O=C(NCCN1CCC2(CC1)C(=O)NC[C@H]2c1ccc(F)cc1)c1cc2ccccc2[nH]1 CHEMBL4475943 IC50 2.5 nM
C[C@@H](CN1CCC2(CC1)C(=O)NC[C@H]2c1ccc(F)cc1)NC(=O)c1cc2ccccc2[nH]1 CHEMBL4453586 IC50 12.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccc(F)cc32)CC1)c1ccc(F)c(F)c1 CHEMBL492972 IC50 14.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1cc2cc(F)ccc2[nH]1 CHEMBL398567 IC50 17.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1cc2ccccc2[nH]1 CHEMBL246240 IC50 20.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)c1ccc2ccccc2c1 CHEMBL1254577 IC50 20.0 nM
Cc1cccc(N2CNC(=O)C23CCN(C[C@H](C)NC(=O)c2ccc(Br)cc2)CC3)c1 CHEMBL2325485 IC50 20.0 nM
O=C(NCCN1CCC2(CC1)CNC(=O)N2c1cccc(F)c1)c1ccc2ccccc2c1 CHEMBL3925090 IC50 20.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)NC(=O)c1ccc(Br)cc1 CHEMBL4446255 IC50 20.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)c1cc2cc(F)ccc2[nH]1 CHEMBL1254736 IC50 25.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NC[C@H]2c1ccc(F)cc1)NC(=O)c1ccc2ccccc2c1 CHEMBL4594070 IC50 26.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1cc2ccccc2s1 CHEMBL471257 IC50 30.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccc(F)cc1)c1cc2cc(F)ccc2[nH]1 CHEMBL1253900 IC50 30.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)NC(=O)c1ccc(F)cc1 CHEMBL2325482 IC50 35.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccc(F)cc1)c1cnc2ccccc2c1 CHEMBL1253820 IC50 40.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1cnc2ccccc2c1 CHEMBL246032 IC50 42.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccc(F)cc32)CC1)c1ccc(Cl)cc1 CHEMBL492971 IC50 42.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NC[C@@H]2c1ccc(F)cc1)c1cc2ccccc2[nH]1 CHEMBL4436548 IC50 43.0 nM
CCC(=C(c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1 CHEMBL2137046 IC50 44.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccc(Cl)cc1)c1cc2cc(F)ccc2[nH]1 CHEMBL1254081 IC50 50.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)NC(=O)c1ccc2ccccc2c1 CHEMBL1254495 IC50 60.0 nM
O=C(NCCN1CCC2(CC1)C(O)=NC[C@H]2c1ccc(F)cc1)c1cnc2ccccc2c1 CHEMBL3923136 IC50 60.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3cc(F)ccc32)CC1)c1ccc(Cl)cc1 CHEMBL523162 IC50 61.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)c1cnc2ccccc2c1 CHEMBL1254653 IC50 63.0 nM
C[C@@H](CN1CCC2(CC1)OC(=O)NC[C@H]2c1cccc(F)c1)NC(=O)c1ccc(F)cc1 CHEMBL5085284 IC50 64.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1cccc(Cl)c1)c1ccc(F)cc1 CHEMBL1254823 IC50 70.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccc(F)c(F)c1)c1cnc2ccccc2c1 CHEMBL1254996 IC50 70.0 nM
O=C(C#Cc1ccccc1)NCCN1CCC2(CC1)C(=O)NC[C@H]2c1ccc(F)cc1 CHEMBL4515874 IC50 70.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1cccc(Cl)c1)c1cc2cc(F)ccc2[nH]1 CHEMBL1254908 IC50 73.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3cc(Br)ccc32)CC1)c1ccc(F)cc1 CHEMBL521990 IC50 76.0 nM
COc1cc(C(=O)NCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)cc(OC)c1OC CHEMBL1213144 IC50 79.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccc(F)cc1)c1ccc2ccccc2c1 CHEMBL1255082 IC50 80.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1ccc2ccccc2n1 CHEMBL471054 IC50 90.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3cc(Br)ccc32)CC1)c1ccc(Cl)cc1 CHEMBL492561 IC50 97.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccc(F)c(F)c1)c1cc2cc(F)ccc2[nH]1 CHEMBL1255081 IC50 100.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccc(Br)cc1)c1cc2cc(F)ccc2[nH]1 CHEMBL1254176 IC50 100.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1ccc2ccccc2c1 CHEMBL511475 IC50 110.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NC[C@H]2c1ccc(F)cc1)NC(=O)c1cnc2ccccc2c1 CHEMBL4570440 IC50 115.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccc(F)c(F)c1)c1ccc2ccccc2c1 CHEMBL1254909 IC50 120.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)NC(=O)c1ccc(F)c(F)c1 CHEMBL2325487 IC50 120.0 nM
O=C(NCCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)cc1 CHEMBL1213097 IC50 130.0 nM
O=C(NCCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(F)c(F)c1 CHEMBL1213067 IC50 130.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3cc(F)ccc32)CC1)c1ccc2ccccc2c1 CHEMBL493010 IC50 140.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NCN2c1ccccc1)NC(=O)c1ccc2ccccc2c1 CHEMBL471056 IC50 140.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NC[C@@H]2c1ccc(F)cc1)NC(=O)c1cc2ccccc2[nH]1 CHEMBL4448918 IC50 140.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NC[C@H]2c1ccc(F)cc1)NC(=O)C#Cc1ccccc1 CHEMBL4514153 IC50 150.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1cccc(Cl)c1)c1cnc2ccccc2c1 CHEMBL1254822 IC50 165.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1cc(Br)c(Br)o1 CHEMBL1213066 IC50 170.0 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(Br)ccc32)CC1)NC(=O)c1ccc(F)c(F)c1 CHEMBL492559 IC50 187.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NCN2c1ccccc1)NC(=O)c1ccc(F)c(F)c1 CHEMBL511648 IC50 200.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccc(Cl)cc1)c1cnc2ccccc2c1 CHEMBL1253988 IC50 200.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)c1ccc(Br)cc1 CHEMBL2325484 IC50 200.0 nM
C[C@@H]1CN(C(=O)[C@H](C)N2CCC(n3c(=O)[nH]c4ccccc43)CC2)C[C@H](C)N1 CHEMBL5092677 IC50 200.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1cc2ccccc2s1 CHEMBL398568 IC50 210.0 nM
Cc1ccc(C(=O)NCCN2CCC(n3c(O)nc4ccccc43)CC2)cc1 CHEMBL1213140 IC50 210.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NC[C@H]2c1ccc(F)cc1)NC(=O)c1ccc(F)cc1 CHEMBL4581260 IC50 210.0 nM
O=C(NCCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 CHEMBL1213069 IC50 220.0 nM
O=C(NCCN1CCC2(CC1)C(O)=NC[C@H]2c1ccc(F)cc1)c1ccc(F)cc1 CHEMBL3983405 IC50 220.0 nM
C[C@@H]1CN(C(=O)[C@H](C)N2CCC(n3c(=O)[nH]c4ccccc43)CC2)C[C@@H](C)N1 CHEMBL5085809 IC50 230.0 nM
Cc1ccc(C(=O)NCCN2CCC(n3c(=O)[nH]c4cc(Cl)ccc43)CC2)cc1 CHEMBL494183 IC50 240.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1ccc2ccccc2c1 CHEMBL492797 IC50 240.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)n1c2ccccc2c2ccccc21 CHEMBL1213099 IC50 260.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1cccc(Cl)c1)c1ccc2ccccc2c1 CHEMBL1254737 IC50 290.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)c1ccc(F)cc1 CHEMBL245621 IC50 300.0 nM
C[C@@H]1CN(C(=O)[C@H](C)N2CCC(n3c(=O)[nH]c4ccccc43)CC2)Cc2ccccc21 CHEMBL5074314 IC50 320.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1ccc[nH]1 CHEMBL1213143 IC50 340.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccc(Br)cc1)c1ccc2ccccc2c1 CHEMBL1254082 IC50 350.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)c1ccc(F)cc1 CHEMBL1254654 IC50 350.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)c1ccc(F)c(F)c1 CHEMBL1907089 IC50 355.0 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3ccc(F)cc32)CC1)NC(=O)c1ccc2ccccc2c1 CHEMBL493521 IC50 360.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccc(Br)cc1)c1cnc2ccccc2c1 CHEMBL1254576 IC50 360.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2Cc1cccnc1)c1ccc2ccccc2c1 CHEMBL3580438 IC50 360.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3cc(F)ccc32)CC1)c1ccc(F)cc1 CHEMBL492369 IC50 375.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1ccco1 CHEMBL1213141 IC50 450.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NC[C@@H]2c1ccc(F)cc1)c1cnc2ccccc2c1 CHEMBL4109224 IC50 450.0 nM
O=C(c1ccc(F)cc1)N(CCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)C(=O)c1ccc(F)cc1 CHEMBL1213100 IC50 470.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)C1C[C@@H]1c1ccccc1 CHEMBL2304616 IC50 520.0 nM
COc1cc(C(=O)NCCN2CCC3(CC2)C(=O)NCN3c2ccccc2)ccc1N CHEMBL471261 IC50 550.0 nM
O=C(NCCN1CCC(n2c(O)nc3ccccc32)CC1)c1cccc2c1-c1ccccc1C2=O CHEMBL1213068 IC50 600.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccc(F)cc1)c1ccc(F)cc1 CHEMBL1253821 IC50 610.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccc(Cl)cc1)c1ccc2ccccc2c1 CHEMBL1253901 IC50 655.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccc(F)c(F)c1)c1ccc(F)cc1 CHEMBL1254997 IC50 660.0 nM
C[C@@H](CN1CCC2(CC1)C(=O)NC[C@@H]2c1ccc(F)cc1)NC(=O)c1cnc2ccccc2c1 CHEMBL3902347 IC50 700.0 nM
O=C(C#Cc1ccccc1)NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1 CHEMBL494007 IC50 730.0 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)NC(=O)c1ccc(F)c(F)c1 CHEMBL492558 IC50 730.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1ccc2ncccc2c1 CHEMBL494008 IC50 740.0 nM
C[C@H](CN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)NC(=O)c1ccc(Br)cc1 CHEMBL2325486 IC50 800.0 nM
O=C(C#Cc1ccccc1)NCCN1CCC2(CC1)C(=O)NC[C@@H]2c1ccc(F)cc1 CHEMBL4584012 IC50 810.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1ccc2cc(F)ccc2c1 CHEMBL495018 IC50 850.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)C1=CCc2ccccc2C1 CHEMBL494842 IC50 860.0 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(Br)ccc32)CC1)NC(=O)c1ccc(Cl)cc1 CHEMBL523011 IC50 890.0 nM
CC[C@H]1CN(C(=O)[C@H](C)N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CCN1 CHEMBL5088048 IC50 920.0 nM
C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)NC(=O)c1ccc2ccccc2c1 CHEMBL492572 IC50 933.0 nM
O=C(NCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)C1CCc2ccccc2C1 CHEMBL471258 IC50 990.0 nM
O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1ccsc1 CHEMBL246031 IC50 1000.0 nM
C[C@@H](CN1CCC2(CC1)OC(=O)Nc1cc(F)ccc12)NC(=O)c1ccc(F)cc1 CHEMBL5083605 IC50 1000.0 nM