CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3cccc(C)c3F)cc2)nc2cnccc12)C(=O)O CHEMBL4802045 IC50 1.0 nM
CC[C@H](Nc1c(C#N)c(-c2ccc(-c3cccc(C)c3F)cc2)nc2cnccc12)C(=O)O CHEMBL4802048 IC50 1.0 nM
CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3cccc(Cl)c3F)cc2)nc2cnccc12)C(=O)O CHEMBL5280127 IC50 2.0 nM
CCOc1ccccc1-c1ccc(-c2nc3cnccc3c(N[C@H](CC)C(=O)O)c2C#N)cc1 CHEMBL5276719 IC50 5.0 nM
CCOc1ccccc1-c1ccc(-c2nc3cncc(Cl)c3c(N[C@H](CC)C(N)=O)c2C#N)cc1 CHEMBL5270765 IC50 7.0 nM
COc1ccc(Nc2ncnc3c2ccn3-c2ccc(C)c(C)c2)cc1Cl CHEMBL5288342 pIC50 10.0 nM
CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3cccc(Cl)c3F)cc2)nc2cnccc12)C(N)=O CHEMBL5290005 IC50 13.0 nM
CCOc1ccccc1-c1ccc(-c2nc3cnccc3c(NC(C)C(=O)O)c2C#N)cc1 CHEMBL5271652 IC50 14.0 nM
CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3cccc(C)c3F)cc2)nc2cnccc12)C(N)=O CHEMBL5277824 IC50 19.0 nM
COc1ccc(Nc2ncnc3c2ccn3-c2ccc(C)cc2C)cc1Cl CHEMBL5277633 pIC50 19.95 nM
CCOc1ccccc1-c1ccc(-c2nc3cnccc3c(N[C@H](CC)C(=O)NS(=O)(=O)C3CC3)c2C#N)cc1 CHEMBL5288492 IC50 30.0 nM
CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3ccccc3F)cc2)nc2cnccc12)C(N)=O CHEMBL5282226 IC50 37.0 nM
COc1ccc(-n2ccc3c(Nc4ccc(OC)c(Cl)c4)ncnc32)cc1 CHEMBL5275392 pIC50 39.81 nM
CCOc1ccccc1-c1ccc(-c2nc3cnccc3c(N[C@H](CC)C(=O)NS(C)(=O)=O)c2C#N)cc1 CHEMBL5284796 IC50 40.0 nM
CN1C(=O)[C@@H](CC2CCCC2)N(C2CCCC2)c2nc(Nc3cc(Cl)c(O)c(Cl)c3)ncc21 CHEMBL5271804 IC50 40.0 nM
CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3ccccc3OC)cc2)nc2cnccc12)C(N)=O CHEMBL5273876 IC50 42.0 nM
CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3ccc(F)cc3OC)cc2)nc2cnccc12)C(N)=O CHEMBL5272762 IC50 47.0 nM
CSc1ccc(Nc2ncnc3cc(-c4cccnc4Cl)sc23)cc1 CHEMBL5420914 pIC50 50.12 nM
CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3cccc(C)c3)cc2)nc2cnccc12)C(N)=O CHEMBL5265849 IC50 61.0 nM
COc1ccc(Nc2ncnc3c2ccn3-c2ccc(C)c(C)c2)cn1 CHEMBL5287672 pIC50 63.1 nM
CC[C@@H](Nc1c(C#N)c(-c2ccc(Br)cc2)nc2cnccc12)C(=O)O CHEMBL5274835 IC50 66.0 nM
CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3cccc(Cl)c3)cc2)nc2cnccc12)C(N)=O CHEMBL5275703 IC50 74.0 nM
COc1ccc(Nc2ncnc3c2cnn3-c2ccc(C)c(C)c2)cc1Cl CHEMBL5269721 pIC50 79.43 nM
CS(=O)(=O)c1ccc(Nc2ncnc3sc(C#N)cc23)cc1 CHEMBL5410949 pIC50 79.43 nM
CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3ccc(F)cc3)cc2)nc2cnccc12)C(N)=O CHEMBL5288989 IC50 88.0 nM
CCOc1ccccc1-c1ccc(-c2nc3cnccc3c(N[C@H](CC)C(N)=O)c2C#N)cc1 CHEMBL5273777 IC50 89.0 nM
COc1ccc(Nc2ncnc3c2cnn3-c2ccc(C)cc2C)cc1Cl CHEMBL5285486 pIC50 100.0 nM
CN(C)S(=O)(=O)c1ccc(Nc2ncnc3sccc23)cc1 CHEMBL5438658 pIC50 100.0 nM
Cc1ncccc1-c1cc2ncnc(Nc3ccc(C4CC4)cc3)c2s1 CHEMBL5412191 pIC50 100.0 nM
Cc1ncccc1-c1cc2ncnc(Nc3ccc(N4CCCC4=O)cc3)c2s1 CHEMBL5394000 pIC50 100.0 nM
CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3ccccc3C)cc2)nc2cnccc12)C(N)=O CHEMBL5286700 IC50 110.0 nM
COc1ccc(Nc2ncnc3c2cnn3-c2ccc(C)cc2)cc1Cl CHEMBL1515038 pIC50 125.89 nM
COc1ccc(Nc2ncnc3c2CC(=O)N3c2ccc(C)c(C)c2)cc1Cl CHEMBL5267650 pIC50 125.89 nM
CNS(=O)(=O)c1ccc(Nc2ncnc3sccc23)cc1 CHEMBL5415390 pIC50 125.89 nM
CSc1ccc(Nc2ncnc3sc(-c4ccncc4C)cc23)cc1 CHEMBL5400154 pIC50 125.89 nM
CS(=O)(=O)Nc1ccc(-c2cncc(/C=C3\SC(=O)NC3=O)c2)cc1 CHEMBL4447308 IC50 130.0 nM
CC(=O)Nc1cccc(Nc2ncnc3c2ccn3-c2ccc(C)c(C)c2)c1 CHEMBL5286452 pIC50 158.49 nM
CSc1ccc(Nc2ncnc3sc(-c4c(C)noc4C)cc23)cc1 CHEMBL5424397 pIC50 158.49 nM
CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3ccccc3Cl)cc2)nc2cnccc12)C(N)=O CHEMBL5277327 IC50 160.0 nM
CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3cccc(F)c3)cc2)nc2cnccc12)C(N)=O CHEMBL5266303 IC50 180.0 nM
CCOc1ccccc1-c1ccc(-c2nc3cnccc3c(C[C@H](C)C(=O)O)c2C#N)cc1 CHEMBL5288398 IC50 200.0 nM
CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3cccc(OC)c3)cc2)nc2cnccc12)C(N)=O CHEMBL5282526 IC50 200.0 nM
CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3ccc(OC)cc3)cc2)nc2cnccc12)C(N)=O CHEMBL5289817 IC50 200.0 nM
CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O CHEMBL189963 Kd apparent 208.0 nM
CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3ccccc3NC)cc2)nc2cnccc12)C(N)=O CHEMBL5270656 IC50 240.0 nM
COc1ccc(Nc2ncnc3c2cnn3-c2ccc(Cl)cc2C)cc1Cl CHEMBL5284639 pIC50 251.19 nM
Cc1cc2c(Nc3ccc(NS(C)(=O)=O)cc3)ncnc2s1 CHEMBL5440409 pIC50 251.19 nM
O=S(=O)(c1ccc(Nc2ncnc3sccc23)cc1)C1CCCC1 CHEMBL5407912 pIC50 251.19 nM
CS(=O)(=O)c1ccc(Nc2ncnc3sc(Cl)cc23)cc1 CHEMBL5415988 pIC50 251.19 nM
CS(=O)(=O)c1ccc(Nc2ncnc3sc(-c4ccccc4)cc23)cc1 CHEMBL5422736 pIC50 251.19 nM
Cc1ncccc1-c1cc2c(Nc3ccc(C4CC4)cc3)ncnc2s1 CHEMBL5397757 pIC50 251.19 nM
CSc1ccc(Nc2ncnc3sc(-c4cccnc4C)cc23)cc1 CHEMBL5397186 pIC50 251.19 nM
CSc1ccc(Nc2ncnc3sc(-c4cccnc4Cl)cc23)cc1 CHEMBL5423670 pIC50 251.19 nM
CSc1ccc(Nc2ncnc3sc(-c4cnoc4)cc23)cc1 CHEMBL5400049 pIC50 251.19 nM
CS(=O)(=O)Nc1ccc(-c2cncc(/C=C3\SC(=N)NC3=O)c2)cc1 CHEMBL4436648 IC50 270.0 nM
CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3cccc(CO)c3)cc2)nc2cnccc12)C(N)=O CHEMBL5283036 IC50 284.0 nM
CCOc1ccccc1-c1ccc(-c2nc3cnccc3c(N[C@H](CC)C(=O)N(C)C)c2C#N)cc1 CHEMBL5270026 IC50 300.0 nM
CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3ccc(Cl)cc3)cc2)nc2cnccc12)C(N)=O CHEMBL5290821 IC50 300.0 nM
COc1ccc(Nc2ncnc3c2cnn3-c2ccc(C)c(C)c2)cn1 CHEMBL5291450 pIC50 316.23 nM
CS(=O)(=O)c1ccc(Nc2ncnc3sc(C(F)(F)F)cc23)cc1 CHEMBL5402331 pIC50 316.23 nM
Cc1ccc(Nc2ncnc3sc(-c4cccnc4C)cc23)cc1C CHEMBL5425693 pIC50 316.23 nM
CS(=O)(=O)c1ccc(Nc2ncnc3cc(-c4cccnc4Cl)sc23)cc1 CHEMBL5426348 pIC50 316.23 nM
CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3cccc(F)c3OC)cc2)nc2cnccc12)C(N)=O CHEMBL5283448 IC50 320.0 nM
COc1ccc(-n2ncc3c(Nc4ccc(OC)c(Cl)c4)ncnc32)cc1 CHEMBL5267048 pIC50 398.11 nM
O=S(=O)(c1ccc(Nc2ncnc3sccc23)cc1)C(F)(F)F CHEMBL5417246 pIC50 398.11 nM
O=S(=O)(c1ccc(Nc2ncnc3sccc23)cc1)N1CCCC1 CHEMBL5435467 pIC50 398.11 nM
CCOc1ccccc1-c1ccc(-c2nc3cnccc3c(N[C@H](CC)C(=O)NCC(F)F)c2C#N)cc1 CHEMBL5287137 IC50 490.0 nM
COc1ccc(Nc2ncnc3c2cnn3-c2cccc(C)c2)cc1Cl CHEMBL5274008 pIC50 501.19 nM
CS(=O)(=O)c1ccc(Nc2ncnc3sccc23)cc1 CHEMBL5413585 pIC50 501.19 nM
CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3ccccc3CO)cc2)nc2cnccc12)C(N)=O CHEMBL5282865 IC50 520.0 nM
CCOc1ccccc1-c1ccc(-c2nc3cnccc3c(N[C@@H]3CCOC3=O)c2C#N)cc1 CHEMBL5270414 IC50 560.0 nM
CC[C@@H](Nc1c(C#N)c(-c2ccc(Br)cc2)nc2cnccc12)C(N)=O CHEMBL5291274 IC50 610.0 nM
CCOc1ccccc1-c1ccc(-c2nc3cnccc3c(N)c2C#N)cc1 CHEMBL5266064 IC50 630.0 nM
COc1ccc(Nc2ncnc3c2ccn3-c2cccc(N)c2)cc1 CHEMBL5288084 pIC50 630.96 nM
O=S(=O)(c1ccc(Nc2ncnc3sccc23)cc1)N1CCC(F)(F)C1 CHEMBL5422896 pIC50 630.96 nM
Cc1cnccc1-c1cc2c(Nc3ccc(S(C)(=O)=O)cc3)ncnc2s1 CHEMBL5405402 pIC50 630.96 nM
CS(=O)(=O)c1ccc(Nc2ncnc3sc(-c4cccnc4Cl)cc23)cc1 CHEMBL5427550 pIC50 630.96 nM
Cc1ccc(Nc2ncnc3sc(-c4cccnc4C)cc23)cc1 CHEMBL5422646 pIC50 630.96 nM
CCc1ccc(Nc2ncnc3sc(-c4cccnc4C)cc23)cc1 CHEMBL5398260 pIC50 630.96 nM
COc1ccc(Nc2ncnc3sc(-c4ccncc4C)cc23)cc1 CHEMBL5427841 pIC50 630.96 nM
Cc1ncccc1-c1cc2ncnc(Nc3ccc(S(F)(F)(F)(F)F)cc3)c2s1 CHEMBL5425305 pIC50 630.96 nM
CCCCC(Nc1c(C#N)c(-c2ccc(-c3ccccc3OCC)cc2)nc2cnccc12)C(N)=O CHEMBL5278249 IC50 650.0 nM
CCOc1ccccc1-c1ccc(-c2nc3cnccc3c(N[C@H](CC(C)C)C(N)=O)c2C#N)cc1 CHEMBL5274662 IC50 650.0 nM
CS(=O)(=O)Nc1ccc(-c2cc(/C=C3\SC(=N)NC3=O)cnc2N)cc1 CHEMBL4454033 IC50 660.0 nM
CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3ncccc3C)cc2)nc2cnccc12)C(N)=O CHEMBL5281763 IC50 660.0 nM
CCOc1ccccc1-c1ccc(-c2nc3cnccc3c(NC(COC)C(N)=O)c2C#N)cc1 CHEMBL5267768 IC50 740.0 nM
CCOc1ccccc1-c1ccc(-c2nc3cnccc3c(NC(C(N)=O)C3CC3)c2C#N)cc1 CHEMBL5266252 IC50 820.0 nM
CCOc1ccccc1-c1ccc(-c2nc3cnccc3c(NC(CC)CNS(=O)(=O)C3CC3)c2C#N)cc1 CHEMBL5285706 IC50 910.0 nM
CN(C)C/C=C/C(=O)Nc1ccc(C(=O)Nc2cccc(Nc3cc(-c4c[nH]c5ccccc45)ncn3)c2)cc1 CHEMBL4446338 IC50 950.0 nM
CN(C)C/C=C/C(=O)NC1CCN(C(=O)Cc2cccc(Nc3cc(-c4cnc5[nH]ccc5c4)ncn3)c2)CC1 CHEMBL4449493 IC50 1000.0 nM
COc1cc(/C=C(\C#N)C(=O)c2ccc(O)c(O)c2)cc(I)c1O CHEMBL1257003 IC50 1000.0 nM
CC(=O)Nc1ccc(Nc2ncnc3c2ccn3-c2ccc(C)c(C)c2)cc1 CHEMBL5281250 pIC50 1000.0 nM
Cc1ccncc1-c1cc2c(Nc3ccc(S(C)(=O)=O)cc3)ncnc2s1 CHEMBL5399468 pIC50 1000.0 nM
Cc1ncccc1-c1cc2c(Nc3ccc(S(C)(=O)=O)cc3)ncnc2s1 CHEMBL5405966 pIC50 1000.0 nM