COC(=O)C(CN1CCC(c2cc(-c3ccc(F)cc3)nn2-c2ncccn2)CC1)c1ccccc1 CHEMBL3910523 IC50 0.035 nM
Clc1ccc(-c2cc(C3CCN(CCc4ccccc4)CC3)n(-c3ncccn3)n2)cc1 CHEMBL3919329 IC50 0.051 nM
O=C(NC(c1ccc(Cl)cc1)c1ccnc(F)c1)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1 CHEMBL3086040 IC50 0.079 nM
C[C@H](NC(=O)[C@@H](NC(=O)C(C)(C)N)[C@@H](C)c1ccc(OCC(F)(F)F)cc1)c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1950440 IC50 0.17 nM
O=C(NC(c1ccncc1)c1ccc(Cl)cc1)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1 CHEMBL3086037 IC50 0.18 nM
O=C(NC(c1ccc(F)cc1)c1ccnc(F)c1)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1 CHEMBL3652599 IC50 0.18 nM
Cc1cc(C2CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(C)c(Cl)c2)n1 CHEMBL2022787 IC50 0.2 nM
Cc1cc(C2CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(Cl)c(Cl)c2)n1 CHEMBL2022793 IC50 0.2 nM
CC(C)(C)N1C[C@@H](C(=O)N2CCC(c3ccnn3-c3ccc(F)c(Cl)c3)CC2)[C@H](c2ccc(F)cc2F)C1 CHEMBL2023210 IC50 0.2 nM
O=C(CCN1CCC(c2ccccc2)CC1)NC(c1ccncc1)c1ccc(Cl)cc1 CHEMBL1938522 IC50 0.3 nM
Cc1cc(C2CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2cc(Cl)ccc2Cl)n1 CHEMBL2023202 IC50 0.3 nM
OC(CN1CCC(c2cc(-c3ccc(Cl)cc3)nn2-c2ncccn2)CC1)c1ccccc1 CHEMBL3901469 IC50 0.31 nM
C[C@H](NC(=O)[C@@H](NC(=O)C(C)(C)N)[C@@H](C)c1ccc(-c2ccccc2)cc1)c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1950444 IC50 0.37 nM
Cc1cc(C2CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(Cl)cc2Cl)n1 CHEMBL2022794 IC50 0.4 nM
CN(C)[C@]1(C)C[C@H](C(=O)N2CCC(c3ccnn3-c3ccc(F)c(Cl)c3)CC2)[C@@H](c2ccc(F)cc2F)C1 CHEMBL2031595 IC50 0.4 nM
FC(F)(F)Oc1ccc(CN2CCC3(CC2)OC(c2cc(Cl)ccn2)c2ccccc23)cc1 CHEMBL1951465 IC50 0.44 nM
CC(C)(c1ccc(OC(F)(F)F)cc1)N1CCC2(CC1)OC(c1cc(Cl)ccn1)c1cccnc12 CHEMBL1951476 IC50 0.49 nM
Cc1cc(C2CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(Cl)cc2F)n1 CHEMBL2023207 IC50 0.5 nM
Cc1cc(C2CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(F)c(Cl)c2)n1 CHEMBL2023209 IC50 0.5 nM
O=C(O)C(CN1CCC(c2cc(-c3ccc(F)cc3)nn2-c2ncccn2)CC1)c1ccccc1 CHEMBL3932961 IC50 0.51 nM
C[C@@H](c1ccc(-c2ccccc2)cc1)[C@H](NC(=O)C(C)(C)N)C(=O)NC(c1ccncc1)c1ccc(Cl)cc1 CHEMBL1938510 IC50 0.6 nM
O=C(NC(c1ccncc1)c1ccc(F)cc1)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1 CHEMBL3085780 IC50 0.6 nM
O=C(NC(c1ccc(F)cc1)c1ccc(F)cc1)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1 CHEMBL3086036 IC50 0.66 nM
Cc1cc(C2CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(Cl)cc2C)n1 CHEMBL2022786 IC50 0.7 nM
Clc1ccc(-c2nc(-c3ncccn3)c(C3CCN(CCc4ccccc4)CC3)[nH]2)cc1 CHEMBL3677679 IC50 0.7 nM
CC(c1ccc(F)cn1)N1CCC2(CC1)OC(c1cc(Cl)cc(Cl)c1)c1ccccc12 CHEMBL1951474 IC50 0.73 nM
C[C@H](NC(=O)[C@@H](NC(=O)C(C)(C)O)[C@@H](C)c1ccc(OCC(F)(F)F)cc1)c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1950439 IC50 0.74 nM
O=S(=O)(c1ccc(C(F)(F)F)cn1)N1CCC2(CC1)OC(c1cc(Cl)cc[n+]1[O-])c1ccccc12 CHEMBL1951478 IC50 0.78 nM
Fc1ccc(-c2nc(-c3ncccn3)c(C3CCN(CCc4ccccc4)CC3)o2)cc1 CHEMBL3677678 IC50 0.78 nM
CN(C)[C@@]1(C)C[C@H](C(=O)N2CCC(c3ccnn3-c3ccc(F)c(Cl)c3)CC2)[C@@H](c2ccc(F)cc2F)C1 CHEMBL2031596 IC50 0.8 nM
Cc1cc(C2CCN(C(=O)[C@@H]3C[C@@](C)(N(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(Cl)c(Cl)c2)n1 CHEMBL3655577 IC50 0.8 nM
C[C@H](NC(=O)[C@@H](NC(=O)C(C)(C)N)[C@@H](C)c1ccc(-c2ccccc2)cc1)c1ccc(Cl)cc1 CHEMBL1938502 IC50 0.9 nM
Cc1nc(C2CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(Cl)c(C)c2)n1 CHEMBL2024198 IC50 0.9 nM
Cc1cc(C2CCN(C(=O)[C@@H]3C[C@@](C)(N(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(F)c(Cl)c2)n1 CHEMBL2031590 IC50 0.9 nM
Cc1cc(C2CCN(C(=O)[C@@H]3C[C@@](C)(N(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2cc(Cl)ccc2Cl)n1 CHEMBL2031588 IC50 0.9 nM
O=C(NC(c1ccc(Cl)cc1)c1ccc(F)cn1)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1 CHEMBL3086041 IC50 0.95 nM
C[C@@H](c1ccc(-c2ccccc2)cc1)[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1259194 IC50 1.0 nM
C[C@H](NC(=O)[C@H](Cc1ccc(-c2ccccc2)cc1)NCC(C)(C)N)c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1950443 IC50 1.0 nM
CC(c1ccc(F)cn1)N1CCC2(CC1)OC(c1cc(Cl)ccn1)c1ccccc12 CHEMBL1951470 IC50 1.0 nM
Cc1cc(C2CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(Cl)c(C)c2)n1 CHEMBL2022785 IC50 1.0 nM
Cc1cc(C2CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(Cl)cc2)n1 CHEMBL2022789 IC50 1.0 nM
Cc1cc(C2CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2cc(Cl)ccc2F)n1 CHEMBL2023211 IC50 1.0 nM
Cn1nc(C2CCN(CCC(=O)N3CCC[C@H]3c3nc4cc(Cl)c(Cl)cc4[nH]3)CC2)cc1-c1ccncc1 CHEMBL1684306 IC50 1.1 nM
Cc1nc(C2CCN(C(=O)[C@@H]3C[C@@](C)(N(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(Cl)c(C)c2)n1 CHEMBL2031580 IC50 1.1 nM
CC(NC(=O)CCN1CCC(c2ccccc2)CC1)(c1ccncc1)c1ccc(Cl)cc1 CHEMBL1938523 IC50 1.2 nM
[O-][n+]1ccc(Cl)cc1C1OC2(CCN(Cc3ccc(OC(F)(F)F)cc3)CC2)c2ccccc21 CHEMBL1951468 IC50 1.2 nM
O=C([C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1)N1CC(c2ccccc2)(c2ccccc2)C1 CHEMBL3086029 IC50 1.2 nM
O=C(Cc1ccccc1C(F)(F)F)N1CCC(c2cc(-c3ccc(F)cc3)nn2-c2ncccn2)CC1 CHEMBL3912879 IC50 1.28 nM
O=C(CCN1CCC(c2ccccc2)CC1)NC(c1ccc(Cl)cc1)C(F)(F)F CHEMBL1938519 IC50 1.4 nM
Cc1cc(C2CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(Cl)c(F)c2)n1 CHEMBL2023208 IC50 1.4 nM
O=C(NC(c1ccncc1)c1ccc(F)cc1)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccccc1 CHEMBL3652602 IC50 1.4 nM
CC(C)[C@H](NC(=O)CCN1CCC(c2ccccc2)CC1)c1ccc(Cl)cc1 CHEMBL1938516 IC50 1.5 nM
O=S(=O)(c1ccc(OC(F)(F)F)cc1)N1CCC2(CC1)OC(c1cc(Cl)cc(Cl)c1)c1cccnc12 CHEMBL1951471 IC50 1.6 nM
Cc1nc(C2CCN(C(=O)[C@@H]3C[C@@](C)(N(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2cc(Cl)ccc2Cl)n1 CHEMBL2031582 IC50 1.6 nM
O=C(CCN1CCC(c2nc(-c3ccncc3)no2)CC1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684297 IC50 1.7 nM
C[C@@H](c1ccc(-c2ccccc2)cc1)[C@H](NC(=O)C(C)(C)N)C(=O)NC(c1ccc(Cl)cc1)C(F)(F)F CHEMBL1938508 IC50 1.7 nM
O=C(NC(c1ccc(F)cc1)c1ccc(F)cc1)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccccc1F CHEMBL3652600 IC50 1.7 nM
FC(F)(F)Oc1ccc(CN2CCC3(CC2)OC(c2cc(Cl)cc(Cl)c2)c2ccccc23)cc1 CHEMBL1951456 IC50 1.9 nM
CC(c1ccc(F)cn1)N1CCC2(CC1)OC(c1cc(Cl)cc(Cl)c1)c1cccnc12 CHEMBL1951473 IC50 1.9 nM
C[C@@H](c1ccc(-c2ccc(F)cc2)cc1)[C@H](NC(=O)C(C)(C)O)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1259208 IC50 2.0 nM
CC(C)(N)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1CCC[C@H]1c1ncc(C(C)(C)C)[nH]1 CHEMBL1259178 IC50 2.0 nM
C[C@@]1(N)C[C@H](C(=O)N2CCC(c3ccnn3-c3ccc(F)c(Cl)c3)CC2)[C@@H](c2ccc(F)cc2F)C1 CHEMBL2031597 IC50 2.0 nM
Cc1nc(C2CCN(C(=O)[C@@H]3C[C@@](C)(N(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(F)c(Cl)c2)n1 CHEMBL2031584 IC50 2.0 nM
Cc1cc(C(NC(=O)CCN2CCC(c3ccccc3)CC2)c2ccc(Cl)cc2)ccn1 CHEMBL1938524 IC50 2.1 nM
O=C(NC(c1ccc(Cl)cc1)C(F)(F)F)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1 CHEMBL3652597 IC50 2.1 nM
Cc1cc(C(NC(=O)[C@@H]2CC[C@@H](N3CCOCC3)C[C@H]2c2ccc(Br)cc2)c2ccc(Cl)cc2)ccn1 CHEMBL3086038 IC50 2.2 nM
CS(=O)(=O)c1ccc(-c2noc(C3CCN(CCC(=O)N4CCC[C@H]4c4nc5cc(Cl)c(Cl)cc5[nH]4)CC3)n2)cc1 CHEMBL1684301 IC50 2.3 nM
Fc1ccc(-c2nc(-c3ccccn3)c(C3CCN(CCc4ccccc4)CC3)s2)cc1 CHEMBL3677681 IC50 2.4 nM
C[C@@H](c1ccc(-c2ccccc2)cc1)[C@H](N)C(=O)NC(c1ccncc1)c1ccc(Cl)cc1 CHEMBL1938509 IC50 2.5 nM
O=C([C@@H]1CNC[C@H]1c1ccc(F)cc1F)N1CCC(c2ccnn2-c2ccc(F)c(Cl)c2)CC1 CHEMBL2024197 IC50 2.5 nM
O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1 CHEMBL3086048 IC50 2.5 nM
Cc1ccccc1[C@H]1C[C@@H](NCc2ccc(Cl)cc2)CC[C@@H]1C(=O)N1CC(c2ccccc2)(c2ccccc2)C1 CHEMBL3086045 IC50 2.5 nM
CO[C@@H](CN1CCC(c2nc(-c3ccc(F)cc3)nn2-c2ncccn2)CC1)c1ccccc1 CHEMBL3941702 IC50 2.58 nM
C[C@H](NC(=O)[C@@H](N)[C@@H](C)c1ccc(-c2ccccc2)cc1)c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1950445 IC50 2.6 nM
O=C(NC(c1ccc(Cl)cc1)c1ccc(Cl)cc1)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1 CHEMBL3086035 IC50 2.6 nM
O=C(CCN1CCC(c2nc(-c3ccccn3)no2)CC1)NC(c1ccncc1)c1ccc(Cl)cc1 CHEMBL1938496 IC50 2.7 nM
Cc1cc(C2CCN(C(=O)[C@@H]3C[C@@](C)(N)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2cc(Cl)ccc2Cl)n1 CHEMBL2031589 IC50 2.7 nM
O=C(NC(c1ccc(Cl)cc1)c1ccncc1Cl)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1 CHEMBL3086039 IC50 2.7 nM
CC(NC(=O)CCN1CCC(c2ccccc2)CC1)c1ccccc1-c1ccccc1 CHEMBL1938527 IC50 2.8 nM
Cc1cc(C2CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(F)c(F)c2)n1 CHEMBL2023205 IC50 2.8 nM
N#Cc1ccc([C@@H]2C[C@H](N3CCOCC3)CC[C@H]2C(=O)NC(c2ccc(F)cc2)c2ccc(F)cc2)cc1 CHEMBL3652601 IC50 2.9 nM
CC(C)(CN)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1259149 IC50 3.0 nM
C[C@H](NC(=O)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1)c1ccc(Cl)cc1 CHEMBL3086034 IC50 3.0 nM
O=C(CCN1CCC(c2ccccc2)CC1)NC(c1ccc(Cl)cc1)C(F)F CHEMBL1938518 IC50 3.2 nM
FC(F)(F)c1ccc(CN2CCC3(CC2)OC(c2cc(Cl)cc(Cl)c2)c2ccccc23)nc1 CHEMBL1951458 IC50 3.2 nM
FC(F)(F)Oc1ccc(CN2CCC3(CC2)OC(c2cc(Cl)cc(Cl)c2)c2cccnc23)cc1 CHEMBL1951461 IC50 3.2 nM
Cn1nc(-c2ccc(F)cc2)cc1C1(c2ccccn2)CCN(CCc2ccccc2)CC1 CHEMBL3237393 IC50 3.3 nM
FC(F)(F)Oc1ccc(CN2CCC3(CC2)OC(c2cc(Cl)cc(Cl)c2)c2ccncc23)cc1 CHEMBL1951462 IC50 3.4 nM
Fc1ccc([C@@H]2CN(CCc3ccccc3)CC[C@H]2c2cc(-c3ccc(Cl)cc3)n[nH]2)cc1 CHEMBL3237377 IC50 3.5 nM
O=C(CCN1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684300 IC50 3.7 nM
C[C@@H](c1ccc(-c2ccccc2)cc1)[C@H](NC(=O)C(C)(C)N)C(=O)NC(c1ccc(Cl)cc1)C(F)F CHEMBL1938506 IC50 3.8 nM
O=C(CCN1CCC(c2ccccc2)CC1)NC(c1ccncc1)c1ccc(F)cc1 CHEMBL1938521 IC50 3.8 nM
CC(C)(N)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1259118 IC50 4.0 nM
CC(C)(O)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1CCC[C@H]1c1ncc(C(C)(C)C)[nH]1 CHEMBL1259179 IC50 4.0 nM
Cc1cc(C2CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(F)cc2F)n1 CHEMBL2023206 IC50 4.3 nM
c1ccc(CCN2C[C@H](c3[nH]c(-c4ccccc4)nc3-c3ccccn3)CC[C@H]2c2ccccc2)cc1 CHEMBL3677680 IC50 4.4 nM
FC(F)(F)Oc1ccc(CN2CCC3(CC2)OC(c2cc(Cl)cc(Cl)c2)c2cnccc23)cc1 CHEMBL1951463 IC50 4.5 nM
O=C(NC(c1ccc(Cl)cc1)c1cnccn1)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1 CHEMBL3086042 IC50 4.6 nM
CCn1nc(-c2ccncc2)cc1C1CCN(CCC(=O)N2CCC[C@H]2c2nc3cc(Cl)c(Cl)cc3[nH]2)CC1 CHEMBL1684305 IC50 4.7 nM
Cc1nc(C2CCN(C(=O)[C@H]3CN(C(C)(C)C)C[C@@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(Cl)c(C)c2)n1 CHEMBL2024199 IC50 4.9 nM
Cc1cc(C2CCN(C(=O)[C@@H]3CNC[C@H]3c3ccc(F)cc3F)CC2)n(-c2cc(Cl)ccc2Cl)n1 CHEMBL2024195 IC50 4.9 nM
CC(C)(N)CC(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1259162 IC50 5.0 nM
C[C@@H](c1ccccc1)[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1259207 IC50 5.0 nM
Cn1cc(-c2ccc(C[C@H](NC(=O)C(C)(C)N)C(=O)N3CCC[C@H]3c3nc4cc(Cl)c(Cl)cc4[nH]3)cc2)ccc1=O CHEMBL1259222 IC50 5.0 nM
C[C@H](NC(=O)CCN1CCN(c2cccc(F)c2)CC1)c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1950309 IC50 5.0 nM
O=C(CCN1CCC(c2ccccc2)CC1)NC(c1ccc(Cl)cc1)c1ccc(Cl)cc1 CHEMBL1938520 IC50 5.2 nM
C[C@]12N[C@H](Cc3ccccc31)c1ccccc12 CHEMBL284237 IC50 5.3 nM
N#Cc1ccc(C(NC(=O)[C@@H]2CC[C@@H](N3CCOCC3)C[C@H]2c2ccc(Br)cc2)c2ccc(Cl)cc2)cc1 CHEMBL3652598 IC50 5.4 nM
C[C@H](NC(=O)[C@@H](NC(=O)C(C)(C)O)[C@@H](C)c1ccc(-c2cn[nH]c2)cc1)c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1950314 IC50 5.6 nM
Cc1cc(C2CCN(C(=O)[C@@H]3CNC[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(Cl)c(Cl)c2)n1 CHEMBL2024194 IC50 5.6 nM
C[C@]1(N)C[C@H](C(=O)N2CCC(c3ccnn3-c3ccc(F)c(Cl)c3)CC2)[C@@H](c2ccc(F)cc2F)C1 CHEMBL2031598 IC50 5.7 nM
Cc1nc(C2CCN(C(=O)[C@@H]3C[C@@H](N(C)CCC(F)(F)F)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(Cl)c(C)c2)n1 CHEMBL3655574 IC50 5.9 nM
COC(=O)N[C@H]1CC[C@H](Nc2cc(N[C@@H](C)c3ccc(Cl)cc3)ncn2)CC1 CHEMBL1949687 IC50 6.0 nM
Cc1nc(C2CCN(C(=O)[C@@H]3C[C@@](C)(N)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2cc(Cl)ccc2Cl)n1 CHEMBL2031583 IC50 6.0 nM
Cc1cc(C2CCN(C(=O)[C@@H]3C[C@@](C)(N4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(F)c(Cl)c2)n1 CHEMBL3655576 IC50 6.3 nM
Cc1cc(C2CCN(C(=O)[C@@H]3C[C@@](C)(N)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(F)c(Cl)c2)n1 CHEMBL2031591 IC50 6.4 nM
Cc1nc(C2CCN(C(=O)[C@@H]3C[C@@H](N(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(Cl)c(C)c2)n1 CHEMBL2031367 IC50 6.4 nM
C[C@H](NC(=O)[C@H](Cc1cccc(C#N)c1)NC(=O)C(C)(C)N)c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1950441 IC50 6.6 nM
Cc1cc(C2CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2cccc(Cl)c2)n1 CHEMBL2022788 IC50 6.7 nM
CCn1nc(Cc2ccc3c(c2)OCO3)cc1C1CCN(CCC(=O)N2CCC[C@H]2c2nc3cc(Cl)c(Cl)cc3[nH]2)CC1 CHEMBL1684310 IC50 7.0 nM
Cn1nc(-c2ccc(F)cc2)cc1C1(c2ccccc2)CCN(CCc2ccccc2)CC1 CHEMBL3237391 IC50 7.0 nM
O=C(CCN1CCC(c2nc(-c3ccccn3)no2)CC1)NC(c1ccncc1)c1ccc(F)cc1 CHEMBL1938495 IC50 7.6 nM
Cc1cc(C2CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2cc(F)ccc2Cl)n1 CHEMBL2023212 IC50 7.8 nM
O=S(=O)(c1ccc(OC(F)(F)F)cc1)N1CCC2(CC1)OC(c1ccccn1)c1ccccc12 CHEMBL3670946 IC50 7.8 nM
Clc1ccc(-c2nc(-c3ncccn3)c([C@@H]3CC[C@H](c4ccccc4)NC3)[nH]2)cc1 CHEMBL3677684 IC50 8.0 nM
CC(C)(O)C(c1ccccc1)N1CCC2(CC1)OC(c1cc(Cl)cc(Cl)c1)c1cccnc12 CHEMBL1951477 IC50 8.3 nM
C[C@H](NC(=O)CCN1CCC(c2ccccc2)CC1)c1ccc(Br)cc1 CHEMBL1938515 IC50 8.4 nM
CS(=O)(=O)c1ccc(-c2noc(C3CCN(CCC(=O)N4CCC[C@H]4c4nc5cc(Cl)c(Cl)cc5[nH]4)C(=O)C3)n2)cc1 CHEMBL1684303 IC50 8.5 nM
COc1ccc(C[C@H](NC(=O)C(C)(C)N)C(=O)N2CC[C@H]2c2nc3cc(Cl)c(Cl)cc3[nH]2)cc1 CHEMBL1259134 IC50 9.0 nM
CC(c1ccc(F)cn1)N1CCC2(CC1)OC(c1cc(Cl)ccn1)c1cccnc12 CHEMBL1951472 IC50 9.5 nM
Cc1nc(C2CCN(C(=O)[C@@H]3CC(N4CCC(F)(F)C4)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(Cl)c(C)c2)n1 CHEMBL3655575 IC50 9.8 nM
O=C(CCN1CCC(c2ccccc2)CC1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684277 IC50 10.0 nM
C[C@H](NC(=O)CCN1CCC(c2ccccc2)CC1)c1ccc(Cl)cc1 CHEMBL1938514 IC50 10.0 nM
C[C@H](NC(=O)CCN1CCC(c2cccc(F)c2)CC1)c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1950307 IC50 10.0 nM
Cc1nc(C2CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(F)c(F)c2)n1 CHEMBL2022781 IC50 10.0 nM
CC(C)(C)N1C[C@@H](C(=O)N2CCC(c3nnnn3-c3ccc(Cl)cc3)CC2)[C@H](c2ccc(F)cc2F)C1 CHEMBL2022791 IC50 10.0 nM
O=C([C@@H]1CC[C@@H](NCc2ccc(Cl)cc2)C[C@H]1c1ccc(F)cc1)N1CC(c2ccccc2)(c2ccccc2)C1 CHEMBL3237373 IC50 10.4 nM
Cc1cc(C2CCN(C(=O)[C@@H]3CNC[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(F)c(Cl)c2)n1 CHEMBL2024196 IC50 10.7 nM
CC(NC(=O)CCN1CCC(c2nc(-c3ccccn3)no2)CC1)(c1ccncc1)c1ccc(Cl)cc1 CHEMBL1938499 IC50 11.0 nM
Cn1cc(C(NC(=O)CCN2CCC(c3ccccc3)CC2)c2ccc(Cl)cc2)cn1 CHEMBL1938526 IC50 11.0 nM
Fc1ccc(CN2CCC3(CC2)OC(c2cc(Cl)cc(Cl)c2)c2ccccc23)nc1 CHEMBL1951457 IC50 11.0 nM
Cc1nc(C2CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(Cl)cc2)n1 CHEMBL2024201 IC50 11.0 nM
Cc1nc(C2CCN(C(=O)[C@@H]3CNC[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(Cl)c(Cl)c2)n1 CHEMBL2023214 IC50 11.0 nM
CC(C)(N)C(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1)C(C)(C)c1ccccc1 CHEMBL1259238 IC50 12.0 nM
O=C(CCN1CCC(c2nc(-c3ccccn3)no2)CC1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684295 IC50 12.0 nM
Cc1cc(C2CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(F)cc2)n1 CHEMBL2023203 IC50 12.0 nM
C[C@H](NC(=O)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1)c1ccc(F)cc1 CHEMBL3086032 IC50 12.0 nM
c1ccc(-c2nc(-c3ccncc3)c([C@H]3CC[C@H](c4ccccc4)NC3)o2)cc1 CHEMBL3677675 IC50 12.0 nM
Cc1nc(C2CCN(C(=O)[C@@H]3C[C@@](C)(N)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(F)c(Cl)c2)n1 CHEMBL2031585 IC50 12.1 nM
Cc1nc(C2CCN(C(=O)[C@@H]3C[C@H](N(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(Cl)c(C)c2)n1 CHEMBL2031579 IC50 12.5 nM
O=C(CCN1CCC(c2nc(-c3cnccn3)no2)CC1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684298 IC50 13.0 nM
Cc1nc(C2CCN(C(=O)[C@@H]3CNC[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(F)c(Cl)c2)n1 CHEMBL2024193 IC50 13.0 nM
OC(CN1CC[C@@H](c2cc(-c3ccc(Cl)cc3)n[nH]2)[C@H](c2ccc(F)cc2)C1)c1ccccc1 CHEMBL3237381 IC50 13.0 nM
CN[C@@H]1C[C@@H](C(=O)N2CCC(c3nc(C)nn3-c3ccc(Cl)c(C)c3)CC2)[C@H](c2ccc(F)cc2F)C1 CHEMBL3655573 IC50 13.9 nM
C[C@H](NC(=O)CCN1CCC(c2ccccc2)CC1)c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1950311 IC50 14.0 nM
Cc1nc(C2CCN(C(=O)[C@@H]3CNC[C@H]3c3ccc(F)cc3F)CC2)n(-c2cc(Cl)ccc2Cl)n1 CHEMBL2023215 IC50 14.0 nM
CC(C)(CCCC(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1)N1CCC(c2nc(-c3ccccn3)no2)CC1 CHEMBL1684304 IC50 15.0 nM
O=C(CCN1CCC(c2nc(-c3ccccn3)no2)CC1)NC(c1ccccc1)c1ccc(Cl)cc1 CHEMBL1938492 IC50 15.0 nM
C[C@H](NC(=O)[C@@H](N)[C@@H](C)c1ccc(-c2ccccc2)cc1)c1ccc(Cl)cc1 CHEMBL1938501 IC50 15.0 nM
C[C@H](Nc1cc(N[C@H]2CC[C@H](NS(C)(=O)=O)CC2)ncn1)c1ccc(Cl)cc1 CHEMBL1950919 IC50 15.0 nM
FC(F)(F)Oc1ccc(CN2CCC3(CC2)OC(c2cc(Cl)ccn2)c2cccnc23)cc1 CHEMBL1951469 IC50 15.6 nM
S=C=Nc1cccc(C2(N3CCCCC3)CCCCC2)c1 CHEMBL41541 Ki 16.0 nM
O=C(CCN1CCN(c2ccccc2)CC1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684281 IC50 16.0 nM
C[C@H](NC(=O)CCN1CCN(c2ccc(F)cc2)CC1)c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1950310 IC50 16.0 nM
CCN(CC)CC(=O)N[C@@H]1CC[C@@H](C(=O)NC(c2ccc(F)cc2)c2ccc(F)cc2)[C@H](c2ccc(Br)cc2)C1 CHEMBL3086028 IC50 16.7 nM
O=C(O)c1ccc(-c2noc(C3CCN(CCC(=O)N4CCC[C@H]4c4nc5cc(Cl)c(Cl)cc5[nH]4)CC3)n2)cc1 CHEMBL1684302 IC50 17.0 nM
O=C(CCN1CCC(c2nc(-c3ccccn3)no2)CC1)NC(c1ccc(Cl)cc1)C(F)(F)F CHEMBL1938491 IC50 17.0 nM
CC(C)C(NC(=O)[C@@H](NC(=O)C(C)(C)N)[C@@H](C)c1ccc(-c2ccccc2)cc1)c1ccc(Cl)cc1 CHEMBL1938504 IC50 17.0 nM
CN(C(=O)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1)C(c1ccccc1)c1ccccc1 CHEMBL3086030 IC50 17.0 nM
O=C(CCN1CCC(c2cc[nH]n2)CC1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684282 IC50 18.0 nM
O=C(CCN1CCC(c2nc(-c3cccnc3)no2)CC1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684296 IC50 18.0 nM
Cc1cc(C2CCN(C(=O)[C@H]3C[C@@](C)(N)C[C@@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(F)c(Cl)c2)n1 CHEMBL2031594 IC50 18.0 nM
O=C(CCN1CCC(c2nc(-c3ncccn3)no2)CC1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684299 IC50 19.0 nM
c1csc(C2(N3CCCCC3)CCCCC2)c1 CHEMBL279676 IC50 20.0 nM
CC(C)(O)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1CCC[C@H]1c1nc2cc(F)c(F)cc2[nH]1 CHEMBL1259135 IC50 21.0 nM
C[C@@H](c1ccccc1)[C@H](NC(=O)C(C)(C)O)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1259221 IC50 21.0 nM
O=C(CCN1CCC(c2ccncc2)CC1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684291 IC50 21.0 nM
CC(C)C(NC(=O)CCN1CCC(c2nc(-c3ccccn3)no2)CC1)c1ccc(Cl)cc1 CHEMBL1938489 IC50 21.0 nM
C[C@@H](c1ccc(-c2ccccc2)cc1)[C@H](N)C(=O)NC(c1ccc(Cl)cc1)C(F)F CHEMBL1938505 IC50 21.0 nM
COc1ccc(C2CN(c3cc(N4CCC[C@H]4c4nc5cc(Cl)c(Cl)cc5[nH]4)ncn3)CCO2)cc1 CHEMBL1950904 IC50 21.0 nM
CS(=O)(=O)N1CCC(N2CCC(c3cc(-c4ccc(Cl)cc4)nn3-c3ccccc3)CC2)C1 CHEMBL3896015 IC50 21.06 nM
CC(C)(Cc1ccc(-c2cccc(Cl)c2Cl)cc1)C(=O)N1CC(F)(F)C[C@H]1c1ncc(-c2cccc(Br)c2)[nH]1 CHEMBL1259085 IC50 22.0 nM
O=C(CCN1CCC(c2cn[nH]c2)CC1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684284 IC50 22.0 nM
Clc1cc(Cl)cc(C2OC3(CCN(Cc4cc5ccccc5o4)CC3)c3ccccc32)c1 CHEMBL1951455 IC50 23.0 nM
N#Cc1cccc(-c2ccc(CCC(=O)N3C[C@H](O)C[C@H]3c3ncc(-c4cccc(Cl)c4)[nH]3)cc2)c1 CHEMBL1259104 IC50 24.0 nM
O=C(CCN1CCC(c2cnccn2)CC1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684294 IC50 24.0 nM
Cc1cc(C2CCN(C(=O)[C@@H]3C[C@](C)(N)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(F)c(Cl)c2)n1 CHEMBL2031593 IC50 24.7 nM
O=C(CCN1CCCC(c2ccccc2)CC1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684278 IC50 25.0 nM
CCn1nc(Cc2ccc(F)cc2)cc1C1CCN(CCC(=O)N2CCC[C@H]2c2nc3cc(Cl)c(Cl)cc3[nH]2)CC1 CHEMBL1684309 IC50 25.0 nM
CCN(CC)CCOC(=O)C1(c2ccccc2)CCCC1 CHEMBL61946 Ki 26.0 nM
O=C(CCN1CCC(c2nc(-c3ccccn3)no2)CC1)NC(c1ccccc1)c1ccncc1 CHEMBL1938494 IC50 26.0 nM
Cc1cc(C(NC(=O)CCN2CCC(c3nc(-c4ccccn4)no3)CC2)c2ccc(Cl)cc2)ccn1 CHEMBL1938500 IC50 26.0 nM
O=C(CCN1CCC(c2cc(-c3ccncc3)[nH]n2)CC1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684308 IC50 27.0 nM
FC(F)(F)c1ccc(C2CCCN(c3cc(N4CCC[C@H]4c4nc5cc(Cl)c(Cl)cc5[nH]4)ncn3)C2)cc1 CHEMBL1950900 IC50 28.0 nM
C[C@@]1(N)C[C@@H](C(=O)N2CCC(c3ncnn3-c3ccc(F)c(Cl)c3)CC2)[C@H](c2ccc(F)cc2F)C1 CHEMBL2031587 IC50 28.0 nM
Fc1ccc(-c2nc(C3C4CN(CCc5ccccc5)CC43)n(-c3ncccn3)n2)cc1 CHEMBL3976324 IC50 28.6 nM
O=C(NC(c1ccccc1)c1ccccc1)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccccc1 CHEMBL3086047 IC50 29.0 nM
O=C(CCN1CCC(n2ncnn2)CC1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684289 IC50 30.0 nM
Fc1ccc(-c2cc(C3(c4ccccc4)CCN(CCc4ccccc4)CC3)[nH]n2)cc1 CHEMBL3237390 IC50 30.0 nM
C[C@@H](c1ccc(Cl)cc1)N(C)c1cc(N2CCCC(C(C)(C)O)C2)ncn1 CHEMBL1950916 IC50 31.0 nM
CCn1nc(-c2ccc(Cl)cc2)cc1C1CCN(CCc2ccccc2)CC1 CHEMBL3938459 IC50 31.78 nM
CCN(CC)CCOCCOC(=O)C1(c2ccccc2)CCCC1 CHEMBL73234 IC50 32.0 nM
Cn1nc(C2CCN(CCC(=O)N3CCC[C@H]3c3nc4cc(Cl)c(Cl)cc4[nH]3)CC2)cc1-c1cccnc1 CHEMBL1684307 IC50 32.0 nM
C[C@@H](c1ccc(-c2ccccc2)cc1)[C@H](N)C(=O)NC(c1ccc(Cl)cc1)C(F)(F)F CHEMBL1938507 IC50 32.0 nM
Clc1cc2nc([C@@H]3CCCN3c3cc(N4CCC(Cn5cccn5)CC4)ncn3)[nH]c2cc1Cl CHEMBL1950905 IC50 32.0 nM
Clc1ccc(-c2nc(-c3ccccn3)c(C3CCN(CCc4ccccc4)CC3)s2)cc1 CHEMBL3677682 IC50 32.0 nM
O=C(CCN1CCC(c2nc(-c3ccccn3)no2)CC1)NC(c1ccc(Cl)cc1)c1ccc(Cl)cc1 CHEMBL1938493 IC50 33.0 nM
Cc1nc(C2CCN(C(=O)[C@@H]3CNC[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(Cl)cc2)n1 CHEMBL2023213 IC50 33.0 nM
O=C(CCN1CCC(n2cccn2)CC1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684283 IC50 34.0 nM
c1ccc(CCN2CCC(c3sc(-c4ccccc4)nc3-c3ccccc3)CC2)cc1 CHEMBL3677683 IC50 35.0 nM
O=C(NC(c1ccc(Cl)cc1)c1ncccn1)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1 CHEMBL3086043 IC50 36.0 nM
C[C@@H](c1ccccc1)[C@H](NC(=O)C(C)(C)N)C(=O)N1CC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1259195 IC50 37.0 nM
O=C(CCN1CCC(c2nc(-c3ccccn3)no2)CC1)NC(c1ccc(Cl)cc1)c1cccnc1 CHEMBL1938497 IC50 37.0 nM
C[C@H](NC(=O)CCN1CCN(c2ccccc2F)CC1)c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1950308 IC50 38.0 nM
Clc1ccc(-c2cc(C3CCN(CCc4ccccc4)CC3)nn2-c2ccncn2)cc1 CHEMBL3894833 IC50 38.36 nM
Fc1ccc([C@H]2CN(CCc3ccccc3)CC[C@H]2c2cc(-c3ccc(Cl)cc3)n[nH]2)cc1 CHEMBL3237380 IC50 40.0 nM
Fc1ccc([C@@H]2CN(CCC(F)(F)F)CC[C@H]2c2cc(-c3ccc(Cl)cc3)n[nH]2)cc1 CHEMBL3237384 IC50 40.0 nM
Clc1cc(Cl)cc(C2OC3(CCN(Cc4ccc(N5CCCC5)cn4)CC3)c3ccccc32)c1 CHEMBL1951459 IC50 41.0 nM
O=C(CCN1CCC(n2nccn2)CC1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684287 IC50 42.0 nM
CC(C)(O)C1CCCN(c2cc(N3CCC[C@H]3c3nc4cc(Cl)c(Cl)cc4[nH]3)ncn2)C1 CHEMBL1950908 IC50 42.0 nM
C[C@H](Nc1cc(N2CCCC(C(C)(C)O)C2)ncn1)c1ccc(Cl)cc1 CHEMBL1950912 IC50 43.0 nM
Cc1ccccc1[C@H]1C[C@H](NCc2ccc(Cl)cc2)CC[C@@H]1C(=O)N1CC(c2ccccc2)(c2ccccc2)C1 CHEMBL3086046 IC50 43.0 nM
O=C(CCN1CCC(c2ncccn2)CC1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684293 IC50 44.0 nM
C[C@H](Nc1cc(N2CCCC(N3CCc4c(cccc4-c4cccnc4)C3)C2)ncn1)c1ccc(Cl)cc1 CHEMBL1950917 IC50 44.0 nM
Cc1nc(C2CCN(C(=O)[C@@H]3C[C@](C)(N)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(F)c(Cl)c2)n1 CHEMBL2031586 IC50 44.3 nM
Cc1cc(C(NC(=O)[C@@H](N)[C@@H](C)c2ccc(-c3ccccc3)cc2)c2ccc(Cl)cc2)ccn1 CHEMBL1938511 IC50 45.0 nM
C[C@H](NC(=O)CCc1ccc(-c2cccnc2)cc1)c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1950448 IC50 48.0 nM
Clc1cc2nc([C@@H]3CCCN3c3cc(N4CCCC(N5CCc6c(cccc6-c6cccnc6)C5)C4)ncn3)[nH]c2cc1Cl CHEMBL1950909 IC50 48.0 nM
O=C(CCc1ccc(-c2ccc(Cl)cc2)cc1)N1CCC[C@H]1c1ncc(-c2ccccc2)[nH]1 CHEMBL1259046 IC50 49.0 nM
Cc1nc(C2CCN(C(=O)[C@@H]3C[C@@](C)(N)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(Cl)c(C)c2)n1 CHEMBL2031581 IC50 49.9 nM
C[C@H](Nc1cc(N[C@H]2CC[C@H](c3ccccc3)CC2)ncn1)c1ccc(Cl)cc1 CHEMBL1950918 IC50 52.0 nM
CC(C)C(NC(=O)[C@@H](N)[C@@H](C)c1ccc(-c2ccccc2)cc1)c1ccc(Cl)cc1 CHEMBL1938503 IC50 53.0 nM
CC(C)(N)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1259119 IC50 54.0 nM
FC(F)(F)Oc1ccc(CN2CCC3(CC2)OC(c2ccc(Cl)cn2)c2ccccc23)cc1 CHEMBL1951466 IC50 54.0 nM
Cc1ccc(-c2ccc(CCC(=O)N3CCC[C@H]3c3ncc(-c4ccccc4)[nH]3)cc2)cc1 CHEMBL1259027 IC50 56.0 nM
OC1(c2ccccc2)CCN(c2cc(N3CCC[C@H]3c3nc4cc(Cl)c(Cl)cc4[nH]3)ncn2)C1 CHEMBL1950907 IC50 58.0 nM
C[C@H](NC(=O)CCc1ccc(-c2ccccc2)cc1)c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1950451 IC50 60.0 nM
O=C(CCN1CCC(c2ncon2)CC1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684290 IC50 64.0 nM
O=C(CCN1CCC(c2nc(-c3ccccn3)no2)CC1)NC(c1ccc(Cl)cc1)c1ccccn1 CHEMBL1938498 IC50 64.0 nM
O=C(O)C(c1ccc(OC(F)(F)F)cc1)N1CCC2(CC1)OC(c1cc(Cl)cc(Cl)c1)c1cccnc12 CHEMBL3670945 IC50 65.0 nM
CC(C)(C)CN1CC[C@@H](c2cc(-c3ccc(Cl)cc3)n[nH]2)[C@H](c2ccc(F)cc2)C1 CHEMBL3237386 IC50 66.0 nM
CC(C)(C)OC(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1CCC[C@H]1C(=O)c1nc2ccccc2[nH]1 CHEMBL1259218 IC50 68.0 nM
O=C(CN1CC[C@@H](c2cc(-c3ccc(Cl)cc3)n[nH]2)[C@H](c2ccc(F)cc2)C1)c1ccccc1 CHEMBL3237382 IC50 69.0 nM
O=C(CCN1CCC(n2cncn2)CC1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684288 IC50 71.0 nM
CC(C)(C)c1ccc(-c2ccc(CCC(=O)N3CCC[C@H]3c3ncc(-c4ccccc4)[nH]3)cc2)cc1 CHEMBL1259047 IC50 72.0 nM
O=C(CCc1ccc(-c2ccc(Cl)c(F)c2)cc1)N1CCC[C@H]1c1ncc(-c2ccccc2)[nH]1 CHEMBL1259066 IC50 73.0 nM
Cc1cc(-n2nc(C3CCN(C(=O)[C@@H]4CN(C(C)(C)C)C[C@H]4c4ccc(F)cc4F)CC3)nc2C)ccc1Cl CHEMBL2024200 IC50 73.0 nM
Fc1ccc([C@@H]2CN(CCc3ccc(Cl)cc3)CC[C@H]2c2cc(-c3ccc(Cl)cc3)n[nH]2)cc1 CHEMBL3237376 IC50 74.0 nM
CC(C)(Cc1ccc(-c2ccccc2)cc1)C(=O)N1CCC[C@H]1c1ncc(-c2cccc(F)c2)[nH]1 CHEMBL1259069 IC50 79.0 nM
Cc1cc(C(NC(=O)CCN2CCC(c3ccccc3)CC2)c2ccc(Cl)cc2)cc(C)n1 CHEMBL1938525 IC50 79.0 nM
C[C@H](NC(=O)CCN1CCC(c2ccccc2)CC1)c1ccccc1 CHEMBL1938513 IC50 80.0 nM
O=S(=O)(c1ccc(N2CCC(c3cc(-c4ccc(Cl)cc4)nn3-c3ncccn3)CC2)nc1)N1CCOCC1 CHEMBL3924023 IC50 80.18 nM
FC(F)(F)Oc1ccc(CN2CCC3(CC2)OC(c2ccccn2)c2ccccc23)cc1 CHEMBL1951467 IC50 84.0 nM
Clc1cc(Cl)cc(C2OC3(CCN(Cc4ccc(N5CCCC5)nc4)CC3)c3ncccc32)c1 CHEMBL3670943 IC50 89.0 nM
O=C(N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1CCC[C@H]1C(=O)c1nc2ccccc2[nH]1)OCC1c2ccccc2-c2ccccc21 CHEMBL1256279 IC50 90.0 nM
c1ccc(C2(N3CCCCC3)CCCCC2)cc1 CHEMBL275528 IC50 91.0 nM
FC(F)(F)c1cccc(C2CCCN(c3cc(N4CCC[C@H]4c4nc5cc(Cl)c(Cl)cc5[nH]4)ncn3)C2)c1 CHEMBL1950899 IC50 91.0 nM
Clc1cc2nc([C@@H]3CCCN3c3cc(N4CCC(c5ccccn5)C4)ncn3)[nH]c2cc1Cl CHEMBL1950906 IC50 91.0 nM
Fc1ccc([C@@H]2CN(CCc3ccccc3)CC[C@@H]2c2cc(-c3ccc(Cl)cc3)n[nH]2)cc1 CHEMBL3237378 IC50 92.0 nM
O=C(CCN1CCC(c2ccncn2)CC1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684292 IC50 93.0 nM
CC(C)(C)N1C[C@@H](C(=O)N2CCC(c3cc(C(F)(F)F)nn3-c3ccc(Cl)cc3)CC2)[C@H](c2ccc(F)cc2F)C1 CHEMBL2022790 IC50 100.0 nM
C[C@H](NC(=O)[C@@H](N)Cc1cccc(C#N)c1)c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1950442 IC50 102.0 nM
O=C(CCN1CCC(c2nc(-c3ccccn3)no2)CC1)NC(c1ccc(Cl)cc1)C(F)F CHEMBL1938490 IC50 104.0 nM
Clc1ccc(-c2cc(C3(c4ccccc4)CCN(CCc4ccccc4)CC3)[nH]n2)cc1 CHEMBL3237389 IC50 105.0 nM
Fc1ccc([C@H]2CN(CCc3ccccc3)CC[C@@H]2c2cc(-c3ccc(Cl)cc3)n[nH]2)cc1 CHEMBL3237379 IC50 114.0 nM
Clc1ccc(-c2nc(-c3ncccn3)c([C@@H]3CC[C@@H](c4ccccc4)NC3)[nH]2)cc1 CHEMBL3677677 IC50 114.0 nM
O=C(CCc1ccc(-c2ccccc2Cl)cc1)N1CCC[C@H]1c1ncc(-c2ccccc2)[nH]1 CHEMBL1259028 IC50 122.0 nM
O=C(CCN1CCC(c2c[nH]cn2)CC1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684285 IC50 129.0 nM
Cc1ccc([C@H](C)Nc2cc(N3CCCC(C(C)(C)O)C3)ncn2)cc1 CHEMBL1950910 IC50 130.0 nM
O=C(CCN1CC(c2ccccc2)C1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684280 IC50 141.0 nM
Fc1ccc([C@@H]2CN(Cc3ccc(Cl)cc3)CC[C@H]2c2cc(-c3ccc(Cl)cc3)n[nH]2)cc1 CHEMBL3237383 IC50 150.0 nM
CC(C)N1CC[C@@H](c2cc(-c3ccc(Cl)cc3)n[nH]2)[C@H](c2ccc(F)cc2)C1 CHEMBL3237387 IC50 150.0 nM
C[C@H](NC(=O)CCN1CCC(c2nc(-c3ccccn3)no2)CC1)c1ccc(Cl)cc1 CHEMBL1938488 IC50 151.0 nM
O=C(CCN1CCC(n2ccnc2)CC1)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1684286 IC50 155.0 nM
O=C(CCc1ccc(-c2ccccc2)cc1)N1CCC[C@H]1c1ncc(-c2cccc(F)c2)[nH]1 CHEMBL1259068 IC50 158.0 nM
C[C@H](NC(=O)[C@@H](N)Cc1ccc(-c2ccccc2)cc1)c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1950446 IC50 160.0 nM
FC(F)(F)Oc1ccc(CN2CCC3(CC2)OC(c2cc(Cl)cc(Cl)c2)c2ncccc23)cc1 CHEMBL1951464 IC50 169.0 nM
CC(C)(NC(=O)CCN1CCC(c2ccccc2)CC1)c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1950312 IC50 181.0 nM
FC(F)(F)c1ccccc1C1CCCN(c2cc(N3CCC[C@H]3c3nc4cc(Cl)c(Cl)cc4[nH]3)ncn2)C1 CHEMBL1950898 IC50 190.0 nM
Cc1ccccc1C1CC(NCc2ccc(Cl)cc2)CCC1C(=O)N1CC(c2ccccc2)(c2ccccc2)C1 CHEMBL3086044 IC50 198.0 nM
CC(C)[C@@H](NC(=O)CCN1CCC(c2ccccc2)CC1)c1ccc(Cl)cc1 CHEMBL1938517 IC50 199.0 nM
OCC(c1ccccc1)N1CCC2(CC1)OC(c1cc(Cl)cc(Cl)c1)c1cccnc12 CHEMBL1951475 IC50 200.0 nM
O=C(c1nc2ccccc2[nH]1)[C@@H]1CCCN1C(=O)CCc1ccc(-c2ccccc2)cc1 CHEMBL1258992 IC50 223.0 nM
O=C(CCc1ccc(-c2ccccc2)cc1)N[C@@H](CO)c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1950449 IC50 225.0 nM
CN1CCN(c2ccc(CN3CCC4(CC3)OC(c3cc(Cl)cc(Cl)c3)c3ccccc34)nc2)CC1 CHEMBL3670944 IC50 235.0 nM
O=C(N[C@@H](CCCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)c1nc2ccccc2[nH]1)OCC1c2ccccc2-c2ccccc21 CHEMBL1256277 IC50 240.0 nM
Clc1cc2nc([C@@H]3CCCN3c3cc(N4CCO[C@H](c5ccccc5)C4)ncn3)[nH]c2cc1Cl CHEMBL1950903 IC50 241.0 nM
Clc1ccc(-c2cc([C@@H]3CC[C@@H](N4CCOCC4)C[C@H]3c3ccc(Br)cc3)[nH]n2)cc1 CHEMBL3237371 IC50 270.0 nM
Clc1cc2nc([C@@H]3CCCN3c3cc(N4CCO[C@@H](c5ccccc5)C4)ncn3)[nH]c2cc1Cl CHEMBL1950902 IC50 286.0 nM
CCCC[C@H](NC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)c1nc2ccccc2s1 CHEMBL1259114 IC50 300.0 nM
O=C(CCc1ccc(-c2ccc3c(c2)OCO3)cc1)N1CCC[C@H]1c1ncc(-c2ccccc2)[nH]1 CHEMBL1259067 IC50 300.0 nM
Cn1nc(C2(c3ccccc3)CCN(CCc3ccccc3)CC2)cc1-c1ccc(F)cc1 CHEMBL3237392 IC50 300.0 nM
Cc1cccc2[nH]c([C@@H]3[C@@H]4C[C@@H]4CN3C(=O)COc3ccc(-c4ccccc4)cc3)nc12 CHEMBL1259103 IC50 308.0 nM
C[C@H](NC(=O)CCN1CCC(c2nc(-c3ccccn3)no2)CC1)c1ccc(F)cc1 CHEMBL1938486 IC50 313.0 nM
Cc1cc(C2CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2cc(F)cc(F)c2)n1 CHEMBL2023204 IC50 315.0 nM
Clc1cc2nc([C@@H]3CCCN3c3cc(N4CCC(Cc5ccccc5)C4)ncn3)[nH]c2cc1Cl CHEMBL1950901 IC50 333.0 nM
Cc1ccccc1-c1ccc(CCC(=O)N2CCC[C@H]2c2ncc(-c3ccccc3)[nH]2)cc1 CHEMBL1259010 IC50 352.0 nM
CC(C)(NC(=O)CCc1ccc(-c2ccccc2)cc1)c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1950450 IC50 374.0 nM
CC(C)(C)CC(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1CCC[C@H]1C(=O)c1nc2ccccc2[nH]1 CHEMBL1259234 IC50 399.0 nM
O=C(CCN1CCC(c2ccccc2)CC1)NCc1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1950313 IC50 427.0 nM
Cc1ccccc1-c1cnc([C@@H]2CCCN2C(=O)COc2ccc(-c3ccccc3)cc2)[nH]1 CHEMBL1259084 IC50 432.0 nM
CC(C)(NC(=O)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1)c1ccccc1 CHEMBL3086031 IC50 440.0 nM
Cn1cc(-c2ccc(CN3CCC4(CC3)OC(c3cc(Cl)cc(Cl)c3)c3ccccc34)nc2)cn1 CHEMBL1951460 IC50 474.0 nM
C[C@@H](NC(=O)[C@@H]1CC[C@@H](N2CCOCC2)C[C@H]1c1ccc(Br)cc1)c1ccc(F)cc1 CHEMBL3086033 IC50 480.0 nM
Clc1cc2nc([C@@H]3CCCN3c3cc(N4CCCCC4)ncn3)[nH]c2cc1Cl CHEMBL1950896 IC50 509.0 nM
N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1CCC[C@H]1C(=O)c1nc2ccccc2[nH]1 CHEMBL1259235 IC50 518.0 nM
FC(F)(F)c1ccccc1C1CCN(c2cc(N3CCC[C@H]3c3nc4cc(Cl)c(Cl)cc4[nH]3)ncn2)CC1 CHEMBL1950897 IC50 537.0 nM
CC(=O)N1C[C@H](c2[nH]c(-c3ccccc3)nc2-c2ccccn2)CC[C@H]1c1ccccc1 CHEMBL3677676 IC50 554.0 nM
CCCCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)N1CCC[C@H]1C(=O)c1nc2ccccc2[nH]1 CHEMBL1256278 IC50 570.0 nM
Clc1cc2nc([C@@H]3CCCN3c3cc(N4CCN(Cc5ccccc5)CC4)ncn3)[nH]c2cc1Cl CHEMBL1950788 IC50 575.0 nM
Clc1ccc(-c2cc([C@@H]3CC[C@H](N4CCOCC4)C[C@H]3c3ccc(Br)cc3)[nH]n2)cc1 CHEMBL3237372 IC50 580.0 nM
Cc1cc(C2CCN(C(=O)[C@H]3C[C@](C)(N)C[C@@H]3c3ccc(F)cc3F)CC2)n(-c2ccc(F)c(Cl)c2)n1 CHEMBL2031592 IC50 635.0 nM
C=CCN1CC[C@]2(C)c3ccccc3CC1[C@@H]2C CHEMBL21326 IC50 760.0 nM
C=CCC(=O)OCCCC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)N1CCC[C@H]1C(=O)c1nc2ccccc2[nH]1 CHEMBL1256276 IC50 800.0 nM
Cc1nc(C2CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2ccccc2)n1 CHEMBL2022782 IC50 815.0 nM
Nc1cc(-c2ccc(-c3ccccc3)cc2)cnc1N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1950784 IC50 828.0 nM
Clc1cc2nc([C@@H]3CCCN3c3cc(NC4CCCCC4)ncn3)[nH]c2cc1Cl CHEMBL1950895 IC50 839.0 nM
CC(C)(C)OC(=O)N[C@@H](Cc1ccc(-c2ccc(C(=O)O)cc2)cc1)C(=O)N1CCC[C@H]1C(=O)c1nc2ccccc2[nH]1 CHEMBL1256280 IC50 849.0 nM
O=C(N[C@@H](COCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)c1nc2ccccc2[nH]1)OCC1c2ccccc2-c2ccccc21 CHEMBL1256273 IC50 850.0 nM
O=C([C@H]1CCN(CCc2ccc(Cl)cc2)C[C@@H]1c1ccc(F)cc1)N1CC(c2ccccc2)(c2ccccc2)C1 CHEMBL3237375 IC50 850.0 nM
Cc1cc(C2CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC2)n(-c2cc(Cl)cc(Cl)c2)n1 CHEMBL2022792 IC50 852.0 nM
Cc1ccccc1[C@@H]1C[C@H](N2CCOCC2)CC[C@H]1c1cc(C(c2ccccc2)c2ccccc2)n[nH]1 CHEMBL3237369 IC50 860.0 nM
Cc1ccccc1[C@@H]1C[C@H](N2CCOCC2)CC[C@H]1c1cc(-c2ccc(Cl)cc2)n[nH]1 CHEMBL3237370 IC50 940.0 nM
O=C([C@@H]1CCN(CCc2ccc(Cl)cc2)C[C@H]1c1ccc(F)cc1)N1CC(c2ccccc2)(c2ccccc2)C1 CHEMBL3237374 IC50 990.0 nM
C[C@H](NC(=O)CCc1cccc(-c2ccccc2)c1)c1nc2cc(Cl)c(Cl)cc2[nH]1 CHEMBL1950447 IC50 998.0 nM
c1ccc(CC2NCCc3ccccc32)cc1 CHEMBL21640 IC50 1000.0 nM
Fc1ccc([C@@H]2CNCC[C@H]2c2cc(-c3ccc(Cl)cc3)n[nH]2)cc1 CHEMBL3237388 IC50 1000.0 nM