CCN(CC)CCN(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL10921 IC50 0.006 nM
CCN(CC)CCN(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)Cn1c(SCc2ccc(F)cc2)nc(=O)c2c1CCC2 CHEMBL204021 IC50 0.035 nM
CCN(CC)CCN(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)Cn1c(SCc2ccc(F)cc2)nc(=O)c2c1CCCC2 CHEMBL10441 IC50 0.1 nM
Cn1cc(Cc2cn(CC(=O)N(CC(=O)N3CCOCC3)Cc3ccc(-c4ccc(C(F)(F)F)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL89451 IC50 0.1 nM
CCCCCCCCCCNC(=O)CCCn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL87729 IC50 0.1 nM
CCN(CCO)CCN(Cc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL407553 IC50 0.12 nM
CCNCCN(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL87100 IC50 0.12 nM
CN(C)CCN(C)Cc1nnc(Cn2c(SCc3ccc(F)cc3)nc(=O)c3c2CCC3)n1Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1 CHEMBL2380965 IC50 0.14 nM
Cn1cc(Cc2cn(CC(=O)N(CCN3CCCCC3)Cc3ccc(-c4ccc(C(F)(F)F)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL314768 IC50 0.17 nM
COc1ncc(Cc2cn(CC(=O)N(C)Cc3ccc(-c4ccc(Cl)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL79555 IC50 0.2 nM
CN(C)C(=O)CN(Cc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL85080 IC50 0.2 nM
COc1ncc(Cc2cn(CC(=O)N(CC(=O)N(C)C)Cc3ccc(-c4ccc(Cl)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL84894 IC50 0.2 nM
COc1ncc(Cc2cn(CC(=O)N(CCO)Cc3ccc(-c4ccc(Cl)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL87787 IC50 0.2 nM
CCNCCN(Cc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL87156 IC50 0.2 nM
CC(C)N(CCN(Cc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1)C(C)C CHEMBL315504 IC50 0.2 nM
COc1ncc(Cc2cn(CC(=O)N(CCN(C)C)Cc3ccc(-c4ccc(Cl)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL314954 IC50 0.2 nM
CN(Cc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)Cn1cc(Cc2cnc(N3CCNCC3)nc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL348243 IC50 0.2 nM
COc1ncc(Cc2cn(CC(=O)N(C)Cc3ccc(-c4ccc(C(F)(F)F)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL150446 IC50 0.2 nM
CN(CCN1CCCC1)Cc1nnc(Cn2c(SCc3ccc(F)cc3)nc(=O)c3c2CCC3)n1Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1 CHEMBL2380967 IC50 0.23 nM
CCN(CC)CCN(C)C(C)c1nnc(Cn2c(SCc3ccc(F)cc3)nc(=O)c3c2CCC3)n1Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1 CHEMBL2380954 IC50 0.24 nM
CCN(CC)CCN(Cc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)Cn1c(SCc2ccc(F)cc2)nc(=O)c2c1CCCC2 CHEMBL10501 IC50 0.25 nM
COCCN1CCC(N(Cc2ccc(-c3ccc(C(F)(F)F)cc3)cc2)C(=O)Cn2c(SCc3cccc(F)c3F)cc(=O)c3ccccc32)CC1 CHEMBL2104981 pIC50 0.2512 nM
Cn1cc(Cc2cn(CC(=O)N(CCN3CCCCC3)Cc3ccc(-c4ccc(Cl)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL85179 IC50 0.3 nM
CN(C)C(=O)CN(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL328527 IC50 0.3 nM
CCCCCCCCCCCCNC(=O)Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL85885 IC50 0.3 nM
CCN(CC)CCCN(Cc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL315766 IC50 0.35 nM
CCN(CC)CCN(CC12CC(c3ccc(C(F)(F)F)cc3)(C1)C2)C(=O)Cn1c(SCc2ccc(F)cc2)nc(=O)c2c1CCC2 CHEMBL3967156 pIC50 0.3981 nM
CCc1cn(CC(=O)N(CCN(CC)CC)Cc2ccc(-c3ccc(C(F)(F)F)cc3)cc2)c(SCc2ccc(F)cc2)nc1=O CHEMBL10604 IC50 0.4 nM
CCN(CC)CCN(Cc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)Cn1c(SCc2ccc(F)cc2)nc(=O)c2c1CCC2 CHEMBL10663 IC50 0.4 nM
CCCCCCCC/C=C/CCCCCCCCNC(=O)CCCn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL293933 IC50 0.4 nM
CCCCCCCC/C=C\CCCCCCCCNC(=O)CCCn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL2111560 IC50 0.4 nM
CCCCCCCCNC(=O)CCCn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL421165 IC50 0.4 nM
CCN(CC)CCCCc1nnc(Cn2c(SCc3ccc(F)cc3)nc(=O)c3c2CCC3)n1Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1 CHEMBL2380957 IC50 0.46 nM
CCN(CC)CCN(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)Cn1c(SCc2ccc(F)cc2)nc(=O)c(C)c1C CHEMBL10759 IC50 0.5 nM
CN(C)CCCN(Cc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL87355 IC50 0.5 nM
Cn1cc(Cc2cn(CC(=O)N(CCN(CCO)CCO)Cc3ccc(-c4ccc(Cl)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL262376 IC50 0.5 nM
COc1ncc(Cc2cn(CC(=O)NCc3ccc(-c4ccc(Cl)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL358483 IC50 0.5 nM
CCn1cc(Cc2cn(CC(=O)N(C)Cc3ccc(-c4ccc(Cl)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cnc1=O CHEMBL155227 IC50 0.5 nM
CN(Cc1ccc(-c2ccc(Br)cc2)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL153546 IC50 0.5 nM
CN(C)CCCN(C)Cc1nnc(Cn2c(SCc3ccc(F)cc3)nc(=O)c3c2CCC3)n1Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1 CHEMBL2380968 IC50 0.55 nM
Cn1cc(Cc2cn(CC(=O)N(CCO)Cc3ccc(-c4ccc(C(F)(F)F)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL329158 IC50 0.6 nM
Cn1cc(Cc2cn(CC(=O)N(CCO)Cc3ccc(-c4ccc(Cl)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL276856 IC50 0.6 nM
CN(C)CCN(Cc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL415274 IC50 0.6 nM
COc1ncc(Cc2cn(CC(=O)N(C)Cc3ccc(-c4ccc(F)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL153164 IC50 0.6 nM
CN(CCN1CCCCC1)Cc1nnc(Cn2c(SCc3ccc(F)cc3)nc(=O)c3c2CCC3)n1Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1 CHEMBL2380966 IC50 0.67 nM
CCN(CC)CCN(Cc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL86932 IC50 0.7 nM
CN(C)CCN(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL87792 IC50 0.7 nM
CN(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL153752 IC50 0.7 nM
CCCc1cn(CC(=O)N(CCN(CC)CC)Cc2ccc(-c3ccc(C(F)(F)F)cc3)cc2)c(SCc2ccc(F)cc2)nc1=O CHEMBL274551 IC50 0.8 nM
CCN(CC)CCN(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)Cn1cc(SC)c(=O)nc1SCc1ccc(F)cc1 CHEMBL10600 IC50 0.8 nM
CCN(CC)CCN(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)Cn1cc([S+](C)[O-])c(=O)nc1SCc1ccc(F)cc1 CHEMBL275128 IC50 0.8 nM
Cn1cc(Cc2cn(CC(=O)N(CCN3CCCC3)Cc3ccc(-c4ccc(Cl)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL405981 IC50 0.8 nM
CN(Cc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)Cn1cc(Cc2cnc(N(C)C)nc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL151095 IC50 0.8 nM
CC(c1nnc(Cn2c(SCc3ccc(F)cc3)nc(=O)c3c2CCC3)n1Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)N(C)CCN(C)C CHEMBL2380955 IC50 0.81 nM
O=c1nc(SCc2ccc(F)cc2)n(Cc2nnc(CCCN3CCCC3)n2Cc2ccc(-c3ccc(C(F)(F)F)cc3)cc2)c2c1CCC2 CHEMBL2380959 IC50 0.86 nM
CC(c1nnc(Cn2c(SCc3ccc(F)cc3)nc(=O)c3c2CCC3)n1Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)N(C)CCCN(C)C CHEMBL2380956 IC50 0.89 nM
Cc1ccc(-c2ccc(CN(C)C(=O)Cn3cc(Cc4cnn(C)c4)c(=O)nc3SCc3ccc(F)cc3)cc2)cc1 CHEMBL153142 IC50 0.9 nM
CCN(CC)CCN(C)Cc1nnc(Cn2c(SCc3ccc(F)cc3)nc(=O)c3c2CCC3)n1Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1 CHEMBL2380963 IC50 0.91 nM
O=c1nc(SCc2ccc(F)cc2)n(Cc2nnc(CCCN3CCCCC3)n2Cc2ccc(-c3ccc(C(F)(F)F)cc3)cc2)c2c1CCC2 CHEMBL2380960 IC50 0.95 nM
CCN(CC)CCCc1nnc(Cn2c(SCc3ccc(F)cc3)nc(=O)c3c2CCC3)n1Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1 CHEMBL2380958 IC50 0.96 nM
CCN(CC)CCN(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)Cn1cc(CCNS(C)(=O)=O)c(=O)nc1SCc1ccc(F)cc1 CHEMBL10352 IC50 1.0 nM
CCN(CC)CCN(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)Cn1cc(C)c(=O)nc1SCc1ccc(F)cc1 CHEMBL10532 IC50 1.0 nM
CCN(CC)CCN(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)Cn1cc(Br)c(=O)nc1SCc1ccc(F)cc1 CHEMBL10271 IC50 1.0 nM
CCc1cn(CC(=O)N(CCN(CC)CC)Cc2ccc(-c3ccc(Cl)cc3)cc2)c(SCc2ccc(F)cc2)nc1=O CHEMBL273503 IC50 1.0 nM
CCCCCCCCCCCCN(C)C(=O)Cn1cc(Cc2cnc(OC)nc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL57713 IC50 1.0 nM
Cn1cc(Cc2cn(CC(=O)N(CCCN3CCCC3)Cc3ccc(-c4ccc(Cl)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL89234 IC50 1.0 nM
Cn1cc(Cc2cn(CC(=O)N(CC(=O)O)Cc3ccc(-c4ccc(C(F)(F)F)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL89750 IC50 1.0 nM
CN(Cc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL328023 IC50 1.0 nM
COc1ncc(Cc2cn(CC(=O)N(CC(=O)O)Cc3ccc(-c4ccc(Cl)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL315528 IC50 1.0 nM
CN(C)CCCN(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL86367 IC50 1.0 nM
CN(Cc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)Cn1cc(Cc2cnc(O)nc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL348030 IC50 1.0 nM
CN(Cc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)Cn1cc(Cc2cnc(N3CCOCC3)nc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL358052 IC50 1.0 nM
CCCCCCCCCCCCN(C)C(=O)Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL87741 IC50 1.0 nM
CCCCCCCC/C=C\CCCCCCCCNC(=O)Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL2111561 IC50 1.0 nM
CCOC(=O)CN(C)c1cc(OCc2cc(F)c(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)nc(=O)n1C CHEMBL3792774 IC50 1.1 nM
COC1CCN(c2cc(OCc3cc(F)c(Oc4ccc(Cl)c(C(F)(F)F)c4)c(F)c3)nc(=O)n2C)CC1 CHEMBL3792873 IC50 1.1 nM
COCCN(C)c1cc(OCc2cc(F)c(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)nc(=O)n1C CHEMBL3792756 IC50 1.2 nM
Cn1cc(Cc2cn(CC(=O)N(CCN3CCOCC3)Cc3ccc(-c4ccc(Cl)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL328064 IC50 1.4 nM
COC(CO)Cn1ccc(Nc2cc(-c3ccccc3C)c(C)cc2OCCN)n1 CHEMBL3818650 IC50 1.4 nM
CCN(CC)CCN(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)Cn1cc(CO)c(=O)nc1SCc1ccc(F)cc1 CHEMBL165840 IC50 1.5 nM
CCN(Cc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL316435 IC50 1.5 nM
CN(Cc1ccc(-c2cccc(Cl)c2)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL151061 IC50 1.6 nM
CN(Cc1ccc(-c2ccccc2Cl)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL153579 IC50 1.6 nM
Cn1cc(Cc2cn(CC(=O)NCc3ccc(-c4ccc(Cl)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL152387 IC50 1.6 nM
CN(C)[C@@H]1CCN(Cc2nnc(Cn3c(SCc4ccc(F)cc4)nc(=O)c4c3CCC4)n2Cc2ccc(-c3ccc(C(F)(F)F)cc3)cc2)C1 CHEMBL2380859 IC50 1.6 nM
Cn1c(N2CCOCC2)cc(OCc2cc(F)c(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)nc1=O CHEMBL3794023 IC50 1.6 nM
CN1CCN(c2ncc(Cc3cn(CC(=O)N(C)Cc4ccc(-c5ccc(Cl)cc5)cc4)c(SCc4ccc(F)cc4)nc3=O)cn2)CC1 CHEMBL149644 IC50 1.7 nM
Cn1c(N2CCS(=O)(=O)CC2)cc(OCc2cc(F)c(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)nc1=O CHEMBL3792924 IC50 1.7 nM
CCN(CC)CCN(C)Cc1cnc(Cn2c(SCc3ccc(F)cc3)nc(=O)c3c2CCC3)n1Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1 CHEMBL2380952 IC50 1.72 nM
Cn1c(N2CCN(C3CC3)CC2)cc(OCc2cc(F)c(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)nc1=O CHEMBL3792761 IC50 1.8 nM
Cn1c(N2CCSCC2)cc(OCc2cc(F)c(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)nc1=O CHEMBL3793007 IC50 1.8 nM
Cn1c(N2CCOCC2)cc(OCc2ccc(Oc3ccc(Cl)c(C(F)(F)F)c3)cc2)nc1=O CHEMBL3794575 IC50 1.9 nM
CCN(CC)CCN(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)Cn1cc(CCO)c(=O)nc1SCc1ccc(F)cc1 CHEMBL10502 IC50 2.0 nM
COc1ncc(Cc2cn(CCCC(=O)N3CCN(c4ccc(C(F)(F)F)cc4)CC3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL294693 IC50 2.0 nM
COc1ncc(Cc2cn(CCCC(=O)N3CCN(c4ccc(Cl)c(Cl)c4)CC3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL301015 IC50 2.0 nM
Cn1cc(Cc2cn(CC(=O)N(CCN)Cc3ccc(-c4ccc(Cl)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL87071 IC50 2.0 nM
CN1CCN(CCCN(Cc2ccc(-c3ccc(Cl)cc3)cc2)C(=O)Cn2cc(Cc3cnn(C)c3)c(=O)nc2SCc2ccc(F)cc2)CC1 CHEMBL327705 IC50 2.0 nM
O=C(Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1)NCCCCCCc1ccc(F)cc1 CHEMBL83522 IC50 2.0 nM
CCCCCCCNC(=O)CCCn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL82956 IC50 2.0 nM
CCCCCCCC/C=C/CCCCCCCCNC(=O)Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL87882 IC50 2.0 nM
Cn1c(N2CCC(F)CC2)cc(OCc2cc(F)c(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)nc1=O CHEMBL3794220 IC50 2.2 nM
Cn1c(N2CCOCC2)cc(OCc2ccc(Oc3ccc(Cl)c(C(F)(F)F)c3)c(C#N)c2)nc1=O CHEMBL3793506 IC50 2.2 nM
Fc1cc(COc2ccn3c(-c4cncnc4)cnc3n2)cc(F)c1Oc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL3634553 IC50 2.3 nM
COC(CO)Cc1csc(Nc2cc(-c3ccccc3C)c(C)cc2OCCN)n1 CHEMBL3817896 IC50 2.4 nM
CN(Cc1ccc(-c2ccc(C#N)cc2)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL346439 IC50 2.6 nM
Cc1cc(OCc2cc(F)c(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)nc(=O)n1C CHEMBL3792835 IC50 2.6 nM
CN(Cc1ccc(-c2ccc(F)cc2)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL150447 IC50 2.7 nM
Cn1c(N2CCOCC2)cc(OCc2ccc(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)nc1=O CHEMBL3794054 IC50 2.7 nM
N#Cc1cc(COc2ccn3c(-c4cncnc4)cnc3n2)ccc1Oc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL3634550 IC50 2.9 nM
CCN(CC)CCN(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)Cn1cc(Cl)c(=O)nc1SCc1ccc(F)cc1 CHEMBL10769 IC50 3.0 nM
CCN(CC)CCN(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)Cn1c(C)cc(=O)nc1SCc1ccc(F)cc1 CHEMBL268764 IC50 3.0 nM
Cn1cc(Cc2cn(CCCC(=O)N3CCN(c4ccc(Cl)cc4)CC3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL57132 IC50 3.0 nM
COc1ncc(Cc2cn(CCCC(=O)NCc3ccc(-c4ccc(F)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL152138 IC50 3.0 nM
CCCCCCCN(C)C(=O)CCCn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL87268 IC50 3.0 nM
Cc1c(F)cccc1NC(=O)c1cc(O)c2cccc(NS(C)(=O)=O)c2n1 CHEMBL2335784 IC50 3.0 nM
Cc1cc(F)ccc1NC(=O)c1cc(O)c2cccc(NS(C)(=O)=O)c2n1 CHEMBL2335783 IC50 3.0 nM
O=c1nc(OCCc2ccc(Oc3ccc(Cl)c(C(F)(F)F)c3)cc2)[nH]cc1Cc1cncnc1 CHEMBL3634561 IC50 3.4 nM
CN1CCN(c2cc(OCc3cc(F)c(Oc4ccc(Cl)c(C(F)(F)F)c4)c(F)c3)nc(=O)n2C)CC1 CHEMBL3792672 IC50 3.5 nM
COc1cc(C)c(-c2ccccc2C)cc1Nc1nc(CC(CO)OC)cs1 CHEMBL3819600 IC50 3.6 nM
Fc1cc(COc2ccn3c(-c4cncnc4)cnc3n2)ccc1Oc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL3634549 IC50 3.7 nM
COc1cc(OCc2cc(F)c(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)nc(=O)n1C CHEMBL3792670 IC50 3.7 nM
CN(C)c1cc(OCc2cc(F)c(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)nc(=O)n1C CHEMBL3792717 IC50 3.9 nM
O=C(Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1)NCc1ccc(-c2ccccc2)cc1 CHEMBL153681 IC50 4.0 nM
COc1ncc(Cc2cn(CCCC(=O)NCc3ccc(-c4ccc(Cl)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL154817 IC50 4.0 nM
COc1ncc(Cc2cn(CCCC(=O)NCc3ccc(-c4ccccc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL152705 IC50 4.0 nM
Cn1cc(Cc2cn(CCCC(=O)NCc3ccc(-c4ccc(F)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL150822 IC50 4.0 nM
CCCCCCCCCCCCCCCCCCNC(=O)CCCn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL315274 IC50 4.0 nM
CS(=O)(=O)Nc1cccc2c(O)cc(C(=O)Nc3ccc(F)cc3F)nc12 CHEMBL2335780 IC50 4.0 nM
CS(=O)(=O)Nc1cccc2c(O)cc(C(=O)Nc3ccccc3)nc12 CHEMBL2335742 IC50 4.0 nM
CN(c1cc(OCc2cc(F)c(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)nc(=O)n1C)C1CC1 CHEMBL3794025 IC50 4.0 nM
CCN(CC)c1cc(OCc2cc(F)c(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)nc(=O)n1C CHEMBL3793562 IC50 4.2 nM
COCCN(Cc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL312994 IC50 4.5 nM
Cn1c(N2CCC(F)(F)CC2)cc(OCc2cc(F)c(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)nc1=O CHEMBL3792972 IC50 4.6 nM
CCN(CC)CCN(Cc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)Cn1cc(C)c(=O)nc1SCc1ccc(F)cc1 CHEMBL10440 IC50 5.0 nM
Cn1cc(Cc2cn(CCCC(=O)N3CCN(c4ccc(C(F)(F)F)cc4)CC3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL294015 IC50 5.0 nM
Cn1cc(Cc2cn(CC(=O)N(CCCN3CCOCC3)Cc3ccc(-c4ccc(Cl)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL423867 IC50 5.0 nM
Cn1cc(Cc2cn(CCCC(=O)NCc3ccc(-c4ccccc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL150823 IC50 5.0 nM
CN(Cc1ccc(-c2ccc(S(C)(=O)=O)cc2)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL150078 IC50 5.0 nM
CN(Cc1ccc(-c2ccccc2)cc1)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL150336 IC50 5.0 nM
COc1ncc(Cc2cn(CCCC(=O)N(C)Cc3ccc(-c4ccc(Cl)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL153246 IC50 5.0 nM
CN(Cc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)CCCn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL273524 IC50 5.0 nM
CN(Cc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)Cn1cc(Cc2cnc(C(F)(F)F)nc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL348431 IC50 5.0 nM
N#Cc1cc(NS(=O)(=O)c2ccc(C(=O)O)cc2)ccc1Oc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL4076292 IC50 5.0 nM
CCN(CC)CCN(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)Cn1cc(CCNC(C)=O)c(=O)nc1SCc1ccc(F)cc1 CHEMBL10659 IC50 6.0 nM
Fc1cc(COc2ccn3c(-c4cncnc4)cnc3n2)cc(F)c1Oc1ccc(Cl)c(Cl)c1 CHEMBL3634557 IC50 6.3 nM
Fc1ccc(Oc2c(F)cc(COc3ccn4c(-c5cncnc5)cnc4n3)cc2F)cc1C(F)(F)F CHEMBL3634555 IC50 6.5 nM
CCCCCCCCNC(=O)Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL82900 IC50 7.0 nM
CCCCCCNC(=O)CCCn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL315341 IC50 7.0 nM
COc1ncc(Cc2cn(CCCC(=O)N3CCN(c4ccc(Cl)cc4)CC3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL57239 IC50 8.0 nM
COc1ncc(Cc2cn(CC(=O)N3CCN(c4ccc(Cl)c(Cl)c4)CC3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL56954 IC50 8.0 nM
CN(Cc1ccc(-c2ccc(F)cc2)cc1)C(=O)CCCn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL440360 IC50 8.0 nM
CN(Cc1ccc(-c2ccccc2)cc1)C(=O)Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL153701 IC50 8.0 nM
CCn1c(C)cc(OCc2cc(F)c(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)nc1=O CHEMBL3793795 IC50 8.0 nM
Cn1c(N2CCCCC2)cc(OCc2cc(F)c(Oc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)nc1=O CHEMBL3794546 IC50 8.3 nM
Cn1cc(Cc2cn(CCCC(=O)N3CCN(c4ccc(Cl)c(Cl)c4)CC3)c(SCc3ccc(F)cc3)nc2=O)cnc1=O CHEMBL301212 IC50 9.0 nM
O=C(O)Cn1cc(Cc2cn(CCCC(=O)N3CCN(c4ccc(Cl)c(Cl)c4)CC3)c(SCc3ccc(F)cc3)nc2=O)cnc1=O CHEMBL57213 IC50 9.0 nM
CC(=O)NCc1ccc(S(=O)(=O)Nc2ccc(Oc3ccc(Cl)c(C(F)(F)F)c3)c(C#N)c2)cc1 CHEMBL4066748 IC50 9.0 nM
COC(CO)Cc1csc(Nc2ccc(C)c(-c3ccccc3C)c2)n1 CHEMBL3819444 IC50 9.5 nM
O=C(Cn1cc(Cc2cnc(N3CCOCC3)nc2)c(=O)nc1SCc1ccc(F)cc1)N1CCN(c2ccc(Cl)cc2)CC1 CHEMBL57890 IC50 10.0 nM
FC(F)(F)c1cc(Oc2ccc(COc3ccn4c(-c5cncnc5)cnc4n3)cc2)ccc1Cl CHEMBL3634454 IC50 10.6 nM
Fc1cc(COc2ccn3c(-c4cncnc4)cnc3n2)cc(F)c1Oc1cccc(C(F)(F)F)c1 CHEMBL3634556 IC50 10.9 nM
O=C(CCCCCCCSc1nc(=O)c(Cc2cncnc2)cn1Cc1cccs1)c1ccc(Cl)cc1 CHEMBL85805 IC50 11.0 nM
FC(F)(F)c1cc(Oc2ccc(CCOc3ccn4c(-c5cncnc5)cnc4n3)cc2)ccc1Cl CHEMBL3634452 IC50 11.1 nM
Cn1cc(Cc2cn(CC(=O)N3CCN(c4ccc(Cl)c(Cl)c4)CC3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL58151 IC50 12.0 nM
CCCCCCc1ccc(CCn2cc(Cc3cncnc3)c(=O)nc2SCc2ccc(F)cc2)cc1 CHEMBL86017 IC50 12.0 nM
CC(=O)N(C)c1ccc(S(=O)(=O)Nc2ccc(Oc3ccc(Cl)c(C(F)(F)F)c3)c(C#N)c2)cc1 CHEMBL4060770 IC50 12.0 nM
CS(=O)(=O)Nc1cccc2c(O)cc(C(=O)Nc3ccccc3F)nc12 CHEMBL2335769 IC50 13.0 nM
N#Cc1cc(NS(=O)(=O)c2ccc(NC(=O)N3CCOCC3)cc2)ccc1Oc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL4088042 IC50 13.0 nM
CCN(CC)CCN(Cc1ccc(-c2ccc(C(F)(F)F)cc2OCC(F)(F)F)cc1)C(=O)/C=C1/OC(=O)N2CCC[C@@H]12 CHEMBL4638207 IC50 13.0 nM
COc1ncc(-c2cnc3nc(OCc4ccc(Oc5ccc(Cl)c(C(F)(F)F)c5)cc4)ccn23)cn1 CHEMBL3634545 IC50 13.4 nM
CS(=O)(=O)Nc1cccc2c(O)cc(C(=O)Nc3ccccc3C#N)nc12 CHEMBL2335770 IC50 14.0 nM
N#Cc1cc(NS(=O)(=O)c2ccc(N)cc2)ccc1Oc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL4088985 IC50 14.0 nM
COc1ncc(Cc2cn(CCCC(=O)N(C)Cc3ccc(-c4ccc(F)cc4)cc3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL153374 IC50 15.0 nM
CCCCCCCCN(C)C(=O)Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL87375 IC50 15.0 nM
O=C(CCCCCCCSc1nc(=O)c(Cc2cncnc2)cn1Cc1ccco1)c1ccc(Cl)cc1 CHEMBL87936 IC50 16.0 nM
Cc1ccccc1NC(=O)c1cc(O)c2cccc(O)c2n1 CHEMBL1945889 IC50 16.0 nM
Cc1ccccc1NC(=O)c1cc(O)c2cccc(NS(C)(=O)=O)c2n1 CHEMBL2335760 IC50 16.0 nM
FC(F)(F)c1cc(Oc2ccc(COc3ccn4c(-c5ccncc5)cnc4n3)cc2)ccc1Cl CHEMBL3634460 IC50 16.0 nM
Cn1cc(-c2cnc3nc(OCc4ccc(Oc5ccc(Cl)c(C(F)(F)F)c5)cc4)ccn23)cn1 CHEMBL3634546 IC50 16.9 nM
COc1ccc(-c2ccc(CN(C)C(=O)Cn3cc(Cc4cnn(C)c4)c(=O)nc3SCc3ccc(F)cc3)cc2)cc1 CHEMBL151063 IC50 17.0 nM
CC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(Oc3ccc(Cl)c(C(F)(F)F)c3)c(C#N)c2)cc1 CHEMBL4076690 IC50 17.0 nM
Cc1ncc(Cc2cn(CC(=O)N3CCN(c4ccc(Cl)cc4)CC3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL291535 IC50 18.0 nM
CCN(CC)CCN(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)Cn1cc(OC)c(=O)nc1SCc1ccc(F)cc1 CHEMBL10612 IC50 19.0 nM
Cn1cc(Cc2cncnc2)c(=O)nc1SCCCCCCCC(=O)c1ccc(Cl)cc1 CHEMBL419668 IC50 19.0 nM
CCCCCCCNC(=O)Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL313286 IC50 19.0 nM
CCCCCCCCCCCn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL86097 IC50 19.0 nM
FC(F)(F)c1cc(Oc2ccc(COc3ccn4c(-c5cccnc5)cnc4n3)cc2)ccc1Cl CHEMBL3634459 IC50 19.3 nM
COc1ncc(Cc2cn(CC(=O)N3CCN(c4ccc(Cl)cc4)CC3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL417780 IC50 20.0 nM
O=C(Nc1ccccc1)c1cc(O)c2cccc(O)c2n1 CHEMBL1945882 IC50 20.0 nM
O=C(Cn1cc(Cc2cnc(C3CC3)nc2)c(=O)nc1SCc1ccc(F)cc1)N1CCN(c2ccc(Cl)cc2)CC1 CHEMBL292367 IC50 21.0 nM
CS(=O)(=O)Nc1cccc2c(O)cc(C(=O)Nc3ccc(F)cc3O)nc12 CHEMBL2335786 IC50 22.0 nM
O=C(Nc1ccc(F)c(F)c1)c1cc(O)c2cccc(O)c2n1 CHEMBL1946063 IC50 23.0 nM
CS(=O)(=O)Nc1cccc2c(O)cc(C(=O)NC3CCCCCCCCC3)nc12 CHEMBL2335749 IC50 23.0 nM
CC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(Oc3ccc(C#N)c(C(F)(F)F)c3)c(C#N)c2)cc1 CHEMBL4070470 IC50 23.0 nM
CCCCCCCCN1CCN(C(=O)Cn2cc(Cc3cnn(C)c3)c(=O)nc2SCc2ccc(F)cc2)CC1 CHEMBL57979 IC50 24.0 nM
O=C(Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1)NCc1cccc(-c2ccccc2)c1 CHEMBL345781 IC50 24.0 nM
O=c1nc(SCc2ccc(F)cc2)n(CCCCCCCCCc2ccccc2)cc1Cc1cncnc1 CHEMBL86033 IC50 25.0 nM
O=C(Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1)N1CCN(c2ccc(Cl)cc2)CC1 CHEMBL418113 IC50 26.0 nM
O=C(Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1)N1CCN(c2ccc(C(F)(F)F)cc2)CC1 CHEMBL294196 IC50 26.0 nM
CS(=O)(=O)Nc1cccc2c(O)cc(C(=O)Nc3cccc(F)c3F)nc12 CHEMBL2335779 IC50 26.0 nM
CS(=O)(=O)Nc1cccc2c(O)cc(C(=O)Nc3ccc(F)cc3)nc12 CHEMBL2335768 IC50 26.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(C(c2cccnc2)c2cccnc2)CC1 CHEMBL3910417 IC50 26.0 nM
Cc1ccc(F)cc1NC(=O)c1cc(O)c2cccc(NS(C)(=O)=O)c2n1 CHEMBL2335782 IC50 28.0 nM
CN(C)c1ncc(Cc2cn(CC(=O)N3CCN(c4ccc(Cl)cc4)CC3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL21022 IC50 29.0 nM
O=C(Nc1ccc(F)cc1F)c1cc(O)c2cccc(O)c2n1 CHEMBL1946061 IC50 30.0 nM
O=C(Nc1ccc(F)cc1)c1cc(O)c2cccc(O)c2n1 CHEMBL1945886 IC50 31.0 nM
CS(=O)(=O)Nc1cccc2c(O)cc(C(=O)Nc3cccc(F)c3)nc12 CHEMBL2335767 IC50 31.0 nM
CCCC[C@H](C)NC(=O)c1cc(O)c2cccc(NS(C)(=O)=O)c2n1 CHEMBL2335755 IC50 32.0 nM
CS(=O)(=O)Nc1cccc2c(O)cc(C(=O)NC3CCCCCCCC3)nc12 CHEMBL2335748 IC50 32.0 nM
CC1([C@@H]2CC(=O)N(CCOc3ccc(F)c(C#N)c3)C2)CCS(=O)(=O)CC1 CHEMBL3922315 IC50 32.0 nM
CC(C)(C)c1ncc(Cc2cn(CC(=O)N3CCN(c4ccc(Cl)cc4)CC3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL57353 IC50 34.0 nM
O=C(CCCCCCCSc1nc(=O)c(Cc2cncnc2)cn1CCc1ccccc1)c1ccc(Cl)cc1 CHEMBL86244 IC50 34.0 nM
O=C(NC1CCCCC1)c1cc(O)c2cccc(O)c2n1 CHEMBL1946064 IC50 34.0 nM
O=C(CCCCCCCSc1nc(=O)c(Cc2cncnc2)cn1Cc1ccccc1)c1ccc(Cl)cc1 CHEMBL85598 IC50 36.0 nM
CCN(CC)CCN(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)Cn1cc(CCN)c(=O)nc1SCc1ccc(F)cc1 CHEMBL10619 IC50 38.0 nM
CS(=O)(=O)Nc1cccc2c(O)cc(C(=O)NC3CCCCCCC3)nc12 CHEMBL2335747 IC50 38.0 nM
O=C(Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1)N1CCN(c2ccccc2Cl)CC1 CHEMBL298617 IC50 39.0 nM
CCn1cc(Cc2cncnc2)c(=O)nc1SCCCCCCCC(=O)c1ccc(Cl)cc1 CHEMBL87591 IC50 39.0 nM
CS(=O)(=O)Nc1cccc2c(O)cc(C(=O)Nc3cc(F)ccc3F)nc12 CHEMBL2335778 IC50 39.0 nM
CS(=O)(=O)Nc1cccc2c(O)cc(C(=O)Nc3ccccc3N)nc12 CHEMBL2335771 IC50 39.0 nM
Cn1ccc(Cc2cnc(SCCCCCCCC(=O)c3ccc(Cl)cc3)nc2O)cc1=O CHEMBL128727 Ki 41.0 nM
N#Cc1cc(NS(=O)(=O)c2ccc(N3CCOCC3)cc2)ccc1Oc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL4074539 IC50 42.0 nM
Cn1cc(Cc2cn(CC(=O)N3CCN(c4ccc(Cl)cc4)CC3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL440674 IC50 44.0 nM
CCc1ccccc1NC(=O)c1cc(O)c2cccc(NS(C)(=O)=O)c2n1 CHEMBL2335763 IC50 44.0 nM
CC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(Oc3ccc(Cl)c(Cl)c3)c(C#N)c2)cc1 CHEMBL4097263 IC50 45.0 nM
CC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(Oc3ccc(F)c(C(F)(F)F)c3)c(C#N)c2)cc1 CHEMBL4099132 IC50 45.0 nM
CS(=O)(=O)Nc1cccc2c(O)cc(C(=O)Nc3ccccc3O)nc12 CHEMBL2335772 IC50 49.0 nM
CCN(CC)CCN(Cc1ccc(-c2ccc(Cl)cc2)cc1)C(=O)Cn1ccc(=O)nc1SCc1ccc(F)cc1 CHEMBL10864 IC50 50.0 nM
CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O CHEMBL175247 IC50 50.0 nM
Cn1cc(Cc2cn(CC(=O)N3CCN(c4ccc(Br)cc4)CC3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL292231 IC50 51.0 nM
CS(=O)(=O)Nc1cccc2c(O)cc(C(=O)Nc3ccccc3Cl)nc12 CHEMBL2335773 IC50 52.0 nM
CC(C)(C)OC(=O)Cn1c(SCc2ccc(F)cc2)nc(=O)c2c1CCC2 CHEMBL4208988 IC50 52.4 nM
Cc1cccc(NC(=O)c2cc(O)c3cccc(O)c3n2)c1 CHEMBL1945888 IC50 53.0 nM
O=C(CCCCCCCSc1ncc(Cc2cncnc2)c(O)n1)c1ccc(Cl)cc1 CHEMBL85927 IC50 54.0 nM
O=C(Nc1cccc(F)c1F)c1cc(O)c2cccc(O)c2n1 CHEMBL1946062 IC50 55.0 nM
Cc1cccc(F)c1NC(=O)c1cc(O)c2cccc(NS(C)(=O)=O)c2n1 CHEMBL2335781 IC50 55.0 nM
CS(=O)(=O)Nc1cccc2c(O)cc(C(=O)NC3CCCCCC3)nc12 CHEMBL2335746 IC50 55.0 nM
O=C(NC12CC3CC(CC(C3)C1)C2)c1cc(O)c2cccc(O)c2n1 CHEMBL1946067 IC50 56.0 nM
N#Cc1cc(NS(=O)(=O)c2ccc(N3CCNCC3)cc2)ccc1Oc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL4096131 IC50 57.0 nM
O=C(Nc1ccc(Cl)cc1)c1cc(O)c2cccc(O)c2n1 CHEMBL1945885 IC50 61.0 nM
O=C(CCCCCCCOc1ncc(Cc2cccnc2)c(O)n1)c1ccc(Cl)cc1 CHEMBL128225 IC50 64.0 nM
N#Cc1cc(NS(=O)(=O)c2ccccc2)ccc1Oc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL4091394 IC50 65.0 nM
O=C(Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1)N1CCN(c2cccc(Cl)c2)CC1 CHEMBL59377 IC50 66.0 nM
O=C(Cn1cc(Cc2cnc(C(F)(F)F)nc2)c(=O)nc1SCc1ccc(F)cc1)N1CCN(c2ccc(Cl)cc2)CC1 CHEMBL56237 IC50 69.0 nM
Cn1cc(Cc2cn(CC(=O)N3CCN(c4ccc(Cl)cc4)CC3)c(SCc3ccc(F)cc3)nc2=O)cnc1=O CHEMBL57049 IC50 70.0 nM
CCCCCCCNC(=O)NCCn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL85739 IC50 70.0 nM
Cc1cccc(NC(=O)c2cc(O)c3cccc(NS(C)(=O)=O)c3n2)c1 CHEMBL2335761 IC50 70.0 nM
CN1CCC(C)([C@@H]2CC(=O)N(CCOc3ccc(F)c(C#N)c3)C2)CC1 CHEMBL3985490 IC50 72.0 nM
CN1CCC(C)(C2CC(=O)N(CCOc3ccc(F)c(C#N)c3)C2)CC1 CHEMBL3897162 IC50 75.0 nM
CS(=O)(=O)Nc1cccc2c(O)cc(C(=O)Nc3cccc(F)c3O)nc12 CHEMBL2335785 IC50 80.0 nM
O=C(Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1)N1CCN(Cc2ccccc2)CC1 CHEMBL292458 IC50 85.0 nM
CC1([C@@H]2CC(=O)N(CCOc3ccc(F)c(F)c3)C2)CCS(=O)(=O)CC1 CHEMBL3957888 IC50 86.0 nM
Cc1ccc(NC(=O)c2cc(O)c3cccc(NS(C)(=O)=O)c3n2)cc1 CHEMBL2335762 IC50 87.0 nM
O=C(O)Cn1cc(Cc2cn(CC(=O)N3CCN(c4ccc(Cl)cc4)CC3)c(SCc3ccc(F)cc3)nc2=O)cnc1=O CHEMBL56121 IC50 89.0 nM
O=C(CCCCCCCSc1nc(=O)c(Cc2cncnc2)cn1CCCc1ccccc1)c1ccc(Cl)cc1 CHEMBL87892 IC50 90.0 nM
O=C(NCc1ccc(F)cc1)c1cc(O)c2cccc(O)c2n1 CHEMBL1946069 IC50 91.0 nM
O=C(NC1CCCCCC1)c1cc(O)c2cccc(O)c2n1 CHEMBL1946066 IC50 92.0 nM
Cn1ncc2cc(C(c3ccc4c(cnn4C)c3)N3CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC3)ccc21 CHEMBL4469632 IC50 93.0 nM
O=C(Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1)N1CCN(c2ccc(F)cc2)CC1 CHEMBL56892 IC50 97.0 nM
CS(=O)(=O)Nc1cccc2c(O)cc(C(=O)Nc3c(F)cccc3F)nc12 CHEMBL2335777 IC50 100.0 nM
CCCCC[C@H](C)NC(=O)c1cc(O)c2cccc(NS(C)(=O)=O)c2n1 CHEMBL2335757 IC50 100.0 nM
CC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(Oc3ccc(Cl)c(C)c3)c(C#N)c2)cc1 CHEMBL4104461 IC50 100.0 nM
O=C(CCCCCCCSc1ncc(Cc2cccnc2)c(O)n1)c1ccc(Cl)cc1 CHEMBL129754 IC50 110.0 nM
O=c1nc(SCc2ccc(F)c(F)c2)n(CCc2ccccc2)cc1Cc1cncnc1 CHEMBL86256 IC50 110.0 nM
COCCn1cc(Cc2cncnc2)c(=O)nc1SCCCCCCCC(=O)c1ccc(Cl)cc1 CHEMBL85600 IC50 110.0 nM
CC1(C2CC(=O)N(CCOc3ccc(F)c(C#N)c3)C2)CCS(=O)(=O)CC1 CHEMBL3977401 IC50 110.0 nM
O=C(Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1)N1CCN(c2ccccc2)CC1 CHEMBL58530 IC50 120.0 nM
N#C/C(=N\OC(=O)N1CCOCC1)c1ccccc1 CHEMBL373696 IC50 120.0 nM
CS(=O)(=O)Nc1cccc2c(O)cc(C(=O)Nc3ccccc3C(F)(F)F)nc12 CHEMBL2335774 IC50 120.0 nM
CC(=O)c1ccc(N2CCN(C(=O)Cn3cc(Cc4cncnc4)c(=O)nc3SCc3ccc(F)cc3)CC2)cc1 CHEMBL57720 IC50 130.0 nM
Cc1ccc(NC(=O)c2cc(O)c3cccc(O)c3n2)cc1 CHEMBL1945887 IC50 130.0 nM
O=C(Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1)N1CCN(Cc2ccc(Cl)cc2)CC1 CHEMBL299694 IC50 140.0 nM
CCCCCCCC(=O)NCCn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL85932 IC50 140.0 nM
O=c1nc(SCc2ccccc2)n(Cc2ccco2)cc1Cc1cncnc1 CHEMBL85359 IC50 150.0 nM
CCCCCCC[C@H](C)NC(=O)c1cc(O)c2cccc(NS(C)(=O)=O)c2n1 CHEMBL2335759 IC50 150.0 nM
CCCCCC[C@H](C)NC(=O)c1cc(O)c2cccc(NS(C)(=O)=O)c2n1 CHEMBL2335758 IC50 150.0 nM
CC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(Oc3ccc(Cl)c(C#N)c3)c(C#N)c2)cc1 CHEMBL4075421 IC50 152.0 nM
CC1(C2CC(=O)N(CCOc3ccc(F)c(C#N)c3)C2)CCOCC1 CHEMBL3960825 IC50 160.0 nM
CC1(C2CC(=O)N(CCOc3ccc(F)c(F)c3)C2)CCS(=O)(=O)CC1 CHEMBL3939387 IC50 160.0 nM
O=C(NC1CCCC1)c1cc(O)c2cccc(O)c2n1 CHEMBL1946065 IC50 170.0 nM
COc1ccc(N2CCN(C(=O)Cn3cc(Cc4cncnc4)c(=O)nc3SCc3ccc(F)cc3)CC2)cc1 CHEMBL60630 IC50 176.0 nM
Cc1ccc(C(=O)N2CC=CC2)cc1-c1ccccc1Cl CHEMBL3819632 IC50 180.0 nM
O=C(Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1)NCc1ccccc1-c1ccccc1 CHEMBL153415 IC50 194.0 nM
Oc1nc(SCCCCCCCCc2ccc(Cl)cc2)ncc1Cc1cccnc1 CHEMBL129626 IC50 200.0 nM
O=c1nc(SCc2ccc(F)cc2)n(CCc2ccccc2)cc1Cc1cncnc1 CHEMBL85648 IC50 200.0 nM
O=c1nc(SCc2ccccc2)n(Cc2cccs2)cc1Cc1cncnc1 CHEMBL313178 IC50 210.0 nM
O=c1nc(SCc2ccccc2)n(CCc2ccccc2)cc1Cc1cncnc1 CHEMBL86461 IC50 210.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(C(c2cocn2)c2cocn2)CC1 CHEMBL3986768 IC50 210.0 nM
CC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(Oc3ccc(Cl)c(F)c3)c(C#N)c2)cc1 CHEMBL4086960 IC50 222.0 nM
Oc1nc(SCCCCCCCOc2ccc(Cl)cc2)ncc1Cc1cccnc1 CHEMBL129779 IC50 230.0 nM
CS(=O)(=O)Nc1cccc2c(O)cc(C(=O)NC3CCCCC3)nc12 CHEMBL2335745 IC50 230.0 nM
Cc1ccccc1-c1cc(C(=O)N2CC=CC2)ccc1C CHEMBL3818759 IC50 230.0 nM
Cc1ccccc1-c1cc(Nc2nc(CCCO)cs2)ccc1C CHEMBL3819367 IC50 230.0 nM
Cc1ccc(S(=O)(=O)Nc2ccc(Oc3ccc(Cl)c(C(F)(F)F)c3)c(C#N)c2)cc1 CHEMBL4096681 IC50 232.0 nM
O=c1nc(SCc2ccc(F)c(F)c2)n(Cc2ccco2)cc1Cc1cncnc1 CHEMBL313811 IC50 235.0 nM
N#Cc1cc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)ccc1Oc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL4069457 IC50 236.0 nM
CCCc1ccccc1NC(=O)c1cc(O)c2cccc(NS(C)(=O)=O)c2n1 CHEMBL2335764 IC50 240.0 nM
Cn1ccc(Cc2cnc(SCCCCCCCCc3ccccc3)nc2O)cc1=O CHEMBL340482 IC50 250.0 nM
Oc1nc(SCCCCCCCSc2ccc(Cl)cc2)ncc1Cc1cccnc1 CHEMBL340004 IC50 250.0 nM
O=c1nc(SCc2cccc(F)c2)n(Cc2ccco2)cc1Cc1cncnc1 CHEMBL85494 IC50 250.0 nM
O=c1nc(SCc2ccc(F)cc2)n(CCc2cccs2)cc1Cc1cncnc1 CHEMBL313777 IC50 250.0 nM
C#Cc1ccccc1NC(=O)c1cc(O)c2cccc(NS(C)(=O)=O)c2n1 CHEMBL2335775 IC50 250.0 nM
CC(=O)N1CCC(C)(C2CC(=O)N(CCOc3ccc(F)c(C#N)c3)C2)CC1 CHEMBL3959796 IC50 250.0 nM
O=C(Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1)N1CCN(S(=O)(=O)c2ccccc2)CC1 CHEMBL292455 IC50 260.0 nM
CCCCNC(=O)CCCCCn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL313621 IC50 260.0 nM
COc1ccc(NC(=O)c2cc(O)c3cccc(O)c3n2)cc1 CHEMBL1945884 IC50 270.0 nM
Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL86317 IC50 285.0 nM
O=c1nc(SCc2ccc(F)cc2)n(Cc2ccco2)cc1Cc1cncnc1 CHEMBL316253 IC50 300.0 nM
O=c1nc(SCc2ccccc2)n(CCCc2ccccc2)cc1Cc1cncnc1 CHEMBL86019 IC50 300.0 nM
CC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(Oc3ccc(Cl)cc3)c(C#N)c2)cc1 CHEMBL4082492 IC50 322.0 nM
Oc1nc(SCCCCCCCCc2ccccc2)ncc1Cc1cccnc1 CHEMBL339639 IC50 330.0 nM
C#Cc1ccc(CN2CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC2)c(N2CCCC2)c1 CHEMBL4529300 IC50 330.0 nM
O=C(Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1)N1CCN(c2ccccn2)CC1 CHEMBL57488 IC50 350.0 nM
O=c1nc(SCc2ccccc2)n(CCc2cccs2)cc1Cc1cncnc1 CHEMBL84776 IC50 350.0 nM
CC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(Oc3ccc4ccccc4c3)c(C#N)c2)cc1 CHEMBL4075815 IC50 355.0 nM
CCCCCNC(=O)c1cc(O)c2cccc(O)c2n1 CHEMBL1946068 IC50 360.0 nM
C[C@H](NC(=O)c1cc(O)c2cccc(NS(C)(=O)=O)c2n1)c1ccccc1 CHEMBL2335751 IC50 370.0 nM
O=C(Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1)N1CCN(c2cncnc2)CC1 CHEMBL294446 IC50 410.0 nM
Oc1nc(SCCCCCCCCCc2ccccc2)ncc1Cc1cccnc1 CHEMBL130018 IC50 430.0 nM
CN1CC2CN(c3cc(C(F)(F)F)ccc3CN3CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC3)CC2C1 CHEMBL4546592 IC50 430.0 nM
CS(=O)(=O)c1ccc(CN2CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC2)c(N2CCCC2)c1 CHEMBL4436074 IC50 430.0 nM
O=c1nc(SCc2ccccc2F)n(Cc2ccco2)cc1Cc1cncnc1 CHEMBL86146 IC50 450.0 nM
O=c1nc(SCc2ccccc2)n(Cc2ccccc2)cc1Cc1cncnc1 CHEMBL313717 IC50 450.0 nM
COc1ccccc1NC(=O)c1cc(O)c2cccc(NS(C)(=O)=O)c2n1 CHEMBL2335776 IC50 450.0 nM
O=C(Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccc(F)cc1)N1CCNCC1 CHEMBL292432 IC50 460.0 nM
Cn1cc(Cc2cn(CC(=O)N3CCN(Cc4ccccc4)C(=O)C3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL301878 IC50 530.0 nM
CCCCCCCCCCCCN(C)C(=O)Cn1cc(Cc2cnc(=O)n(CC(=O)O)c2)c(=O)nc1SCc1ccc(F)cc1 CHEMBL351434 IC50 533.0 nM
Cn1nc(-c2ccccc2)cc1CN1CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC1 CHEMBL3941394 IC50 580.0 nM
CC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(Oc3ccc(C#N)cc3)c(C#N)c2)cc1 CHEMBL4064714 IC50 613.0 nM
CC1(C2CC(=O)N(CCOc3ccc(F)c(C#N)c3)C2)CCNCC1 CHEMBL3933361 IC50 620.0 nM
Oc1nc(SCCCCCCCCc2ccccc2)ncc1Cc1ccncc1 CHEMBL128811 IC50 630.0 nM
O=C(CCCCCCCSc1ncc(Cc2cnccn2)c(O)n1)c1ccc(Cl)cc1 CHEMBL340387 IC50 640.0 nM
O=C(CCCCCCCCSc1ncc(Cc2cccnc2)c(O)n1)c1ccc(Cl)cc1 CHEMBL128323 IC50 650.0 nM
Cn1cc(Cc2cncnc2)c(=O)nc1SCc1ccccc1 CHEMBL313514 IC50 660.0 nM
Cn1cc(Cc2cn(CC(=O)N3CCN(C4CCCCC4)CC3)c(SCc3ccc(F)cc3)nc2=O)cn1 CHEMBL57591 IC50 720.0 nM
CC(=O)N1CCC(c2nn(C)cc2CN2CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC2)CC1 CHEMBL4458086 IC50 750.0 nM
CC1(C2CC(=O)N(CCOc3ccc(F)cc3)C2)CCS(=O)(=O)CC1 CHEMBL3923643 IC50 760.0 nM
Cc1ccc(Cc2cnc(SCCCCCCCCc3ccccc3)nc2O)cn1 CHEMBL129630 IC50 780.0 nM
CCCCn1ccc(Cc2cnc(SCCCCCCCCc3ccccc3)nc2O)cc1=O CHEMBL128840 IC50 780.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(Cl)cc2N2CCCC2)CC1 CHEMBL3891077 IC50 810.0 nM
CC[C@H](CC#N)NC(=O)c1cc(O)c2cccc(NS(C)(=O)=O)c2n1 CHEMBL2335753 IC50 820.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(Cl)cc2N2CC[C@H]3CCCN3C2)CC1 CHEMBL4435014 IC50 844.0 nM
Oc1nc(SCCCCCCCCc2cccc(Cl)c2)ncc1Cc1cccnc1 CHEMBL129024 IC50 850.0 nM
Oc1nc(SCc2ccc(F)cc2)ncc1Cc1cncnc1 CHEMBL128352 IC50 850.0 nM
N#Cc1cc(OCCN2CC(c3ccccc3)CC2=O)ccc1F CHEMBL3913442 IC50 860.0 nM
CC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(Oc3ccc(Cl)c(Cc4ccccc4)c3)c(C#N)c2)cc1 CHEMBL4066303 IC50 902.0 nM
COc1cc(Oc2ccc(NS(=O)(=O)c3ccc(NC(C)=O)cc3)cc2C#N)ccc1Cl CHEMBL4087657 IC50 924.0 nM
Cn1cc(CN2CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC2)c(-c2ccccc2Cl)n1 CHEMBL3894067 IC50 930.0 nM
O=c1nc(SCc2cccc(Cl)c2)n(Cc2ccco2)cc1Cc1cncnc1 CHEMBL88065 IC50 960.0 nM
CCCC[C@@H](C)NC(=O)c1cc(O)c2cccc(NS(C)(=O)=O)c2n1 CHEMBL2335756 IC50 980.0 nM
CC(C)(C)C1CC(=O)N(CCOc2ccc(F)c(C#N)c2)C1 CHEMBL3971940 IC50 980.0 nM
Cc1ccc(Cc2cnc(SCCCCCCCCCc3ccccc3)nc2O)cn1 CHEMBL129072 IC50 990.0 nM
COc1cc(Cc2cnc(SCCCCCCCCc3ccccc3)nc2O)ccn1 CHEMBL129169 IC50 1000.0 nM
Oc1cc(Cc2cnc(SCCCCCCCCc3ccccc3)nc2O)ccn1 CHEMBL339965 IC50 1000.0 nM
Cc1ccc(Cc2cnc(SCCCCCCCc3ccccc3)nc2O)cn1 CHEMBL131224 IC50 1000.0 nM
C[C@]1(c2ccccc2)CC(=O)N(CCOc2ccc(F)c(C#N)c2)C1 CHEMBL3924430 IC50 1000.0 nM
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(C(F)(F)F)cc2N2CC3COCC3C2)CC1 CHEMBL4468636 IC50 1000.0 nM