C[C@@H](CCCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1 CHEMBL3945327 EC50 1.4e-07 nM
C[C@@H](CCCCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1 CHEMBL3968443 EC50 2.7e-06 nM
CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1 CHEMBL251294 EC50 0.002 nM
C[C@@H](CCCc1ccccc1)[C@H](O)CC[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1 CHEMBL3900979 EC50 0.0029 nM
C[C@@H](CCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1 CHEMBL3975743 EC50 0.01 nM
O=C(O)CCCCCCN1C(=O)C(F)(F)C[C@@H]1/C=C/[C@@H](O)CCCCc1ccccc1 CHEMBL3959605 EC50 0.01 nM
COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCSCCCC(=O)O)c1 CHEMBL292964 EC50 0.01 nM
C[C@@H](CCCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1 CHEMBL3937596 EC50 0.0162 nM
O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)cc1 CHEMBL258332 Ki 0.02 nM
CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1 CHEMBL222715 EC50 0.02 nM
CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O CHEMBL548 EC50 0.02 nM
O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1ccccc1 CHEMBL5436415 EC50 0.02 nM
CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O CHEMBL3955128 EC50 0.021 nM
C[C@@H](CCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O CHEMBL3897335 EC50 0.023 nM
O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)cc1 CHEMBL272276 EC50 0.03 nM
CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCc1ccc(C(=O)O)cc1 CHEMBL3895047 EC50 0.035 nM
C[C@@H](Cc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1 CHEMBL3902065 EC50 0.038 nM
CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O CHEMBL3918816 EC50 0.038 nM
Cc1cc(Cl)ccc1-c1cccc([C@H](O)CC[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1 CHEMBL222677 EC50 0.04 nM
O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1 CHEMBL3974652 EC50 0.04 nM
CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O CHEMBL64804 EC50 0.05 nM
O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1 CHEMBL3906016 EC50 0.05 nM
O=C(CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1ccccc1)NS(=O)(=O)Cc1ccccc1 CHEMBL5395111 EC50 0.05 nM
C[C@@H](CCCCCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1 CHEMBL3893847 EC50 0.059 nM
CC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O CHEMBL3982139 EC50 0.059 nM
CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1 CHEMBL3916499 EC50 0.063 nM
CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O CHEMBL42027 EC50 0.065 nM
CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCc1ccc(C(=O)O)cc1 CHEMBL3923027 EC50 0.075 nM
CCCC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1 CHEMBL251505 EC50 0.1 nM
O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2cccc(Br)c2)cc1 CHEMBL249953 EC50 0.1 nM
CC1(C)C(=O)[C@H](SCCCSCC(=O)O)[C@@H](/C=C/C(O)CCc2sc3ccccc3c2Cl)[C@@H]1O CHEMBL3960625 EC50 0.1 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC3(NC(=O)NS(=O)(=O)c4ccc(C)cc4)CC3)cc1C)C2 CHEMBL1669013 Ki 0.11 nM
CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1 CHEMBL3949856 EC50 0.11 nM
CCOc1c2c(c(OCC)c3ncccc13)CN(c1ccc(CS(=O)(=O)NC(=O)Cc3c(OC)cccc3C(C)=O)cc1C)C2=O CHEMBL256873 Ki 0.12 nM
C[C@@H](CCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1 CHEMBL3891907 EC50 0.15 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC3(NC(=O)Cc4ncccc4OC)CC3)cc1C)C2 CHEMBL1669017 Ki 0.16 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC3(NC(=O)NS(=O)(=O)c4ccccc4Cl)CC3)cc1C)C2 CHEMBL1669012 Ki 0.16 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC3(NC(=O)NS(=O)(=O)c4ccccc4OC)CC3)cc1C)C2 CHEMBL1669009 Ki 0.17 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC3(NC(=O)Cc4cc(C(=O)O)ccc4OC)CC3)cc1C)C2 CHEMBL1669016 Ki 0.18 nM
O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)CCC2CCC2)cc1 CHEMBL222782 EC50 0.2 nM
O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(Cl)c2)cc1 CHEMBL249744 EC50 0.2 nM
O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(Br)c2)cc1 CHEMBL249538 EC50 0.2 nM
C[C@H](NC(=O)c1cccc2c1N(Cc1cccc(C(F)(F)F)c1)CC2)c1ccc(C(=O)O)cc1 CHEMBL1645138 EC50 0.2 nM
COc1ccccc1CC(=O)NCCc1ccc(-c2c(C(=O)N(C)C)sc3c(C)cc(C)cc23)cc1 CHEMBL1644016 Ki 0.2 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC3(NC(=O)Cc4ccccc4OC)CC3)cc1C)C2 CHEMBL1669018 Ki 0.2 nM
CCCCC[C@H](O)/C=C/[C@@H]1[C@@H](C/C=C\CCCC(=O)O)C(=O)C(C)(C)[C@H]1O CHEMBL3895324 EC50 0.2 nM
O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1 CHEMBL3978590 EC50 0.2 nM
O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1 CHEMBL3892492 EC50 0.2 nM
O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1 CHEMBL3981554 EC50 0.2 nM
O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1 CHEMBL3900245 EC50 0.2 nM
CCOc1c2c(c(OCC)c3ncccc13)CN(c1ccc(CS(=O)(=O)NC(=O)Cc3ccccc3OC(F)(F)F)cc1C)C2=O CHEMBL269987 Ki 0.21 nM
CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O CHEMBL62570 EC50 0.22 nM
O=C(O)c1ccc(C2(NC(=O)c3cccc4ccn(Cc5ccc(C(F)(F)F)cc5)c34)CC2)cc1 CHEMBL1084009 Ki 0.23 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC3(NC(=O)NS(=O)(=O)c4ccccc4C)CC3)cc1C)C2 CHEMBL1669010 Ki 0.23 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CS(=O)(=O)NC(=O)Cc3ccccc3)cc1C)C2 CHEMBL255527 Ki 0.25 nM
CCOc1ccccc1CC(=O)NS(=O)(=O)Cc1ccc(N2Cc3c(c(OCC)c4cccnc4c3OCC)C2=O)c(C)c1 CHEMBL255906 Ki 0.27 nM
CCOc1c2c(c(OCC)c3ncccc13)CN(c1ccc(CS(=O)(=O)NC(=O)Cc3ccccc3Cl)cc1C)C2=O CHEMBL218699 Ki 0.27 nM
CCOc1c2c(c(OCC)c3ncccc13)CN(c1ccc(CS(=O)(=O)NC(=O)Cc3c(Cl)cccc3Cl)cc1C)C2=O CHEMBL272363 Ki 0.28 nM
C[C@H](NC(=O)c1cccc2c1N(Cc1ccc(-c3ccccc3)cc1)CC2)c1ccc(C(=O)O)cc1 CHEMBL1645141 Ki 0.28 nM
Cc1ccc(-c2cccc(CO)c2)cc1C(=O)Nc1c(C)cc(C(=O)O)cc1C CHEMBL3753860 IC50 0.28 nM
O=C(NS(=O)(=O)Cc1ccccc1)c1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 CHEMBL191638 Ki 0.3 nM
CCCCC1([C@@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1 CHEMBL272277 EC50 0.3 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC3(NC(=O)NS(=O)(=O)c4c(Cl)cccc4Cl)CC3)cc1C)C2 CHEMBL1669008 Ki 0.3 nM
Cc1ccccc1S(=O)(=O)NC(=O)c1cc(CNc2ccc(-c3ccc(OC(F)F)cc3)cc2)c(C)o1 CHEMBL3260768 Ki 0.3 nM
CC1(C)C(=O)[C@H](C/C=C\CCCC(=O)O)[C@@H](/C=C/C(O)CCc2sc3ccccc3c2Cl)[C@@H]1O CHEMBL3955476 EC50 0.3 nM
CC1(C)C(=O)[C@H](C/C=C\CCCC(=O)O)[C@@H](/C=C/C(O)Cc2cc3ccccc3s2)[C@@H]1O CHEMBL3922155 EC50 0.3 nM
O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1 CHEMBL3904946 EC50 0.3 nM
O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1 CHEMBL3976710 EC50 0.3 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CS(=O)(=O)NC(=O)Cc3ccccc3)cc1)C2 CHEMBL255422 Ki 0.31 nM
O=C(O)c1ccc(C2(NC(=O)c3cc(Cl)cc4ccn(Cc5ccc(C(F)(F)F)cc5)c34)CC2)cc1 CHEMBL1086490 Ki 0.31 nM
CCOc1c2c(c(OCC)c3ncccc13)CN(c1ccc(CS(=O)(=O)NC(=O)Cc3ccccc3OC(F)F)cc1C)C2=O CHEMBL257255 Ki 0.32 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CCNC(=O)Cc3ccccc3OC)cc1C)C2 CHEMBL1669023 Ki 0.32 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC3(NC(=O)Cc4ccccc4Cl)CC3)cc1C)C2 CHEMBL1669015 Ki 0.32 nM
C[C@H](NC(=O)c1cccc2c1N(Cc1cc(Br)cc(Br)c1)CC2)c1ccc(C(=O)O)cc1 CHEMBL1645142 Ki 0.33 nM
COc1ccccc1C1(C(=O)NS(=O)(=O)Cc2ccc(-c3c(C(=O)N(C)C)sc4c(C)cc(C)cc34)cc2)CC1 CHEMBL1644006 Ki 0.33 nM
C[C@H](NC(=O)c1cccc2c1N(Cc1ccc(Cl)c(Cl)c1)CC2)c1ccc(C(=O)O)cc1 CHEMBL1645134 Ki 0.34 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC3(NC(=O)Cc4ccc(Cl)cc4Cl)CC3)cc1C)C2 CHEMBL1669014 Ki 0.34 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC3(NC(=O)NS(=O)(=O)c4c(OC)cccc4OC)CC3)cc1C)C2 CHEMBL1669005 Ki 0.34 nM
COc1ccccc1CC(=O)NS(=O)(=O)Cc1ccc(N2Cc3c(c(OC(C)C)c4cccnc4c3OC(C)C)C2=O)c(C)c1 CHEMBL272498 Ki 0.36 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CS(=O)(=O)NC(=O)Cc3cc(OC)ccc3OC)cc1)C2 CHEMBL256220 Ki 0.37 nM
C[C@H](NC(=O)c1cccc2c1N(Cc1ccc(C(F)(F)F)cc1)CC2)c1ccc(C(=O)O)cc1 CHEMBL1645137 Ki 0.37 nM
C[C@H](NC(=O)c1cc(F)cc2c1N(Cc1ccc(C(F)(F)F)cc1)CC2)c1ccc(C(=O)O)cc1 CHEMBL1645155 Ki 0.37 nM
C[C@@H](CCCCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1 CHEMBL3977939 EC50 0.37 nM
COc1ccccc1CC(=O)NS(=O)(=O)Cc1ccc(N2Cc3c(c(OCC(F)(F)F)c4cccnc4c3OCC(F)(F)F)C2=O)c(C)c1 CHEMBL271095 Ki 0.38 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CS(=O)(=O)NC(=O)COc3ccccc3)cc1)C2 CHEMBL256183 Ki 0.38 nM
C[C@H](NC(=O)c1cccc2ccn(Cc3cc(Cl)cc(OC(F)(F)F)c3)c12)c1ccc(C(=O)O)cc1 CHEMBL1084552 Ki 0.38 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC3(NC(=O)NS(=O)(=O)c4ccccc4C(F)(F)F)CC3)cc1C)C2 CHEMBL1669006 Ki 0.39 nM
C[C@H](NC(=O)c1cc(Cl)cc2c1N(Cc1ccc(C(F)(F)F)cc1)CC2)c1ccc(C(=O)O)cc1 CHEMBL1645153 Ki 0.4 nM
Cc1cc(C)c2sc(C(=O)N(C)C)c(-c3ccc(CCNC(=O)NS(=O)(=O)c4ccc(Cl)cc4)cc3)c2c1 CHEMBL1644004 Ki 0.4 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC3(NC(=O)NS(=O)(=O)c4cccc(Cl)c4Cl)CC3)cc1C)C2 CHEMBL1669025 Ki 0.4 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC3(NC(=O)NS(=O)(=O)c4c(C)cccc4C)CC3)cc1C)C2 CHEMBL1669026 Ki 0.4 nM
CC1(C)C(=O)[C@H](C/C=C\CCCC(=O)O)[C@@H](/C=C/C(O)Cc2ccccc2)[C@@H]1O CHEMBL3964563 EC50 0.4 nM
C/C=C/c1nnn(Cc2ccc(C(F)(F)F)cc2)c1C(=O)N[C@@H](C)c1ccc(C(=O)O)cc1 CHEMBL4535971 IC50 0.4 nM
Cc1ccc(Cc2sc3c(c2C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)CCOC3)cc1 CHEMBL5186935 IC50 0.4 nM
Cc1ccc(S(=O)(=O)NC(=O)NCCc2ccc(-c3c(C(=O)N4CCCC4)sc4c(C)cc(C)cc34)cc2)cc1 CHEMBL1644010 Ki 0.41 nM
Cc1cc(C)c2sc(C(=O)N(C)C)c(-c3ccc(CCNC(=O)NS(=O)(=O)c4ccccc4Cl)cc3)c2c1 CHEMBL1644005 Ki 0.42 nM
CCOc1c2c(c(OCC)c3ncccc13)CN(c1ccc(CS(=O)(=O)NC(=O)Cc3ccccc3C(F)(F)F)cc1C)C2=O CHEMBL270397 Ki 0.43 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CS(=O)(=O)NC(=O)Cc3cccc4ccccc34)cc1)C2 CHEMBL255529 Ki 0.43 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CS(=O)(=O)NC(=O)Cc3c(C)cc(C)cc3C)cc1)C2 CHEMBL271070 Ki 0.43 nM
C[C@H](NC(=O)c1cc(Cl)cc2ccn(Cc3ccc(C(F)(F)F)cc3)c12)c1ccc(C(=O)O)cc1 CHEMBL1083400 Ki 0.44 nM
C[C@H](NC(=O)c1cccc2c1N(Cc1cccc(Cl)c1)CC2)c1ccc(C(=O)O)cc1 CHEMBL1645133 Ki 0.44 nM
C[C@H](NC(=O)c1cccc2c1N(Cc1ccc(Cl)cc1)CC2)c1ccc(C(=O)O)cc1 CHEMBL1645135 Ki 0.44 nM
Cc1cc(C)c2sc(C(=O)N(C)C)c(-c3ccc(CS(=O)(=O)NC(=O)C4(c5c(Cl)cccc5Cl)CC4)cc3)c2c1 CHEMBL1644007 Ki 0.44 nM
CC(C)[C@@H](OCCOc1ccccc1)C(=O)N[C@@H](C)c1ccc(C(=O)O)cc1 CHEMBL3667607 Ki 0.45 nM
C[C@H](NC(=O)c1c(Br)sc(Br)c1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1 CHEMBL3695937 Ki 0.47 nM
CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O CHEMBL4558749 EC50 0.476 nM
CCOc1c2c(c(OCC)c3ncccc13)CN(c1ccc(CS(=O)(=O)NC(=O)Cc3ccccc3F)cc1C)C2=O CHEMBL402960 Ki 0.48 nM
Cc1cc(CC2(NC(=O)NS(=O)(=O)c3ccccc3Cl)CC2)ccc1N1Cc2c(c(OCC(F)(F)F)c3cccnc3c2OCC(F)(F)F)C1=O CHEMBL1669011 Ki 0.48 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC3(NC(=O)NS(=O)(=O)c4ccc(F)cc4)CC3)cc1C)C2 CHEMBL1669024 Ki 0.48 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC3(NC(=O)NS(=O)(=O)c4ccccc4Br)CC3)cc1C)C2 CHEMBL1669004 Ki 0.49 nM
C/C(=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1)c1ccccc1 CHEMBL248679 EC50 0.5 nM
CNC(=O)c1sc2c(C)cc(C)cc2c1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1 CHEMBL1644009 Ki 0.5 nM
O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1 CHEMBL1933725 EC50 0.5 nM
Cc1sc(C)c(C(=O)NC2(c3ccc(C(=O)O)cc3)CC2)c1Cc1ccc(C(F)(F)F)cc1 CHEMBL597997 Ki 0.5 nM
O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc3ccsc3c2)cc1 CHEMBL3965850 EC50 0.5 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC3(NC(=O)NS(=O)(=O)c4ccc5ccccc5c4)CC3)cc1C)C2 CHEMBL1669007 Ki 0.52 nM
Cc1ccc(S(=O)(=O)NC(=O)NCCc2ccc(-c3c(C(=O)N(C)C)sc4c(F)cc(F)cc34)cc2)cc1 CHEMBL1644012 Ki 0.53 nM
CCOc1c2c(c(OCC)c3ncccc13)CN(c1ccc(CS(=O)(=O)NC(=O)C3(c4c(OC)cccc4OC)CC3)cc1C)C2=O CHEMBL405446 Ki 0.54 nM
Cc1ccc(S(=O)(=O)NC(=O)NCCc2ccc(-c3c(C(=O)N(C)C)sc4c(C)cc(C)cc34)cc2)cc1 CHEMBL1644003 Ki 0.54 nM
CCOc1c2c(c(OCC)c3ncccc13)CN(c1ccc(CS(=O)(=O)NC(=O)C3(c4ccccc4OC)CC3)cc1C)C2=O CHEMBL256822 Ki 0.55 nM
Cc1ccc(S(=O)(=O)NC(=O)NCCc2ccc(-c3c(C(=O)N(C)C)sc4c(Cl)cc(C(F)(F)F)cc34)cc2)cc1 CHEMBL1644013 Ki 0.55 nM
Cc1ccc(S(=O)(=O)NC(=O)NCCc2ccc(-c3c(C(=O)N(C)C)sc4c(Cl)cc(Cl)cc34)cc2)cc1 CHEMBL1644011 Ki 0.59 nM
Cc1noc(C)c1S(=O)(=O)NC(=O)c1cc(COc2ccc(-c3ccc(OC(F)F)cc3)cc2)c(C)o1 CHEMBL3260767 Ki 0.6 nM
Cc1sc(C)c(C(=O)NC2(c3ccc(-c4nn[nH]n4)cc3)CC2)c1Cc1ccc(C(F)(F)F)cc1 CHEMBL598198 Ki 0.6 nM
C[C@H](NC(=O)c1cccc2ccn(Cc3ccc(C(F)(F)F)cc3)c12)c1ccc(C(=O)O)cc1 CHEMBL1084553 Ki 0.62 nM
C[C@H](NC(=O)c1cc(C(F)(F)F)cc2c1N(Cc1ccc(C(F)(F)F)cc1)CC2)c1ccc(C(=O)O)cc1 CHEMBL1645154 Ki 0.66 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC3(NC(=O)NS(=O)(=O)c4ccc(OC(F)(F)F)cc4)CC3)cc1C)C2 CHEMBL1669002 Ki 0.66 nM
CCOc1c2c(c(OCC)c3ncccc13)CN(c1ccc(CC(C)NC(=O)Cc3ccccc3OC)cc1C)C2=O CHEMBL1669019 Ki 0.67 nM
Cc1ccc(-c2cccc(CO)c2)nc1C(=O)Nc1c(C)cc(C(=O)O)cc1C CHEMBL3753835 IC50 0.67 nM
Cc1cc(C(=O)O)cc(C)c1NC(=O)c1nc(-c2cccc(CO)c2)ccc1C(F)(F)F CHEMBL3752948 IC50 0.67 nM
O=C(NOCc1ccccc1)c1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 CHEMBL371394 Ki 0.68 nM
COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1 CHEMBL222834 Ki 0.7 nM
Cc1sc(C)c(C(=O)NC2(c3ccc(-c4nn[nH]n4)cc3)CC2)c1Cc1cccc(C(F)(F)F)c1 CHEMBL3695945 Ki 0.7 nM
COc1ccccc1CC(=O)NCCc1ccc(N2Cc3c(c(OC(F)F)c4ccccc4c3OC(F)F)C2=O)c(C)c1 CHEMBL1669022 Ki 0.71 nM
C[C@H](NC(=O)c1csc(Br)c1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1 CHEMBL3695936 Ki 0.71 nM
O=C(O)c1ccc(CNC(=O)c2c(Cl)sc(Cl)c2Cc2cccc(Cl)c2)cc1 CHEMBL601299 Ki 0.72 nM
Cc1cc(C(=O)O)cc(C)c1NC(=O)c1cc(-c2cccc(CO)c2)ccc1F CHEMBL3753567 IC50 0.73 nM
CCOc1c2c(c(OCC)c3ncccc13)CN(c1ccc(CS(=O)(=O)NC(=O)Cc3ccccc3OC)cc1C)C2=O CHEMBL402162 Ki 0.74 nM
Cc1sc(C)c(C(=O)NC2(c3ccc(C(=O)O)cc3)CC2)c1Cc1cccc(C(F)(F)F)c1 CHEMBL603462 Ki 0.75 nM
CCOc1c2c(c(OCC)c3ncccc13)CN(c1ccc(CS(=O)(=O)NC(=O)Cc3ccccc3)cc1C)C2=O CHEMBL403630 Ki 0.76 nM
Cc1ccc(S(=O)(=O)NC(=O)NCCc2ccc(-c3c(C(=O)N(C)C)sc4c(C)ccc(C)c34)cc2)cc1 CHEMBL1644014 Ki 0.77 nM
Cc1ccc(CN2CCc3cccc(C(=O)N[C@@H](C)c4ccc(C(=O)O)cc4)c32)cc1 CHEMBL1645148 Ki 0.78 nM
COc1cccc(OC)c1C1(C(=O)NS(=O)(=O)Cc2ccc(N3Cc4c(c(OCC(F)(F)F)c5cccnc5c4OCC(F)(F)F)C3=O)c(C)c2)CC1 CHEMBL404199 Ki 0.79 nM
CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)N1C/C=C/CCCC(=O)O CHEMBL413509 Ki 0.8 nM
Cc1cc(Cl)ccc1-c1cccc(C(O)/C=C/[C@H]2CCC(=O)N2CCCCCCC(=O)O)c1 CHEMBL298026 EC50 0.8 nM
C[C@H](NC(=O)c1c(Cl)sc(Cl)c1Cc1cccc(C(F)(F)F)c1)c1ccc(C(=O)O)cc1 CHEMBL3695943 Ki 0.8 nM
O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc3ccccc3c2)cc1 CHEMBL3958395 Ki 0.8 nM
C[C@H](NC(=O)c1cc(Cl)cc2ccn(Cc3cccc(Cl)c3)c12)c1ccc(C(=O)O)cc1 CHEMBL1085040 Ki 0.81 nM
O=C(O)c1ccc(CNC(=O)c2c3ccccc3nn2Cc2ccc(C(F)(F)F)cc2)cc1 CHEMBL5431224 pA2 0.863 nM
C[C@@H](NC(=O)c1c(Cl)sc(Cl)c1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1 CHEMBL591431 Ki 0.87 nM
CCOc1c2c(c(OCC)c3ncccc13)CN(c1ccc(CCNC(=O)Cc3ccccc3OC)cc1C)C2=O CHEMBL1669020 Ki 0.87 nM
O=C(O)CCCCCNC(=O)[C@H](CCCNC(=O)OCc1ccccc1)NC(=O)c1cc2ccccc2o1 CHEMBL192729 Ki 0.91 nM
COc1ccccc1C1(C(=O)NS(=O)(=O)Cc2ccc(N3Cc4c(c(OCC(F)(F)F)c5cccnc5c4OCC(F)(F)F)C3=O)c(C)c2)CC1 CHEMBL270223 Ki 0.95 nM
COC(=O)c1sc2c(C)cc(C)cc2c1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1 CHEMBL1644002 Ki 0.97 nM
C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1 CHEMBL4099851 Ki 0.97 nM
Cc1cc(C)c2sc(C(=O)N(C)C)c(-c3ccc(CCNc4ncccn4)cc3)c2c1 CHEMBL1644020 Ki 0.98 nM
CCCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1 CHEMBL257217 Ki 1.0 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CS(=O)(=O)NC(=O)C3CCCc4ccccc43)cc1)C2 CHEMBL401795 Ki 1.0 nM
C[C@H](NC(=O)c1cccc2c1N(Cc1ccc(C(F)(F)F)cc1)CC2)c1ccc(-c2nn[nH]n2)cc1 CHEMBL1645152 Ki 1.0 nM
O=C(O)c1ccc(CCCN2[C@@H](/C=C/C(O)Cc3cccc(OC(F)(F)F)c3)CCS2(=O)=O)s1 CHEMBL3965497 EC50 1.0 nM
C[C@H](NC(=O)c1c(Cc2ccc(Cl)cc2)sc2c1CCOC2)c1ccc(C(=O)O)cc1 CHEMBL5171006 IC50 1.0 nM
O=C(O)c1ccc(C2(NC(=O)c3c(Cc4cccc(C(F)(F)F)c4)sc4c3CCOC4)CC2)cc1 CHEMBL5204626 IC50 1.0 nM
Cc1cc(C)c2sc(C(=O)N(C)C)c(-c3ccc(Cc4nn[nH]n4)cc3)c2c1 CHEMBL1643998 Ki 1.1 nM
Cc1cc(C(=O)O)cc(C)c1NC(=O)c1cc(-c2cccc(CO)c2)cc2ccccc12 CHEMBL3741430 IC50 1.11 nM
O=C1CC[C@H](/C=C/[C@@H](O)Cc2ccccc2)N1CCCCCCc1nnn[nH]1 CHEMBL275667 Ki 1.2 nM
Cc1cc(CC2(NC(=O)NS(=O)(=O)c3ccc4ccccc4c3)CC2)ccc1N1Cc2c(c(OCC(F)(F)F)c3cccnc3c2OCC(F)(F)F)C1=O CHEMBL1669003 Ki 1.2 nM
C[C@H](NC(=O)c1cc(Cl)ccc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1 CHEMBL4078648 pA2 1.259 nM
C[C@H](NC(=O)c1c(Cl)sc(Cl)c1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1 CHEMBL599052 Ki 1.3 nM
Cc1oc(C(=O)NS(=O)(=O)c2ccccc2)cc1COc1ccc(-c2ccc(OC(F)F)cc2)cc1 CHEMBL3260457 Ki 1.3 nM
COc1ccc(-c2ccc(OCc3cc(C(=O)NS(=O)(=O)c4c(C)noc4C)oc3C)cc2)cc1 CHEMBL3260463 Ki 1.3 nM
C[C@H](NC(=O)c1c(-c2ccccc2)nnn1CCOc1cccc(C(F)(F)F)c1)c1ccc(C(=O)O)cc1 CHEMBL4457944 IC50 1.3 nM
Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1ccc(C(F)(F)F)cc1 CHEMBL603690 Ki 1.4 nM
COc1ccc(/C=C/C(=O)NCCc2c(C)[nH]c3ccccc23)cc1OC CHEMBL3264208 Kb 1.46 nM
C[C@H](NC(=O)c1cccc2c1N(Cc1ccc(OC(F)(F)F)cc1)CC2)c1ccc(C(=O)O)cc1 CHEMBL1645139 Ki 1.5 nM
Cc1ccc(-c2cccc(Cl)c2)nc1C(=O)Nc1c(C)ccc(C(=O)O)c1C CHEMBL3753372 IC50 1.56 nM
O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(C(F)(F)F)c1 CHEMBL45008 Ki 1.6 nM
Cc1cc(C)c2sc(C(=O)N(C)C)c(-c3ccc(CCNC(=O)Cc4c(Cl)cccc4Cl)cc3)c2c1 CHEMBL1644019 Ki 1.6 nM
Cc1ccc(N2CCC(F)(F)CC2)nc1C(=O)Nc1c(C)cc(C(=O)O)cc1C CHEMBL3793002 IC50 1.61 nM
C[C@H](NC(=O)c1c(Cc2cccc(C(F)(F)F)c2)sc2c1CCOC2)c1ccc(C(=O)O)cc1 CHEMBL5189703 IC50 1.7 nM
O=C(O)c1ccc(CNC(=O)c2c3ccccc3nn2Cc2ccc(Cl)c(F)c2)cc1 CHEMBL5427544 IC50 1.7 nM
C[C@H](NC(=O)c1cc(Cl)ccc1Oc1ccc(F)cc1)c1ccc(C(=O)O)cc1 CHEMBL591666 pA2 1.778 nM
C[C@H](NC(=O)c1cccc2c1N(Cc1ccc(F)cc1)CC2)c1ccc(C(=O)O)cc1 CHEMBL1645136 Ki 1.8 nM
C[C@H](NC(=O)c1c(Cl)sc(Cl)c1C(O)c1cccc(Cl)c1)c1ccc(C(=O)O)cc1 CHEMBL3695940 Ki 1.8 nM
O=C(O)c1ccc(CNC(=O)c2c3ccccc3nn2Cc2ccc(C(F)(F)F)c(F)c2)cc1 CHEMBL5394484 IC50 1.8 nM
COC(=O)c1sc2c(C)cc(C)cc2c1-c1ccc(Cc2nn[nH]n2)cc1 CHEMBL1643997 Ki 1.9 nM
COc1cccc(Cc2sc3c(c2C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)CCOC3)c1 CHEMBL5192663 IC50 1.9 nM
COc1ccc(Cc2sc3c(c2C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)CCOC3)cc1F CHEMBL5179874 IC50 1.9 nM
Cc1ccc(C(=O)O)c(C)c1NC(=O)c1nc(-c2cccc(CO)c2)ccc1C(F)(F)F CHEMBL3753286 IC50 1.94 nM
Cc1ccc(C(=O)O)c(C)c1NC(=O)c1cc(-c2cccc(CO)c2)cc2ccccc12 CHEMBL3740223 Ki 1.98 nM
CCCC/C=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1 CHEMBL251709 EC50 2.0 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CS(=O)(=O)NC(=O)Cn3nccc3C)cc1)C2 CHEMBL403492 Ki 2.0 nM
C[C@H](NC(=O)c1cccc2c1Oc1cc(C(F)(F)F)ccc1CC2)c1ccc(C(=O)O)cc1 CHEMBL1910022 IC50 2.0 nM
Cc1ccccc1S(=O)(=O)NC(=O)c1cc(CNc2ccc(-c3ccccc3)cc2)c(C)o1 CHEMBL3260766 Ki 2.0 nM
O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Cl)c2)cc1 CHEMBL3902700 EC50 2.0 nM
COc1ccc2ccc(CC(O)/C=C/[C@H]3CCC(=O)[C@@H]3CCc3ccc(C(=O)O)cc3)cc2c1 CHEMBL3919302 EC50 2.0 nM
CC(C)CC(=O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(C(F)(F)F)c2)s1 CHEMBL5272661 IC50 2.0 nM
O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(C(F)(F)F)c2)s1 CHEMBL378376 IC50 2.0 nM
O=C(O)c1ccc(CNC(=O)c2c3ccccc3nn2Cc2ccc(OC(F)(F)F)cc2)cc1 CHEMBL5427672 IC50 2.0 nM
O=C(O)c1ccc(CNC(=O)c2c3ccccc3nn2Cc2ccc(C(F)(F)F)cc2F)cc1 CHEMBL5428393 IC50 2.0 nM
C[C@H](NC(=O)c1c(Cc2ccc(C(F)(F)F)cc2)sc2c1CCOC2)c1ccc(C(=O)O)cc1 CHEMBL5208220 IC50 2.1 nM
COc1ccc(Cc2sc3c(c2C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)CCOC3)cc1 CHEMBL5205440 IC50 2.1 nM
CC(C)c1ccc(Cn2nc3ccccc3c2C(=O)NCc2ccc(C(=O)O)cc2)cc1 CHEMBL5436396 IC50 2.1 nM
COc1ccc(Cn2nc3ccccc3c2C(=O)NCc2ccc(C(=O)O)cc2)cc1F CHEMBL5408721 IC50 2.1 nM
C[C@H](NC(=O)c1cccc2c1N(Cc1ccc(Cl)cc1Br)CC2)c1ccc(C(=O)O)cc1 CHEMBL1645144 Ki 2.3 nM
Cc1cc(C)c2sc(C(=O)N(C)C)c(-c3ccc(CCNC(=O)Cc4ccccn4)cc3)c2c1 CHEMBL1644017 Ki 2.3 nM
Cc1ccc(-c2cccc(CO)c2)cc1C(=O)Nc1c(C)ccc(C(=O)O)c1C CHEMBL3753274 IC50 2.31 nM
Cc1ccc(-c2cccc(CO)c2)nc1C(=O)Nc1c(C)ccc(C(=O)O)c1C CHEMBL3754085 IC50 2.36 nM
CCOc1c2c(c(OCC)c3ncccc13)CN(c1ccc(CS(=O)(=O)NC(=O)Cc3ccccn3)cc1C)C2=O CHEMBL257886 Ki 2.4 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CS(=O)(=O)NC(=O)Cc3cccc(OC)c3)cc1)C2 CHEMBL404440 Ki 2.4 nM
C[C@H](NC(=O)c1cc(F)cc2ccn(Cc3cccc(Cl)c3)c12)c1ccc(C(=O)O)cc1 CHEMBL1085041 Ki 2.4 nM
Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1cccc(C(F)(F)F)c1 CHEMBL605330 Ki 2.4 nM
O=C(O)c1ccc(CNC(=O)c2c3ccccc3nn2Cc2ccc(Cl)cc2)cc1 CHEMBL5420529 IC50 2.4 nM
C[C@H](NC(=O)c1cc(Cl)cnc1Oc1ccc(F)cc1)c1ccc(C(=O)O)cc1 CHEMBL4096216 pA2 2.455 nM
O=C1CC[C@H](/C=C/[C@@H](O)Cc2ccccc2)N1CCCCCCc1nnn[nH]1 CHEMBL1794823 Ki 2.5 nM
C[C@H](NC(=O)c1c(Cc2cc(F)c(Cl)cc2Cl)sc2c1CCOC2)c1ccc(C(=O)O)cc1 CHEMBL5196679 IC50 2.5 nM
O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)Cc1ccccc1 CHEMBL14359 Ki 2.6 nM
CC(NC(=O)c1sc(Cl)cc1Cc1cccc(Cl)c1)c1ccc(-c2nn[nH]n2)cc1 CHEMBL3695935 Ki 2.6 nM
C[C@H](NC(=O)c1cccc2ccn(Cc3cccc(Cl)c3)c12)c1ccc(C(=O)O)cc1 CHEMBL1085081 Ki 2.7 nM
CC(C)c1ccc(Cc2sc3c(c2C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)CCOC3)cc1 CHEMBL5204873 IC50 2.7 nM
O=C(O)c1ccc(CNC(=O)c2c(Cc3ccc(F)cc3)sc3c2CCOC3)cc1 CHEMBL5186525 IC50 2.7 nM
CCOc1c2c(c(OCC)c3ncccc13)CN(c1ccc(CS(=O)(=O)NC(=O)Cc3cccnc3)cc1C)C2=O CHEMBL444800 Ki 2.8 nM
C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccc(F)cc1)c1ccc(C(=O)O)cc1 CHEMBL3600884 IC50 2.87 nM
Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1ccc(Cl)cc1 CHEMBL599262 Ki 2.9 nM
CS(=O)(=O)NC(=O)CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1ccccc1 CHEMBL5411667 EC50 2.9 nM
CC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1 CHEMBL251710 EC50 3.0 nM
CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1 CHEMBL257658 EC50 3.0 nM
COc1ccccc1C1(C(=O)NCCc2ccc(-c3c(C(=O)N(C)C)sc4c(C)cc(C)cc34)cc2)CC1 CHEMBL1644018 Ki 3.0 nM
COc1ccc(-c2ccc(OCc3cc(C(=O)NS(=O)(=O)Cc4ccccc4)oc3C)cc2)cc1 CHEMBL3260758 Ki 3.0 nM
COc1ccc(-c2ccc(OCc3cc(C(=O)NS(=O)(=O)c4ccccc4C)oc3C)cc2)nc1 CHEMBL1628698 Ki 3.0 nM
COc1ccc(-c2ccc(OCc3cc(C(=O)[N-]S(=O)(=O)c4ccccc4C)oc3C)cc2)nc1 CHEMBL3260771 Ki 3.0 nM
CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1 CHEMBL3754586 EC50 3.0 nM
O=C(CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1ccccc1)NS(=O)(=O)c1ccccc1 CHEMBL5410348 EC50 3.0 nM
Cc1cc(C(=O)O)cc(C)c1NC(=O)c1cc(-c2cccc(CO)c2)nc2ccccc12 CHEMBL3739779 IC50 3.08 nM
Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1cccc(Cl)c1 CHEMBL604546 Ki 3.1 nM
C[C@H](NC(=O)c1cccc2c1N(Cc1ccc(C#N)cc1)CC2)c1ccc(C(=O)O)cc1 CHEMBL1645140 Ki 3.1 nM
C[C@H](NC(=O)c1c(-c2ccccc2)nnn1CCOc1ccc(F)cc1)c1ccc(C(=O)O)cc1 CHEMBL4439228 IC50 3.1 nM
C[C@H](NC(=O)c1c(Cc2cccc(Cl)c2)sc2c1CCOC2)c1ccc(C(=O)O)cc1 CHEMBL5195791 IC50 3.2 nM
CCOc1c2c(c(OCC)c3ncccc13)C(=O)N(c1ccc(CS(=O)(=O)NC(=O)Cc3ccccc3)cc1C)C2 CHEMBL256005 Ki 3.3 nM
O=C(O)c1ccc(C2(NC(=O)c3c(Cc4ccc(F)cc4)sc4c3CCOC4)CC2)cc1 CHEMBL5181946 IC50 3.4 nM
O=C(O)c1ccc(CNC(=O)c2c(Cc3cccc(C(F)(F)F)c3)sc3c2CCOC3)cc1 CHEMBL5177678 IC50 3.4 nM
Cc1cc(C(=O)O)cc(C)c1NC(=O)c1cc(-c2ccccc2)cc2ccccc12 CHEMBL3742015 IC50 3.48 nM
Cc1ccc(C(=O)O)c(C)c1NC(=O)c1cc(-c2cccc(Cl)c2)cc2ccccc12 CHEMBL3740325 Ki 3.49 nM
Cc1cc(/C=C/C(=O)NCCc2c(C)[nH]c3ccccc23)cc(C)c1F CHEMBL3264210 Kb 3.5 nM
COCc1cccc(CC(O)/C=C/[C@H]2CCC(=O)N2CCCCCCC(=O)O)c1 CHEMBL275245 Ki 3.6 nM
COc1ccc(-c2ccc(OCc3cc(C(=O)NS(=O)(=O)c4cccs4)oc3C)cc2)cc1 CHEMBL3260757 Ki 3.6 nM
O=C(O)c1ccc(CNC(=O)c2c3ccccc3nn2Cc2ccc(F)c(Cl)c2)cc1 CHEMBL5402938 IC50 3.7 nM
CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O CHEMBL223151 Ki 3.8 nM
Cc1ccc(S(=O)(=O)NC(=O)NCCc2ccc(-c3c(C(N)=O)sc4c(C)cc(C)cc34)cc2)cc1 CHEMBL1644008 Ki 3.8 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC(=O)O)cc1F)C2 CHEMBL4225243 pEC50 3.981 nM
CC(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1 CHEMBL398947 EC50 4.0 nM
O=C(O)c1ccc(C2(NC(=O)c3cccc4c3Oc3cc(C(F)(F)F)ccc3CC4)CC2)cc1 CHEMBL1910023 IC50 4.0 nM
O=C(O)c1ccc(C2(NC(=O)C3CC4(CCN3Cc3cccc(C(F)(F)F)c3)CC4)CC2)cc1 CHEMBL3896466 IC50 4.0 nM
O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)CC1CCC1 CHEMBL416262 Ki 4.2 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CS(=O)(=O)NC(=O)CCc3ccsc3)cc1)C2 CHEMBL255632 Ki 4.2 nM
CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1 CHEMBL3752377 EC50 4.2 nM
CCn1c2ccc(-c3nc4c(C)c(C(=O)O)ccc4n3CCOC)cc2c2cccc(C)c21 CHEMBL4520937 IC50 4.2 nM
Cc1ccc(Cn2nc3ccccc3c2C(=O)NCc2ccc(C(=O)O)cc2)cc1 CHEMBL5410514 IC50 4.2 nM
COc1cc(/C=C/C(=O)NCCc2c(C)[nH]c3ccccc23)cc(OC)c1OC CHEMBL3264207 Kb 4.3 nM
CCn1c2ccccc2c2cc(-c3nc4c(F)c(C(=O)O)ccc4n3CCOC)ccc21 CHEMBL4548693 IC50 4.3 nM
C[C@H](NC(=O)c1c(Nc2cccc(C(F)(F)F)c2)c2ccccc2n1C)c1ccc(C(=O)O)cc1 CHEMBL5418164 IC50 4.3 nM
C[C@H](NC(=O)c1c2ccccc2nn1Cc1ccc(OC(F)(F)F)cc1)c1ccc(C(=O)O)cc1 CHEMBL5413066 IC50 4.3 nM
COc1ccccc1CC(=O)NCCc1ccc(N2Cc3c(c(OCC(F)(F)F)c4ccccc4c3OCC(F)(F)F)C2=O)c(C)c1 CHEMBL1669021 Ki 4.4 nM
CCn1c2ccc(Cl)cc2c2cc(-c3nc4c(C)c(C(=O)O)ccc4n3CCOC)ccc21 CHEMBL4516303 IC50 4.4 nM
COc1ccc(Cn2nc3ccccc3c2C(=O)NCc2ccc(C(=O)O)cc2)cc1 CHEMBL5426459 IC50 4.4 nM
Cc1ccc(C(=O)O)c(C)c1NC(=O)c1cc(-c2cccc(CO)c2)ccc1F CHEMBL3753133 IC50 4.49 nM
C[C@H](NC(=O)c1c(Cc2ccc(F)cc2)sc2c1CCOC2)c1ccc(C(=O)O)cc1 CHEMBL5176688 IC50 4.5 nM
C[C@H](NC(=O)c1c(C(F)F)nn(C)c1Oc1cccc(C(F)(F)F)c1)c1ccc(C(=O)O)cc1 CHEMBL3670685 IC50 4.5 nM
Cc1ccc(-c2nnn(Cc3ccc(C(F)(F)F)cc3)c2C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)s1 CHEMBL4548291 IC50 4.6 nM
C[C@H](NC(=O)c1cccc2c1N(Cc1ccc(C(F)(F)F)cc1Br)CC2)c1ccc(C(=O)O)cc1 CHEMBL1645149 IC50 4.7 nM
CCn1c2ccccc2c2cc(-c3nc4cc(C(=O)O)ccc4n3CCOC)ccc21 CHEMBL4483026 IC50 4.7 nM
CCc1nc2c(C)nc(C)cc2n1-c1ccc(CCNC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1 CHEMBL3039498 pA2 4.786 nM
C[C@H](NC(=O)c1cccc2ccn(Cc3cccc(C(F)(F)F)c3)c12)c1ccc(C(=O)O)cc1 CHEMBL1084551 Ki 4.8 nM
Cc1cc(O)ccc1-c1cccc(C(O)/C=C/[C@H]2CCC(=O)N2CCCCCCC(=O)O)c1 CHEMBL444574 Ki 4.9 nM
CCCCCC(O)CCc1c(Cl)cc(Cl)c(=O)n1CCc1ccc(C(=O)O)cc1 CHEMBL4640635 EC50 4.9 nM
CCCCCC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1 CHEMBL249136 EC50 5.0 nM
COc1ccc(-c2ccc(OCc3cc(C(=O)NS(=O)(=O)c4ccccc4)oc3C)cc2)cc1 CHEMBL3260456 Ki 5.0 nM
CCCS(=O)(=O)NC(=O)c1cc(COc2ccc(-c3ccc(OC)cc3)cc2)c(C)o1 CHEMBL3260461 Ki 5.0 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC(=O)O)cc1Cl)C2 CHEMBL4227555 pEC50 5.012 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC(=O)O)cc1Br)C2 CHEMBL4228070 pEC50 5.012 nM
COC(=O)c1ccc(CCCN2C(=O)C(F)(F)C[C@@H]2/C=C/[C@@H](O)[C@@H](C)Cc2ccccc2)s1 CHEMBL3911081 EC50 5.02 nM
C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(Cl)c1)c1ccc(C(=O)O)cc1 CHEMBL4062620 IC50 5.02 nM
C[C@H](NC(=O)c1c(Cc2cccc(F)c2)sc2c1CCOC2)c1ccc(C(=O)O)cc1 CHEMBL5202462 IC50 5.1 nM
Cc1ccc(C(=O)O)c(C)c1NC(=O)c1cc(-c2cccc(CO)c2)nc2ccccc12 CHEMBL3741902 IC50 5.2 nM
CC(NC(=O)c1sc(Cl)cc1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1 CHEMBL3695934 Ki 5.2 nM
CCn1c2ccc(-c3nc4c(C)c(C(=O)O)ccc4n3CCOC)cc2c2cccc(Cl)c21 CHEMBL4527180 IC50 5.2 nM
C[C@H](NC(=O)c1c2ccccc2nn1Cc1ccc(C(F)(F)F)cc1)c1ccc(C(=O)O)cc1 CHEMBL5394316 IC50 5.4 nM
O=C(O)c1ccc(C2(NC(=O)[C@H]3CCCCN3CCOc3ccccc3)CC2)cc1 CHEMBL3600788 IC50 5.42 nM
O=C(O)c1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 CHEMBL192613 Ki 5.5 nM
C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1 CHEMBL3115074 IC50 5.62 nM
Cc1ccc(N2CCC(O)CC2)nc1C(=O)Nc1c(C)cc(C(=O)O)cc1C CHEMBL3686863 IC50 5.62 nM
Cc1ccc(C(=O)O)c(C)c1NC(=O)c1cc(-c2ccccc2)cc2ccccc12 CHEMBL3739435 IC50 5.65 nM
O=C(O)c1ccc(CNC(=O)c2c3ccc(F)cc3nn2Cc2ccc(C(F)(F)F)cc2)cc1 CHEMBL5411028 IC50 5.7 nM
Cc1cc2ccccc2n1CCNC(=O)/C=C/c1ccc(OCCCO)cc1 CHEMBL3264229 Kb 5.96 nM
CCCCCC(O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O CHEMBL14334 Ki 6.0 nM
Cc1cc(Cl)ccc1-c1cccc([C@H](O)CC[C@H]2CCCC(=O)N2CCSCCCC(=O)O)c1 CHEMBL192743 EC50 6.1 nM
CCn1c2ccccc2c2cc(-c3nc4cc(-c5noc(=O)[nH]5)ccc4n3CCOC)ccc21 CHEMBL4581918 IC50 6.1 nM
O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccccc2Cl)c1 CHEMBL297578 Ki 6.2 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC(=O)O)c(F)c1)C2 CHEMBL4229058 pEC50 6.31 nM
C[C@H](NC(=O)c1cscc1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1 CHEMBL599051 Ki 6.4 nM
CC1(C)C(=O)[C@H](C/C=C\CCCC(=O)O)[C@@H](/C=C/C(O)CCc2ccccc2)[C@@H]1O CHEMBL3946494 EC50 6.4 nM
COc1ccc(Cn2nc3ccccc3c2C(=O)NCc2ccc(C(=O)O)cc2)cc1Cl CHEMBL5416297 IC50 6.5 nM
C[C@H](NC(=O)c1c(Cc2ccc(OC(F)(F)F)c(Cl)c2)sc2c1CCOC2)c1ccc(C(=O)O)cc1 CHEMBL5180884 IC50 6.6 nM
CCn1c2ccccc2c2cc(-c3nc4cc(-c5nnn[nH]5)ccc4n3CCOC)ccc21 CHEMBL4514122 IC50 6.8 nM
CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)s1 CHEMBL224970 Ki 6.9 nM
O=C(O)c1ccc(CNC(=O)c2c3ccccc3nn2Cc2cccc(Cl)c2)cc1 CHEMBL5395138 IC50 6.9 nM
O=C(O)c1ccc(C2(NC(=O)c3c4ccccc4nn3Cc3ccc(C(F)(F)F)cc3)CC2)cc1 CHEMBL5402258 IC50 6.9 nM
O=C(O)COCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(C(F)(F)F)c1 CHEMBL373558 Ki 7.0 nM
CC(C(=O)Nc1ccccc1Cc1ccccc1C(=O)O)c1cccc2ccccc12 CHEMBL3260772 Ki 7.0 nM
O=C(CCc1cc2c(cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC3CCCCC3)co1)OCO2)NS(=O)(=O)C(F)(F)F CHEMBL3967284 EC50 7.0 nM
CCn1c2ccccc2c2cc(-c3nc4cc(C(=O)O)ccc4n3CC3CCCO3)ccc21 CHEMBL4530347 IC50 7.0 nM
CCCCCC(O)/C=C/c1c(Cl)cc(Cl)c(=O)n1CCc1ccc(C(=O)O)cc1 CHEMBL4640391 EC50 7.0 nM
O=C(O)c1ccc(CNC(=O)c2c3ccccc3nn2Cc2ccc(F)cc2)cc1 CHEMBL5426943 IC50 7.1 nM
Cc1cc2ccccc2n1CCNC(=O)/C=C/c1ccc(OCCO)c(OCCO)c1 CHEMBL3264225 Kb 7.13 nM
COc1ccc(Cn2nc3ccccc3c2C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)cc1 CHEMBL5395204 IC50 7.2 nM
O=C(O)CCCCCCN1C(=O)CC[C@@H]1CC[C@@H](O)c1cccc(C(F)(F)F)c1 CHEMBL291182 Ki 7.4 nM
C[C@H](NC(=O)c1c(Cl)sc(Cl)c1C(=O)c1cccc(Cl)c1)c1ccc(C(=O)O)cc1 CHEMBL3695941 Ki 7.4 nM
COc1cc(/C=C/C(=O)NCCn2c(C)cc3ccccc32)cc(OC)c1OCCO CHEMBL3264230 Kb 7.49 nM
O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)CC1CCCCC1 CHEMBL42129 Ki 7.5 nM
C[C@H](NC(=O)c1cccc2c1N(Cc1cccc(C#N)c1)CC2)c1ccc(C(=O)O)cc1 CHEMBL1645151 Ki 7.5 nM
COc1c(F)cc(Cn2nc3ccccc3c2C(=O)NCc2ccc(C(=O)O)cc2)cc1F CHEMBL5429723 IC50 7.5 nM
Cc1cc2ccccc2n1CCNC(=O)/C=C/c1ccc(OCCO)cc1 CHEMBL3264228 Kb 7.58 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CS(=O)(=O)NC(=O)C(c3ccccc3)c3ccccc3)cc1)C2 CHEMBL404653 Ki 7.9 nM
COc1cc(/C=C/C(=O)NCCn2c(C(F)(F)F)cc3ccccc32)cc(OC)c1OCCO CHEMBL3264231 Kb 7.93 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC(=O)O)cc1C)C2 CHEMBL4225980 pEC50 7.943 nM
Cn1nc(C(F)F)c(C(=O)NC2(c3ccc(C(=O)O)cc3)CC2)c1Oc1cccc(C(F)(F)F)c1 CHEMBL3670687 Ki 8.0 nM
C[C@H](NC(=O)C1CC(C)(C)CCN1Cc1ccc(C(F)(F)F)cc1)c1ccc(C(=O)O)cc1 CHEMBL3930412 IC50 8.0 nM
O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc3c(c2)OCCO3)cc1 CHEMBL3974337 EC50 8.0 nM
COC(=O)c1ccc(CCCN2C(=O)C(F)(F)C[C@@H]2/C=C/[C@@H](O)[C@@H](C)CCc2ccccc2)s1 CHEMBL3973091 EC50 8.09 nM
Cc1cc(O)ccc1-c1cccc([C@H](O)CC[C@H]2CCC(=O)N2CCCCCCC(=O)O)c1 CHEMBL296715 Ki 8.2 nM
O=C(O)CCCCCNC(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)c1cc2ccccc2o1 CHEMBL190185 Ki 8.4 nM
C[C@H](NC(=O)c1c(-c2ccccc2)nnn1Cc1ccc(C(F)(F)F)cc1)c1ccc(C(=O)O)cc1 CHEMBL4463343 IC50 8.5 nM
C[C@H](NC(=O)[C@H]1CC(F)(F)CCN1Cc1ccc(C(F)(F)F)cc1)c1ccc(C(=O)O)cc1 CHEMBL3907863 IC50 9.0 nM
COc1ccc(Cn2nnc(-c3ccccc3)c2C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)cc1 CHEMBL4462095 IC50 9.3 nM
Cc1[nH]c2ccccc2c1CCNC(=O)/C=C/c1ccc(OCCO)c(OCCO)c1 CHEMBL3264227 Kb 9.5 nM
C[C@H](NC(=O)c1c(Cc2ccc(C(C)(C)C)cc2)sc2c1CCOC2)c1ccc(C(=O)O)cc1 CHEMBL5202597 IC50 9.5 nM
CCOc1c2c(c(OCC)c3ncccc13)CN(c1ccc(CS(=O)(=O)NC(=O)Cc3ccncc3)cc1C)C2=O CHEMBL272571 Ki 9.8 nM
O=C(O)c1ccc(CNC(=O)c2c3ccc(Cl)cc3nn2Cc2ccc(C(F)(F)F)cc2)cc1 CHEMBL5401228 IC50 9.9 nM
O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1ccc(C(F)(F)F)o1 CHEMBL45418 Ki 10.0 nM
Cc1cc(C)c2sc(C(=O)N(C)C)c(-c3ccc(CCC(=O)O)cc3)c2c1 CHEMBL1644001 Ki 10.0 nM
C[C@H](NC(=O)c1c(C(F)F)nn(C)c1Oc1cccc(OC(F)F)c1)c1ccc(C(=O)O)cc1 CHEMBL3670688 Ki 10.0 nM
O=C(CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F CHEMBL3942394 EC50 10.0 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC(=O)O)cc1OC)C2 CHEMBL4229001 pEC50 10.0 nM
C[C@H](NC(=O)c1c(CCc2ccc(F)cc2)sc2c1CCC2)c1ccc(C(=O)O)cc1 CHEMBL5181722 IC50 10.3 nM
C/C=C/c1nnn(Cc2ccc(C(F)(F)F)cc2)c1C(=O)NCc1ccc(C(=O)O)cc1 CHEMBL4455965 IC50 10.5 nM
COc1ccc(-c2ccc(OCc3cc(C(=O)NS(=O)(=O)c4ccc(O)cc4)oc3C)cc2)cc1 CHEMBL3260462 Ki 11.0 nM
O=C(O)c1ccc(C2(NC(=O)C3CC(F)(F)CCN3Cc3ccc(C(F)(F)F)cc3)CC2)cc1 CHEMBL3916857 IC50 11.0 nM
C[C@H](NC(=O)c1c2ccccc2nn1Cc1ccc(Cl)cc1)c1ccc(C(=O)O)cc1 CHEMBL5431483 IC50 11.0 nM
COc1cc(/C=C/C(=O)NCCn2c(C(F)(F)F)cc3ccccc32)cc(OC)c1OC CHEMBL3264204 Kb 11.2 nM
Cc1cc(C(=O)O)cc(C)c1NC(=O)c1cc(-c2ccccc2)nc2ccccc12 CHEMBL3741642 IC50 11.2 nM
COc1cc(/C=C/C(=O)NCCn2c(C)cc3ccccc32)cc(OC)c1OC CHEMBL1368005 Kb 11.4 nM
O=C(O)c1ccc(C2(NC(=O)C3CC4CC4CN3Cc3ccc(C(F)(F)F)cc3)CC2)cc1 CHEMBL3953493 IC50 11.5 nM
O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)C1(c2ccccc2)CC1 CHEMBL280223 Ki 12.0 nM
COc1cccc(Cn2nc3ccccc3c2C(=O)NCc2ccc(C(=O)O)cc2)c1 CHEMBL5430051 IC50 12.0 nM
COc1cccc(C#Cc2sc3c(c2C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)CCOC3)c1 CHEMBL5201557 IC50 12.4 nM
CCn1c2ccccc2c2cc(-c3nc4cc(C(=O)O)ccc4n3CC3CC3)ccc21 CHEMBL4584103 IC50 12.8 nM
C[C@H](NC(=O)c1c(-c2ccsc2)nnn1Cc1ccc(C(F)(F)F)cc1)c1ccc(C(=O)O)cc1 CHEMBL4564092 IC50 12.9 nM
O=C(O)CSCCCCN1C(=O)CC[C@@H]1/C=C/C(O)Cc1ccccc1 CHEMBL430124 Ki 13.0 nM
COc1ccc(-c2ccc(OCc3cc(C(=O)NS(=O)(=O)c4c(C)noc4C)oc3C)cc2)nc1 CHEMBL3260769 Ki 13.0 nM
C[C@H](NC(=O)c1c(C(F)(F)F)nn(C)c1Oc1ccc(Cl)c(Cl)c1)c1ccc(C(=O)O)cc1 CHEMBL3670686 Ki 13.0 nM
O=C(O)c1ccc(CNC(=O)c2c3ccccc3nn2Cc2cccc(C(F)(F)F)c2)cc1 CHEMBL5433721 IC50 13.0 nM
C[C@H](NC(=O)c1c2ccccc2nn1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1 CHEMBL5427264 IC50 13.0 nM
C[C@H](NC(=O)c1c(CCc2ccc(F)cc2)sc2c1COCC2)c1ccc(C(=O)O)cc1 CHEMBL5208903 IC50 13.1 nM
C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(C#N)c1)c1ccc(C(=O)O)cc1 CHEMBL4094572 IC50 13.4 nM
C/C=C/c1nnn(Cc2ccc(C(F)(F)F)cc2)c1C(=O)NC1(c2ccc(C(=O)O)cc2)CC1 CHEMBL4576681 IC50 13.9 nM
C/C=C/c1nnn(Cc2ccc(C(F)(F)F)cc2)c1C(=O)NCC1CCC(C(=O)O)CC1 CHEMBL4550862 IC50 13.9 nM
C[C@H](NC(=O)c1cccc2c1N(Cc1ccc(C(C)(C)C)cc1)CC2)c1ccc(C(=O)O)cc1 CHEMBL1645147 Ki 14.0 nM
Cc1cc(C)c2sc(C(=O)N(C)C)c(-c3ccc(-c4nn[nH]n4)cc3)c2c1 CHEMBL1643999 Ki 14.0 nM
Cc1oc(C(=O)NS(=O)(=O)c2ccccc2)cc1CNc1ccc(-c2ccccc2)cc1 CHEMBL3260765 Ki 14.0 nM
Cc1nn(C)c(Oc2cccc(C(F)(F)F)c2)c1C(=O)N[C@@H](C)c1ccc(C(=O)O)cc1 CHEMBL3670681 Ki 14.0 nM
Cc1ccc(N2CCCC(CO)C2)nc1C(=O)Nc1c(C)ccc(C(=O)O)c1C CHEMBL3793928 IC50 14.2 nM
CC[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1 CHEMBL3600787 IC50 14.4 nM
CCn1c2ccccc2c2cc(-c3nc4cc(C(=O)NS(=O)(=O)c5cccc(Cl)c5)ccc4n3CCOC)ccc21 CHEMBL4483339 IC50 14.7 nM
CCCC/C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1 CHEMBL251504 EC50 15.0 nM
COc1ccc(-c2ccc(OCc3cc(C(=O)NS(=O)(=O)c4ccc(C)cn4)oc3C)cc2)cc1 CHEMBL3260763 Ki 15.0 nM
O=C(O)c1ccc(C2(NC(=O)C3CC(F)(F)CCN3Cc3cccc(C(F)(F)F)c3)CC2)cc1 CHEMBL3944767 IC50 15.0 nM
O=C(NC1CC2(C1)CC(C(=O)O)C2)c1c2ccccc2nn1Cc1ccc(C(F)(F)F)cc1 CHEMBL5426152 IC50 15.0 nM
CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4c3c(cn4C)C[C@H]21 CHEMBL19215 Activity 15.2 nM
CCn1c2ccc(C)cc2c2cc(-c3nc4c(C)c(C(=O)O)ccc4n3CCOC)ccc21 CHEMBL4526403 IC50 15.3 nM
C[C@H](NC(=O)c1c(C#Cc2ccc(F)cc2)sc2c1CCOC2)c1ccc(C(=O)O)cc1 CHEMBL5175990 IC50 15.8 nM
CCn1c2ccccc2c2cc(-c3nc4c(Cl)c(C(=O)O)ccc4n3CCOC)ccc21 CHEMBL4563081 IC50 15.9 nM
O=C(O)CCCCCCN1C(=O)CC[C@@H]1CC[C@@H](O)Cc1cccc(C(F)(F)F)c1 CHEMBL46395 Ki 16.0 nM
Cn1nc(C(F)(F)F)c(C(=O)NC2(c3ccc(C(=O)O)cc3)CC2)c1Oc1cccc(C(F)(F)F)c1 CHEMBL3670683 Ki 16.0 nM
O=C(O)c1ccc(C2(NC(=O)[C@H]3C[C@H]4C[C@H]4N3Cc3cccc(C(F)(F)F)c3)CC2)cc1 CHEMBL4111368 IC50 16.0 nM
O=C(O)c1ccc(CNC(=O)c2c3ccccc3nn2Cc2ccc(F)c(F)c2)cc1 CHEMBL5393749 IC50 16.1 nM
Cc1ccc(N2CCCC(CO)C2)nc1C(=O)Nc1c(C)cc(C(=O)O)cc1C CHEMBL3793956 IC50 16.5 nM
O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)Cc1cccc(C(F)(F)F)c1 CHEMBL440474 EC50 17.0 nM
CCCCC[C@H](O)CC[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1 CHEMBL376347 Ki 17.0 nM
O=C(O)c1ccc(CNC(=O)c2c3ccccc3nn2Cc2cccc(F)c2)cc1 CHEMBL5435216 IC50 17.0 nM
CCn1c2ccc(-c3nc4c(C)c(C(=O)O)ccc4n3CCOC)cc2c2cc(C(F)(F)F)ccc21 CHEMBL4531968 IC50 17.4 nM
O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2CC[C@@H](O)CCC2CCC2)cc1 CHEMBL223744 Ki 18.0 nM
COCCn1c2ccccc2c2cc(-c3nc4cc(C(=O)O)ccc4n3CC3CC3)ccc21 CHEMBL4548032 IC50 18.0 nM
O=C(O)c1ccc(CNC(=O)[C@H]2CCCCN2CCOc2ccccc2)cc1 CHEMBL3600786 IC50 18.1 nM
CCCCCCCCNC(=O)c1coc([C@@H]2CCCN2Cc2cc(F)ccc2CCC(=O)NS(=O)(=O)C(F)(F)F)n1 CHEMBL3896035 EC50 19.0 nM
COc1cccc(Cn2nc3ccccc3c2C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1 CHEMBL5405516 IC50 19.0 nM
C[C@H](NC(=O)c1c(CCc2ccc(F)cc2)sc2c1CCOC2)c1ccc(C(=O)O)cc1 CHEMBL5195058 IC50 19.1 nM
Cc1ccc(N2CCC(O)CC2)nc1C(=O)Nc1c(C)ccc(C(=O)O)c1C CHEMBL3792709 IC50 19.5 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC(=O)O)cc1)C2 CHEMBL4225786 pEC50 19.95 nM
CCOc1c2c(c(OCC)c3cc(C)ccc13)C(=O)N(c1ccc(CC(=O)O)cc1)C2=O CHEMBL4225963 pEC50 19.95 nM
Cc1oc(C(=O)O)cc1COc1ccc(-c2ccc(OC(F)F)cc2)cc1 CHEMBL3260443 Ki 20.0 nM
CC(=O)c1ccc(-c2ccc(OCc3cc(C(=O)NS(=O)(=O)c4ccccc4)oc3C)cc2)cc1 CHEMBL3260459 Ki 20.0 nM
C[C@H](NC(=O)c1cccc2c(Cl)cn(Cc3cccc(Cl)c3)c12)c1ccc(C(=O)O)cc1 CHEMBL1083445 Ki 20.1 nM
CCCC/C=C(C)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1 CHEMBL398948 EC50 21.0 nM
COc1ccc(-c2ccc(OCc3cc(C(=O)NS(=O)(=O)c4ccccc4)oc3C)cc2)c(C)c1 CHEMBL3260759 Ki 21.0 nM
O=C(O)c1ccc(C2(NC(=O)[C@H]3C[C@H]4C[C@H]4N3Cc3ccc(C(F)(F)F)cc3)CC2)cc1 CHEMBL4109532 IC50 21.0 nM
O=C(O)c1ccc(CNC(=O)c2cc(Cl)ccc2Oc2ccc(F)cc2)cc1 CHEMBL4066230 IC50 21.6 nM
O=C(O)c1ccc(CNC(=O)c2c3ccccc3nn2CCOc2ccc(Cl)cc2)cc1 CHEMBL5401935 IC50 21.8 nM
Cc1cc(C)c2sc(C(=O)N(C)C)c(-c3ccc(CCc4nn[nH]n4)cc3)c2c1 CHEMBL1644000 Ki 22.0 nM
COc1ccc(-c2ccc(OCc3cc(C(=O)NS(=O)(=O)c4ccccc4)oc3C)cc2)nc1 CHEMBL3260458 Ki 22.0 nM
O=C(O)c1ccc(C2(NC(=O)C3CC4(CCN3Cc3ccc(C(F)(F)F)cc3)CC4)CC2)cc1 CHEMBL3920982 IC50 22.0 nM
CCn1c2ccccc2c2cc(-c3nc4cc(C(=O)O)ccc4n3CCC3CC3)ccc21 CHEMBL4551140 IC50 22.1 nM
C[C@H](NC(=O)c1c(-c2ccccc2)nnn1Cc1cccc(C(F)(F)F)c1)c1ccc(C(=O)O)cc1 CHEMBL4569593 IC50 23.0 nM
CCn1c2ccccc2c2cc(-c3nc4cc(C(=O)NS(C)(=O)=O)ccc4n3CCOC)ccc21 CHEMBL4587481 IC50 23.8 nM
COc1ccc(-c2ccc(OCc3cc(C(=O)NS(=O)(=O)c4c(C)noc4C)oc3C)cc2)c(C)c1 CHEMBL3260770 Ki 24.0 nM
CCn1c2ccccc2c2cc(-c3nc4c(C)c(C(=O)O)ccc4n3CCOC)ccc21 CHEMBL4541894 IC50 24.7 nM
Cc1oc(C(=O)NS(=O)(=O)c2ccccc2)cc1COc1ccc(-c2ccccc2)cc1 CHEMBL3260455 Ki 25.0 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC(=O)O)cc1)C2=O CHEMBL4224936 pEC50 25.12 nM
O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2cccc(I)c2)cc1 CHEMBL398827 Ki 26.0 nM
C[C@H](NC(=O)c1c(C(F)F)nn(C)c1Oc1cccc(C(F)F)c1)c1ccc(C(=O)O)cc1 CHEMBL3670689 Ki 26.0 nM
CCCC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1 CHEMBL4217198 EC50 26.0 nM
O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(I)c2)cc1 CHEMBL404414 Ki 27.0 nM
CCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1 CHEMBL271488 Ki 27.0 nM
O=C(O)c1ccc(C2(NC(=O)c3cccc4c3Oc3ccc(C(F)(F)F)cc3CC4)CC2)cc1 CHEMBL1910025 IC50 27.0 nM
COc1ccc2cc(C#Cc3sc4c(c3C(=O)N[C@@H](C)c3ccc(C(=O)O)cc3)CCOC4)ccc2c1 CHEMBL5191478 IC50 27.2 nM
C[C@H](NC(=O)c1c(CCc2ccc(F)cc2)sc2c1CCCC2)c1ccc(C(=O)O)cc1 CHEMBL5179032 IC50 27.8 nM
C[C@H](NC(=O)c1c(C2=CCCC2)nnn1Cc1ccc(C(F)(F)F)cc1)c1ccc(C(=O)O)cc1 CHEMBL4453648 IC50 27.9 nM
CCCCCC(O)CC[C@H]1CCC(=O)N1CCCCCCC(=O)O CHEMBL428524 Ki 28.0 nM
O=C(O)c1ccc(C2(NC(=O)[C@H]3CC(F)(F)CCN3Cc3ccc(C(F)(F)F)cc3)CC2)cc1 CHEMBL4109410 IC50 28.0 nM
C[C@H](NC(=O)c1cc(F)cnc1Oc1ccc(F)cc1)c1ccc(C(=O)O)cc1 CHEMBL4095293 IC50 28.7 nM
Cc1cc(C)c2sc(C(=O)N(C)C)c(-c3ccc(CCNC(=O)OC(C)(C)C)cc3)c2c1 CHEMBL1644015 Ki 29.0 nM
C[C@H](NC(=O)C1CC2(CCN1Cc1ccc(C(F)(F)F)cc1)CC2)c1ccc(C(=O)O)cc1 CHEMBL3963981 IC50 29.0 nM
CCCCCC(C)(O)/C=C/c1c(Cl)cc(Cl)c(=O)n1CCc1ccc(C(=O)O)cc1 CHEMBL4633041 EC50 29.0 nM
COc1ccc(Cn2nnc(-c3ccccc3)c2C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)cc1F CHEMBL4442135 IC50 29.8 nM
C[C@H](NC(=O)c1cccc2c1N(Cc1ccc(C(N)=O)cc1)CC2)c1ccc(C(=O)O)cc1 CHEMBL1645145 Ki 30.0 nM
C[C@H](NC(=O)c1cccc2c1N(Cc1cccc(C(N)=O)c1)CC2)c1ccc(C(=O)O)cc1 CHEMBL1645150 Ki 30.0 nM
Cc1sc(C)c(C(=O)NCc2ccc(C(=O)O)c(Cl)c2)c1Cc1cccc(Cl)c1 CHEMBL3695944 Ki 30.0 nM
O=C(NCC1CCC(C(=O)O)CC1)c1c(Cc2ccc(F)cc2)sc2c1CCOC2 CHEMBL5193793 IC50 30.3 nM
CCOc1c2c(c(OCC)c3ncccc13)C(=O)N(c1ccc(CC(=O)O)cc1)C2=O CHEMBL4229200 pKi 31.62 nM
O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(Oc2ccccc2)c1 CHEMBL288978 Ki 32.0 nM
CC1(C)C(=O)[C@H](CC#CCCCC(=O)O)[C@@H](/C=C\C(O)CCc2sc3ccccc3c2Cl)[C@@H]1O CHEMBL3950189 EC50 32.0 nM
O=C([O-])c1ccc(C2(NC(=O)[C@H]3CCCCN3Cc3ccc(C(F)(F)F)cc3)CC2)cc1 CHEMBL4111996 IC50 32.0 nM
CC#Cc1nnn(Cc2ccc(C(F)(F)F)cc2)c1C(=O)N[C@@H](C)c1ccc(C(=O)O)cc1 CHEMBL4591792 IC50 32.0 nM
C[C@H](NC(=O)c1c(NCc2ccc(C(F)(F)F)cc2)sc2c1CCOC2)c1ccc(C(=O)O)cc1 CHEMBL5188328 IC50 32.9 nM
O=C(O)c1csc([C@H]2CC[C@@H]3[C@@H](/C=C/[C@@H](O)COc4ccccc4)[C@H](O)C[C@@H]3O2)n1 CHEMBL3804978 EC50 33.0 nM
O=C(O)c1ccc2c(c1)nc(-c1ccc3c(c1)c1ccccc1n3CC1CC1)n2CC1CC1 CHEMBL4571025 IC50 33.8 nM
O=C(O)CCCSCCN1C(=O)CCC[C@@H]1/C=C/[C@@H](O)CCC1CCC1 CHEMBL372894 EC50 34.0 nM
Cn1c2ccccc2c2cc(-c3nc4cc(C(=O)O)ccc4n3CC3CC3)ccc21 CHEMBL4556932 IC50 34.2 nM
CCn1c2ccccc2c2cc(-c3nc4cc(C(=O)O)c(F)cc4n3CCOC)ccc21 CHEMBL4530975 IC50 34.6 nM
CCCCCC(O)CCC1CCC(=O)N1CCCCCCC(=O)O CHEMBL15096 Ki 35.0 nM
C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccc(C#N)cc1)c1ccc(C(=O)O)cc1 CHEMBL3600883 IC50 35.8 nM
O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(F)c2)cc1 CHEMBL400446 Ki 36.0 nM
C[C@H](NC(=O)c1c(CCc2ccc(F)cc2)sc2c1CC(C)(C)OC2)c1ccc(C(=O)O)cc1 CHEMBL5203156 IC50 36.2 nM
O=C(NCC1CCC(C(=O)O)CC1)c1c(Cc2cccc(C(F)(F)F)c2)sc2c1CCOC2 CHEMBL5196717 IC50 36.6 nM
COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(C(=O)NCCCCC3CCCCC3)co2)c1 CHEMBL3904989 EC50 37.0 nM
O=C(O)c1ccc(CNC(=O)c2cc(Cl)cnc2Oc2ccc(F)cc2)cc1 CHEMBL4065183 IC50 37.9 nM
O=C(CCc1ccc(F)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F CHEMBL3972583 EC50 38.0 nM
Cc1cn(Cc2cccc(Cl)c2)c2c(C(=O)N[C@@H](C)c3ccc(C(=O)O)cc3)cccc12 CHEMBL1083746 Ki 39.5 nM
Cc1ccc(N2CCC(C)(O)CC2)nc1C(=O)Nc1c(C)cc(C(=O)O)cc1C CHEMBL3793924 IC50 39.8 nM
CC(C)Oc1c2c(c(OC(C)C)c3ccccc13)C(=O)N(c1ccc(CC(=O)O)cc1)C2 CHEMBL4226523 pEC50 39.81 nM
Cc1cc(/C=C/C(=O)NCCn2c(C)cc3ccccc32)cc(C)c1F CHEMBL3264203 Kb 41.0 nM
C[C@H](NC(=O)c1cc(Cl)ccc1Oc1cccc(Cl)c1)c1ccc(C(=O)O)cc1 CHEMBL4095176 IC50 41.1 nM
C[C@H](NC(=O)c1cccc2c1Oc1ccc(C(F)(F)F)cc1CC2)c1ccc(C(=O)O)cc1 CHEMBL1910024 IC50 42.0 nM
C[C@H](NC(=O)[C@H]1CCC2CC2N1Cc1ccc(C(F)(F)F)cc1)c1ccc(C(=O)O)cc1 CHEMBL3967868 IC50 42.0 nM
O=C(NCCC[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)OCc1ccccc1 CHEMBL191898 Ki 43.0 nM
Cc1nn(C)c(Oc2cccc(C(F)(F)F)c2)c1C(=O)NC1(c2ccc(C(=O)O)cc2)CC1 CHEMBL3670682 Ki 43.0 nM
O=C(O)c1ccc(C2(NC(=O)[C@H]3CCC4CC4N3Cc3ccc(C(F)(F)F)cc3)CC2)cc1 CHEMBL4108479 IC50 43.0 nM
CCn1c2ccccc2c2cc(-c3nc4cc(-c5n[nH]c(=O)o5)ccc4n3CCOC)ccc21 CHEMBL4579666 IC50 43.7 nM
COCc1cccc(C[C@H](O)/C=C/[C@H]2CCCC(=O)N2CCSCCCC(=O)O)c1 CHEMBL372436 EC50 44.0 nM
COCc1cccc(C[C@H](O)/C=C/[C@H]2CCCC(=O)N2CCCCCCC(=O)O)c1 CHEMBL413563 EC50 44.0 nM
CC(CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1)Cc1cccc(CCc2ccccc2)c1 CHEMBL400447 Ki 44.0 nM
COC(=O)CCC/C=C\C[C@H]1C(=O)C(C)(C)[C@@H](O)[C@@H]1/C=C/C(O)Cc1ccccc1 CHEMBL3986534 IC50 45.0 nM
C[C@H](NC(=O)c1c(Nc2cccc(Cl)c2)c2ccccc2n1C)c1ccc(C(=O)O)cc1 CHEMBL5435929 IC50 45.5 nM
C[C@H](NC(=O)c1c(-c2ccoc2)nnn1Cc1ccc(C(F)(F)F)cc1)c1ccc(C(=O)O)cc1 CHEMBL4440382 IC50 45.6 nM
CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 CHEMBL314812 Ki 46.0 nM
Cn1c(C(=O)NC2(c3ccc(C(=O)O)cc3)CC2)c(Nc2cccc(C(F)(F)F)c2)c2ccccc21 CHEMBL5427309 IC50 47.1 nM
C[C@H](NC(=O)c1c(-c2ccccc2)nnn1CCOc1ccc(C(F)(F)F)cc1)c1ccc(C(=O)O)cc1 CHEMBL4574900 IC50 49.1 nM
C[C@H](NC(=O)c1c2ccccc2nn1Cc1ccc(F)cc1)c1ccc(C(=O)O)cc1 CHEMBL5419736 IC50 49.8 nM
O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccc(Cl)cc2)c1 CHEMBL46671 EC50 50.0 nM
O=C(O)Cc1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 CHEMBL189378 Ki 50.0 nM
C[C@H](NC(=O)c1c(C(F)F)nn(C)c1Oc1cccc(Cl)c1)c1ccc(C(=O)O)cc1 CHEMBL3670684 Ki 50.0 nM
C[C@H](NC(=O)[C@H]1CCCN1Cc1ccc(C(F)(F)F)cc1)c1ccc(C(=O)[O-])cc1 CHEMBL3894772 IC50 50.0 nM
CCOc1c2c(c(OCC)c3ccccc13)C(=O)N(c1ccc(CC(=O)O)cc1C(F)(F)F)C2 CHEMBL4224711 pEC50 50.12 nM
COC(=O)c1ccc(CCCN2C(=O)C(F)(F)C[C@@H]2/C=C/[C@H](O)[C@@H](C)CCCc2ccccc2)s1 CHEMBL3949313 EC50 50.8 nM
C[C@H](NC(=O)c1c(Cl)sc(Cl)c1C(OC1CCCCO1)c1cccc(Cl)c1)c1ccc(C(=O)O)cc1 CHEMBL3695939 Ki 51.0 nM
CCCCC[C@H](O)/C=C/[C@@H]1[C@@H](C/C=C\CCCC(=O)OC)C(=O)C(C)(C)[C@H]1O CHEMBL3978305 EC50 51.0 nM
CCn1c2ccccc2c2cc(-c3nc4cc(C(=O)O)ccc4n3CC3CCO3)ccc21 CHEMBL4585611 IC50 51.5 nM
C[C@H](NC(=O)c1c(C2CC2)nnn1Cc1ccc(C(F)(F)F)cc1)c1ccc(C(=O)O)cc1 CHEMBL4519666 IC50 52.1 nM
C[C@H](NC(=O)c1cccc2c1N(Cc1ccc(C(=O)O)cc1)CC2)c1ccc(C(=O)O)cc1 CHEMBL1645143 Ki 54.0 nM
C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1 CHEMBL3138992 Ki 54.0 nM
CCn1c2ccc(-c3nc4c(C)c(C(=O)O)ccc4n3CCOC)cc2c2c(C)cccc21 CHEMBL4554923 IC50 54.6 nM
Cc1cc2cccc(C(=O)N[C@@H](C)c3ccc(C(=O)O)cc3)c2n1Cc1cccc(Cl)c1 CHEMBL1084047 Ki 56.0 nM
O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(C(F)(F)F)c2)cc1 CHEMBL249540 Ki 57.0 nM
C[C@H](NC(=O)c1c(Nc2cccc([N+](=O)[O-])c2)c2ccccc2n1C)c1ccc(C(=O)O)cc1 CHEMBL5427471 IC50 57.3 nM
C[C@H](NC(=O)c1c(-c2ccc(F)cc2)nnn1Cc1ccc(C(F)(F)F)cc1)c1ccc(C(=O)O)cc1 CHEMBL4568156 IC50 57.9 nM
O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(OC(F)(F)F)c2)cc1 CHEMBL249539 Ki 59.0 nM
COc1ccc2c(C(=O)NCc3ccc(C(=O)O)cc3)n(Cc3ccc(C(F)(F)F)cc3)nc2c1 CHEMBL5421486 IC50 59.4 nM
Cc1cccc(Nc2c(C(=O)N[C@@H](C)c3ccc(C(=O)O)cc3)n(C)c3ccccc23)c1 CHEMBL5430749 IC50 60.2 nM
C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(C(F)(F)F)c1)c1ccc(C(=O)O)cc1 CHEMBL4074035 IC50 60.4 nM
C[C@H](NC(=O)c1cc(Cl)cnc1Oc1ccccc1F)c1ccc(C(=O)O)cc1 CHEMBL4064393 IC50 61.4 nM
CC(C)(c1ccccc1)C(O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O CHEMBL278451 Ki 62.0 nM
C[C@@H](c1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1 CHEMBL3986266 EC50 62.0 nM
CCCCC[C@H](O)/C=C/[C@@H]1[C@@H](CC#CCCCC(=O)O)C(=O)C(C)(C)[C@H]1O CHEMBL3966610 EC50 63.0 nM
CCCn1c2ccccc2c2cc(-c3nc4cc(C(=O)O)ccc4n3CC3CC3)ccc21 CHEMBL4529022 IC50 63.0 nM
C[C@H](NC(=O)c1c(C2CCCC2)nnn1Cc1ccc(C(F)(F)F)cc1)c1ccc(C(=O)O)cc1 CHEMBL4466382 IC50 65.1 nM
CCn1c2ccc(-c3nc4c(C)c(C(=O)O)ccc4n3CCOC)cc2c2c(Cl)cccc21 CHEMBL4536877 IC50 65.5 nM
O=C1CC[C@H](/C=C/C(O)Cc2ccccc2)N1CCCCSCc1nn[nH]n1 CHEMBL430121 Ki 66.0 nM
O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2ccccc2)cc1 CHEMBL249342 Ki 68.0 nM
O=C(O)c1ccc(CNC(=O)c2c3ccccc3nn2Cc2ccccc2)cc1 CHEMBL5417603 IC50 68.0 nM
CCCc1nnn(Cc2ccc(C(F)(F)F)cc2)c1C(=O)N[C@@H](C)c1ccc(C(=O)O)cc1 CHEMBL4562090 IC50 68.8 nM
O=C(O)c1ccc(CNC(=O)c2c3ccccc3nn2CCOc2cccc(C(F)(F)F)c2)cc1 CHEMBL5414398 IC50 69.1 nM
CCCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1 CHEMBL3753221 EC50 73.0 nM
O=C(O)c1ccc(CNC(=O)c2cc(F)cnc2Oc2ccc(F)cc2)cc1 CHEMBL4103046 Ki 73.0 nM
C[C@H](NC(=O)c1c(Cc2ccc(F)cc2)sc2c1CCOC2)c1ccc(C(=O)NN)cc1 CHEMBL5190720 IC50 74.9 nM
C[C@H](NC(=O)c1c(C2CCC2)nnn1Cc1ccc(C(F)(F)F)cc1)c1ccc(C(=O)O)cc1 CHEMBL4589657 IC50 75.3 nM
C[C@H](NC(=O)c1cccc2c1N(Cc1cccnc1)CC2)c1ccc(C(=O)O)cc1 CHEMBL1645146 Ki 76.0 nM
CCOc1c2c(c(OCC)c3cc(F)ccc13)C(=O)N(c1ccc(CC(=O)O)cc1)C2=O CHEMBL4227838 pEC50 79.43 nM
O=C(O)c1ccc(CNC(=O)c2c3ccccc3nn2CCOc2ccc(F)cc2)cc1 CHEMBL5408723 IC50 79.6 nM
CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=O)OCc1ccccc1)NC(=O)c1cc2ccccc2[nH]1 CHEMBL192303 Ki 80.0 nM
Cc1oc(CC(=O)O)cc1COc1ccc(-c2ccccc2)cc1 CHEMBL3260430 Ki 80.0 nM
Cc1oc(CCC(=O)O)cc1COc1ccc(-c2ccccc2)cc1 CHEMBL3260431 Ki 80.0 nM
C[C@H](NC(=O)c1c(Nc2cccc(F)c2)c2ccccc2n1C)c1ccc(C(=O)O)cc1 CHEMBL5426990 IC50 80.7 nM
CCn1c2ccccc2c2cc(-c3nc4cc(C(=O)O)ccc4n3CCN(C)C)ccc21 CHEMBL4559616 IC50 82.5 nM
Cc1ccc(N2CCC(CO)C2)nc1C(=O)Nc1c(C)cc(C(=O)O)cc1C CHEMBL3793994 IC50 84.0 nM
COc1ccccc1-c1ccc(OCc2cc(C(=O)NS(=O)(=O)c3ccccc3)oc2C)cc1 CHEMBL3260760 Ki 85.0 nM
Cc1ccc(N2CCC(C)(O)CC2)nc1C(=O)Nc1c(C)ccc(C(=O)O)c1C CHEMBL3792999 IC50 87.9 nM
COc1ccc(-c2ccc(OCc3cc(C(=O)O)oc3C)cc2)cc1 CHEMBL3260437 Ki 90.0 nM
CCCCCC(C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1 CHEMBL4206444 EC50 91.0 nM
C[C@H](NC(=O)c1cc(Cl)cnc1Oc1ccccc1Cl)c1ccc(C(=O)O)cc1 CHEMBL4102314 IC50 93.5 nM
C[C@H](NC(=O)c1cc(Cl)cnc1Oc1ccc(Cl)cc1)c1ccc(C(=O)O)cc1 CHEMBL4084355 IC50 94.3 nM
COC1CCN(c2ccc(C)c(C(=O)Nc3c(C)cc(C(=O)O)cc3C)n2)CC1 CHEMBL3793912 IC50 96.7 nM
COc1cccc(Cn2nnc(-c3ccccc3)c2C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1 CHEMBL4455816 IC50 96.8 nM
COC(=O)CSCCCS[C@H]1C(=O)C(C)(C)[C@@H](O)[C@@H]1/C=C/C(O)CCc1sc2ccccc2c1Cl CHEMBL3954286 IC50 98.0 nM