O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1cc2cc(F)ccc2[nH]1 CHEMBL398567 IC50 1.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NC[C@H]2c1ccc(F)cc1)NC(=O)c1cc2ccccc2[nH]1 CHEMBL4453586 IC50 1.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)C1C[C@@H]1c1ccccc1 CHEMBL2304616 IC50 2.0 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3ccc(F)cc32)CC1)NC(=O)c1ccc2ccccc2c1 CHEMBL493521 IC50 2.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3cc(Br)ccc32)CC1)c1ccc(Cl)cc1 CHEMBL492561 IC50 3.0 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)NC(=O)c1ccc(F)c(F)c1 CHEMBL492558 IC50 3.0 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(Br)ccc32)CC1)NC(=O)c1ccc(F)c(F)c1 CHEMBL492559 IC50 3.5 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(Br)ccc32)CC1)NC(=O)[C@@H]1C[C@H]1c1ccccc1 CHEMBL524182 IC50 3.7 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(Br)ccc32)CC1)NC(=O)[C@@H]1C[C@@H]1c1ccccc1 CHEMBL3947795 IC50 3.7 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3cc(F)ccc32)CC1)c1ccc2ccccc2c1 CHEMBL493010 IC50 4.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3cc(Br)ccc32)CC1)c1ccc(F)cc1 CHEMBL521990 IC50 4.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccc(F)cc32)CC1)c1ccc(F)c(F)c1 CHEMBL492972 IC50 4.0 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(Br)ccc32)CC1)NC(=O)c1ccc(Cl)cc1 CHEMBL523011 IC50 4.0 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(Br)ccc32)CC1)NC(=O)c1ccc2ccccc2c1 CHEMBL492704 IC50 5.5 nM
Cc1cccc(N2CNC(=O)C23CCN(C[C@H](C)NC(=O)c2ccc(Br)cc2)CC3)c1 CHEMBL2325485 IC50 6.0 nM
CC(CNC(=O)c1cc2ccccc2[nH]1)N1CCC2(CC1)C(=O)NCN2c1ccccc1 CHEMBL3357311 IC50 6.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)NC(=O)c1ccc(Br)cc1 CHEMBL4446255 IC50 6.0 nM
O=C(NCCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)cc1 CHEMBL1213097 IC50 6.3 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)NC(=O)c1ccc(Cl)cc1 CHEMBL494145 IC50 6.4 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccc(F)cc32)CC1)c1ccc(Cl)cc1 CHEMBL492971 IC50 7.0 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(F)ccc32)CC1)NC(=O)c1ccc(Cl)cc1 CHEMBL522488 IC50 7.4 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1cnc2ccccc2c1 CHEMBL246032 IC50 8.0 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)NC(=O)[C@@H]1C[C@H]1c1ccccc1 CHEMBL521677 IC50 8.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1cc(Br)c(Br)o1 CHEMBL1213066 IC50 8.9 nM
Cc1ccc(C(=O)NCCN2CCC(n3c(=O)[nH]c4cc(Cl)ccc43)CC2)cc1 CHEMBL494183 IC50 10.0 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)NC(=O)c1ccc(F)cc1 CHEMBL492589 IC50 10.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)NC(=O)c1ccc2ccccc2c1 CHEMBL1254495 IC50 10.0 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(F)ccc32)CC1)NC(=O)c1ccc(F)cc1 CHEMBL492588 IC50 11.0 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)NC(=O)c1ccc2ccccc2c1 CHEMBL492572 IC50 11.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3cc(F)ccc32)CC1)c1ccc(F)cc1 CHEMBL492369 IC50 12.0 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3ccc(F)cc32)CC1)NC(=O)[C@@H]1C[C@H]1c1ccccc1 CHEMBL493736 IC50 12.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1cc2ccccc2s1 CHEMBL398568 IC50 14.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NC[C@@H]2c1ccc(F)cc1)NC(=O)c1cc2ccccc2[nH]1 CHEMBL4448918 IC50 16.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NC[C@H]2c1ccc(F)cc1)NC(=O)C#Cc1ccccc1 CHEMBL4514153 IC50 16.0 nM
O=C(NCCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(F)c(F)c1 CHEMBL1213067 IC50 17.0 nM
CC(CNC(=O)c1ccc(F)c(F)c1)N1CCC2(CC1)C(=O)NCN2c1ccccc1 CHEMBL3357312 IC50 17.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3cc(F)ccc32)CC1)c1ccc(Cl)cc1 CHEMBL523162 IC50 18.0 nM
CC(CNC(=O)c1cc2cc(F)ccc2[nH]1)N1CCC2(CC1)C(=O)NCN2c1ccccc1 CHEMBL3357310 IC50 18.0 nM
O=C(NCCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 CHEMBL1213069 IC50 19.0 nM
O=C(NCCN1CCC(n2c(O)nc3ccccc32)CC1)c1cccc2c1-c1ccccc1C2=O CHEMBL1213068 IC50 20.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)NC(=O)c1ccc(F)cc1 CHEMBL2325482 IC50 20.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1ccc2ccccc2c1 CHEMBL492797 IC50 21.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1ccc(F)cc1 CHEMBL245621 IC50 21.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)C(F)C1)c1ccc(F)c(F)c1 CHEMBL3357315 IC50 21.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NC[C@H]2c1ccc(F)cc1)c1cc2ccccc2[nH]1 CHEMBL4475943 IC50 21.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1ccco1 CHEMBL1213141 IC50 22.0 nM
C[C@@H](CN1CCC2(CC1)OC(=O)NC[C@H]2c1cccc(F)c1)NC(=O)c1ccc(F)cc1 CHEMBL5085284 IC50 22.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NCN2c1ccccc1)NC(=O)c1ccc2ccccc2c1 CHEMBL471056 IC50 25.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NC[C@H]2c1ccc(F)cc1)NC(=O)c1cnc2ccccc2c1 CHEMBL4570440 IC50 25.0 nM
Cc1ccc(C(=O)NCCN2CCC(n3c(O)nc4ccccc43)CC2)cc1 CHEMBL1213140 IC50 32.0 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3ccccc32)CC1)NC(=O)c1ccc(F)cc1 CHEMBL5078848 IC50 33.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)[C@@H]1C[C@H]1c1ccccc1 CHEMBL524008 IC50 35.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1ccc[nH]1 CHEMBL1213143 IC50 37.0 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3c(F)cccc32)CC1)NC(=O)c1ccc(F)c(F)c1 CHEMBL492379 IC50 38.0 nM
O=C(C#Cc1ccccc1)NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1 CHEMBL494007 IC50 40.0 nM
C[C@@H]1CN(C(=O)[C@H](C)N2CCC(n3c(=O)[nH]c4ccccc43)CC2)C[C@H](C)N1 CHEMBL5092677 IC50 40.0 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3c(F)cccc32)CC1)NC(=O)c1ccc(Cl)cc1 CHEMBL495349 IC50 43.0 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3ccccc32)CC1)n1ccccc1=O CHEMBL5078394 IC50 43.0 nM
C[C@@H]1CN(C(=O)[C@H](C)N2CCC(n3c(=O)[nH]c4ccccc43)CC2)C[C@@H](C)N1 CHEMBL5085809 IC50 44.0 nM
O=C(c1ccc(F)cc1)N(CCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)C(=O)c1ccc(F)cc1 CHEMBL1213100 IC50 48.0 nM
COc1cc(C(=O)NCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)cc(OC)c1OC CHEMBL1213144 IC50 51.0 nM
CC(CNC(=O)c1ccc2ccccc2c1)N1CCC2(CC1)C(=O)NCN2c1ccccc1 CHEMBL3357307 IC50 64.0 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3c(F)cccc32)CC1)NC(=O)c1ccc2ccccc2c1 CHEMBL492380 IC50 66.0 nM
C[C@@H](CN1CCC2(CC1)OC(=O)Nc1ccccc12)NC(=O)c1ccc(F)cc1 CHEMBL5092708 IC50 66.0 nM
CC[C@H]1CN(C(=O)[C@H](C)N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CCN1 CHEMBL5088048 IC50 68.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1ccc2ncccc2c1 CHEMBL494008 IC50 70.0 nM
C[C@@H](CN1CCC2(CC1)OC(=O)Nc1cc(F)ccc12)NC(=O)c1ccc(F)cc1 CHEMBL5083605 IC50 71.0 nM
O=C(NCCN1CC2CC(n3c(=O)[nH]c4ccccc43)CC2C1)c1cc2ccccc2[nH]1 CHEMBL3357320 IC50 72.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCC2c1ccc(F)cc1)c1ccc2ccccc2c1 CHEMBL3925473 IC50 73.0 nM
C[C@H](CN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)NC(=O)c1ccc(Br)cc1 CHEMBL2325486 IC50 75.0 nM
C[C@H]1CN(C(=O)[C@H](C)N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CCN1 CHEMBL5086717 IC50 76.0 nM
C=Cc1ccc(C(=O)NCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)cc1 CHEMBL1213142 IC50 79.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1cc(Cl)cc(Cl)c1 CHEMBL1213190 IC50 85.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)NC(=O)c1ccc(F)c(F)c1 CHEMBL2325487 IC50 86.0 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3c(F)cccc32)CC1)NC(=O)[C@@H]1C[C@H]1c1ccccc1 CHEMBL494587 IC50 100.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NC[C@@H]2c1ccc(F)cc1)NC(=O)c1cnc2ccccc2c1 CHEMBL3902347 IC50 100.0 nM
C[C@@H]1CN(C(=O)[C@H](C)N2CCC(n3c(=O)[nH]c4ccccc43)CC2)Cc2ccccc21 CHEMBL5074314 IC50 100.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)C1=CCc2ccccc2C1 CHEMBL494842 IC50 110.0 nM
C[C@@H](CN1CCC2(CC1)OC(=O)Nc1ccncc12)NC(=O)c1ccc(F)cc1 CHEMBL5092706 IC50 110.0 nM
CC1CC(n2c(=O)[nH]c3ccccc32)CCN1CCNC(=O)[C@@H]1C[C@H]1c1ccccc1 CHEMBL3357314 IC50 115.0 nM
O=C(NCCN1CC2CC(n3c(=O)[nH]c4ccccc43)CC2C1)[C@@H]1C[C@H]1c1ccccc1 CHEMBL3357322 IC50 115.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1ccc2cc(F)ccc2c1 CHEMBL495018 IC50 120.0 nM
CC(CNC(=O)c1ccc(Br)cc1)N1CCC2(CC1)C(=O)NCN2c1ccccc1 CHEMBL3357309 IC50 120.0 nM
O=c1ccccn1CCN1CCC(n2c(=O)[nH]c3ccccc32)CC1 CHEMBL5075520 IC50 120.0 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3c(F)cccc32)CC1)NC(=O)c1ccc(F)cc1 CHEMBL523496 IC50 130.0 nM
CC(=O)N(C)CCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1 CHEMBL5076666 IC50 130.0 nM
C[C@@H]1CNCCN1C(=O)[C@H](C)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 CHEMBL5080858 IC50 140.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1cc2ccccc2s1 CHEMBL471257 IC50 150.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NCN2c1ccccc1)NC(=O)c1ccc(F)c(F)c1 CHEMBL511648 IC50 150.0 nM
C[C@@H](C(=O)N1CCC(F)(F)C1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 CHEMBL5086297 IC50 170.0 nM
C[C@@H](CN1CCC2(CC1)OC(=O)Nc1cccnc12)NC(=O)c1ccc(F)cc1 CHEMBL5080277 IC50 200.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)c1cc2cc(F)ccc2[nH]1 CHEMBL1254736 IC50 210.0 nM
O=C(NCCN1CC2CC(n3c(=O)[nH]c4ccccc43)CC2C1)c1cc2cc(F)ccc2[nH]1 CHEMBL3357319 IC50 230.0 nM
O=C(NCCN1CC2CC(n3c(=O)[nH]c4ccccc43)CC2C1)c1ccc2ccccc2c1 CHEMBL3357316 IC50 244.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1cccc(Cl)c1)c1cc2cc(F)ccc2[nH]1 CHEMBL1254908 IC50 250.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NC[C@H]2c1ccc(F)cc1)NC(=O)c1ccc(F)cc1 CHEMBL4581260 IC50 250.0 nM
C[C@@H](CN1CCC2(CC1)NC(=O)Nc1ccccc12)NC(=O)c1ccc(F)cc1 CHEMBL5080618 IC50 280.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccc(F)cc1)c1cc2cc(F)ccc2[nH]1 CHEMBL1253900 IC50 290.0 nM
CC(CNC(=O)c1ccc(F)cc1)N1CCC2(CC1)C(=O)NCN2c1ccccc1 CHEMBL3357308 IC50 290.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)n1c2ccccc2c2ccccc21 CHEMBL1213099 IC50 300.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NC[C@@H]2c1ccc(F)cc1)c1cc2ccccc2[nH]1 CHEMBL4436548 IC50 320.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NC[C@@H]2c1ccc(F)cc1)NC(=O)C#Cc1ccccc1 CHEMBL4591820 IC50 320.0 nM
C[C@@H]1CN(C(=O)[C@H](C)N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CCN1 CHEMBL5080871 IC50 320.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccc(Cl)cc1)c1cc2cc(F)ccc2[nH]1 CHEMBL1254081 IC50 335.0 nM
C[C@@H](C(=O)N1CCNC(C)(C)C1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 CHEMBL5081973 IC50 360.0 nM
O=C(CSc1ccccc1)NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1 CHEMBL1213192 IC50 380.0 nM
C[C@@H](C(=O)N1CCOCC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 CHEMBL5093394 IC50 380.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccc(F)c(F)c1)c1cc2cc(F)ccc2[nH]1 CHEMBL1255081 IC50 390.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NC[C@@H]2c1ccc(F)cc1)c1cnc2ccccc2c1 CHEMBL4109224 IC50 450.0 nM
O=C(NCCN1CC2CC(n3c(=O)[nH]c4ccccc43)CC2C1)c1ccc(Br)cc1 CHEMBL3357318 IC50 468.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NC[C@@H]2c1ccc(F)cc1)c1ccc(F)cc1 CHEMBL4109788 IC50 480.0 nM
C[C@@H](CN1CCC2(CC1)CC(=O)Nc1ccccc12)NC(=O)c1ccc(F)cc1 CHEMBL5090919 IC50 490.0 nM
CC1CC(n2c(=O)[nH]c3ccccc32)CCN1CCNC(=O)c1ccc(F)cc1 CHEMBL3357313 IC50 636.0 nM
C[C@H](CN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)NC(=O)c1ccc(F)cc1 CHEMBL2325483 IC50 760.0 nM
O=C(NCCN1CC2CC(n3c(=O)[nH]c4ccccc43)CC2C1)c1ccc(F)c(F)c1 CHEMBL3357321 IC50 820.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NC[C@H]2c1ccc(F)cc1)NC(=O)c1ccc2ccccc2c1 CHEMBL4594070 IC50 820.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1ccccc1Cl CHEMBL1213191 IC50 870.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1cccc(Cl)c1)c1cnc2ccccc2c1 CHEMBL1254822 IC50 870.0 nM
O=C(NCCN1CC2CC(n3c(=O)[nH]c4ccccc43)CC2C1)c1ccc(F)cc1 CHEMBL3357317 IC50 870.0 nM
C[C@@H](CN1CCC(c2n[nH]c3ccccc23)CC1)NC(=O)c1ccc(F)cc1 CHEMBL5085765 IC50 970.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1ccc2ccccc2c1 CHEMBL511475 IC50 1000.0 nM
COc1ccc(C(=O)NCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)cc1 CHEMBL1213098 IC50 1000.0 nM