COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(/C=C/c4ccc(CN5CCOCC5)cc4)n[nH]c3c1)C(=O)N2C CHEMBL3408945 Ki 0.1 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3[nH]ncc23)n[nH]1 CHEMBL5209160 IC50 0.1 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5185001 IC50 0.2 nM
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(/C=C/c4ccc(CN5C[C@@H](C)O[C@@H](C)C5)cc4)n[nH]c3c1)C(=O)N2 CHEMBL3408947 Ki 0.26 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)cc3)nc3[nH]ncc23)n[nH]1 CHEMBL5171469 IC50 0.3 nM
CC(=O)N1CCC(n2ncc3c(Nc4cc(C)[nH]n4)nc(NCc4ccc(Cl)c(C(=O)Nc5cc(F)ccc5F)c4)nc32)CC1 CHEMBL5428085 IC50 0.3 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4cc(F)ccc4F)c3)nc3[nH]ncc23)n[nH]1 CHEMBL5404983 IC50 0.3 nM
COc1ccc2c(c1)/C(=C\c1ccc3c(/C=C/c4ccc(CN(C)C)cc4)n[nH]c3c1)C(=O)N2 CHEMBL2407898 IC50 0.32 nM
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(/C=C/c4ccc(CN(C)C)cc4)n[nH]c3c1)C(=O)N2 CHEMBL3353348 IC50 0.37 nM
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(/C=C/c4ccc(CN5[C@H](C)CN(C)C[C@@H]5C)cc4)n[nH]c3c1)C(=O)N2 CHEMBL3408955 IC50 0.39 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4cc(F)ccc4F)c3)nc3c2cnn3C2CCS(=O)(=O)CC2)n[nH]1 CHEMBL5439790 IC50 0.4 nM
COc1ccc2c(c1)/C(=C\c1ccc3c(/C=C/c4ccncc4)n[nH]c3c1)C(=O)N2 CHEMBL2407894 IC50 0.45 nM
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(-c4ccc(N5CCNCC5)cc4)n[nH]c3c1)C(=O)N2 CHEMBL4553351 IC50 0.45 nM
COc1ccc2c(c1)/C(=C\c1ccc3c(/C=C/c4cccnc4)n[nH]c3c1)C(=O)N2 CHEMBL2407748 IC50 0.48 nM
CN(C)Cc1ccc(/C=C/c2n[nH]c3cc([C@@H]4C[C@@]45C(=O)Nc4ccccc45)ccc23)cc1 CHEMBL3353347 IC50 0.59 nM
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(/C=C/c4ccc(CN5CCCCC5)cc4)n[nH]c3c1)C(=O)N2 CHEMBL3408944 IC50 0.6 nM
COc1ccc2c(c1)/C(=C\c1ccc3c(/C=C/c4ccc(N5CCN(C)CC5)nc4)n[nH]c3c1)C(=O)N2 CHEMBL2407900 IC50 0.61 nM
C[C@@H]1CN(Cc2ccc(/C=C/c3n[nH]c4cc([C@@H]5C[C@@]56C(=O)Nc5ccccc56)ccc34)cc2)C[C@H](C)N1C CHEMBL3408954 IC50 0.64 nM
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(-c4ccc(N5CCN(C)CC5)nc4)n[nH]c3c1)C(=O)N2 CHEMBL4516793 IC50 0.69 nM
Cc1cc(Nc2nc(NCc3ccccc3Cl)nc3[nH]ncc23)n[nH]1 CHEMBL5171233 IC50 0.7 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCNCC2)n[nH]1 CHEMBL5188129 IC50 0.7 nM
CCc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5183346 IC50 0.7 nM
Cc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(/C=C/c4ccc(CN(C)C)cc4)n[nH]c3c1)C(=O)N2 CHEMBL3353351 IC50 0.71 nM
C[C@@H]1CN(Cc2ccc(/C=C/c3n[nH]c4cc([C@@H]5C[C@@]56C(=O)Nc5ccccc56)ccc34)cc2)C[C@H](C)O1 CHEMBL3408946 Ki 0.73 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 Kd 0.75 nM
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(/C=C/c4ccc(N5CCN(C)CC5)nc4)n[nH]c3c1)C(=O)N2 CHEMBL3353341 IC50 0.75 nM
CN(C)Cc1ccc(/C=C/c2n[nH]c3cc([C@@H]4C[C@@]45C(=O)Nc4ccc(F)cc45)ccc23)cc1 CHEMBL3353352 IC50 0.79 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3)nc3[nH]ncc23)n[nH]1 CHEMBL5200865 IC50 0.8 nM
O=C1Nc2ccccc2/C1=C\c1ccc2c(/C=C/c3ccc(C(=O)O)cc3)n[nH]c2c1 CHEMBL2407744 IC50 0.82 nM
O=C1Nc2ccc(O)cc2/C1=C\c1ccc2c(/C=C/c3ccncc3)n[nH]c2c1 CHEMBL2407895 IC50 0.9 nM
O=C1Nc2ccccc2[C@]12C[C@H]2c1ccc2c(/C=C/c3ccc(N4CCNCC4)cc3)n[nH]c2c1 CHEMBL3408941 IC50 0.9 nM
O=C1Nc2ccccc2[C@]12C[C@H]2c1ccc2c(/C=C/c3ccc(CN4CCCC4)cc3)n[nH]c2c1 CHEMBL3353361 IC50 0.9 nM
O=C1Nc2ccccc2[C@]12C[C@H]2c1ccc2c(/C=C/c3ccc(CN4CCCCC4)cc3)n[nH]c2c1 CHEMBL3353362 IC50 0.9 nM
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(/C=C/c4ccc(CN5CCOCC5)cc4)n[nH]c3c1)C(=O)N2 CHEMBL3353355 IC50 0.9 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4cc(F)ccc4F)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5402864 IC50 0.9 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 0.93 nM
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(-c4ccc(N5CCN(C)CC5)cc4)n[nH]c3c1)C(=O)N2 CHEMBL4448596 IC50 0.94 nM
Cc1cc(Nc2nc(NCc3ccccc3F)nc3[nH]ncc23)n[nH]1 CHEMBL5185324 IC50 1.0 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4cc(F)ccc4F)c3)nc3c2cnn3C2CCN(S(C)(=O)=O)CC2)n[nH]1 CHEMBL5420150 IC50 1.0 nM
CN1CCC(Oc2ccc(/C=C/c3n[nH]c4cc([C@@H]5C[C@@]56C(=O)Nc5ccccc56)ccc34)cc2)CC1 CHEMBL3408956 IC50 1.1 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C(C)C)n[nH]1 CHEMBL5194020 IC50 1.1 nM
CN(C)Cc1ccc(/C=C/c2n[nH]c3cc([C@@H]4C[C@@]45C(=O)Nc4ccc(Cl)cc45)ccc23)cc1 CHEMBL3353350 IC50 1.2 nM
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(-c4ccc(N5C[C@@H](C)N[C@@H](C)C5)cc4)n[nH]c3c1)C(=O)N2 CHEMBL4440053 IC50 1.2 nM
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(-c4ccc(N5CCN(CCO)CC5)cc4)n[nH]c3c1)C(=O)N2 CHEMBL4470693 IC50 1.2 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4cc(F)ccc4F)c3)nc3c2cnn3C)n[nH]1 CHEMBL5432542 IC50 1.2 nM
CN1CCN(c2ccc(/C=C/c3n[nH]c4cc([C@@H]5C[C@@]56C(=O)N(C)c5ccccc56)ccc34)cn2)CC1 CHEMBL3408940 IC50 1.3 nM
CN1CCN(c2ccc(/C=C/c3n[nH]c4cc(/C=C5/C(=O)Nc6ccccc65)ccc34)cn2)CC1 CHEMBL2407899 IC50 1.4 nM
Cc1ccc2c(c1)/C(=C\c1ccc3c(/C=C/c4ccncc4)n[nH]c3c1)C(=O)N2 CHEMBL2407893 IC50 1.4 nM
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(/C=C/c4ccc(CN5CCCCC5)nc4)n[nH]c3c1)C(=O)N2 CHEMBL3353346 IC50 1.4 nM
CN(C)Cc1ccc(/C=C/c2n[nH]c3cc([C@@H]4C[C@@]45C(=O)N(C)c4ccccc45)ccc23)cc1 CHEMBL3408942 IC50 1.4 nM
O=C1Nc2ccccc2[C@]12C[C@H]2c1ccc2c(/C=C/c3ccc(CN4CCOCC4)cc3)n[nH]c2c1 CHEMBL3353354 IC50 1.4 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 1.5 nM
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(/C=C/c4ccc([C@H](C)N5CCOCC5)cc4)n[nH]c3c1)C(=O)N2C CHEMBL3408951 IC50 1.5 nM
CC(C)N1CCC(Oc2ccc(/C=C/c3n[nH]c4cc([C@@H]5C[C@@]56C(=O)Nc5ccccc56)ccc34)cc2)CC1 CHEMBL3408957 IC50 1.5 nM
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(-c4ccc(C5(F)CCN(C)CC5)cc4)n[nH]c3c1)C(=O)N2 CHEMBL4437913 IC50 1.5 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)CCCOc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)n[nH]1 CHEMBL5408998 IC50 1.5 nM
CCc1ccc2c(c1)/C(=C\c1ccc3c(/C=C/c4cccnc4)n[nH]c3c1)C(=O)N2 CHEMBL2407747 IC50 1.6 nM
O=C1Nc2ccccc2[C@]12C[C@H]2c1ccc2c(/C=C/c3cccnc3)n[nH]c2c1 CHEMBL3353342 IC50 1.6 nM
CCN1CCN(c2ccc(-c3n[nH]c4cc([C@@H]5C[C@@]56C(=O)Nc5ccc(OC)cc56)ccc34)cc2)CC1 CHEMBL4440812 IC50 1.6 nM
O=C1Nc2ccccc2[C@]12C[C@H]2c1ccc2c(/C=C/c3ccc(CN4CCCOCC4)cc3)n[nH]c2c1 CHEMBL3408953 IC50 1.7 nM
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(-c4ccc(N5CCC(O)CC5)nc4)n[nH]c3c1)C(=O)N2 CHEMBL4461353 IC50 1.7 nM
CCN(CC)Cc1ccc(/C=C/c2n[nH]c3cc([C@@H]4C[C@@]45C(=O)Nc4ccccc45)ccc23)cc1 CHEMBL3353360 IC50 1.8 nM
Fc1ccc(CNc2nc(Nc3cc(C4CC4)[nH]n3)c3cnn(C4CCOCC4)c3n2)c(F)c1 CHEMBL5191641 IC50 1.8 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)COCCOc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)n[nH]1 CHEMBL5430165 IC50 1.9 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(C)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1984162 pKi 1.995 nM
CN(C)Cc1ccc(/C=C/c2n[nH]c3cc(/C=C4/C(=O)Nc5ccccc54)ccc23)cc1 CHEMBL2407897 IC50 2.0 nM
O=C1Nc2ccccc2/C1=C\c1ccc2c(/C=C/c3cccnc3)n[nH]c2c1 CHEMBL2407746 IC50 2.0 nM
CCc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(/C=C/c4ccc(CN(C)C)cc4)n[nH]c3c1)C(=O)N2 CHEMBL3353353 IC50 2.0 nM
O=C1Nc2ccccc2[C@]12C[C@H]2c1ccc2c(/C=C/c3ccc(CN4CCCCC4)nc3)n[nH]c2c1 CHEMBL3353345 IC50 2.0 nM
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(-c4ccnc(N5CCN(C)CC5)c4)n[nH]c3c1)C(=O)N2 CHEMBL4457197 IC50 2.1 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4cccc(F)c4)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5424463 IC50 2.1 nM
O=C1Nc2ccc(Cl)cc2/C1=C\c1ccc2c(/C=C/c3ccncc3)n[nH]c2c1 CHEMBL2407750 IC50 2.3 nM
CN1CCN(Cc2ccc(/C=C/c3n[nH]c4cc([C@@H]5C[C@@]56C(=O)Nc5ccccc56)ccc34)cc2)CC1 CHEMBL3353359 IC50 2.4 nM
O=C1Nc2ccccc2/C1=C\c1ccc2c(/C=C/c3ccncc3)n[nH]c2c1 CHEMBL2407749 IC50 2.4 nM
COc1ccc2c(c1)C(=Cc1ccc3c(-c4ccc(N5CCN(C)CC5)nc4)n[nH]c3c1)C(=O)N2 CHEMBL4434704 IC50 2.4 nM
CN(C)Cc1ccc(/C=C/c2n[nH]c3cc([C@@H]4C[C@@]45C(=O)Nc4ccc(OC(F)F)cc45)ccc23)cc1 CHEMBL3353349 IC50 2.6 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)CCCCOc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)n[nH]1 CHEMBL5407696 IC50 2.6 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4cc(F)ccc4F)c3)nc3c2cnn3C(C)C)n[nH]1 CHEMBL5404721 IC50 2.6 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3CC(C)(C)O)n[nH]1 CHEMBL5176789 IC50 2.7 nM
COc1c(Nc2cc(C)[nH]n2)nc(Sc2ccc(S(=O)(=O)Cc3cccc([N+](=O)[O-])c3F)cc2F)nc1N1CCOCC1 CHEMBL5185225 IC50 2.7 nM
CC(C)c1cc(CNc2nc(Nc3cc(C4CC4)[nH]n3)cc(N3CCN(C)CC3)n2)on1 CHEMBL3545085 Kd apparent 3.0 nM
Cc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(/C=C/c4ccc(CN5CCOCC5)cc4)n[nH]c3c1)C(=O)N2 CHEMBL3353357 IC50 3.1 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(CC3CCN(c4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)n[nH]1 CHEMBL5422518 IC50 3.1 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 3.162 nM
Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCC#N)c4c21)CNC3=O CHEMBL302449 Ki 3.4 nM
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(/C=C/c4cc(F)c(CN5CCOCC5)c(F)c4)n[nH]c3c1)C(=O)N2 CHEMBL3353358 IC50 3.4 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 3.5 nM
O=C1Nc2ccccc2[C@]12C[C@H]2c1ccc2c(/C=C/c3ccncc3)n[nH]c2c1 CHEMBL3353340 IC50 3.6 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)CCOCCOc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)n[nH]1 CHEMBL5440306 IC50 3.6 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)cc3)nc3c2cnn3C(C)C)n[nH]1 CHEMBL5190548 IC50 3.7 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4cc(F)cc(F)c4)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5426828 IC50 3.7 nM
O=C1Nc2ccccc2[C@]12C[C@H]2c1ccc2c(/C=C/c3ccc(CN4CC[C@@H](F)C4)cc3)n[nH]c2c1 CHEMBL3408943 IC50 3.8 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)cc3)nc3c2cnn3CC(C)(C)O)n[nH]1 CHEMBL5207473 IC50 3.8 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl CHEMBL458997 pKi 3.981 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)cc3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5201909 IC50 4.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 4.2 nM
CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL1289926 Ki 4.2 nM
Cc1ccc(/C=C/c2n[nH]c3cc([C@@H]4C[C@@]45C(=O)Nc4ccccc45)ccc23)cn1 CHEMBL3353343 IC50 4.6 nM
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(-c4ccc(N5CCOCC5)nc4)n[nH]c3c1)C(=O)N2 CHEMBL4590185 IC50 4.6 nM
O=C1Nc2ccc(F)cc2[C@]12C[C@H]2c1ccc2c(/C=C/c3ccc(CN4CCOCC4)cc3)n[nH]c2c1 CHEMBL3353356 IC50 4.9 nM
CO[C@@H](C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 CHEMBL402548 Kd apparent 5.0 nM
O=C1Nc2ccccc2[C@]12C[C@H]2c1ccc2c(/C=C/c3ccc(CN4CC5CCC(C4)O5)cc3)n[nH]c2c1 CHEMBL3408952 IC50 5.2 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4ccccc4)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5397250 IC50 5.4 nM
Cc1cc(Nc2nc(NCc3cccc(Cl)c3)nc3[nH]ncc23)n[nH]1 CHEMBL5175294 IC50 5.5 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)CCCCCOc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)n[nH]1 CHEMBL5396625 IC50 5.5 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)C3CCN(c4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)CC2)n[nH]1 CHEMBL5433109 IC50 5.5 nM
Cc1cc(Nc2nc(NCc3ccc(Br)cc3)nc3[nH]ncc23)n[nH]1 CHEMBL5187941 IC50 5.6 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)COc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)n[nH]1 CHEMBL5405221 IC50 5.6 nM
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(/C=C/c4ccc(CN5C[C@@H](C)O[C@@H](C)C5)cc4)n[nH]c3c1)C(=O)N2C CHEMBL3408948 IC50 5.7 nM
CN1CCN(c2ccc(-c3n[nH]c4cc([C@@H]5C[C@@]56C(=O)Nc5ccc(F)cc56)ccc34)cn2)CC1 CHEMBL4475381 IC50 5.9 nM
Cc1ccc(/C=C/c2n[nH]c3cc([C@@H]4C[C@@]45C(=O)Nc4ccccc45)ccc23)c(C)n1 CHEMBL3353344 IC50 6.3 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 6.31 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 6.31 nM
COC(C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 CHEMBL1981047 pKi 6.31 nM
COc1ccc(CNc2nc(Nc3cc(C)[nH]n3)c3cn[nH]c3n2)cc1 CHEMBL5198607 IC50 6.5 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4cccc(Cl)c4)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5435158 IC50 6.7 nM
CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(-c4ccncc4)cc3)n2)c(=O)c1=O CHEMBL2205426 Ki 7.0 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)cc3)nc3c2cnn3C2CCNCC2)n[nH]1 CHEMBL5200125 IC50 7.0 nM
COc1cc2c(cc1F)C(c1ccccc1Cl)=Nc1c(n[nH]c1C)N2 CHEMBL1980391 IC50 7.0 nM
Nc1ccc(Sc2ccnc(Nc3ccc(NC4CCOCC4)cc3)n2)cc1 CHEMBL5430526 IC50 7.0 nM
O=C1Nc2ccccc2[C@]12C[C@H]2c1ccc2c(/C=C/c3cccc(CN4CCOCC4)c3)n[nH]c2c1 CHEMBL3408949 IC50 7.6 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL572878 Ki 7.66 nM
Cc1cc(Nc2cc(N3CCN(N)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL5407522 Ki 7.66 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCCCC2)n[nH]1 CHEMBL5180759 IC50 7.9 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL244378 pKi 7.943 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCNS(C)(=O)=O)cnc(N)c34)cc2)c1 CHEMBL1994321 pKi 7.943 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 7.943 nM
COc1ccc(Nc2nccc(Nc3c(NC(C)C(C)(C)C)c(=O)c3=O)n2)cc1OC CHEMBL1964399 pKi 7.943 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)CC3CCN(c4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)CC2)n[nH]1 CHEMBL5434630 IC50 8.1 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)C3CCN(c4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)n[nH]1 CHEMBL5410922 IC50 8.4 nM
Cc1cc(Nc2nc(NC(C)c3ccc(Cl)c(C(=O)Nc4cc(F)ccc4F)c3)nc3c2cnn3C(C)C)n[nH]1 CHEMBL5397303 IC50 8.6 nM
Cc1cc(Nc2nc(NCc3ccccc3Br)nc3[nH]ncc23)n[nH]1 CHEMBL5208535 IC50 8.7 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(NC(C)CO)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5430106 IC50 8.9 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)CCCCCCOc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)n[nH]1 CHEMBL5422161 IC50 9.1 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4ccccc4F)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5438019 IC50 9.3 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)COCCOCCOc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)n[nH]1 CHEMBL5430793 IC50 9.4 nM
COc1cccc(NC(=O)c2cc(CNc3nc(Nc4cc(C)[nH]n4)c4cnn(C5CCOCC5)c4n3)ccc2Cl)c1 CHEMBL5401850 IC50 9.7 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 10.0 nM
Nc1ncnc2scc(C(=O)Nc3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL1988594 pKi 10.0 nM
Cc1ccccc1NC(=O)Nc1ccc(NC(=O)c2csc3ncnc(N)c23)cc1 CHEMBL1980144 pKi 10.0 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 pKi 10.0 nM
C[C@@]1(C(=O)Nc2ccc(F)nc2)CCCN1c1nc(Nc2cc(C3CC3)n[nH]2)c2cccn2n1 CHEMBL575448 Kd apparent 10.0 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(CC3CN(c4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)CC2)n[nH]1 CHEMBL5397330 IC50 10.1 nM
Cc1cc(Nc2nc(NCc3ccc(C#N)cc3)nc3[nH]ncc23)n[nH]1 CHEMBL5175172 IC50 10.5 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4cccc(F)c4F)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5429187 IC50 10.5 nM
Cc1cc(Nc2nc(NCc3ccc4c(c3)NCCO4)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5411040 IC50 11.6 nM
Cc1cc(N2CCOCC2)cc2[nH]c(-c3c(NCC(O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL2005886 pKi 12.59 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)c1 CHEMBL1967116 pKi 12.59 nM
Cc1cccc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)c1 CHEMBL1965507 pKi 12.59 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)cc1C CHEMBL2000335 pKi 12.59 nM
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1973540 pKi 12.59 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 12.59 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 12.59 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)CC3CN(c4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)CC2)n[nH]1 CHEMBL5435948 IC50 12.9 nM
O=C1Nc2ccccc2/C1=C\c1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL2407745 IC50 13.0 nM
CN1CCN(c2ccc(-c3n[nH]c4cc(C=C5C(=O)Nc6ccccc65)ccc34)cn2)CC1 CHEMBL4437872 IC50 13.0 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(CC3CCN(c4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)CC2)n[nH]1 CHEMBL5438607 IC50 13.6 nM
Cc1cc(Nc2nc(NCc3cccc(F)c3)nc3[nH]ncc23)n[nH]1 CHEMBL5199896 IC50 14.6 nM
CNC(=O)C(C)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(C)cc5)cc4)csc23)cn1 CHEMBL1970142 pKi 15.85 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1970317 pKi 15.85 nM
Cc1ccc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)cc1 CHEMBL1972576 pKi 15.85 nM
Cc1cccc(Nc2nccc(Nc3c(NC(C)C(C)(C)C)c(=O)c3=O)n2)c1 CHEMBL1969523 pKi 15.85 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(NC4CCOC4)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5418250 IC50 15.9 nM
Nc1ccc(Sc2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL5396704 IC50 17.0 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C)n[nH]1 CHEMBL5169342 IC50 17.5 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1 CHEMBL3301622 Kd apparent 18.0 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]nc(-c5cc(F)cc(NC(=O)Nc6cncnc6)c5)c4c3)cc2)CC1 CHEMBL5399402 IC50 18.0 nM
Cc1cc(Nc2nc(NCc3cc(C(=O)Nc4cc(F)ccc4F)c(Cl)cn3)nc3c2cnn3C(C)C)n[nH]1 CHEMBL5432162 IC50 18.2 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)C3CN(c4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)CC2)n[nH]1 CHEMBL5435903 IC50 18.9 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)CC3CCN(c4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)n[nH]1 CHEMBL5413470 IC50 19.1 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4ccccc4Cl)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5409434 IC50 19.5 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)CCCCCCCCCCCCCCCCCOc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)n[nH]1 CHEMBL5438512 IC50 19.6 nM
CCc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4cc(F)ccc4F)c3)nc3c2cnn3C(C)C)n[nH]1 CHEMBL5396900 IC50 19.9 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 19.95 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)c1 CHEMBL1970203 pKi 19.95 nM
CNC(=O)c1ccccc1Sc1ccc2c(C=Cc3ccccn3)n[nH]c2c1 CHEMBL1988437 pKi 19.95 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(O)c2)n1 CHEMBL243088 pKi 19.95 nM
C[C@@H]1CN(Cc2cccc(/C=C/c3n[nH]c4cc([C@@H]5C[C@@]56C(=O)Nc5ccccc56)ccc34)c2)C[C@H](C)O1 CHEMBL3408950 IC50 20.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 20.0 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)cc3)nc3c2cnn3C)n[nH]1 CHEMBL5183478 IC50 20.2 nM
Cc1cnc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCOCC2)s1 CHEMBL5200812 IC50 20.7 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 21.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 21.0 nM
Cc1cc(Nc2nc(NCc3ccccc3)nc3[nH]ncc23)n[nH]1 CHEMBL5179518 IC50 21.2 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4ccc(F)c(F)c4)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5425999 IC50 21.5 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(NCCS(C)(=O)=O)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5433434 IC50 21.6 nM
O=C1Nc2ccccc2/C1=C\c1ccc2cn[nH]c2c1 CHEMBL2407911 Ki(app) 22.0 nM
CC(=O)Nc1nccc(-c2ccc3c(/C=C/c4ccc(CN(C)C)cc4)n[nH]c3c2)n1 CHEMBL5173724 IC50 22.0 nM
Cc1cc(Nc2nc(NCc3ccc(F)c(F)c3)nc3[nH]ncc23)n[nH]1 CHEMBL5198928 IC50 22.2 nM
Cc1cc(Nc2nc(NCc3cccc(Br)c3)nc3[nH]ncc23)n[nH]1 CHEMBL5181286 IC50 23.3 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4ccc(F)cc4)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5424704 IC50 23.4 nM
COCCN(C)c1cc(CNc2nc(Nc3cc(C)[nH]n3)c3cnn(C4CCOCC4)c3n2)ccc1Cl CHEMBL5401624 IC50 23.7 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(NC4CCOCC4)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5415864 IC50 24.2 nM
Cc1cc(Nc2nc(NCc3ccc(F)c(NC(C)CO)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5425790 IC50 24.2 nM
COCCOc1ccc2cc1OCC(=O)N(C)CCCN(C)Cc1c[nH]c3ncnc(c13)N2 CHEMBL2407901 Ki 25.0 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 pKi 25.12 nM
Fc1cnc(Nc2ccccc2)nc1Nc1ccccc1 CHEMBL491758 pKi 25.12 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)cc1 CHEMBL1982466 pKi 25.12 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(C=Cc3ccccc3)n2)n[nH]1 CHEMBL1983923 pKi 25.12 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(NC4CCS(=O)(=O)C4)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5413063 IC50 25.3 nM
COc1ccc(NC(=O)c2cc(CNc3nc(Nc4cc(C)[nH]n4)c4cnn(C5CCOCC5)c4n3)ccc2Cl)cc1OC CHEMBL5434198 IC50 25.4 nM
CS(=O)(=O)c1cccc(-c2cnc3[nH]nc(-c4cc(F)cc(NC(=O)Nc5cncnc5)c4)c3c2)c1 CHEMBL5421662 IC50 26.0 nM
Cc1cc(Nc2nc(NCc3ccc4c(c3)N(C)CCO4)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5438955 IC50 27.1 nM
O=C1Nc2ccccc2C1=Cc1ccc2c(-c3cccnc3)n[nH]c2c1 CHEMBL4579738 IC50 29.0 nM
COc1ccc2c(c1)[C@@]1(C[C@@H]1c1ccc3c(-c4ccc(N5CCN(C)CC5)nc4)n[nH]c3c1)C(=O)N2 CHEMBL4467348 IC50 30.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 31.0 nM
c1ccc(Sc2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL5418122 IC50 31.0 nM
O=C1NCCc2[nH]c(-c3ccnc(C=Cc4ccccc4)c3)cc21 CHEMBL1997129 pKi 31.62 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(OC(F)F)cc5)cc4)csc23)cn1 CHEMBL1988387 pKi 31.62 nM
Cn1cc(C2=Nc3cc(NC(=O)C(N)C4CCCCC4)cc4c3C2=CNNC4=O)cn1 CHEMBL3545137 Kd apparent 32.0 nM
Cc1cc(Nc2nc(NCc3ccc(F)c(NC4CCOC4)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5405656 IC50 32.1 nM
Cc1cc(Nc2nc(NCc3cnc(Cl)c(C(=O)Nc4cc(F)ccc4F)c3)nc3c2cnn3C(C)C)n[nH]1 CHEMBL5412525 IC50 32.8 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 33.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 33.0 nM
Nc1ccc(Sc2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)c(F)c1 CHEMBL5399061 IC50 35.0 nM
O=C(Nc1cncnc1)Nc1cc(F)cc(-c2n[nH]c3ncc(-c4ccc(CN5CCOCC5)cc4)cc23)c1 CHEMBL5401007 IC50 35.0 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)CCOCCOCCCOc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)n[nH]1 CHEMBL5402930 IC50 37.9 nM
Cc1cc(Nc2nc(NCc3ccc4c(c3)NCCCO4)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5430972 IC50 38.2 nM
Nc1ccc(Sc2ccnc(Nc3ccc(C(=O)N4CCOCC4)cc3)n2)cc1 CHEMBL5400742 IC50 39.0 nM
CC(O)Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL2002165 pKi 39.81 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3I)cc12 CHEMBL1975128 pKi 39.81 nM
CC(Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL1825138 pKi 39.81 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)csc12 CHEMBL1982476 pKi 39.81 nM
CCN(CC)CCNC(=O)C=Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL2004716 pKi 39.81 nM
CN1CCN(c2ccc(C(=O)Nc3n[nH]c4ccc(Cc5cc(F)cc(F)c5)cc34)c(NC3CCOCC3)c2)CC1 CHEMBL1983268 pKi 39.81 nM
O=C1NCc2c1cccc2-c1ccc(Nc2nc3ccccc3[nH]2)cc1 CHEMBL1979057 pKi 39.81 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc1)CCN2 CHEMBL260092 pKi 39.81 nM
COc1cc(Nc2ncc3c(n2)-c2ccc(Cl)cc2C(c2c(F)cccc2OC)=NC3)ccc1C(=O)O CHEMBL483158 pKi 39.81 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccccc1 CHEMBL1999931 pKi 39.81 nM
CCS(=O)(=O)c1cccc(-c2cc(C(=O)NC3CCN(C)CC3)c(C)c3[nH]c4ncc(C)cc4c23)c1 CHEMBL3544932 Kd apparent 41.0 nM
O=C1Nc2ccccc2/C1=C\c1ccc2c(/C=C/c3ccccc3)n[nH]c2c1 CHEMBL2407896 IC50 42.0 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)CCCCCCCOc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)n[nH]1 CHEMBL5397574 IC50 42.2 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(CC3CC4(C3)CN(c3ccc5c(c3)C(=O)N(C3CCC(=O)NC3=O)C5=O)C4)CC2)n[nH]1 CHEMBL5404385 IC50 42.3 nM
C=CC(=O)Nc1ccc(C(=O)Nc2ccc(Nc3ncc4c(n3)N(C)c3ccc(C)cc3C(=O)N4C)cc2)cc1 CHEMBL3969370 IC50 43.5 nM
Cc1cc(Nc2nc(NCc3ccc(F)c(NC4CCOCC4)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5411852 IC50 44.7 nM
Nc1ccc(Sc2ccnc(Nc3cccc(N4CCOCC4)c3)n2)cc1 CHEMBL5401427 IC50 45.0 nM
c1cc(Sc2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)c2cccnc2c1 CHEMBL5440788 IC50 46.0 nM
COc1ccc2c(c1)/C(=C\c1ccc3cn[nH]c3c1)C(=O)N2 CHEMBL2407916 IC50 47.0 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)cc3)nc3c2cnn3C2CCCCC2)n[nH]1 CHEMBL5192169 IC50 47.9 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4c(F)cccc4F)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4462318 Kd(free) 48.0 nM
O=C(Nc1cccc(Cl)c1)Nc1ncc(CCNc2ncnc3ccsc23)s1 CHEMBL482767 pKi 50.12 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN(C)C)cnc(N)c34)cc2)c1 CHEMBL1979883 pKi 50.12 nM
CCc1c(-c2ccc(C(C)(C)O)cc2)[nH]c2nccnc12 CHEMBL1976420 pKi 50.12 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(Cl)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1987054 pKi 50.12 nM
Nc1ncc(-c2ccncc2)c2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1970083 pKi 50.12 nM
CC(C)(C(N)=O)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1967720 pKi 50.12 nM
Cc1cccc(NC(=O)c2cc(CNc3nc(Nc4cc(C)[nH]n4)c4cnn(C5CCOCC5)c4n3)ccc2Cl)c1 CHEMBL5420791 IC50 51.4 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 53.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4cc(F)ccc4F)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4443828 Kd(free) 53.0 nM
O=C1Nc2ccc(Cl)cc2/C1=C\c1ccc2cn[nH]c2c1 CHEMBL2407914 IC50 54.0 nM
CN1CCN(c2ccc(-c3n[nH]c4cc([C@@H]5C[C@@]56C(=O)Nc5ccccc56)ccc34)cn2)CC1 CHEMBL4546145 IC50 54.0 nM
Nc1ccc(Sc2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1F CHEMBL5394505 IC50 56.0 nM
Nc1ccc(Sc2ccnc(Nc3ccc(NC4CCNCC4)cc3)n2)cc1 CHEMBL5417800 IC50 57.0 nM
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL601719 Kd 60.0 nM
O=C1Nc2ccc(F)cc2/C1=C\c1ccc2cn[nH]c2c1 CHEMBL2407912 IC50 60.0 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)CC3CC4(C3)CN(c3ccc5c(c3)C(=O)N(C3CCC(=O)NC3=O)C5=O)C4)CC2)n[nH]1 CHEMBL5423103 IC50 61.1 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4cccc(Br)c4)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5439446 IC50 61.2 nM
CCCn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1993941 pKi 63.1 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1998585 pKi 63.1 nM
CNC(=O)COc1ccc(Nc2nc(Nc3ccc(C)c(S(N)(=O)=O)c3)ncc2F)cc1 CHEMBL1978099 pKi 63.1 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)O)c5)cnc(N)c34)cc2)c1 CHEMBL1989708 pKi 63.1 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 63.1 nM
N#Cc1ncc2nc1OCCCCOc1cc(NCc3cncs3)c(Cl)cc1NC(=O)N2 CHEMBL248757 pKi 63.1 nM
CCN1CCN(c2ccc(Nc3nccc(-c4c(-c5cccc(C(=O)Nc6ccccc6F)c5)nc5ccccn45)n3)cc2)CC1 CHEMBL1981725 pKi 63.1 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN5CCOCC5)cnc(N)c34)cc2)c1 CHEMBL1982465 pKi 63.1 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)(C)O)c5)cnc(N)c34)cc2)cc1 CHEMBL2004290 pKi 63.1 nM
Cc1[nH]c(C=C2C(=O)Nc3ccccc32)c(C)c1CCC(=O)O CHEMBL2007064 pKi 63.1 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4cnc5ccccc5c4)c3)cc21 CHEMBL226403 pKi 63.1 nM
O=C1Nc2ccccc2C1=Cc1ccc2c(-c3ccc[nH]3)n[nH]c2c1 CHEMBL4449539 IC50 64.0 nM
Nc1ccc(Sc2ccnc(Nc3ccc(CN4CCOCC4)cc3)n2)cc1 CHEMBL5434779 IC50 64.0 nM
c1ccc(Nc2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL5423456 IC50 65.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 66.0 nM
O=C(Nc1cncnc1)Nc1cc(F)cc(-c2n[nH]c3ncc(-c4cccc(CN5CCOCC5)c4)cc23)c1 CHEMBL5404382 IC50 66.0 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 70.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncnc(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL3545360 Kd apparent 70.0 nM
CNc1ccc(Sc2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL5399219 IC50 71.0 nM
COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL281948 Kd apparent 73.0 nM
Cc1nc2c(F)cc(-c3n[nH]c4ncc(-c5cccc(S(C)(=O)=O)c5)cc34)cc2n1C(C)C CHEMBL5413962 IC50 73.0 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)C3CC4(C3)CN(c3ccc5c(c3)C(=O)N(C3CCC(=O)NC3=O)C5=O)C4)CC2)n[nH]1 CHEMBL5420682 IC50 75.2 nM
Cc1cc(Nc2nc(NCc3ccc(F)c(N4CCOCC4)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5429009 IC50 76.8 nM
CN1CCN(Cc2cccc(-c3cnc4[nH]nc(-c5cc(F)cc(NC(=O)Nc6cncnc6)c5)c4c3)c2)CC1 CHEMBL5416099 IC50 77.0 nM
Cc1cc(Nc2nc(NCc3c(F)cc(F)cc3F)nc3[nH]ncc23)n[nH]1 CHEMBL5187903 IC50 78.5 nM
Fc1cccc(Sc2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)c1 CHEMBL5395263 IC50 79.0 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C(C)C(=O)N(C)C)c5)cnc(N)c34)cc2)cc1 CHEMBL2001485 pKi 79.43 nM
COc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1OC CHEMBL1991078 pKi 79.43 nM
Cc1cc(Cl)ccc1NC(=S)NNC(=O)C(O)(c1ccccc1)c1ccccc1 CHEMBL1988173 pKi 79.43 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cn[nH]c5)cnc(N)c34)cc2)c1 CHEMBL1969102 pKi 79.43 nM
O=c1[nH]c2cnc(-n3cnc4ccc(F)cc43)nc2n1C1CCOc2c(F)cccc21 CHEMBL2000393 pKi 79.43 nM
COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(C(=O)O)s3)c2cc1OC CHEMBL474432 pKi 79.43 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)csc12 CHEMBL2005631 pKi 79.43 nM
Nc1ccc(Sc2ccnc(Nc3ccc(NC4CCNC4)cc3)n2)cc1 CHEMBL5429145 IC50 80.0 nM
c1ccc(Oc2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL5415559 IC50 81.0 nM
CCC(=O)Nc1ccc(C(=O)Nc2ccc(Nc3ncc4c(n3)N(C)c3ccc(C)cc3C(=O)N4C)cc2)cc1 CHEMBL4206831 IC50 82.0 nM
CS(=O)(=O)c1ccc(-c2cnc3[nH]nc(-c4cc(F)cc(NC(=O)Nc5cncnc5)c4)c3c2)cc1 CHEMBL5432215 IC50 82.0 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)c3ccc(C4CCN(c5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)cc3)CC2)n[nH]1 CHEMBL5434881 IC50 82.7 nM
CCc1ccccc1C(C(=O)Nc1ccc2[nH]nc(-c3cccc(S(N)(=O)=O)c3)c2c1)N(C)C CHEMBL3330409 IC50 83.0 nM
Cc1cc(Nc2nc(NCc3ccc(F)c(N4CCSCC4)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5396416 IC50 85.4 nM
NS(=O)(=O)c1cccc(-c2n[nH]c3ccc(NC(=O)C(c4ccsc4)N4CCCC4)cc23)c1 CHEMBL3330410 IC50 89.0 nM
COCCN(C)c1cc(CNc2nc(Nc3cc(C)[nH]n3)c3cnn(C4CCOCC4)c3n2)ccc1F CHEMBL5407310 IC50 90.7 nM
CS(=O)(=O)c1cccc(-c2cnc3[nH]nc(-c4cc(F)cc(NC(=O)Nc5cccnc5)c4)c3c2)c1 CHEMBL5431124 IC50 94.0 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 Kd 96.0 nM
CN1CCN(c2cccc(-c3cnc4[nH]nc(-c5cc(F)cc(NC(=O)Nc6cncnc6)c5)c4c3)c2)CC1 CHEMBL5394160 IC50 97.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN5CCCC5)cnc(N)c34)cc2)c1 CHEMBL1973211 pKi 100.0 nM
NC(=O)c1ccc(-c2c[nH]c3nccc(Cl)c23)cc1 CHEMBL1982711 pKi 100.0 nM
Nc1ncc(-c2ccoc2)c2scc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)c12 CHEMBL1965570 pKi 100.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CC(C)(C)N)cnc(N)c34)cc2)c1 CHEMBL1979577 pKi 100.0 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(F)c1 CHEMBL2003638 pKi 100.0 nM
CN1CCN(Cc2cc3cc(c2)Nc2nccc(n2)-c2cccc(c2)CNC(=O)[C@@H]2CCCN2C3)CC1 CHEMBL2407902 Ki 100.0 nM
CNC(=O)c1ccccc1Sc1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL5440186 IC50 102.0 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(Cc3ccc(C4CCN(c5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)cc3)CC2)n[nH]1 CHEMBL5394971 IC50 105.9 nM
Cc1nc2c(F)cc(-c3c[nH]c4ncc(-c5cccc(S(C)(=O)=O)c5)cc34)cc2n1C(C)C CHEMBL5435316 IC50 106.0 nM
CC(=O)Nc1cc(F)cc(-c2n[nH]c3ncc(-c4cccc(S(C)(=O)=O)c4)cc23)c1 CHEMBL5427137 IC50 106.0 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)cc3)nc3c2cnn3CC(F)(F)F)n[nH]1 CHEMBL5190474 IC50 117.9 nM
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=O)c1c(F)cccc1F CHEMBL191003 Kd 120.0 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)CCCCCCCCCCCCCCCOc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)n[nH]1 CHEMBL5431008 IC50 121.3 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4ccccc4Br)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5435416 IC50 121.9 nM
CC(C)Nc1cc(F)cc(-c2n[nH]c3ncc(-c4cccc(S(C)(=O)=O)c4)cc23)c1 CHEMBL5407680 IC50 123.0 nM
c1cc(Sc2ccc3[nH]ncc3c2)nc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL5410562 IC50 125.0 nM
COC(=O)c1c(-c2ccc(NC(=O)Nc3ccccc3)cc2)c2c(N)ncnn2c1C CHEMBL1977041 pKi 125.89 nM
CCOc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)cc1 CHEMBL1974254 pKi 125.89 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)cc1)CCN2 CHEMBL411903 pKi 125.89 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#Cc5cccnc5)cnc(N)c34)cc2)c1 CHEMBL1971947 pKi 125.89 nM
Cc1cccc(NC(=O)Nc2ccc(-c3coc4ncnc(N)c34)cc2)c1 CHEMBL1983963 pKi 125.89 nM
Cc1cccc(Nc2nc(NC3CCCCC3N)cnc2C(N)=O)c1 CHEMBL1974328 pKi 125.89 nM
Cc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1Nc1ccc(OCC(N)=O)cc1 CHEMBL1988838 pKi 125.89 nM
Nc1ncc(C=CC(=O)NCCCn2ccnc2)c2scc(-c3ccc(Br)cc3)c12 CHEMBL1994938 pKi 125.89 nM
CC(C)(C)NC(=O)c1ccc2nc3[nH]c4ccccc4c3nc2c1 CHEMBL1969264 pKi 125.89 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(/C=C/c3ccccc3)n2)n[nH]1 CHEMBL482968 Kd apparent 129.0 nM
CCc1cccc(CC)c1NC(=O)Nc1ccc2[nH]nc(-c3cccc(S(N)(=O)=O)c3)c2c1 CHEMBL3330260 IC50 130.0 nM
O=C(N[C@@H](c1ccccn1)C1CC1)c1ccc2[nH]nc(-c3ccc(N4[C@H]5CC[C@H]4CC(O)C5)cc3)c2c1 CHEMBL3422092 IC50 130.0 nM
Fc1ccccc1Sc1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL5416874 IC50 136.0 nM
Nc1ccc(Sc2ccnc(Nc3cccc(CN4CCOCC4)c3)n2)cc1 CHEMBL5409014 IC50 137.0 nM
Nc1ccc(Sc2ccnc(Nc3ccc(N4CCNCC4)cc3)n2)cc1 CHEMBL5407687 IC50 139.0 nM
COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1 CHEMBL1908396 Kd 140.0 nM
Clc1ccccc1Sc1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL5410643 IC50 142.0 nM
Clc1ccc(Sc2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL5414664 IC50 149.0 nM
Nc1cccc(Sc2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)c1 CHEMBL5405862 IC50 153.0 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)CCCCCCCCCCCCCOc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)n[nH]1 CHEMBL5396799 IC50 153.8 nM
CCn1c(C)c(-c2ccnc(Nc3cccc(OC)c3)n2)sc1=O CHEMBL1986263 pKi 158.49 nM
COc1ccc(C(=O)N2c3ccccc3Sc3c(Cl)cncc32)cc1 CHEMBL1988537 pKi 158.49 nM
Nc1n[nH]c2cc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)ccc12 CHEMBL1997623 pKi 158.49 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cnc4c(-c5cnn(C)c5)cnn4c3N)cc2)c1 CHEMBL508928 pKi 158.49 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN)cnc(N)c34)cc2)c1 CHEMBL1965988 pKi 158.49 nM
O=C1NN=Cc2c[nH]c3cc(NC(=O)C4CC4c4ccccc4)cc1c23 CHEMBL1969502 pKi 158.49 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)c1 CHEMBL196363 pKi 158.49 nM
CC(C)Cc1cc(-c2ccc3[nH]nc(N)c3c2)on1 CHEMBL1966343 pKi 158.49 nM
O=C1Nc2ccccc2Nc2nnc(I)cc21 CHEMBL1977346 pKi 158.49 nM
O=C1Cc2c([nH]c3ccc([N+](=O)[O-])cc23)-c2ccccc2N1 CHEMBL50894 pKi 158.49 nM
Cc1cncc2cccc(S(=O)(=O)N3CCCNCC3C)c12 CHEMBL1082440 pKi 158.49 nM
NCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL590109 pKi 158.49 nM
Cc1ccc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1988075 pKi 158.49 nM
COc1cc(C=C(C#N)c2nc3cc(C)ccc3[nH]2)c(Br)cc1O CHEMBL2000345 pKi 158.49 nM
COc1cccc(CNC(=O)c2cc3c(-c4ccccc4)n[nH]c3s2)c1 CHEMBL1987009 pKi 158.49 nM
c1ccc(CNc2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL5413952 IC50 176.0 nM
c1ccc2c(Sc3ccnc(Nc4ccc(N5CCOCC5)cc4)n3)cccc2c1 CHEMBL5420027 IC50 177.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 180.0 nM
O=C(O)C1(Cc2cccc(Nc3nccs3)n2)CCC(Oc2cccc(Cl)c2F)CC1 CHEMBL3182444 Kd apparent 183.0 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4ccc(Cl)cc4)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5408496 IC50 186.1 nM
Brc1ccc(Sc2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL5415514 IC50 189.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 190.0 nM
Fc1ccc(Sc2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL5402575 IC50 198.0 nM
Cc1cccc(NC(=O)Cc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL1964307 pKi 199.53 nM
CC(=O)N1CCN(C2CCC(n3nc(-c4ccc(NC(=O)c5cc6ccccc6n5C)cc4)c4c(N)ncnc43)CC2)CC1 CHEMBL1972584 pKi 199.53 nM
CN(C)c1cc2sncc2cc1NC(=O)C(=O)O CHEMBL1997023 pKi 199.53 nM
CC(C)(C)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1970104 pKi 199.53 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 pKi 199.53 nM
NC(=O)Cn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL1985095 pKi 199.53 nM
NC(=O)c1cc2c(-c3cccc(F)c3)cncc2s1 CHEMBL1971017 pKi 199.53 nM
O=C(NCC1CCCCC1)c1cc2c(-c3ccccc3)n[nH]c2s1 CHEMBL2005475 pKi 199.53 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 199.53 nM
Nc1ncc(-c2ccoc2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1966514 pKi 199.53 nM
COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(C(N)=O)s3)c2cc1OC CHEMBL514499 pKi 199.53 nM
N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL1789941 Kd 200.0 nM
Cc1cc(Nc2nc(Nc3ccccc3)nc3[nH]ncc23)n[nH]1 CHEMBL5192817 IC50 206.0 nM
CS(=O)(=O)c1cccc(-c2cnc3[nH]nc(-c4cc(F)cc(NC(=O)Nc5cccc(N)c5)c4)c3c2)c1 CHEMBL5411283 IC50 208.0 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4cccc(C#N)c4)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5420852 IC50 214.4 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)Cc3ccc(N4CCN(c5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)cc3)CC2)n[nH]1 CHEMBL5432601 IC50 215.6 nM
CS(=O)(=O)c1cccc(-c2cnc3[nH]nc(-c4cc(F)cc(NC(=O)Nc5ccnnc5)c4)c3c2)c1 CHEMBL5439579 IC50 217.0 nM
Brc1ccccc1Sc1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL5408339 IC50 219.0 nM
O=C1Nc2ccccc2C1=Cc1ccc2c(-c3ccncc3)n[nH]c2c1 CHEMBL4562664 IC50 220.0 nM
O=C1Nc2ccccc2/C1=C/c1ccc(O)cc1 CHEMBL313578 IC50 230.0 nM
O=C1Nc2ccc(I)cc2/C1=C/c1cc(Br)c(O)c(Br)c1 CHEMBL72365 IC50 230.0 nM
O=C1Nc2ccccc2/C1=C/c1ccc2cn[nH]c2c1 CHEMBL3353337 IC50 230.0 nM
O=C1Nc2ccc(F)cc2/C1=C/c1ccc2cn[nH]c2c1 CHEMBL2407913 IC50 240.0 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)cc3)nc3c2cnn3-c2ccc(F)cc2)n[nH]1 CHEMBL5181116 IC50 241.3 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4cccc(OC(F)(F)F)c4)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5429940 IC50 243.5 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL1972158 pKi 251.19 nM
CC(C)N(C)C(=O)c1c(-c2ccc3[nH]ncc3c2)nnn1Cc1ccccc1 CHEMBL1969561 pKi 251.19 nM
NC(=O)c1cccc(-c2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982957 pKi 251.19 nM
CCC(N)(C#Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12)CC CHEMBL1983025 pKi 251.19 nM
CS(=O)(=O)N(Cc1ccc2[nH]c(=O)c3cccn3c2c1)C1CC1 CHEMBL1978448 pKi 251.19 nM
CCN(CC)CC#Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL2001257 pKi 251.19 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL1967531 pKi 251.19 nM
COc1cc(N2CCN(C)CC2)ccc1C(=O)Nc1n[nH]c2ccc(Cc3cc(F)cc(F)c3)cc12 CHEMBL1973961 pKi 251.19 nM
OC1CCN(c2ncnc3[nH]cc(-c4ccccc4)c23)CC1 CHEMBL1973395 pKi 251.19 nM
Cc1cccc(NC(=O)Nc2ccc3c(c2)CCc2sc4ncnc(N)c4c2-3)c1 CHEMBL1242373 pKi 251.19 nM
NC(=O)c1c(OCc2c(F)cc(Br)cc2F)nsc1NC(=O)NCCCCN1CCCC1 CHEMBL253969 pKi 251.19 nM
CCCCOc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1996817 pKi 251.19 nM
CS(=O)(=O)c1cccc(-c2cnc3[nH]nc(-c4cc(F)cc(NC(=O)Nc5cccnn5)c4)c3c2)c1 CHEMBL5440224 IC50 253.0 nM
C[C@H]1C/C=C/[C@@H](O)[C@@H](O)CC/C=C/c2cc(O)cc(O)c2C(=O)O1 CHEMBL1173442 Kd 260.0 nM
CN1CCN(c2ccc(-c3cnc4[nH]nc(-c5cc(F)cc(NC(=O)Nc6cncnc6)c5)c4c3)cc2)CC1 CHEMBL5439625 IC50 277.0 nM
CCNc1cc(F)cc(-c2n[nH]c3ncc(-c4cccc(S(C)(=O)=O)c4)cc23)c1 CHEMBL5441117 IC50 289.0 nM
Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O CHEMBL477772 Kd 290.0 nM
Nc1ccccc1Sc1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL5431580 IC50 297.0 nM
CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1 CHEMBL460702 Kd apparent 301.0 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Cl)[nH]n1 CHEMBL1231124 Kd apparent 308.0 nM
CN(C)c1ccc(Sc2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL5438910 IC50 313.0 nM
Cc1cccc(-c2[nH]c(-c3ccnc(N)n3)cc2C(N)=O)c1C CHEMBL1964290 pKi 316.23 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL219722 pKi 316.23 nM
CCn1c(-c2nonc2N)nc2cnc(Oc3cccc(NC(=O)c4ccc(OCCN5CCOCC5)cc4)c3)cc21 CHEMBL220241 pKi 316.23 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(-c3c(C)sc4ncnc(N)c34)cc2)c1 CHEMBL371206 pKi 316.23 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4c3CNC4=O)cc2)c1 CHEMBL185569 pKi 316.23 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccc(F)cc3)cc12 CHEMBL1986499 pKi 316.23 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc32)c1C CHEMBL1990885 pKi 316.23 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cc(C(=O)O)ccc4F)cc3)c12 CHEMBL1993722 pKi 316.23 nM
Cn1cc(C2=C(c3cccc(NCC(O)CO)c3)C(=O)NC2=O)c2cc(F)ccc21 CHEMBL1082152 Kd 320.0 nM
CS(=O)(=O)c1cccc(-c2cnc3[nH]nc(-c4cc(F)cc(NC(=O)Nc5cccc(Cl)c5)c4)c3c2)c1 CHEMBL5410589 IC50 325.0 nM
CS(=O)(=O)c1cccc(-c2cnc3[nH]nc(-c4cc(F)cc(NC(=O)Nc5ccncc5)c4)c3c2)c1 CHEMBL5420676 IC50 328.0 nM
CCNC(=O)C#Cc1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN(C)C)cc1)c1ccccc1 CHEMBL3699142 Kd apparent 333.0 nM
CNc1cc(F)cc(-c2n[nH]c3ncc(-c4cccc(S(C)(=O)=O)c4)cc23)c1 CHEMBL5407899 IC50 335.0 nM
Cc1cc(Nc2cc(Cc3ccccc3)nc(NC3CCNCC3)n2)n[nH]1 CHEMBL5175418 IC50 351.5 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4ccc(Br)cc4)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5423111 IC50 352.7 nM
CC(=O)Nc1cc(Cl)cc(-c2n[nH]c3ncc(-c4cccc(S(C)(=O)=O)c4)cc23)c1 CHEMBL5409987 IC50 359.0 nM
CS(=O)(=O)c1cccc(-c2cnc3[nH]nc(-c4cc(F)cc(NC(=O)Nc5cccc(C(F)(F)F)c5)c4)c3c2)c1 CHEMBL5410573 IC50 365.0 nM
CN(C)C[C@@H]1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1 CHEMBL91829 Kd 370.0 nM
CC(C)(C)Nc1cc(F)cc(-c2n[nH]c3ncc(-c4cccc(S(C)(=O)=O)c4)cc23)c1 CHEMBL5410628 IC50 378.0 nM
Nc1ccc(Sc2ccnc(Nc3ccc(CN4CCNCC4)cc3)n2)cc1 CHEMBL5432922 IC50 379.0 nM
CS(=O)(=O)c1cccc(-c2cnc3[nH]nc(-c4cc(F)cc(NC(=O)Nc5cccc(F)c5)c4)c3c2)c1 CHEMBL5395499 IC50 387.0 nM
O=C1Nc2ccccc2/C1=C/c1ccc2[nH]ncc2c1 CHEMBL2407910 IC50 390.0 nM
COc1cccc(NC(=O)Nc2cc(F)cc(-c3n[nH]c4ncc(-c5cccc(S(C)(=O)=O)c5)cc34)c2)c1 CHEMBL5424061 IC50 396.0 nM
CCc1nc2c(c3cc(OC)c(OC)cc13)C(=O)NC2=O CHEMBL2003524 pKi 398.11 nM
NC(=O)c1cccc2c1Nc1nnc(Cl)cc1C(=O)N2 CHEMBL1968070 pKi 398.11 nM
Cc1ccc(NC(=O)Nc2ccc(-c3coc4ncnc(N)c34)cc2)cc1 CHEMBL2005828 pKi 398.11 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1336 pKi 398.11 nM
Nc1ncnc2c1sc1ncnc(N)c12 CHEMBL1976090 pKi 398.11 nM
COc1cc(-c2nn(C3CCC(N4CCN(C(C)=O)CC4)CC3)c3ncnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C CHEMBL1970879 pKi 398.11 nM
Cc1cc(C)c(C=C2C(=O)Nc3ccccc32)[nH]1 CHEMBL2002702 pKi 398.11 nM
O=C1Nc2ccccc2Nc2nnccc21 CHEMBL1971801 pKi 398.11 nM
COc1cc(Nc2nccc(Nc3cc(C4CCCCC4)no3)n2)cc(OC)c1OC CHEMBL1984711 pKi 398.11 nM
Cc1n[nH]c2ncc(C#N)c(-c3ccccc3)c12 CHEMBL1965495 pKi 398.11 nM
NC(=O)c1cc2c(-c3ccccc3)cncc2s1 CHEMBL1999556 pKi 398.11 nM
O=C(O)c1cc2c(-c3ccccc3)cncc2s1 CHEMBL1996390 pKi 398.11 nM
O=C1Cc2c([nH]c3ccc(Br)cc23)-c2ccccc2N1 CHEMBL296586 pKi 398.11 nM
O=C(O)c1ccc(Nc2ncc3c(n2)-c2ccc(Cl)cc2C(c2c(F)cccc2F)=NC3)cc1 CHEMBL259084 Kd 410.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 CHEMBL450786 Kd 410.0 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(NC4CCS(=O)(=O)CC4)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5399599 IC50 410.6 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4cc(F)c(F)c(F)c4)c3)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5400736 IC50 420.6 nM
CS(=O)(=O)c1cccc(-c2cnc3[nH]nc(-c4cc(N)cc(F)c4)c3c2)c1 CHEMBL5420664 IC50 421.0 nM
Cc1cc(Nc2nc(NC3CCNC3)nc3[nH]ncc23)n[nH]1 CHEMBL5176750 IC50 453.9 nM
Cc1cc(Nc2nc(NC3CCNCC3)nc3[nH]ncc23)n[nH]1 CHEMBL5186873 IC50 483.9 nM
Cc1cc(Nc2nc(Cl)nc3[nH]ncc23)n[nH]1 CHEMBL5173615 IC50 489.1 nM
O=C1Nc2ccccc2/C1=C\c1ccc2c(-c3nccs3)n[nH]c2c1 CHEMBL4466113 IC50 490.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)ccn1 CHEMBL1992306 pKi 501.19 nM
Cc1cc(NC(=O)Cc2ccc(-c3cccc4[nH]nc(N)c34)cc2)ccc1F CHEMBL1984363 pKi 501.19 nM
c1cc2cc(-c3ccc4cn[nH]c4c3)cnc2[nH]1 CHEMBL1976134 pKi 501.19 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1Cl CHEMBL1965660 pKi 501.19 nM
O=C1NCc2c1cccc2-c1ccc(Nc2nc3ccccc3o2)cc1 CHEMBL2004771 pKi 501.19 nM
Cc1c(-c2ccc3[nH]nc(N)c3c2)nnn1Cc1ccccc1 CHEMBL1989646 pKi 501.19 nM
c1ccc(CNc2cc(-c3c[nH]c4ncccc34)ncn2)cc1 CHEMBL2002346 pKi 501.19 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cc(CO)ccc4F)cc3)c12 CHEMBL1985311 pKi 501.19 nM
COc1ccc(-c2cnc3c(Br)cnn3c2)cc1 CHEMBL443962 pKi 501.19 nM
