c1cc2c(N3CCNCC3)nc(-c3ccnc(NC4CCOCC4)c3)cc2cn1 CHEMBL1215711 IC50 0.4 nM
c1cc2c(N3CCNCC3)nc(-c3ccnc(NC4CCCCC4)c3)cc2cn1 CHEMBL1214998 IC50 0.6 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2C2CC3C2)no1 CHEMBL4113471 Ki 0.9 nM
NCC1CCN(c2nc(-c3ccnc(NC4CCCCC4)c3)cc3cnccc23)CC1 CHEMBL1215710 IC50 1.0 nM
CC(C)CN1CCN(c2nc(-c3ccnc(NC4CCOCC4)c3)cc3cnccc23)CC1 CHEMBL1215712 IC50 1.0 nM
O=C(NC1CCNCC1)C1CCN(c2nc(-c3ccnc(NC4CCCCC4)c3)cc3cnccc23)CC1 CHEMBL1214711 IC50 1.0 nM
O=C(NCCN1CCCC1)C1CCN(c2nc(-c3ccnc(NC4CCCCC4)c3)cc3cnccc23)CC1 CHEMBL1214712 IC50 1.0 nM
O=C(NCCN1CCCC1)C1CCN(c2nc(-c3ccnc(NC4CCOCC4)c3)cc3cnccc23)CC1 CHEMBL1214860 IC50 1.0 nM
O=C1NCc2c1cc(N1CCNCC1)nc2-c1ccnc(NC2CCCCC2)c1 CHEMBL1215363 IC50 1.0 nM
NC(=O)c1cc(-c2ccnc(NC3CCCCC3)c2)nc(N2CCNCC2)c1 CHEMBL1214999 IC50 1.0 nM
NC(=O)c1cc(-c2ccnc(Nc3ccccc3)c2)nc(N2CCNCC2)c1 CHEMBL1215000 IC50 1.0 nM
NC(=O)c1cc(-c2ccnc(NC3CCOCC3)c2)nc(N2CCNCC2)c1 CHEMBL1215001 IC50 1.0 nM
CC(C)Nc1cc(-c2cc(C(N)=O)cc(N3CCNCC3)n2)ccn1 CHEMBL1215002 IC50 1.0 nM
Cn1ccc(Nc2cc(-c3cc(C(N)=O)cc(N4CCNCC4)n3)ccn2)n1 CHEMBL1215074 IC50 1.0 nM
NC(=O)c1cc(-c2ccnc(Nc3ccccc3Cl)c2)nc(N2CCNCC2)c1 CHEMBL1215075 IC50 1.0 nM
NC(=O)c1cc(-c2ccnc(N3CCCCC3)c2)nc(N2CCNCC2)c1 CHEMBL5440043 IC50 1.0 nM
CCOc1ccc2cc(-c3cc(-c4cccc(C(=O)NCCN(C)C)c4)cnc3N)ccc2c1 CHEMBL5419827 IC50 1.0 nM
CC[C@H](N)CNc1ccnc(-c2cc(-c3cnn(C)c3)ccc2O)n1 CHEMBL5428541 IC50 1.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 1.35 nM
CN1CCN(c2nc(-c3ccnc(NC4CCCCC4)c3)cc3cnccc23)CC1 CHEMBL1215641 IC50 2.0 nM
c1cc2c(N3CCN(CC4CC4)CC3)nc(-c3ccnc(NC4CCCCC4)c3)cc2cn1 CHEMBL1215643 IC50 2.0 nM
NC(=O)C1CCN(c2nc(-c3ccnc(NC4CCOCC4)c3)cc3cnccc23)CC1 CHEMBL1214788 IC50 2.0 nM
CC(C)CNC(=O)C1CCN(c2nc(-c3ccnc(NC4CCOCC4)c3)cc3cnccc23)CC1 CHEMBL1214858 IC50 2.0 nM
O=C(NCCO)C1CCN(c2nc(-c3ccnc(NC4CCOCC4)c3)cc3cnccc23)CC1 CHEMBL1214859 IC50 2.0 nM
NC(=O)c1cc(N[C@@H]2CCNC2)nc(-c2ccnc(NC3CCCCC3)c2)c1 CHEMBL1215220 IC50 2.0 nM
C[C@@H]1CN(c2nc(-c3ccnc(NC4CCCCC4)c3)cc3cnccc23)C[C@H](C)N1 CHEMBL1215640 IC50 3.0 nM
CNC(=O)C1CCN(c2nc(-c3ccnc(NC4CCCCC4)c3)cc3cnccc23)CC1 CHEMBL1214710 IC50 3.0 nM
CCNC(=O)C1CCN(c2nc(-c3ccnc(NC4CCOCC4)c3)cc3cnccc23)CC1 CHEMBL1214789 IC50 3.0 nM
CC(C)NC(=O)C1CCN(c2nc(-c3ccnc(NC4CCOCC4)c3)cc3cnccc23)CC1 CHEMBL1214857 IC50 3.0 nM
CCOc1nc2ccc(C#C[C@@](C)(O)c3ncc(C)o3)cc2n1-c1ccnc(N)n1 CHEMBL4524153 Ki 3.6 nM
CC(C)NCc1ccc(-c2cc(-c3cccc(C(=O)N[C@H](C)C#N)c3)n[nH]2)cc1 CHEMBL1683435 IC50 3.7 nM
O=C(C1CCN(c2nc(-c3ccnc(NC4CCCCC4)c3)cc3cnccc23)CC1)N1CCC(O)CC1 CHEMBL1214786 IC50 4.0 nM
CCNc1cc(-c2cc(C(N)=O)cc(N3CCNCC3)n2)ccn1 CHEMBL1215077 IC50 4.0 nM
c1cc(-c2cc(-c3cc[nH]n3)cc(N3CCNCC3)n2)cc(NC2CCCCC2)n1 CHEMBL1215152 IC50 4.0 nM
Cc1cnc([C@@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2C2CC3C2)o1 CHEMBL3957252 Ki 4.2 nM
Cc1cc([C@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2CCO3)no1 CHEMBL4115120 Ki 4.9 nM
NCC(=O)N1CCN(c2nc(-c3ccnc(NC4CCOCC4)c3)cc3cnccc23)CC1 CHEMBL1214787 IC50 5.0 nM
N#Cc1cc(-c2ccnc(Nc3ccccc3)c2)nc(N2CCNCC2)c1 CHEMBL1215149 IC50 5.0 nM
C[C@H](C#N)NC(=O)c1cccc(-c2cc(-c3ccc(CNC4CCOCC4)cc3)on2)c1 CHEMBL1683440 IC50 5.5 nM
Cc1cc([C@](C)(O)C#Cc2cc3c(cc2F)C2CC(C2)n2cc(C(N)=O)nc2-3)no1 CHEMBL4073390 Ki 5.9 nM
CC(C)CN1CCN(c2nc(-c3ccnc(NC4CCCCC4)c3)cc3cnccc23)CC1 CHEMBL1215642 IC50 6.0 nM
NC(=O)c1cc(-c2ccnc(NC3CCCC3)c2)nc(N2CCNCC2)c1 CHEMBL1215076 IC50 6.0 nM
C[C@@H]1CN(c2cc(C(N)=O)cc(-c3ccnc(NC4CCCCC4)c3)n2)CCN1 CHEMBL1215222 IC50 6.0 nM
COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL281948 IC50 7.0 nM
Cn1ccc(Nc2cc(-c3cc(C#N)cc(N4CCNCC4)n3)ccn2)n1 CHEMBL1215150 IC50 8.0 nM
C[C@H]1CN(c2cc(C(N)=O)cc(-c3ccnc(NC4CCCCC4)c3)n2)CCN1 CHEMBL1215223 IC50 8.0 nM
CC(C)NCc1ccc(-c2cc(-c3cccc(C(=O)N[C@H](C)C#N)c3)no2)cc1 CHEMBL1683436 IC50 9.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 IC50 10.0 nM
c1ccc2c(N3CCNCC3)nc(-c3ccnc(NC4CCCCC4)c3)cc2c1 CHEMBL1215505 IC50 12.0 nM
c1cc2c(N3CCN(C4CC4)CC3)nc(-c3ccnc(NC4CCCCC4)c3)cc2cn1 CHEMBL1215709 IC50 13.0 nM
NC(=O)c1cc(-c2ccnc(NC3CCCCC3)c2)nc(N2CCCC(N)C2)c1 CHEMBL1215285 IC50 14.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 14.0 nM
Cc1cc([C@@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2CCO3)no1 CHEMBL3896516 Ki 14.0 nM
c1cnc2cc(-c3ccnc(NC4CCCCC4)c3)nc(N3CCNCC3)c2c1 CHEMBL1215572 IC50 15.0 nM
OC1CCN(c2nc(-c3ccnc(NC4CCCCC4)c3)cc3cnccc23)CC1 CHEMBL1215793 IC50 15.0 nM
CC[C@@H](N)CNc1ccnc(-c2cc(-c3cnn(C)c3)ccc2O)n1 CHEMBL4515390 IC50 16.0 nM
CC(CO)Nc1cc(-c2[nH]c3cccnc3c2-c2ccc(F)cc2)ccn1 CHEMBL5413306 IC50 16.0 nM
FC(F)c1cc(-c2ccnc(NC3CCCCC3)c2)nc(N2CCNCC2)c1 CHEMBL1215361 IC50 17.0 nM
c1cc(-c2cc(-c3cn[nH]c3)cc(N3CCNCC3)n2)cc(NC2CCCCC2)n1 CHEMBL1215151 EC50 17.0 nM
N#Cc1cc(-c2ccnc(NC3CCCCC3)c2)nc(N2CCNCC2)c1 CHEMBL1215078 IC50 18.0 nM
CC(=O)C1CN(c2nc(-c3ccnc(NC4CCCCC4)c3)cc3cnccc23)CCN1 CHEMBL1215795 IC50 19.0 nM
N#CCNC(=O)c1cccc(-c2cc(-c3ccc(CNC4CCOCC4)cc3)on2)c1 CHEMBL1683438 IC50 19.0 nM
FC(F)(F)c1cc(-c2ccnc(NC3CCCCC3)c2)nc(N2CCNCC2)c1 CHEMBL1215360 IC50 20.0 nM
Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCC#N)c4c21)CNC3=O CHEMBL302449 IC50 20.0 nM
CN1CCN(c2cc(C(N)=O)cc(-c3ccnc(NC4CCCCC4)c3)n2)CC1 CHEMBL1215286 IC50 25.0 nM
NC(=O)c1cn2c(n1)-c1cc(C#CC3(O)CCCC3)ccc1C1CC2C1 CHEMBL3692392 Ki 25.0 nM
O=C1NCCSc2c1sc1ccc(O)cc21 CHEMBL1672571 IC50 28.3 nM
O=C1NCc2c1cc(-c1ccnc(NC3CCCCC3)c1)nc2N1CCNCC1 CHEMBL1215362 IC50 35.0 nM
C[C@@H]1CCNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n21 CHEMBL1933288 IC50 35.0 nM
Nc1ncnc2c1c(-c1c[nH]c3ccccc13)nn2CC1CCNCC1 CHEMBL4787572 IC50 35.0 nM
c1ccc2c(N3CCNCC3)nc(-c3ccnc(NC4CCCCC4)c3)nc2c1 CHEMBL1215573 IC50 43.0 nM
NC(=O)c1cn2c(n1)-c1cc(C#CC3CCCC3)ccc1C1CC2C1 CHEMBL4461552 Ki 44.0 nM
NCC1CCN(c2cc(C(N)=O)cc(-c3ccnc(NC4CCCCC4)c3)n2)CC1 CHEMBL1215287 IC50 46.0 nM
CC(C)(C#N)NC(=O)c1cccc(-c2cc(-c3ccc(CNC4CCOCC4)cc3)on2)c1 CHEMBL1683439 IC50 49.0 nM
Clc1cc(-c2cc3cnccc3c(N3CCNCC3)n2)ccn1 CHEMBL1214933 IC50 50.0 nM
CC(C)(CO)Cn1nc(-c2c[nH]c3ccccc23)c2c(N)ncnc21 CHEMBL4790321 IC50 50.0 nM
Cc1ccnc(-c2nc(Nc3ccc4ncoc4c3)c3ccccc3n2)c1 CHEMBL5398617 IC50 53.0 nM
CC1(C)CN(c2cc(C(N)=O)cc(-c3ccnc(NC4CCCCC4)c3)n2)CCN1 CHEMBL1215288 IC50 55.0 nM
Cc1ccnc(-c2nc(Nc3ccc4ncsc4c3)c3ccccc3n2)c1 CHEMBL5409768 Kd 56.0 nM
c1cc(-c2cc3cnccc3c(N3CCNCC3)n2)ccn1 CHEMBL1214932 IC50 59.0 nM
C[C@H](C#N)NC(=O)c1cccc(-c2cc(-c3ccc(N4CCN(C)CC4)cc3)on2)c1 CHEMBL1683431 IC50 60.0 nM
CCOc1nc2ccc(C#C[C@](C)(O)c3ncc(C)o3)cc2n1-c1ccnc(N)n1 CHEMBL4546659 Ki 62.0 nM
Nc1ncnc2c1c(-c1cccc3ccccc13)nn2CC1CCNCC1 CHEMBL4776166 IC50 64.0 nM
Cc1cc([C@@](C)(O)C#Cc2ccc3c(c2)-c2nc(C(N)=O)cn2C2CC3C2)no1 CHEMBL3978002 Ki 65.0 nM
NC(=O)c1cc(N[C@H]2CCNC2)nc(-c2ccnc(NC3CCCCC3)c2)c1 CHEMBL1215221 IC50 68.0 nM
[N-]=[N+]=Nc1ccc2sc3c(c2c1)SCCNC3=O CHEMBL1672572 IC50 74.9 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 80.0 nM
COc1ccc2sc3c(c2c1)SCCNC3=O CHEMBL319170 IC50 82.5 nM
NC(=O)C1CCN(c2nc(-c3ccnc(NC4CCCCC4)c3)cc3cnccc23)CC1 CHEMBL1214709 IC50 83.0 nM
CN1CCN(c2ccc(-c3cc(-c4cccc(C(=O)NCC#N)c4)n[nH]3)cc2Br)CC1 CHEMBL1683424 IC50 87.0 nM
CC(C)Nc1cc(-c2cc(-c3cn[nH]c3)cc(N3CCNCC3)n2)ccn1 CHEMBL1215153 EC50 92.0 nM
C[C@@H](C#N)NC(=O)c1cccc(-c2cc(-c3ccc(CNC4CCOCC4)cc3)on2)c1 CHEMBL1683441 IC50 95.0 nM
CC(C)NCc1ccc(-c2cc(-c3cccc(C(=O)NC(C)C)c3)n[nH]2)cc1 CHEMBL1683433 IC50 100.0 nM
Fc1ccc(Cl)cc1-c1nc(Nc2ccncc2)c2nccnc2n1 CHEMBL238125 IC50 106.0 nM
CC(C)(C)n1nc(-c2c[nH]c3ccccc23)c2c(N)ncnc21 CHEMBL4779081 IC50 108.0 nM
O=C1NCCCSc2c1sc1ccc(O)cc21 CHEMBL1672573 IC50 111.0 nM
COc1ncc2sc3c(c2n1)SCCNC3=O CHEMBL1672575 IC50 124.0 nM
O=C1NCCCc2c1[nH]c1ccc(O)cc21 CHEMBL1672570 IC50 130.0 nM
Cc1ccnc(-c2nc(Nc3ccc4[nH]ccc4c3)c3ccccc3n2)c1 CHEMBL5413338 Kd 130.0 nM
CN1CCN(c2ccc(-c3cc(-c4cccc(C(=O)NCC#N)c4)n[nH]3)cc2)CC1 CHEMBL1683423 IC50 140.0 nM
CC(C)(C)n1nc(-c2cccc3ccccc23)c2c(N)ncnc21 CHEMBL264406 IC50 155.0 nM
O=C1NCCCc2c1oc1ccc(O)cc21 CHEMBL1450770 IC50 182.0 nM
CCOc1ccc2cc(-c3nn(CC4CCN(C)CC4)c4ncnc(N)c34)ccc2n1 CHEMBL4576165 IC50 183.0 nM
c1cc2cc(-c3ccnc(NC4CCCCC4)c3)nc(N3CCNCC3)c2cn1 CHEMBL1215571 IC50 191.0 nM
COc1ccc2sc3c(c2c1)SCCCNC3=O CHEMBL1672574 IC50 193.0 nM
CC(C)NC(=O)c1cccc(-c2cc(-c3ccc(N4CCN(C)CC4)c(-c4ccncc4)c3)[nH]n2)c1 CHEMBL1683422 IC50 200.0 nM
CN1CCN(c2ccc(-c3cc(-c4cccc(C(=O)NCC#N)c4)no3)cc2)CC1 CHEMBL1683430 IC50 200.0 nM
CC(C)NC(=O)c1cccc(-c2cc(-c3ccc(CNC4CCOCC4)cc3)on2)c1 CHEMBL1683437 IC50 220.0 nM
c1cc(-c2cc(-c3cn[nH]c3)cc(N3CCNCC3)n2)cc(NC2CCOCC2)n1 CHEMBL1215219 EC50 234.0 nM
Cc1ccnc(-c2nc(Nc3ccc4occc4c3)c3ccccc3n2)c1 CHEMBL5408764 Kd 240.0 nM
CC(C)(C)n1nc(Cc2cccc3ccccc23)c2c(N)ncnc21 CHEMBL573578 IC50 250.0 nM
CC(C)NC(=O)c1cccc(-c2cc(-c3ccc(N4CCN(C)CC4)c(Br)c3)[nH]n2)c1 CHEMBL1683314 IC50 280.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 310.0 nM
CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc2N1C1CCCC1 CHEMBL513909 Kd 320.0 nM
NCCNc1nc(-c2ccncc2)cc2cnccc12 CHEMBL1214929 IC50 321.0 nM
CC(C)(C)n1nc(-c2c[nH]c3cccnc23)c2c(N)ncnc21 CHEMBL4778331 IC50 343.0 nM
OCCNc1nc(-c2ccnc(NC3CCCCC3)c2)cc2cnccc12 CHEMBL1215792 IC50 382.0 nM
CC(C)NC(=O)c1cccc(-c2cc(-c3ccc(CNC4CC4)cc3)[nH]n2)c1 CHEMBL1683312 IC50 390.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 420.0 nM
C[C@@H](C#N)NC(=O)c1cccc(-c2cc(-c3ccc(N4CCN(C)CC4)cc3)on2)c1 CHEMBL1683432 IC50 430.0 nM
COCCNCc1ccc(-c2cc(-c3cccc(C(=O)NC(C)C)c3)n[nH]2)cc1 CHEMBL1683311 IC50 430.0 nM
COc1cc(O)c2c(c1)[C@H]1O[C@@H]1C[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O CHEMBL471474 IC50 500.0 nM
O=c1[nH]ccc2cc(O[C@H]3CCCNC3)ccc12 CHEMBL1667967 pIC50 501.19 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1 CHEMBL428690 Kd 520.0 nM
Cc1cccc(-c2[nH]c(Cc3cccc(C(N)=O)c3)nc2-c2ccc3ncccc3c2)n1 CHEMBL1164957 IC50 650.0 nM
CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3c(cc2OC)CCN3C(=O)CN(C)C)nc2[nH]ccc12 CHEMBL464552 Kd 650.0 nM
c1cnc2c(N3CCNCC3)nc(-c3ccnc(NC4CCCCC4)c3)cc2c1 CHEMBL1215570 IC50 695.0 nM
CN1CCN(c2ccc(-c3cc(-c4cccc(C(=O)NCCC#N)c4)n[nH]3)cc2)CC1 CHEMBL1683425 IC50 750.0 nM
CNc1cc(-c2cc3cnccc3c(NCCCO)n2)ccn1 CHEMBL1214931 IC50 764.0 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL180022 Kd 820.0 nM
CC(C)NC(=O)c1cccc(-c2cc(-c3ccc(N4CCN(C)CC4)c(-c4ccccc4)c3)[nH]n2)c1 CHEMBL1683315 IC50 980.0 nM
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL601719 Kd 990.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 990.0 nM
Cc1cccc(-c2[nH]c(CNc3cccc(C#N)c3)nc2-c2ccc3nccnc3c2)n1 CHEMBL387748 IC50 1000.0 nM
CC(C)NC(=O)c1cccc(-c2cc(-c3ccc(N4CCN(C)CC4)cc3)[nH]n2)c1 CHEMBL1683313 IC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM
Cc1ccnc(-c2nc(Nc3ccc4ocnc4c3)c3ccccc3n2)c1 CHEMBL5437196 Kd 1000.0 nM