nM
Cn1cc(-c2cncc(-c3c[nH]c4ccc(-c5nnc(N)o5)cc34)n2)cn1 CHEMBL3892287 IC50 5.542 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cccc(N5CCOCC5)n4)c3c2)s1 CHEMBL3394067 IC50 5.587 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CC4(CNC4)C3)n2)cn1 CHEMBL3970681 Ki 5.65 nM
Nc1nnc(-c2ccc3[nH]cc(-c4nccc(Oc5ccccc5)n4)c3c2)o1 CHEMBL3951570 IC50 5.689 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1C#N CHEMBL3687467 IC50 5.71 nM
CCCOc1cccc(-c2c[nH]c3ccc(-c4nnc(N)s4)cc23)n1 CHEMBL3933697 IC50 5.73 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cccc(N5CCOCC5)n4)c3c2)o1 CHEMBL3890347 IC50 5.743 nM
COc1ncc2cc1NS(=O)(=O)c1ccc(F)c(c1)C(=O)NCc1ccc(s1)-c1ncnc3c(C)c-2sc13 CHEMBL4878958 IC50 5.75 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1NCC1CCNCC1 CHEMBL3652622 Ki 5.77 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C4(O)CCC4)cc3F)n2)C[C@@H](N)[C@H]1S(C)(=O)=O CHEMBL3687518 IC50 5.81 nM
O=Cc1c[nH]c2c1ccc1c3cccc(C(F)(F)F)c3[nH]c12 CHEMBL1243129 IC50 6.0 nM
CC(C)[C@H](N)COc1cncc(-c2ccc3[nH]cc(-c4ccc(N)nc4F)c3c2)n1 CHEMBL1910912 IC50 6.0 nM
N[C@@H]1CCN(Cc2nc3c(oc4ccc(Br)cc43)c(=O)[nH]2)C1 CHEMBL2030388 IC50 6.0 nM
CCOc1cccc(/C=C2\SC(=O)NC2=O)c1N1CCC[C@@H](N)C1 CHEMBL2048869 IC50 6.0 nM
NC1CCN(c2cncc(-c3n[nH]c4ccc(-c5c(F)cccc5F)cc34)n2)C1 CHEMBL3393693 IC50 6.0 nM
Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(N4CCNCC4)n3)c2c1 CHEMBL3393695 IC50 6.0 nM
Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(NC4CNC4)n3)c2c1 CHEMBL3393700 IC50 6.0 nM
N[C@H]1CCCN(c2ccncc2-c2cc3c(-c4ccccc4F)n[nH]c3cn2)C1 CHEMBL3634793 Ki 6.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2nc(-c3cc(O)ccc3F)ccc2F)C1 CHEMBL3651930 IC50 6.0 nM
C[C@@H]1C[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2F)C1 CHEMBL3651965 IC50 6.0 nM
CCc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@@H]3C[C@H](C)C[C@H](N)C3)n2)c1F CHEMBL3651917 IC50 6.0 nM
C[C@@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](O)[C@H]1O CHEMBL3652030 IC50 6.0 nM
CC1(C)C[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3ccc(O)cc3F)n2)C1 CHEMBL3651906 IC50 6.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@H]1O CHEMBL3652025 IC50 6.0 nM
CCc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@H](O)[C@@H](C)C3)n2)c1F CHEMBL3651911 IC50 6.0 nM
Nc1ccc(-c2c(F)cccc2F)nc1C(=O)Nc1cnccc1C1=CC(N)CCC1 CHEMBL3652001 IC50 6.0 nM
C[C@@H]1C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)C[C@H](N)[C@H]1O CHEMBL3651990 IC50 6.0 nM
Nc1cncc(-c2ccncc2NC(=O)c2nc(-c3ccccc3F)ccc2N)n1 CHEMBL3792474 Ki 6.0 nM
CN1CCC(n2c(I)c(Cl)c3c(Cl)cc(C(N)=O)nc32)CC1 CHEMBL4070019 IC50 6.0 nM
CN1CCOc2c1cnn1c(-c3ccc4ccc(Cl)c(NCC5(F)CCNCC5)c4n3)nnc21 CHEMBL4483071 IC50 6.0 nM
CN1CCOc2c1cnn1c(-c3ccc4ccnc(NCC5CCNCC5)c4c3)nnc21 CHEMBL4555990 IC50 6.0 nM
FC(F)(F)Cn1cc(-c2cc3c(cn2)cnn3-c2cccc(N3CC4(CNC4)C3)n2)cn1 CHEMBL3899519 Ki 6.01 nM
Cn1ncc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)c1C1CCNCC1 CHEMBL3652644 Ki 6.12 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cn(C)c(=O)c(N3CCNCC(O)C3)n2)cn1 CHEMBL3929332 Ki 6.24 nM
Cc1cc(F)c(-c2nc(C(=O)Nc3cnccc3N3C[C@@H](N)[C@@H](C#N)[C@@H](C)C3)ccc2F)c(F)c1 CHEMBL3687465 IC50 6.29 nM
Cc1cncc(-c2cc3c(cn2)cnn3-c2ccc(=O)n([C@H]3CCCNC3)n2)n1 CHEMBL3918384 Ki 6.31 nM
COc1ccc(-c2c[nH]c3ccc(-c4nnc(N)s4)cc23)nc1OC CHEMBL3948227 IC50 6.339 nM
COC1(C)CNCCN(c2cccc(-n3ncc4cnc(-c5cnn(CC(F)(F)F)c5)cc43)n2)C1 CHEMBL3914110 Ki 6.37 nM
CC(c1c(OCCO)ccc2c1O/C(=C\c1n[nH]c3ncccc13)C2=O)N1CCNCC1 CHEMBL3735412 IC50 6.4 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(N5CCOCC5)n4)c3c2)o1 CHEMBL3964669 IC50 6.455 nM
CN(C)CCNc1cncc(-c2ccc3[nH]cc(-c4ccnc(N)n4)c3c2)n1 CHEMBL3264257 IC50 6.5 nM
COC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(C)cc3F)n2)C[C@@H]1C CHEMBL3691964 IC50 6.68 nM
c1cc(N2CCCNCC2)nc(-n2ncc3cnc(-c4cncnc4)cc32)c1 CHEMBL3960858 Ki 6.72 nM
CNc1nnc(-c2ccc3[nH]cc(-c4cccc(N5CCCC5=O)n4)c3c2)s1 CHEMBL3942495 IC50 6.728 nM
c1cc2[nH]cc(-c3cncc(C4CC4)n3)c2cc1-c1nnc(N2CCCC2)o1 CHEMBL3914961 IC50 6.777 nM
COCCS(=O)(=O)[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H]1C CHEMBL3687432 IC50 6.78 nM
CC(C)NC(=O)c1ccc(F)c(-c2ccc(N)c(C(=O)Nc3cnccc3[C@H]3C[C@@H](N)[C@@H](n4ccnn4)[C@@H](C)C3)n2)c1 CHEMBL3691980 IC50 6.9 nM
FC(F)(F)Oc1cccc(-n2nnc3ccc(NCC4CCNCC4)nc32)c1 CHEMBL1952113 IC50 7.0 nM
O=C(Nc1cnccc1OCC1CCOCC1)c1csc(-c2c(F)cccc2F)n1 CHEMBL3354516 IC50 7.0 nM
Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(N4CCCNCC4)n3)c2c1 CHEMBL3393694 IC50 7.0 nM
Nc1ncc(-c2ccc3[nH]nc(-c4cnc5ccccc5c4)c3c2)s1 CHEMBL3394059 IC50 7.0 nM
CCc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@@H]3CC[C@H](O)[C@H](N)C3)n2)c1F CHEMBL3651914 IC50 7.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3ccncc3)n2)C[C@@H](N)[C@@H]1O CHEMBL3652014 IC50 7.0 nM
CCCOc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@@H]3CC[C@H](O)[C@H](N)C3)n2)c1 CHEMBL3651980 IC50 7.0 nM
CC1CC(c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)=CC(O)C1 CHEMBL3652029 IC50 7.0 nM
CCc1ccc(F)c(-c2cccc(C(=O)Nc3cnccc3[C@@H]3CCC[C@H](N)C3)n2)c1F CHEMBL3651915 IC50 7.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2F)C1 CHEMBL3651976 IC50 7.0 nM
C[C@@H]1C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ccc2N)C[C@@H](N)[C@H]1O CHEMBL3651991 IC50 7.0 nM
NCCNc1cncc(-c2ccc3[nH]cc(-c4ccccc4F)c3c2)n1 CHEMBL4125725 IC50 7.0 nM
CC(=O)c1ccc(F)c(-c2c[nH]c3ccc(-c4cncc(NCCN(C)C)n4)cc23)c1 CHEMBL4125914 IC50 7.0 nM
CN1CCOc2c1cnn1c(-c3ccc4cc(F)cc(NCC5(F)CCNCC5)c4n3)nnc21 CHEMBL4564783 IC50 7.0 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(-c5ccc(Cl)cc5)n4)c3c2)o1 CHEMBL3922724 IC50 7.02 nM
c1cc2[nH]cc(-c3cncc(C4CC4)n3)c2cc1-c1nnc(N2CCNCC2)o1 CHEMBL3927004 IC50 7.106 nM
CCOc1cccc(-c2c[nH]c3ccc(-c4nnc(NC)s4)cc23)n1 CHEMBL3968565 IC50 7.131 nM
CN1CCN(c2cncc(-c3c[nH]c4ccc(-c5nnc(N)s5)cc34)n2)CC1=O CHEMBL3957441 IC50 7.406 nM
CC(C)Oc1ccc(F)c(-c2c[nH]c3ccc(-c4nnc(N)o4)nc23)c1 CHEMBL3923772 IC50 7.683 nM
Nc1nnc(-c2ccc3[nH]cc(-c4nccc(N5CCOCC5)n4)c3c2)s1 CHEMBL3899208 IC50 7.686 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3cc(C(=O)NC(C)C)ccc3F)ccc2N)C[C@@H]1C CHEMBL3687535 IC50 7.78 nM
CN(C)CCN(C)c1cncc(-c2ccc3[nH]cc(-c4ccnc(N)n4)c3c2)n1 CHEMBL3264261 IC50 7.8 nM
CCOc1cncc(-c2c[nH]c3ccc(-c4nnc(N)s4)cc23)n1 CHEMBL3394170 IC50 7.803 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(-c5ccccc5F)n4)c3c2)o1 CHEMBL3938446 IC50 7.814 nM
c1cc2[nH]cc(-c3cncc(C4CC4)n3)c2cc1-c1nnc(N2CCOCC2)o1 CHEMBL3959316 IC50 7.94 nM
COc1cc(C=C2SC(=S)NC2=O)ccc1O CHEMBL1973098 pKi 7.943 nM
S=c1[nH]nc2c3c4c(sc3n3c(=S)[nH]nc3n12)CCC4 CHEMBL1969537 pKi 7.943 nM
COC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC(C)C)cc3F)n2)C[C@@H]1C CHEMBL3691933 IC50 7.97 nM
O=c1[nH]c(-c2cccc(Cl)c2Cl)nc2c1oc1ccc(Br)cc12 CHEMBL2035623 IC50 8.0 nM
NCc1ccc(-c2nc3c(oc4ccc(Br)cc43)c(=O)[nH]2)c(Cl)c1 CHEMBL2035626 IC50 8.0 nM
O=c1[nH]c(-c2ccc(CNC3CCNCC3)cc2Cl)nc2c1oc1ccc(Br)cc12 CHEMBL2035628 IC50 8.0 nM
O=c1[nH]c(-c2ccc(NCC3CCNCC3)cc2)nc2c1oc1ccc(Br)cc12 CHEMBL2035630 IC50 8.0 nM
C[C@@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1O CHEMBL3652026 IC50 8.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)c(F)cc2N)C[C@@H](N)[C@@H]1O CHEMBL3652024 IC50 8.0 nM
N[C@H]1C[C@@H](F)CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676267 IC50 8.0 nM
N[C@H]1C[C@H](F)CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676273 IC50 8.0 nM
C[C@@H]1C[C@H](O)C[C@H](c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C1 CHEMBL3676287 IC50 8.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3676297 IC50 8.0 nM
CC(C)(C)c1cncc(-c2cc3c(cn2)cnn3-c2cccc(N3CCNCC3)n2)n1 CHEMBL3909176 Ki 8.02 nM
CO[C@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2nc(-c3c(F)cccc3F)ncc2N)C[C@@H]1C CHEMBL3687480 IC50 8.19 nM
CC(C)NC(=O)c1ccc(F)c(-c2nc(C(=O)Nc3cnccc3N3CCC[C@H](N)C3)cs2)c1 CHEMBL3676304 IC50 8.3 nM
CC1CCN(c2cncc(-c3c[nH]c4ccc(-c5nnc(N)s5)cc34)n2)CC1 CHEMBL3965029 IC50 8.537 nM
Cn1cc(-c2cc3c(cn2)cnn3-c2cn(C)c(=O)c(N3CCC[C@@H](N)C3)n2)cn1 CHEMBL4110528 Ki 8.64 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1OS(C)(=O)=O CHEMBL3687450 IC50 8.75 nM
Cn1cc(NC(=O)c2nc(-c3c(F)cccc3F)sc2N)cn1 CHEMBL3652620 Ki 8.8 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1N=[N+]=[N-] CHEMBL3687440 IC50 8.88 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cccc(N5CCCC5)n4)c3c2)s1 CHEMBL3394066 IC50 8.912 nM
CN1C[C@@H]2C[C@H]1CN2Cc1nc2c(oc3ccc(Br)cc32)c(=O)[nH]1 CHEMBL2035635 IC50 9.0 nM
N[C@@H]1CCCN(c2ccccc2/C=C2\SC(=O)NC2=O)C1 CHEMBL2048865 IC50 9.0 nM
Nc1nnc(-c2ccc3[nH]cc(-c4cncc(N5CCCC5)n4)c3c2)s1 CHEMBL3394072 IC50 9.0 nM
Cc1n[nH]c2cnc(-c3cncc(N4CCC(N)CC4)n3)cc12 CHEMBL3634778 Ki 9.0 nM
Nc1cc(F)c(-c2ccncc2F)nc1C(=O)Nc1cnccc1[C@@H]1CCC[C@H](N)C1 CHEMBL3652028 IC50 9.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2cccc(-c3cc(F)cc(F)c3F)n2)C1 CHEMBL3651944 IC50 9.0 nM
N[C@H]1CCC[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3ccc(F)cc3F)n2)C1 CHEMBL3651978 IC50 9.0 nM
C[C@H]1CN(c2ccncc2NC(=O)c2ccc(F)c(-c3cccnc3)n2)C[C@@H](N)[C@@H]1O CHEMBL3652012 IC50 9.0 nM
C[C@H]1C[C@@H](c2ccncc2NC(=O)c2ccc(F)c(-c3cc(O)ccc3F)n2)C[C@@H](N)[C@@H]1O CHEMBL3651901 IC50 9.0 nM
C[C@@H]1CN(c2ccncc2NC(=O)c2csc(-c3c(F)cccc3F)n2)C[C@@H](N)[C@H]1O CHEMBL3676291 IC50 9.0 nM
CN(C)CCNc1cncc(-c2ccc3[nH]cc(-c4ccc(N)cc4F)c3c2)n1 CHEMBL4129087 IC50 9.0 nM
Cc1cn(-c2nc(-c3c[nH]c4ccc(-c5nnc(N)s5)cc34)cs2)cn1 CHEMBL3911843 IC50 9.468 nM
COC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC)cc3F)n2)C[C@@H]1C CHEMBL3691975 IC50 9.71 nM
COC(=O)N[C@@H]1[C@H](N)C[C@H](c2ccncc2NC(=O)c2ccc(F)c(-c3c(F)cc(OC4CCOCC4)cc3F)n2)C[C@@H]1C CHEMBL3691954 IC50 9.86 nM
CCc1nnc(-c2ccc3[nH]cc(-c4cncc(N(C)C)n4)c3c2)s1 CHEMBL3915618 IC50 9.888 nM
CCN(CC)CCNc1cncc(-c2ccc3[nH]cc(-c4ccnc(N)n4)c3c2)n1 CHEMBL3264258 IC50 9.9 nM