CN1CCN(c2ccc(-c3cnc4c(c3)N(Cc3c(F)ccc(F)c3Cl)CCN4)cn2)CC1 CHEMBL1164265 pKi 501.19 nM
COc1cc(C=C(C#N)c2nc3ccccc3[nH]2)c(Br)cc1O CHEMBL1994241 pKi 501.19 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL220057 pKi 501.19 nM
Cc1ccccc1NC(=O)Nc1ccc(-c2coc3ncnc(N)c23)cc1 CHEMBL1984586 pKi 501.19 nM
O=C(NN=Cc1ccc(O)cc1O)Nc1cccc2nsnc12 CHEMBL1999811 pKi 501.19 nM
c1cnc2[nH]cc(-c3ccnc(NC4CCCCC4)n3)c2c1 CHEMBL385478 pKi 501.19 nM
COc1ccc(-c2ccc(NC(=O)Nc3cccc(Br)c3)cc2)c2c(N)noc12 CHEMBL271381 pKi 501.19 nM
Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c12 CHEMBL1976220 pKi 501.19 nM
CS(=O)(=O)c1cccc(-c2cnc3[nH]nc(-c4cc(F)cc(NC(=O)Nc5ccc(Cl)cc5)c4)c3c2)c1 CHEMBL5404860 IC50 507.0 nM
COc1cc(NC(C)=O)cc(-c2n[nH]c3ncc(-c4cccc(S(C)(=O)=O)c4)cc23)c1 CHEMBL5433061 IC50 511.0 nM
Cc1cc(Nc2nc(NCc3ccc(Cl)c(C(=O)Nc4cc(F)ccc4F)c3)nc3c2cnn3C2CC(C)(C)OC(C)(C)C2)n[nH]1 CHEMBL5399648 IC50 511.2 nM
Nc1ccc(Sc2ccnc(Nc3ccccc3)n2)cc1 CHEMBL5412717 IC50 519.0 nM
CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1 CHEMBL2028663 Kd apparent 520.0 nM
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCN(C(=O)CCCCCCCCCCCOc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)n[nH]1 CHEMBL5401859 IC50 531.5 nM
Cc1cc(Nc2nc(N3CCNCC3)nc3[nH]ncc23)n[nH]1 CHEMBL5205336 IC50 533.0 nM
Fc1ccc(CNc2nc(Nc3n[nH]c4ccccc34)c3cnn(C4CCOCC4)c3n2)c(F)c1 CHEMBL5179755 IC50 535.8 nM
O=C1Nc2ccccc2C1=Cc1ccc2c(-c3cc4ccccc4[nH]3)n[nH]c2c1 CHEMBL4457259 IC50 540.0 nM
CS(=O)(=O)c1cccc(-c2cnc3[nH]nc(-c4cc(F)cc(NC(=O)Nc5ccc(F)cc5)c4)c3c2)c1 CHEMBL5440423 IC50 561.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)N(COP(=O)(O)O)C(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL2103830 Kd apparent 570.0 nM
CCn1cc(-c2ccnc3[nH]c(-c4cccc(CN(C)C)c4)cc23)c(-c2ccc(NC(=O)N(C)C)cc2)n1 CHEMBL1090479 Kd apparent 575.0 nM
CCOc1cc(N2CCC(O)CC2)ccc1Nc1ncc2c(n1)N(C)c1ccccc1C(=O)N2C CHEMBL1673046 Kd 600.0 nM
Cc1nc2c(F)cc(-c3n[nH]c4ccc(-c5cccc(S(C)(=O)=O)c5)nc34)cc2n1C(C)C CHEMBL5432853 IC50 614.0 nM
N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL1078178 Kd apparent 619.0 nM
COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 CHEMBL24828 Kd 620.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL223360 pKi 630.96 nM
O=C(NCc1ccc(Cl)cc1)c1cc2c(-c3ccccc3)n[nH]c2s1 CHEMBL1967094 pKi 630.96 nM
Nc1ncnc2sc3c(c12)-c1ccc(NC(=O)Nc2ccccc2)cc1CC3 CHEMBL1994693 pKi 630.96 nM
Nc1ncnc2c1c(I)nn2C1CCC(O)CC1 CHEMBL1996791 pKi 630.96 nM
CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL1084546 pKi 630.96 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(-c3cccc4c3CNC4=O)c(C)c2)c1 CHEMBL2004311 pKi 630.96 nM
N#CC(=Cc1ccc(O)c(O)c1)C(=O)NCc1ccccc1 CHEMBL1974157 pKi 630.96 nM
NC(COc1cncc(-c2cc3ccncc3s2)c1)Cc1c[nH]c2ccccc12 CHEMBL1966524 pKi 630.96 nM
Cc1nc(Nc2n[nH]c3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)c2sccc2n1 CHEMBL3128043 Kd apparent 668.0 nM
O=C(c1cccc(-c2n[nH]c3ncc(Cc4cc(F)ccc4F)cc23)c1)N1CCC[C@@H](O)C1 CHEMBL5276440 IC50 690.0 nM
O=C(NCCc1ccc(O)c(Br)c1)/C(Cc1cc(Br)c(O)c(Oc2ccc(CCNC(=O)/C(Cc3cc(Br)c(O)c(-c4cc(C/C(=N\O)C(=O)NCCc5ccc(O)c(Br)c5)cc(Br)c4O)c3)=N/O)cc2Br)c1)=N/O CHEMBL2333163 IC50 700.0 nM
CS(=O)(=O)c1cccc(-c2cnc3[nH]nc(-c4cc(F)cc(NC(=O)Nc5cccc(Br)c5)c4)c3c2)c1 CHEMBL5421379 IC50 719.0 nM
NC(=O)Nc1cc(-c2cccc(F)c2)sc1C(=O)N[C@H]1CCCNC1 CHEMBL2041933 Kd apparent 722.0 nM
CC(C)(C)c1cc(Nc2nc(NCc3ccc(F)cc3F)nc3c2cnn3C2CCOCC2)n[nH]1 CHEMBL5185066 IC50 725.6 nM
CC(=O)Nc1cc(C#N)cc(-c2n[nH]c3ncc(-c4cccc(S(C)(=O)=O)c4)cc23)c1 CHEMBL5438941 IC50 782.0 nM
Cc1ccc(-c2cc3c(NCCN)ccc(C(N)=O)c3[nH]2)cc1 CHEMBL1996048 pKi 794.33 nM
CC(=O)Nc1cccc(CNc2c(Nc3ccc4[nH]ncc4c3)c(=O)c2=O)c1 CHEMBL1988608 pKi 794.33 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1F CHEMBL1981079 pKi 794.33 nM
COc1cc2cnc3c(c2cc1OC)C(=O)NC3=O CHEMBL1982506 pKi 794.33 nM
CNC(=O)C=Cc1cnc(N)c2c(-c3ccc4c(c3)OCO4)csc12 CHEMBL1993243 pKi 794.33 nM
O=C(NNC(=S)Nc1ccc(Cl)cc1)C(O)(c1ccccc1)c1ccccc1 CHEMBL1966722 pKi 794.33 nM
O=C1NCCc2[nH]c(-c3ccncc3)cc21 CHEMBL225519 pKi 794.33 nM
CC(=NNC(=N)N)c1cc(NC(=O)c2cccc(C(=O)Nc3cc(C(C)=NNC(=N)N)cc(C(C)=NNC(=N)N)c3)c2)cc(C(C)=NNC(=N)N)c1 CHEMBL2000685 pKi 794.33 nM
Cc1c(C=O)c(O)n2c(nc3ccccc32)c1C#N CHEMBL1989856 pKi 794.33 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4ccccc4F)c3)cc21 CHEMBL226471 pKi 794.33 nM
NCCC(C(=O)Nc1ccc2[nH]ncc2c1)c1ccc(Cl)c(Cl)c1 CHEMBL1998121 pKi 794.33 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL1240703 Kd 850.0 nM
O=C1Nc2ccccc2/C1=C/c1cccc(O)c1 CHEMBL2407906 IC50 860.0 nM
COc1cc(/C=C2\C(=O)Nc3ccc(Br)cc32)cc(Cl)c1O CHEMBL2407903 IC50 860.0 nM
CS(=O)(=O)c1cccc(-c2cnc3[nH]nc(-c4cc(F)cc(NC(=O)Nc5ccccn5)c4)c3c2)c1 CHEMBL5415639 IC50 862.0 nM
O=C(Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1)C1CCCN1 CHEMBL3545328 Kd apparent 908.0 nM
Fc1ccc(CNc2nc(Nc3cc(-c4ccccc4)[nH]n3)c3cnn(C4CCOCC4)c3n2)c(F)c1 CHEMBL5192030 IC50 968.9 nM
COc1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)cc(OC)c1OC CHEMBL201511 IC50 990.0 nM
Cc1nc2ccc(NS(=O)(=O)c3ccc(N)cc3)cc2nc1C CHEMBL2006263 pKi 1000.0 nM
COc1ccc2c(c1)C(=Cc1c[nH]cn1)C(=O)N2 CHEMBL2002649 pKi 1000.0 nM
O=C1CCCN1Cc1ccc2c(c1)[nH]c(=O)c1cccn12 CHEMBL539474 pKi 1000.0 nM
COCCN(C)C(=O)c1c(-c2ccc3[nH]ncc3c2)nnn1Cc1ccccc1 CHEMBL1986970 pKi 1000.0 nM
O=C(O)c1cc2c(-c3cccc(F)c3)cncc2s1 CHEMBL1974457 pKi 1000.0 nM
NC(=O)c1cc2c(-c3ccc(Br)c(F)c3F)cncc2s1 CHEMBL1999918 pKi 1000.0 nM
NC(=O)c1sc2c(Br)ccc(Cl)c2c1N CHEMBL1998611 pKi 1000.0 nM
CNC(=O)C=Cc1cnc(N)c2c(-c3cc(F)c4[nH]c(C)cc4c3)csc12 CHEMBL2006778 pKi 1000.0 nM
Nc1ncnc2c1c(-c1cccc(OCc3ccccc3)c1)cn2C1CC(CN2CCCC2)C1 CHEMBL1988370 pKi 1000.0 nM
CS(=O)(=O)Nc1ccc(-c2ccc3[nH]nc(N)c3c2)cc1 CHEMBL2004892 pKi 1000.0 nM
Cc1ccc(-c2nn(C(C)(C)C)c3ncnc(N)c23)cc1 CHEMBL306380 pKi 1000.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4ccnc(N)c34)cc2)c1 CHEMBL394619 pKi 1000.0 nM
COc1ccc2c(NC(=O)Nc3cccc(C(F)(F)F)n3)ccnc2c1 CHEMBL1982660 pKi 1000.0 nM
COCc1nnn(-c2nonc2N)c1C(=O)NN=C(C)c1ccc(O)cc1O CHEMBL1991180 pKi 1000.0 nM
O=c1nc(-c2cc3c(Oc4ccc(I)cc4)cncc3s2)[nH]o1 CHEMBL497151 pKi 1000.0 nM
CN(C)C(=O)c1c(-c2ccc3[nH]ncc3c2)nnn1Cc1ccccc1 CHEMBL1996111 pKi 1000.0 nM
CSc1nn(-c2ccccn2)c(N)c1C(N)=O CHEMBL2004615 pKi 1000.0 nM
O=C1Nc2ccccc2[C@]12C[C@H]2c1ccc2cn[nH]c2c1 CHEMBL3353338 IC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM