COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1 CHEMBL6 IC50 0.14 nM
Fc1ccc(-c2[nH]c(-c3ccc(F)cc3)c3c2C2CCC3C2)cc1 CHEMBL143776 IC50 1.0 nM
COc1ccc(-n2nc(OCC(F)(F)F)nc2-c2ccc(O[11CH3])cc2)cc1 CHEMBL5206077 IC50 1.0 nM
CC(C)Cc1ccc([C@H](CF)C(=O)O)cc1 CHEMBL1945285 IC50 1.23 nM
COc1ccc(-c2noc(CC(=O)O)c2-c2ccc(OC)cc2)cc1 CHEMBL259972 IC50 1.4 nM
C[C@H](C(=O)O)c1cccc(C(=O)c2ccccc2)c1 CHEMBL75435 IC50 1.9 nM
CC(C(=O)O)c1cccc(C(=O)c2ccccc2)c1 CHEMBL571 IC50 2.0 nM
CC(C)COc1c(Cl)cc2c(c1Cl)O[C@@H](C(F)(F)F)C(C(=O)O)=C2 CHEMBL1232083 IC50 2.0 nM
O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl CHEMBL139 IC50 3.0 nM
O=C([O-])Cc1ccccc1Nc1c(Cl)cccc1Cl CHEMBL1034 IC50 3.0 nM
CC(C(=O)O)c1ccc(-c2ccccc2)c(F)c1 CHEMBL563 AC50 3.0 nM
[2H]C([2H])([18F])Oc1nc(-c2ccc(OC)cc2)n(-c2ccc(OC)cc2)n1 CHEMBL5184826 IC50 4.0 nM
COc1ccc(-c2nc(OC)nn2-c2ccc(OC)cc2)cc1 CHEMBL3427203 IC50 4.9 nM
COc1ccc(C2=C(c3ccc(S(N)(=O)=O)cc3)CC3(CC3)C2)cc1 CHEMBL432945 IC50 5.0 nM
COc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(OC)cc2)cc1 CHEMBL29204 IC50 5.0 nM
COc1ccc(-c2nc(O[11CH3])nn2-c2ccc(OC)cc2)cc1 CHEMBL5192908 IC50 5.0 nM
Cc1ccc(Sc2ccccc2N2CCNCC2)c(C)c1 CHEMBL2104993 IC50 5.19 nM
CC(C(=O)O)c1ccc2c(c1)[nH]c1ccc(Cl)cc12 CHEMBL1316 IC50 5.3 nM
Nc1c(CC(=O)O)cccc1C(=O)c1ccc(Br)cc1 CHEMBL1077 AC50 6.7 nM
NS(=O)(=O)c1ccc(C2=C(c3ccc(F)cc3)c3ccccc3C2)cc1 CHEMBL80405 IC50 7.0 nM
CS(=O)(=O)c1ccc(-c2cc(Br)sc2-c2ccc(F)cc2)cc1 CHEMBL42485 IC50 7.0 nM
COc1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(Cl)cc2)cc1 CHEMBL26915 IC50 7.0 nM
Cc1ccc(Nc2c(F)cccc2Cl)c(CC(=O)O)c1 CHEMBL404108 IC50 7.0 nM
O=C(NNC(=S)Nc1ccc(Cl)c(Cl)c1)c1ccccc1O CHEMBL4476621 IC50 8.0 nM
CCc1cccc2c3c([nH]c12)C(CC)(CC(=O)O)OCC3 CHEMBL622 IC50 9.4 nM
COc1ccc(-c2nc(NCc3ccccc3)sc2-c2ccc(S(N)(=O)=O)cc2)cc1F CHEMBL16996 IC50 10.0 nM
Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(Cl)cc1 CHEMBL1241992 IC50 10.0 nM
COc1ccc2c(c1)c(CC(=O)OCC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1 CHEMBL189171 IC50 10.0 nM
COc1cc(C(=O)[N-]S(=O)(=O)c2ccc(-n3nc(C(F)(F)F)cc3-c3ccc(C)cc3)cc2)ccc1[O-] CHEMBL5273339 IC50 11.0 nM
CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 CHEMBL1401 AC50 11.4 nM
Cc1cccc(Nc2ccccc2C(=O)O)c1C CHEMBL686 AC50 11.5 nM
O=C(c1ccccc1)c1ccc2n1CCC2C(=O)O CHEMBL469 IC50 13.0 nM
COc1cc(/C=C/c2cc(/C=C/c3cc(CC=C(C)C)c(O)c(OC)c3)[nH]n2)cc(CC=C(C)C)c1O CHEMBL3290441 IC50 13.0 nM
Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 CHEMBL118 IC50 13.0 nM
Cc1ccc(-c2cc(CCC(=O)Oc3ccc(C(C)C)cc3)nn2-c2ccc3ccccc3n2)cc1 CHEMBL1830480 IC50 14.0 nM
Cc1ccc(Cl)c(Nc2ccccc2C(=O)O)c1Cl CHEMBL509 AC50 14.2 nM
O=C(O)c1nc2ccccn2c1[N+](=O)[O-] CHEMBL2235865 Kd 15.6 nM
Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1 CHEMBL865 AC50 17.1 nM
COc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(Cl)cc2)cc1 CHEMBL30011 IC50 18.0 nM
CC(C)(C)c1cc(/C=C\c2cccs2)cc2c1OCC2(C)C CHEMBL117911 IC50 20.0 nM
COc1ccc(C2NC(NCc3ccccc3)SC2c2ccc(S(N)(=O)=O)cc2)cc1F CHEMBL2037483 IC50 20.0 nM
CC1(C)Cc2c(-c3ccccc3)c(-c3occ4ccccc34)c(CC(=O)O)n2C1 CHEMBL5271431 IC50 20.0 nM
CC(=O)OC(C)OC(=O)C(C)c1ccc(-c2ccccc2)c(F)c1 CHEMBL3183067 AC50 21.2 nM
COc1cc(/C=C/C(=O)[N-]S(=O)(=O)c2ccc(-n3nc(C(F)(F)F)cc3-c3ccc(C)cc3)cc2)ccc1[O-] CHEMBL5283814 IC50 23.0 nM
Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(=O)(=O)[N-]C(=O)C(C)c3ccc(CC(C)C)cc3)cc2)cc1 CHEMBL5270291 IC50 25.0 nM
COc1ccc(-c2nc(C(=O)N3CCN(C)CC3)sc2-c2ccc(OC)cc2)cc1 CHEMBL275809 IC50 28.0 nM
Fc1ccc(-c2[nH]c(-c3ccc(F)cc3)c3c2C2CCC3CC2)cc1 CHEMBL140167 IC50 30.0 nM
CSc1ccc(-c2cn3c(c2-c2ccc(C)cc2)CCC3)cc1 CHEMBL5279593 IC50 30.0 nM
CC(C(=O)O)c1ccc(N2CC=CC2)c(Cl)c1 CHEMBL188952 AC50 32.5 nM
Cn1cccc1C(=O)c1cc(C(C)(C)C)c2c(c1)C(C)(C)CO2 CHEMBL119720 IC50 35.0 nM
CCOC(=O)[N-]S(=O)(=O)c1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(C)cc2)cc1 CHEMBL5286382 IC50 35.0 nM
COc1ccc(-n2nc(COc3cc(F)cc(C4(OC)CCOCC4)c3)cc2-c2ccccc2)cc1 CHEMBL222480 IC50 36.0 nM
Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 CHEMBL599 IC50 36.6 nM
C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1 CHEMBL553 AC50 38.8 nM
COc1ccc2c(c1)c(CC(=O)O)c(C)n2-c1ccnc2cc(Cl)ccc12 CHEMBL213029 IC50 40.0 nM
CN1C(O)=C(C(=O)Nc2ccccc2Cl)c2cc(Cl)ccc2S1(=O)=O CHEMBL173072 IC50 41.0 nM
Cc1ccc(-c2cc(CCC(=O)N3CCN(Cc4ccc(C(C)(C)C)cc4)CC3)nn2-c2ccc3ccccc3n2)cc1 CHEMBL1830471 IC50 41.0 nM
Cc1ccc(C(=O)c2ccc(CC(=O)O)n2C)cc1 CHEMBL1020 IC50 41.0 nM
COc1ccc(C(=O)c2ccccc2)cc1C(C)C(=O)O CHEMBL74276 IC50 42.0 nM
CN=[S+](C)([O-])c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1 CHEMBL1814813 IC50 42.4 nM
COc1ccc(-n2nc(CCC(=O)NCCCCNC(=O)c3ccc(C4=c5cc6c7c(c5Oc5c4cc4c8c5CCCN8CCC4)CCC[N+]=7CCC6)c(C(=O)[O-])c3)cc2-c2ccc(C)cc2)cc1 CHEMBL4792985 IC50 44.0 nM
CC(C)(C)c1cc(/C=C2\CCOC2=O)cc2c1OCC2(C)C CHEMBL2112567 IC50 45.0 nM
CC(C)(C)c1cc(C(=O)c2cccs2)cc2c1OCC2(C)C CHEMBL332937 IC50 45.0 nM
CC1(C)Cn2c(CC(=O)O)c(-c3ccc(Cl)cc3)c(-c3ccccc3)c2C1=O CHEMBL5269592 IC50 46.0 nM
COC(=O)C([11CH3])c1cccc(C(=O)c2ccccc2)c1 CHEMBL5181234 IC50 47.0 nM
CCc1onc(-c2ccccc2)c1-c1ccccc1 CHEMBL361504 IC50 50.0 nM
CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 CHEMBL56367 AC50 50.7 nM
CC(C(=O)O)c1cc(C(=O)c2ccccc2)ccc1O CHEMBL274587 IC50 51.0 nM
C/C=C/[S+]([O-])SC1SC(O)C(C)C1C CHEMBL5172589 IC50 52.0 nM
CSc1ccc(C2=C3c4ccccc4CCC3OC2=O)cc1 CHEMBL42011 IC50 53.0 nM
CC(C)(C)OC1Oc2ccccc2-c2nc(NN)ncc21 CHEMBL1938840 IC50 54.0 nM
FC(F)(F)c1cc(-c2ccc(Cl)cc2)n(-c2ccc(Cl)cc2)n1 CHEMBL284914 IC50 55.0 nM
NC(=O)N1C(=O)/C(=C(\O)c2cccs2)c2cc(Cl)ccc21 CHEMBL1908355 IC50 55.0 nM
C#CCCCC(=O)c1cc(C(C)(C)C)c2c(c1)C(C)(C)CO2 CHEMBL13920 IC50 60.0 nM
COc1ccncc1C1=C(c2ccc(S(C)(=O)=O)cc2)CCC1=O CHEMBL23241 IC50 60.0 nM
CC1(C)Oc2cc(C#Cc3cc(Cl)ccc3F)ccc2-c2[nH]c(-c3c(F)cccc3Cl)nc21 CHEMBL4067927 IC50 60.0 nM
CC1(C)Cc2c(-c3ccccc3)c(-c3ccsc3)c(CC(=O)O)n2C1 CHEMBL5280353 IC50 60.0 nM
COC1c2c(-c3ccccc3)c(-c3ccc(Cl)cc3)c(CC(=O)O)n2CC1(C)C CHEMBL5268642 IC50 60.0 nM
CSc1ccc(C2=C3c4cc(C)ccc4CCC3OC2=O)cc1 CHEMBL44142 IC50 61.0 nM
N#Cc1cnn(-c2ccc(S(N)(=O)=O)cc2)c1NC(=O)CN1CCOCC1 CHEMBL4532877 IC50 64.74 nM
NS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)c(Cl)c2-c2ccc(Cl)cc2)cc1 CHEMBL280636 IC50 65.0 nM
Cc1ccnc(C(=O)c2[nH]c3cc(Cl)c(F)cc3c2CC(=O)O)c1 CHEMBL1950016 IC50 65.9 nM
COc1ccc2cc([C@H](C)C(=O)O)ccc2c1 CHEMBL154 AC50 65.9 nM
CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1 CHEMBL2355051 AC50 66.1 nM
CCOC(=O)C1=C(N)n2c(=O)c3ncccc3c(=O)n2C1c1ccccc1O CHEMBL4071983 IC50 66.7 nM
CC1(C)CC(c2cc(C(C)(C)C)c3c(c2)C(C)(C)CO3)=NO1 CHEMBL421608 IC50 70.0 nM
Nc1cc(-c2ccco2)nn1-c1ccc(C(=O)O)cc1 CHEMBL4800072 IC50 70.0 nM
O=C(c1ccccc1O)n1nc(Nc2ccccc2)cc1-c1ccccc1O CHEMBL4065530 IC50 70.4 nM
N#Cc1cnn(-c2ccc(S(N)(=O)=O)cc2)c1NC(=O)c1ccccc1 CHEMBL4437752 IC50 73.27 nM
CCc1cc(/C=C/C(N)=O)cc(C(=O)c2ccccc2)c1 CHEMBL150130 IC50 74.0 nM
CCOC(=O)C1=C(N)n2c(=O)ccc(=O)n2C1c1ccccc1O CHEMBL4074153 IC50 74.4 nM
CC(C)(C)c1cc(-c2cn3ccsc3n2)cc2c1OCC2(C)C CHEMBL332028 IC50 75.0 nM
Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(=O)(=O)[N-]C(=O)c3ccccc3)cc2)cc1 CHEMBL5272172 IC50 76.0 nM
CSc1ccc(-c2nc3sccn3c2-c2ccccc2)cc1 CHEMBL148666 IC50 78.0 nM
NS(=O)(=O)c1ccc(-c2sc(-c3ccccc3Cl)nc2-c2ccc(F)cc2)cc1 CHEMBL17739 IC50 80.0 nM
NS(=O)(=O)c1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(F)cc2)cc1 CHEMBL29257 IC50 80.0 nM
CN1C(O)=C(C(=O)Nc2ccc(Cl)cc2Cl)c2cc(Cl)ccc2S1(=O)=O CHEMBL174777 IC50 80.0 nM
O=S(=O)(Nc1ccncc1NC1CCCCC1)C(F)(F)F CHEMBL1204023 IC50 80.0 nM
CC1=NN(C(=O)c2ccccc2O)C(=O)C1 CHEMBL4059594 IC50 82.1 nM
CCOC(=O)C1=C(N)N2C(=O)CCC(=O)N2C1c1ccccc1O CHEMBL4086962 IC50 88.1 nM
Cc1onc(-c2ccccc2)c1-c1ccccc1 CHEMBL365033 IC50 90.0 nM
COC(=O)c1ccc(-n2nc(-c3ccco3)cc2N)cc1 CHEMBL4784073 IC50 90.0 nM
O=C(NN1C(=O)c2ccccc2C1=O)c1ccccc1O CHEMBL4103357 IC50 92.2 nM
CCCC(=O)c1cc(C(C)(C)C)c2c(c1)C(C)(C)CO2 CHEMBL13980 IC50 95.0 nM
CC(C)Cc1ccc([C@H](C)C(=O)O)cc1 CHEMBL175 IC50 98.65 nM
CS(=O)(=O)c1ccc(C2=C(c3ccc(Cl)c(F)c3)C(=O)CC2)cc1 CHEMBL23175 IC50 100.0 nM
CS(=O)(=O)c1ccc(C2=C(c3cc4ccccc4s3)C(=O)CC2)cc1 CHEMBL23378 IC50 100.0 nM
COc1ccc(Nc2cnccc2NS(=O)(=O)C(F)(F)F)cc1 CHEMBL1079876 IC50 100.0 nM
N#Cc1cnn(-c2ccc(S(N)(=O)=O)cc2)c1NC(=O)CCl CHEMBL4531165 IC50 104.17 nM
COc1ccc(-c2c(Cl)ncn2-c2ccc(S(C)(=O)=O)cc2)c(F)c1 CHEMBL117528 IC50 110.0 nM
CS(=O)(=O)c1ccc(-n2cnc(Cl)c2-c2ccc3c(c2)CCO3)cc1 CHEMBL325894 IC50 110.0 nM
CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1 CHEMBL18797 IC50 115.0 nM
N#Cc1cnn(-c2ccc(S(N)(=O)=O)cc2)c1/N=C/c1ccc(Br)cc1 CHEMBL4567195 IC50 115.64 nM
CSc1ccc(/C=C2\C=C(CC(=O)O)c3cc(F)ccc32)cc1 CHEMBL496464 IC50 116.0 nM
C=C1C(c2ccccc2)=C(c2ccc(S(C)(=O)=O)cc2)C1(C)C CHEMBL92443 IC50 120.0 nM
c1ccc(-c2nn(-c3ccccc3)c3c2CCCCC3)cc1 CHEMBL348390 IC50 120.0 nM
NS(=O)(=O)c1ccc(-c2sc(COc3cc(Cl)cc(Cl)c3)nc2-c2ccc(F)cc2)cc1 CHEMBL276324 IC50 120.0 nM
CN1C(=O)/C(=C(/O)Nc2ccc(Cl)cc2)c2ccccc2C1=O CHEMBL174990 IC50 120.0 nM
CCc1ccc2c(c1)C=C(C(=O)O)C(C(F)(F)F)O2 CHEMBL1288539 IC50 120.0 nM
N#Cc1cnn(-c2ccc(S(N)(=O)=O)cc2)c1NC(=O)CCCl CHEMBL4562695 IC50 123.15 nM
Cc1c(C)c2c(c(C)c1O)CCC(C)(C(=O)O)O2 CHEMBL153 IC50 130.0 nM
CC(C)(O)COc1nc(OCCC(F)(F)F)c(CO)cc1-c1ccc(S(C)(=O)=O)cc1 CHEMBL4868446 IC50 130.0 nM
CC1(C)Cc2c(-c3ccccc3)c(-c3ccco3)c(CC(=O)O)n2C1 CHEMBL5284424 IC50 130.0 nM
CS(=O)(=O)c1ccc(C2=C(c3ccc(F)cc3)CC3(CC3)C2)cc1 CHEMBL92154 IC50 140.0 nM
NS(=O)(=O)c1ccc(C2=C(c3ccc(Cl)cc3)CC3(CC3)C2)cc1 CHEMBL88717 IC50 140.0 nM
N#Cc1nn(-c2ccc(S(N)(=O)=O)cc2)c(-c2ccc(Cl)cc2)c1Cl CHEMBL29840 IC50 140.0 nM
CN1C(O)=C(C(=O)Nc2ccc(Br)cc2Br)c2cc(Cl)ccc2S1(=O)=O CHEMBL173724 IC50 140.0 nM
O=S(=O)(Nc1ccncc1Oc1ccccc1)C(F)(F)F CHEMBL147165 IC50 140.0 nM
C=Cc1cc(Cl)cc2c1OC(C(F)(F)F)C(C(=O)O)=C2 CHEMBL1288618 IC50 140.0 nM
C#Cc1cc(Cl)c2c(c1)C=C(C(=O)O)C(C(F)(F)F)O2 CHEMBL1288640 IC50 140.0 nM
CCc1cc(C)c2c(c1)C=C(C(=O)O)C(C(F)(F)F)O2 CHEMBL1288641 IC50 140.0 nM
Cc1cc(OC(F)(F)F)cc2c1OC(C(F)(F)F)C(C(=O)O)=C2 CHEMBL1290564 IC50 140.0 nM
CC(C(=O)O)c1cccc(Oc2ccccc2)c1 CHEMBL1297 IC50 145.0 nM
CC(C)(C)c1cc(C(=O)c2ccccc2)cc2c1OCC2(C)C CHEMBL275120 IC50 150.0 nM
Cc1ccnc(C(=O)c2[nH]c3ccc(F)cc3c2CC(=O)O)c1 CHEMBL1950017 IC50 150.0 nM
CC1(C)Cc2c(-c3ccccc3)c(-c3ccc(Cl)cc3)c(CC(=O)O)n2C1 CHEMBL300982 IC50 160.0 nM
CSc1nc(-c2ccccc2)c(-c2ccc(S(C)(=O)=O)cc2)[nH]1 CHEMBL2347677 IC50 160.0 nM
CN(C)c1cc(CNCC(C)(C)C)c(O)c2c1C[C@H]1C[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C2=O CHEMBL1689772 AC50 160.0 nM
CC(C(=O)Nc1c(C#N)cnn1-c1ccc(S(N)(=O)=O)cc1)N1CCOCC1 CHEMBL4452534 IC50 161.06 nM
COc1ccc(/C=N/c2c(C#N)cnn2-c2ccc(S(N)(=O)=O)cc2)cc1OC CHEMBL4572657 IC50 162.97 nM
NS(=O)(=O)c1ccc(-c2cc(C(F)(F)F)nc(NC3CCCCC3)n2)cc1 CHEMBL561609 IC50 167.0 nM
N#Cc1cnn(-c2ccc(S(N)(=O)=O)cc2)c1/N=C/c1ccc(Cl)cc1 CHEMBL4466770 IC50 169.28 nM
NS(=O)(=O)c1ccc(-n2nc(CO)c(Cl)c2-c2ccc(Cl)cc2)cc1 CHEMBL287447 IC50 170.0 nM
CC/C(=C\c1cc(O)cc(O)c1)c1ccc2ccccc2c1 CHEMBL513053 IC50 170.0 nM
Cc1ccc(Nc2cnccc2NS(=O)(=O)C(F)(F)F)cc1 CHEMBL1080231 IC50 170.0 nM
CCSc1nc(-c2ccccc2)c(-c2ccc(S(C)(=O)=O)cc2)[nH]1 CHEMBL2347671 IC50 170.0 nM
CSc1nnc(-c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)s1 CHEMBL12532 IC50 180.0 nM
O=S(=O)(Nc1ccncc1Nc1ccccc1)C(F)(F)F CHEMBL224400 IC50 180.0 nM
COc1ccc(C2=C(c3cccc(F)c3)C(=O)OC2)cc1 CHEMBL3357103 IC50 180.0 nM
CC(C(=O)O)c1ccc(-c2cn3ccccc3n2)cc1 CHEMBL2106551 Kd 185.0 nM
O=S(=O)(Nc1ccncc1Nc1ccccc1Cl)C(F)(F)F CHEMBL1075636 IC50 190.0 nM
O=C(c1cc2cc(Cl)ccc2n1Cc1ccc(F)cc1)N1CCN(c2ccccc2)CC1 CHEMBL5184562 IC50 195.0 nM
c1ccc2c(c1)Nc1ccccc1S2 CHEMBL828 IC50 196.0 nM
COc1ccc(C2=C(c3ccc(S(N)(=O)=O)cc3)CCC2)cc1 CHEMBL111562 IC50 200.0 nM
CCc1ccc(/C=C/S(N)(=O)=O)cc1C(=O)c1ccccc1 CHEMBL147189 IC50 200.0 nM
CSc1nnc(-c2nc(C(C)(C)C)c(O)c(C(C)(C)C)n2)s1 CHEMBL275188 IC50 200.0 nM
COc1nnc(-c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)s1 CHEMBL16881 IC50 200.0 nM
CC(C)(C)c1cc(-c2cccs2)cc2c1OCC2(C)C CHEMBL118839 IC50 200.0 nM
N#Cc1cnn(-c2ccc(S(N)(=O)=O)cc2)c1/N=C/c1ccccc1 CHEMBL4450776 IC50 204.72 nM
N#Cc1ccc(-c2ccsc2-c2ccc(F)cc2)cc1 CHEMBL294050 IC50 210.0 nM
CSc1nc(-c2ccc(F)cc2)c(-c2ccc(S(C)(=O)=O)cc2)[nH]1 CHEMBL2347667 IC50 210.0 nM
Cc1cccc(/C=C/C2=NN(c3ccc(F)cc3)C(=O)CC2)c1 CHEMBL4547736 IC50 210.0 nM
CC1(C)Cc2c(-c3ccccc3)c(-c3ccc(Cl)s3)c(CC(=O)O)n2C1 CHEMBL5289423 IC50 210.0 nM
CC(C)Cc1ccc(C(C)C(=O)O)cc1 CHEMBL521 IC50 212.0 nM
CC(C)c1cc(-c2ccc(S(N)(=O)=O)cc2)c(-c2ccc(F)cc2)s1 CHEMBL417204 IC50 230.0 nM
O=C(/C=C\n1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1)NNc1cnccn1 CHEMBL3545185 AC50 230.0 nM
CN1C(O)=C(C(=O)Nc2ccc(F)cc2F)c2cc(Cl)ccc2S1(=O)=O CHEMBL177606 IC50 240.0 nM
O=S(=O)(Nc1ccncc1Oc1ccc(Br)cc1)C(F)(F)F CHEMBL374168 IC50 240.0 nM
CCSc1nc(-c2ccc(F)cc2)c(-c2ccc(S(C)(=O)=O)cc2)[nH]1 CHEMBL2347672 IC50 240.0 nM
Cc1cccc(/C=C/c2ccc(=O)n(-c3ccc(F)cc3)n2)c1 CHEMBL4574755 IC50 240.0 nM
O=C(O)C1=Cc2cc(Cl)cc(-c3ccc(Cl)cc3)c2OC1C(F)(F)F CHEMBL1669033 IC50 242.0 nM
CC(C)S(=O)(=O)c1c(O)n(Cc2ccc(F)cc2)c(=O)c2ccccc12 CHEMBL18148 IC50 250.0 nM
C#CCCCC(=O)c1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1 CHEMBL13878 IC50 250.0 nM
CC(C)(C)c1cc(/C=C2\SC(N=C(N)N)=NC2=O)cc(C(C)(C)C)c1O CHEMBL16434 IC50 250.0 nM
COc1ccc(Oc2cnccc2NS(=O)(=O)C(F)(F)F)cc1 CHEMBL225092 IC50 260.0 nM
c1ccc(Nc2ccc(Nc3ccccc3)cc2)cc1 CHEMBL1333512 IC50 260.0 nM
CC(C)=CCC1C(=O)N(c2ccccc2)N(c2ccccc2)C1=O CHEMBL1452696 AC50 260.0 nM
Nc1c(C(=O)O)nc2ccccn12 CHEMBL2235866 Kd 262.0 nM
NS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)c3c2-c2ccc(F)cc2CS3)cc1 CHEMBL316455 IC50 270.0 nM
O=S(=O)(Nc1ccncc1Oc1ccccc1Cl)C(F)(F)F CHEMBL224640 IC50 270.0 nM
CS(=O)(=O)Nc1ccncc1NC1CCCCC1 CHEMBL1204024 IC50 270.0 nM
Cc1onc(-c2ccccc2Cl)c1-c1ccccc1 CHEMBL2380863 IC50 270.0 nM
O=S(=O)(Nc1ccncc1Nc1ccc(F)cc1)C(F)(F)F CHEMBL3113240 IC50 270.0 nM
COc1ccc(-c2noc(CC(=O)OC[C@H]3O[C@@H](O)[C@H](O)[C@@H](O)[C@H]3O)c2-c2ccc(OC)cc2)cc1 CHEMBL4163044 IC50 270.0 nM
COc1ccccc1/C=C/C1=NNC(=O)CC1 CHEMBL4529760 IC50 270.0 nM
C[C@H](C(=O)O)c1ccc(C[C@H]2CCC[C@@H]2O)cc1 CHEMBL441414 IC50 280.0 nM
CC(C)(C)c1cc(C(=O)NC2CC2)cc2c1OCC2(C)C CHEMBL119170 IC50 290.0 nM
COc1ccc(/C=C/c2cc(O)cc(O)c2)cc1OC CHEMBL473518 IC50 290.0 nM
COc1ccc2c(c1)CSc1c(C(F)(F)F)nn(-c3ccc(S(N)(=O)=O)cc3)c1-2 CHEMBL319512 pIC50 299.99 nM
CNc1nnc(-c2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)s1 CHEMBL279755 IC50 300.0 nM
CC1(C)OC(=O)C(Oc2ncc(Cl)cc2Cl)=C1c1ccc(S(C)(=O)=O)cc1 CHEMBL110824 IC50 300.0 nM
CC1(C)OC(=O)C(Oc2ccc(Cl)cc2)=C1c1ccc(S(C)(=O)=O)cc1 CHEMBL325804 IC50 300.0 nM
CS(=O)(=O)c1ccc(C2=C(c3ccc(F)c(Cl)c3)C(=O)CC2)cc1 CHEMBL23808 IC50 300.0 nM
Cc1cccc(OC2=C(c3ccc(S(C)(=O)=O)cc3)C(C)(C)OC2=O)c1 CHEMBL110392 IC50 300.0 nM
Cc1ccc(-c2cc(CCC(=O)Oc3ccc(C(C)C)cc3)nn2-c2ccccc2)cc1 CHEMBL1830478 IC50 300.0 nM
O=C(O)CC1=C/C(=C\c2ccc(-c3ccccc3)cc2)c2ccc(F)cc21 CHEMBL457404 IC50 300.0 nM
NS(=O)(=O)c1ccc(C2=C(c3ccc(F)c(Cl)c3)CC3(CC3)C2)cc1 CHEMBL312822 IC50 310.0 nM
S=c1nc(-c2ccccc2)cc(-c2cn(-c3ccccc3)nc2-c2ccc(OCc3ccccc3)cc2)[nH]1 CHEMBL4443350 IC50 310.0 nM
CSc1ccc(-c2c(-c3ccccc3)nc3sccn23)cc1 CHEMBL359143 IC50 320.0 nM
COc1cc(OC(F)(F)F)cc2c1OC(C(F)(F)F)C(C(=O)O)=C2 CHEMBL1290683 IC50 320.0 nM
CSc1nc(-c2ccc(Cl)cc2)c(-c2ccc(S(C)(=O)=O)cc2)[nH]1 CHEMBL2347668 IC50 320.0 nM
Cc1ccc(-c2noc(C)c2-c2ccccc2)o1 CHEMBL2380867 IC50 320.0 nM
NS(=O)(=O)c1ccc(C2=C(c3ccc(F)cc3)CC3(CC3)C2)cc1 CHEMBL17184 IC50 330.0 nM
Cc1onc(-c2ccc(Br)o2)c1-c1ccccc1 CHEMBL2380876 IC50 330.0 nM
CC(C)S(=O)(=O)c1c(O)n(Cc2ccccc2)c(=O)c2ccccc12 CHEMBL18373 IC50 340.0 nM
CSc1ccc(-c2ccsc2-c2ccc(F)cc2)cc1 CHEMBL63286 IC50 340.0 nM
CS(=O)(=O)c1ccc(-c2[nH]c(S(C)(=O)=O)nc2-c2ccccc2)cc1 CHEMBL2347669 IC50 340.0 nM
N/N=c1\[nH][nH]/c(=N\N)c2ccccc12 CHEMBL35505 AC50 344.4 nM
CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1 CHEMBL954 IC50 346.0 nM
Cc1csc(Sc2cc3c(cc2NS(C)(=O)=O)COC3=O)n1 CHEMBL43520 IC50 350.0 nM
OCc1ccc(-c2ccsc2-c2ccc(F)cc2)cc1 CHEMBL293229 IC50 350.0 nM
CC(C)Cc1cc2c(cc1Cl)C=C(C(=O)O)[C@H](C(F)(F)F)O2 CHEMBL1630251 IC50 350.0 nM
CC(=O)Oc1ccccc1C(=O)O CHEMBL25 IC50 350.0 nM
O=S(=O)(Nc1ccncc1Oc1ccc(Cl)cc1)C(F)(F)F CHEMBL225113 IC50 360.0 nM
CCS(=O)(=O)c1nc(-c2ccccc2)c(-c2ccc(S(C)(=O)=O)cc2)[nH]1 CHEMBL2347674 IC50 360.0 nM
COc1ccc(C2=C(c3ccc(F)cc3)C(=O)OC2)cc1 CHEMBL3357104 IC50 360.0 nM
CC1(C)C(=O)C(c2ccc(F)cc2)=C1c1ccc(S(C)(=O)=O)cc1 CHEMBL91832 IC50 370.0 nM
CN1C(=O)/C(=C(/O)Nc2ccccc2)c2ccccc2C1=O CHEMBL368468 IC50 370.0 nM
Cc1ccccc1-c1c(Cl)ccc2c1C=C(C(=O)O)C(C(F)(F)F)O2 CHEMBL1630238 IC50 370.0 nM
Cc1cccc(/C=C/c2ccc(=O)[nH]n2)c1 CHEMBL4442101 IC50 370.0 nM
Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(=O)(=O)[N-]C(=O)CCCCC3CCSS3)cc2)cc1 CHEMBL5269189 IC50 370.0 nM
CC(COc1ccccc1)NN CHEMBL1909286 AC50 371.3 nM
NS(=O)(=O)c1ccc(C2=C(c3ccc(Cl)c(Cl)c3)CC3(CC3)C2)cc1 CHEMBL313387 IC50 380.0 nM
NS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)c([18F])c2-c2ccccc2)cc1 CHEMBL5208551 IC50 380.0 nM
CN1C(O)=C(C(=O)Nc2ccc(Cl)cc2)c2cc(Cl)ccc2S1(=O)=O CHEMBL369492 IC50 390.0 nM
CCSc1nc(-c2ccc(Cl)cc2)c(-c2ccc(S(C)(=O)=O)cc2)[nH]1 CHEMBL2347673 IC50 390.0 nM
CS(=O)(=O)c1ccc(-c2[nH]c(S(C)(=O)=O)nc2-c2ccc(F)cc2)cc1 CHEMBL2346675 IC50 390.0 nM
COc1ccccc1/C=C/C1=NN(c2ccccc2)C(=O)CC1 CHEMBL4564780 IC50 390.0 nM
NS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)c3c2-c2ccccc2CS3)cc1 CHEMBL329919 IC50 400.0 nM
CCCCC(=O)c1cc(C(C)(C)C)c2c(c1)C(C)(C)CCS2 CHEMBL276800 IC50 400.0 nM
COc1ccc(C2=C(c3ccc(S(N)(=O)=O)cc3)CC3(CC3)C2)cc1Br CHEMBL313313 IC50 400.0 nM
Cc1ccc2c(c1)c(-c1ccnc3cc(Cl)ccc13)c(C)n2CC(=O)O CHEMBL212777 IC50 400.0 nM
CCS(=O)(=O)c1nc(-c2ccc(F)cc2)c(-c2ccc(S(C)(=O)=O)cc2)[nH]1 CHEMBL2347675 IC50 400.0 nM
COc1ccc(-c2noc(CC(=O)NCCCCCCCCCCC(=O)OC[C@H]3OC(O)[C@H](O)[C@@H](O)[C@H]3O)c2-c2ccc(OC)cc2)cc1 CHEMBL4171339 IC50 400.0 nM
[N-]=[N+]=Nc1cc(-c2ccco2)nn1-c1ccc(C(=O)O)cc1 CHEMBL4797035 IC50 400.0 nM
O=C(NCCc1c[nH]c2ccccc12)c1cc2cc(Cl)ccc2n1Cc1ccc(F)cc1 CHEMBL5201017 IC50 406.6 nM
COC(=O)c1nn(-c2ccc(S(N)(=O)=O)cc2)c(-c2ccc(Cl)cc2)c1Cl CHEMBL28491 IC50 410.0 nM
CS(=O)(=O)Nc1ccncc1Oc1ccccc1 CHEMBL148542 IC50 410.0 nM
O=S(=O)(Nc1ccncc1Sc1ccccc1)C(F)(F)F CHEMBL224612 IC50 410.0 nM
NS(=O)(=O)c1ccc(C#Cc2cc(Cl)cc3c2OC(C(F)(F)F)C(C(=O)O)=C3)cc1 CHEMBL1290434 IC50 410.0 nM
COc1ccc(-c2cccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccccn5)ccc43)c2)cn1 CHEMBL538708 IC50 420.0 nM
CS(=O)(=O)c1ccc(-c2[nH]c(S(C)(=O)=O)nc2-c2ccc(Cl)cc2)cc1 CHEMBL2347670 IC50 420.0 nM
CC(C)(C)c1cc(-c2nsc(O)n2)cc(C(C)(C)C)c1O CHEMBL279308 IC50 430.0 nM
CCCc1cc2c(cc1Cl)C=C(C(=O)O)[C@H](C(F)(F)F)O2 CHEMBL1630249 IC50 440.0 nM
CCS(=O)(=O)c1nc(-c2ccc(Cl)cc2)c(-c2ccc(S(C)(=O)=O)cc2)[nH]1 CHEMBL2347676 IC50 440.0 nM
O=S(=O)(Nc1ccncc1Nc1cccc(F)c1)C(F)(F)F CHEMBL3113239 IC50 440.0 nM
CC(C(=O)OCCO[N+](=O)[O-])c1cccc(C(=O)c2ccccc2)c1 CHEMBL444396 IC50 450.0 nM
Cc1cccc(/C=C/C2=NNC(=O)CC2)c1 CHEMBL4435643 IC50 450.0 nM
COc1ccccc1/C=C/c1ccc(=O)n(-c2ccccc2)n1 CHEMBL4466102 IC50 460.0 nM
O=C(c1ccccc1)c1ccc2n1CC[C@@H]2C(=O)O CHEMBL496240 IC50 460.0 nM
Cc1cc(Cl)cc2c1OC(C(F)(F)F)C(C(=O)O)=C2 CHEMBL1288565 IC50 470.0 nM
CC(C(=O)O)c1ccc2c(c1)Cc1cccnc1O2 CHEMBL367463 AC50 478.0 nM
COc1ccc(C2=C(c3ccc(S(N)(=O)=O)cc3)CC3(CC3)C2)cc1F CHEMBL88532 IC50 480.0 nM
CC(C(=O)OCC(CO[N+](=O)[O-])O[N+](=O)[O-])c1ccc(C(=O)c2cccs2)cc1 CHEMBL497677 IC50 480.0 nM
CC(C)(O)[C@H](O)Cc1cc(/C=C/c2cc(O)cc(O)c2)ccc1O CHEMBL446319 IC50 480.0 nM
Cc1ccccc1Nc1cnccc1NS(=O)(=O)C(F)(F)F CHEMBL1081856 IC50 480.0 nM
CS(=O)(=O)Nc1ccncc1Nc1ccccc1Cl CHEMBL1079878 IC50 480.0 nM
O=S(=O)(O)CCS CHEMBL1098319 AC50 485.8 nM
c1ccc(-c2nn(-c3ccccc3)c3c2CCCC3)cc1 CHEMBL433892 IC50 490.0 nM
NS(=O)(=O)c1ccc(-c2oc3ccccc3c2-c2ccc(F)cc2)cc1 CHEMBL77714 IC50 490.0 nM
O=C(CC1=C/C(=C\c2ccc(-c3ccccc3)cc2)c2ccc(F)cc21)NS(=O)(=O)C(F)(F)F CHEMBL2063559 IC50 495.0 nM
CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)C23CCCC3)cc1 CHEMBL90988 IC50 500.0 nM
CC(S)CN1c2ccccc2Sc2ccccc21 CHEMBL149032 IC50 500.0 nM
NS(=O)(=O)c1ccc(C2=C(c3ccc(C(F)(F)F)cc3)CC3(CC3)C2)cc1 CHEMBL330314 IC50 500.0 nM
CS(=O)(=O)c1ccc(C2=C(c3ccc(F)cc3)C(=O)CC2)cc1 CHEMBL22812 IC50 500.0 nM
Cc1onc(-c2ccc(Cl)o2)c1-c1ccccc1 CHEMBL363228 IC50 500.0 nM
Oc1cc(O)cc(-c2cc3ccc(O)cc3o2)c1 CHEMBL512578 IC50 500.0 nM
CCc1cc(OC(F)(F)F)cc2c1OC(C(F)(F)F)C(C(=O)O)=C2 CHEMBL1290565 IC50 500.0 nM
O=C(NCCc1c[nH]c2ccc(O)cc12)c1ccccc1Nc1ccccc1 CHEMBL4789910 IC50 500.0 nM
COC1c2c(-c3ccccc3)c(-c3ccc(Cl)cc3)c(C)n2CC1(C)C CHEMBL5277274 IC50 500.0 nM
COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O[C@@H]2CCCCO2)[C@H](C)O1 CHEMBL2354444 AC50 500.0 nM
NNCCc1ccccc1 CHEMBL1089 AC50 500.1 nM
CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1 CHEMBL122 AC50 500.6 nM
CC(Cl)C(=O)Nc1c(C#N)cnn1-c1ccc(S(N)(=O)=O)cc1 CHEMBL4436821 IC50 506.8 nM
CCCCOc1nc(-c2ccc(F)cc2)c(-c2ccc(S(C)(=O)=O)cc2)cc1CO CHEMBL4867038 IC50 511.0 nM
COc1ccc(/C=N/c2c(C#N)cnn2-c2ccc(S(N)(=O)=O)cc2)cc1 CHEMBL4588711 IC50 513.0 nM
CC(C)(C)c1cc(-c2nnc(N)s2)cc(C(C)(C)C)c1O CHEMBL417073 IC50 530.0 nM
COc1ccccc1/C=C/c1ccc(=O)[nH]n1 CHEMBL4450213 IC50 530.0 nM
O=C1O[C@H]([C@@H](O)CO)C(O)=C1O CHEMBL196 AC50 533.2 nM
C=C1CC(c2ccc(S(C)(=O)=O)cc2)=C1c1ccccc1 CHEMBL91118 IC50 540.0 nM
COc1ccccc1/C=C/C1=NN(c2ccc(F)cc2)C(=O)CC1 CHEMBL4444603 IC50 540.0 nM
Cn1ccnc1S CHEMBL1515 AC50 541.1 nM
CCCNC(=O)c1cc(C(C)(C)C)c2c(c1)C(C)(C)CO2 CHEMBL122065 IC50 550.0 nM
CC(C(=O)O)c1ccc(C(=O)c2cccs2)cc1 CHEMBL956 IC50 560.0 nM
Cc1ccccc1Nc1cnccc1NS(C)(=O)=O CHEMBL1078374 IC50 560.0 nM
COc1ccc(Nc2cnccc2NS(C)(=O)=O)cc1 CHEMBL1078683 IC50 560.0 nM
CC(C)S(=O)(=O)c1c(O)n(Cc2ccc(F)c(F)c2)c(=O)c2ccccc12 CHEMBL275376 IC50 570.0 nM
Cc1ccc(-c2nc(C(F)(F)F)cn2-c2ccc(S(N)(=O)=O)cc2)cc1Cl CHEMBL298476 IC50 570.0 nM
COc1ccc(C2=C(c3ccc(S(C)(=O)=O)cc3)CC3(CC3)C2)cc1 CHEMBL89089 IC50 570.0 nM
CC(COC(=O)C(C)c1ccc(C(=O)c2cccs2)cc1)O[N+](=O)[O-] CHEMBL526643 IC50 570.0 nM
CN(C)c1ccccc1C(=O)NCCc1c[nH]c2ccc(O)cc12 CHEMBL4747587 IC50 570.0 nM
Cc1nn(-c2ccc(S(N)(=O)=O)cc2)c(-c2ccccc2)c1Cl CHEMBL283086 IC50 580.0 nM
CC(C(=O)OCCO[N+](=O)[O-])c1ccc(C(=O)c2cccs2)cc1 CHEMBL497507 IC50 580.0 nM
CC(C(=O)OCC(CO[N+](=O)[O-])O[N+](=O)[O-])c1cccc(C(=O)c2ccccc2)c1 CHEMBL497859 IC50 580.0 nM
Nc1onc(-c2ccc(Cl)o2)c1-c1ccccc1 CHEMBL3114664 IC50 580.0 nM
O=C(NCCc1c[nH]c2ccc(Cl)cc12)c1ccccc1Nc1ccccc1 CHEMBL4761676 IC50 580.0 nM
CN(C)c1ccc(-c2c(-c3ccc(S(N)(=O)=O)cc3)ccc(F)c2F)cc1Cl CHEMBL363270 -Log IC50 588.84 nM
C/C(=C1/SC(N=C(N)N)=NC1=O)c1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1 CHEMBL278246 IC50 590.0 nM
CN(C)c1ccc(-c2cc(F)c(F)cc2-c2ccc(S(N)(=O)=O)cc2)cc1Cl CHEMBL52872 IC50 590.0 nM
NS(=O)(=O)c1ccc(-n2cnc(Cl)c2-c2cc(Cl)cc(Cl)c2)cc1 CHEMBL419407 IC50 600.0 nM
Cc1nc(-c2ccc(Cl)s2)c(-c2ccc(S(N)(=O)=O)cc2)o1 CHEMBL350422 IC50 600.0 nM
CC(C)(C)c1cc(/C=C2\SC(=N)NC2=O)cc(C(C)(C)C)c1O CHEMBL275835 IC50 600.0 nM
CC(C)c1nc2sc(-c3ccc(S(C)(=O)=O)cc3)c(-c3ccccc3)n2n1 CHEMBL348115 IC50 600.0 nM
CN1C(=O)/C(=C(/O)Nc2ccc(Cl)cc2Cl)c2cc(Cl)ccc2C1=O CHEMBL177808 IC50 600.0 nM
CC(COC(=O)C(C)c1cccc(C(=O)c2ccccc2)c1)O[N+](=O)[O-] CHEMBL497858 IC50 600.0 nM
C=C(C)[C@H](CC=C(C)C)Cc1c(O)cc(OC)c(C(=O)/C=C/c2ccc(O)cc2O)c1O CHEMBL243362 IC50 600.0 nM
C=C(C)C(CC=C(C)C)Cc1c(O)cc(OC)c2c1O[C@H](c1ccc(O)cc1O)CC2=O CHEMBL243796 IC50 600.0 nM
CC(C(=O)O)c1ccc(C[C@H]2CCC[C@@H]2O)cc1F CHEMBL1275972 IC50 600.0 nM
Cc1c(CC(=O)NCCO[N+](=O)[O-])cc(-c2ccc(S(C)(=O)=O)cc2)n1-c1ccc(F)cc1 CHEMBL3104556 IC50 600.0 nM
Nc1nc(-c2ccc(Cl)cc2)cc(-c2cn(-c3ccccc3)nc2-c2ccc(OCc3ccccc3)cc2)n1 CHEMBL4545038 IC50 600.0 nM
Nc1nc2[nH]cnc2c(=S)[nH]1 CHEMBL727 IC50 601.0 nM
Cc1cccc(-c2c(-c3ccc(S(C)(=O)=O)cc3)sc3nc(C(F)(F)F)nn23)c1 CHEMBL421826 IC50 610.0 nM
CC(C)=CCc1cc(/C=C/c2cc(O)cc(O)c2)ccc1O CHEMBL457145 IC50 610.0 nM
Cc1csc(Sc2cc3c(cc2NS(C)(=O)=O)CCC3=O)n1 CHEMBL37414 IC50 620.0 nM
CS(=O)(=O)Nc1ccncc1Oc1ccc(Cl)cc1Cl CHEMBL224136 IC50 620.0 nM
CCOc1cccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccc(C)cn5)ccc43)cc2)n1 CHEMBL1922661 IC50 620.0 nM
CC[C@]1(O)C[C@@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1 CHEMBL159 AC50 623.8 nM
Oc1ccc(/C=C/c2cc(O)cc(O)c2)cc1 CHEMBL165 IC50 625.0 nM
CC(C)(C)c1cc(C(=O)CSCC2CC2)cc2c1OCC2(C)C CHEMBL417254 IC50 650.0 nM
O=C(Nc1ccc(Cl)c(Cl)c1)c1cc(Cl)cc(Cl)c1O CHEMBL291338 IC50 666.0 nM
COc1cc(/C=c2\c(=O)[nH]n3c(=O)c4ccccc4nc23)cc(OC)c1OC CHEMBL5271224 IC50 667.6 nM
N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O CHEMBL1009 AC50 670.0 nM
N#Cc1cnn(-c2ccc(S(N)(=O)=O)cc2)c1/N=C/c1ccc(F)cc1 CHEMBL4569790 IC50 676.9 nM
CCSc1nnc(-c2nc(C(C)(C)C)c(O)c(C(C)(C)C)n2)s1 CHEMBL17218 IC50 680.0 nM
COc1ccc(/C=c2\c(=O)[nH]n3c(=O)c4ccccc4nc23)cc1OC CHEMBL5274509 IC50 684.1 nM
CCc1cccc(Nc2cnccc2NS(=O)(=O)C(F)(F)F)c1 CHEMBL1080405 IC50 690.0 nM
O=C(O)C1=Cc2c(ccc(Cl)c2Cl)OC1C(F)(F)F CHEMBL1288533 IC50 690.0 nM
O=C(O)C1=Cc2cc(Cl)cc(Cl)c2O[C@@H]1C(F)(F)F CHEMBL1230348 IC50 690.0 nM
CS(=O)(=O)c1ccc(-n2nncc2-c2ccc(Cl)cc2)cc1 CHEMBL455837 IC50 700.0 nM
COc1cc(/C=C/c2ccc(O)cc2)cc(OC)c1 CHEMBL83527 IC50 700.0 nM
CCCCNc1nc(-c2ccc(S(N)(=O)=O)cc2)cc(C(F)(F)F)n1 CHEMBL538418 IC50 700.0 nM
COc1ccccc1/C=C/c1ccc(=O)n(-c2ccc(F)cc2)n1 CHEMBL4465207 IC50 700.0 nM
Cc1ccc(-c2c(-c3ccc(S(C)(=O)=O)cc3)cn3c2CCC3)cc1 CHEMBL597733 IC50 700.0 nM
CS(=O)(=O)c1ccc(C2=C(C#Cc3ccccc3)C(=O)CC2)cc1 CHEMBL278336 IC50 710.0 nM
Cc1ccc(Nc2cnccc2NS(=O)(=O)C(F)(F)F)cc1C CHEMBL3113231 IC50 710.0 nM
COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C CHEMBL1219 AC50 710.0 nM
NCCc1ccc(O)c(O)c1 CHEMBL59 AC50 726.5 nM
O=c1c2ccccc2c(S(=O)(=O)c2ccccc2)c(O)n1Cc1ccccc1 CHEMBL276052 IC50 730.0 nM
CS(=O)(=O)c1ccc(C2=C(c3ccc(F)cc3F)CC3(CC3)C2)cc1 CHEMBL314297 IC50 740.0 nM
O=C(O)C1=Cc2cc(Cl)cc(Cl)c2OC1C(F)(F)F CHEMBL1288555 IC50 740.0 nM
O=C(O)C1=Cc2cc(Cl)cc(-c3ccc(F)cc3)c2OC1C(F)(F)F CHEMBL1669032 IC50 740.0 nM
O=C(O)CCc1nc(-c2ccccc2)c(-c2ccccc2)o1 CHEMBL1071 IC50 740.0 nM
CC(=O)c1ccc(-c2ccsc2-c2ccc(F)cc2)cc1 CHEMBL66821 IC50 750.0 nM
COc1ccc2c(c1)c1c(n2C(=O)c2ccc(Cl)cc2)CCC(C(=O)O)C1 CHEMBL2323522 IC50 750.0 nM
O=C1CCC(/C=C/c2cccnc2)=NN1 CHEMBL4536976 IC50 750.0 nM
N#Cc1nn(-c2ccc(S(N)(=O)=O)cc2)c2c1SCc1cc(F)ccc1-2 CHEMBL95022 pIC50 759.98 nM
O=S(=O)(Nc1ccncc1NC1CCCCCC1)C(F)(F)F CHEMBL1079073 IC50 760.0 nM
COc1c(C(C)(C)C)cc(-c2nnc(SC)s2)cc1C(C)(C)C CHEMBL280326 IC50 770.0 nM
Cc1ccc(-c2cnnn2-c2ccc(S(C)(=O)=O)cc2)cc1 CHEMBL512917 IC50 780.0 nM
Cc1ccc(C2=C(c3ccc(F)cc3)C(=O)OC2)cc1 CHEMBL3357099 IC50 780.0 nM
CC(C)=CCC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC1=C(C)C(=O)c2ccccc2C1=O CHEMBL259223 AC50 780.1 nM
Cc1ccc2c(c1)CSc1c(C(F)(F)F)nn(-c3ccc(S(N)(=O)=O)cc3)c1-2 CHEMBL328906 pIC50 789.95 nM
Cc1c(Br)cc(-c2ccc(S(C)(=O)=O)cc2)n1-c1ccc(F)cc1 CHEMBL40245 IC50 800.0 nM
CC(C)(C)c1cc(C(=O)/C=C/CC2CC2)cc2c1OCC2(C)C CHEMBL13988 IC50 800.0 nM
Cc1ccc(-c2ncc(Cl)cc2-c2ccc(S(N)(=O)=O)cc2)cn1 CHEMBL420628 IC50 800.0 nM
Nc1ccc(NC(=O)c2ccc(C(F)(F)F)cc2)nc1 CHEMBL409023 IC50 800.0 nM
CC(C)=CCc1c(O)cc2oc3cc(O)c(O)c(CC=C(C)C)c3c(=O)c2c1O CHEMBL260553 IC50 800.0 nM
O=C(NCCc1c[nH]c2ccc(O)cc12)c1ccccc1O CHEMBL3359443 IC50 800.0 nM
CS(=O)(=O)c1ccc(-n2nncc2-c2ccccc2)cc1 CHEMBL458647 IC50 810.0 nM
FC(F)(F)c1onc(-c2ccc(Cl)o2)c1-c1ccccc1 CHEMBL2380864 IC50 810.0 nM
NS(=O)(=O)c1ccc(C2=C(c3ccc(F)cc3)CC3(CCC3)C2)cc1 CHEMBL171335 IC50 830.0 nM
COc1ccc(-c2cc(C(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 CHEMBL282085 IC50 830.0 nM
NS(=O)(=O)c1ccc(-n2nc(C(F)(F)F)c(F)c2-c2ccccc2)cc1 CHEMBL29766 IC50 830.0 nM
COc1ccc(-c2cnnn2-c2ccc(S(C)(=O)=O)cc2)cc1 CHEMBL514418 IC50 830.0 nM
O=C(/C=C/c1ccc(O)c(O)c1)OCCc1ccccc1 CHEMBL319244 IC50 833.0 nM
CC(C)(S)[C@@H](N)C(=O)O CHEMBL1430 AC50 839.3 nM
CN(C)c1ccc(-c2cnnn2-c2ccc(S(C)(=O)=O)cc2)cc1 CHEMBL457331 IC50 840.0 nM
Cc1ccnc(C(=O)c2[nH]c3cc(F)ccc3c2CC(=O)O)c1 CHEMBL1950009 IC50 849.0 nM
O=C(c1nn(Cc2ccc(F)cc2)c2ccccc12)N1CCN(c2ncccn2)CC1 CHEMBL5190868 IC50 865.5 nM
O=C1c2c(O)cccc2Cc2cccc(O)c21 CHEMBL46469 AC50 874.7 nM
N#Cc1cnn(-c2ccc(S(N)(=O)=O)cc2)c1NC(=O)CCN1CCOCC1 CHEMBL4443644 IC50 876.0 nM
CC(=O)Nc1c(C#N)cnn1-c1ccc(S(=O)(=O)NC(C)=O)cc1 CHEMBL4465079 IC50 878.8 nM
O=C(O)C1=Cc2c(cc(Cl)c(Cl)c2Cl)OC1C(F)(F)F CHEMBL1288592 IC50 880.0 nM
CCc1ccc2[nH]c(C(=O)c3cc(C)ccn3)c(CC(=O)O)c2c1 CHEMBL1950013 IC50 882.0 nM
O=C(O)Cc1ccc(-c2ccccc2)cc1 CHEMBL413965 IC50 894.0 nM
COc1ccc(-n2c(-c3ccc(S(N)(=O)=O)cc3)coc2=O)cc1 CHEMBL70478 pIC50(mM) 899.5 nM
CSc1ccc(-c2c(Cl)ncn2-c2ccc(S(C)(=O)=O)cc2)cc1 CHEMBL115410 IC50 900.0 nM
COc1ccc(-c2cscc2-c2ccc(S(C)(=O)=O)cc2)cc1 CHEMBL98903 IC50 900.0 nM
CCOC(=O)C1CCN(C(=O)CCc2cc(-c3ccc(C)cc3)n(-c3ccc4ccccc4n3)n2)CC1 CHEMBL1830479 IC50 900.0 nM
O=C(O)c1ccc(-n2nc(-c3ccco3)cc2-n2cc(CNc3ccc([N+](=O)[O-])c4nonc34)nn2)cc1 CHEMBL4758829 IC50 900.0 nM
CS(=O)(=O)c1ccc(-n2nncc2-c2ccc(F)cc2)cc1 CHEMBL457332 IC50 910.0 nM
O=S(=O)(Nc1ccncc1Nc1cccc(Br)c1)C(F)(F)F CHEMBL1079335 IC50 910.0 nM
NS(=O)(=O)c1ccc(C2=C(c3ccc(F)c(F)c3)CC3(CC3)C2)cc1 CHEMBL314225 IC50 920.0 nM
Cc1c(C(F)(F)F)nn(-c2ccc(S(N)(=O)=O)cc2)c1-c1ccc(Cl)cc1 CHEMBL29133 IC50 930.0 nM
CS(=O)(=O)Nc1ccncc1NC1CCCCCC1 CHEMBL1204025 IC50 940.0 nM
Cc1c(-c2ccc(Cl)cc2)c(-c2ccccc2)c2n1CC(C)(C)C2=O CHEMBL5277078 IC50 950.0 nM
FC(F)(F)c1cc(-c2ccccc2)n(-c2ccccc2)n1 CHEMBL28662 IC50 970.0 nM
C/C(=C\c1cc(O)cc(O)c1)c1ccc(C(F)(F)F)cc1 CHEMBL474128 IC50 970.0 nM
N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(=O)O)C(=O)O CHEMBL1543 AC50 971.4 nM
O=Cc1ccc(-c2ccsc2-c2ccc(F)cc2)cc1 CHEMBL302950 IC50 980.0 nM
CC(C)(C)c1cc(/C=C2\NC(=S)NC2=O)cc(C(C)(C)C)c1O CHEMBL15945 IC50 990.0 nM
CC/C(=C\c1ccc(C(F)(F)F)cc1)c1cc(O)cc(O)c1 CHEMBL449735 IC50 990.0 nM
Cc1cccc(Nc2cnccc2NS(=O)(=O)C(F)(F)F)c1 CHEMBL1077403 IC50 990.0 nM