Cc1nnc(C(=O)NCC#CCN(C(=O)Cc2ccc(C(F)(F)F)cc2C(F)(F)F)c2ccccc2)o1 CHEMBL5204203 IC50 0.068 nM
O=C(NCC#CCN(C(=O)Cc1ccc(C(F)(F)F)cc1C(F)(F)F)c1ccccc1)c1cccnc1 CHEMBL5175156 IC50 0.2 nM
O=C(NCC#CCN(C(=O)Cc1ccc(C(F)(F)F)cc1C(F)(F)F)c1ccccc1)c1ccccn1 CHEMBL5206022 IC50 0.4 nM
O=C(Cc1ccc(C(F)(F)F)cc1C(F)(F)F)N(CC#Cc1cccc(=O)[nH]1)c1ccccc1 CHEMBL5197367 IC50 0.51 nM
Nc1ccc(C#CCN(C(=O)Cc2ncc(C(F)(F)F)cc2C(F)(F)F)c2ccc(F)cc2)nn1 CHEMBL5187422 IC50 0.55 nM
O=C(Cc1ncc(C(F)(F)F)cc1C(F)(F)F)N(CC#Cc1ccc(C2CCNC2)cn1)c1ccc(F)cc1 CHEMBL5174509 IC50 0.72 nM
O=C(Cc1ncc(C(F)(F)F)cc1C(F)(F)F)N(CC#Cc1cnn(C2CNC2)c1)c1ccc(F)cc1 CHEMBL5197173 IC50 0.75 nM
CC(=O)NCC#CCN(C(=O)Cc1ccc(C(F)(F)F)cc1C(F)(F)F)c1ccccc1 CHEMBL5170373 IC50 0.82 nM
CS(=O)(=O)Cn1cc(C#CCN(C(=O)Cc2ncc(C(F)(F)F)cc2C(F)(F)F)c2ccc(F)cc2)cn1 CHEMBL5194637 IC50 0.91 nM
CC(C(N)=O)n1cc(C#CCN(C(=O)Cc2ncc(C(F)(F)F)cc2C(F)(F)F)c2ccc(F)cc2)cn1 CHEMBL5197021 IC50 0.99 nM
Cn1cncc1C#CCN(C(=O)Cc1ccc(C(F)(F)F)cc1C(F)(F)F)c1ccccc1 CHEMBL5187337 IC50 1.2 nM
O=C(Cc1ccc(C(F)(F)F)cc1C(F)(F)F)N(CC#Cc1cccnn1)c1ccccc1 CHEMBL5188048 IC50 1.4 nM
Nc1ncc(C#CCN(C(=O)Cc2ncc(C(F)(F)F)cc2C(F)(F)F)c2ccc(F)cc2)cn1 CHEMBL5181369 IC50 1.6 nM
Cn1nc(N)cc1C#CCN(C(=O)Cc1ncc(C(F)(F)F)cc1C(F)(F)F)c1ccc(F)cc1 CHEMBL5174376 IC50 1.7 nM
Cc1ccc(NC(=O)Nc2cncc(-c3ccc(OCC4(C)CCOC4)c(C)c3)n2)cn1 CHEMBL5429065 IC50 2.0 nM
COc1ncc(C#CCN(C(=O)Cc2ncc(C(F)(F)F)cc2C(F)(F)F)c2ccc(F)cc2)cn1 CHEMBL5200250 IC50 2.1 nM
O=C(Cc1ccc(C(F)(F)F)cc1C(F)(F)F)N(CC#Cc1cccnc1)c1ccccc1 CHEMBL5174283 IC50 2.5 nM
O=C(Cc1ccc(C(F)(F)F)cc1C(F)(F)F)N(CC#Cc1ccccn1)c1ccccc1 CHEMBL5195161 IC50 2.9 nM
O=C(Cc1ccc(C(F)(F)F)cc1C(F)(F)F)N(CC#Cc1ncccn1)c1ccccc1 CHEMBL5194194 IC50 3.9 nM
Cc1cc(C(F)(F)F)cc(N2C(=O)OC[C@H]2C(=O)N(C)c2ccc(F)c(C)c2F)n1 CHEMBL5208956 IC50 4.1 nM
Nc1cnc(C#CCN(C(=O)Cc2ncc(C(F)(F)F)cc2C(F)(F)F)c2ccc(F)cc2)cn1 CHEMBL5206029 IC50 4.2 nM
Cc1cccc(N(C)C(=O)[C@@H]2[C@H](O)CCN2c2nc(C)cc(C(F)(F)F)c2C#N)c1 CHEMBL5206992 Kd 4.8 nM
COc1ccc(C#CCN(C(=O)Cc2ncc(C(F)(F)F)cc2C(F)(F)F)c2ccc(F)cc2)nn1 CHEMBL5202450 IC50 4.9 nM
Cc1cc(C(F)(F)F)cc(N2C(=O)OC[C@H]2c2nc(Cl)cn2-c2ccc(F)c(Cl)c2)n1 CHEMBL5418074 IC50 5.0 nM
Cc1cc(C(F)(F)F)cc(N2C(=O)OC[C@H]2C(=O)N(C)c2ccc(F)c(Cl)c2F)n1 CHEMBL5205456 IC50 5.4 nM
Cc1cc(C(F)(F)F)cc(N2C(=O)C[C@@H](O)[C@H]2C(=O)N(C)c2ccc(F)c(Cl)c2)n1 CHEMBL5190089 IC50 5.9 nM
Cc1cccc(N(C)C(=O)[C@@H]2CCC(=O)N2c2cc(C(F)(F)F)cc(C)n2)c1 CHEMBL5175531 IC50 6.8 nM
Cc1cccc(N(C)C(=O)[C@@H]2COC(=O)N2c2cc(C(F)(F)F)cc(C)n2)c1 CHEMBL5176919 IC50 7.0 nM
Cc1cc(-c2nc(NC(=O)N[C@H]3CCCNC3)cs2)ccc1OC[C@]1(C)CCOC1 CHEMBL5411191 IC50 7.0 nM
CN(C(=S)Cn1nc2c(c1C(F)(F)F)CCC2)c1ccccc1 CHEMBL5195920 IC50 7.49 nM
Cc1cc(C(F)(F)F)cc(N2C(=O)[C@@H](O)[C@@H](O)[C@H]2C(=O)N(C)c2ccc(F)c(Cl)c2)n1 CHEMBL5191330 IC50 7.6 nM
Cc1cccc(N(C)C(=O)[C@@H]2C[C@H](O)CN2c2nc(C)cc(C(F)(F)F)c2C#N)c1 CHEMBL5206829 Kd 8.2 nM
Cc1cccc(N(C(=O)[C@@H]2CCCN2c2nc(C)cc(C(F)(F)F)c2C#N)C(C)C)c1 CHEMBL5180095 IC50 8.8 nM
Cn1cnc(C#CCN(C(=O)Cc2ncc(C(F)(F)F)cc2C(F)(F)F)c2ccc(F)cc2)c1 CHEMBL5200171 IC50 9.0 nM
Cc1cc(C(F)(F)F)cc(N2C(=O)OC[C@H]2C(=O)N(C)c2ccc(F)c(C)c2)n1 CHEMBL5200410 IC50 9.4 nM
CN(C(=O)Cc1ccc(C(F)(F)F)cc1C(F)(F)F)c1ccccc1 CHEMBL5203967 IC50 14.0 nM
C#CCN(C(=O)Cc1ccc(C(F)(F)F)cc1C(F)(F)F)c1ccccc1 CHEMBL5178605 IC50 14.0 nM
Cc1cc(C(F)(F)F)cc(N2C(=O)OC[C@H]2C(=O)N(C)c2cccc(Cl)c2)n1 CHEMBL5205799 IC50 15.0 nM
Cc1cc(C(F)(F)F)cc(N2C(=O)OC[C@H]2C(=O)N(C)c2ccc(F)c(Cl)c2)n1 CHEMBL5184660 IC50 15.0 nM
Cc1cc(C(F)(F)F)cc(N2C(=O)OC[C@H]2C(=O)N(C)c2cccc(Cl)c2F)n1 CHEMBL5191696 IC50 15.0 nM
Cc1cc(C(F)(F)F)c(C#N)c(N2C[C@@H](O)C[C@H]2C(=O)N(C)c2ccc(F)c(Cl)c2)n1 CHEMBL5411994 IC50 16.0 nM
CN(C(=O)Cc1ccc(C(F)(F)F)cc1C(F)(F)F)c1ccc(F)cc1 CHEMBL5185359 IC50 17.0 nM
[2H]C([2H])([2H])N(C(=O)Cc1ccc(C(F)(F)F)cc1C(F)(F)F)c1ccc(F)cc1 CHEMBL5181740 IC50 19.0 nM
Cc1cccc(N(C)C(=O)[C@@H]2C[C@H](O)CN2c2nc(C)cc(C)c2C#N)c1 CHEMBL5186881 Kd 19.0 nM
CCN(C(=O)[C@@H]1[C@H](O)[C@H](O)C(=O)N1c1cc(C(F)(F)F)cc(C)n1)c1ccc(F)c(Cl)c1 CHEMBL5171679 IC50 20.0 nM
Cc1cc(C(F)(F)F)cc(N2C(=O)OC[C@H]2C(=O)N(C)c2cc(Cl)ccc2F)n1 CHEMBL5174463 IC50 24.0 nM
Cc1cccc(N(C)C(=O)[C@@H]2[C@@H](O)CCN2c2nc(C)cc(C(F)(F)F)c2C#N)c1 CHEMBL5206124 Kd 24.0 nM
Cc1cc(C(F)(F)F)cc(N2C(=O)[C@@H](O)C[C@H]2C(=O)N(C)c2ccc(F)c(Cl)c2)n1 CHEMBL5205767 IC50 25.0 nM
CCN(C(=O)[C@@H]1C[C@H](O)CN1c1nc(C)cc(C(F)(F)F)c1C#N)c1cccc(C)c1 CHEMBL5192847 IC50 27.0 nM
CCN(C(=O)[C@H](C)Nc1nc(C)cc(C(F)(F)F)c1C#N)c1cccc(C)c1 CHEMBL5173746 IC50 29.0 nM
Cc1cc(C(F)(F)F)cc(N2C(=O)OC[C@H]2C(=O)N(C)c2cc(Cl)c(F)cc2F)n1 CHEMBL5205617 IC50 32.0 nM
Cc1cc(C(F)(F)F)cc(N2C(=O)OC[C@H]2C(=O)N(c2ccc(F)c(Cl)c2)C(C)C)n1 CHEMBL5195012 IC50 35.0 nM
CCN(C(=O)[C@H](CO)Nc1nc(C)cc(C(F)(F)F)c1C#N)c1cccc(C)c1 CHEMBL5174548 Kd 35.0 nM
CN(C(=O)Cc1ccc(C2CC2)cc1C(F)(F)F)c1ccccc1 CHEMBL5178606 IC50 40.0 nM
N#CCN(C(=O)Cc1ccc(C(F)(F)F)cc1C(F)(F)F)c1ccccc1 CHEMBL5206197 IC50 42.0 nM
CCN(C(=O)[C@H](C)Nc1nc(C)cc(C(C)C)c1C#N)c1cccc(C)c1 CHEMBL5186256 IC50 49.0 nM
CCN(C(=O)[C@@H]1COC(=O)N1c1cc(C(F)(F)F)cc(C)n1)c1ccc(F)c(Cl)c1 CHEMBL5186606 IC50 54.0 nM
CN(C(=O)Cn1c(C(F)(F)F)cc(C(F)(F)F)cc1=O)c1ccccc1 CHEMBL5208584 IC50 58.0 nM
CCN(C(=O)COc1nc(C)cc(C(F)(F)F)c1C#N)c1cccc(C)c1 CHEMBL5182311 Kd 61.0 nM
CN(C(=O)Cc1ncc(C(F)(F)F)cc1C(F)(F)F)c1ccccc1 CHEMBL5181730 IC50 65.0 nM
Cc1cccc(N(C)C(=O)[C@@H]2C[C@@H](O)CN2c2nc(C)cc(C(F)(F)F)c2C#N)c1 CHEMBL5170837 Kd 69.0 nM
CCN(C(=O)[C@@H]1CCCN1c1nc(C)cc(C)c1C#N)c1cccc(C)c1 CHEMBL5182333 IC50 72.0 nM
CCN(C(=O)[C@@H]1C[C@H](O)C(=O)N1c1cc(C(F)(F)F)cc(C)n1)c1ccc(F)c(Cl)c1 CHEMBL5208232 IC50 95.0 nM
Cc1cc(C(F)(F)F)c(C#N)c(N2C[C@@H](O)C[C@H]2C(=O)N(C)c2ccccc2)n1 CHEMBL5197468 Kd 110.0 nM
CN(C(=O)Cc1ccc(Cl)cc1C(F)(F)F)c1ccccc1 CHEMBL5200543 IC50 121.0 nM
CN(C(=O)Cn1nc2c(c1C(F)(F)F)CCCC2)c1ccccc1 CHEMBL5185248 IC50 170.0 nM
Cc1nc(SCC(=O)N(C)c2ccccc2)c(C#N)c(C)c1Cl CHEMBL5408410 IC50 200.0 nM
COc1cccc(F)c1-c1cc(C)ncc1C(=O)Nc1nnc(OCC(C)(C)C(F)(F)F)s1 CHEMBL5397469 IC50 200.0 nM
COc1cnc(Cl)cc1-c1cc(C)ncc1C(=O)Nc1nnc(O)s1 CHEMBL5394545 IC50 200.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2c(Cl)cccc2OC)s1 CHEMBL5438563 IC50 200.0 nM
CCOc1cnc(Cl)cc1-c1cc(C)ncc1C(=O)Nc1nnc(OC)s1 CHEMBL5394301 IC50 200.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc(C)nnc2OC)s1 CHEMBL5396010 IC50 200.0 nM
CCOc1ccc(Cl)cc1-c1cc(C)ncc1C(=O)Nc1nnc(OC)s1 CHEMBL5400391 IC50 200.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2c(Cl)cccc2OC(F)F)s1 CHEMBL5400345 IC50 200.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc(C)ncc2C)s1 CHEMBL5410876 IC50 200.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc(Cl)ccc2CO)s1 CHEMBL5413735 IC50 200.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2c(OC)cnc(Cl)c2C)s1 CHEMBL5432657 IC50 200.0 nM
COc1cnc(Cl)cc1-c1cc(C)ncc1C(=O)Nc1nnc(O[C@H]2CCO[C@H]2C)s1 CHEMBL5417737 IC50 200.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccnc(Cl)c2)s1 CHEMBL5402472 IC50 200.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(Cl)c2)s1 CHEMBL5425505 IC50 200.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc3cn[nH]c3cc2OC)s1 CHEMBL5431068 IC50 200.0 nM
COc1cnc(Cl)cc1-c1cc(C)ncc1C(=O)Nc1nnc(O[C@H]2CC[C@H]2O)s1 CHEMBL5402381 IC50 200.0 nM
COc1cnc(Cl)cc1-c1cc(C)ncc1C(=O)Nc1nnc(O[C@]2(C)CCOC2)s1 CHEMBL5415717 IC50 200.0 nM
COc1nnc(NC(=O)c2cnc(C3CCCC3)cc2-c2cc(Cl)ncc2OC)s1 CHEMBL5431120 IC50 200.0 nM
COc1cnc(Cl)cc1-c1cc(C)ncc1C(=O)Nc1nnc(O[C@H]2CCC[C@@](C)(O)C2)s1 CHEMBL5429664 IC50 200.0 nM
COc1cnc(Cl)cc1-c1cc(C)ncc1C(=O)Nc1nnc(O[C@@H]2CCC[C@](C)(O)C2)s1 CHEMBL5426123 IC50 200.0 nM
CCc1cc(C(=O)Nc2nnc(OC)s2)c(-c2cc(Cl)ncc2OC)cn1 CHEMBL5410935 IC50 200.0 nM
COc1nnc(NC(=O)c2cc(OC(C)C)ncc2-c2cc(Cl)ncc2OC)s1 CHEMBL5398575 IC50 200.0 nM
COc1cnc(Cl)cc1-c1cc(C)ncc1C(=O)Nc1nnc(OC2CCN(CC(F)(F)F)CC2)s1 CHEMBL5414247 IC50 200.0 nM
COc1cnc(Cl)cc1-c1cc(C)ncc1C(=O)Nc1nnc(O[C@@H]2C[C@H](F)CN(C(C)C)C2)s1 CHEMBL5426537 IC50 200.0 nM
COc1nnc(NC(=O)c2cc(C#N)ncc2-c2cc(Cl)ncc2OC)s1 CHEMBL5406609 IC50 200.0 nM
COc1nnc(NC(=O)c2nnc(C)cc2-c2cc(Cl)ncc2OC)s1 CHEMBL5407477 IC50 200.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc(C)c([S@+](C)[O-])cc2OC)s1 CHEMBL5424214 IC50 200.0 nM
CC[S@+]([O-])c1cc(OC)c(-c2cc(C)ncc2C(=O)Nc2nnc(OC)s2)cc1Cl CHEMBL5416059 IC50 200.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc3ccoc23)s1 CHEMBL5410999 IC50 200.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc3cnccc23)s1 CHEMBL5433294 IC50 200.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc(C)cc(F)c2)s1 CHEMBL5408368 IC50 200.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc3sccc23)s1 CHEMBL5441080 IC50 200.0 nM
COc1ccc(-c2cc(C)ncc2C(=O)Nc2nnc(OC)s2)c(OC)n1 CHEMBL5394648 IC50 200.0 nM
COc1ccc(-c2cc(C)ncc2C(=O)Nc2nnc(OC)s2)c(OC)c1 CHEMBL5425611 IC50 200.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc(C)nc(C)c2)s1 CHEMBL5433124 IC50 200.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc3ncccc23)s1 CHEMBL5430248 IC50 200.0 nM
CCN(C(=O)[C@H](C)Nc1nc(C)cc(C)c1C#N)c1cccc(C)c1 CHEMBL5170980 IC50 230.0 nM
CC1CCc2nn(CC(=O)N(C)c3ccccc3)c(C(F)(F)F)c21 CHEMBL5175626 IC50 240.0 nM
CCN(C(=O)COc1cc(C(C)C)cc(C)n1)c1cccc(C)c1 CHEMBL5186419 IC50 400.0 nM
CCN(C(=O)COc1nc(C)c(Br)c(C(F)(F)F)c1C#N)c1cccc(C)c1 CHEMBL5188870 IC50 400.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2c(Cl)cccc2Cl)s1 CHEMBL5439865 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccccc2OC)s1 CHEMBL5439673 IC50 500.0 nM
COc1nnc(NC(=O)c2c[n+]([O-])c(C)cc2-c2cc(Cl)ncc2OC)s1 CHEMBL5396063 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc(Cl)ncc2CO)s1 CHEMBL5430010 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc(N)ncc2OC)s1 CHEMBL5409216 IC50 500.0 nM
COCCOc1nnc(NC(=O)c2ccncc2-c2ccccc2OC)s1 CHEMBL5431723 IC50 500.0 nM
COc1cnc(Cl)cc1-c1cc(C2CCCC2)ncc1C(=O)Nc1nnc(O[C@@H]2CCOC2)s1 CHEMBL5426367 IC50 500.0 nM
COc1cnc(Cl)cc1-c1cc(OC2CC2)ncc1C(=O)Nc1nnc(O[C@@H]2CCOC2)s1 CHEMBL5440132 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(OC3CC3)cc2-c2cc(Cl)ncc2OC)s1 CHEMBL5424152 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc(Cl)c([S@@+](C)[O-])cc2OC)s1 CHEMBL5409355 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc(Br)c([S@+](C)[O-])cc2OC)s1 CHEMBL5416672 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc3[nH]ncc23)s1 CHEMBL5393900 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc(F)cc(F)c2)s1 CHEMBL5415171 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc3nccnc3c2)s1 CHEMBL5420036 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc(C)cc(C)c2)s1 CHEMBL5417176 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(C)c2)s1 CHEMBL5417811 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc3ccccc3c2)s1 CHEMBL5434681 IC50 500.0 nM
CCc1cccc(-c2cc(C)ncc2C(=O)Nc2nnc(OC)s2)c1 CHEMBL5400592 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(C)cc2C)s1 CHEMBL5399535 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccccc2C)s1 CHEMBL5441092 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(S(C)(=O)=O)c2)s1 CHEMBL5406800 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(OC(F)(F)F)c2)s1 CHEMBL5427867 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc3c(c2)OCO3)s1 CHEMBL5403968 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(F)c2)s1 CHEMBL5429302 IC50 500.0 nM
COc1cc(C)cc(-c2cc(C)ncc2C(=O)Nc2nnc(OC)s2)c1 CHEMBL5398328 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2csc3cnccc23)s1 CHEMBL5407471 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(F)cc2C)s1 CHEMBL5408032 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(F)c2C#N)s1 CHEMBL5405617 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc(F)cnc2OC)s1 CHEMBL5434925 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc(F)cc(C#N)c2)s1 CHEMBL5422287 IC50 500.0 nM
COc1ccc(F)c(-c2cc(C)ncc2C(=O)Nc2nnc(OC)s2)c1 CHEMBL5417172 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc3c(cnn3C)c2)s1 CHEMBL5430157 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccnc(C(F)(F)F)c2)s1 CHEMBL5427915 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(F)c(F)c2C)s1 CHEMBL5423869 IC50 500.0 nM
COc1ccc(OC)c(-c2cc(C)ncc2C(=O)Nc2nnc(OC)s2)c1 CHEMBL5438337 IC50 500.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc3[nH]ncc3c2)s1 CHEMBL5429722 IC50 500.0 nM
CN(C(=O)Cn1nc2c(c1C(F)(F)F)C(C)(C)CC2)c1ccccc1 CHEMBL5199017 IC50 520.0 nM
Cc1cccc(N(C)C(=O)[C@@H]2C[C@H](O)CN2c2nccc(C(F)(F)F)c2C#N)c1 CHEMBL5169944 Kd 520.0 nM
CCN(C(=O)COc1cc(C(F)(F)F)cc(C)n1)c1cccc(C)c1 CHEMBL5180697 IC50 530.0 nM
CN(C(=O)Cn1nc2c(c1C(F)(F)F)CC(C)(C)C2)c1ccccc1 CHEMBL5170248 IC50 560.0 nM
CCN(C(=O)COc1nc(C)c(Cl)c(C)c1C#N)c1cccc(C)c1 CHEMBL5173309 IC50 630.0 nM
CN(C(=O)Cn1nc2c(c1C(F)(F)F)CCC2)c1ccccc1 CHEMBL5190448 IC50 710.0 nM
CCN(C(=O)COc1nc(C)cc(C)c1C#N)c1cccc(C)c1 CHEMBL5172405 Kd 820.0 nM
CC1Cc2nn(CC(=O)N(C)c3ccccc3)c(C(F)(F)F)c2C1 CHEMBL5188740 IC50 950.0 nM
COc1cccc(F)c1-c1cc(C)ncc1C(=O)Nc1nnc(O)s1 CHEMBL5402313 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2c(C)n[nH]c2C)s1 CHEMBL5441022 IC50 1000.0 nM
COc1nnc(NC(=O)c2cn3ccnc3cc2-c2c(F)cccc2OC)s1 CHEMBL5417295 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc3[nH]ncc3cc2OC)s1 CHEMBL5416038 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc([C@@H](C)O)ncc2OC)s1 CHEMBL5422123 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc([C@H](C)O)ncc2OC)s1 CHEMBL5427836 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc3[nH]cnc3cc2OC)s1 CHEMBL5429953 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccn3nnnc23)s1 CHEMBL5407781 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccnc3nccn23)s1 CHEMBL5404593 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccnc3ncnn23)s1 CHEMBL5425775 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccncc2OC)s1 CHEMBL5428547 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc3nscc3c2)s1 CHEMBL5427588 IC50 1000.0 nM
COc1nnc(NC(=O)c2c[nH]nc2-c2cc(Cl)ncc2OC)s1 CHEMBL5410470 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cnn3c2OCC3)s1 CHEMBL5401418 IC50 1000.0 nM
COc1nnc(NC(=O)c2cc(-c3cc(Cl)ncc3OC)ncc2C)s1 CHEMBL5439503 IC50 1000.0 nM
COc1nnc(NC(=O)c2ccnc(C#N)c2-c2cc(Cl)ncc2OC)s1 CHEMBL5412459 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(P(C)(C)=O)cc2OC)s1 CHEMBL5409551 IC50 1000.0 nM
COc1cnc(Cl)cc1-c1cc(C)ncc1C(=O)Nc1nnc(O[C@H]2CN3CCC2CC3)s1 CHEMBL5436948 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc(C)c([S@@+](C)[O-])cc2OC)s1 CHEMBL5425954 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc(Cl)c([S@+]([O-])C3CC3)cc2OC)s1 CHEMBL5410292 IC50 1000.0 nM
COc1cnc(C)cc1-c1cc(C)ncc1C(=O)Nc1nnc(O)s1 CHEMBL5410631 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(C(=O)O)c2)s1 CHEMBL5402095 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc(C#N)cc(OC(F)(F)F)c2)s1 CHEMBL5412068 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccccc2)s1 CHEMBL5411057 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(F)c(OC)c2)s1 CHEMBL5435458 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccnc2)s1 CHEMBL5415564 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc3c(c2)C(=O)NC3)s1 CHEMBL5424699 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)s1 CHEMBL5397860 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cncc(C#N)c2)s1 CHEMBL5395464 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(C(=O)N(C)C)c2)s1 CHEMBL5401170 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc3cn[nH]c3c2)s1 CHEMBL5413798 IC50 1000.0 nM
CNC(=O)c1cncc(-c2cc(C)ncc2C(=O)Nc2nnc(OC)s2)c1 CHEMBL5424248 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cncc(C(N)=O)c2)s1 CHEMBL5416398 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cnc(C(F)(F)F)c(F)c2)s1 CHEMBL5438847 IC50 1000.0 nM
CNC(=O)c1cccc(-c2cc(C)ncc2C(=O)Nc2nnc(OC)s2)c1 CHEMBL5396995 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(C(=O)NC3CC3)c2)s1 CHEMBL5433536 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(OC)c(C#N)c2)s1 CHEMBL5428385 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc3c(c2)NC(=O)CO3)s1 CHEMBL5427033 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc3c(c2)CC(=O)N3)s1 CHEMBL5433836 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc3c(c2)OC(F)(F)O3)s1 CHEMBL5413469 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc(C3CC3)nn2C2CCCCO2)s1 CHEMBL5424686 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccn(C)c(=O)c2)s1 CHEMBL5409580 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc3[nH]ccc3c2)s1 CHEMBL5394247 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(C(N)=O)cc2)s1 CHEMBL5394994 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(F)c(F)c2)s1 CHEMBL5420434 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(C(F)(F)F)cc2)s1 CHEMBL5405366 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(C(C)(C)C)cc2)s1 CHEMBL5409740 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cnc3[nH]ncc3c2)s1 CHEMBL5427176 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccs2)s1 CHEMBL5400620 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cnc(N)c(C#N)c2)s1 CHEMBL5419642 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc[nH]c(=O)c2)s1 CHEMBL5415844 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(C#N)cc2)s1 CHEMBL5421045 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(C(=O)O)cc2)s1 CHEMBL5440377 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(F)cc2)s1 CHEMBL5437029 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(C(=O)N(C)C)cc2)s1 CHEMBL5416677 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(-c3ccccc3)cc2)s1 CHEMBL5400239 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(S(C)(=O)=O)cc2)s1 CHEMBL5419941 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(OC(F)(F)F)cc2)s1 CHEMBL5429696 IC50 1000.0 nM
COc1ccc(-c2cc(C)ncc2C(=O)Nc2nnc(OC)s2)cc1 CHEMBL5425603 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(S(N)(=O)=O)cc2)s1 CHEMBL5426929 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc3c(c2)CNC3=O)s1 CHEMBL5398493 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc3c(c2)CCO3)s1 CHEMBL5422513 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(C)c(C)c2)s1 CHEMBL5408948 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(S(=O)(=O)N(C)C)cc2)s1 CHEMBL5421638 IC50 1000.0 nM
CNS(=O)(=O)c1ccc(-c2cc(C)ncc2C(=O)Nc2nnc(OC)s2)cc1 CHEMBL5420822 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(S(N)(=O)=O)c2)s1 CHEMBL5413577 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(NS(C)(=O)=O)cc2)s1 CHEMBL5406567 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccsc2)s1 CHEMBL5395246 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccoc2)s1 CHEMBL5400281 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccco2)s1 CHEMBL5434953 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccccc2C(C)C)s1 CHEMBL5424605 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cnc3ccccc3c2)s1 CHEMBL5406601 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cnn3c2CCCC3)s1 CHEMBL5416281 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(S(=O)(=O)N(C)C)c2)s1 CHEMBL5438951 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cnc3[nH]ccc3c2)s1 CHEMBL5395123 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(NS(C)(=O)=O)c2)s1 CHEMBL5395382 IC50 1000.0 nM
CNS(=O)(=O)c1cccc(-c2cc(C)ncc2C(=O)Nc2nnc(OC)s2)c1 CHEMBL5425416 IC50 1000.0 nM
CNC(=O)c1ccc(-c2cc(C)ncc2C(=O)Nc2nnc(OC)s2)cc1 CHEMBL5414428 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cncc(C(=O)NC3CC3)c2)s1 CHEMBL5429364 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccnc(C)c2)s1 CHEMBL5440246 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccncc2C)s1 CHEMBL5429104 IC50 1000.0 nM
COc1ccc(-c2cc(C)ncc2C(=O)Nc2nnc(OC)s2)cn1 CHEMBL5426359 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(CN(C)C)c2)s1 CHEMBL5431949 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(OC)c2C#N)s1 CHEMBL5405722 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(N(C)C)c2)s1 CHEMBL5421741 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cnc(C#N)cc2C)s1 CHEMBL5434527 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(N3CCOCC3)c2)s1 CHEMBL5411126 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc3c(c2)COC3=O)s1 CHEMBL5440233 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc3cn(C)nc3c2)s1 CHEMBL5399739 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc3c(c2)OCCN3C)s1 CHEMBL5405363 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(OC)c(F)c2)s1 CHEMBL5411072 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cc(C)nn2C)s1 CHEMBL5423081 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cnc(C(F)(F)F)cc2C)s1 CHEMBL5402602 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cnc(N3CCOCC3)nc2)s1 CHEMBL5395919 IC50 1000.0 nM
COCCOc1cccc(-c2cc(C)ncc2C(=O)Nc2nnc(OC)s2)c1 CHEMBL5436176 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc3c(c2)CCN(C)C3)s1 CHEMBL5400762 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(C#N)nc2C)s1 CHEMBL5423640 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2coc3ccccc23)s1 CHEMBL5415572 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(C#N)nc2)s1 CHEMBL5399898 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc3occc(=O)c3c2)s1 CHEMBL5440804 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cnnc(C)c2)s1 CHEMBL5426645 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cscc2C#N)s1 CHEMBL5415976 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cnc(C#N)nc2)s1 CHEMBL5439197 IC50 1000.0 nM
COc1ccc(-c2cc(C)ncc2C(=O)Nc2nnc(OC)s2)c(F)c1 CHEMBL5408140 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(OC)c2F)s1 CHEMBL5437129 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(OC(F)F)cc2)s1 CHEMBL5404414 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cn[nH]c2)s1 CHEMBL5420968 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(O)c2)s1 CHEMBL5418839 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(-c3ccn(C)n3)c2)s1 CHEMBL5406843 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccccc2C#N)s1 CHEMBL5409334 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(S(C)(=O)=O)nc2)s1 CHEMBL5417510 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cnn(-c3ccccc3)c2C)s1 CHEMBL5411133 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(C)nc2)s1 CHEMBL5431550 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cnc(N(C)C)nc2)s1 CHEMBL5412919 IC50 1000.0 nM
CCc1ccc(-c2cc(C)ncc2C(=O)Nc2nnc(OC)s2)cc1 CHEMBL5428125 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cnn(-c3ccccc3)c2)s1 CHEMBL5434701 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccnc2C)s1 CHEMBL5418518 IC50 1000.0 nM
COc1cc(C)c(-c2cc(C)ncc2C(=O)Nc2nnc(OC)s2)cn1 CHEMBL5422620 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cn(C)c3ccccc23)s1 CHEMBL5424254 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(C(=O)O)c(F)c2)s1 CHEMBL5416042 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(OCC#N)c2)s1 CHEMBL5425698 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cnn(Cc3ccccc3)c2)s1 CHEMBL5436768 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc3ncncc3c2)s1 CHEMBL5395198 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cncc(F)c2)s1 CHEMBL5431501 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(CC(N)=O)c2)s1 CHEMBL5417813 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(CN(C)C)nc2)s1 CHEMBL5432765 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc(N3CCCCC3)cc2)s1 CHEMBL5419598 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(CC#N)c2)s1 CHEMBL5432007 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(N3CCCCC3)c2)s1 CHEMBL5423669 IC50 1000.0 nM
CNC(=O)c1ccc(-c2cc(C)ncc2C(=O)Nc2nnc(OC)s2)cn1 CHEMBL5399878 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc3ccn(C)c3c2)s1 CHEMBL5402774 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cnccc2C(F)(F)F)s1 CHEMBL5394356 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc3c2ccn3C)s1 CHEMBL5398105 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cncc(C(=O)N(C)C)c2)s1 CHEMBL5412778 IC50 1000.0 nM
CCCCc1ccc(-c2cc(C)ncc2C(=O)Nc2nnc(OC)s2)cc1 CHEMBL5420263 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc(C(N)=O)c2)s1 CHEMBL5400918 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2cccc3nn(C)cc23)s1 CHEMBL5435319 IC50 1000.0 nM
COc1nnc(NC(=O)c2cnc(C)cc2-c2ccc3nc[nH]c3c2)s1 CHEMBL5440899 IC50 1000.0 nM