COCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3c(Cl)cccc3C(F)(F)F)cc2[nH]1 CHEMBL3342696 IC50 0.1 nM
COCC(C)(C)CNc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3cc(Cl)ccc3Cl)cc2[nH]1 CHEMBL3896436 IC50 0.1 nM
COCc1nc2c(C(=O)Nc3cccs3)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3971013 IC50 0.1 nM
Cn1c(Nc2cc(CNC(=O)C3(C(F)(F)F)CC3)ccc2Cl)nc2cc(C(=O)NCC3CC3)c(OCC(F)F)cc21 CHEMBL4444875 IC50 0.1 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(C(C)(C)C)nc12 CHEMBL3956115 IC50 0.2 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(NCC(C)(C)C)nc12 CHEMBL3981545 IC50 0.2 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(N3CCCC3)nc12 CHEMBL3930662 IC50 0.3 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(NCCOC(C)(C)C)nc12 CHEMBL3899486 IC50 0.3 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(Cl)nc12 CHEMBL3962760 IC50 0.3 nM
CC(C)CCOc1ccc2c(c1)c1cc(CC(C)(C)O)ccc1c1[nH]c(-c3c(C#N)cccc3C#N)nc21 CHEMBL567696 IC50 0.4 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(CC(C)(C)C)nc12 CHEMBL3979324 IC50 0.4 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(NC3CCCC3)nc12 CHEMBL3952794 IC50 0.4 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(N3CCCCC3)nc12 CHEMBL3892483 IC50 0.4 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2cc(Cl)ccc2Cl)cc2[nH]c(NCCOC(C)C)nc12 CHEMBL3926077 IC50 0.4 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2c(F)cccc2Cl)cc2[nH]c(NCCOC(C)C)nc12 CHEMBL3897304 IC50 0.4 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(C(C)(C)CCl)nc12 CHEMBL3920661 IC50 0.5 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(C3(C)CC3)nc12 CHEMBL3970074 IC50 0.5 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2c(F)cccc2Cl)cc2[nH]c(NC(CO)C(C)C)nc12 CHEMBL3960895 IC50 0.5 nM
CC(C)(O)CCc1ccc2c(c1)c1cc(Cl)ccc1c1nc(-c3c(C#N)cccc3C#N)[nH]c21 CHEMBL482674 IC50 0.7 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2cc(Cl)ccc2Cl)cc2[nH]c(C3CC3)nc12 CHEMBL3962924 IC50 0.7 nM
Fc1cccc(Cl)c1-c1nc(-c2ccc(C#Cc3ccc(C(F)(F)F)cc3)nc2)c(Br)[nH]1 CHEMBL483894 IC50 0.8 nM
CCCC(C)(C)c1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3984205 IC50 0.8 nM
CC(C)(O)Cc1ccc2c(c1)c1cc(OCCC3CC3)ccc1c1nc(-c3c(C#N)cccc3C#N)[nH]c21 CHEMBL521285 IC50 0.9 nM
Cc1nc(NC(=O)c2cc(CNC(=O)C(C)C)cnc2C(F)F)[nH]c1-c1ccc(C(F)(F)F)cc1 CHEMBL3342693 IC50 0.9 nM
COCCc1nc2c(C(=O)Nc3ccc(C)c(Cl)c3)cc(NC(=O)c3cc(Cl)ccc3Cl)cc2[nH]1 CHEMBL3902537 IC50 0.9 nM
OC(c1ccc2c(c1)c1cc(Br)ccc1c1nc(-c3c(F)cccc3Cl)[nH]c21)(C(F)(F)F)C(F)(F)F CHEMBL585763 IC50 1.0 nM
N#Cc1cccc(C#N)c1-c1nc2c3ccc(Cl)cc3c3ccccc3c2[nH]1 CHEMBL412099 IC50 1.0 nM
N#CCCCOc1ccc2c(c1)c1cc(Cl)ccc1c1nc(-c3c(C#N)cccc3C#N)[nH]c21 CHEMBL585116 IC50 1.0 nM
N#Cc1cccc(C#N)c1-c1nc2c3ccc(Cl)cc3c3cc(OCCn4cccc4)ccc3c2[nH]1 CHEMBL585690 IC50 1.0 nM
N#Cc1cccc(C#N)c1-c1nc2c3ccc(Cl)cc3c3cc(C#Cc4cccnc4)ccc3c2[nH]1 CHEMBL568565 IC50 1.0 nM
N#Cc1cccc(C#N)c1-c1nc2c3ccc(Cl)cc3c3cc(C#Cc4ccncc4)ccc3c2[nH]1 CHEMBL567714 IC50 1.0 nM
CC(C)(O)C#Cc1ccc2c(c1)c1cc(Cl)ccc1c1nc(-c3c(C#N)cccc3C#N)[nH]c21 CHEMBL483900 IC50 1.0 nM
N#Cc1cccc(C#N)c1-c1nc2c3ccc(Cl)cc3c3cc(C#CC4(O)CCCC4)ccc3c2[nH]1 CHEMBL585134 IC50 1.0 nM
CCc1ccc2c(c1)c1cc(C#CC(C)(C)O)ccc1c1[nH]c(-c3c(C#N)cccc3C#N)nc21 CHEMBL585104 IC50 1.0 nM
CC(C)(O)C#Cc1ccc2c(c1)c1cc(C#CC3CC3)ccc1c1nc(-c3c(C#N)cccc3C#N)[nH]c21 CHEMBL566668 IC50 1.0 nM
CC(C)(O)Cc1ccc2c(c1)c1cc(OCCCC(F)(F)F)ccc1c1nc(-c3c(C#N)cccc3C#N)[nH]c21 CHEMBL567493 IC50 1.0 nM
CC(C)(O)Cc1ccc2c(c1)c1cc(OCCC3CC3)ccc1c1nc(-c3c(C#N)cc(F)cc3C#N)[nH]c21 CHEMBL565406 IC50 1.0 nM
CC(C)NC(=O)N(Cc1cccc(C#Cc2ccccc2)c1)Cc1cccc(C#CC2CC2)c1 CHEMBL1683210 IC50 1.0 nM
CC(C)NC(=O)N(Cc1cccc(C#Cc2ccc(Cl)cc2)c1)Cc1cccc(C#Cc2ccccn2)c1 CHEMBL1683214 IC50 1.0 nM
CC(C)NC(=O)N(Cc1cccc(C#Cc2ccc(Cl)cc2)c1)Cc1cccc(C#Cc2cccnc2)c1 CHEMBL1683215 IC50 1.0 nM
CC(C)NC(=O)N(Cc1cccc(C#Cc2ccccc2)c1)Cc1cccc(C#Cc2cccnc2)c1 CHEMBL3604189 IC50 1.0 nM
Fc1cccc(Cl)c1-c1nc(-c2ccc(C#Cc3ccccc3)nc2)c(Br)[nH]1 CHEMBL1289402 IC50 1.0 nM
Cc1cccc2ccc(N3CC[C@H](C(=O)N[C@H]4CC[C@@H](CO)CC4)C(C)(C)C3)nc12 CHEMBL3938686 IC50 1.0 nM
Cc1cccc2ccc(N3CC[C@H](C(=O)N[C@H]4CCC[C@H](CO)C4)C(C)(C)C3)nc12 CHEMBL3956184 IC50 1.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NC3CC(F)(F)C3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3660813 IC50 1.0 nM
CC(NC(=O)c1cc2nc(Nc3c(Cl)ccc(CNC(=O)C(C)(C)C)c3Cl)n(C)c2cc1N1CCC(F)(F)C1)C(F)(F)F CHEMBL3660837 IC50 1.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(Cl)c(F)c3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3660854 IC50 1.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3660855 IC50 1.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NC3CCC(F)(F)CC3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3660858 IC50 1.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(N3CC4CC4C3)cc21 CHEMBL3660862 IC50 1.0 nM
CC(C)(C)C(=O)NCc1ccc(Cl)c(Nc2nc3cc(C(=O)N[C@H]4CC[C@H](C(F)(F)F)CC4)c(N4CCOCC4)cc3n2CC(F)F)c1Cl CHEMBL3660868 IC50 1.0 nM
CC(C)(C)C(=O)NCc1ccc(Cl)c(Nc2nc3cc(C(=O)N[C@H]4CC[C@H](C(F)(F)F)CC4)c(N4CCC(C(F)(F)F)CC4)cc3n2CC(F)F)c1Cl CHEMBL3660871 IC50 1.0 nM
CC(C)(C)C(=O)NCc1ccc(Cl)c(Nc2nc3cc(C(=O)NCC(F)(F)C(F)(F)F)c(N4CCC(C(F)(F)F)CC4)cc3n2CC(F)F)c1Cl CHEMBL3660872 IC50 1.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CC(OC(F)F)C3)cc21 CHEMBL3665451 IC50 1.0 nM
C#CCN(C)c1cc2c(cc1C(=O)N[C@H]1CC[C@H](C(F)(F)F)CC1)nc(Nc1c(Cl)ccc(CNC(=O)C(C)(C)C)c1Cl)n2C CHEMBL3665455 IC50 1.0 nM
CN(CC1(C)CC1)c1cc2c(cc1C(=O)N[C@H]1CC[C@H](C(F)(F)F)CC1)nc(Nc1c(Cl)ccc(CNC(=O)C(C)(C)C)c1Cl)n2C CHEMBL3665459 IC50 1.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CCN(C4CC4)CC3)cc21 CHEMBL3665460 IC50 1.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(F)cc21 CHEMBL3694508 IC50 1.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3cccc(Cl)c3)c(F)cc21 CHEMBL3694509 IC50 1.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(Cl)c(F)c3)c(F)cc21 CHEMBL3694510 IC50 1.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3cc(F)cc(Cl)c3)c(F)cc21 CHEMBL3694514 IC50 1.0 nM
Cn1c(Nc2c(F)ccc(CNC(=O)C(C)(C)C)c2F)nc2cc(C(=O)Nc3cccc(F)c3)c(OCC(F)F)cc21 CHEMBL3694561 IC50 1.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)N3CC(F)(F)C3)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(OCC(F)F)cc21 CHEMBL3694569 IC50 1.0 nM
CC1CCCN1C(=O)NCc1ccc(Cl)c(Nc2nc3cc(C(=O)N[C@H]4CC[C@H](C(F)(F)F)CC4)c(OCC(F)F)cc3n2C)c1Cl CHEMBL3694571 IC50 1.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3c(F)ccc(F)c3F)c(OCC(F)F)cc21 CHEMBL3694572 IC50 1.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(OCCF)cc21 CHEMBL3694573 IC50 1.0 nM
COCCOc1cc2c(cc1C(=O)Nc1ccc(F)c(Cl)c1)nc(Nc1c(Cl)ccc(CNC(=O)C(C)(C)C)c1Cl)n2C CHEMBL3694574 IC50 1.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(OC3CCOC3)cc21 CHEMBL3694575 IC50 1.0 nM
Cc1ccc(NC(=O)c2cc(NC(=O)c3ccccc3C(F)(F)F)cc3[nH]c(C(C)(C)C)nc23)cc1Cl CHEMBL3895415 IC50 1.0 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(NCC(C)(C)O)nc12 CHEMBL3914711 IC50 1.0 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccc(Cl)cc2Cl)cc2[nH]c(N(C)C)nc12 CHEMBL3916792 IC50 1.0 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2c(Cl)cccc2Cl)cc2[nH]c([C@H]3CCCO3)nc12 CHEMBL4110463 IC50 1.0 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(N3CC[C@H](N(C)C)C3)nc12 CHEMBL3986801 IC50 1.0 nM
CN(C)c1nc2c(C(=O)Nc3ccc4c(c3)CCC4)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3964040 IC50 1.0 nM
Cc1ccc(NC(=O)c2cc(NC(=O)c3cc(Cl)ccc3Cl)cc3[nH]c(C4CC4)nc23)cc1Cl CHEMBL3897430 IC50 1.0 nM
O=C(O)c1ccc(Cl)cc1CC[C@@H]1CCC[C@@H]1NC(=O)C1CCN(c2ccc(C(F)(F)F)cc2)CC1 CHEMBL4102262 IC50 1.0 nM
Cc1ccc(C(=O)O)c(CC[C@@H]2CCC[C@@H]2NC(=O)C2CCN(c3ccc(C(F)(F)F)cc3)CC2)c1 CHEMBL4085873 IC50 1.0 nM
O=C(O)c1ccc(F)cc1CC[C@@H]1CCC[C@@H]1NC(=O)C1CCN(c2ccc(C(F)(F)F)cc2)CC1 CHEMBL4064335 IC50 1.0 nM
O=C(O)c1ccccc1CC[C@@H]1CCC[C@@H]1NC(=O)C1CCN(c2ccc(OC(F)(F)F)cc2)CC1 CHEMBL4084995 IC50 1.0 nM
Cc1cccc2ccc(N3CCC(C(=O)N[C@H]4CCC[C@H]4CCc4ccccc4C(=O)O)CC3)nc12 CHEMBL4101413 IC50 1.0 nM
COc1cc(-c2cc(C(=O)O)c3c(ccc4ccccc43)n2)ccc1OCCCC#N CHEMBL2336518 IC50 1.1 nM
COCC(C)(C)CN(C)c1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3933466 IC50 1.1 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(S(C)(=O)=O)nc12 CHEMBL3963963 IC50 1.1 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c([S+](C)[O-])nc12 CHEMBL3973372 IC50 1.1 nM
O=C(Oc1ccc(OCc2ccccc2)cc1)N(Nc1cccc(Cl)c1)S(=O)(=O)c1ccc(Cl)cc1 CHEMBL4851179 IC50 1.16 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(C3(C(F)(F)F)CC3)nc12 CHEMBL3964736 IC50 1.2 nM
CSCCNc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3916391 IC50 1.2 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(N3CCC3)nc12 CHEMBL3947321 IC50 1.3 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2cc(Cl)ccc2Cl)cc2[nH]c(NCC(C)(C)CO)nc12 CHEMBL3965972 IC50 1.4 nM
CN(C)c1nc2c(C(=O)Nc3ccc(C(C)(C)C)cc3)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3924377 IC50 1.4 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]cnc12 CHEMBL3925281 IC50 1.5 nM
COCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3cc(Cl)ccc3Br)cc2[nH]1 CHEMBL3969140 IC50 1.5 nM
COCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3c(Cl)cccc3Br)cc2[nH]1 CHEMBL3909185 IC50 1.6 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(N3CCOCC3)nc12 CHEMBL3925464 IC50 1.6 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2c(F)cccc2Cl)cc2[nH]c(N(C)C)nc12 CHEMBL3911363 IC50 1.6 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(N(C)C)nc12 CHEMBL3910571 IC50 1.6 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C(F)(F)F)c2Cl)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665512 IC50 1.7 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)F)c2Cl)nc2cc(C(=O)Nc3cccc(C(F)(F)F)n3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665521 IC50 1.7 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C(F)(F)F)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665528 IC50 1.7 nM
CC(C)(C)c1nc2c(C(=O)NCc3ncccc3C(F)(F)F)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3893624 IC50 1.7 nM
COCc1nc2c(C(=O)Nc3nc4cc(Cl)ccc4o3)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3980968 IC50 1.7 nM
O=C(O)CN1C(=O)/C(=C2/C(=O)N(CC(=O)O)c3ccccc32)SC1=S CHEMBL517107 IC50 1.8 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)F)c2Cl)nc2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665516 IC50 1.8 nM
COCc1nc2c(C(=O)Nc3ccc(C)cc3Cl)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3942114 IC50 1.8 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C(F)(F)F)c2Cl)nc2cc(C(=O)NC3CC(F)(F)C3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665532 IC50 1.9 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2c(Cl)cccc2Cl)cc2[nH]c(N(C)C)nc12 CHEMBL3978309 IC50 1.9 nM
CCNc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3944163 IC50 1.9 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(N3CC(O)C3)nc12 CHEMBL3917059 IC50 1.9 nM
COCc1nc2c(C(=O)Nc3cccc4cccnc34)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3951987 IC50 1.9 nM
COCc1nc2c(C(=O)NCC3CCCCCC3)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3920783 IC50 1.9 nM
Fc1cccc(Cl)c1-c1nc2c3ccc(Br)cc3c3ccccc3c2[nH]1 CHEMBL584932 IC50 2.0 nM
CS(=O)(=O)c1ccc(-c2ccc3c(c2)c2cc(Cl)ccc2c2nc(-c4c(C#N)cccc4C#N)[nH]c32)cc1 CHEMBL585295 IC50 2.0 nM
COCC#Cc1ccc2c(c1)c1cc(Cl)ccc1c1nc(-c3c(C#N)cccc3C#N)[nH]c21 CHEMBL585857 IC50 2.0 nM
CC(C)(O)Cc1ccc2c(c1)c1cc(Cl)ccc1c1nc(-c3c(C#N)cccc3C#N)[nH]c21 CHEMBL584927 IC50 2.0 nM
CC(C)NC(=O)N(Cc1cccc(C#Cc2ccccc2)c1)Cc1cncc(C#Cc2ccccc2)c1 CHEMBL1683213 IC50 2.0 nM
CC(C)NC(=O)N(Cc1cccc(C#Cc2ccncc2)c1)Cc1cccc(C#Cc2ccc(Cl)cc2)c1 CHEMBL1683217 IC50 2.0 nM
CCOC(=O)C1=C(C)N=c2s/c(=C\c3ccc(-c4ccc(Cl)c(C(=O)O)c4)o3)c(=O)n2C1c1ccccc1Cl CHEMBL2336520 IC50 2.0 nM
CC(c1ccccc1)N1C(=O)c2ccc(C(=O)Nc3cc(Cl)ccc3C(=O)O)cc2C1=O CHEMBL2336517 IC50 2.0 nM
O=C(N[C@H]1CCC[C@H](CO)C1)C1CCN(c2nc3cc(Cl)c(-c4ccc(OC(F)(F)F)cc4)cc3o2)CC1 CHEMBL2391142 IC50 2.0 nM
CC(C)(C)C(=O)NCc1ccc(Cl)c(C(=O)Nc2ccc(OCC(F)F)c(C(=O)Nc3ccc(Br)cc3)c2)c1 CHEMBL3342695 IC50 2.0 nM
Cc1cccc2ccc(N3CC[C@H](C(=O)N[C@H]4CCO[C@H](CO)C4)C(C)(C)C3)nc12 CHEMBL3928608 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(N3CCC(F)CC3)cc21 CHEMBL3660805 IC50 2.0 nM
CN(CC(F)F)c1cc2c(cc1C(=O)Nc1ccc(F)c(Cl)c1)nc(Nc1c(Cl)ccc(CNC(=O)C(C)(C)C)c1Cl)n2C CHEMBL3660806 IC50 2.0 nM
CC(C)(C)C(=O)NCc1ccc(F)c(Nc2nc3cc(C(=O)N[C@H]4CC[C@H](C(F)(F)F)CC4)c(N4CCC(F)CC4)cc3[nH]2)c1F CHEMBL3660808 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCC(F)(F)F)c(N3CCC(F)CC3)cc21 CHEMBL3660810 IC50 2.0 nM
CN(c1cc2c(cc1C(=O)NCC(F)(F)F)nc(Nc1c(Cl)ccc(CNC(=O)C(C)(C)C)c1Cl)n2C)C1CCCC1 CHEMBL3660825 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCC(F)(F)F)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3660826 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCC(F)(F)F)c(N3CCC(C(C)(C)O)CC3)cc21 CHEMBL3660827 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCC(F)(F)F)c(C3CCc4ccc(Cl)cc4C3)cc21 CHEMBL3660830 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)c(N3CCC(F)(F)C3)cc21 CHEMBL3660833 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3cccc(OC(F)(F)F)c3)c(N3CCC(F)(F)C3)cc21 CHEMBL3660838 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H](c3ccccc3)C(F)(F)F)c(N3CCC(F)(F)C3)cc21 CHEMBL3660839 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(N3CCC(F)(F)C3)cc21 CHEMBL3660840 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3cccc(C(F)(F)F)n3)c(N3CCC(F)(F)C3)cc21 CHEMBL3660845 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NC(Cc3ccccc3)C(F)(F)F)c(N3CCC(F)(F)C3)cc21 CHEMBL3660846 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCC(F)(F)C(F)(F)F)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3660851 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3660852 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3cccc(C(F)(F)F)n3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3660853 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCCC(F)(F)F)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3660859 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CCC(F)(F)CC3)cc21 CHEMBL3660866 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCC(F)(F)C(F)(F)F)c(N3CCC(F)(F)CC3)cc21 CHEMBL3660867 IC50 2.0 nM
CC1(O)CCN(c2cc3c(cc2C(=O)N[C@H]2CC[C@H](C(F)(F)F)CC2)nc(Nc2c(Cl)ccc(CNC(=O)C(C)(C)F)c2Cl)n3CC(F)F)CC1 CHEMBL3942194 IC50 2.0 nM
CC(C)(F)C(=O)NCc1ccc(Cl)c(Nc2nc3cc(C(=O)NC4CCC(C(F)(F)F)CC4)c(N4CCC(O)(C(F)(F)F)CC4)cc3n2CC(F)F)c1Cl CHEMBL3929686 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CCC(C)(O)C3)cc21 CHEMBL3660878 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CC(O)C3)cc21 CHEMBL3660882 IC50 2.0 nM
CN(Cc1nccn1C)c1cc2c(cc1C(=O)N[C@H]1CC[C@H](C(F)(F)F)CC1)nc(Nc1c(Cl)ccc(CNC(=O)C(C)(C)C)c1Cl)n2C CHEMBL3660883 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CCCC(C(F)(F)F)C3)cc21 CHEMBL3660884 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CC4CCC3CC4)cc21 CHEMBL3665445 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CC4CCCC43)cc21 CHEMBL3665448 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CC4CCCC4C3)cc21 CHEMBL3665453 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CC4COCC4C3)cc21 CHEMBL3665454 IC50 2.0 nM
COC(C)CN(C)c1cc2c(cc1C(=O)N[C@H]1CC[C@H](C(F)(F)F)CC1)nc(Nc1c(Cl)ccc(CNC(=O)C(C)(C)C)c1Cl)n2C CHEMBL3665456 IC50 2.0 nM
CN(CCS(C)(=O)=O)c1cc2c(cc1C(=O)N[C@H]1CC[C@H](C(F)(F)F)CC1)nc(Nc1c(Cl)ccc(CNC(=O)C(C)(C)C)c1Cl)n2C CHEMBL3665457 IC50 2.0 nM
CC(O)CN(C)c1cc2c(cc1C(=O)N[C@H]1CC[C@H](C(F)(F)F)CC1)nc(Nc1c(Cl)ccc(CNC(=O)C(C)(C)C)c1Cl)n2C CHEMBL3665458 IC50 2.0 nM
CN(CC(C)(C)O)c1cc2c(cc1C(=O)N[C@H]1CC[C@H](C(F)(F)F)CC1)nc(Nc1c(Cl)ccc(CNC(=O)C(C)(C)C)c1Cl)n2C CHEMBL3665461 IC50 2.0 nM
CN(Cc1ccc(F)cc1)c1cc2c(cc1C(=O)N[C@H]1CC[C@H](C(F)(F)F)CC1)nc(Nc1c(Cl)ccc(CNC(=O)C(C)(C)C)c1Cl)n2C CHEMBL3665462 IC50 2.0 nM
CN(CC(N)=O)c1cc2c(cc1C(=O)N[C@H]1CC[C@H](C(F)(F)F)CC1)nc(Nc1c(Cl)ccc(CNC(=O)C(C)(C)F)c1Cl)n2C CHEMBL3665463 IC50 2.0 nM
CN(Cc1nnc[nH]1)c1cc2c(cc1C(=O)N[C@H]1CC[C@H](C(F)(F)F)CC1)nc(Nc1c(Cl)ccc(CNC(=O)C(C)(C)C)c1Cl)n2C CHEMBL3665466 IC50 2.0 nM
CN(c1cc2c(cc1C(=O)N[C@H]1CC[C@H](C(F)(F)F)CC1)nc(Nc1c(Cl)ccc(CNC(=O)C(C)(C)C)c1Cl)n2C)C1CCS(=O)(=O)C1 CHEMBL3665468 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3C[C@H]4C[C@@H](C3)[C@H]4O)cc21 CHEMBL3665471 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CC4CCC3C4)cc21 CHEMBL3665472 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C(F)(F)F)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CC[C@@H](F)C3)cc21 CHEMBL3665473 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CCS(=O)(=O)CC3)cc21 CHEMBL3665475 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(C(F)(F)F)cc3)c(N3CCNC(C(F)(F)F)C3)cc21 CHEMBL3665476 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CC4CCC(C3)O4)cc21 CHEMBL3665479 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2F)nc2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)c(N3CC[C@@H](C(F)(F)F)C3)cc21 CHEMBL3665483 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)F)c2Cl)nc2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)c(N3CCC(F)(F)CC3)cc21 CHEMBL3665485 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)c(N3CCOCC3)cc21 CHEMBL3665486 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)F)c2Cl)nc2cc(C(=O)NCCC(F)(F)F)c(N3CCCC(C(F)(F)F)C3)cc21 CHEMBL3665491 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)F)c2Cl)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(N3CCC(F)(F)C3)cc21 CHEMBL3665492 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C3(C)CC3)c2Cl)nc2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)c(N3CC[C@@H](F)C3)cc21 CHEMBL3665493 IC50 2.0 nM
CC(C)(O)Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665501 IC50 2.0 nM
CC(C)(O)Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)c(N3CCOCC3)cc21 CHEMBL3665502 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)c3cccc[n+]3[O-])c2Cl)nc2cc(C(=O)NCCC(F)(F)F)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665504 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)c3ccc(N)cc3Cl)c2Cl)nc2cc(C(=O)NCCC(F)(F)F)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665507 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)c3c(O)cccc3F)c2Cl)nc2cc(C(=O)NCCC(F)(F)F)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665509 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)c3nccs3)c2Cl)nc2cc(C(=O)NCCC(F)(F)F)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665510 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)F)c2Cl)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665511 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(OCC(F)F)cc21 CHEMBL3694493 IC50 2.0 nM
CC(C)(C)C(=O)NCc1ccc(Cl)c(Nc2nc3cc(OCC(F)F)c(C(=O)N[C@H]4CC[C@H](C(F)(F)F)CC4)cc3[nH]2)c1Cl CHEMBL3694494 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(Br)cc3)c(OCC(F)F)cc21 CHEMBL3694497 IC50 2.0 nM
Cn1c(Nc2c(F)ccc(CNC(=O)C(C)(C)C)c2F)nc2cc(C(=O)Nc3ccc(Br)cc3)c(OCC(F)F)cc21 CHEMBL3694498 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(Br)cc3)c(F)cc21 CHEMBL3694499 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3cc(Cl)ccc3Cl)c(F)cc21 CHEMBL3694513 IC50 2.0 nM
Cn1c(Nc2c(F)ccc(CNC(=O)C(C)(C)C)c2F)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(OCC(F)F)cc21 CHEMBL3694516 IC50 2.0 nM
Cn1c(Nc2c(F)ccc(CNC(=O)C(C)(C)C)c2F)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(OCC(F)F)cc21 CHEMBL3694517 IC50 2.0 nM
Cc1cc(C#N)c(NC(=O)c2cc3nc(Nc4c(Cl)ccc(CNC(=O)C(C)(C)C)c4Cl)n(C)c3cc2OCC(F)F)s1 CHEMBL3694553 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NC3CCC(F)(F)CC3)c(OCC(F)F)cc21 CHEMBL3694555 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3cc(C(F)(F)F)ccn3)c(OCC(F)F)cc21 CHEMBL3694557 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)F)CC3)c(OCC(F)F)cc21 CHEMBL3694558 IC50 2.0 nM
Cn1c(Nc2c(F)ccc(CNC(=O)C(C)(C)C)c2F)nc2cc(C(=O)Nc3cc(F)cc(Cl)c3)c(OCC(F)F)cc21 CHEMBL3694559 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3cccc(Cl)c3F)c(OCC(F)F)cc21 CHEMBL3694562 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2F)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(OCC(F)F)cc21 CHEMBL3694564 IC50 2.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2F)nc2cc(C(=O)NCC(F)(F)F)c(OCC(F)F)cc21 CHEMBL3694566 IC50 2.0 nM
CC(C)(C)C(=O)NCc1ccc(Cl)c(Nc2nc3cc(OC(F)F)c(C(=O)N[C@H]4CC[C@H](C(F)(F)F)CC4)cc3[nH]2)c1Cl CHEMBL3694567 IC50 2.0 nM
CC(C)(C)C(=O)NCc1ccc(Cl)c(Nc2nc3c(F)c(OCC(F)(F)F)c(C(=O)N[C@H]4CC[C@H](C(F)(F)F)CC4)cc3[nH]2)c1Cl CHEMBL3694568 IC50 2.0 nM
CC(C)(C)C(=O)NCc1ccc(Cl)c(Nc2nc3c(F)c(F)c(C(=O)N[C@H]4CC[C@H](C(F)(F)F)CC4)cc3[nH]2)c1Cl CHEMBL3694576 IC50 2.0 nM
COCCCNc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3923054 IC50 2.0 nM
COCc1nc2c(C(=O)Nc3cccc4ccccc34)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3914790 IC50 2.0 nM
O=C(O)c1ccc(Cl)cc1NC[C@@H]1CCC[C@@H]1NC(=O)C1CCN(c2ccccc2)CC1 CHEMBL4067045 IC50 2.0 nM
O=C(O)c1ccc(Cl)cc1OC[C@@H]1CCC[C@@H]1NC(=O)C1CCN(c2ccc(C(F)(F)F)cc2)CC1 CHEMBL4078000 IC50 2.0 nM
O=C(O)c1ccccc1CC[C@@H]1CCC[C@@H]1NC(=O)C1CCN(c2ccc(C(F)(F)F)cc2)CC1 CHEMBL4071976 IC50 2.0 nM
O=C(O)c1ccccc1CC[C@@H]1CCC[C@@H]1NC(=O)C1CCN(c2ccc(C(F)(F)F)cn2)CC1 CHEMBL4063350 IC50 2.0 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(CC(C)C)nc12 CHEMBL3902078 IC50 2.1 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(N3CC[C@H](O)C3)nc12 CHEMBL3981012 IC50 2.1 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C(F)(F)F)c2Cl)nc2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665517 IC50 2.2 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)[C@@](C)(O)C(F)(F)F)c2Cl)nc2cc(C(=O)NC3CC(F)(F)C3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3974284 IC50 2.2 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(C3CCCC3)nc12 CHEMBL3938271 IC50 2.2 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(CC(=O)N3CCCC3)nc12 CHEMBL3961691 IC50 2.2 nM
CNc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3916223 IC50 2.2 nM
COCc1nc2c(C(=O)Nc3cccc4nsnc34)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3976060 IC50 2.2 nM
CC1(C)Cc2c(c(C(=O)NCC3CCCCC3)cc3nc(Nc4c(Cl)cncc4Cl)[nH]c23)O1 CHEMBL4206145 IC50 2.2 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c([C@H]3CCCO3)nc12 CHEMBL4112931 IC50 2.3 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2c(F)cccc2Cl)cc2[nH]c(NCCOC(C)(C)C)nc12 CHEMBL3956169 IC50 2.3 nM
COCc1nc2c(C(=O)Nc3ccccc3Cc3ccccc3)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3910928 IC50 2.3 nM
CC1(C)Cc2c(c(C(=O)NCC3CCCC3)cc3nc(Nc4c(Cl)cccc4Cl)[nH]c23)O1 CHEMBL4207228 IC50 2.3 nM
COCc1nc2c(C(=O)Nc3ccc(C(C)(C)C)cc3)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3928686 IC50 2.4 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(NC[C@H]3CCCO3)nc12 CHEMBL4108273 IC50 2.4 nM
COCCNc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3940802 IC50 2.4 nM
O=c1[nH]c2cc(-c3cccc(Cl)c3)ccc2c2[nH]c(-c3c(F)cccc3Cl)nc12 CHEMBL2387587 IC50 2.5 nM
Cc1ccc(NC(=O)c2cc(NC(=O)c3cc(Cl)ccc3Cl)cc3[nH]c(C4(C)CC4)nc23)cc1Cl CHEMBL3897041 IC50 2.5 nM
COCc1nc2c(C(=O)Nc3nc4ccc(Cl)cc4o3)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3915288 IC50 2.5 nM
COCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3cc(C(F)(F)F)ccc3C(F)(F)F)cc2[nH]1 CHEMBL3956261 IC50 2.6 nM
COCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3cc(F)ccc3C(F)(F)F)cc2[nH]1 CHEMBL3947570 IC50 2.6 nM
Cn1c(Nc2c(F)cccc2Cl)nc2cc(C(=O)Nc3ccc(C(F)(F)F)cc3)c3c(c21)CC(C)(C)O3 CHEMBL3961834 IC50 2.6 nM
CCOc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3918352 IC50 2.7 nM
COCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3c(F)cccc3Br)cc2[nH]1 CHEMBL3946010 IC50 2.8 nM
CC1(C)Cc2c(c(C(=O)Nc3ccc(F)cc3)cc3nc(Nc4c(F)cccc4Cl)[nH]c23)O1 CHEMBL4208718 IC50 2.8 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)[C@@](C)(O)C(F)(F)F)c2Cl)nc2cc(C(=O)Nc3cccc(C(F)(F)F)n3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3892936 IC50 2.9 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(N3CC[C@@H](F)C3)cc21 CHEMBL3665524 IC50 2.9 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C(F)(F)F)c2Cl)nc2cc(C(=O)NCCC(F)(F)F)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665535 IC50 2.9 nM
COCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3c(C)cccc3Cl)cc2[nH]1 CHEMBL3918119 IC50 2.9 nM
Fc1cccc(Cl)c1-c1nc2c3ccc(Br)cc3c3cc(Br)ccc3c2[nH]1 CHEMBL568125 IC50 3.0 nM
CC(C)(O)Cc1ccc2c(c1)c1cc(OCC3CC3)ccc1c1nc(-c3c(C#N)cccc3C#N)[nH]c21 CHEMBL585310 IC50 3.0 nM
CC(C)COc1ccc2c(c1)c1cc(CC(C)(C)O)ccc1c1[nH]c(-c3c(C#N)cccc3C#N)nc21 CHEMBL565617 IC50 3.0 nM
CC(C)NC(=O)N(Cc1cccc(C#Cc2ccccc2)c1)Cc1cccc(-c2ccccc2)c1 CHEMBL1683209 IC50 3.0 nM
CC(C)NC(=O)N(Cc1cccc(C#Cc2ccccc2)c1)Cc1cncc(C#CC2CCCC2)c1 CHEMBL1683212 IC50 3.0 nM
CC(C)NC(=O)N(Cc1cccc(C#Cc2ccc(C(F)(F)F)cc2)c1)Cc1cccc(C#Cc2cccnc2)c1 CHEMBL1683216 IC50 3.0 nM
Cc1ccccc1-c1ccc(-c2ccc3c(c2)c(C)c(CC(C)(C)C(=O)O)n3Cc2ccc(Cl)cc2)cc1F CHEMBL180650 IC50 3.0 nM
Cc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(-c3ccc(-c4ccccc4)c(F)c3)cc12 CHEMBL182032 IC50 3.0 nM
O=C(N[C@H]1CCC[C@H](CO)C1)C1CCN(c2nc3cc(Cl)c(-c4ccc(Cl)cc4)cc3o2)CC1 CHEMBL2325079 IC50 3.0 nM
CC(C)c1ccc2c(c1)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n2Cc1ccc(Cl)cc1 CHEMBL29097 IC50 3.0 nM
CCOc1ccc(-c2cc3oc(N4CCC(C(=O)N[C@H]5CCC[C@H](CO)C5)CC4)nc3cc2Cl)cc1 CHEMBL2391141 IC50 3.0 nM
O=C(N[C@H]1CCC[C@H](CO)C1)C1CCN(c2nc3cc(Cl)c(-c4cccc(Cl)c4)cc3o2)CC1 CHEMBL2391140 IC50 3.0 nM
O=C(N[C@H]1CCC[C@H](CO)C1)C1CCN(c2nc3cc(Cl)c(-c4ccc(F)cc4)cc3o2)CC1 CHEMBL2391299 IC50 3.0 nM
Cn1c(Nc2cc(CNC(=O)C(C)(C)C)ccc2Cl)nc2cc(C(=O)Nc3ccc(Br)cc3)c(OCC(F)F)cc21 CHEMBL3342692 IC50 3.0 nM
CC(C)(C)C(=O)NCc1ccc(Cl)c(C(=O)Nc2ccnc3c(Nc4ccc(C(F)(F)F)cc4)nsc23)c1 CHEMBL3342699 IC50 3.0 nM
CC1(C)CN(c2ccc(C(F)(F)F)cc2)CC[C@@H]1C(=O)N[C@H]1CCC[C@H](CO)C1 CHEMBL3947494 IC50 3.0 nM
CC(C)(C)C(=O)NCc1ccc(Cl)c(Nc2nc3cc(C(=O)NCC(F)(F)F)c(N4CCC(F)CC4)cc3[nH]2)c1Cl CHEMBL3660811 IC50 3.0 nM
Cn1c(Nc2c(F)ccc(CNC(=O)C(C)(C)C)c2F)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CCC(F)CC3)cc21 CHEMBL3660812 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(NCC(F)F)cc21 CHEMBL3660815 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CC[C@H](F)C3)cc21 CHEMBL3660816 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CC[C@@H](F)C3)cc21 CHEMBL3660817 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CCC(F)(F)C3)cc21 CHEMBL3660818 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCC(F)(F)F)c(N3CCC(F)(F)C3)cc21 CHEMBL3660824 IC50 3.0 nM
Cc1nc2c(s1)CN(c1cc3c(cc1C(=O)NCC(F)(F)F)nc(Nc1c(Cl)ccc(CNC(=O)C(C)(C)C)c1Cl)n3C)C2 CHEMBL3660831 IC50 3.0 nM
CN(CCC(F)(F)F)c1cc2c(cc1C(=O)NCC(F)(F)F)nc(Nc1c(Cl)ccc(CNC(=O)C(C)(C)C)c1Cl)n2C CHEMBL3660832 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCc3ncccc3C(F)(F)F)c(N3CCC(F)(F)C3)cc21 CHEMBL3660841 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCCCC(F)(F)F)c(N3CCC(F)(F)C3)cc21 CHEMBL3660844 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCC(F)(F)C(F)(F)F)c(N3CCC(F)(F)C3)cc21 CHEMBL3660848 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2F)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(N3CCC(F)(F)C3)cc21 CHEMBL3660849 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3660850 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NC3(c4ccc(F)cc4)CC3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3660856 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@@H](C(F)(F)F)CC3)c(N3CC4CC4C3)cc21 CHEMBL3660860 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)c(N3CC4CC4C3)cc21 CHEMBL3660861 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(Cl)c(F)c3)c(N3CC4CC4C3)cc21 CHEMBL3660863 IC50 3.0 nM
CC(C)(C)C(=O)NCc1ccc(Cl)c(Nc2nc3cc(C(=O)NCC(F)(F)C(F)(F)F)c(N4CCC(F)(F)CC4)cc3n2CC(F)F)c1Cl CHEMBL3660870 IC50 3.0 nM
CC(C)(C)C(=O)NCc1ccc(Cl)c(Nc2nc3cc(C(=O)Nc4ccc(OC(F)(F)F)cc4)c(N4CC[C@@H](F)C4)cc3n2CC(F)F)c1Cl CHEMBL3660873 IC50 3.0 nM
CC(C)(C)C(=O)NCc1ccc(Cl)c(Nc2nc3cc(C(=O)N[C@H]4CC[C@H](C(F)(F)F)CC4)c(N4CC[C@@H](F)C4)cc3n2CC(F)F)c1Cl CHEMBL3660874 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NC3CCC(C(F)(F)F)CC3)c(N3CCC(O)(C(F)(F)F)CC3)cc21 CHEMBL3948721 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NC3CCC(C(F)(F)F)CC3)c(N3CCC(O)C3)cc21 CHEMBL3943383 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CCC4(CC4)C3)cc21 CHEMBL3660885 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CC4(COC4)C3)cc21 CHEMBL3665446 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CC(F)C3)cc21 CHEMBL3639643 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CCC(C(F)(F)F)C3)cc21 CHEMBL3665452 IC50 3.0 nM
CN(CC#N)c1cc2c(cc1C(=O)N[C@H]1CC[C@H](C(F)(F)F)CC1)nc(Nc1c(Cl)ccc(CNC(=O)C(C)(C)C)c1Cl)n2C CHEMBL3665464 IC50 3.0 nM
Cc1n[nH]c(CN(C)c2cc3c(cc2C(=O)N[C@H]2CC[C@H](C(F)(F)F)CC2)nc(Nc2c(Cl)ccc(CNC(=O)C(C)(C)F)c2Cl)n3C)n1 CHEMBL3665467 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)F)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CC[C@@H](F)C3)cc21 CHEMBL3665469 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CC4CCC4C3)cc21 CHEMBL3665470 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(C(F)(F)F)cc3)c(N3C[C@@H]4C[C@H]3CO4)cc21 CHEMBL3665474 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CCn4ncnc4C3)cc21 CHEMBL3665478 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCCC(F)(F)F)c(N3CC4CC4C3)cc21 CHEMBL3665480 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)c(N3CCCC(C(F)(F)F)C3)cc21 CHEMBL3665481 IC50 3.0 nM
CN(CC(F)F)c1cc2c(cc1C(=O)Nc1ccc(OC(F)(F)F)cc1)nc(Nc1c(Cl)ccc(CNC(=O)C(C)(C)C)c1Cl)n2C CHEMBL3665482 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)c(N3CC[C@H](F)C3)cc21 CHEMBL3665484 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(C(F)(F)F)cc3)c(N3CC[C@@H](F)C3)c(F)c21 CHEMBL3665488 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)F)c2Cl)nc2cc(C(=O)NCCC(F)(F)F)c(N3CCC(O)CC3)cc21 CHEMBL3665489 IC50 3.0 nM
CN(c1cc2c(cc1C(=O)NCCC(F)(F)F)nc(Nc1c(Cl)ccc(CNC(=O)C(C)(C)F)c1Cl)n2C)C1CCC1 CHEMBL3665490 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3cc(C(C)(C)C)on3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665496 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3nc(C(F)(F)F)cs3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665498 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3nnc(C(C)(C)C)s3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665499 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)c3ccc(O)cc3F)c2Cl)nc2cc(C(=O)NCCC(F)(F)F)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665503 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)[C@@](C)(O)C(F)(F)F)c2Cl)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(N3CC[C@@H](F)C3)cc21 CHEMBL3903757 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2F)nc2cc(C(=O)Nc3ccc(Br)cc3)c(OCC(F)F)cc21 CHEMBL3694500 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)OC(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(OCC(F)F)cc21 CHEMBL3694505 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)OC(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(OCC(F)F)cc21 CHEMBL3694506 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NC3CC(F)(F)C3)c(F)cc21 CHEMBL3694511 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCC(F)(F)F)c(F)cc21 CHEMBL3694512 IC50 3.0 nM
CC(C)(C)C(=O)NCc1ccc(F)c(Nc2nc3cc(F)c(C(=O)Nc4ccc(F)c(Cl)c4)cc3[nH]2)c1F CHEMBL3694515 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3cccc(C#N)c3)c(OCC(F)F)cc21 CHEMBL3694519 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3cccc(F)c3)c(OCC(F)F)cc21 CHEMBL3694522 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NC3CCC3)c(OCC(F)F)cc21 CHEMBL3694523 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCC(F)(F)C(F)(F)F)c(OCC(F)F)cc21 CHEMBL3694529 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCC3CC3(Cl)Cl)c(OCC(F)F)cc21 CHEMBL3694535 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCC3CCC3)c(OCC(F)F)cc21 CHEMBL3694537 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(C(F)(F)F)nc3)c(OCC(F)F)cc21 CHEMBL3694538 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCCC(F)(F)F)c(OCC(F)F)cc21 CHEMBL3694539 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCCC3CC3)c(OCC(F)F)cc21 CHEMBL3694542 IC50 3.0 nM
Cc1ccc(Cl)cc1NC(=O)c1cc2nc(Nc3c(Cl)ccc(CNC(=O)C(C)(C)C)c3Cl)n(C)c2cc1OCC(F)F CHEMBL3694545 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCC(F)(F)F)c(OCC(F)F)cc21 CHEMBL3694549 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(Cl)cc3Cl)c(OCC(F)F)cc21 CHEMBL3694551 IC50 3.0 nM
Cc1cc(Cl)cnc1NC(=O)c1cc2nc(Nc3c(Cl)ccc(CNC(=O)C(C)(C)C)c3Cl)n(C)c2cc1OCC(F)F CHEMBL3694554 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2F)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(OCC(F)F)cc21 CHEMBL3694565 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)N3CCC(F)(F)C3)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(OCC(F)F)cc21 CHEMBL3694570 IC50 3.0 nM
COCc1nc2c(C(=O)Nc3ccc4c(c3)CCC4)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3955303 IC50 3.0 nM
O=C(O)c1ccc(Cl)cc1NC[C@@H]1CCC[C@@H]1NC(=O)C1CCN(c2ccc(C(F)(F)F)cc2)CC1 CHEMBL4094518 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(Cl)cc3F)c(OCC(F)F)cc21 CHEMBL3694524 IC50 3.0 nM
CC1(C)Cc2c(c(C(=O)Nc3cc(C(F)(F)F)ccc3F)cc3nc(Nc4c(F)cccc4Cl)[nH]c23)O1 CHEMBL4228804 IC50 3.0 nM
Cn1c(Nc2c(F)cccc2Cl)nc2cc(C(=O)Nc3cccc(C(F)(F)F)c3)c3c(c21)CC(C)(C)O3 CHEMBL4228430 IC50 3.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)[C@](C)(O)C(F)(F)F)c2Cl)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3947954 IC50 3.1 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C(F)(F)F)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@@H](C(F)(F)F)CC3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665530 IC50 3.1 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(NCCN3CCOCC3)nc12 CHEMBL3918491 IC50 3.1 nM
CC1(C)Cc2c(c(C(=O)Nc3ccc(C(F)(F)F)cc3F)cc3nc(Nc4c(F)cccc4Cl)[nH]c23)O1 CHEMBL4227545 IC50 3.1 nM
Cc1ccc(NC(=O)c2cc3nc(Nc4c(F)cccc4Cl)n(C)c3c3c2OC(C)(C)C3)c(F)c1 CHEMBL4227388 IC50 3.1 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(C3CN(C(=O)OC(C)(C)C)C3)nc12 CHEMBL3932321 IC50 3.2 nM
COC1CN(c2nc3c(C(=O)Nc4cccc(Cl)c4C)cc(NC(=O)c4ccccc4C(F)(F)F)cc3[nH]2)C1 CHEMBL3976835 IC50 3.2 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(NC[C@@H]3CCCO3)nc12 CHEMBL3928327 IC50 3.2 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(N[C@H](CO)C(C)C)nc12 CHEMBL4113493 IC50 3.2 nM
Cc1ccc(NC(=O)c2cc(NC(=O)c3c(Cl)cccc3Cl)cc3[nH]c(N(C)C)nc23)cc1Cl CHEMBL3938942 IC50 3.2 nM
CC1(C)Cc2c(c(C(=O)Nc3cc(C4CC4)ccc3F)cc3nc(Nc4c(Cl)cccc4Cl)[nH]c23)O1 CHEMBL4226536 IC50 3.2 nM
O=c1[nH]c2cc(-c3ccc(Cl)cc3)ccc2c2[nH]c(-c3c(F)cccc3Cl)nc12 CHEMBL2387588 IC50 3.3 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C(F)(F)F)c2Cl)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(N3CC[C@@H](F)C3)cc21 CHEMBL3665515 IC50 3.3 nM
COCc1nc2c(C(=O)Nc3ccc(C(F)(F)F)cc3)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3964550 IC50 3.3 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(NCCO)nc12 CHEMBL3973716 IC50 3.3 nM
Cc1cccc(Cl)c1Nc1nc2cc(C(=O)Nc3cc(C(F)(F)F)ccc3F)c3c(c2[nH]1)CC(C)(C)O3 CHEMBL4226545 IC50 3.3 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)F)c2Cl)nc2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)c(N3CC[C@@H](F)C3)cc21 CHEMBL3665518 IC50 3.5 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)c(N3CC[C@@H](F)C3)cc21 CHEMBL3665520 IC50 3.5 nM
COCc1nc2c(C(=O)Nc3ccc(C)cc3C)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3971711 IC50 3.5 nM
COCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3cc(OCCOC(C)C)ccc3Cl)cc2[nH]1 CHEMBL3946547 IC50 3.5 nM
CC1(C)Cc2c(c(C(=O)Nc3ccc(F)cc3)cc3nc(Nc4c(Cl)cccc4Cl)[nH]c23)O1 CHEMBL4203842 IC50 3.5 nM
O=C(Nc1ccc(C#CC2CC2)c(F)c1)c1cc2nc(Nc3c(F)cccc3Cl)[nH]c2c2c1OCCO2 CHEMBL3916119 IC50 3.56 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(NCCOC(C)C)nc12 CHEMBL3950781 IC50 3.6 nM
CSc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3926265 IC50 3.6 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2c(Cl)cccc2Br)cc2[nH]c(N(C)C)nc12 CHEMBL3901262 IC50 3.6 nM
Cc1ccc(NC(=O)c2cc(NC(=O)c3cc(Cl)ccc3Cl)cc3[nH]c(N(C)C)nc23)cc1Cl CHEMBL3968493 IC50 3.6 nM
CC1(C)Cc2c(c(C(=O)Nc3cc(C4CC4)ccc3F)cc3nc(Nc4c(F)cccc4Cl)[nH]c23)O1 CHEMBL4225183 IC50 3.6 nM
COCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3cc(Cl)ccc3Cl)cc2[nH]1 CHEMBL3931645 IC50 3.7 nM
Cc1ccc(NC(=O)c2cc(NC(=O)c3c(F)cccc3Cl)cc3[nH]c(N(C)C)nc23)cc1Cl CHEMBL3976999 IC50 3.7 nM
CC1(C)Cc2c(c(C(=O)Nc3ccc(C(F)(F)F)cc3)cc3nc(Nc4c(Cl)cccc4Cl)[nH]c23)O1 CHEMBL4206581 IC50 3.7 nM
CC1(C)Cc2c(c(C(=O)Nc3ccc(C(F)(F)F)cc3F)cc3nc(Nc4c(Cl)cncc4Cl)[nH]c23)O1 CHEMBL4210425 IC50 3.7 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3cccc(C(F)(F)F)n3)c(N3CC[C@@H](F)C3)cc21 CHEMBL3665523 IC50 3.8 nM
Cc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3939684 IC50 3.8 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(NCC(=O)O)nc12 CHEMBL3892485 IC50 3.8 nM
CC1(C)Oc2cc(C#Cc3cc(C(F)(F)F)ccc3Cl)ccc2-c2nc(-c3c(C#N)cccc3C#N)[nH]c21 CHEMBL4076884 IC50 3.89 nM
CC1(C)Cc2c(c(C(=O)Nc3ccc(C(F)(F)F)cc3)cc3nc(Nc4c(F)cccc4Cl)[nH]c23)O1 CHEMBL3931344 IC50 3.9 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)[C@@](C)(O)C(F)(F)F)c2Cl)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3980304 IC50 3.9 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)F)c2Cl)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(N3CC[C@@H](F)C3)cc21 CHEMBL3665514 IC50 3.9 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)[C@@](C)(O)C(F)(F)F)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3930681 IC50 3.9 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)F)c2Cl)nc2cc(C(=O)NC3CC(F)(F)C3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665531 IC50 3.9 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(N)nc12 CHEMBL3953129 IC50 3.9 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c([C@@H]3CCC(=O)N3)nc12 CHEMBL3949570 IC50 3.9 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2cc(Cl)ccc2Cl)cc2[nH]c(NCC(C)(C)O)nc12 CHEMBL3951950 IC50 3.9 nM
CC(=O)c1ccccc1-c1cc2c(C)c(CC(C)(C)C(=O)O)n(Cc3ccc(Cl)cc3)c2cc1F CHEMBL3770554 pIC50 3.981 nM
CC(C)c1ccc2c(c1)c1cc(Br)ccc1c1nc(-c3c(F)cccc3Cl)[nH]c21 CHEMBL585110 IC50 4.0 nM
CC(C)(O)c1ccc2c(c1)c1cc(Cl)ccc1c1nc(-c3c(C#N)cccc3C#N)[nH]c21 CHEMBL584930 IC50 4.0 nM
Cc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(-c3ccc(-c4ccccc4Cl)c(F)c3)cc12 CHEMBL180617 IC50 4.0 nM
COc1ccc(-c2nnc(SCC(=O)c3ccc4c(c3)Cc3ccccc3-4)nc2-c2ccc(OC)cc2)cc1 CHEMBL2336515 IC50 4.0 nM
CC(C)C(=O)NCc1cnc(C(F)F)c(-c2nc3cc(-c4ccc(C(F)(F)F)cc4)ncc3c(=O)[nH]2)c1 CHEMBL3342851 IC50 4.0 nM
Fc1cccc(Cl)c1-c1nc(-c2ccc(C#Cc3cccc(Cl)c3)nc2)c[nH]1 CHEMBL1289055 IC50 4.0 nM
CC1(C)CN(c2ccc3cccc(Cl)c3n2)CC[C@@H]1C(=O)N[C@H]1CC[C@@H](CO)CC1 CHEMBL3922684 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2F)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CCC(C(F)(F)F)C3)cc21 CHEMBL3660809 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(NC3CC(F)(F)C3)cc21 CHEMBL3660814 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CC(F)(F)C3)cc21 CHEMBL3660819 IC50 4.0 nM
CN(c1cc2c(cc1C(=O)NCC(F)(F)F)nc(Nc1c(Cl)ccc(CNC(=O)C(C)(C)C)c1Cl)n2C)C1CC1 CHEMBL3660821 IC50 4.0 nM
CN1CCN(c2cc3c(cc2C(=O)N[C@H]2CC[C@H](C(F)(F)F)CC2)nc(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)n3C)CC1=O CHEMBL3660823 IC50 4.0 nM
CN(c1ccc(F)c(Cl)c1)c1cc2c(cc1C(=O)NCC(F)(F)F)nc(Nc1c(Cl)ccc(CNC(=O)C(C)(C)C)c1Cl)n2C CHEMBL3660829 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NC(c3ccccn3)C(F)(F)F)c(N3CCC(F)(F)C3)cc21 CHEMBL3660836 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCc3ccc(F)cc3C(F)(F)F)c(N3CCC(F)(F)C3)cc21 CHEMBL3660842 IC50 4.0 nM
CC(C)C(NC(=O)c1cc2nc(Nc3c(Cl)ccc(CNC(=O)C(C)(C)C)c3Cl)n(C)c2cc1N1CCC(F)(F)C1)C(F)(F)F CHEMBL3660847 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NC3CCN(CC(F)(F)F)CC3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3660857 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CCOCC3)cc21 CHEMBL3660864 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCC(F)(F)C(F)(F)F)c(N3CCOCC3)cc21 CHEMBL3660865 IC50 4.0 nM
CC(C)(C)C(=O)NCc1ccc(Cl)c(Nc2nc3cc(C(=O)NCC(F)(F)C(F)(F)F)c(N4CCOCC4)cc3n2CC(F)F)c1Cl CHEMBL3660869 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCCC(F)(F)F)c(N3CCCC(C(F)(F)F)C3)cc21 CHEMBL3660876 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CC(C)(O)C3)cc21 CHEMBL3660881 IC50 4.0 nM
CN(c1cc2c(cc1C(=O)N[C@H]1CC[C@H](C(F)(F)F)CC1)nc(Nc1c(Cl)ccc(CNC(=O)C(C)(C)C)c1Cl)n2C)C1CCC1 CHEMBL3660886 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CC4(CCC4)C3)cc21 CHEMBL3665447 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3cc(C(C)(C)C)no3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665494 IC50 4.0 nM
Cc1nc(C(F)(F)F)c(CNC(=O)c2cc3nc(Nc4c(Cl)ccc(CNC(=O)C(C)(C)C)c4Cl)n(C)c3cc2N2CCC(C(F)(F)F)CC2)s1 CHEMBL3665495 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3cc(C(C)(C)CO)no3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665497 IC50 4.0 nM
CC(C)(C)C(=O)NCc1ccc(Cl)c(Nc2nc3cc(C(=O)N[C@H]4CC[C@H](C(F)(F)F)CC4)c(N4CC5CC5C4)cc3n2C2(C(C)(C)O)CC2)c1Cl CHEMBL3665500 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)CO)c2Cl)nc2cc(C(=O)NCCC(F)(F)F)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665505 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)c3c(N)cccc3Cl)c2Cl)nc2cc(C(=O)NCCC(F)(F)F)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665506 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)F)c2Cl)nc2cc(C(=O)NCCC(F)(F)F)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665534 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(F)cc21 CHEMBL3694495 IC50 4.0 nM
CC(C)(C)C(=O)NCc1ccc(Cl)c(Nc2nc3cc(OCC(F)F)c(C(=O)Nc4ccc(Br)cc4)cc3[nH]2)c1Cl CHEMBL3694496 IC50 4.0 nM
Cn1c(Nc2c(F)ccc(CNC(=O)C(C)(C)C)c2F)nc2cc(C(=O)Nc3ccc(Br)cc3)c(F)cc21 CHEMBL3694501 IC50 4.0 nM
CC(C)(C)C(=O)NCc1ccc(F)c(Nc2nc3cc(C(=O)Nc4ccc(Br)cc4)c(OCC(F)F)cc3n2C2CC2)c1F CHEMBL3694503 IC50 4.0 nM
CC(C)(C)C(=O)NCc1ccc(Cl)c(Nc2nc3cc(F)c(C(=O)N[C@H]4CC[C@H](C(F)(F)F)CC4)cc3[nH]2)c1Cl CHEMBL3694504 IC50 4.0 nM
Cn1c(Nc2c(F)ccc(CNC(=O)C(C)(C)C)c2F)nc2cc(C(=O)NCC(F)(F)F)c(OCC(F)F)cc21 CHEMBL3694518 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(OCC(F)F)cc21 CHEMBL3694520 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3cccc(Cl)c3)c(OCC(F)F)cc21 CHEMBL3694521 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3nc4ccc(Cl)cc4s3)c(OCC(F)F)cc21 CHEMBL3694525 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCc3ccccc3C(F)(F)F)c(OCC(F)F)cc21 CHEMBL3694526 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCc3ccc(F)cc3C(F)(F)F)c(OCC(F)F)cc21 CHEMBL3694527 IC50 4.0 nM
CC(NC(=O)c1cc2nc(Nc3c(Cl)ccc(CNC(=O)C(C)(C)C)c3Cl)n(C)c2cc1OCC(F)F)C(F)(F)F CHEMBL3694530 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3cc(F)cc(Cl)c3)c(OCC(F)F)cc21 CHEMBL3694531 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ncc(Cl)s3)c(OCC(F)F)cc21 CHEMBL3694532 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCc3ncccc3C(F)(F)F)c(OCC(F)F)cc21 CHEMBL3694533 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCC(F)F)c(OCC(F)F)cc21 CHEMBL3694534 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(Cl)c(F)c3)c(OCC(F)F)cc21 CHEMBL3694536 IC50 4.0 nM
COCC1(CNC(=O)c2cc3nc(Nc4c(Cl)ccc(CNC(=O)C(C)(C)C)c4Cl)n(C)c3cc2OCC(F)F)CCCC1 CHEMBL3694540 IC50 4.0 nM
COC(=O)c1ccc(NC(=O)c2cc3nc(Nc4c(Cl)ccc(CNC(=O)C(C)(C)C)c4Cl)n(C)c3cc2OCC(F)F)s1 CHEMBL3694541 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCC3CCCCC3)c(OCC(F)F)cc21 CHEMBL3694543 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCC3CC3)c(OCC(F)F)cc21 CHEMBL3694544 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NC3CC4CCC3C4)c(OCC(F)F)cc21 CHEMBL3694546 IC50 4.0 nM
CCNC(=O)c1cc2nc(Nc3c(Cl)ccc(CNC(=O)C(C)(C)C)c3Cl)n(C)c2cc1OCC(F)F CHEMBL3694547 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCCc3ccccc3)c(OCC(F)F)cc21 CHEMBL3694548 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc4c(c3)CCC4)c(OCC(F)F)cc21 CHEMBL3694550 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(C(F)(F)F)cn3)c(OCC(F)F)cc21 CHEMBL3694552 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccncc3Cl)c(OCC(F)F)cc21 CHEMBL3639934 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3cccc(C(F)(F)F)n3)c(OCC(F)F)cc21 CHEMBL3694556 IC50 4.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3nc(C(F)(F)F)cs3)c(F)cc21 CHEMBL3694560 IC50 4.0 nM
Cn1c(Nc2c(F)cccc2Cl)nc2cc(C(=O)Nc3ccc(C(F)(F)F)cn3)c3c(c21)CC(C)(C)O3 CHEMBL4225710 IC50 4.0 nM
O=c1[nH]c2cc(-c3ccccc3)ccc2c2[nH]c(-c3c(F)cccc3Cl)nc12 CHEMBL2387503 IC50 4.1 nM
COCc1nc2c(C(=O)Nc3ccc(C)c(C)c3)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3950701 IC50 4.1 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(CC(N)=O)nc12 CHEMBL3960593 IC50 4.1 nM
CC1(C)Cc2c(c(C(=O)Nc3ccccc3)cc3nc(Nc4c(Cl)cccc4Cl)[nH]c23)O1 CHEMBL4204420 IC50 4.1 nM
CC1(C)Cc2c(c(C(=O)Nc3ccc(C(F)(F)F)cn3)cc3nc(Nc4c(Cl)cccc4Cl)[nH]c23)O1 CHEMBL4229061 IC50 4.1 nM
Cn1c(Nc2c(F)cccc2Cl)nc2cc(C(=O)Nc3ccc(C#CC4CC4)c(F)c3)c3c(c21)OCCO3 CHEMBL3944077 IC50 4.19 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)[C@](C)(O)C(F)(F)F)c2Cl)nc2cc(C(=O)Nc3cccc(C(F)(F)F)n3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3904157 IC50 4.2 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)F)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665527 IC50 4.2 nM
COCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3ccc(F)cc3Cl)cc2[nH]1 CHEMBL3890398 IC50 4.2 nM
CC1(C)Cc2c(c(C(=O)Nc3ccc(C4CCCCC4)cc3)cc3nc(Nc4c(F)cccc4Cl)[nH]c23)O1 CHEMBL4213901 IC50 4.2 nM
O=c1[nH]c2cc(-c3ccccc3Cl)ccc2c2[nH]c(-c3c(F)cccc3Cl)nc12 CHEMBL2387507 IC50 4.3 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)[C@](C)(O)C(F)(F)F)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3931697 IC50 4.3 nM
Cn1c(Nc2c(F)cccc2Cl)nc2cc(C(=O)Nc3ccc(C4CC4)cc3)c3c(c21)CC(C)(C)O3 CHEMBL4225160 IC50 4.3 nM
Cc1cccc(-c2ccc3c(c2)[nH]c(=O)c2nc(-c4c(F)cccc4Cl)[nH]c23)c1 CHEMBL2387505 IC50 4.5 nM
COCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3cc(Br)ccc3Cl)cc2[nH]1 CHEMBL3930591 IC50 4.5 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(N[C@H](CO)C(C)(C)C)nc12 CHEMBL4108723 IC50 4.5 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2cc(Cl)ccc2Cl)cc2[nH]c(N(C)C)nc12 CHEMBL3959403 IC50 4.5 nM
Cc1cc(C)c2oc(-c3ccc(C)c(NC(=O)c4cccc([N+](=O)[O-])c4)c3)nc2c1 CHEMBL2336519 IC50 4.6 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c([C@H]3CCCN3C(=O)OC(C)(C)C)nc12 CHEMBL4114354 IC50 4.6 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2c(F)cccc2Cl)cc2[nH]c(NCC(C)(C)CO)nc12 CHEMBL3901839 IC50 4.6 nM
Cc1cc2c(o1)c(C(=O)Nc1cccc(C(F)(F)F)c1)cc1nc(Nc3c(Cl)cccc3Cl)[nH]c12 CHEMBL4211033 IC50 4.6 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(N[C@@H](CO)C(C)C)nc12 CHEMBL3908664 IC50 4.7 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2cc(Cl)ccc2Cl)cc2[nH]c(C3(C)CC3)nc12 CHEMBL3925094 IC50 4.7 nM
CC1(C)Cc2c(c(C(=O)Nc3ccc(F)c(C(F)(F)F)c3)cc3nc(Nc4c(Cl)cncc4Cl)[nH]c23)O1 CHEMBL4204099 IC50 4.7 nM
COCc1nc2c(C(=O)Nc3ccccc3C)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3976325 IC50 4.8 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C(F)(F)F)c2Cl)nc2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)c(N3CC[C@@H](F)C3)cc21 CHEMBL3665519 IC50 4.9 nM
COCc1nc2c(C(=O)Nc3cccc4c3CCCC4)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3927687 IC50 4.9 nM
NC(=O)Cc1nc2c(C(=O)NCc3ccccc3C(F)(F)F)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3938616 IC50 4.9 nM
Cc1ccc(NC(=O)c2cc(NC(=O)c3ccccc3C(F)(F)F)cc3[nH]c(N(C)C)nc23)cc1Cl CHEMBL3896359 IC50 4.9 nM
CC1(C)Cc2c(c(C(=O)Nc3ccccc3C(F)(F)F)cc3nc(Nc4c(Cl)cccc4Cl)[nH]c23)O1 CHEMBL4225008 IC50 4.9 nM
Fc1cccc(Cl)c1-c1nc2c3ccc(Cl)cc3c3ccccc3c2[nH]1 CHEMBL568545 IC50 5.0 nM
CC(C)C(=O)NCc1ccc(Cl)c(-c2nc3cc(-c4ccc(C(F)(F)F)cc4)ncc3c(=O)[nH]2)c1 CHEMBL3342849 IC50 5.0 nM
CC(C)(C)C(=O)NCc1ccc(Cl)c(C(=O)Nc2ccc3cnn(-c4ccc(C(F)(F)F)cc4)c(=O)c3c2)c1 CHEMBL3342700 IC50 5.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(NC3CC(F)(F)C3)cc21 CHEMBL3660807 IC50 5.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CC4CC4C3)cc21 CHEMBL3660820 IC50 5.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CCn4cncc4C3)cc21 CHEMBL3660822 IC50 5.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCC(F)(F)F)c(Nc3ccc(F)c(Cl)c3)cc21 CHEMBL3660828 IC50 5.0 nM
CC(NC(=O)c1cc2nc(Nc3c(Cl)ccc(CNC(=O)C(C)(C)C)c3Cl)n(C)c2cc1N1CCC(F)(F)C1)c1cccs1 CHEMBL3660834 IC50 5.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NC3(c4ccc(F)cc4)CC3)c(N3CCC(F)(F)C3)cc21 CHEMBL3660835 IC50 5.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCC3CC3)c(N3CCC(F)(F)C3)cc21 CHEMBL3660843 IC50 5.0 nM
COC1CN(c2cc3c(cc2C(=O)N[C@H]2CC[C@H](C(F)(F)F)CC2)nc(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)n3C)C1 CHEMBL3665450 IC50 5.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(N3CCN(CC(F)(F)F)CC3)cc21 CHEMBL3665477 IC50 5.0 nM
Cc1c(N2CC3CC3C2)c(C(=O)Nc2ccc(C(F)(F)F)cc2)cc2nc(Nc3c(Cl)ccc(CNC(=O)C(C)(C)C)c3Cl)n(C)c12 CHEMBL3665487 IC50 5.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)c3cccc(O)c3)c2Cl)nc2cc(C(=O)NCCC(F)(F)F)c(N3CCC(C(F)(F)F)CC3)cc21 CHEMBL3665508 IC50 5.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)OC(C)(C)C)c2Cl)nc2cc(C(=O)NCC(F)(F)F)c(OCC(F)F)cc21 CHEMBL3694507 IC50 5.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)NCC3CCCO3)c(OCC(F)F)cc21 CHEMBL3694528 IC50 5.0 nM
COCCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3946870 IC50 5.0 nM
CC1(C)Cc2c(c(C(=O)Nc3ccc(F)c(C(F)(F)F)c3)cc3nc(Nc4c(F)cccc4Cl)[nH]c23)O1 CHEMBL4224969 IC50 5.0 nM
Cc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2cc(F)c(-c3ccccc3Cl)cc12 CHEMBL3769475 pIC50 5.012 nM
COCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3ccccc3Cl)cc2[nH]1 CHEMBL3979720 IC50 5.1 nM
CC1(C)Cc2c(c(C(=O)Nc3ccccc3C(F)(F)F)cc3nc(Nc4c(F)cccc4Cl)[nH]c23)O1 CHEMBL4224733 IC50 5.1 nM
COCc1nc2c(C(=O)Nc3ccc(C)c(Cl)c3)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3926511 IC50 5.2 nM
COC(C)(C)CNc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3c(F)cccc3Cl)cc2[nH]1 CHEMBL3902791 IC50 5.2 nM
COCc1nc2c(C(=O)Nc3ccccc3)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3969919 IC50 5.2 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(N3CCN(C)CC3)nc12 CHEMBL3967246 IC50 5.3 nM
COCc1nc2c(C(=O)NCC3CCCCC3)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3986933 IC50 5.3 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(CN(C)C)nc12 CHEMBL3986877 IC50 5.4 nM
Cc1cccc(Cl)c1Nc1nc2cc(C(=O)Nc3ccc(F)c(C(F)(F)F)c3)c3c(c2[nH]1)CC(C)(C)O3 CHEMBL4226526 IC50 5.4 nM
COCc1nc2c(C(=O)NC3CCCCC3)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3928690 IC50 5.6 nM
CC(=O)OCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3951390 IC50 5.6 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2c(F)cccc2Cl)cc2[nH]c(C3CCCC3)nc12 CHEMBL3929235 IC50 5.6 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2cc(Cl)ccc2Cl)cc2[nH]c(C(C)(C)C)nc12 CHEMBL3978391 IC50 5.7 nM
CC1(C)Cc2c(c(C(=O)Nc3ccc(C(F)(F)F)cc3)cc3nc(Nc4c(Cl)cncc4Cl)[nH]c23)O1 CHEMBL4218836 IC50 5.8 nM
COCC(C)(C)CNc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3908122 IC50 5.9 nM
COc1ccc2c(c1)c1cc(Br)ccc1c1nc(-c3c(F)cccc3Cl)[nH]c21 CHEMBL566446 IC50 6.0 nM
CC(C)c1cc2oc(N3CCC(C(=O)N[C@H]4CCC[C@H](CO)C4)CC3)nc2cc1Cl CHEMBL2391295 IC50 6.0 nM
CC(C)C(=O)NCc1cnc(C(F)F)c(-c2nc3cc(-c4ccc(C(F)(F)F)cc4)ccc3c(=O)[nH]2)c1 CHEMBL3342848 IC50 6.0 nM
Cc1cccc2ccc(N3CC[C@H](C(=O)N[C@H]4CCOC4)C(C)(C)C3)nc12 CHEMBL3926051 IC50 6.0 nM
COCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3c(Cl)cccc3Cl)cc2[nH]1 CHEMBL3944352 IC50 6.0 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2c(F)cccc2Cl)cc2[nH]c(NC[C@@H]3CCCO3)nc12 CHEMBL3895736 IC50 6.0 nM
O=C(O)c1cccnc1CC[C@@H]1CCC[C@@H]1NC(=O)C1CCN(c2ccc(C(F)(F)F)cc2)CC1 CHEMBL4092750 IC50 6.0 nM
Cc1cc(C(F)(F)F)ccc1NC(=O)c1cc2nc(Nc3c(F)cccc3Cl)[nH]c2c2c1OC(C)(C)C2 CHEMBL4227610 IC50 6.0 nM
COCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3ccccc3Br)cc2[nH]1 CHEMBL3970455 IC50 6.1 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2c(F)cccc2Br)cc2[nH]c(N(C)C)nc12 CHEMBL3925798 IC50 6.1 nM
CC1(C)Cc2c(c(C(=O)NCC(F)(F)C(F)(F)F)cc3nc(Nc4c(Cl)cccc4Cl)[nH]c23)O1 CHEMBL4203493 IC50 6.2 nM
CCOCCOCc1ccc(Cl)c(C(=O)Nc2cc(C(=O)Nc3cccc(Cl)c3C)c3nc(COC)[nH]c3c2)c1 CHEMBL3961176 IC50 6.3 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2c(F)cccc2Cl)cc2[nH]c([C@H]3CCCO3)nc12 CHEMBL4109733 IC50 6.3 nM
CC1(C)Cc2c(c(C(=O)NC3CCCCC3)cc3nc(Nc4c(Cl)cncc4Cl)[nH]c23)O1 CHEMBL4218250 IC50 6.3 nM
CC1(C)Cc2c(c(C(=O)Nc3cc(C(F)F)ccc3F)cc3nc(Nc4c(F)cccc4Cl)[nH]c23)O1 CHEMBL4226379 IC50 6.3 nM
CC1(C)Cc2c(c(C(=O)Nc3c(F)cccc3F)cc3nc(Nc4c(Cl)cccc4Cl)[nH]c23)O1 CHEMBL4226878 IC50 6.4 nM
Clc1ccc(/C=C/c2cc(-c3ccc(-c4ccccc4)cc3)nc3ccc4ccccc4c23)cc1 CHEMBL2336521 IC50 6.5 nM
COCC(C)(C)CNc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3c(F)cccc3Cl)cc2[nH]1 CHEMBL3912512 IC50 6.5 nM
Cc1cc2c(o1)c(C(=O)Nc1ccc(C(F)(F)F)cc1)cc1nc(Nc3c(Cl)cncc3Cl)[nH]c12 CHEMBL4206169 IC50 6.5 nM
Cn1c(Nc2c(F)cccc2Cl)nc2cc(C(=O)Nc3ccc(C(F)(F)F)cc3)c3c(c21)OCCO3 CHEMBL3926181 IC50 6.59 nM
COCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3934885 IC50 6.6 nM
COCc1nc2c(C(=O)Nc3cccc(Br)c3C)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3917360 IC50 6.6 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)O)c2Cl)nc2cc(C(=O)Nc3ccc(F)c(Cl)c3)c(N3CC[C@@H](F)C3)cc21 CHEMBL3665526 IC50 6.7 nM
COCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3c(F)cccc3Cl)cc2[nH]1 CHEMBL3967154 IC50 6.7 nM
COc1ccc(NC(=O)c2cc3nc(Nc4c(Cl)cccc4Cl)[nH]c3c3c2OC(C)(C)C3)cn1 CHEMBL4206064 IC50 6.7 nM
COc1ccccc1-c1cc2c(C)c(CC(C)(C)C(=O)O)n(Cc3ccc(Cl)cc3)c2cc1F CHEMBL3770829 pIC50 6.918 nM
CC(C)(O)c1ccc2c(c1)c1cc(Br)ccc1c1nc(-c3c(F)cccc3Cl)[nH]c21 CHEMBL566262 IC50 7.0 nM
Cc1ccc2c(c1)c1cc(C)ccc1c1[nH]c(-c3c(F)cccc3Cl)nc21 CHEMBL585486 IC50 7.0 nM
CC(C)C(=O)NCc1ccc(Cl)c(-c2nc3cc(-c4ccc(C(F)(F)F)cc4)ccc3c(=O)[nH]2)c1 CHEMBL3342712 IC50 7.0 nM
Cc1cccc2ccc(N3CC[C@H](C(=O)N[C@H]4CCCOC4)C(C)(C)C3)nc12 CHEMBL3910746 IC50 7.0 nM
Cn1c(Nc2c(F)ccc(CNC(=O)C(C)(C)C)c2F)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(F)cc21 CHEMBL3694502 IC50 7.0 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(CC(=O)N(C)C)nc12 CHEMBL3986920 IC50 7.0 nM
Cc1nc2c(C(=O)NCc3ccccc3C(F)(F)F)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3901194 IC50 7.1 nM
Cn1c(Nc2c(F)cccc2Cl)nc2cc(C(=O)NC3CCC(C)(C)CC3)c3c(c21)OCCO3 CHEMBL3984373 IC50 7.2 nM
COCc1nc2c(C(=O)Nc3ccc(C)cc3)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3921204 IC50 7.2 nM
COCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3cc(CCCOC(C)(C)C)ccc3Cl)cc2[nH]1 CHEMBL3960532 IC50 7.3 nM
O=C(N[C@H]1CCC[C@@H]1OCc1ccccc1)C1CCN(c2nc3cc(Cl)ccc3o2)CC1 CHEMBL2315853 IC50 7.5 nM
CCOc1nc2c(C(=O)NCc3ccccc3C(F)(F)F)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3963133 IC50 7.5 nM
O=C(Nc1cc(C(=O)NC2CCCCC2)c2nc[nH]c2c1)c1ccccc1C(F)(F)F CHEMBL3981975 IC50 7.6 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(NCC(=O)OC(C)(C)C)nc12 CHEMBL3895259 IC50 7.6 nM
COCc1nc2c(C(=O)Nc3nc4ccccc4o3)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3943251 IC50 7.7 nM
CC1(C)Cc2c(c(C(=O)Nc3cccc(C4CCCCC4)c3)cc3nc(Nc4c(F)cccc4Cl)[nH]c23)O1 CHEMBL4209884 IC50 7.7 nM
CC1(C)Oc2cc(C#Cc3ccc(Cl)cc3C(F)(F)F)ccc2-c2nc(-c3c(F)cccc3Cl)[nH]c21 CHEMBL4081143 IC50 7.76 nM
COCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3cc(C)ccc3C(F)(F)F)cc2[nH]1 CHEMBL3925241 IC50 7.8 nM
O=c1[nH]c2cc(-c3ccccc3)ccc2c2[nH]c(-c3ccccc3Cl)nc12 CHEMBL2387599 IC50 7.9 nM
Cn1c(Nc2c(F)cccc2Cl)nc2cc(C(=O)Nc3ccc(F)c(C(F)(F)F)c3)c3c(c21)OCCO3 CHEMBL3898125 IC50 7.99 nM
Fc1cccc(Cl)c1-c1nc2c3cccc(Br)c3c3ccccc3c2[nH]1 CHEMBL566261 IC50 8.0 nM
CC(=O)c1ccc2c(c1)c1cc(Br)ccc1c1nc(-c3c(F)cccc3Cl)[nH]c21 CHEMBL568576 IC50 8.0 nM
CC(C)NC(=O)N(Cc1ccccc1)Cc1cccc(C#Cc2ccccc2)c1 CHEMBL1683197 IC50 8.0 nM
CCCNC(=O)N(Cc1ccccc1)Cc1cccc(C#Cc2ccccc2)c1 CHEMBL1683220 IC50 8.0 nM
Cn1c(Nc2c(F)cccc2Cl)nc2cc(C(=O)Nc3cc(F)cc(C(F)(F)F)c3)c3c(c21)OCCO3 CHEMBL3897959 IC50 8.0 nM
Cn1ccnc1CNc1cc2c(cc1C(=O)N[C@H]1CC[C@H](C(F)(F)F)CC1)nc(Nc1c(Cl)ccc(CNC(=O)C(C)(C)C)c1Cl)n2C CHEMBL3665465 IC50 8.0 nM
CC(C)(O)[C@H]1CCC[C@H](NC(=O)C2CCN(c3nc4cc(Cl)c(C(F)(F)F)cc4o3)CC2)C1 CHEMBL2325076 IC50 8.3 nM
Cc1ccc(-c2ccc3c(c2)[nH]c(=O)c2nc(-c4c(F)cccc4Cl)[nH]c23)cc1 CHEMBL2387506 IC50 8.3 nM
COCc1nc2c(C(=O)NCc3ccccc3C(F)(F)F)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3965211 IC50 8.3 nM
COC(C)(C)CNc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3931869 IC50 8.3 nM
O=C(Nc1cccc(C(F)(F)F)c1)c1cc2nc(Nc3c(F)cccc3Cl)[nH]c2c2c1OCCO2 CHEMBL3935630 IC50 8.5 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(NCC(C)(C)CO)nc12 CHEMBL3916478 IC50 8.5 nM
COCc1nc2c(C(=O)Nc3ccsc3)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3941309 IC50 8.6 nM
COCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3cc(CCc4ccccc4)ccc3Cl)cc2[nH]1 CHEMBL3955869 IC50 8.7 nM
COCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3ccc(C)cc3Cl)cc2[nH]1 CHEMBL3954698 IC50 8.9 nM
CS(=O)(=O)c1ccc2c(c1)c1cc(Cl)ccc1c1nc(-c3c(C#N)cccc3C#N)[nH]c21 CHEMBL568546 IC50 9.0 nM
CC(C)NC(=O)N(Cc1ccccc1)Cc1cccc(C#Cc2cccc(C(F)(F)F)c2)c1 CHEMBL1683203 IC50 9.0 nM
Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)Nc3ccc(F)c(F)c3)c(OCC(F)F)cc21 CHEMBL3694563 IC50 9.0 nM
O=C(Nc1ccc(F)c(C(F)(F)F)c1)c1cc2nc(Nc3c(F)cccc3Cl)[nH]c2c2c1OCCO2 CHEMBL3925606 IC50 9.09 nM
O=c1[nH]c2cc(Br)ccc2c2[nH]c(-c3ccccc3Cl)nc12 CHEMBL1934810 IC50 9.1 nM
COCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3cc(F)ccc3Cl)cc2[nH]1 CHEMBL3912074 IC50 9.1 nM
Cc1ccc([N+](=O)[O-])cc1NC(=O)CSc1nnc(CNc2c(C)cccc2C)n1C CHEMBL2336516 IC50 9.3 nM
CC1(C)Oc2cc(C#Cc3cc(Cl)ccc3Cl)ccc2-c2[nH]c(-c3c(F)cccc3Cl)nc21 CHEMBL4097674 IC50 9.3 nM
CCc1nc2c(C(=O)NCc3ccccc3C(F)(F)F)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3941404 IC50 9.4 nM
Cc1cc2c(o1)c(C(=O)Nc1ccc(C(F)(F)F)cc1)cc1nc(Nc3c(Cl)cccc3Cl)[nH]c12 CHEMBL4209899 IC50 9.4 nM
O=C(Nc1cc(C(=O)NCc2ccccc2C(F)(F)F)c2nc([C@H]3CCCO3)[nH]c2c1)c1ccccc1C(F)(F)F CHEMBL4114184 IC50 9.6 nM
COc1cc(NC(=O)c2nn3c(C(F)(F)F)cc(-c4ccc(Br)cc4)nc3c2Cl)cc([N+](=O)[O-])c1 CHEMBL2336942 IC50 9.7 nM
COCCCc1ccc(Cl)c(C(=O)Nc2cc(C(=O)Nc3cccc(Cl)c3C)c3nc(COC)[nH]c3c2)c1 CHEMBL3934126 IC50 9.7 nM
COCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3cc(CCC4CC4)ccc3Cl)cc2[nH]1 CHEMBL3984488 IC50 9.7 nM
CCCN(CCO)c1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3938514 IC50 9.7 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2c(F)cccc2Cl)cc2[nH]c(NC[C@H]3CCCO3)nc12 CHEMBL4107162 IC50 9.7 nM
CCc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3ccccc3C(F)(F)F)cc2[nH]1 CHEMBL3969276 IC50 9.8 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c([C@@H]3CCCN3C)nc12 CHEMBL3923770 IC50 9.8 nM
Cc1c(Cl)cccc1NC(=O)c1cc(NC(=O)c2ccccc2C(F)(F)F)cc2[nH]c(C3CC3)nc12 CHEMBL3955576 IC50 9.8 nM
Cc1ccccc1-c1ccc2c(c1)[nH]c(=O)c1nc(-c3c(F)cccc3Cl)[nH]c12 CHEMBL2387504 IC50 9.9 nM
COC(C)(C)CNc1nc2c(C(=O)Nc3cccc(Cl)c3C)cc(NC(=O)c3cc(Cl)ccc3Cl)cc2[nH]1 CHEMBL3940919 IC50 9.9 nM