CC1=C[C@@]23CC[C@@H]4[C@H]([C@H](C=C(CO)[C@@H](O)[C@]2(O)[C@H]1OC(=O)C1(C)CCCCC1)C3=O)C4(C)C CHEMBL3926213 EC50 0.1 nM
CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H]([C@@H](C)O)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1cccc(O)c1 CHEMBL2148106 Ki 0.17 nM
CC(C)[C@H]1C(=O)N[C@H](CO)Cc2cc(NC(=O)CCCCCCCCCCCCC(=O)Nc3ccc4c(c3)N(C)[C@@H](C(C)C)C(=O)N[C@H](CO)C4)ccc2N1C CHEMBL337834 Kd 0.19 nM
Cc1cccc2c(C3=C(c4nc(N5CCN(C)CC5)nc5ccccc45)C(=O)NC3=O)c[nH]c12 CHEMBL2151411 IC50 0.2 nM
CC1=CC23C(=O)[C@@H](C=C(CO)[C@@H](O)[C@@H]2[C@H]1OC(=O)C1(C)CCCCC1)[C@H]1[C@@H](C[C@H]3C)C1(C)C CHEMBL4113544 EC50 0.2 nM
CCCCCCCCc1ccc2c3c(c[nH]c13)C[C@@H](CO)NC(=O)[C@H](C(C)C)N2C CHEMBL285801 Ki 0.4 nM
CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H]([C@@H](C)O)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1cc(O)ccc1Br CHEMBL1256416 Ki 0.45 nM
CN(C)Cc1ccc2ccc(Cl)c(C3=C(c4cn(C)c5ccccc45)C(=O)NC3=O)c2c1 CHEMBL4077967 Ki 0.5 nM
O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c1nc(N2CCNCC2)nc2ccccc12 CHEMBL1996510 IC50 0.6 nM
CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccccc3n2)CC1 CHEMBL565612 IC50 0.64 nM
CN(C)Cc1ccc2ccc(Cl)c(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c2c1 CHEMBL4102228 IC50 0.7 nM
CC1=C[C@]23C(=O)[C@@H](C=C(CO)C[C@]2(O)[C@H]1OC(=O)C1(C)CCCCC1)[C@H]1[C@@H](C[C@H]3C)C1(C)C CHEMBL4115540 EC50 0.8 nM
CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3cc(F)ccc3n2)CC1 CHEMBL2153750 IC50 1.2 nM
CCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@@H](C=C(CO)C[C@]3(O)C(=O)C(C)=C[C@@H]23)[C@@H]2C(C)(C)[C@]12OC(=O)CCC CHEMBL27768 Kd 1.3 nM
Cn1cc(C2=C(c3nc(N4CCNCC4)nc4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL2151415 IC50 1.4 nM
NC[C@H]1Cc2c(C3=C(Nc4ccccc4)C(=O)NC3=O)c3ccccc3n2C1 CHEMBL2236794 IC50 1.4 nM
CNCc1ccc2ccc(Cl)c(C3=C(c4cn(C)c5ccccc45)C(=O)NC3=O)c2c1 CHEMBL4072879 IC50 1.4 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 1.44 nM
C[C@@H]1[C@@H]([C@@H](C)CCCc2cccc(O)c2)O[C@@]23C[C@@H]1OC(=O)C[C@H]([C@@H](C)O)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C CHEMBL2418196 Ki 1.5 nM
CN(C)CCCn1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL7463 IC50 1.6 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)[C@@H](C)CN1C1CCOCC1 CHEMBL3662851 Ki 1.7 nM
CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@@H](C=C(CO)C[C@]3(O)C(=O)C(C)=C[C@@H]23)[C@@H]2C(C)(C)[C@]12OC(C)=O CHEMBL279115 Ki 1.8 nM
CN1CCN(c2cc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccccc3c2)CC1 CHEMBL568580 IC50 1.8 nM
O=C(N[C@@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL60254 Kd 1.8 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)[C@@H](C)CN1CC1CCOCC1 CHEMBL3662848 Ki 1.9 nM
N[C@@H]1C[C@@H](NC(=O)c2ccc(O)cc2)[C@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)C1 CHEMBL432168 IC50 2.0 nM
N[C@@H]1C[C@H](NC(=O)c2ccc(O)cc2)[C@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)C1 CHEMBL417051 IC50 2.0 nM
N=C(N)SCCCn1cc(C2=C(Nc3ccccc3)C(=O)NC2=O)c2ccccc21 CHEMBL540357 IC50 2.0 nM
Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCC#N)c4c21)CNC3=O CHEMBL302449 IC50 2.0 nM
CN1CCN(c2cc3ccccc3c(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)n2)CC1 CHEMBL2153748 IC50 2.0 nM
CN(C)C[C@H]1CCn2c(c(C3=C(Nc4ccccc4)C(=O)NC3=O)c3ccccc32)C1 CHEMBL2236799 IC50 2.0 nM
Cn1cc(C2=C(c3c(Cl)ccc4ccc(CN5CCC5)cc34)C(=O)NC2=O)c2ccccc21 CHEMBL4089217 IC50 2.0 nM
CN(C)CCOc1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c2ccccc2c1 CHEMBL565632 IC50 2.1 nM
CNC[C@H]1Cc2c(C3=C(Nc4ccccc4)C(=O)NC3=O)c3ccccc3n2C1 CHEMBL2236809 IC50 2.2 nM
CCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@H]3CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCC CHEMBL265998 Ki 2.23 nM
CCNC[C@H]1Cc2c(C3=C(Nc4ccccc4)C(=O)NC3=O)c3ccccc3n2C1 CHEMBL2236793 IC50 2.4 nM
CC(C)NCc1ccc2ccc(Cl)c(C3=C(c4cn(C)c5ccccc45)C(=O)NC3=O)c2c1 CHEMBL4083319 IC50 2.9 nM
O=C(N[C@@H]1C[C@H](CO)C[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL75661 IC50 3.0 nM
O=C(OC1CCCC1Cc1ccc(O)cc1)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1 CHEMBL295806 IC50 3.0 nM
N=C(N)SCCCn1c(-c2cc3ccccc3s2)c(C2=CC(=O)NC2=O)c2ccccc21 CHEMBL350335 IC50 3.0 nM
O=C(N[C@H]1C[C@H](CO)C[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL306427 IC50 3.0 nM
C[C@H]1CN(C)C2(CCCC2)CN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C CHEMBL3658623 Ki 3.05 nM
COCCNCc1ccc2ccc(Cl)c(C3=C(c4cn(C)c5ccccc45)C(=O)NC3=O)c2c1 CHEMBL4101316 IC50 3.1 nM
Cn1cc(C2=C(c3c(Cl)ccc4ccc(CN)cc34)C(=O)NC2=O)c2ccccc21 CHEMBL4089665 IC50 3.3 nM
CN(C)Cc1ccc2c(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c(Cl)ccc2c1 CHEMBL4085837 IC50 3.4 nM
Cc1cccc2nc(N3CCN(C)CC3)nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c12 CHEMBL2153749 IC50 3.8 nM
NC[C@H]1C[C@@H](NC(=O)c2ccc(O)cc2)[C@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)C1 CHEMBL307708 IC50 4.0 nM
NC[C@H]1C[C@H](NC(=O)c2ccc(O)cc2)[C@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)C1 CHEMBL421866 IC50 4.0 nM
CN(C)CCCn1nc(C2=C(c3cn(-c4cnc5ccccc5c4)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL359486 IC50 4.0 nM
CN(C)C[C@H]1Cc2c(C3=C(Nc4ccccc4)C(=O)NC3=O)c3ccccc3n2C1 CHEMBL2236805 IC50 4.0 nM
O=C1NC(=O)C(c2c3n(c4ccccc24)C[C@@H](CO)C3)=C1Nc1ccccc1 CHEMBL2236804 IC50 4.0 nM
CN(C)C[C@H]1CCc2c(C3=C(Nc4ccccc4)C(=O)NC3=O)c3ccccc3n2C1 CHEMBL2236802 IC50 4.0 nM
CC(C)=C1CC(CO)(COC(=O)c2ccc(C#Cc3ccc(C)cc3)cc2)OC1=O CHEMBL522428 Ki 4.1 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4ccc(C(F)(F)F)cn4)n[nH]c3C2(C)C)[C@@H](C)CN1CC1CCOCC1 CHEMBL3667491 Ki 4.17 nM
CN(C)C[C@@H]1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1 CHEMBL432130 IC50 4.7 nM
CN(C)C[C@@H]1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1 CHEMBL91829 IC50 4.7 nM
CCN1CCC(n2cc(C3=C(c4cn(C)c5ccccc45)C(=O)NC3=O)c3ccccc32)CC1 CHEMBL54382 IC50 5.0 nM
NC[C@@H]1C[C@@H](NC(=O)c2ccc(O)cc2)[C@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)C1 CHEMBL308263 IC50 5.0 nM
CNC[C@@H]1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1 CHEMBL311543 IC50 5.0 nM
NC[C@@H]1C[C@H](NC(=O)c2ccc(O)cc2)[C@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)C1 CHEMBL67290 IC50 5.0 nM
CN(C)CCCn1nc(C2=C(c3cn(-c4ccc5ccccc5c4)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL368895 IC50 5.0 nM
O=C1NC(=O)C(c2cn(CCCn3ccnc3)c3ccccc23)=C1Nc1ccccc1 CHEMBL366266 IC50 5.0 nM
CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccc(F)cc3n2)CC1 CHEMBL2153755 IC50 5.0 nM
CCN(C)C[C@H]1Cc2c(C3=C(Nc4ccccc4)C(=O)NC3=O)c3ccccc3n2C1 CHEMBL2236807 IC50 5.0 nM
CN1CCN(c2nc(C3=C(c4cn(C)c5ccccc45)C(=O)NC3=O)c3ccccc3n2)CC1 CHEMBL2151412 IC50 5.1 nM
CN1CCN(c2cc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccccc3n2)CC1 CHEMBL2153747 IC50 5.2 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cc4ccccc4cn3)n[nH]c2C1(C)C CHEMBL3662882 Ki 5.51 nM
O=C1NC(=O)C2=C1c1cn(c3ccccc13)CCOCCOCCOCCn1cc2c2ccccc21 CHEMBL340259 IC50 6.0 nM
CN1CCN(c2nc(C3=C(c4c[nH]c5c(Cl)cccc45)C(=O)NC3=O)c3ccccc3n2)CC1 CHEMBL2151410 IC50 6.0 nM
CN(C)C[C@@H]1CCc2c(C3=C(Nc4ccccc4)C(=O)NC3=O)c3ccccc3n2C1 CHEMBL2236803 IC50 6.0 nM
O=C1NC(=O)C(c2c3n(c4ccccc24)CC[C@H](CO)C3)=C1Nc1ccccc1 CHEMBL2236798 IC50 6.0 nM
CC1=C[C@]23C(=O)[C@@H](C=C(CO)C[C@@H]2[C@H]1OC(=O)C1(C)CCCCC1)[C@H]1[C@@H](C[C@H]3C)C1(C)C CHEMBL4111556 EC50 6.0 nM
Cn1cc(C2=C(c3cn(C4CCN(Cc5ccccn5)CC4)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL300138 IC50 6.0 nM
CC(C)[C@H]1C(=O)N[C@H](CO)Cc2c[nH]c3cccc(c23)N1C CHEMBL27266 Ki 6.1 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccc4cnccc4n3)n[nH]c2C1(C)C CHEMBL3662883 Ki 6.17 nM
N#CCCn1c2ccccc2c2c3c(c4c5ccccc5[nH]c4c21)C(=O)NC3 CHEMBL292746 INH 6.2 nM
CN1CCN(c2nc(C3=C(c4c[nH]c5ccc(Cl)cc45)C(=O)NC3=O)c3ccccc3n2)CC1 CHEMBL2151408 IC50 6.5 nM
CN(C)Cc1ccc2c(C3=C(c4cn(C)c5ccccc45)C(=O)NC3=O)c(Cl)ccc2c1 CHEMBL4064291 IC50 6.8 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cc(C4CC4)n[nH]3)n[nH]c2C1(C)C CHEMBL3662884 Ki 6.81 nM
O=C(OC[C@@H](Cc1ccc(O)cc1)NS(=O)(=O)c1ccccc1)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1 CHEMBL345767 IC50 7.0 nM
CN(C)CCCn1nc(C2=C(c3cn(-c4cccnc4)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL368416 IC50 7.0 nM
CN1CCN(c2nc(C3=C(c4c[nH]c5cc(Cl)ccc45)C(=O)NC3=O)c3ccccc3n2)CC1 CHEMBL2151409 IC50 7.7 nM
CC(C)n1cc(C2=C(c3nc(N4CCN(C)CC4)nc4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL2151413 IC50 7.8 nM
CC(=O)NC[C@H]1Cc2c(C3=C(Nc4ccccc4)C(=O)NC3=O)c3ccccc3n2C1 CHEMBL2236795 IC50 7.9 nM
CN(C)C[C@@H]1Cc2c(C3=C(Nc4ccccc4)C(=O)NC3=O)c3ccccc3n2C1 CHEMBL2236797 IC50 8.0 nM
O=C1NC(=O)C(c2c3n(c4ccccc24)C[C@@H](CN2CCCC2)C3)=C1Nc1ccccc1 CHEMBL2236808 IC50 8.0 nM
C[C@H]1CN(C)C2(CCC2)CN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C CHEMBL3662839 Ki 8.58 nM
CN1CCOCCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCN(C)CC1 CHEMBL106384 IC50 9.0 nM
CCN1CCOCCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCOCC1 CHEMBL103055 IC50 9.0 nM
CCN1C[C@H](C)N(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)C[C@H]1C CHEMBL3662805 Ki 9.11 nM
CCCN1C[C@H](C)N(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)C[C@H]1CCO CHEMBL3662794 Ki 9.53 nM
CCCCCCn1cc2c3c(cccc31)N(C)[C@@H](C(C)C)C(=O)N[C@H](CO)C2 CHEMBL399981 Ki 9.8 nM
CN1CCC(n2cc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccccc32)CC1 CHEMBL52654 IC50 10.0 nM
Cn1cc(C2=C(c3cn(C4CCN(CC5CC5)CC4)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL55394 IC50 10.0 nM
CN1CCC(n2cc(C3=C(c4cn(C)c5ccccc45)C(=O)NC3=O)c3ccccc32)CC1 CHEMBL53596 IC50 10.0 nM
O=C(N[C@@H]1CNC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL59828 IC50 10.0 nM
O=C(N[C@@H]1CC(O)C[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL306580 IC50 10.0 nM
O=C(OC1CNCC1Cc1ccc(O)cc1)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1 CHEMBL300422 IC50 10.0 nM
O=C(N[C@@H]1CNCC1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL177635 IC50 10.0 nM
O=C(N[C@@H]1CNCCCC1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL311399 IC50 10.0 nM
O=C(NC1CNCC1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL265559 IC50 10.0 nM
O=C(NC1CNCCCC1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL49354 IC50 10.0 nM
O=C(N[C@H]1C[C@@H](O)C[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL1794808 IC50 10.0 nM
CN(C)CCCn1nc(C2=C(c3cn(-c4cccs4)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL178945 IC50 10.0 nM
CN(C)CCCn1cc(C2=C(Nc3cccc(Cl)c3)C(=O)NC2=O)c2ccccc21 CHEMBL364337 IC50 10.0 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3nc(Cl)c(Cl)s3)n[nH]c2C1(C)C CHEMBL3662786 Ki 10.4 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cc(C(C)(C)C)nn3C)n[nH]c2C1(C)C CHEMBL3662888 Ki 10.6 nM
C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3ccc(F)cc3)n[nH]c2C1(C)C CHEMBL3929905 Ki 11.2 nM
C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3ccc(Cl)cn3)n[nH]c2C1(C)C CHEMBL3969799 Ki 11.9 nM
CN(C)CCCn1cc(C2=C(Nc3ccccc3)C(=O)NC2=O)c2ccccc21 CHEMBL365656 IC50 12.0 nM
C[C@H]1[C@@H]2C[C@@]3(O[C@H](CCC3(C)C)CC(=O)O[C@@H](CO)CC(=O)O2)O[C@@H]1CCCCc1cccc(O)c1 CHEMBL2148108 Ki 12.0 nM
Cc1ccc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H](C)N(C4CCOCC4)C[C@@H]2C)C3(C)C)nc1 CHEMBL3662945 Ki 12.2 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cnc4ccccc4n3)n[nH]c2C1(C)C CHEMBL3662885 Ki 12.5 nM
C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3ccc(F)cn3)n[nH]c2C1(C)C CHEMBL3960180 Ki 12.8 nM
Cc1nc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2CCN(CC4CCOCC4)C[C@@H]2C)C3(C)C)cs1 CHEMBL3965116 Ki 12.8 nM
C[C@H]1CN2CCC[C@H]2CC1C(=O)N1Cc2c(NC(=O)c3csc(Br)n3)n[nH]c2C1(C)C CHEMBL3662813 Ki 12.9 nM
CN(C)CCCn1nc(C2=C(c3cn(-c4ccccc4)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL366668 IC50 13.0 nM
C[C@H]1CN(CC2CC2)CCN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C CHEMBL3901906 Ki 13.3 nM
CCCCN1CCN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)[C@@H](C)C1 CHEMBL3923758 Ki 13.3 nM
CCCCCCCC(=O)O[C@H]1/C(=C/C(=O)OC)CC2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H]3CCC[C@H](C[C@@H]4CCO[C@H](/C=C/C(C)(C)[C@]1(O)O2)O4)O3 CHEMBL46252 Ki 13.4 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccc(Cl)c(Cl)c3)n[nH]c2C1(C)C CHEMBL3662750 Ki 13.9 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cc4cccn4cn3)n[nH]c2C1(C)C CHEMBL3662788 Ki 13.9 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)[C@@H](C)CN1C CHEMBL3662823 Ki 13.9 nM
O=C1NC(=O)C(c2c3n(c4ccccc24)C[C@H](CO)C3)=C1Nc1ccccc1 CHEMBL2236796 IC50 14.0 nM
CC(C)[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C CHEMBL3662810 Ki 14.1 nM
C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3cn(C4CCC4)cn3)n[nH]c2C1(C)C CHEMBL3921008 Ki 14.1 nM
CCCN1CCN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)[C@@H](C)C1 CHEMBL3917094 Ki 14.6 nM
CCC1NC(C(=O)Nc2n[nH]c3c2CN(C(=O)N2CCN(CC4CCOCC4)C[C@@H]2C)C3(C)C)=CO1 CHEMBL3961038 Ki 14.9 nM
CN(C)CCCn1nc(C2=C(c3cn(-c4cncc5ccccc45)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL359808 IC50 15.0 nM
CN(C)CCCCn1cc(C2=C(Nc3ccccc3)C(=O)NC2=O)c2ccccc21 CHEMBL184548 IC50 15.0 nM
Cc1cccc(NC2=C(c3cn(CCCN(C)C)c4ccccc34)C(=O)NC2=O)c1 CHEMBL369114 IC50 15.0 nM
C[C@@H]1CC(C)(C)[C@@]23C[C@@H](C[C@@H](CCCCc4cccc(O)c4)O2)OC(=O)C[C@H](CO)OC(=O)C[C@@H]1O3 CHEMBL2148107 Ki 15.0 nM
CC(C)[C@@](C)(O)[C@@H]1CN(c2nc(-c3n[nH]c4ncccc34)c(F)cc2Cl)CCN1 CHEMBL2326002 Ki 15.0 nM
Cc1cccc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2CCN(CC4CCOCC4)C[C@@H]2C)C3(C)C)n1 CHEMBL3947241 Ki 15.0 nM
CN1CCN(Cc2ccc3ccc(Cl)c(C4=C(c5cn(C)c6ccccc56)C(=O)NC4=O)c3c2)CC1 CHEMBL4068028 IC50 15.0 nM
CC(C)=C1CC(CO)(COC(=O)CCCOc2ccc(C#Cc3ccc(C)cc3)cc2)OC1=O CHEMBL489520 Ki 15.2 nM
CC[C@H](C)[C@H]1CN2C[C@H](O)C[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C CHEMBL3662795 Ki 15.2 nM
C=CCN1C[C@H](C)N(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)C[C@H]1C CHEMBL3662799 Ki 15.7 nM
C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3coc(C4CC4)n3)n[nH]c2C1(C)C CHEMBL3934515 Ki 15.7 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccc4c(c3)CCO4)n[nH]c2C1(C)C CHEMBL3639616 Ki 15.9 nM
O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c1c[nH]c2ccccc12 CHEMBL266487 IC50 16.0 nM
CC1(C)c2[nH]nc(NC(=O)c3ccc4ccccc4n3)c2CN1C(=O)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1 CHEMBL3662729 Ki 16.1 nM
COc1cccc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H]4CCCN4C[C@@H]2Cc2ccccc2)C3(C)C)c1 CHEMBL3662732 Ki 16.1 nM
COc1nccc(-c2c(-c3ccc(F)cc3)ncn2C2CCNCC2)n1 CHEMBL95692 IC50 17.0 nM
O=C(NC1CNC[C@@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL422056 IC50 17.0 nM
CC(C)N1CCOCCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCOCC1 CHEMBL421217 IC50 17.0 nM
O=C1NC(=O)C(c2cn(CCCN3CCCCC3)c3ccccc23)=C1Nc1ccccc1 CHEMBL187235 IC50 17.0 nM
O=C1NC(=O)C(c2c3n(c4ccccc24)CC[C@@H](CO)C3)=C1Nc1ccccc1 CHEMBL2236800 IC50 17.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 17.0 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cccc(C#N)c3)n[nH]c2C1(C)C CHEMBL3662773 Ki 17.1 nM
CCCCCCCCC#Cc1ccc2c(c1)C[C@@H](CO)NC(=O)[C@H](C(C)C)N2C CHEMBL6453 Ki 17.4 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)[C@@H](C)CN1CCC1CCOCC1 CHEMBL3662850 Ki 17.6 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccc4ccccc4n3)n[nH]c2C1(C)C CHEMBL3662798 Ki 17.8 nM
O=C1NC(=O)C(c2nn(CCCN3CCOCC3)c3ccccc23)=C1c1cn(-c2ccc3ccccc3c2)c2ccccc12 CHEMBL367106 IC50 18.0 nM
O=C1NC(=O)C(c2cn(CCCN3CCCC3)c3ccccc23)=C1Nc1ccccc1 CHEMBL184042 IC50 18.0 nM
CC1(C)c2[nH]nc(NC(=O)c3ccccn3)c2CN1C(=O)N1C[C@@H]2CCCN2C[C@@H]1CC1CCCCC1 CHEMBL3662769 Ki 18.1 nM
C[C@H]1CN(C)C(C)(C)CN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C CHEMBL3662835 Ki 18.1 nM
CC(C)N1CCC(n2cc(C3=C(c4cn(C)c5ccccc45)C(=O)NC3=O)c3ccccc32)CC1 CHEMBL301860 IC50 19.0 nM
CCN1CCOCCOCCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CC1 CHEMBL103506 IC50 19.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OC[C@H]3CCCNC3)c21 CHEMBL494089 IC50 19.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL574737 Kd apparent 19.0 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4cc(C5CC5)n[nH]4)n[nH]c3C2(C)C)[C@@H](C)CN1CC1CCOCC1 CHEMBL3662908 Ki 19.4 nM
C[C@H]1CN(C)CCN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C CHEMBL3914339 Ki 19.5 nM
COCCCN1CCN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)[C@@H](C)C1 CHEMBL3931196 Ki 19.5 nM
Cc1nc(C)c(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H](C)N(CC4CCOCC4)C[C@@H]2C)C3(C)C)o1 CHEMBL3662911 Ki 19.7 nM
CC1CN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)C(C)CN1CCCO CHEMBL3662809 Ki 19.9 nM
CC(C)(C)C(=O)OCOC(=O)c1cccc(O)c1C(=O)c1c(O)cc(C(=O)O[C@@H]2CNC[C@H]2NC(=O)c2ccc(O)cc2)cc1O CHEMBL304175 IC50 20.0 nM
CC(=O)OCOC(=O)c1cccc(O)c1C(=O)c1c(O)cc(C(=O)O[C@@H]2CNC[C@H]2NC(=O)c2ccc(O)cc2)cc1O CHEMBL67528 IC50 20.0 nM
O=C(N[C@@H]1C[C@@H](CO)C[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL75004 IC50 20.0 nM
O=C(N[C@@H]1C[C@@H](O)C[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL309034 IC50 20.0 nM
O=C(OC1CCCC1Oc1ccc(O)cc1)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1 CHEMBL48988 IC50 20.0 nM
Cc1ccc(S(=O)(=O)N2CCC[C@@H](OC(=O)c3cc(O)c(C(=O)c4c(O)cccc4C(=O)O)c(O)c3)[C@H](NC(=O)c3ccc(O)cc3)C2)cc1 CHEMBL146846 IC50 20.0 nM
O=C(OC[C@H](Cc1ccc(O)cc1)NS(=O)(=O)c1ccccc1)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1 CHEMBL151822 IC50 20.0 nM
O=C(N[C@H]1C[C@@H](CO)C[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL431955 IC50 20.0 nM
O=C(N[C@H]1C[C@H](O)C[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL67716 IC50 20.0 nM
CCn1nc(C)cc1C(=O)Nc1n[nH]c2c1CN(C(=O)N1C[C@@H](C)N(CC3CCOCC3)C[C@@H]1C)C2(C)C CHEMBL3662905 Ki 20.0 nM
Cc1noc(C)c1CC(=O)Nc1n[nH]c2c1CN(C(=O)N1C[C@@H](C)N(CC3CCOCC3)C[C@@H]1C)C2(C)C CHEMBL3667490 Ki 20.0 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccc(Br)cn3)n[nH]c2C1(C)C CHEMBL3662801 Ki 20.3 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccc(F)cn3)n[nH]c2C1(C)C CHEMBL3662802 Ki 20.3 nM
Cc1cc(C)nc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H]4CCCN4C[C@@H]2C)C3(C)C)c1 CHEMBL3662764 Ki 20.9 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cccc(Cl)c3)n[nH]c2C1(C)C CHEMBL3662745 Ki 21.3 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cc(Cl)ccn3)n[nH]c2C1(C)C CHEMBL3662780 Ki 21.3 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4ccc(F)cn4)n[nH]c3C2(C)C)[C@@H](C)CN1CCCO CHEMBL3662867 Ki 21.7 nM
Cc1ccnc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2CCN(CC4CCOCC4)C[C@@H]2C)C3(C)C)c1 CHEMBL3933521 Ki 21.7 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccc(F)c(Cl)c3)n[nH]c2C1(C)C CHEMBL3662748 Ki 21.9 nM
Cn1cc(C2=C(c3cn(C4CCN(Cc5ccccc5)C4)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL291975 IC50 22.0 nM
Cc1[nH]c2ccccc2c1C1=C(c2nc(N3CCN(C)CC3)nc3ccccc23)C(=O)NC1=O CHEMBL2151414 IC50 22.0 nM
CCN1C[C@H](C)N(C(=O)N2Cc3c(NC(=O)c4ccc(F)cn4)n[nH]c3C2(C)C)C[C@@H]1C CHEMBL3662832 Ki 22.2 nM
CCc1nc(C)c(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H](C)N(CC4CCOCC4)C[C@@H]2C)C3(C)C)o1 CHEMBL3662893 Ki 22.4 nM
Cc1nc(C)c(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H](C)N(CC4CCOCC4)C[C@@H]2C)C3(C)C)s1 CHEMBL3662901 Ki 22.6 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)C1Cc2c(NC(=O)c3cc(Cl)cc(Cl)c3)n[nH]c2C1(C)C CHEMBL3662744 Ki 22.9 nM
C=Cn1cc(C2=C(c3nn(CCCN(C)C)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL368193 IC50 23.0 nM
CN1CCN(CCCn2cc(C3=C(Nc4ccccc4)C(=O)NC3=O)c3ccccc32)CC1 CHEMBL184146 IC50 23.0 nM
CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3cc(Cl)ccc3n2)CC1 CHEMBL2153751 IC50 23.0 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)[C@@H](C)CN1CCCC#N CHEMBL3662846 Ki 23.6 nM
CCc1ccc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H]4CCCN4C[C@@H]2C)C3(C)C)cc1 CHEMBL3662774 Ki 23.8 nM
CCn1cnc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2CCN(CC4CCOCC4)C[C@@H]2C)C3(C)C)c1 CHEMBL3986299 Ki 23.8 nM
CN1CCN(C[C@@H]2CCn3cc(c4ccccc43)C3=C(C(=O)NC3=O)c3cn(c4ccccc34)CCO2)CC1 CHEMBL91959 IC50 24.0 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4ccncn4)n[nH]c3C2(C)C)[C@@H](C)CN1C1CCOCC1 CHEMBL3662944 Ki 24.0 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccc(Cl)cn3)n[nH]c2C1(C)C CHEMBL3662779 Ki 24.3 nM
C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3ccc(C#N)cc3)n[nH]c2C1(C)C CHEMBL3987088 Ki 24.3 nM
COCCCN1C[C@H](C)N(C(=O)N2Cc3c(NC(=O)c4ccc(F)cn4)n[nH]c3C2(C)C)C[C@H]1C CHEMBL3662868 Ki 24.5 nM
Cc1nc(C)c(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H](C)N(CCCO)C[C@@H]2C)C3(C)C)o1 CHEMBL3662865 Ki 24.9 nM
CN(C)C[C@@H]1CCn2c(c(C3=C(Nc4ccccc4)C(=O)NC3=O)c3ccccc32)C1 CHEMBL2236801 IC50 25.0 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4coc(C5CC5)n4)n[nH]c3C2(C)C)[C@@H](C)CN1C CHEMBL3662879 Ki 25.0 nM
C[C@H](CCO)N1C[C@H](C)N(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)C[C@H]1C CHEMBL3662859 Ki 25.1 nM
C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3cccc(C#N)c3)n[nH]c2C1(C)C CHEMBL3967714 Ki 25.6 nM
CCc1nc(C)c(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H](C)N(C)C[C@@H]2C)C3(C)C)o1 CHEMBL3662877 Ki 25.7 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4ccn(C)n4)n[nH]c3C2(C)C)[C@@H](C)CN1CC1CCOCC1 CHEMBL3662907 Ki 25.8 nM
O=C(NC1CN2CCC(CC2)C1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL306884 IC50 26.0 nM
O=C(N[C@@H]1CN2CCC(CC2)[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL78129 IC50 26.0 nM
Cc1ccc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2CCN(CC4CCOCC4)C[C@@H]2C)C3(C)C)nc1 CHEMBL3960003 Ki 26.4 nM
CCc1cc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H](C)N(CC4CCOCC4)C[C@@H]2C)C3(C)C)no1 CHEMBL3662910 Ki 26.5 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4cc(C5CC5)on4)n[nH]c3C2(C)C)[C@@H](C)CN1C CHEMBL3662845 Ki 26.8 nM
CCn1ccc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2CCN(CC4CCOCC4)C[C@@H]2C)C3(C)C)n1 CHEMBL3912065 Ki 26.9 nM
CN1CCOCCN(C)CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CC1 CHEMBL105477 IC50 27.0 nM
CN1CCN(C)CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCN(C)CC1 CHEMBL103628 IC50 27.0 nM
O=C1NC(=O)C2=C1c1cn(c3ccccc13)CCO[C@H](CO)CCn1cc2c2ccccc21 CHEMBL292495 IC50 28.0 nM
CN(C)CCn1cc(C2=C(Nc3ccccc3)C(=O)NC2=O)c2ccccc21 CHEMBL184649 IC50 28.0 nM
CCN1C[C@H](C)N(C(=O)N2Cc3c(NC(=O)c4cnccn4)n[nH]c3C2(C)C)C[C@H]1C CHEMBL3662873 Ki 28.6 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4ccc(C#N)cn4)n[nH]c3C2(C)C)[C@@H](C)CN1C CHEMBL3667493 Ki 28.7 nM
CC1(C)c2[nH]nc(NC(=O)c3ccc4ccncc4n3)c2CN1C(=O)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1 CHEMBL3662739 Ki 28.8 nM
CC1(C)c2[nH]nc(NC(=O)c3cccc(Cl)c3)c2CN1C(=O)N1CCN2CCCC2C1 CHEMBL3662737 Ki 28.9 nM
Cc1nc(C)c(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H]4CCCN4C[C@@H]2C)C3(C)C)o1 CHEMBL3662889 Ki 28.9 nM
CN(C)CCCn1nc(C2=C(c3cn(-c4cccc5ccccc45)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL360304 IC50 29.0 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(CC(=O)c3ccccn3)n[nH]c2C1(C)C CHEMBL3658622 Ki 29.2 nM
C[C@H]1CN2CCC[C@@]2(C)CN1C(=O)N1Cc2c(NC(=O)c3ccc(F)cn3)n[nH]c2C1(C)C CHEMBL3662843 Ki 29.3 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4cc(C5CC5)on4)n[nH]c3C2(C)C)[C@@H](C)CN1CC1CCOCC1 CHEMBL3662902 Ki 29.8 nM
Cn1cc(C2=C(c3cn(C4CCNCC4)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL55788 IC50 30.0 nM
Cn1cc(C2=C(c3cn(C4CCN(Cc5ccccc5)CC4)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL300549 IC50 30.0 nM
O=C(N[C@@H]1CCC[C@H]1COC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL60455 IC50 30.0 nM
O=C(NC1C2CCC(C2)C1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL305667 IC50 30.0 nM
O=C(NC1C2CC(C3CCCC32)C1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL72480 IC50 30.0 nM
O=C(NC1CNCCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL89648 IC50 30.0 nM
O=C(N[C@@H]1C2CCC(C2)[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL80525 IC50 30.0 nM
O=C(N[C@@H]1C2CC(C3CCCC32)[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL263910 IC50 30.0 nM
CC(CCc1ccc(O)cc1)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1 CHEMBL148745 IC50 30.0 nM
O=C(OCC(Cc1ccc(O)cc1)NS(=O)(=O)c1ccccc1)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1 CHEMBL358264 IC50 30.0 nM
O=C1NC(=O)C(c2cn(CCCO)c3ccccc23)=C1Nc1ccccc1 CHEMBL185221 IC50 30.0 nM
C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3ccccc3)n[nH]c2C1(C)C CHEMBL3943487 Ki 30.1 nM
COc1ccc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H]4CCCN4C[C@@H]2Cc2ccccc2)C3(C)C)cc1 CHEMBL3662733 Ki 30.2 nM
Cc1nc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H]4CCCN4C[C@@H]2C)C3(C)C)cs1 CHEMBL3662887 Ki 31.3 nM
Cc1nc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H](C)N(CC4CCOCC4)C[C@@H]2C)C3(C)C)c(C)o1 CHEMBL3662914 Ki 31.3 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccc(C(F)(F)F)cn3)n[nH]c2C1(C)C CHEMBL3662836 Ki 31.5 nM
O=C(N[C@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL307747 IC50 32.0 nM
CCN(CC)C[C@H]1Cc2c(C3=C(Nc4ccccc4)C(=O)NC3=O)c3ccccc3n2C1 CHEMBL2236806 IC50 32.0 nM
CCc1cc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H](C)N(CC4CCOCC4)C[C@@H]2C)C3(C)C)on1 CHEMBL3662909 Ki 32.1 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cc(N(C)C)ccn3)n[nH]c2C1(C)C CHEMBL3662797 Ki 32.3 nM
COc1ccc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H]4CCCN4C[C@@H]2C)C3(C)C)cc1 CHEMBL3662754 Ki 32.7 nM
NC[C@@H]1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1 CHEMBL316239 IC50 33.0 nM
Cc1cc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H](C)N(CC4CCOCC4)C[C@@H]2C)C3(C)C)n(C)n1 CHEMBL3662903 Ki 33.0 nM
CCc1nc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H](C)N(CC4CCOCC4)C[C@@H]2C)C3(C)C)cs1 CHEMBL3662916 Ki 33.3 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccccc3)n[nH]c2C1(C)C CHEMBL3662741 Ki 35.1 nM
Cc1nc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H](C)N(C)C[C@@H]2C)C3(C)C)cs1 CHEMBL3662875 Ki 35.1 nM
Cc1cc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H]4CCCN4C[C@@H]2C)C3(C)C)nc(Cl)n1 CHEMBL3662771 Ki 35.3 nM
CN1CCN(c2cccc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c2)CC1 CHEMBL585500 IC50 36.0 nM
C[C@@H]1CC(=O)Nc2ncnc(N3CCC(c4nc(-c5ccc(F)c(C(F)(F)F)c5)cn4CCN4CCCC4)CC3)c21 CHEMBL4128457 IC50 36.0 nM
CC1CN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)C(C)CN1 CHEMBL3662760 Ki 36.2 nM
CCCCCCCC(=O)O[C@H]1/C(=C/C(=O)OC)CC2C[C@H]([C@@H](C)O)OC(=O)C[C@H](O)CCO[C@H](C(C)(C)C)C[C@@H]3CCO[C@H](/C=C/C(C)(C)[C@]1(O)O2)O3 CHEMBL45053 Ki 36.4 nM
CC1(C)c2[nH]nc(NC(=O)c3cccc(Oc4ccccc4)c3)c2CN1C(=O)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1 CHEMBL3658624 Ki 36.8 nM
CN(C)CCCn1nc(C2=C(c3cn(-c4csc5ccccc45)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL426587 IC50 37.0 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)[C@@H](C)CN1CC1(C)COC1 CHEMBL3662858 Ki 37.0 nM
CC[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)[C@@H](C)CN1C CHEMBL3662837 Ki 37.2 nM
CCc1cc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H](C)N(CCCOC)C[C@@H]2C)C3(C)C)n(C)n1 CHEMBL3662896 Ki 37.3 nM
COc1cccc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H]4CCCN4C[C@@H]2C)C3(C)C)c1 CHEMBL3662753 Ki 37.5 nM
O=C1NC(=O)C2=C1c1cn(c3ccccc13)CCO[C@H](CN1CCOCC1)CCn1cc2c2ccccc21 CHEMBL315357 IC50 38.0 nM
Cc1cc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H](C)N(CC4CCOCC4)C[C@@H]2C)C3(C)C)on1 CHEMBL3662912 Ki 38.1 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)[C@@H](C)CN1CCCCC#N CHEMBL3662849 Ki 38.3 nM
C[C@H]1CN(CCO)CCN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C CHEMBL3984847 Ki 38.8 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4ccc(F)cn4)n[nH]c3C2(C)C)[C@@H](C)CN1CCO CHEMBL3662866 Ki 38.8 nM
CCCN1CCN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)CC)[C@@H](C)C1 CHEMBL3933186 Ki 39.5 nM
O=C(N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL52529 IC50 40.0 nM
O=C(NC1CCC[C@@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL71331 IC50 40.0 nM
COC(=O)c1cccc(O)c1C(=O)c1c(O)cc(C(=O)O[C@@H]2CCC[C@H]2NC(=O)c2ccc(O)cc2)cc1O CHEMBL66923 IC50 40.0 nM
O=C1NC(=O)C2=C1c1cn(c3ccccc13)CCOCCN(CCO)CCOCCn1cc2c2ccccc21 CHEMBL321529 IC50 40.0 nM
O=C(NC1CCCC1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL48636 IC50 40.0 nM
O=C(N[C@@H]1CCCC1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL427118 IC50 40.0 nM
CN1CCOCCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCOCC1 CHEMBL106061 IC50 41.0 nM
CN(C)CCCCCn1cc(C2=C(Nc3ccccc3)C(=O)NC2=O)c2ccccc21 CHEMBL184647 IC50 41.0 nM
CC(=O)N(C)Cc1ccc2ccc(Cl)c(C3=C(c4cn(C)c5ccccc45)C(=O)NC3=O)c2c1 CHEMBL4100747 IC50 41.0 nM
Cc1cc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H](C)N(CC4CCOCC4)C[C@@H]2C)C3(C)C)no1 CHEMBL3662904 Ki 41.1 nM
C[C@H]1CN(C)[C@H](CCO)CN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C CHEMBL3662855 Ki 42.0 nM
Cc1ccc2ccc(CN)cc2c1C1=C(c2cn(C)c3ccccc23)C(=O)NC1=O CHEMBL4078759 IC50 42.0 nM
CC1(C)c2[nH]nc(NC(=O)c3cccc(Cl)n3)c2CN1C(=O)N1CCN2CCCC2C1 CHEMBL3662738 Ki 42.9 nM
Cc1ccc2ccc(CN)cc2c1C1=C(c2c[nH]c3ccccc23)C(=O)NC1=O CHEMBL4099609 IC50 43.0 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)[C@@H](C)CN1[C@@H](C)CCO CHEMBL3662860 Ki 43.3 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)[C@@H](C)CN1CCCF CHEMBL3662847 Ki 43.4 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cscn3)n[nH]c2C1(C)C CHEMBL3662758 Ki 43.5 nM
O=C1NC(=O)C2=C1c1cn(c3ccccc13)CCO[C@H](CN1CCCC1)CCn1cc2c2ccccc21 CHEMBL419866 IC50 44.0 nM
O=C1NC(=O)C2=C1c1cn(c3ccccc13)CCO[C@H](CNS(=O)(=O)c1ccccc1)CCn1cc2c2ccccc21 CHEMBL315389 IC50 44.0 nM
O=C1NC(=O)C(c2nn(CCCN3CCCC3)c3ccccc23)=C1c1cn(-c2ccc3ccccc3c2)c2ccccc12 CHEMBL367107 IC50 44.0 nM
CN1CCCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCOCCOCC1 CHEMBL321315 IC50 45.0 nM
Cc1ocnc1C(=O)Nc1n[nH]c2c1CN(C(=O)N1C[C@@H](C)N(C)C[C@@H]1C)C2(C)C CHEMBL3639617 Ki 45.1 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccc(OC(F)(F)F)cc3)n[nH]c2C1(C)C CHEMBL3662755 Ki 45.4 nM
CCCN1C[C@H](C)N(C(=O)N2Cc3c(NC(=O)c4ccc(F)cc4F)n[nH]c3C2(C)C)C[C@H]1CCO CHEMBL3662812 Ki 45.9 nM
O=C1NC(=O)C2=C1c1cn(c3ccccc13)CCOCCOCCOCCn1cc2c2cccnc21 CHEMBL340935 IC50 46.0 nM
CC[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C CHEMBL3662782 Ki 46.2 nM
Cc1ncoc1C(=O)Nc1n[nH]c2c1CN(C(=O)N1C[C@@H](C)N(C)C[C@@H]1C)C2(C)C CHEMBL3662876 Ki 46.5 nM
COc1cccc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2CCN(CC4CCOCC4)C[C@@H]2C)C3(C)C)n1 CHEMBL3914445 Ki 46.7 nM
CN(C)CCCn1cc(C2=C(c3csc4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL566424 IC50 47.0 nM
Cc1nonc1C(=O)Nc1n[nH]c2c1CN(C(=O)N1C[C@@H](C)N(CC3CCOCC3)C[C@@H]1C)C2(C)C CHEMBL3662913 Ki 47.3 nM
COc1cccc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H]4CCCN4C[C@@H]2C)C3(C)C)c1 CHEMBL3939506 Ki 47.4 nM
C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3cncn3C)n[nH]c2C1(C)C CHEMBL3971197 Ki 47.9 nM
CN1CCN(c2nc(C3=C(c4c[nH]c5cccc(Cl)c45)C(=O)NC3=O)c3ccccc3n2)CC1 CHEMBL2151407 IC50 48.0 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)[C@@H](C)CN1Cc1cocn1 CHEMBL3662853 Ki 48.3 nM
C[C@@H](CO)CN1CCN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)[C@@H](C)C1 CHEMBL4114009 Ki 49.6 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3nc4ccccc4s3)n[nH]c2C1(C)C CHEMBL3662767 Ki 49.9 nM
CC[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cccc(Cl)c3)n[nH]c2C1(C)C CHEMBL3662783 Ki 49.9 nM
O=C(N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2NS(=O)(=O)C(F)(F)F)c(O)c1)c1ccc(O)cc1 CHEMBL52869 IC50 50.0 nM
O=C(NC1CCCC1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2NS(=O)(=O)C(F)(F)F)c(O)c1)c1ccc(O)cc1 CHEMBL312846 IC50 50.0 nM
O=C(N[C@@H]1c2ccccc2C[C@@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL367127 IC50 50.0 nM
Cc1nc(C)c(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H](C)N(C)C[C@@H]2C)C3(C)C)o1 CHEMBL3662874 Ki 50.3 nM
C[C@H](CO)CN1CCN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)[C@@H](C)C1 CHEMBL3945458 Ki 50.4 nM
CC1(C)c2[nH]nc(NC(=O)c3cccc(F)c3F)c2CN1C(=O)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1 CHEMBL3662735 Ki 50.8 nM
Cc1cc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H]4CCCN4C[C@@H]2C)C3(C)C)ccc1F CHEMBL3662775 Ki 50.8 nM
CC(C)[C@H]1CN(C)C(C)CN1C(=O)N1Cc2c(NC(=O)c3ccc(Cl)cn3)n[nH]c2C1(C)C CHEMBL4111227 Ki 51.2 nM
CCc1ocnc1C(=O)Nc1n[nH]c2c1CN(C(=O)N1C[C@@H](C)N(CC3CCOCC3)C[C@@H]1C)C2(C)C CHEMBL3662906 Ki 52.1 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4cnccn4)n[nH]c3C2(C)C)[C@@H](C)CN1CC1CCOCC1 CHEMBL3667488 Ki 52.7 nM
CC1c2[nH]nc(NC(=O)c3ccccc3F)c2CN1C(=O)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1 CHEMBL3949655 Ki 53.2 nM
Cc1cccc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H]4CCCN4C[C@@H]2C)C3(C)C)c1 CHEMBL3662777 Ki 54.5 nM
CCCCN1CCN(C(=O)N2Cc3c(NC(=O)c4ccc(F)cc4F)n[nH]c3C2(C)C)[C@@H](C)C1 CHEMBL3985036 Ki 54.9 nM
CC1(C)c2[nH]nc(NC(=O)c3cccc(Oc4ccccc4)c3)c2CN1C(=O)N1CCNCC1c1ccccc1 CHEMBL3658631 Ki 55.9 nM
Cc1cc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H]4CCCN4C[C@@H]2C)C3(C)C)nc(C)n1 CHEMBL3662787 Ki 56.9 nM
COCCN1C[C@H](C)N(C(=O)N2Cc3c(NC(=O)c4ccc(F)cn4)n[nH]c3C2(C)C)C[C@H]1C CHEMBL3662869 Ki 56.9 nM
CC(C)=C1CC(CO)(COC(=O)CCOc2ccc(C#Cc3ccc(C)cc3)cc2)OC1=O CHEMBL492118 Ki 57.0 nM
CC1c2[nH]nc(NC(=O)c3ccccn3)c2CN1C(=O)N1C[C@@H]2CCCN2C[C@@H]1C CHEMBL3934903 Ki 57.6 nM
CN(C)CCOc1cccc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c1 CHEMBL566853 IC50 58.0 nM
CCCCCCCCCCc1ccc2c(c1)C[C@@H](CO)NC(=O)[C@H](C(C)C)N2C CHEMBL28205 Ki 58.2 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cc(C4CC4)on3)n[nH]c2C1(C)C CHEMBL3662890 Ki 58.6 nM
CCCc1cc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H](C)N(CC4CCOCC4)C[C@@H]2C)C3(C)C)no1 CHEMBL3662915 Ki 59.4 nM
CC(C)C1C[C@@H](NC(=O)c2ccc(O)cc2)[C@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)C1 CHEMBL76920 IC50 60.0 nM
CN(C)CCCn1cc(C2=C(c3cccc4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL584483 IC50 60.0 nM
CN(Cc1ccc2ccc(Cl)c(C3=C(c4cn(C)c5ccccc45)C(=O)NC3=O)c2c1)C1CC1 CHEMBL4073977 IC50 60.0 nM
CCc1cc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H]4CCCN4C[C@@H]2C)C3(C)C)no1 CHEMBL3662880 Ki 61.6 nM
CCC1(CC)c2[nH]nc(NC(=O)c3ccccn3)c2CN1C(=O)N1C[C@@H]2CCCN2C[C@@H]1C CHEMBL3662838 Ki 61.9 nM
CN1CCN(CCCn2nc(C3=C(c4cn(-c5ccc6ccccc6c5)c5ccccc45)C(=O)NC3=O)c3ccccc32)CC1 CHEMBL175845 IC50 62.0 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4cn(C)cn4)n[nH]c3C2(C)C)[C@@H](C)CN1CC1CCOCC1 CHEMBL3662892 Ki 62.4 nM
C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3cn(C)cn3)n[nH]c2C1(C)C CHEMBL3948813 Ki 62.4 nM
COCCN1C[C@H](C)N(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)C[C@H]1C CHEMBL3662803 Ki 63.6 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 65.0 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cccc(F)c3F)n[nH]c2C1(C)C CHEMBL3662776 Ki 65.4 nM
COc1ccc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H]4CCCN4C[C@@H]2C)C3(C)C)nc1 CHEMBL3662761 Ki 65.5 nM
CCc1ccnc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H]4CCCN4C[C@@H]2C)C3(C)C)c1 CHEMBL3662766 Ki 66.3 nM
CCc1ocnc1C(=O)Nc1n[nH]c2c1CN(C(=O)N1C[C@@H](C)N(C)C[C@@H]1C)C2(C)C CHEMBL3662878 Ki 66.4 nM
COCCCN1C[C@H](C)N(C(=O)N2Cc3c(NC(=O)Cc4c(C)noc4C)n[nH]c3C2(C)C)C[C@H]1C CHEMBL3662899 Ki 67.1 nM
Cc1ccccc1C(=O)Nc1n[nH]c2c1CN(C(=O)N1CCN(CC3CCOCC3)C[C@@H]1C)C2(C)C CHEMBL3985199 Ki 67.1 nM
CN1CCC(F)(C(=O)N2Cc3c(NC(=O)c4ccc(Cl)c(Cl)c4)n[nH]c3C2(C)C)CC1 CHEMBL3662872 Ki 67.4 nM
CC[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccccc3)n[nH]c2C1(C)C CHEMBL3662781 Ki 67.8 nM
Cc1cc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H]4CCCN4C[C@@H]2C)C3(C)C)n(C)n1 CHEMBL3662756 Ki 67.9 nM
COc1cc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H]4CCCN4C[C@@H]2C)C3(C)C)ccc1Cl CHEMBL3662762 Ki 68.8 nM
C[C@H]1CN(CC2CC2)CCN1C(=O)N1Cc2c(NC(=O)c3ccc(F)cc3F)n[nH]c2C1(C)C CHEMBL3896223 Ki 68.9 nM
CC(C)N1CCN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)[C@@H](C)C1 CHEMBL3929842 Ki 69.2 nM
Cn1ccnc1C(=O)Nc1n[nH]c2c1CN(C(=O)N1C[C@@H]3CCCN3C[C@@H]1Cc1ccccc1)C2(C)C CHEMBL3662740 Ki 69.3 nM
C[C@@]1(OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)CCCNC[C@H]1NC(=O)c1ccc(O)cc1 CHEMBL433101 IC50 70.0 nM
COCCCN1C[C@H](C)N(C(=O)N2Cc3c(NC(=O)c4oc(C)cc4C)n[nH]c3C2(C)C)C[C@H]1C CHEMBL3662897 Ki 71.8 nM
Cc1cnc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H]4CCCN4C[C@@H]2C)C3(C)C)cn1 CHEMBL3662881 Ki 72.9 nM
CC1(C)c2[nH]nc(NC(=O)c3ccc4ccccc4n3)c2CN1C(=O)N1CCN2CCCC2C1 CHEMBL3662727 Ki 73.9 nM
CCC1(C)c2[nH]nc(NC(=O)c3ncc(F)cc3F)c2CN1C(=O)C1C[C@@H]2CCCN2C[C@@H]1C CHEMBL3662796 Ki 74.1 nM
C[C@H]1CN(C2CCC2)CCN1C(=O)N1Cc2c(NC(=O)c3ccc(F)cc3F)n[nH]c2C1(C)C CHEMBL3924237 Ki 74.2 nM
CN1CCOCCOCCN(C)CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CC1 CHEMBL105620 IC50 75.0 nM
NCc1ccc2cccc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c2c1 CHEMBL4061321 IC50 75.0 nM
CC[C@H]1CN2CCC[C@@]2(C)CN1C(=O)N1Cc2c(NC(=O)c3ccc(F)cn3)n[nH]c2C1(C)C CHEMBL3662844 Ki 75.2 nM
CC1(C)c2n[nH]c(NC(=O)c3ccccn3)c2CN1C(=O)C1(F)CCN(C2CCC2)CC1 CHEMBL3662870 Ki 75.3 nM
CC(C)=C1CC(CO)(COC(=O)COc2ccc(C#Cc3ccc(C)cc3)cc2)OC1=O CHEMBL523155 Ki 76.0 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C23CC3)[C@@H](C)CN1CC1CCOCC1 CHEMBL3662857 Ki 76.2 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)C[C@H](C)N1 CHEMBL3662743 Ki 77.6 nM
C[C@H]1CN2CCC[C@@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C CHEMBL3662789 Ki 77.8 nM
CN1CCN(C(=O)N2Cc3c(NC(=O)c4ccc5ccccc5n4)n[nH]c3C2(C)C)[C@@H](Cc2ccccc2)C1 CHEMBL3658629 Ki 78.1 nM
COCCCN1C[C@H](C)N(C(=O)N2Cc3c(NC(=O)c4cc(C)nc(C)n4)n[nH]c3C2(C)C)C[C@H]1C CHEMBL3662894 Ki 78.4 nM
CCC1CN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)CCN1C CHEMBL3662791 Ki 79.6 nM
Cn1cc(C2=C(c3cn(C4CCN(C(=O)OC(C)(C)C)CC4)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL293805 IC50 80.0 nM
CC1(C)C2CCC1(C)C(OC(=O)c1cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c1)C2NC(=O)c1ccc(O)cc1 CHEMBL306170 IC50 80.0 nM
CC1(C)C2CCC1(C)[C@@H](OC(=O)c1cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c1)[C@@H]2NC(=O)c1ccc(O)cc1 CHEMBL309078 IC50 80.0 nM
C[C@H]1CN(CC2CCCC2)CCN1C(=O)N1Cc2c(NC(=O)c3ccc(F)cc3F)n[nH]c2C1(C)C CHEMBL3918822 Ki 81.3 nM
CC1(C)CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C CHEMBL3662793 Ki 81.8 nM
CCc1ccc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H]4CCCN4C[C@@H]2C)C3(C)C)nc1 CHEMBL3662763 Ki 82.1 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cc(Cl)ccc3F)n[nH]c2C1(C)C CHEMBL3662747 Ki 82.7 nM
C[C@H]1CN(C)CCN1C(=O)N1Cc2c(NC(=O)c3ccc(F)cc3F)n[nH]c2C1(C)C CHEMBL3920342 Ki 83.1 nM
CCc1nc(C)c(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H](C)N(CCCOC)C[C@@H]2C)C3(C)C)o1 CHEMBL3662898 Ki 83.6 nM
C[C@H]1CN2C[C@H]3CC3[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C CHEMBL3662814 Ki 83.7 nM
C[C@@H]1C(=O)NN=C2COc3cc(-c4ccccc4)c(NC4CNC4)cc3N21 CHEMBL3356472 IC50 87.0 nM
C[C@H]1CN(C)C(C)(C)CN1C(=O)N1Cc2c(NC(=O)c3ccc(F)cc3F)n[nH]c2C1(C)C CHEMBL3662824 Ki 87.1 nM
CCCN1CCN(C(=O)N2Cc3c(NC(=O)c4ccc(F)cc4F)n[nH]c3C2(C)C)[C@@H](C)C1 CHEMBL3964302 Ki 87.3 nM
CC1(C)CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cccc(Cl)c3)n[nH]c2C1(C)C CHEMBL3662770 Ki 87.4 nM
CC(C)[C@H]1C(=O)N[C@H](CO)Cc2cn3ncc4ccc(c2c43)N1C CHEMBL271403 Ki 88.0 nM
CC1(C)CC[C@@H]2CC(=O)O[C@@H](CO)CC(=O)O[C@@H]3C[C@@H](CCCCc4cccc(O)c4)O[C@@]1(C3)O2 CHEMBL1258348 Ki 89.0 nM
CC1(C)c2[nH]nc(NC(=O)c3ccccn3)c2CN1C(=O)C1(F)CCN(C2CCOCC2)CC1 CHEMBL3662871 Ki 89.8 nM
COC(=O)c1cccc(O)c1C(=O)c1c(O)cc(C(=O)OC2CCCC2Cc2ccc(O)cc2)cc1O CHEMBL48665 IC50 90.0 nM
CC(C)[C@H]1CN(C)C(C)(C)CN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C CHEMBL3662840 Ki 90.1 nM
CC1(C)c2[nH]nc(NC(=O)c3ccccc3Cl)c2CN1C(=O)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1 CHEMBL3662734 Ki 91.4 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccccc3F)n[nH]c2C1(C)C CHEMBL3662746 Ki 92.4 nM
Cn1cc(C2=C(c3cccc4ccc(CN)cc34)C(=O)NC2=O)c2ccccc21 CHEMBL4083182 IC50 93.0 nM
CC[C@H]1CN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)[C@@H](C)CN1C CHEMBL3662831 Ki 93.9 nM
COc1cc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H]4CCCN4C[C@@H]2C)C3(C)C)nc(OC)n1 CHEMBL3662772 Ki 94.5 nM
COCCCN1C[C@H](C)N(C(=O)N2Cc3c(NC(=O)c4ocnc4C)n[nH]c3C2(C)C)C[C@H]1C CHEMBL3662900 Ki 95.6 nM
CCC[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccccc3)n[nH]c2C1(C)C CHEMBL3662742 Ki 96.1 nM
C[C@H]1CN(CC2(O)CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C CHEMBL3932340 Ki 96.1 nM
CC(C)C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccc4ccccc4n3)n[nH]c2C1(C)C CHEMBL3662728 Ki 103.0 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cccc(OC(F)(F)F)c3)n[nH]c2C1(C)C CHEMBL3662759 Ki 104.0 nM
CC[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccccc3F)n[nH]c2C1(C)C CHEMBL3662784 Ki 105.0 nM
CC[C@H]1CN2CCC[C@@H]2CN1C(=O)N1Cc2c(CC(=O)c3ccccn3)n[nH]c2C1(C)C CHEMBL3662800 Ki 107.0 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)[C@@H](C)CN1CCOCCO CHEMBL3662861 Ki 108.0 nM
C[C@H]1CN2C[C@@H](F)C[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C CHEMBL3662815 Ki 109.0 nM
CS(=O)(=O)Nc1cccc(O)c1C(=O)c1c(O)cc(C(=O)OC2CCCC2NC(=O)c2ccc(O)cc2)cc1O CHEMBL88749 IC50 110.0 nM
CCN1CCOCCN(CC)CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCOCC1 CHEMBL103421 IC50 110.0 nM
COC(=O)c1cccc(O)c1C(=O)c1c(O)cc(C(=O)OC2CNCC2Cc2ccc(O)cc2)cc1O CHEMBL48546 IC50 110.0 nM
CC1(C)c2[nH]nc(NC(=O)c3ccccc3)c2CN1C(=O)N1CCN2CCCC2C1 CHEMBL3662731 Ki 113.0 nM
CC[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccc(F)cc3)n[nH]c2C1(C)C CHEMBL3662785 Ki 115.0 nM
C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3cocn3)n[nH]c2C1(C)C CHEMBL3906555 Ki 117.0 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccnn3C)n[nH]c2C1(C)C CHEMBL3662886 Ki 118.0 nM
CN1C[C@@H]2C[C@H]1CN2c1ccc(-c2ccnc3c(-c4cccc(O)c4)c(-c4ccncc4)nn23)cc1 CHEMBL1087650 IC50 119.0 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccc(C#N)cc3F)n[nH]c2C1(C)C CHEMBL3662778 Ki 122.0 nM
CN1CCN(C(=O)N2Cc3c(NC(=O)c4cc5ccccc5o4)n[nH]c3C2(C)C)[C@@H](Cc2ccccc2)C1 CHEMBL3658628 Ki 124.0 nM
CC(C)[C@H]1C(=O)N[C@H](CO)Cc2cn3nc(C(F)(F)F)c4ccc(c2c43)N1C CHEMBL261387 Ki 127.0 nM
CC[C@H](C)[C@H]1CN2CCC[C@@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C CHEMBL3662792 Ki 129.0 nM
COCCCN1CCN(C(=O)N2Cc3c(NC(=O)c4ccc(F)cc4F)n[nH]c3C2(C)C)[C@@H](C)C1 CHEMBL3940515 Ki 131.0 nM
C[C@@H]1CN(C(=O)N2Cc3c(NC(=O)c4ncccn4)n[nH]c3C2(C)C)[C@@H](C)CN1CC1CCOCC1 CHEMBL3667489 Ki 133.0 nM
Cn1cc(C2=C(c3cccc4cc(CN)ccc34)C(=O)NC2=O)c2ccccc21 CHEMBL4072709 IC50 133.0 nM
CC1CN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)CCN1CC1CC1 CHEMBL3662833 Ki 134.0 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cncs3)n[nH]c2C1(C)C CHEMBL3662757 Ki 135.0 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3c(F)ccc(F)c3F)n[nH]c2C1(C)C CHEMBL3662891 Ki 135.0 nM
CC1(C)c2[nH]nc(NC(=O)c3cccs3)c2CN1C(=O)N1CCN2CCCC2C1 CHEMBL3662730 Ki 136.0 nM
N=C(N)NCCC[C@@H](NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)CCCCCCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)C(=O)O CHEMBL610876 IC50 140.0 nM
CC1(C)CC[C@@H]2CC(=O)O[C@@H](CO)CC(=O)O[C@@H]3C[C@@H](CCCCc4ccccc4)O[C@@]1(C3)O2 CHEMBL1258117 Ki 140.0 nM
Cc1ccc2nc(N3CCN(C)CC3)nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c2c1 CHEMBL2153752 IC50 140.0 nM
CN1CCN(C(=O)N2Cc3c(n[nH]c3NC(=O)c3cc4ccccc4s3)C2(C)C)[C@@H](Cc2ccccc2)C1 CHEMBL3658625 Ki 146.0 nM
CC(C)[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccc(F)cc3F)n[nH]c2C1(C)C CHEMBL3662811 Ki 148.0 nM
Cc1cc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H]4CCCN4C[C@@H]2C)C3(C)C)nn1C CHEMBL3662765 Ki 149.0 nM
CCN1CCN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)[C@@H](C)C1 CHEMBL3915993 Ki 149.0 nM
CS(=O)(=O)Nc1cccc(O)c1C(=O)c1c(O)cc(C(=O)O[C@@H]2CCC[C@H]2NC(=O)c2ccc(O)cc2)cc1O CHEMBL294166 IC50 150.0 nM
Cc1cccc(NC2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c1 CHEMBL185573 IC50 151.0 nM
C[C@H]1CN(C)[C@@H](CCO)CN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C CHEMBL3662856 Ki 152.0 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3c(F)cccc3C(F)(F)F)n[nH]c2C1(C)C CHEMBL3662751 Ki 155.0 nM
CCN1CCN(C(=O)N2Cc3c(NC(=O)c4ccccn4)n[nH]c3C2(C)C)CC1C CHEMBL3662834 Ki 156.0 nM
CN1CCN(C(=O)N2Cc3c(NC(=O)c4cccc(Oc5ccccc5)c4)n[nH]c3C2(C)C)C(c2ccccc2)C1 CHEMBL3658630 Ki 159.0 nM
CC1(C)c2[nH]nc(NC(=O)c3ccccn3)c2CN1C(=O)N1C[C@@H]2CCCN2C[C@@H]1CO CHEMBL3662790 Ki 165.0 nM
O=C(N[C@@H]1c2ccccc2CC1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL177308 IC50 170.0 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cc(C(F)(F)F)ccc3F)n[nH]c2C1(C)C CHEMBL3662749 Ki 176.0 nM
CC(C)c1csc(C(=O)Nc2n[nH]c3c2CN(C(=O)N2C[C@@H]4CCCN4C[C@@H]2C)C3(C)C)n1 CHEMBL3662768 Ki 177.0 nM
CO[C@@H]1CN2C[C@H](C)N(C(=O)N3Cc4c(NC(=O)c5ccccn5)n[nH]c4C3(C)C)C[C@@H]2C1C CHEMBL3941144 Ki 177.0 nM
CC(C)[C@H]1/C(S)=N/[C@H](CO)Cc2c[nH]c3cccc(c23)N1C CHEMBL63262 Ki 179.5 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3c(F)cccc3Cl)n[nH]c2C1(C)C CHEMBL3662752 Ki 181.0 nM
C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)C3CCCCO3)n[nH]c2C1(C)C CHEMBL3662822 Ki 186.0 nM
CN1CCN(C(=O)N2Cc3c(NC(=O)c4cccs4)n[nH]c3C2(C)C)[C@@H](Cc2ccccc2)C1 CHEMBL3658627 Ki 187.0 nM
CC1c2[nH]nc(NC(=O)c3ccccc3)c2CN1C(=O)N1CCN(C)C[C@@H]1Cc1ccccc1 CHEMBL3901971 Ki 189.0 nM
O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1Nc1cccc(Cl)c1 CHEMBL187325 IC50 198.0 nM
CN1CCN(C)CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CC1 CHEMBL319265 IC50 200.0 nM
O=C(OCCCc1ccc(O)cc1)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1 CHEMBL151800 IC50 210.0 nM
O=C(N[C@@H]1CCCCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL304549 IC50 220.0 nM
O=C(N[C@@H]1CNC[C@H]1NC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL59677 IC50 220.0 nM
O=C(N[C@H]1CCCCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL302998 IC50 220.0 nM
CS(=O)(=O)NC(COC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)Cc1ccc(O)cc1 CHEMBL149604 IC50 220.0 nM
O=C1NC(=O)C(c2cn(-c3cccnc3)c3ccccc23)=C1c1[nH]nc2ccccc12 CHEMBL175956 IC50 220.0 nM
O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1Nc1ccccc1 CHEMBL183310 IC50 223.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 233.0 nM
CN(C)CCCn1cc(C2=C(c3cccc4ccccc34)C(=O)NC2=O)c2cccnc21 CHEMBL326688 IC50 240.0 nM
O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1Nc1cccc(F)c1 CHEMBL186981 IC50 249.0 nM
O=C(NC1CCCC1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2-c2nn[nH]n2)c(O)c1)c1ccc(O)cc1 CHEMBL89384 IC50 260.0 nM
O=C(NC1CNCC1OC(=O)c1cc(O)c(C(=O)c2c(O)ccc3c2CCCC3)c(O)c1)c1ccc(O)cc1 CHEMBL91126 IC50 260.0 nM
O=C(N[C@@H]1CC(C(=O)C(F)(F)F)C[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL262980 IC50 260.0 nM
CC(C)C[C@H]1CN(c2ccc(C(F)(F)F)c(C(=O)c3cccnc3N)n2)CCN1 CHEMBL2046643 Ki 260.0 nM
O=C1NC(=O)C(c2cn(CCCO)c3ncccc23)=C1c1cccc2ccccc12 CHEMBL430694 IC50 270.0 nM
O=C1NC(=O)C2=C1c1cn(c3ccccc13)CCCOC(CO)CCn1cc2c2ccccc21 CHEMBL294120 IC50 270.0 nM
N=C(N)NCCC[C@@H](NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)CCCCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)C(=O)O CHEMBL610874 IC50 270.0 nM
CCCCCCCC(=O)O[C@H]1/C(=C/C(=O)OC)CC2C[C@H]([C@@H](C)O)OC(=O)C[C@@H](O)C[C@@H]3CCC[C@H](C[C@@H]4CCO[C@H](/C=C/C(C)(C)[C@]1(O)O2)O4)O3 CHEMBL46053 Ki 280.0 nM
O=C(N[C@@H]1CCC[C@H]1OCc1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL294303 IC50 290.0 nM
O=C(N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2-c2nn[nH]n2)c(O)c1)c1ccc(O)cc1 CHEMBL298872 IC50 290.0 nM
O=C(NC1CCCC1OCc1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL89833 IC50 290.0 nM
COC(=O)c1cccc(O)c1C(=O)c1c(O)cc(C(=O)O[C@@H]2CNC[C@H]2NC(=O)c2ccc(O)cc2)cc1O CHEMBL304626 IC50 290.0 nM
CC(=O)C1=C(O)C=C2Oc3c(C(N)=O)c(O)cc(O)c3[C@]2(C)C1=O CHEMBL475816 IC50 300.0 nM
CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccc(Cl)cc3n2)CC1 CHEMBL2153756 IC50 304.0 nM
O=C1NC(=O)C2=C1c1cn(c3ccccc13)CCO[C@H](CNCc1ccccc1)CCn1cc2c2ccccc21 CHEMBL328229 IC50 310.0 nM
N=C(N)NCCC[C@@H](NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)CCCCCCCCCCNC(=O)[C@H]1OC(n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)C(=O)O CHEMBL611121 IC50 320.0 nM
O=C(O)COc1cccc(O)c1C(=O)c1c(O)cc(C(=O)OC2CCCC2NC(=O)c2ccc(O)cc2)cc1O CHEMBL89210 IC50 330.0 nM
CS(=O)(=O)C1C[C@@H](NC(=O)c2ccc(O)cc2)[C@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)C1 CHEMBL306623 IC50 330.0 nM
COC(=O)c1cccc(O)c1C(=O)c1c(O)cc(C(=O)OC[C@@H](Cc2ccc(O)cc2)NS(=O)(=O)c2ccccc2)cc1O CHEMBL146847 IC50 340.0 nM
O=C(OCCCCc1ccc(O)cc1)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1 CHEMBL439996 IC50 370.0 nM
Cc1cc2c3c(c1)c(C1=C(c4cnc5ccccn45)C(=O)NC1=O)cn3CCN(C(=O)N1CCCCC1)C2 CHEMBL186290 IC50 370.0 nM
C[C@H](N)CNc1nc(-c2ccncc2)cc2cnccc12 CHEMBL2147537 IC50 378.0 nM
N#Cc1cnc(NCc2ccccc2OC(F)(F)F)nc1NC[C@]12C[C@@H]3C[C@H](C1)[C@@H](NCCO)[C@@H](C3)C2 CHEMBL4289707 IC50 410.0 nM
O=C1NC(=O)C(c2cnc3ccccn23)=C1c1cn2c3c(cc(F)cc13)CN(C(=O)N1CCCCC1)CC2 CHEMBL362558 IC50 420.0 nM
CC[C@@](C)(Nc1ccnc(-c2c[nH]c3ncccc23)n1)C(=O)NCC(F)(F)F CHEMBL3039513 Kd apparent 426.0 nM
CC(C)OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(C(=O)O[C@@H]2CCC[C@H]2NC(=O)c2ccc(O)cc2)cc1O CHEMBL431568 IC50 440.0 nM
CCCCCCn1cc2c3c(cccc31)N(C)[C@@H](C(C)C)C(=O)N[C@H](CO)CC2 CHEMBL401369 Ki 440.0 nM
COC(=O)c1cccc(O)c1C(=O)c1c(O)cc(C(=O)OCCCc2ccc(O)cc2)cc1O CHEMBL149313 IC50 460.0 nM
Cc1ccc(NC2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)cc1 CHEMBL186980 IC50 480.0 nM
O=C(N[C@H]1CNCCC[C@@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL77970 IC50 500.0 nM
CN(C)C(COC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)Cc1ccc(O)cc1 CHEMBL421790 IC50 500.0 nM
O=C(N[C@H]1CNCCCC1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 CHEMBL367488 IC50 500.0 nM
CO[C@@H]1[C@H](N(C)c2ncc(-c3ccccc3)o2)C[C@H]2C[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL5284949 IC50 500.0 nM
CO[C@@H]1[C@H](N(C)c2ncc(-c3c[nH]c4ccccc34)o2)C[C@H]2C[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL5288923 IC50 500.0 nM
Cc1cc2c(cc1NC1CNC1)N1C(=NNC(=O)[C@H]1C)CO2 CHEMBL3356470 IC50 520.0 nM
CCCCCCCCCCc1cccc2c1C[C@@H](CO)OC(=O)[C@H](C(C)C)N2C CHEMBL103091 Ki 539.0 nM
O=C1NC(=O)C(c2cnc3ccccn23)=C1c1cn2c3c(cccc13)CN(C(=O)N1CCCCC1)CC2 CHEMBL362588 IC50 560.0 nM
CCCCCCCCCCCC(=O)Oc1ccc2c(c1)[C@](C)(C(C)C)[C@H]1C(=O)N[C@H](CO)[C@@H]21 CHEMBL368720 Ki 593.0 nM
CCCCCCCCCCc1ccc2c(c1)N(C)[C@@H](C(C)C)C(=O)O[C@H](CO)C2 CHEMBL102858 Ki 610.0 nM
COCCCN1C[C@H](C)N(C(=O)N2Cc3c(NC(=O)c4cnccn4)n[nH]c3C2(C)C)C[C@H]1C CHEMBL3662895 Ki 625.0 nM
O=C(N[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1 CHEMBL59687 IC50 630.0 nM
c1cc(-c2cc3cnccc3c(N3CCCNCC3)n2)ccn1 CHEMBL2147542 IC50 661.0 nM
CNC(=O)C1C[C@@H](NC(=O)c2ccc(O)cc2)[C@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)C1 CHEMBL312067 IC50 680.0 nM
COc1cc(Nc2nc(N[C@H]3CCCC[C@H]3N)n3cnnc3c2C(N)=O)cc(OC)c1 CHEMBL475609 IC50 680.0 nM
Cc1c(Nc2c(C#N)cncc2/C=C/c2cccc(CN3CCN(C)CC3)n2)ccc2[nH]ccc12 CHEMBL1084411 IC50 700.0 nM
CCCCCCCCC#Cc1ccc2c(c1)[C@](C)(C(C)C)[C@H]1C(=O)N[C@H](CO)[C@@H]21 CHEMBL440201 Ki 701.0 nM
CC(=O)C1C[C@@H](NC(=O)c2ccc(O)cc2)[C@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)C1 CHEMBL441802 IC50 710.0 nM
O=C1NC(=O)C(c2cn(CCCO)c3ncccc23)=C1c1ccccc1Cl CHEMBL326971 IC50 730.0 nM
C=C[C@@]1(C)CC[C@](C)(C(C)C)c2cc3c4c(c[nH]c4c21)CC(=O)NC(=O)[C@H](C(C)C)N3C CHEMBL1807163 Ki 730.0 nM
COc1cccc(NC2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c1 CHEMBL186901 IC50 747.0 nM
NCCCNc1nc(-c2ccncc2)cc2cnccc12 CHEMBL2147544 IC50 779.0 nM
O=C(NC1CNCCC[C@H]1OC(=O)c1cc(O)c(C2OC(=O)c3cccc(O)c32)c(O)c1)c1ccc(O)cc1 CHEMBL86680 IC50 800.0 nM
CC(C)OC(=O)N1CCn2cc(C3=C(c4cnc5ccccn45)C(=O)NC3=O)c3cccc(c32)C1 CHEMBL363058 IC50 800.0 nM
Cc1c(Nc2c(C#N)cncc2-c2cc3cc(CN4CCN(C)CC4)ccc3o2)ccc2[nH]ccc12 CHEMBL571581 IC50 800.0 nM
COC(=O)C1C[C@@H](NC(=O)c2ccc(O)cc2)[C@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)C1 CHEMBL77399 IC50 810.0 nM
c1cc(-c2cc3cnccc3c(N3CCNCC3)n2)ccn1 CHEMBL1214932 IC50 823.0 nM
O=C(OCC(COc1ccc(O)cc1)NS(=O)(=O)c1ccccc1)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1 CHEMBL150264 IC50 830.0 nM
NCCNc1nc(-c2ccncc2)cc2cnccc12 CHEMBL1214929 IC50 859.0 nM
NC1CCCN(c2nc(-c3ccncc3)cc3cnccc23)C1 CHEMBL2147543 IC50 865.0 nM
COc1ccccc1C1=C(c2cn(CCCNS(N)(=O)=O)c3ncccc23)C(=O)NC1=O CHEMBL423323 IC50 890.0 nM
CN(C1=C(c2c[nH]c3ccccc23)C(=O)NC1=O)c1ccccc1 CHEMBL187024 IC50 939.0 nM
CC(C)(N)CNc1nc(-c2ccncc2)cc2cnccc12 CHEMBL2147538 IC50 942.0 nM
CC(C)(N)CNc1nc(-c2ccncc2F)cc2cnccc12 CHEMBL2147550 IC50 961.0 nM
CCOC(=O)c1cccc(O)c1C(=O)c1c(O)cc(C(=O)O[C@@H]2CNC[C@H]2NC(=O)c2ccc(O)cc2)cc1O CHEMBL307543 IC50 1000.0 nM
CN(C)C(=O)N1CCn2cc(C3=C(c4cnc5ccccn45)C(=O)NC3=O)c3cccc(c32)C1 CHEMBL362814 IC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM