CS(=O)(=O)Nc1ccc(-c2cc(/C=C3\SC(=N)NC3=O)cnc2N)cc1 CHEMBL4454033 Kd 0.023 nM
CS(=O)(=O)Nc1ccc(-c2cncc(/C=C3\SC(=N)NC3=O)c2)cc1 CHEMBL4436648 Kd 1.6 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 3.0 nM
CS(=O)(=O)Nc1ccc(-c2cncc(-c3cccc4[nH]ccc34)c2)cc1 CHEMBL4455633 Kd 3.4 nM
CN(C)C/C=C/C(=O)Nc1ccc(C(=O)Nc2cccc(Nc3cc(-c4c[nH]c5ccccc45)ncn3)c2)cc1 CHEMBL4446338 Kd 4.8 nM
Cc1cc2c(Nc3ccc(NS(C)(=O)=O)cc3)ncnc2s1 CHEMBL5440409 Kd 7.1 nM
CSc1ccc(Nc2ncnc3cc(-c4cccnc4Cl)sc23)cc1 CHEMBL5420914 pIC50 7.943 nM
Cc1ncccc1-c1cc2ncnc(Nc3ccc(N4CCCC4=O)cc3)c2s1 CHEMBL5394000 pIC50 7.943 nM
Cc1cnccc1-c1cc2c(Nc3ccc(S(C)(=O)=O)cc3)ncnc2s1 CHEMBL5405402 pIC50 12.59 nM
Cc1ccncc1-c1cc2c(Nc3ccc(S(C)(=O)=O)cc3)ncnc2s1 CHEMBL5399468 pIC50 12.59 nM
CS(=O)(=O)c1ccc(Nc2ncnc3sc(-c4cccnc4Cl)cc23)cc1 CHEMBL5427550 pIC50 12.59 nM
CS(=O)(=O)c1ccc(Nc2ncnc3cc(-c4cccnc4Cl)sc23)cc1 CHEMBL5426348 pIC50 12.59 nM
CS(=O)(=O)c1ccc(Nc2ncnc3sc(-c4cn[nH]c4)cc23)cc1 CHEMBL5425953 pIC50 15.85 nM
CS(=O)(=O)c1ccc(Nc2ncnc3sc(-c4ccncc4)cc23)cc1 CHEMBL5431778 pIC50 19.95 nM
Cc1ncccc1-c1cc2c(Nc3ccc(S(C)(=O)=O)cc3)ncnc2s1 CHEMBL5405966 pIC50 19.95 nM
CSc1ccc(Nc2ncnc3sc(-c4ccncc4C)cc23)cc1 CHEMBL5400154 pIC50 19.95 nM
CSc1ccc(Nc2ncnc3sc(-c4cccnc4Cl)cc23)cc1 CHEMBL5423670 pIC50 19.95 nM
CSc1ccc(Nc2ncnc3sc(-c4c(C)noc4C)cc23)cc1 CHEMBL5424397 pIC50 25.12 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 28.0 nM
CS(=O)(=O)c1ccc(Nc2ncnc3sc(-c4cccnc4)cc23)cc1 CHEMBL5413364 pIC50 31.62 nM
COc1cnccc1-c1cc2c(Nc3ccc(S(C)(=O)=O)cc3)ncnc2s1 CHEMBL5415354 pIC50 31.62 nM
CS(=O)(=O)c1ccc(Nc2ncnc3sc(-c4cccnc4F)cc23)cc1 CHEMBL5399847 pIC50 31.62 nM
CN1C(=O)c2sccc2N(C)c2nc(Nc3ccc(S(N)(=O)=O)cc3)ncc21 CHEMBL4554938 Kd 34.0 nM
CC(=O)Nc1ccc(C(=O)Nc2cccc(Nc3cc(-c4c[nH]c5ccccc45)ncn3)c2)cc1 CHEMBL5423303 Kd 34.0 nM
CS(=O)(=O)c1ccc(Nc2ncnc3sc(-c4ccccc4)cc23)cc1 CHEMBL5422736 pIC50 39.81 nM
Cn1cc(-c2cc3c(Nc4ccc(S(C)(=O)=O)cc4)ncnc3s2)cn1 CHEMBL5399032 pIC50 39.81 nM
CSc1ccc(Nc2ncnc3sc(-c4cnoc4)cc23)cc1 CHEMBL5400049 pIC50 39.81 nM
CSc1ccc(Nc2ncnc3sc(-c4cccnc4C)cc23)cc1 CHEMBL5397186 pIC50 50.12 nM
Cc1csc2ncnc(Nc3ccc(S(C)(=O)=O)cc3)c12 CHEMBL5428289 pIC50 50.12 nM
CS(=O)(=O)c1ccc(Nc2ncnc3scc(Cl)c23)cc1 CHEMBL5402305 pIC50 50.12 nM
CN(C(=O)c1csc2ncnc(Nc3ccc(S(C)(=O)=O)cc3)c12)c1ccccc1 CHEMBL5436163 pIC50 50.12 nM
CS(=O)(=O)c1ccc(Nc2ncnc3ccsc23)cc1 CHEMBL5415385 pIC50 50.12 nM
Cc1ncccc1-c1cc2ncnc(Nc3ccc(C4CC4)cc3)c2s1 CHEMBL5412191 pIC50 50.12 nM
CS(=O)(=O)c1ccc(Nc2ncnc3sc(-c4ccnc(Cl)c4)cc23)cc1 CHEMBL5428618 pIC50 63.1 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCNC(=O)c2ccc(C(=O)Nc3cccc(Nc4cc(-c5c[nH]c6ccccc56)ncn4)c3)cc2)C(C)(C)C)cc1 CHEMBL5441057 Kd 65.0 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 Kd apparent 67.0 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCNC(=O)c2ccc(C(=O)Nc3cccc(Nc4cc(-c5c[nH]c6ccccc56)ncn4)c3)cc2)C(C)(C)C)cc1 CHEMBL5426728 Kd 67.0 nM
CC(C)c1ccccc1-c1nc(NCc2ccccn2)c2c(ccn2C)n1 CHEMBL5085734 Kd 68.0 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCNC(=O)c2ccc(C(=O)Nc3cccc(Nc4cc(-c5c[nH]c6ccccc56)ncn4)c3)cc2)C(C)(C)C)cc1 CHEMBL5406257 Kd 77.0 nM
Cc1cc2c(Nc3ccc(S(C)(=O)=O)cc3)ncnc2s1 CHEMBL5410975 pIC50 79.43 nM
CS(=O)(=O)c1ccc(Nc2ncnc3sc(-c4ccncc4F)cc23)cc1 CHEMBL5403647 pIC50 100.0 nM
Cc1ncccc1-c1cc2c(Nc3ccc(C4CC4)cc3)ncnc2s1 CHEMBL5397757 pIC50 100.0 nM
CS(=O)(=O)c1ccc(Nc2ncnc3scc(C4CC4)c23)cc1 CHEMBL5413329 pIC50 100.0 nM
Cc1ncccc1-c1cc2ncnc(Nc3ccc(S(F)(F)(F)(F)F)cc3)c2s1 CHEMBL5425305 pIC50 100.0 nM
CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc2N1C1CCCC1 CHEMBL513909 Kd 110.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 120.0 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCC(=O)Nc2ccc(C(=O)Nc3cccc(Nc4cc(-c5c[nH]c6ccccc56)ncn4)c3)cc2)C(C)(C)C)cc1 CHEMBL5428687 Kd 150.0 nM
Cc1sc2ncnc(Nc3ccc(S(C)(=O)=O)cc3)c2c1C CHEMBL5411356 pIC50 199.53 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCC(=O)Nc2ccc(C(=O)Nc3cccc(Nc4cc(-c5c[nH]c6ccccc56)ncn4)c3)cc2)C(C)(C)C)cc1 CHEMBL5419800 Kd 220.0 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 230.0 nM
O=C(COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCOCCOCCC(=O)Nc1cccc(Nc2cc(-c3c[nH]c4ccccc34)ncn2)c1 CHEMBL5436468 Kd 230.0 nM
O=C(COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCOCCOCCOCCOCCC(=O)Nc1cccc(Nc2cc(-c3c[nH]c4ccccc34)ncn2)c1 CHEMBL5418854 Kd 230.0 nM
CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(-c2scnc2C(=O)NCCCCCNC(=O)c2ccc(C(=O)Nc3cccc(Nc4cc(-c5c[nH]c6ccccc56)ncn4)c3)cc2)cc1)C(C)(C)C CHEMBL5408017 Kd 270.0 nM
O=C(COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCOCCOCCOCCC(=O)Nc1cccc(Nc2cc(-c3c[nH]c4ccccc34)ncn2)c1 CHEMBL5436645 Kd 270.0 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCC(=O)Nc2ccc(C(=O)Nc3cccc(Nc4cc(-c5c[nH]c6ccccc56)ncn4)c3)cc2)C(C)(C)C)cc1 CHEMBL5418550 Kd 270.0 nM
Cc1nc(CNc2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)cs1 CHEMBL1435542 Kd 280.0 nM
Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O CHEMBL477772 Kd 280.0 nM
CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(-c2scnc2C)cc1)C(C)(C)SCCCCCNC(=O)c1ccc(C(=O)Nc2cccc(Nc3cc(-c4c[nH]c5ccccc45)ncn3)c2)cc1 CHEMBL5406416 Kd 300.0 nM
c1nc(NCC2CCOC2)c2cc(-c3ccc4c(c3)OCO4)ccc2n1 CHEMBL1436585 Kd 310.0 nM
CS(=O)(=O)c1ccc(Nc2ncnc3sccc23)cc1 CHEMBL5413585 pIC50 316.23 nM
Cn1cc(-c2ccc3nnc(C(F)(F)c4ccc5ncccc5c4)n3n2)cn1 CHEMBL2133806 Kd apparent 320.0 nM
O=C(COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCCCCCCCC(=O)Nc1ccc(C(=O)Nc2cccc(Nc3cc(-c4c[nH]c5ccccc45)ncn3)c2)cc1 CHEMBL5397185 Kd 330.0 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCC(=O)Nc2ccc(C(=O)Nc3cccc(Nc4cc(-c5c[nH]c6ccccc56)ncn4)c3)cc2)C(C)(C)C)cc1 CHEMBL5396741 Kd 330.0 nM
O=C1NC(=O)/C(=C/c2ccc3nccc(-c4ccncc4)c3c2)S1 CHEMBL3544966 Kd apparent 331.0 nM
O=C1CCC(N2C(=O)c3cccc(NCCCCCC(=O)Nc4ccc(C(=O)Nc5cccc(Nc6cc(-c7c[nH]c8ccccc78)ncn6)c5)cc4)c3C2=O)C(=O)N1 CHEMBL5413905 Kd 340.0 nM
Cc1nc(CN(C)c2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)cs1 CHEMBL1474834 Kd 360.0 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL941 Kd 380.0 nM
CCc1ccc(Nc2ncnc3sc(-c4cccnc4C)cc23)cc1 CHEMBL5398260 pIC50 398.11 nM
O=C1CCC(N2C(=O)c3cccc(NCCOCCOCCOCCC(=O)Nc4ccc(C(=O)Nc5cccc(Nc6cc(-c7c[nH]c8ccccc78)ncn6)c5)cc4)c3C2=O)C(=O)N1 CHEMBL5427799 Kd 420.0 nM
CCc1ccc(/N=C2\S/C(=C\c3ccnc(Nc4ccc(C(=O)O)cn4)c3)C(=O)N2C)cc1 CHEMBL3921246 Kd 480.0 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CC(=O)Nc2ccc(C(=O)Nc3cccc(Nc4cc(-c5c[nH]c6ccccc56)ncn4)c3)cc2)C(C)(C)C)cc1 CHEMBL5400791 Kd 490.0 nM
Cc1ncccc1-c1cc2ncnc(Nc3ccc4ncoc4c3)c2s1 CHEMBL5396007 pIC50 501.19 nM
CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)c1ccc(-c2scnc2C)cc1OCCCCCNC(=O)c1ccc(C(=O)Nc2cccc(Nc3cc(-c4c[nH]c5ccccc45)ncn3)c2)cc1)C(C)(C)C CHEMBL5421648 Kd 510.0 nM
Nc1nc(N)c2nc(-c3cccc(O)c3)c(-c3cccc(O)c3)nc2n1 CHEMBL230011 Kd 530.0 nM
O=C1CCC(N2C(=O)c3cccc(C#CCCCCCC(=O)Nc4cccc(Nc5cc(-c6c[nH]c7ccccc67)ncn5)c4)c3C2=O)C(=O)N1 CHEMBL5432791 Kd 570.0 nM
Oc1cccc(-c2nc(N3CCOCC3)c3oc4ncccc4c3n2)c1 CHEMBL573339 Kd 620.0 nM
Cn1nnnc1Sc1ncnc2scc(-c3cccc(S(C)(=O)=O)c3)c12 CHEMBL1378392 Kd 630.0 nM
CC(C)c1ccccc1-c1nc(NCc2ccccn2)c2ccccc2n1 CHEMBL5083265 pIC50 630.96 nM
FC(F)(F)c1ccccc1-c1nc(NCc2ccccn2)c2cccnc2n1 CHEMBL5077987 pIC50 630.96 nM
COc1ccc(Nc2ncnc3sc(-c4ccncc4C)cc23)cc1 CHEMBL5427841 pIC50 630.96 nM
O=C(COc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)NCCCCCCCCC(=O)Nc1cccc(Nc2cc(-c3c[nH]c4ccccc34)ncn2)c1 CHEMBL5440896 Kd 670.0 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 780.0 nM
CC(C)c1ccccc1-c1nc(NCc2ccccn2)c2cccnc2n1 CHEMBL5077419 pIC50 794.33 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1 CHEMBL428690 Kd 870.0 nM
O=C1CCC(N2C(=O)c3cccc(C#CCCCC(=O)Nc4cccc(Nc5cc(-c6c[nH]c7ccccc67)ncn5)c4)c3C2=O)C(=O)N1 CHEMBL5436714 Kd 870.0 nM
Cn1nnnc1Sc1ncnc2scc(I)c12 CHEMBL1554143 Kd 890.0 nM
C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1 CHEMBL553 Kd 1000.0 nM
CS(=O)(=O)c1cccc(-c2csc3ncnc(Sc4nccs4)c23)c1 CHEMBL3729099 Kd 1000.0 nM
Cc1csc(Sc2ncnc3scc(-c4cccc(S(C)(=O)=O)c4)c23)n1 CHEMBL3727398 Kd 1000.0 nM
FC(F)(F)c1ccccc1-c1nc(NCc2cccs2)c2ccccc2n1 CHEMBL1529478 IC50 1000.0 nM