NC(=O)c1cc(-c2ccnc(N3CCCCC3)c2)nc(N2CCNCC2)c1 CHEMBL5440043 IC50 1.0 nM
CCOc1ccc2cc(-c3cc(-c4cccc(C(=O)NCCN(C)C)c4)cnc3N)ccc2c1 CHEMBL5419827 IC50 1.5 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 1.52 nM
CC[C@H](N)CNc1ccnc(-c2cc(-c3cnn(C)c3)ccc2O)n1 CHEMBL5428541 IC50 2.0 nM
CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccccc3n2)CC1 CHEMBL565612 IC50 2.1 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12 CHEMBL400402 Kd apparent 3.0 nM
CCn1c(C)c(-c2ccnc(Nc3cccc(OC)c3)n2)sc1=O CHEMBL1986263 pKi 3.981 nM
O=C1NCCc2[nH]c(-c3ccnc(C=Cc4ccccc4)c3)cc21 CHEMBL1997129 pKi 3.981 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 3.981 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccc(Cl)c(Cl)c4)c3)cc12 CHEMBL1991063 pKi 3.981 nM
Cn1cc(Nc2ncc(Br)c(Nc3ccccc3C(N)=O)n2)cn1 CHEMBL1994669 pKi 5.012 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL1970903 pKi 5.012 nM
NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1973720 pKi 5.012 nM
CNC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2005509 pKi 5.012 nM
CC[C@@H](N)CNc1ccnc(-c2cc(-c3cnn(C)c3)ccc2O)n1 CHEMBL4515390 IC50 6.0 nM
NC1CCC(Nc2nccc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1966628 pKi 6.31 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 6.31 nM
Cn1cc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cn1 CHEMBL1984548 pKi 7.943 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 7.943 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 8.9 nM
NC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1983589 pKi 10.0 nM
CC(C)Cn1c(N)nc2ccc(-c3c(-c4ccc(F)cc4)nc4sccn34)cc21 CHEMBL1965423 pKi 10.0 nM
CCNC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1992220 pKi 10.0 nM
NCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1972290 pKi 12.59 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccc[nH]2)C(=O)N3)c1)Cc1ccccc1 CHEMBL1980407 pKi 15.85 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL244378 pKi 15.85 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 15.85 nM
CN(C)C1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1969151 pKi 15.85 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 15.85 nM
C[C@H](C#N)NC(=O)c1cccc(-c2cc(-c3ccc(CNC4CCOCC4)cc3)on2)c1 CHEMBL1683440 IC50 17.0 nM
Nc1ncnc2c1c(-c1c[nH]c3ccccc13)nn2CC1CCNCC1 CHEMBL4787572 IC50 17.0 nM
NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(-c3ccncc3)ccc2c1=O CHEMBL340384 pKi 19.95 nM
Nc1nc2ccc(-c3c(-c4ccc(F)cc4)nc4sccn34)cc2n1CC1CC1 CHEMBL1982874 pKi 19.95 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 31.62 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(OC(F)(F)F)c4)c3)cc12 CHEMBL1965836 pKi 31.62 nM
NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1998432 pKi 31.62 nM
COc1ccc(-c2cc3nccn3c(Nc3ncccc3C(N)=O)n2)cc1OC CHEMBL1190711 pKi 31.62 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 pKi 31.62 nM
COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL281948 Kd apparent 38.0 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 39.81 nM
CCN1CCN(c2ccc(Nc3nccc(-c4c(-c5cccc(C(=O)Nc6ccccc6F)c5)nc5ccccn45)n3)cc2)CC1 CHEMBL1981725 pKi 39.81 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 39.81 nM
CCOc1ccc2cc(-c3nn(CC4CCN(C)CC4)c4ncnc(N)c34)ccc2n1 CHEMBL4576165 IC50 43.0 nM
CCN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1967998 pKi 50.12 nM
CC(C)CNC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2006456 pKi 50.12 nM
CNCC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1996980 pKi 50.12 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 50.12 nM
CC(C)Cn1c(N)nc2c(F)cc(-c3c(-c4ccc(F)cc4)nc4sccn34)cc21 CHEMBL2004419 pKi 50.12 nM
CNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCNCC4)cc3)n2)s1 CHEMBL1999484 pKi 50.12 nM
O=C1NCCSc2c1sc1ccc(O)cc21 CHEMBL1672571 IC50 53.0 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(-c4ccccc4)c3n2)c1 CHEMBL1988163 pKi 63.1 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1Cl CHEMBL1965660 pKi 63.1 nM
NC(=O)c1cccc(-c2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982957 pKi 63.1 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 CHEMBL49120 pKi 63.1 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(F)c2)n1 CHEMBL243298 pKi 63.1 nM
Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1987448 pKi 63.1 nM
CC(Nc1nccc(-c2c(-c3ccc(F)cc3)nc3occn23)n1)c1ccccc1 CHEMBL1990288 pKi 63.1 nM
CC(C)CC(=O)Nc1n[nH]c2c1CN(C(=O)C1CCN(C)CC1)C2(C)C CHEMBL1230607 Kd apparent 65.0 nM
CC(C)(CO)Cn1nc(-c2c[nH]c3ccccc23)c2c(N)ncnc21 CHEMBL4790321 IC50 76.0 nM
Nc1ncnc2c1c(-c1cccc3ccccc13)nn2CC1CCNCC1 CHEMBL4776166 IC50 78.0 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 79.43 nM
CS(=O)(=O)NCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL2005718 pKi 79.43 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1F CHEMBL1981079 pKi 79.43 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCOCC2)n1 CHEMBL1980253 pKi 79.43 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 79.43 nM
Cc1cccc(Nc2nc(NC3CCCCC3N)cnc2C(N)=O)c1 CHEMBL1974328 pKi 79.43 nM
CC(C)(C)c1nc2c3ccc(F)cc3c3c(=O)[nH]ccc3c2[nH]1 CHEMBL21156 pKi 79.43 nM
c1cc(OCCN2CCCCC2)cc(-c2n[nH]c3ccc(-c4nnc[nH]4)cc23)c1 CHEMBL1614713 Kd apparent 90.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 93.0 nM
CC(C)(CN)CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1985723 pKi 100.0 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 pKi 100.0 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 pKi 100.0 nM
CCNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)n2)s1 CHEMBL1983715 pKi 100.0 nM
Nc1ncnc(Nc2cc(CNC(=O)C(F)(F)F)c(O)c(-c3ccc(Cl)cc3)c2)n1 CHEMBL2001239 pKi 100.0 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1979690 pKi 100.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(O)c2)n1 CHEMBL243088 pKi 100.0 nM
CC(C)(C)n1nc(-c2cccc3ccccc23)c2c(N)ncnc21 CHEMBL264406 IC50 104.0 nM
Fc1ccc(Cl)cc1-c1nc(Nc2ccncc2)c2nccnc2n1 CHEMBL238125 IC50 105.0 nM
CC(C)(C)n1nc(-c2c[nH]c3ccccc23)c2c(N)ncnc21 CHEMBL4779081 IC50 108.0 nM
CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1 CHEMBL2028663 Kd apparent 120.0 nM
CCC1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc2N1C1CCCC1 CHEMBL1968380 pKi 125.89 nM
Cc1n[nH]c2ccc(-c3cncc(OCCN)c3)cc12 CHEMBL1967887 pKi 125.89 nM
CN1CCN(c2ccc(-c3cnc4c(c3)N(Cc3c(F)ccc(F)c3Cl)CCN4)cn2)CC1 CHEMBL1164265 pKi 125.89 nM
O=C(NCC1CCCCC1)c1cc2c(-c3ccccc3)n[nH]c2s1 CHEMBL2005475 pKi 125.89 nM
NCCC(C(=O)Nc1ccc2[nH]ncc2c1)c1ccc(Cl)c(Cl)c1 CHEMBL1998121 pKi 125.89 nM
CNC(=O)c1nn(C)c2c1C(C)(C)Cc1cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc1-2 CHEMBL564829 Kd apparent 135.0 nM
NCCCOc1cc2c(c(-c3ccc(Nc4nc5ccc(Cl)cc5o4)cc3)c1)CNC2=O CHEMBL2002479 pKi 158.49 nM
O=C(NCc1ccc(Cl)cc1)c1cc2c(-c3ccccc3)n[nH]c2s1 CHEMBL1967094 pKi 158.49 nM
NC(COc1cncc(-c2ccc3c(c2)CC(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL1967302 pKi 158.49 nM
OC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1991674 pKi 158.49 nM
Cc1cccc(Nc2nccc(Nc3c(NC(C)C(C)(C)C)c(=O)c3=O)n2)c1 CHEMBL1969523 pKi 158.49 nM
Clc1cc(-c2c[nH]c3ncccc23)cc(NCc2ccccc2)n1 CHEMBL1969588 pKi 158.49 nM
COc1cc2ncc3c(N)nc4c(C)c(N)ccc4c3c2cc1OC CHEMBL235157 pKi 158.49 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccccc4)c3)cc12 CHEMBL2002726 pKi 158.49 nM
CC(C)(CN)CNc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL1968930 pKi 158.49 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1 CHEMBL428690 Kd 170.0 nM
Cc1cccc(-c2[nH]c(-c3ccnc(N)n3)cc2C(N)=O)c1C CHEMBL1964290 pKi 199.53 nM
CNC(=O)c1cc2c(-c3ccccc3F)n[nH]c2s1 CHEMBL1977681 pKi 199.53 nM
CC(Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL1825138 pKi 199.53 nM
Fc1ccc(-c2nc3occn3c2-c2ccnc(NC3CCNCC3)n2)cc1 CHEMBL1971186 pKi 199.53 nM
c1ccc(CNc2nc(Nc3cc(C4CC4)[nH]n3)c3sccc3n2)cc1 CHEMBL1997924 pKi 199.53 nM
Cc1cc(=O)n2ccc(CN(C)C)c(O)c2n1 CHEMBL1988581 pKi 199.53 nM
NC1CCCCC1Nc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL1994438 pKi 199.53 nM
NC(COc1cncc(-c2ccc3cnccc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL1981133 pKi 199.53 nM
Fc1ccc(-c2nc3cnccn3c2-c2ccnc(NCC3CC3)n2)cc1 CHEMBL1990904 pKi 199.53 nM
CNC(=O)C=Cc1cnc(N)c2c(-c3ccc4sc(C)nc4c3)csc12 CHEMBL1968590 pKi 199.53 nM
COc1cccc(CNC(=O)c2cc3c(-c4ccccc4)n[nH]c3s2)c1 CHEMBL1987009 pKi 199.53 nM
CN1CCN(C2CCC(n3cc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1 CHEMBL1997617 pKi 199.53 nM
C[C@@H]1CCNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n21 CHEMBL1933288 IC50 219.0 nM
OCCNc1cc2cc(-c3cccnc3)ccc2cn1 CHEMBL1990912 pKi 251.19 nM
Cc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccc(F)cc3)cc12 CHEMBL1972339 pKi 251.19 nM
Nc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL2007574 pKi 251.19 nM
Nc1nccc(-c2c(-c3ccc(F)cc3)ncn2C2CCNCC2)n1 CHEMBL274064 pKi 251.19 nM
Nc1ncnc2c1c(-c1cnc3[nH]ccc3c1)nn2C1CCCC1 CHEMBL1081312 pKi 251.19 nM
CS(=O)(=O)NC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2005216 pKi 251.19 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4cnc5ccccc5c4)c3)cc21 CHEMBL226403 pKi 251.19 nM
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)c1 CHEMBL1090356 pKi 251.19 nM
Cc1nc(Nc2n[nH]c3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)c2sccc2n1 CHEMBL3128043 Kd apparent 268.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 280.0 nM
CC(C)(O)Cn1nc(-c2ccc3nc(OC4CC4)ccc3c2)c2c(N)ncnc21 CHEMBL4536241 IC50 280.0 nM
COCCN1CCN(Cc2ccc(-c3n[nH]c4c3C(=O)c3c(NC(=O)NN5CCOCC5)cccc3-4)cc2)CC1 CHEMBL3545083 Kd apparent 297.0 nM
CC(C)(CN)CNc1cc(-c2c[nH]c3ncccc23)cc(F)n1 CHEMBL1987261 pKi 316.23 nM
NC(COc1cncc(-c2ccc3[nH]c(=O)oc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL1987679 pKi 316.23 nM
CN1CCC(c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)C(O)C1 CHEMBL422897 pKi 316.23 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl CHEMBL458997 pKi 316.23 nM
NC(=O)c1cc2c(-c3ccc(Nc4nc5ccccc5o4)cc3)cnc(N)c2s1 CHEMBL1993904 pKi 316.23 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 316.23 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4ccccc4F)c3)cc21 CHEMBL226471 pKi 316.23 nM
COc1nccn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3F)nc12 CHEMBL1995832 pKi 316.23 nM
CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc2N1C1CCCC1 CHEMBL513909 Kd 350.0 nM
CC(C)(CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1)CNS(C)(=O)=O CHEMBL1971172 pKi 398.11 nM
CN1c2ccc(N)cc2C(c2ccccc2)c2cc(N)ccc21 CHEMBL1991734 pKi 398.11 nM
COc1cc2c(cc1Nc1nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN(C)C)CC2 CHEMBL461876 pKi 398.11 nM
COc1ccc(C2=NNc3cccc4c(OC)ccc2c34)cc1OC CHEMBL1997335 pKi 398.11 nM
CN(C)c1ccc(CNC(=O)c2cc3c(-c4ccccc4)n[nH]c3s2)cc1 CHEMBL1984367 pKi 398.11 nM
CC(N)C1CCC(C(=O)Nc2ccnc3[nH]ccc23)CC1 CHEMBL2002992 pKi 398.11 nM
CC(=O)NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1980178 pKi 398.11 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc([N+](=O)[O-])cc2)n1 CHEMBL242865 pKi 398.11 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 398.11 nM
COc1cc(-c2csc3c(C=CC(=O)NCCN(C)C)cnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C CHEMBL1989267 pKi 398.11 nM
CCN(CC)CCNC(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc3ccccc23)c1 CHEMBL1970290 pKi 398.11 nM
NC(=O)c1ccc(-c2c[nH]c3nccc(Cl)c23)cc1 CHEMBL1982711 pKi 398.11 nM
CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O CHEMBL189963 pKi 398.11 nM
O=C(O)c1ccccc1Nc1ncnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL1986666 pKi 398.11 nM
NC(=O)c1ccc2nc(-c3ccc([N+](=O)[O-])o3)cn2c1 CHEMBL1973359 pKi 398.11 nM
CCN(CCN)C(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc3ccccc23)c1 CHEMBL2004637 pKi 398.11 nM
CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3c(cc2OC)CCN3C(=O)CN(C)C)nc2[nH]ccc12 CHEMBL464552 Kd 410.0 nM
CC(C)(C)n1nc(-c2c[nH]c3cccnc23)c2c(N)ncnc21 CHEMBL4778331 IC50 456.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 480.0 nM
COc1cccc(Nc2ncnn3ccc(CN4CC[C@@H](N)[C@H](O)C4)c23)c1 CHEMBL3545396 Kd apparent 493.0 nM
COCCNc1nccc(-c2c(-c3ccc(F)cc3)nc3cnccn23)n1 CHEMBL1969372 pKi 501.19 nM
CC(C)(CO)CNc1nccc(-c2c(-c3ccc(F)cc3)nc3c(Cl)nccn23)n1 CHEMBL1969735 pKi 501.19 nM
CN(C)CCCOc1cc2c(c(-c3ccc(Nc4nc5ccccc5o4)cc3)c1)CNC2=O CHEMBL1966425 pKi 501.19 nM
CCc1nc(-c2cccc(C)c2)c(-c2ccnc(NC(=O)c3ccccc3)c2)s1 CHEMBL363648 pKi 501.19 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCCCCCCCCN)cnc(N)c34)cc2)c1 CHEMBL1978166 pKi 501.19 nM
Cc1cn2c(-c3ccnc(NCC(C)(C)CO)n3)c(-c3ccc(F)cc3F)nc2c(C)n1 CHEMBL2000408 pKi 501.19 nM
OC1CCCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1976936 pKi 501.19 nM
CC(=O)N1CCC(Nc2nccc(-c3c(-c4ccc(F)cc4)nc4occn34)n2)CC1 CHEMBL1986781 pKi 501.19 nM
CCOC(=O)c1ccc2[nH]c3c(c2c1)CCNC3=O CHEMBL2005528 pKi 501.19 nM
Brc1cnc2[nH]cc(-c3ccccc3)c2c1 CHEMBL1992634 pKi 501.19 nM
O=C(NN=Cc1cc(Br)c(O)c(Br)c1)Nc1ccccc1 CHEMBL1983575 pKi 501.19 nM
COC(C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 CHEMBL1981047 pKi 501.19 nM
CSc1ccccc1CNc1ncc([N+](=O)[O-])c(NCC2CCC(CN)CC2)n1 CHEMBL392642 pKi 501.19 nM
COc1ccc(CNc2cc(-c3c[nH]c4ncccc34)cc(F)n2)cc1 CHEMBL1986855 pKi 501.19 nM
CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1 CHEMBL2006765 pKi 501.19 nM
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL601719 Kd 510.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 532.0 nM
CN1C/C=C/CCOc2cccc(c2)-c2ccnc(n2)Nc2cccc(c2)C1 CHEMBL1944698 Kd apparent 557.0 nM
CC(C)(C)n1nc(Cc2cccc3ccccc23)c2c(N)ncnc21 CHEMBL573578 IC50 616.0 nM
O=C(c1cccc(CNc2n[nH]c3cccc(Cl)c23)c1)N1CCN(C(=O)c2ccc(Cl)cc2Cl)CC1 CHEMBL5393904 IC50 624.1 nM
CCN1CCN(c2ccc(Nc3ncc(C#N)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1973516 pKi 630.96 nM
COCC(C)(C)CNc1nccc(-c2c(-c3ccc(F)cc3)nc3c(C)nccn23)n1 CHEMBL1982563 pKi 630.96 nM
O=C1CCCN1Cc1ccc2c(c1)[nH]c(=O)c1cccn12 CHEMBL539474 pKi 630.96 nM
c1cc2cc(-c3ccc4cn[nH]c4c3)cnc2[nH]1 CHEMBL1976134 pKi 630.96 nM
NC(=O)c1sc2c(Br)ccc(Cl)c2c1N CHEMBL1998611 pKi 630.96 nM
CC(C)n1nnc2ccc(-c3c(-c4ccc(F)cc4F)nc4occn34)cc21 CHEMBL1969126 pKi 630.96 nM
CCN(C(C)=O)c1ccc(Nc2nc(NC3CC3)c3nc[nH]c3n2)cc1 CHEMBL2006564 pKi 630.96 nM
O=C1NN=Cc2c[nH]c3cc(NC(=O)C4CC4c4ccccc4)cc1c23 CHEMBL1969502 pKi 630.96 nM
CC(C)(CO)c1nnc2ccc(-c3c(-c4ccc(F)cc4F)nc4n3CCC4)nn12 CHEMBL1996587 pKi 630.96 nM
CCn1c(-c2nonc2N)nc2cncc(C(=O)N3CCC(N)C3)c21 CHEMBL1870106 pKi 630.96 nM
CC(C)(O)Cc1nnc2ccc(-c3c(-c4ccc(F)cc4F)nc4occn34)nn12 CHEMBL1976732 pKi 630.96 nM
CN1CCC(NC(=O)c2cc3c(-c4ccccc4)n[nH]c3s2)CC1 CHEMBL1987007 pKi 630.96 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccccc1 CHEMBL1999931 pKi 630.96 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 640.0 nM
N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL1078178 Kd apparent 650.0 nM
O=C(Nc1ccc(CN2CCOCC2)cc1)c1ccc(-c2cccc(Cl)c2)o1 CHEMBL1504776 IC50 700.0 nM
CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 CHEMBL296468 Kd 750.0 nM
C[C@@H](N)c1ccc(C(=O)Nc2ccnc3[nH]ccc23)cc1 CHEMBL571948 Kd apparent 762.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 780.0 nM
NC(=O)c1cc2c(-c3ccc(Br)cc3)cncc2s1 CHEMBL1978195 pKi 794.33 nM
CC(=O)Nc1cccc(CNc2c(Nc3ccc4[nH]ncc4c3)c(=O)c2=O)c1 CHEMBL1988608 pKi 794.33 nM
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCCC4=O)c3)n2)c1 CHEMBL1991429 pKi 794.33 nM
Nc1ncnc2c1sc1ncnc(N)c12 CHEMBL1976090 pKi 794.33 nM
O=C1NCCc2[nH]c(-c3ccncc3)cc21 CHEMBL225519 pKi 794.33 nM
NC(=O)c1sc2ccc(Cl)c(Cl)c2c1NC(=O)c1ccc(Cl)cc1 CHEMBL2003271 pKi 794.33 nM
COc1ccc2[nH]cc(C=C3C(=O)Nc4ccccc43)c2c1 CHEMBL1997275 pKi 794.33 nM
CS(=O)(=O)NCCOc1cncc(-c2ccc3cnccc3c2)c1 CHEMBL1964804 pKi 794.33 nM
COc1cccc(C(C)NC(=O)c2cc(C)c(-c3ccc4[nH]nc(C)c4c3)s2)c1 CHEMBL1997534 pKi 794.33 nM
c1cnc2nc(-c3ccc4[nH]ncc4c3)cn2c1 CHEMBL1682540 pKi 794.33 nM
Cc1cc(O)ccc1-n1cc(C(N)=O)c(=O)c2ccc(-c3ccncc3)cc21 CHEMBL340921 pKi 794.33 nM
O=C(O)c1ccccc1Nc1ncnc(Nc2cccc(F)c2)n1 CHEMBL1979933 pKi 794.33 nM
COc1c(-c2nc3ccccc3[nH]2)c(O)cc2oc(C)cc(=O)c12 CHEMBL1972355 pKi 794.33 nM
NC(COc1cncc(C=Cc2ccncc2)c1)Cc1c[nH]c2ccccc12 CHEMBL1974935 pKi 794.33 nM
O=C(Nc1cnccn1)Nc1ccnc2ccc(C(F)(F)F)cc12 CHEMBL1976455 pKi 794.33 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(F)c1 CHEMBL2003638 pKi 794.33 nM
O=C(Nc1cnccn1)Nc1cccc2c(O)cccc12 CHEMBL1992371 pKi 794.33 nM
CCOc1nc(C(=O)NCc2ccccc2S(N)(=O)=O)cc(N)c1C#N CHEMBL377408 pKi 794.33 nM
CC(C)(CO)CNc1nccc(-c2c(-c3ccc(F)cc3)nc3c(CCN)nccn23)n1 CHEMBL1982383 pKi 794.33 nM
CSc1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL17370 pKi 794.33 nM
Nc1nc(N)c2nc(-c3cccc(O)c3)c(-c3cccc(O)c3)nc2n1 CHEMBL230011 Kd 900.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OC[C@H]3CCCNC3)c21 CHEMBL494089 Kd 990.0 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccccc4)c3)cc12 CHEMBL379218 Kd 1000.0 nM
CC(=O)Nc1c(C(N)=O)sc2ccc(Cl)c(Cl)c12 CHEMBL1973142 pKi 1000.0 nM
O=C(NCc1ccc(Cl)c(Cl)c1)Nc1ccc2[nH]ncc2c1 CHEMBL1981782 pKi 1000.0 nM
C=CCn1c(=O)c2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2n1-c1cccc(C(C)(C)O)n1 CHEMBL1976040 pKi 1000.0 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3I)cc12 CHEMBL1975128 pKi 1000.0 nM
Cc1c(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc2n1C1CC(CN2CCCC2)C1 CHEMBL1968791 pKi 1000.0 nM
Cc1ccc(C(=O)Nc2c(C(N)=O)sc3ccc(Cl)c(Cl)c23)cc1 CHEMBL1965131 pKi 1000.0 nM
COc1cc(S(C)(=O)=O)c(OC)cc1CC(=O)Nc1cc(N)c(C#N)c(OC(C)C)n1 CHEMBL378627 pKi 1000.0 nM
O=C(Nc1cnc2[nH]cc(-c3ccccc3)c2c1)c1c(F)cccc1F CHEMBL1996979 pKi 1000.0 nM
Cc1cc(O)ccc1-n1cc(C(=O)NN)c(=O)c2ccc(-c3ccncc3)cc21 CHEMBL2000894 pKi 1000.0 nM
CNC(=O)C=Cc1cnc(N)c2c(-c3ccc4c(c3)OCO4)csc12 CHEMBL1993243 pKi 1000.0 nM
O=S(=O)(c1cccc2cnccc12)N1CCCNCC1 CHEMBL38380 pKi 1000.0 nM
O=C(Nc1cnccn1)Nc1ccnc2ccccc12 CHEMBL1981720 pKi 1000.0 nM
CC(N)COc1cnc(Cl)c(C=Cc2ccncc2)c1 CHEMBL1993548 pKi 1000.0 nM
CC(C)Nc1c(-c2ccc3[nH]ncc3c2)nc2ncccn12 CHEMBL1682553 pKi 1000.0 nM
COc1ccc(CN(C)C)cc1Nc1nccc(-c2c(-c3cccc(NC(=O)c4c(F)cccc4F)c3)nc3sccn23)n1 CHEMBL1997051 pKi 1000.0 nM
CC(C)Cc1cc(-c2ccc3[nH]nc(N)c3c2)on1 CHEMBL1966343 pKi 1000.0 nM
CC(Nc1cncc(-n2cnc3ccc(C#N)cc32)n1)c1ccccc1F CHEMBL1977138 pKi 1000.0 nM
NC(=O)Cn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL1985095 pKi 1000.0 nM
COc1cccc(OC)c1CNc1nc(NC2CCCCC2)nc2ccc(Cl)cc12 CHEMBL1996646 pKi 1000.0 nM
CC(C)c1nnc2ccc(-c3c(-c4ccc(F)cc4F)nc4occn34)nn12 CHEMBL1988995 pKi 1000.0 nM
Fc1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL316264 pKi 1000.0 nM
CCCCOc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1996817 pKi 1000.0 nM
Nc1ncc(C=CC(=O)NCCCn2ccnc2)c2scc(-c3ccc(Br)cc3)c12 CHEMBL1994938 pKi 1000.0 nM
CC(C)(CO)CNc1nccc(-c2c(-c3ccc(F)cc3)nc3cnccn23)n1 CHEMBL1991395 pKi 1000.0 nM
CC(C)(CO)c1nnc2ccc(-c3c(-c4ccc(F)cc4F)nc4occn34)nn12 CHEMBL1972849 pKi 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM