Nc1ccc(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)c(F)c1 CHEMBL4635482 IC50 0.1 nM
c1ccc(-c2cc(N[C@H]3CCCNC3)c3ccncc3c2)cc1 CHEMBL4636488 IC50 0.2 nM
Nc1ccc(-c2cc(NC3CCCNC3)c3ccncc3c2)cc1 CHEMBL4646995 IC50 0.5 nM
Oc1ccc(-c2cc(NC3CCCNC3)c3ccncc3c2)cc1 CHEMBL4644939 IC50 0.6 nM
Nc1ccc(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)c(F)c1F CHEMBL4636337 IC50 0.8 nM
Nc1ccc(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)cn1 CHEMBL4632523 IC50 0.9 nM
CCOC(=O)c1c(-c2ccc(N(C)C)cc2)csc1N CHEMBL2393448 EC50 1.0 nM
CCOC(=O)c1c(-c2ccc(N)cc2)csc1N CHEMBL2393447 EC50 1.0 nM
COc1cccc(COC(=O)c2c(-c3ccc(OC)c(OC)c3)csc2N)c1 CHEMBL2393431 EC50 1.0 nM
Nc1ccc(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)c(F)n1 CHEMBL4643553 IC50 1.1 nM
Nc1ccc(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)cc1 CHEMBL4642166 IC50 1.4 nM
Nc1cc(F)c(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)cc1F CHEMBL4637452 IC50 1.4 nM
CCOC(=O)c1c(-c2ccc3c(c2)OCO3)csc1N CHEMBL2393450 EC50 2.0 nM
COc1ccc(-c2csc(N)c2C(=O)OCc2ccccc2)cc1OC CHEMBL2393427 EC50 2.0 nM
COc1cc(-c2ccc3c(-c4nc5c(N6CCN(C)CC6)cccc5[nH]4)n[nH]c3c2)ccc1O CHEMBL514197 IC50 2.26 nM
O=C(c1ccc(Nc2nccc(-c3cc4ccccc4s3)n2)cc1)N1CCC(N2CCCC2)CC1 CHEMBL200027 EC50 3.0 nM
COc1ccc(-c2csc(N)c2C(=O)OC(C)C)cc1OC CHEMBL2393423 EC50 3.0 nM
Nc1cc(F)c(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)cn1 CHEMBL4647780 IC50 3.4 nM
NCCNc1cc(-c2ccccc2)cc2cnccc12 CHEMBL4643470 IC50 4.1 nM
CN1CCN(c2cccc3nc(-c4n[nH]c5cc(-c6ccc(N)cc6)ccc45)[nH]c23)CC1 CHEMBL480391 IC50 5.18 nM
CN1CCN(c2cccc3[nH]c(-c4n[nH]c5cc(-c6ccc(O)cc6)ccc45)nc23)CC1 CHEMBL473631 IC50 5.6 nM
c1ccc(-c2cc(NC3CCCNC3)c3ccncc3c2)cc1 CHEMBL4641918 IC50 6.4 nM
c1ccc(-c2cc(N[C@H]3CCCCNC3)c3ccncc3c2)cc1 CHEMBL4632384 IC50 9.7 nM
CCOC(=O)c1c(-c2ccc(OC)cc2F)csc1N CHEMBL2393451 EC50 10.0 nM
COc1cc2c(cc1-n1cnc3ccc(-c4ccnc5[nH]ccc45)cc31)CNC2 CHEMBL4213984 IC50 10.0 nM
c1cc(-c2nc(N3CCNCC3)c3c4c(sc3n2)CCCC4)ccn1 CHEMBL3732444 IC50 12.0 nM
c1cc2cc(-c3cncc4ccc(O[C@H]5CCNC5)cc34)cnc2[nH]1 CHEMBL4644763 IC50 13.0 nM
CC(=O)Nc1ccc(-c2cc(NC3CCCNC3)c3ccncc3c2)cc1 CHEMBL4642061 IC50 13.0 nM
Fc1cccc(F)c1-c1cc(N[C@H]2CCCCNC2)c2ccncc2c1 CHEMBL4634517 IC50 15.2 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 19.95 nM
COc1cc(O)ccc1-c1ccc2c(-c3nc4c(N5CCN(C)CC5)cccc4[nH]3)n[nH]c2c1 CHEMBL474619 IC50 22.0 nM
COc1cc(N)ccc1-c1ccc2c(-c3nc4c(N5CCN(C)CC5)cccc4[nH]3)n[nH]c2c1 CHEMBL471790 IC50 23.3 nM
NC1CCC(Nc2nccc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1966628 pKi 25.12 nM
CCn1c(-c2nonc2N)nc2cnc(Oc3cccc(NC(=O)c4ccc(OCCN5CCOCC5)cc4)c3)cc21 CHEMBL220241 pKi 25.12 nM
Nc1ccc(-c2cncc3ccc(O[C@H]4CCNC4)cc23)cc1 CHEMBL4645728 IC50 33.0 nM
c1ccc(-c2cc(N[C@@H]3CCCNC3)c3ccncc3c2)cc1 CHEMBL4641607 IC50 35.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 39.4 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 40.0 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 50.12 nM
COc1cc(-c2ccc3c(-c4nc5c(N6CCN(C)CC6)cccc5[nH]4)n[nH]c3c2)ccc1N CHEMBL482368 IC50 51.3 nM
Oc1ccccc1-c1cc(NC2CCCNC2)c2ccncc2c1 CHEMBL4648006 IC50 54.0 nM
CN1CCN(c2cccc3[nH]c(-c4n[nH]c5cc(-c6ccc(N)c(F)c6)ccc45)nc23)CC1 CHEMBL519795 IC50 55.5 nM
CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccccc3n2)CC1 CHEMBL565612 pKi 63.1 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 79.43 nM
NCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL590109 pKi 79.43 nM
Nc1ccc(-c2cncc3ccc(OC4CCNCC4)cc23)cc1 CHEMBL4646074 IC50 109.0 nM
C=C(C)C(C)(C)C(C)CC[C@@H](C)[C@H]1CC[C@@]2(C)[C@@H]3C[C@H](OS(=O)(=O)[O-])[C@H]4[C@@H](O)[C@H](OS(=O)(=O)[O-])[C@@H](OS(=O)(=O)[O-])C[C@]4(C)C3=CC[C@]12C CHEMBL446072 IC50 110.0 nM
c1cc(-c2cncc3ccc(O[C@H]4CCNC4)cc23)cs1 CHEMBL4639268 IC50 141.0 nM
Oc1cccc(-c2cncc3ccc(O[C@H]4CCNC4)cc23)c1 CHEMBL4641149 IC50 142.0 nM
c1csc(-c2cncc3ccc(O[C@H]4CCNC4)cc23)c1 CHEMBL4633764 IC50 147.0 nM
Nc1ccccc1-c1cc(NC2CCCNC2)c2ccncc2c1 CHEMBL4645229 IC50 153.0 nM
NC(=O)Cn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL1985095 pKi 158.49 nM
NC(COc1cncc(-c2cc3ccncc3s2)c1)Cc1c[nH]c2ccccc12 CHEMBL1966524 pKi 158.49 nM
Nc1cccc(-c2cc(NC3CCCNC3)c3ccncc3c2)c1 CHEMBL4640042 IC50 162.0 nM
C[C@H](Nc1nc(Nc2cn(C)cn2)c2cc[nH]c2n1)c1ncc(F)cn1 CHEMBL3116050 IC50 200.0 nM
CN[C@H]1CC2OC([C@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(O)=NC4 CHEMBL3975634 IC50 204.2 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 251.19 nM
N[C@H](CNc1nc(-c2ccncc2)nc2sc3c(c12)CCCC3)Cc1ccccc1 CHEMBL3732675 IC50 270.0 nM
CN1CCN(c2cccc3[nH]c(-c4n[nH]c5cc(-c6ccc(CO)cc6)ccc45)nc23)CC1 CHEMBL474807 IC50 290.0 nM
CC(C)(C)C1=NN(c2cccc(Cl)c2)C(c2ccc(F)c(O)c2)C1 CHEMBL3323358 IC50 300.0 nM
Nc1ccc(-c2cncc3ccc(OC[C@@H]4CCCN4)cc23)cc1 CHEMBL4638383 IC50 321.0 nM
c1ccc2cc(-c3cncc4ccc(O[C@H]5CCNC5)cc34)ccc2c1 CHEMBL4641174 IC50 356.0 nM
CNC1CCN(c2nc(-c3ccncc3)nc3sc4c(c23)CCCC4)CC1 CHEMBL4645321 IC50 360.0 nM
NC1CCN(c2nc(-c3ccncc3)nc3sc4c(c23)CCCC4)CC1 CHEMBL4647507 IC50 380.0 nM
Cc1n[nH]c2cnc(-c3cncc(OCC(N)Cc4cccc(C(F)(F)F)c4)c3)cc12 CHEMBL1998159 pKi 398.11 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL1970903 pKi 398.11 nM
CC(=NNC(=N)N)c1cc(NC(=O)NCCCCCCNC(=O)Nc2cc(C(C)=NNC(=N)N)cc(C(C)=NNC(=N)N)c2)cc(C(C)=NNC(=N)N)c1 CHEMBL1991728 pKi 398.11 nM
Oc1ccc(C2CC(c3cccs3)=NN2c2ccc(C(F)(F)F)cc2)cc1 CHEMBL3323344 IC50 400.0 nM
Oc1ccc(C2=NN(c3cccc(Cl)c3)C(c3cccc(Cl)c3)C2)cc1 CHEMBL4290590 IC50 400.0 nM
NCCN1CCN(c2nc(-c3ccncc3)nc3sc4c(c23)CCCC4)CC1 CHEMBL4635556 IC50 420.0 nM
CC(C)(C)C1=NN(c2ccc(F)c(F)c2)C(c2ccc(O)cc2)C1 CHEMBL3323331 IC50 500.0 nM
Oc1ccc(C2CC(c3cccs3)=NN2c2ccc(Br)cc2)cc1 CHEMBL3323343 IC50 500.0 nM
Oc1ccc(C2CC(c3ccc[nH]3)=NN2c2cccc(Cl)c2)cc1 CHEMBL3323346 IC50 500.0 nM
NCC1CCN(c2nc(-c3ccncc3)nc3sc4c(c23)CCCC4)CC1 CHEMBL4637651 IC50 520.0 nM
C=C(C)C(CC[C@@H](C)[C@H]1CC[C@@]2(C)[C@@H]3C[C@H](OS(=O)(=O)[O-])[C@H]4[C@@H](O)[C@H](OS(=O)(=O)[O-])[C@@H](OS(=O)(=O)[O-])C[C@]4(C)C3=CC[C@]12C)C(C)C CHEMBL475118 IC50 530.0 nM
CN(C)C1CCN(c2nc(-c3ccncc3)nc3sc4c(c23)CCCC4)CC1 CHEMBL4640268 IC50 560.0 nM
CNc1ccc(-c2ccc3c(-c4nc5c(N6CCN(C)CC6)cccc5[nH]4)n[nH]c3c2)cc1 CHEMBL474441 IC50 585.0 nM
Oc1ccc(C2CC(c3cccs3)=NN2c2ccc(Cl)cc2)cc1 CHEMBL3323342 IC50 600.0 nM
Nc1ccc(-c2cncc3ccc(OC[C@@H]4CCNC4)cc23)cc1 CHEMBL4644160 IC50 604.0 nM
CC(=NNC(=N)N)c1cc(NC(=O)NCCCN(C)CCCNC(=O)Nc2cc(C(C)=NNC(=N)N)cc(C(C)=NNC(=N)N)c2)cc(C(C)=NNC(=N)N)c1 CHEMBL1993166 pKi 630.96 nM
OC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1991674 pKi 630.96 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 630.96 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 630.96 nM
c1ccc2sc(-c3cncc4ccc(O[C@H]5CCNC5)cc34)nc2c1 CHEMBL4644798 IC50 631.0 nM
CC(C)(C)C1=NN(c2ccc(F)c(F)c2F)C(c2ccc(O)cc2)C1 CHEMBL3323334 IC50 700.0 nM
CC(C)(C)C1=NN(c2ccc(Cl)cc2)C(c2ccc(O)c(Cl)c2)C1 CHEMBL3323357 IC50 700.0 nM
c1cc(-c2nc(NC3CCNCC3)c3c4c(sc3n2)CCCC4)ccn1 CHEMBL4633210 IC50 700.0 nM
CC1C(c2ccccc2O)=NN(c2cccc(Cl)c2)C1c1ccc(O)c(F)c1 CHEMBL3323364 IC50 720.0 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1Cl CHEMBL1965660 pKi 794.33 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccc(Cl)c(Cl)c4)c3)cc12 CHEMBL1991063 pKi 794.33 nM
Oc1ccc(C2=NN(c3ccc(Cl)cc3)C(c3ccc(Cl)cc3)C2)cc1O CHEMBL4283413 IC50 800.0 nM
CC(C)(C)C1=NN(c2ccc(F)c(Cl)c2)C(c2ccc(O)cc2)C1 CHEMBL3323330 IC50 900.0 nM
NC(COc1cncc(-c2cc3cnccc3s2)c1)Cc1c[nH]c2ccccc12 CHEMBL1972840 pKi 1000.0 nM
CSc1cnc2c(ccc3cnccc32)c1O CHEMBL2006933 pKi 1000.0 nM
CC(Nc1c(Nc2ccncc2)c(=O)c1=O)C(C)(C)C CHEMBL1986186 pKi 1000.0 nM
CC(=O)N(c1ccncc1)c1c(NC(C)C(C)(C)C)c(=O)c1=O CHEMBL2005899 pKi 1000.0 nM
NCCC(C(=O)Nc1ccc2[nH]ncc2c1)c1ccc(Cl)c(Cl)c1 CHEMBL1998121 pKi 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM