CNC(=O)c1ccccc1Nc1nc(Nc2ccc(C(=O)N3CCN(C(=S)SCCN(C)C)CC3)cc2)ncc1C(F)(F)F CHEMBL4554455 IC50 0.07 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(CN3CCSCC3)cc2)ncc1Cl CHEMBL5170906 IC50 0.1 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(NC(=O)CN3CCC(C(=O)NCCCCCC(=O)NO)CC3)cc2)ncc1Cl CHEMBL5198068 IC50 0.1076 nM
CCOP(=O)(CC(=O)Nc1ccc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)cc1)OCC CHEMBL5196177 IC50 0.1165 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(CN3CCC(C(=O)NCCCCCC(=O)NO)CC3)cc2)ncc1Cl CHEMBL5176233 IC50 0.1242 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCC(C(=O)NCCCCCC(=O)NO)CC3)cc2)ncc1Cl CHEMBL5206909 IC50 0.1534 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(NC(=O)CN3CCC(C(=O)O)CC3)cc2)ncc1Cl CHEMBL5187385 IC50 0.161 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(CN3CCC(C(=O)NCCO)CC3)cc2)ncc1Cl CHEMBL5190968 IC50 0.1924 nM
CCC(C)C(CO)NC(=O)C1CCN(Cc2ccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)cc2)CC1 CHEMBL5177776 IC50 0.1941 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3nccnc3N(C)S(C)(=O)=O)n2)cc1 CHEMBL3137331 IC50 0.2 nM
COc1cc(C2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(CCc2ccccc2CC(N)=O)n1 CHEMBL3689071 Kd 0.21 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(CN3CCC(CO)CC3)cc2)ncc1Cl CHEMBL5176990 IC50 0.2131 nM
C=CC(=O)NCCNc1c(NCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC)n3)cc2)c(=O)c1=O CHEMBL4752642 Ki 0.23 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(OCC(=O)N3CCOCC3)cc2)ncc1Cl CHEMBL5204729 IC50 0.275 nM
COc1cc(N2CCNCC2)ccc1Nc1ncc(C(F)(F)F)c(CCc2ccccc2CC(N)=O)n1 CHEMBL3689069 Kd 0.29 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(CN3CCC(C(=O)O)CC3)cc2)ncc1Cl CHEMBL5186801 IC50 0.2963 nM
CN1CCc2cc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)ccc2C1 CHEMBL3692193 IC50 0.3 nM
CCOP(=O)(Cc1ccc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)cc1)OCC CHEMBL5178369 IC50 0.3146 nM
COC(=O)CCCCCNC(=O)C1CCN(CC(=O)Nc2ccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)cc2)CC1 CHEMBL5199835 IC50 0.3146 nM
CC(=O)N1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)cc2)CC1 CHEMBL3692188 IC50 0.39 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(CNc3c(NCCNC(=O)/C(C#N)=C/C4CC4)c(=O)c3=O)cc2)ncc1Cl CHEMBL4750273 Ki 0.4 nM
CONC(=O)c1ccccc1Nc1cc(Nc2cc(C)nn2C(C)C)ncc1Cl CHEMBL4742157 IC50 0.4 nM
NC(=O)Cc1ccccc1CCc1nc(Nc2ccc3c(c2)CCNC3)ncc1C(F)(F)F CHEMBL3692186 Kd 0.44 nM
CC(=O)N1CCN(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)cc2)CC1 CHEMBL3639910 Kd 0.47 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(CNc3c(NCCNC(=O)/C(C#N)=C/C(C)C)c(=O)c3=O)cc2)ncc1Cl CHEMBL4783568 Ki 0.47 nM
CN1CCN(Cc2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)cc2)CC1 CHEMBL3692201 Kd 0.48 nM
NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(N3CCNCC3)cc2)ncc1C(F)(F)F CHEMBL3692169 Kd 0.49 nM
CN(c1ccccc1CNc1nc(Nc2ccc3c(c2)CNC3=O)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL487229 IC50 0.5 nM
C=CCN(c1ncccc1CNc1nc(Nc2ccc(N3CCOCC3)c(Br)c2)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL3965256 IC50 0.51 nM
C=CCN(c1ncccc1CNc1nc(Nc2cccc(Br)c2)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL3892377 IC50 0.51 nM
COCC1CN(C2CCN(c3cc(OC)c(Nc4ncc(Br)c(Nc5ccc6c(c5P(C)(C)=O)OCCO6)n4)cc3C)CC2)C1 CHEMBL5188373 IC50 0.51 nM
COC(=O)CCCCCNC(=O)C1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)cc2)CC1 CHEMBL5177168 IC50 0.5143 nM
CN1CCCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)cc2)C1 CHEMBL3692173 Kd 0.57 nM
CCOC(=O)C1CCN(Cc2ccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)cc2)CC1 CHEMBL5192604 IC50 0.5794 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3cccnc3N(C)S(C)(=O)=O)n2)cc1 CHEMBL4862042 IC50 0.6 nM
NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(C3CCNCC3)cc2)ncc1C(F)(F)F CHEMBL3692178 Kd 0.61 nM
NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(N3CCC(N)CC3)cc2)ncc1C(F)(F)F CHEMBL3692185 Kd 0.63 nM
CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL1084546 pKi 0.631 nM
NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(C3CCCNC3)cc2)ncc1C(F)(F)F CHEMBL3692172 Kd 0.73 nM
COc1cc(C2CCNCC2)ccc1Nc1ncc(C(F)(F)F)c(CCc2ccccc2CC(N)=O)n1 CHEMBL3689070 Kd 0.74 nM
CC(=O)C1CCN(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)cc2)CC1 CHEMBL3692189 IC50 0.77 nM
NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(C3CCNCC3)cc2OC(F)(F)F)ncc1C(F)(F)F CHEMBL3689078 Kd 0.79 nM
CCc1cc(C2CCNCC2)ccc1Nc1ncc(C(F)(F)F)c(CCc2ccccc2CC(N)=O)n1 CHEMBL3689076 Kd 0.81 nM
CN1CCN(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)cc2)CC1 CHEMBL3692171 Kd 0.91 nM
CC(C(N)=O)c1ccccc1CCc1nc(Nc2ccc(C3CCNCC3)cc2)ncc1C(F)(F)F CHEMBL3692179 Kd 0.92 nM
CN(c1ccccc1CNc1nc(Nc2ccc(S(C)(=O)=O)cc2)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL488247 IC50 0.94 nM
CCN1CCN(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)cc2)CC1 CHEMBL3692177 Kd 0.96 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCC(C(=O)O)CC3)cc2)ncc1Cl CHEMBL5180558 IC50 0.9763 nM
NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(C3CNCCO3)cc2)ncc1C(F)(F)F CHEMBL3692187 Kd 0.99 nM
CN(c1ccccc1CNc1nc(Nc2ccc3c(c2)CS(=O)(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL452341 IC50 1.0 nM
CN(c1ccccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL472212 IC50 1.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2OC)CCC[C@@H](N2CCN(CCO)CC2)C3)ncc1Cl CHEMBL3972653 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657281 IC50 1.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C[C@H]2F)c(Cl)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)C(C)C3C)n1 CHEMBL3657246 IC50 1.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C[C@H]2F)c(Cl)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)[C@H]3C)n1 CHEMBL3657289 IC50 1.0 nM
COc1cc(C(=O)N[C@@H]2CCN(C)C[C@@H]2F)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657306 IC50 1.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C[C@H]2F)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657307 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(Cl)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657310 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657311 IC50 1.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C[C@H]2F)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657312 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657320 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(OC)C3)n1 CHEMBL3657323 IC50 1.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C[C@H]2F)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3C)n1 CHEMBL3657330 IC50 1.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)C3C)n1 CHEMBL3657331 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(Cl)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657332 IC50 1.0 nM
COc1cc(CN(C)C)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657333 IC50 1.0 nM
COc1cc(CN2CCCC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657334 IC50 1.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657341 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3C)n1 CHEMBL3657344 IC50 1.0 nM
COc1cc(O[C@@H]2CO[C@H]3[C@@H]2OC[C@H]3O)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3C)n1 CHEMBL3657345 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(Cl)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3C)n1 CHEMBL3657351 IC50 1.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc(C#N)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657352 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(Cl)cc1Nc1ncc(C#N)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657354 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(OC)C3)n1 CHEMBL3657355 IC50 1.0 nM
COc1cc(C(=O)N[C@@H]2CCCN(C)C2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(OC)C3)n1 CHEMBL3657356 IC50 1.0 nM
COc1cc(C(=O)N[C@@H]2CCCN(C)C2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(OC)C3)n1 CHEMBL3657357 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3(C)C)n1 CHEMBL3657358 IC50 1.0 nM
COc1cc(C(=O)N[C@@H]2CCN(C)C[C@@H]2OC)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657359 IC50 1.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C[C@H]2F)c(Cl)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3(C)C)n1 CHEMBL3657360 IC50 1.0 nM
COc1cc(C(=O)N[C@@H]2CCN(C)C[C@@H]2OC)c(Cl)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3(C)C)n1 CHEMBL3657361 IC50 1.0 nM
COc1cc(C(=O)NCCN(C)C)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657365 IC50 1.0 nM
COc1cc(C(=O)NC[C@H](O)CO)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657368 IC50 1.0 nM
COc1cc(C(=O)N[C@H]2CCCN(C)C2)c(Cl)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657370 IC50 1.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C[C@H]2F)c(Cl)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657371 IC50 1.0 nM
COc1cc(C(=O)N[C@@H]2CCN(C)C[C@@H]2OC)c(Cl)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657372 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C3CCOCC3)CC2)c(Cl)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657373 IC50 1.0 nM
COc1cc(C(=O)NC2CCCN(C)C2)c(C)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657376 IC50 1.0 nM
COc1cc(C(=O)N[C@@H]2CCCN(C)C2)c(C)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657377 IC50 1.0 nM
COc1cc(C(=O)N[C@H]2CCCN(C)C2)c(C)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657378 IC50 1.0 nM
COc1cc(C(=O)NCCN(C)C)c(C)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657379 IC50 1.0 nM
CNC(=O)c1cc(OC)c(Nc2ncc(C(F)(F)F)c(Oc3cccc4c3C(=O)N(C)C4)n2)cc1C CHEMBL3657381 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(C)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657382 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(C)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657383 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(Cl)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)[C@H]3C)n1 CHEMBL3657385 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(Cl)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)[C@@H]3C)n1 CHEMBL3657386 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)[C@H]3C)n1 CHEMBL3657387 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)[C@@H]3C)n1 CHEMBL3657388 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C3CCOCC3)CC2)c(C)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657389 IC50 1.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C[C@H]2OC)c(Cl)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)[C@H]3C)n1 CHEMBL3657392 IC50 1.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C[C@H]2F)c(F)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(OC)C3)n1 CHEMBL3657396 IC50 1.0 nM
COc1cc(C(=O)N[C@@H]2CCN(C)C[C@@H]2OC)c(F)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(OC)C3)n1 CHEMBL3657397 IC50 1.0 nM
COc1cc(C(=O)N[C@@H]2CCN(C)C[C@@H]2OC)c(Cl)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)[C@@H]3C)n1 CHEMBL3657398 IC50 1.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C[C@H]2F)c(Cl)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)[C@@H]3C)n1 CHEMBL3657399 IC50 1.0 nM
COc1cc(C(=O)N[C@@H]2CCN(C)C[C@@H]2OC)c(F)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)[C@H]3C)n1 CHEMBL3657400 IC50 1.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C[C@H]2F)c(F)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)[C@@H]3C)n1 CHEMBL3657401 IC50 1.0 nM
COc1cc(C(=O)N[C@@H]2CCN(C)C[C@@H]2OC)c(F)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)[C@@H]3C)n1 CHEMBL3657402 IC50 1.0 nM
CCN1CC[C@H](NC(=O)c2cc(OC)c(Nc3ncc(Cl)c(Oc4cccc5c4C(=O)N(C)[C@H]5C)n3)cc2F)[C@H](F)C1 CHEMBL3657403 IC50 1.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C[C@H]2F)c(F)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)[C@H]3C)n1 CHEMBL3657405 IC50 1.0 nM
COc1cc(C(=O)N[C@@H]2CCN(C)C[C@@H]2OC)c(F)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657407 IC50 1.0 nM
COc1cc(C(=O)N[C@@H]2CCN(C)C[C@@H]2OC)c(C)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657408 IC50 1.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C[C@H]2F)c(C)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657409 IC50 1.0 nM
COc1cc(C(=O)N[C@@H]2CCN(C)C[C@@H]2OC)c(C)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)C3(C)C)n1 CHEMBL3657411 IC50 1.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C[C@H]2F)c(C)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)C3(C)C)n1 CHEMBL3657412 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(CCO)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661424 IC50 1.0 nM
CONC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Oc3cccc4c3C(=O)N(C)C4)n2)c(OC)c1 CHEMBL3661425 IC50 1.0 nM
Cc1cc(C(=O)NC2CCN(CCO)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661428 IC50 1.0 nM
COCCN1CCC(NC(=O)c2ccc(Nc3ncc(C(F)(F)F)c(Oc4cccc5c4C(=O)N(C)C5)n3)c(C)c2)CC1 CHEMBL3661430 IC50 1.0 nM
COCCN1CCC(NC(=O)c2ccc(Nc3ncc(C(F)(F)F)c(Oc4cccc5c4C(=O)N(C)C5)n3)c(OC)c2)CC1 CHEMBL3661435 IC50 1.0 nM
Cc1cc(C(=O)NC2CCCN(C)C2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661436 IC50 1.0 nM
Cc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661437 IC50 1.0 nM
COCCNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Oc3cccc4c3C(=O)N(C)C4)n2)c(OC)c1 CHEMBL3661439 IC50 1.0 nM
COc1cc(C[C@@H](O)CO)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661442 IC50 1.0 nM
COc1cc(C[C@H](O)CO)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661443 IC50 1.0 nM
COc1cc(N2CCN(C(C)C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661444 IC50 1.0 nM
COc1cc(N2CCN(CC(=O)N(C)C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661445 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C)C[C@H]2OC)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661451 IC50 1.0 nM
COc1cc(C(=O)NC2CCN(C)C[C@H]2OC)c(C)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)C3(C)C)n1 CHEMBL3661452 IC50 1.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C[C@@H]2OC)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661453 IC50 1.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C[C@@H]2OC)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661454 IC50 1.0 nM
COc1cc(C#CCN(C)C)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661455 IC50 1.0 nM
COc1cc(C(=O)N[C@@H]2CCN(C)C[C@H]2OC)c(C)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661456 IC50 1.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C[C@@H]2OC)c(C)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661457 IC50 1.0 nM
NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(C3CCCCN3)cc2)ncc1C(F)(F)F CHEMBL3692175 Kd 1.0 nM
CCN1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)cc2)CC1 CHEMBL3692196 Kd 1.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 1.1 nM
NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(CN3CCNCC3)cc2)ncc1C(F)(F)F CHEMBL3692190 Kd 1.1 nM
CS(=O)(=O)N1CCCc2cccc(c2)Nc2ncc(C(F)(F)F)c(n2)NCc2cccnc21 CHEMBL3949755 IC50 1.26 nM
CN1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)cc2)CC1 CHEMBL3692181 Kd 1.3 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(SCCCN3CCOCC3)cc2)ncc1Cl CHEMBL5195974 IC50 1.336 nM
CCOC(=O)C1CCN(CC(=O)Nc2ccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)cc2)CC1 CHEMBL5197230 IC50 1.415 nM
CNC(=O)c1ccccc1Nc1cc(Nc2ccc(N3CCOCC3)cc2OC)ncc1C(F)(F)F CHEMBL2430358 IC50 1.5 nM
CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL2430359 IC50 1.5 nM
CN1CCN(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4cccc(C(N)=O)c4)n3)cc2)CC1 CHEMBL3692170 Kd 1.5 nM
CCN1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)c(OC)c2)CC1 CHEMBL3689072 Kd 1.5 nM
CCc1cc(C2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(CCc2ccccc2CC(N)=O)n1 CHEMBL3689077 Kd 1.5 nM
CNC(=O)c1ccccc1Nc1cc(Nc2ccc(N3CCOCC3)cc2OC)ncc1C(F)(F)F CHEMBL3040440 IC50 1.5 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1C(F)(F)F CHEMBL5398556 IC50 1.5 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl CHEMBL458997 pKi 1.585 nM
NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(C3CCNC3)cc2)ncc1C(F)(F)F CHEMBL3692200 Kd 1.6 nM
CN1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)c(OC(F)(F)F)c2)CC1 CHEMBL3689079 Kd 1.7 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccccc3OC)n2)cc1 CHEMBL4874046 IC50 1.87 nM
COc1cc(C(=O)NC2CCNCC2)ccc1Nc1nc(Oc2cccc3c2C(=O)CC3)c2cc[nH]c2n1 CHEMBL5202126 IC50 1.89 nM
CN(c1cccc(CNc2nc(Nc3ccc4c(c3)CC(=O)N4)ncc2C(F)(F)F)c1)S(C)(=O)=O CHEMBL513744 IC50 1.9 nM
NC(COc1cncc(-c2ccc3cnccc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL1981133 pKi 1.995 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2OC)CCC[C@H](N2CCN(CCO)CC2)C3)ncc1Cl CHEMBL3951811 IC50 2.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C[C@H]2F)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657249 IC50 2.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657265 IC50 2.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(CCF)[C@H]3C)n1 CHEMBL3657277 IC50 2.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(CCF)[C@@H]3C)n1 CHEMBL3657278 IC50 2.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(OC)C3)n1 CHEMBL3657282 IC50 2.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2ccc(C)c3c2C(=O)CC3)n1 CHEMBL3657283 IC50 2.0 nM
CCN1CCC(NC(=O)c2cc(OC)c(Nc3ncc(C(F)(F)F)c(Oc4cccc5c4C(=O)N(C)C5)n3)cc2Cl)CC1 CHEMBL3657302 IC50 2.0 nM
CCN1CCC(NC(=O)c2ccc(Nc3ncc(C(F)(F)F)c(Oc4cccc5c4C(=O)N(C)C5)n3)c(OC)c2)CC1 CHEMBL3657303 IC50 2.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C[C@H]2F)c(Cl)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657304 IC50 2.0 nM
COc1cc(C(=O)N[C@@H]2CCN(C)C[C@@H]2F)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657308 IC50 2.0 nM
CCN1CCC(NC(=O)c2cc(OC)c(Nc3ncc(C(F)(F)F)c(Oc4cccc5c4C(=O)N(C)C5)n3)cc2F)CC1 CHEMBL3657309 IC50 2.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)CC3)n1 CHEMBL3657318 IC50 2.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(Br)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657319 IC50 2.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657325 IC50 2.0 nM
CN1CCC(Nc2ccc(Nc3ncc(C(F)(F)F)c(Oc4cccc5c4C(=O)N(C)C5)n3)cc2F)CC1 CHEMBL3657342 IC50 2.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657348 IC50 2.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(C#N)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657353 IC50 2.0 nM
COc1cc(C(=O)NCC(C)(C)CN(C)C)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657362 IC50 2.0 nM
COc1cc(C(=O)N[C@H]2CC[C@H](O)CC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657366 IC50 2.0 nM
COc1cc(C(=O)NC2CCN(C3CC3)CC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657367 IC50 2.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657369 IC50 2.0 nM
COc1cc(N2CCN(CC3CC3)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657374 IC50 2.0 nM
COc1cc(C(=O)N[C@H]2CC[C@H](N3CCN(CC4CC4)CC3)CC2)c(C)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657390 IC50 2.0 nM
COc1cc(C(=O)NCC2CC2)c(C)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657391 IC50 2.0 nM
COc1cc(C(=O)NC2CCN(C3CCOCC3)CC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657395 IC50 2.0 nM
COc1cc(C(=O)N[C@H]2CCN(C(C)C)C[C@H]2F)c(F)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)[C@H]3C)n1 CHEMBL3657404 IC50 2.0 nM
COc1cc(C(=O)N[C@@H]2CCN(C)C[C@@H]2F)c(F)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657406 IC50 2.0 nM
COCCNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Oc3cccc4c3C(=O)N(C)C4)n2)c(C)c1 CHEMBL3661427 IC50 2.0 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Oc3cccc4c3C(=O)N(C)C4)n2)c(C)c1 CHEMBL3661431 IC50 2.0 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Oc3cccc4c3C(=O)N(C)C4)n2)c(OC)c1 CHEMBL3661432 IC50 2.0 nM
COc1cc(CN(C)C)ccc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661441 IC50 2.0 nM
COc1cc(N2CCN(CC(=O)N(C)OC)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661446 IC50 2.0 nM
COc1cc(N2CCN(C3COC3)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661447 IC50 2.0 nM
COc1cc(C(=O)NC2CCN(C)C[C@H]2OC)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661448 IC50 2.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2ccc(C)c3c2C(=O)N(C)C3)n1 CHEMBL3661450 IC50 2.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1nc(Oc2ccc(C)c3c2C(=O)CC3)c2cc[nH]c2n1 CHEMBL5181891 IC50 2.04 nM
COc1cc(C2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(CCc2cccc(C(N)=O)c2)n1 CHEMBL3689074 IC50 2.1 nM
COc1c(Nc2ncc(Cl)c(Nc3ccccc3N(C)S(C)(=O)=O)n2)ccc2c1CCCC(N1CCN(C)CC1)C2 CHEMBL3961771 IC50 2.2 nM
COc1c(Nc2ncc(Cl)c(Nc3ccccc3N(C)S(C)(=O)=O)n2)ccc2c1CCCC(N1CCN(CCO)CC1)C2 CHEMBL3934268 IC50 2.4 nM
Cc1ccc(Oc2nc(Nc3ccc(N4CCC(N5CCN(C)CC5)CC4)cc3)nc3[nH]ccc23)c2c1CCC2=O CHEMBL5209255 IC50 2.47 nM
NC(=O)Cc1cccnc1CCc1nc(Nc2ccc(C3CCNCC3)cc2)ncc1C(F)(F)F CHEMBL3692197 Kd 2.5 nM
CN1CCCCC1c1ccc(Nc2ncc(C(F)(F)F)c(CCc3ccccc3CC(N)=O)n2)cc1 CHEMBL3692176 IC50 2.5 nM
CC/C=C(\C#N)C(=O)NCCNc1c(NCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC)n3)cc2)c(=O)c1=O CHEMBL4796523 IC50 2.5 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 2.512 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(SCC(=O)N3CCOCC3)cc2)ncc1Cl CHEMBL4471571 IC50 2.58 nM
C=CC(=O)NCCNc1c(NCc2ccc(Nc3ncc(C(F)(F)F)c(Nc4ccccc4C(=O)NC)n3)cc2)c(=O)c1=O CHEMBL4777260 Ki 2.64 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3ccccc3Cl)n2)cc1 CHEMBL4850588 IC50 2.75 nM
CN1CCN(C2CCN(c3ccc(Nc4nc(Oc5cccc6c5C(=O)CC6)c5cc[nH]c5n4)cc3)CC2)CC1 CHEMBL5200984 IC50 2.91 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2ccccc2NS(C)(=O)=O)n1 CHEMBL3665934 IC50 3.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)OC3)n1 CHEMBL3657247 IC50 3.0 nM
COc1cc(C(=O)N[C@@H]2CCN(C)C[C@@H]2F)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657250 IC50 3.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C[C@@H]2F)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657252 IC50 3.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(Cl)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657259 IC50 3.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(CCF)C3C)n1 CHEMBL3657273 IC50 3.0 nM
COc1cc(C(=O)NC2CCOCC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)OC3)n1 CHEMBL3657274 IC50 3.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2ccc(C)c3c2C(=O)CC3)n1 CHEMBL3657284 IC50 3.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(C)C)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657324 IC50 3.0 nM
COc1cc(O[C@@H]2CO[C@H]3[C@@H]2OC[C@H]3O)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3639561 IC50 3.0 nM
COc1cc(C(=O)NC2CCOC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657363 IC50 3.0 nM
COc1cc(C(=O)N(C)C)c(C)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657380 IC50 3.0 nM
COc1cc(C(=O)NC2CCOCC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657384 IC50 3.0 nM
COc1cc(C(=O)N[C@H]2CC[C@H](N3CCN(CC4CC4)CC3)CC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657394 IC50 3.0 nM
CC(=O)N1CCC(NC(=O)c2ccc(Nc3ncc(C(F)(F)F)c(Oc4cccc5c4C(=O)N(C)C5)n3)c(C)c2)CC1 CHEMBL3661426 IC50 3.0 nM
CONC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Oc3cccc4c3C(=O)N(C)C4)n2)c(C)c1 CHEMBL3661438 IC50 3.0 nM
COCCCNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Oc3cccc4c3C(=O)N(C)C4)n2)c(OC)c1 CHEMBL3661440 IC50 3.0 nM
COc1cc(/C(C)=C/C(=O)N(C)C)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661459 IC50 3.0 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOc2ccc(Nc3ncc(C(F)(F)F)c(NCc4cccc(N(C)S(C)(=O)=O)c4)n3)cc2)C(C)(C)C)cc1 CHEMBL4447794 EC50 3.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2OC)CCCC(N2CCN(CCO)CC2)C3)ncc1Cl CHEMBL3890564 IC50 3.1 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 3.162 nM
CS(=O)(=O)N1CCCCC(=O)N2CCc3cc(ccc32)Nc2ncc(C(F)(F)F)c(n2)NCc2ccccc21 CHEMBL3956954 IC50 3.2 nM
CS(=O)(=O)N1CCCc2cc(ccc2N2CCOCC2)Nc2ncc(C(F)(F)F)c(n2)NCc2cccnc21 CHEMBL3987106 IC50 3.21 nM
CCS(=O)(=O)N(CCCCC(=O)O)c1ccccc1CNc1nc(Nc2ccc3c(c2)CCN3)ncc1C(F)(F)F CHEMBL3936048 IC50 3.3 nM
CN1CCN(c2cccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)c2)CC1 CHEMBL3692182 IC50 3.4 nM
Cc1cc(C2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(CCc2ccccc2CC(N)=O)n1 CHEMBL3689080 IC50 3.6 nM
C=CC(=O)NCCNc1c(NCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NOC)n3)cc2)c(=O)c1=O CHEMBL4788979 IC50 3.7 nM
COc1c(Nc2ncc(Cl)c(Nc3ccccc3N3CCCS3(=O)=O)n2)ccc2c1CCCC(N1CCN(CCO)CC1)C2 CHEMBL3925372 IC50 3.8 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1nc(Oc2cccc3c2C(=O)CC3)c2cc[nH]c2n1 CHEMBL5198291 IC50 3.86 nM
Cc1cc(Nc2nc(Oc3cccc4c3C(=O)CC4)c3cc[nH]c3n2)ccc1OCCN(C)C CHEMBL5169896 IC50 3.93 nM
COc1cc(Nc2ncc3ccn(-c4cccc(CCC(=O)O)n4)c3n2)cc(OC)c1OC CHEMBL207491 IC50 4.0 nM
CS(=O)(=O)c1cccc(CNc2nc(Nc3ccc4c(c3)CCC(=O)N4)ncc2C(F)(F)F)c1 CHEMBL514554 IC50 4.0 nM
COc1c(Nc2ncc(Cl)c(Nc3ccccc3-c3nccn3C)n2)ccc2c1CCCC(N1CCN(CCO)CC1)C2 CHEMBL3961598 IC50 4.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cc(F)ccc2NS(C)(=O)=O)n1 CHEMBL3665942 IC50 4.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)OC3)n1 CHEMBL3657248 IC50 4.0 nM
COc1cc(C(=O)N[C@@H]2CCN(C)C[C@@H]2F)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657253 IC50 4.0 nM
COc1cc(C(=O)N[C@@H]2CCN(C)C2)c(Cl)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657260 IC50 4.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657268 IC50 4.0 nM
O=C1Cc2cc(Nc3ncc(C(F)(F)F)c(Oc4cccc5c4C(=O)OC5)n3)ccc2N1 CHEMBL3657275 IC50 4.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(CCF)[C@H]3C)n1 CHEMBL3657279 IC50 4.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(CCF)[C@@H]3C)n1 CHEMBL3657280 IC50 4.0 nM
COc1cc(C(=O)N[C@@H]2CCN(C)C[C@@H]2F)c(Cl)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657305 IC50 4.0 nM
COc1cc(O[C@H]2CCOC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657337 IC50 4.0 nM
COc1cc(C(=O)NC2CCN(C3CCOCC3)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657245 IC50 4.0 nM
COc1cc(C(=O)NC2CCOCC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(OC)C3)n1 CHEMBL3657410 IC50 4.0 nM
COc1cc(C#CC(=O)N(C)C)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661449 IC50 4.0 nM
COc1cc(/C=C/C(=O)N(C)C)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661458 IC50 4.0 nM
CS(=O)(=O)c1cccc(CNc2nc(Nc3ccc4c(c3)CC(=O)N4)ncc2C(F)(F)F)c1 CHEMBL487246 IC50 4.0 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3cccc(Br)c3)n2)cc1 CHEMBL4872224 IC50 4.02 nM
COc1ccc(Cn2ncc(NC(=O)c3cc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)ccc3C)c2N)cc1 CHEMBL1684800 IC50 4.13 nM
CN1CCN(c2cccc(Nc3ncc(C(F)(F)F)c(CCc4cccc(C(N)=O)c4)n3)c2)CC1 CHEMBL3692174 IC50 4.2 nM
Cc1cc(Nc2nc(Oc3cccc4c3C(=O)CC4)c3cc[nH]c3n2)ccc1N1CCN(CC2CC2)CC1 CHEMBL5185675 IC50 4.2 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3cccc(F)c3)n2)cc1 CHEMBL4873348 IC50 4.24 nM
CCOP(=O)(Cc1ccc(Nc2ncc(Cl)c(Nc3ccccc3C(=O)NC)n2)cc1)OCC CHEMBL4218201 IC50 4.25 nM
CS(=O)(=O)N1C/C=C/c2cc(ccc2N2CCOCC2)Nc2ncc(C(F)(F)F)c(n2)NCc2cccnc21 CHEMBL3958414 IC50 4.34 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3ccc(F)cc3)n2)cc1 CHEMBL4860092 IC50 4.44 nM
C=CC(=O)NCCNc1c(NCc2ccc(Nc3ncc(Cl)c(NCc4ccccc4N(C)S(C)(=O)=O)n3)cc2)c(=O)c1=O CHEMBL4746264 IC50 4.6 nM
CCOP(=O)(CCCOc1ccc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(=O)NC)n2)cc1)N1CCOCC1 CHEMBL4216755 IC50 4.65 nM
CN(c1cccc(CNc2nc(Nc3ccc(OCCOCCOCCC(=O)NCCOc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc3)ncc2C(F)(F)F)c1)S(C)(=O)=O CHEMBL4586249 IC50 4.7 nM
CN1CCN(c2ccc(Nc3nc(Oc4cccc5c4C(=O)CC5)c4cc[nH]c4n3)cc2Cl)CC1 CHEMBL5184675 IC50 4.8 nM
C=CC(=O)NCCNc1c(NCc2ccc(Nc3ncc(Cl)c(NCc4cccc(N(C)S(C)(=O)=O)c4)n3)cc2)c(=O)c1=O CHEMBL4739917 IC50 4.9 nM
CN(c1ccccc1-c1cc(Cl)c2cnc(Nc3ccc(C4CCN(CC(N)=O)CC4)cc3)nn12)S(C)(=O)=O CHEMBL1934353 IC50 5.0 nM
COc1cc(C(=O)N[C@@H]2CCN(C)C[C@H]2F)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657251 IC50 5.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C[C@H]2F)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657254 IC50 5.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C2)c(Cl)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657261 IC50 5.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(Cl)cc1Nc1ncc(C(F)(F)F)c(Oc2ccc(C)c3c2C(=O)CC3)n1 CHEMBL3657262 IC50 5.0 nM
COc1cc(C(=O)NC2CCC(O)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3913867 IC50 5.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)C(C)(C)O3)n1 CHEMBL3657290 IC50 5.0 nM
COc1cc(C(=O)O)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657292 IC50 5.0 nM
CCN1Cc2cccc(Oc3nc(Nc4ccc(C(=O)NC5CCN(C)CC5)cc4OC)ncc3C(F)(F)F)c2C1=O CHEMBL3657300 IC50 5.0 nM
COc1cc(C(=O)NCC2CCCO2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657393 IC50 5.0 nM
CNC(=O)Cc1ccccc1CCc1nc(Nc2ccc(N3CCNCC3)cc2)ncc1C(F)(F)F CHEMBL3692180 Kd 5.0 nM
CN1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4cc(C(N)=O)ccn4)n3)cc2)CC1 CHEMBL3692199 Kd 5.0 nM
CCOP(=O)(Cc1ccc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(=O)NC)n2)cc1)OCC CHEMBL4207007 IC50 5.01 nM
c1ccc(CNc2nc(Nc3cc(C4CC4)[nH]n3)c3sccc3n2)cc1 CHEMBL1997924 pKi 5.012 nM
CP(C)(=O)c1ccccc1Nc1nc(Nc2ccc(C(=O)NC3CCNCC3)c(F)c2)nc2[nH]ccc12 CHEMBL4475488 IC50 5.1 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(CC(=O)N3CCOCC3)cc2)ncc1Cl CHEMBL4587135 IC50 5.17 nM
COc1cc(C(=O)NC2CCNCC2)ccc1Nc1nc(Nc2ccccc2P(C)(C)=O)c2cc[nH]c2n1 CHEMBL4448754 IC50 5.4 nM
C=CC(=O)NCCNc1c(NCc2ccc(Nc3ncc(Cl)c(NCc4cccnc4N(C)S(C)(=O)=O)n3)cc2)c(=O)c1=O CHEMBL4751164 IC50 5.5 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2)ncc1Cl CHEMBL545839 IC50 5.5 nM
CN1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ncccc4CC(N)=O)n3)cc2)CC1 CHEMBL3692198 Kd 5.6 nM
CN1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ccccc4CC(N)=O)n3)c(F)c2)CC1 CHEMBL3689081 IC50 5.6 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(CNc3c(NCCNC(=O)CCl)c(=O)c3=O)cc2)ncc1Cl CHEMBL4764885 IC50 5.6 nM
CN1CCN(c2ccc(Nc3nc(Oc4cccc5c4C(=O)CC5)c4cc[nH]c4n3)cc2F)CC1 CHEMBL5186851 IC50 5.64 nM
CCOP(=O)(Cc1ccc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(=O)NC)n2)cc1)N1CCOCC1 CHEMBL4211226 IC50 5.69 nM
CC(C)(C)NS(=O)(=O)c1cccc(-c2ccc3cnc(Nc4ccc(C5CCN(CC(N)=O)CC5)cc4)nn23)c1 CHEMBL1934337 IC50 5.7 nM
CN1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ncncc4CC(N)=O)n3)cc2)CC1 CHEMBL3692195 Kd 5.7 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3cccc(Cl)c3)n2)cc1 CHEMBL4853818 IC50 5.71 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3ccccc3OC)n2)cc1 CHEMBL4874518 IC50 5.73 nM
CN1Cc2cccnc2N(S(C)(=O)=O)C/C=C/c2cc(ccc2N2CCOCC2)Nc2ncc(C(F)(F)F)c1n2 CHEMBL3969464 IC50 5.75 nM
CCOc1cc(C(=O)NC2CCNCC2)ccc1Nc1nc(Nc2ccccc2P(C)(C)=O)c2cc[nH]c2n1 CHEMBL4546732 IC50 5.8 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3ccccc3F)n2)cc1 CHEMBL4865567 IC50 5.8 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2ccccc2C#N)n1 CHEMBL3665910 IC50 6.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2c(Cl)cccc2NS(C)(=O)=O)n1 CHEMBL3665940 IC50 6.0 nM
COc1cc(C(=O)N[C@@H]2CCN(C)C2)c(Cl)cc1Nc1ncc(C(F)(F)F)c(Oc2ccc(C)c3c2C(=O)CC3)n1 CHEMBL3657263 IC50 6.0 nM
COc1cc(C(=O)NC[C@@H]2CCCO2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657364 IC50 6.0 nM
Cc1cc(C(=O)NC2CCC(F)(F)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661429 IC50 6.0 nM
CCOP(=O)(CCCOc1ccc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(=O)NC)n2)cc1)OCC CHEMBL4218975 IC50 6.18 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3ccccc3Br)n2)cc1 CHEMBL4850002 IC50 6.29 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 6.31 nM
Cc1cc(Nc2nc(Oc3cccc4c3C(=O)CC4)c3cc[nH]c3n2)ccc1N1CCN(C2COC2)CC1 CHEMBL5192647 IC50 6.32 nM
COc1c(Nc2ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)ccc2c1CCC[C@@H](N1CCN(C)CC1)C2 CHEMBL3980825 IC50 6.5 nM
COc1cc(C(=O)NC2CCNCC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL5429220 IC50 6.7 nM
CP(C)(=O)c1ccccc1Nc1nc(Nc2ccc(C(=O)NC3CCNCC3)cc2)nc2[nH]ccc12 CHEMBL4453086 IC50 6.8 nM
COc1c(Nc2ncc(Cl)c(Nc3ccccc3-n3cccn3)n2)ccc2c1CCCC(N1CCN(CCO)CC1)C2 CHEMBL3934099 IC50 7.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2ccccc2C#N)n1 CHEMBL3665911 IC50 7.0 nM
COc1cc(C(=O)N[C@@H]2CCN(C)C[C@H]2F)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657255 IC50 7.0 nM
COc1cc(C(=O)NC2CCOCC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657267 IC50 7.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)C(C)(C)O3)n1 CHEMBL3657291 IC50 7.0 nM
COc1cc(Nc2ncc3scc(-c4cccc(NS(C)(=O)=O)c4)c3n2)cc(OC)c1OC CHEMBL4851157 IC50 7.0 nM
CCN1CCN(c2ccc(Nc3ncc4scc(-c5cccc(NS(C)(=O)=O)c5)c4n3)cc2)CC1 CHEMBL4846921 IC50 7.0 nM
Cc1cc(N2CCN(C)CC2)ccc1Nc1nc(Oc2cccc3c2C(=O)CC3)c2cc[nH]c2n1 CHEMBL5199941 IC50 7.13 nM
CN1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4nccnc4CC(N)=O)n3)cc2)CC1 CHEMBL3692192 IC50 7.2 nM
COc1cc(C2CCNCC2)ccc1Nc1ncc(C(F)(F)F)c(CCc2cccc(C(N)=O)c2)n1 CHEMBL3689073 IC50 7.2 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(OCC(=O)N3CCOCC3)cc2)ncc1Cl CHEMBL4580829 IC50 7.28 nM
CCOC(=O)C1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)cc2)CC1 CHEMBL5188293 IC50 7.553 nM
Cc1ccc(CCc2nc(Nc3ccc(N4CCNCC4)cc3)ncc2C(F)(F)F)cc1C(N)=O CHEMBL3692184 IC50 7.7 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 7.943 nM
COC(=O)c1ccccc1Oc1nc(Nc2ccc(C(=O)NC3CCN(C)CC3)cc2OC)ncc1C(F)(F)F CHEMBL3665875 IC50 8.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc(Cl)c2C#N)n1 CHEMBL3665904 IC50 8.0 nM
CCc1cc(C(=O)NC2CCN(C(C)C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657297 IC50 8.0 nM
COc1cc(C(=O)NC2CCC(F)(F)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661434 IC50 8.0 nM
CS(=O)(=O)Nc1cccc(-c2csc3cnc(Nc4ccc(N5CCOCC5)cc4)nc23)c1 CHEMBL4873104 IC50 8.0 nM
COc1c(Nc2ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)ccc2c1CCC[C@H](N1CCN(C)CC1)C2 CHEMBL3936443 IC50 8.5 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(C(=O)N3CCN(C(=S)SCCN(C)C)CC3)cc2)ncc1Cl CHEMBL4469292 IC50 8.57 nM
CN1Cc2ccccc2N(S(C)(=O)=O)CCCCC(=O)N2CCc3cc(ccc32)Nc2ncc(C(F)(F)F)c1n2 CHEMBL3899046 IC50 8.6 nM
CP(C)(=O)c1ccccc1Nc1nc(Nc2ccc(C(=O)NC3CCNCC3)cc2)ncc1Cl CHEMBL5406670 IC50 8.7 nM
CNC(=O)c1ccccc1Nc1c(C(F)(F)F)cnc2[nH]c(-c3ccc(N4CCOCC4)nc3)cc12 CHEMBL2315566 Kd 9.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc(C)c2C#N)n1 CHEMBL3665931 IC50 9.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C[C@@H]2F)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657256 IC50 9.0 nM
O=C1Cc2c(ccc(Nc3ncc(C(F)(F)F)c(Oc4cccc5c4C(=O)CC5)n3)c2F)N1 CHEMBL3657270 IC50 9.0 nM
CCc1cc(C(=O)NC)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657287 IC50 9.0 nM
CCc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657295 IC50 9.0 nM
CCc1cc(C(=O)NC2CCCN(C)C2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657299 IC50 9.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)CCO3)n1 CHEMBL3657413 IC50 9.0 nM
COc1nc(N2CCN(C)CC2)ccc1Nc1nc(Oc2cccc3c2C(=O)CC3)c2cc[nH]c2n1 CHEMBL5188877 IC50 9.05 nM
CP(C)(=O)c1ccccc1Nc1nc(Nc2ccc(C(=O)N[C@H]3CCCNC3)cc2)nc2[nH]ccc12 CHEMBL4573707 IC50 9.1 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 9.12 nM
CCS(=O)(=O)N1CCCCC(=O)N2CCc3cc(ccc32)Nc2ncc(C(F)(F)F)c(n2)NCc2ccccc21 CHEMBL3908093 IC50 9.2 nM
COc1c(Nc2ncc(Cl)c(Nc3ccccc3NS(C)(=O)=O)n2)ccc2c1CCCC(N1CCN(CCO)CC1)C2 CHEMBL3953048 IC50 9.3 nM
CP(C)(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCNCC3)cc2)nc2[nH]ccc12 CHEMBL4514956 IC50 9.3 nM
CCN1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(Cc4ccccc4C(N)=O)n3)c(OC)c2)CC1 CHEMBL3689075 IC50 9.4 nM
COc1cc(C(=O)NC2CCNCC2)c(F)cc1Nc1nc(Nc2ccccc2P(C)(C)=O)c2cc[nH]c2n1 CHEMBL4550782 IC50 9.4 nM
COc1cc(N2C[C@@H]3C[C@H]2CO3)ccc1Nc1nc(Oc2cccc3c2C(=O)CC3)c2cc[nH]c2n1 CHEMBL5194483 IC50 9.6 nM
CP(C)(=O)c1ccccc1Nc1nc(Nc2ccc(C(=O)NC3CCC(O)CC3)cc2)ncc1Cl CHEMBL5402799 IC50 9.6 nM
CN(c1cccc(CNc2nc(Nc3ccc(OCCOCCOCCOCCOCCC(=O)NCCOc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc3)ncc2C(F)(F)F)c1)S(C)(=O)=O CHEMBL4541275 IC50 9.7 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2ccccc2N(C)S(C)(=O)=O)n1 CHEMBL3665936 IC50 10.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2ccc(Cl)cc2NS(C)(=O)=O)n1 CHEMBL3665941 IC50 10.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2ccc(Cl)c3c2C(=O)CC3C)n1 CHEMBL3657257 IC50 10.0 nM
COc1cc(C(=O)NC(C)(C)C)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657266 IC50 10.0 nM
O=C1Cc2c(ccc(Nc3ncc(C(F)(F)F)c(Oc4cccc5c4C(=O)OC5)n3)c2F)N1 CHEMBL3657276 IC50 10.0 nM
CCc1cc(C(=O)NC2CCN(CC)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657296 IC50 10.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)CCO3)n1 CHEMBL3661419 IC50 10.0 nM
CCN1CCN(c2ccc(Nc3ncc4scc(-c5ccccc5)c4n3)cc2)CC1 CHEMBL4846553 IC50 10.0 nM
CS(=O)(=O)N1C/C=C/c2cccc(c2)Nc2ncc(C(F)(F)F)c(n2)NCc2cccnc21 CHEMBL3961368 IC50 10.2 nM
Cc1cc(Nc2nc(Nc3ccccc3P(C)(C)=O)c3cc[nH]c3n2)ccc1C(=O)NC1CCNCC1 CHEMBL4457562 IC50 10.3 nM
Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3P(C)(C)=O)n2)ccc1C(=O)NC1CCC(O)CC1 CHEMBL5420280 IC50 10.3 nM
CN1CCN(c2ccc(Nc3nc(Oc4cccc5c4C(=O)CC5)c4cc[nH]c4n3)cc2)CC1 CHEMBL5188174 IC50 10.52 nM
CCOP(=O)(CCCOc1ccc(Nc2ncc(Cl)c(Nc3ccccc3C(=O)NC)n2)cc1)OCC CHEMBL4209502 IC50 10.69 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOc2ccc(Nc3ncc(C(F)(F)F)c(NCc4cccc(N(C)S(C)(=O)=O)c4)n3)cc2)C(C)(C)C)cc1 CHEMBL4449796 IC50 10.7 nM
CP(C)(=O)c1ccccc1Nc1nc(Nc2ccc(C(=O)NC3CCOCC3)cc2)ncc1Cl CHEMBL5414280 IC50 10.8 nM
COc1cc(C(=O)NC2CC2)ccc1Nc1nc(Oc2cccc3c2C(=O)CC3)c2cc[nH]c2n1 CHEMBL5208299 IC50 10.86 nM
Cc1cc(-c2ccccc2N(C)S(C)(=O)=O)n2nc(Nc3ccc(C4CCN(CC(N)=O)CC4)cc3)ncc12 CHEMBL1934352 IC50 11.0 nM
COC(=O)c1ccccc1Oc1nc(Nc2cc(F)c(C(=O)NC3CCN(C)CC3)cc2OC)ncc1C(F)(F)F CHEMBL3665869 IC50 11.0 nM
O=C1Cc2cc(Nc3ncc(C(F)(F)F)c(Oc4cccc5c4C(=O)CC5)n3)ccc2N1 CHEMBL3657271 IC50 11.0 nM
CCc1cc(C(=O)NOC)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657288 IC50 11.0 nM
Cc1nc2ccc(Nc3ncc(C(F)(F)F)c(Oc4cccc5c4C(=O)CC5)n3)cc2n1C CHEMBL3657293 IC50 11.0 nM
COc1cc(OC2CCOCC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657340 IC50 11.0 nM
COc1cc(C(=O)NC2CCCCC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3661433 IC50 11.0 nM
NC(=O)Cc1cncnc1CCc1nc(Nc2ccc(C3CCNCC3)cc2)ncc1C(F)(F)F CHEMBL3692194 IC50 11.0 nM
C[C@@]1(C(=O)Nc2ccc(F)nc2)CCCN1c1nc(Nc2cc(C3CC3)n[nH]2)c2cccn2n1 CHEMBL575448 Kd apparent 11.0 nM
CC(=O)N1CCN(c2ccc(Nc3ncc(C(F)(F)F)c(N4Cc5cccc(N(C)S(C)(=O)=O)c5C4)n3)cc2)CC1 CHEMBL4476226 IC50 11.0 nM
CCN1CCN(c2ccc(Nc3ncc4scc(-c5cccc(S(=O)(=O)NC)c5)c4n3)cc2)CC1 CHEMBL4874196 IC50 11.0 nM
CN(c1cccc(CNc2nc(Nc3ccc(OCCCOCCC(=O)NCCOc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc3)ncc2C(F)(F)F)c1)S(C)(=O)=O CHEMBL4567809 IC50 11.3 nM
CN1CCN(c2ccc(Nc3nc4c(NCc5ccccc5N(C)S(C)(=O)=O)cccn4n3)cc2)CC1 CHEMBL3642370 IC50 11.39 nM
O=C1CCCNS(=O)(=O)c2ncccc2CNc2nc(ncc2C(F)(F)F)Nc2ccc3c(c2)CCN13 CHEMBL3912281 IC50 11.4 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccccc3[N+](=O)[O-])n2)cc1 CHEMBL4849851 IC50 11.69 nM
COc1cc(N2C[C@@H](C)O[C@@H](C)C2)ccc1Nc1nc(Oc2cccc3c2C(=O)CC3)c2cc[nH]c2n1 CHEMBL5177037 IC50 11.95 nM
CNC(=O)c1ccccc1Nc1c(C(F)(F)F)cnc2[nH]c(-c3cccnc3)cc12 CHEMBL2315563 Kd 12.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2ccccc2-c2csnn2)n1 CHEMBL3665901 IC50 12.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2ccccc2N(C)S(C)(=O)=O)n1 CHEMBL3665938 IC50 12.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cc(C)ccc2NS(C)(=O)=O)n1 CHEMBL3665943 IC50 12.0 nM
COc1cc(-n2ccnn2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657272 IC50 12.0 nM
COc1cc(C(=O)NC2CCN(c3ncccn3)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657286 IC50 12.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2cccc(NC(C)=O)c2)nc2[nH]cc(F)c12 CHEMBL4846334 IC50 12.0 nM
CS(=O)(=O)Nc1cccc(-c2csc3cnc(Nc4ccc(N5CCNCC5)cc4)nc23)c1 CHEMBL4877875 IC50 12.0 nM
CCN1CCN(c2ccc(Nc3ncc4scc(-c5ccccn5)c4n3)cc2)CC1 CHEMBL4854620 IC50 12.0 nM
CCN1CCN(c2ccc(Nc3ncc4scc(-c5cccc(OC)c5)c4n3)cc2)CC1 CHEMBL4853724 IC50 12.0 nM
O=C1CCc2cccc(Oc3nc(Nc4ccc(N5CCOCC5)cc4)nc4[nH]ccc34)c21 CHEMBL5177788 IC50 12.23 nM
CN1CCN(c2ccc(-c3cnc4c(c3)N(Cc3cc(Cl)ccc3C(F)(F)F)CCN4)cn2)CC1 CHEMBL1164180 pKi 12.59 nM
COc1cc2c(cc1F)C(c1ccccc1Cl)=Nc1c(n[nH]c1C)N2 CHEMBL1980391 pKi 12.59 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOc2ccc(Nc3ncc(C(F)(F)F)c(NCc4cccc(N(C)S(C)(=O)=O)c4)n3)cc2)C(C)(C)C)cc1 CHEMBL4560289 IC50 12.7 nM
CN(c1ccccc1CNc1cccn2nc(Nc3ccc(OCCN4CCCC4)cc3)nc12)S(C)(=O)=O CHEMBL3642373 IC50 12.96 nM
CNC(=O)Cc1ccccc1CCc1nc(Nc2cccc(N3CCN(C)CC3)c2)ncc1C(F)(F)F CHEMBL3692183 IC50 13.0 nM
CN1CCN(c2ccc(Nc3nc(NCc4cccnc4N(C)S(C)(=O)=O)c4c(F)c[nH]c4n3)cc2)CC1 CHEMBL4847194 IC50 13.0 nM
CCN1CCN(c2cccc(Nc3ncc4scc(-c5cccc(NS(C)(=O)=O)c5)c4n3)c2)CC1 CHEMBL4857298 IC50 13.0 nM
CN1CCC(c2ccc(Nc3nc4c(NCc5ccccc5N(C)S(C)(=O)=O)cccn4n3)cc2)CC1 CHEMBL3642372 IC50 13.58 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCCCC(=O)Nc4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2OC)ncc1Cl CHEMBL5207219 IC50 13.6 nM
CN(c1ccccc1-c1ccc2cnc(Nc3ccc(C4CCN(CC(N)=O)CC4)cc3)nn12)S(C)(=O)=O CHEMBL1934336 IC50 14.0 nM
CN(c1ncccc1-c1ccc2cnc(Nc3ccc(C4CCN(CC(N)=O)CC4)cc3)nn12)S(C)(=O)=O CHEMBL1934344 IC50 14.0 nM
CN1Cc2ccncc2N(S(C)(=O)=O)C/C=C/c2cc(ccc2N2CCOCC2)Nc2ncc(C(F)(F)F)c1n2 CHEMBL3977870 IC50 14.0 nM
CN1Cc2cccc(Oc3nc(Nc4ccc(O[C@H]5CCOC5)cc4)ncc3C(F)(F)F)c2C1=O CHEMBL3657338 IC50 14.0 nM
NC(=O)Cc1cccnc1CCc1nc(Nc2ccc(C3CCCNC3)cc2)ncc1C(F)(F)F CHEMBL3692204 IC50 14.0 nM
NC(=O)Cc1nccnc1CCc1nc(Nc2ccc(C3CCNCC3)cc2)ncc1C(F)(F)F CHEMBL3692191 Kd 14.0 nM
CP(C)(=O)c1ccccc1Nc1nc(Nc2ccc(C(=O)NC3CCNCC3)cc2F)nc2[nH]ccc12 CHEMBL4454761 IC50 14.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2cccc(CNC(C)=O)c2)nc2[nH]cc(F)c12 CHEMBL4874082 IC50 14.0 nM
CP(C)(=O)c1ccccc1Nc1nc(Nc2ccc(C(=O)N[C@H]3CCNC3)cc2)ncc1Cl CHEMBL5434288 IC50 14.3 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCCOc2ccc(Nc3ncc(C(F)(F)F)c(NCc4cccc(N(C)S(C)(=O)=O)c4)n3)cc2)C(C)(C)C)cc1 CHEMBL4558994 IC50 14.5 nM
CN1CCN(c2cccc(Nc3nc4c(NCc5ccccc5N(C)S(C)(=O)=O)cccn4n3)c2)CC1 CHEMBL3642371 IC50 14.63 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOc2ccc(Nc3ncc(C(F)(F)F)c(NCc4cccc(N(C)S(C)(=O)=O)c4)n3)cc2)C(C)(C)C)cc1 CHEMBL4464368 IC50 14.7 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCCCC(=O)Nc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2OC)ncc1Cl CHEMBL5172031 IC50 14.9 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(OCC2CCCO2)n1 CHEMBL3665919 IC50 15.0 nM
COc1cc(C(=O)N[C@H]2CCN(C)C2)c(Cl)cc1Nc1ncc(C(F)(F)F)c(Oc2ccc(C)c3c2C(=O)CC3)n1 CHEMBL3657264 IC50 15.0 nM
NC(=O)c1cccc(CCc2nc(Nc3ccc(CN4CCNCC4)cc3)ncc2C(F)(F)F)c1 CHEMBL3692202 IC50 15.0 nM
COc1ccc(Nc2nc(NCc3cccnc3N(C)S(C)(=O)=O)c3c(F)c[nH]c3n2)cc1OC CHEMBL4878089 IC50 15.0 nM
COc1cc(Nc2ncc3scc(-c4ccccc4N(C)S(C)(=O)=O)c3n2)cc(OC)c1OC CHEMBL4846093 IC50 15.0 nM
CP(C)(=O)c1ccccc1Nc1nc(Nc2ccc(C(=O)NC3CCC(O)CC3)c(F)c2)ncc1Cl CHEMBL5433832 IC50 15.2 nM
CNC(=O)c1ccc(Nc2nc(Nc3ccccc3P(C)(C)=O)c3cc[nH]c3n2)cc1 CHEMBL4466781 IC50 15.5 nM
COc1cc(C(=O)NC2CCC(O)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL5394494 IC50 15.7 nM
CP(C)(=O)c1ccccc1Nc1nc(Nc2ccc(C(=O)NC3CCNCC3)c(F)c2)ncc1Cl CHEMBL5433341 IC50 15.8 nM
FC(F)(F)c1cnc(Nc2ccc3[nH]ncc3c2)nc1NCc1ccccn1 CHEMBL471526 IC50 16.0 nM
Cc1nc([C@](C)(O)CO)sc1-c1cnc(N)c(O[C@H](C)c2cc(F)ccc2-n2nccn2)c1 CHEMBL3128069 IC50 16.0 nM
COc1cccc(COc2nc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)ncc2C(F)(F)F)c1 CHEMBL3665917 IC50 16.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2ccc(Cl)c3c2C(=O)CC3C)n1 CHEMBL3657258 IC50 16.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1nccc(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657349 IC50 16.0 nM
CS(=O)(=O)Nc1cccc(-c2csc3cnc(Nc4ccc(N5CCC(O)CC5)cc4)nc23)c1 CHEMBL4872520 IC50 16.0 nM
C=CC(=O)NCCNc1c(NCc2ccc(Nc3ncc(Cl)c(NCc4cccc(S(C)(=O)=O)c4)n3)cc2)c(=O)c1=O CHEMBL4792798 IC50 16.3 nM
CP(C)(=O)c1ccccc1Nc1nc(Nc2ccc(C(=O)NC3CCOCC3)cc2)nc2[nH]ccc12 CHEMBL4472514 IC50 16.7 nM
CP(C)(=O)c1ccccc1Nc1nc(Nc2ccc(C(=O)N[C@@H]3CCNC3)cc2)ncc1Cl CHEMBL5414496 IC50 16.7 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCCCC(=O)NCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2OC)ncc1Cl CHEMBL5201498 IC50 16.9 nM
COc1cc(Nc2ncc3ccc(-c4ccccc4)n3n2)cc(OC)c1OC CHEMBL1822511 IC50 17.0 nM
C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21 CHEMBL3286830 IC50 17.0 nM
CS(=O)(=O)N1CCCCC(=O)N2CCc3cc(ccc32)Nc2ncc(C(F)(F)F)c(n2)NCc2cccnc21 CHEMBL3889951 IC50 17.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc(CC(N)=O)c2)n1 CHEMBL3665877 IC50 17.0 nM
CCc1cc(C(=O)N[C@H]2CC[C@H](N3CCOCC3)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657298 IC50 17.0 nM
COc1cc(Nc2nc(NCc3cccnc3N(C)S(C)(=O)=O)c3c(F)c[nH]c3n2)cc(OC)c1OC CHEMBL4864127 IC50 17.0 nM
CNC(=O)c1ccc(Nc2nc(NCc3ccccc3N(C)S(C)(=O)=O)c3cc[nH]c3n2)cc1 CHEMBL4443454 IC50 17.1 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCCCC(=O)Nc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)CC3)cc2OC)ncc1Cl CHEMBL5175069 IC50 17.1 nM
CC(C)Oc1cc(-n2cnc3ccc(N[C@@H](C)c4ccc(F)cn4)nc32)n[nH]1 CHEMBL2151321 IC50 17.2 nM
CN1CCC(NC(=O)c2ccc(Nc3nc(Nc4ccccc4P(C)(C)=O)c4cc[nH]c4n3)cc2)CC1 CHEMBL4445320 IC50 17.2 nM
CP(C)(=O)c1ccccc1Nc1nc(Nc2ccc(C(=O)NC3CCC(O)CC3)cc2F)ncc1Cl CHEMBL5415868 IC50 17.5 nM
CN1Cc2ccc(Nc3nc4c(NCc5ccccc5N(C)S(C)(=O)=O)cccn4n3)cc2C1 CHEMBL3642388 IC50 17.76 nM
CN(C)CCN(Cc1ccc(Cl)cc1)c1ccc2ccccc2n1 CHEMBL3265344 Kd 18.0 nM
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC)cc1N(C)CCN(C)C CHEMBL4473365 IC50 18.0 nM
COc1cc(C(=O)NCCOCCOCCOCCC(=O)Nc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL4781145 IC50 18.0 nM
COc1cc(Nc2ncc3scc(-c4ccccn4)c3n2)cc(OC)c1OC CHEMBL4861088 IC50 18.0 nM
CN(C)c1ccc(Nc2ncc3scc(-c4cccc(NS(C)(=O)=O)c4)c3n2)cc1 CHEMBL4878656 IC50 18.0 nM
CCN1CCN(c2ccc(Nc3ncc4scc(-c5cccc(S(C)(=O)=O)c5)c4n3)cc2)CC1 CHEMBL4849384 IC50 18.0 nM
CN(c1ccccc1CNc1cccn2nc(Nc3ccc4c(c3)CCC(N3CCOCC3)CC4)nc12)S(C)(=O)=O CHEMBL3642420 IC50 18.18 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc(NS(C)(=O)=O)cc3)n2)cc1 CHEMBL4869055 IC50 18.19 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCCOCCC(=O)NCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2OC)ncc1Cl CHEMBL5170596 IC50 18.4 nM
O=C1Cc2cc(Nc3ncc(C(F)(F)F)c(NCc4ccccn4)n3)ccc2N1 CHEMBL471357 IC50 19.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3nc[nH]c23)n1 CHEMBL3665886 IC50 19.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2ccccc2-c2ccon2)n1 CHEMBL3665929 IC50 19.0 nM
COc1cc(C(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL4778548 IC50 19.0 nM
CCN1C(=O)c2nc(C)sc2N(C)c2nc(Nc3ccc(N4CCC(N5CCN(C)CC5)CC4)cc3OC)ncc21 CHEMBL4777901 IC50 19.0 nM
CP(C)(=O)c1ccccc1Nc1nc(Nc2ccc(C(=O)NCC3CCNCC3)cc2)ncc1Cl CHEMBL5427011 IC50 19.7 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2ccc(Cl)cc2C#N)n1 CHEMBL3665907 IC50 20.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc2c(n1)N(C)c1sc(C)nc1C(=O)N2C CHEMBL4752723 IC50 20.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCOCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2OC)ncc1Cl CHEMBL5191088 IC50 20.2 nM
CN1CCN(c2ccc(Nc3nc(Oc4cccc5c4C(=O)CC5)c4cc[nH]c4n3)cc2C#N)CC1 CHEMBL5183206 IC50 20.55 nM
COc1cc(C(=O)NC2CCNCC2)ccc1Nc1nc(Nc2ccccc2P(C)(C)=O)c2sccc2n1 CHEMBL4483692 IC50 20.6 nM
O=C1NCc2cc(Nc3nc(Oc4cccc5c4C(=O)CC5)c4cc[nH]c4n3)ccc21 CHEMBL5179693 IC50 20.64 nM
COc1cc(C2CCN(CC(N)=O)CC2)ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1 CHEMBL1934334 IC50 21.0 nM
CS(=O)(=O)Nc1cccc(-c2ccc3cnc(Nc4ccc(C5CCN(CC(N)=O)CC5)cc4)nn23)c1 CHEMBL1934339 IC50 21.0 nM
CS(=O)(=O)N1Cc2cccc(c2)C(=O)N2CCc3cc(ccc32)Nc2ncc(C(F)(F)F)c(n2)NCc2cccnc21 CHEMBL3939286 IC50 21.0 nM
CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)nc2[nH]cc(Cl)c12)S(C)(=O)=O CHEMBL4870488 IC50 21.0 nM
CC(=O)Nc1cccc(Nc2nc(NCc3cccnc3N(C)S(C)(=O)=O)c3c(F)c[nH]c3n2)c1 CHEMBL4850042 IC50 21.0 nM
CCN1CCN(c2ccc(Nc3ncc4scc(-c5cccc([N+](=O)[O-])c5)c4n3)cc2)CC1 CHEMBL4861397 IC50 21.0 nM
CCN1CCN(c2ccc(Nc3ncc4scc(-c5cccc(N(C)S(C)(=O)=O)c5)c4n3)cc2)CC1 CHEMBL4862392 IC50 21.0 nM
CP(C)(=O)c1ccccc1Nc1nc(Nc2cnn(CC(=O)N3CCOCC3)c2)nc2[nH]ccc12 CHEMBL4466313 IC50 21.1 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc(NC(C)=O)cc3)n2)cc1 CHEMBL4877387 IC50 21.22 nM
CN1CCN(c2ccc(Nc3nc4c(OCc5ccccc5N(C)S(C)(=O)=O)cccn4n3)cc2)CC1 CHEMBL3642416 IC50 21.81 nM
CN1CCN(c2ccc(Nc3nc(Nc4ccccc4P(C)(C)=O)c4cc[nH]c4n3)cc2)CC1 CHEMBL4548762 IC50 21.9 nM
CC(C)c1cc(CNc2nc(Nc3cc(C4CC4)[nH]n3)cc(N3CCN(C)CC3)n2)on1 CHEMBL3545085 Kd apparent 22.0 nM
CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)nc2[nH]cc(F)c12)S(C)(=O)=O CHEMBL4846273 IC50 22.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2)CC(=O)N3)nc2[nH]cc(F)c12 CHEMBL4864492 IC50 22.0 nM
CCN1CCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ncccc4CC(N)=O)n3)cc2)CC1 CHEMBL3692203 IC50 23.0 nM
COc1cc(C(=O)NC2CCNCC2)ccc1Nc1nc(Nc2ccccc2P(C)(C)=O)c2ccsc2n1 CHEMBL4461902 IC50 23.0 nM
CCN1c2nc(Nc3ccc(N4CCC(N5CCN(C)CC5)CC4)cc3OC)ncc2N(C)C(=O)c2nc(C)sc21 CHEMBL4749193 IC50 23.0 nM
CC(=O)NCc1cccc(Nc2nc(NCc3cccnc3N(C)S(C)(=O)=O)c3c(F)c[nH]c3n2)c1 CHEMBL4854959 IC50 23.0 nM
COc1cc(N2CCOCC2)ccc1Nc1nc(NCc2cccnc2N(C)S(C)(=O)=O)c2c(F)c[nH]c2n1 CHEMBL4874516 IC50 23.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)nc2[nH]cc(F)c12 CHEMBL4846781 IC50 23.0 nM
COCCn1cc(Nc2nc(Nc3ccccc3P(C)(C)=O)c3cc[nH]c3n2)cn1 CHEMBL4529571 IC50 23.1 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Nc3cccc(OC)c3)n2)cc1 CHEMBL4858762 IC50 23.21 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCCCCC(=O)NCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2OC)ncc1Cl CHEMBL5173827 IC50 23.7 nM
CN(c1ncccc1CNc1c(C(F)(F)F)cnc2[nH]c(-c3ccc(F)cc3)cc12)S(C)(=O)=O CHEMBL2315584 Kd 24.0 nM
Cc1cc(-c2cc3c(NCc4cccnc4N(C)S(C)(=O)=O)c(C#N)cnc3[nH]2)ccn1 CHEMBL2315583 Kd 24.0 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc(N)cc3)n2)cc1 CHEMBL4863844 IC50 24.19 nM
COc1ccccc1-c1csc2cnc(Nc3cc(F)c(C(=O)NC4CCNCC4)cc3F)nc12 CHEMBL4799952 IC50 24.2 nM
CS(=O)(=O)c1cccc(-c2ccc3cnc(Nc4ccc(C5CCN(CC(N)=O)CC5)cc4)nn23)c1 CHEMBL1934343 IC50 25.0 nM
COc1c(Nc2ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)ccc2c1CC[C@@H](N1CCOCC1)CC2 CHEMBL2064666 IC50 25.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc(C(N)=O)c2)n1 CHEMBL3665876 IC50 25.0 nM
Cc1cc(-n2cc(C(=O)N3CCO[C@@H](C)C3)c3ccc(O[C@@H](C)c4ccc(F)cn4)nc32)n[nH]1 CHEMBL4440381 IC50 25.0 nM
COc1ccc(-c2ccc(NC(=O)Nc3cccc(Br)c3)cc2)c2c(N)noc12 CHEMBL271381 pKi 25.12 nM
COC(C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 CHEMBL1981047 pKi 25.12 nM
COc1cc(-c2ccc3c(c2)NC(=O)c2ccc(-c4ccccc4NS(C)(=O)=O)cc2N3)cc(OC)c1OC CHEMBL1984038 pKi 25.12 nM
CCC(Oc1ccc(Nc2ncc(Cl)c(Nc3ccccc3C(=O)NC)n2)cc1)C(=O)N1CCOCC1 CHEMBL4461676 IC50 25.6 nM
COc1ccccc1-c1csc2cnc(Nc3ccc(C(=O)NC4CCNCC4)c(C)c3)nc12 CHEMBL4786939 IC50 25.7 nM
O=C(O)c1ccc(Nc2ncc(C(F)(F)F)c(Oc3cccc4c3C(=O)CC4)n2)cc1 CHEMBL3657301 IC50 26.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657314 IC50 26.0 nM
CN(c1ncccc1CNc1nc(Nc2ccc(N3CCOCC3)cc2)nc2[nH]cc(F)c12)S(C)(=O)=O CHEMBL4874144 IC50 26.0 nM
COc1cc(Nc2ncc3scc(-c4cccnc4)c3n2)cc(OC)c1OC CHEMBL4858365 IC50 26.0 nM
CP(C)(=O)c1ccccc1Nc1nc(Nc2cnn(C3CCNCC3)c2)nc2[nH]ccc12 CHEMBL4468872 IC50 26.2 nM
COc1ccccc1-c1csc2cnc(Nc3ccc(C(=O)NC4CCNCC4)cc3C)nc12 CHEMBL4786967 IC50 26.5 nM
CS(=O)(=O)N1CCCC(=O)N2CCc3cc(ccc32)Nc2ncc(C(F)(F)F)c(n2)NCc2cccnc21 CHEMBL3914036 IC50 27.0 nM
CCN(c1ccccc1Oc1nc(Nc2ccc(C(=O)NC3CCN(C)CC3)cc2OC)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL3665937 IC50 27.0 nM
COc1cc(C(=O)NC2CCNCC2)ccc1Nc1ncc2scc(-c3ccccc3OC)c2n1 CHEMBL4787717 IC50 27.2 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1nc(Oc2cccc3c2C(=O)CC3)c2sccc2n1 CHEMBL5176072 IC50 27.41 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(CC(=O)OCCCCCCCCOc3no[n+]([O-])c3S(=O)(=O)c3ccccc3)cc2)ncc1Cl CHEMBL5436039 IC50 27.44 nM
CP(C)(=O)c1ccccc1Nc1nc(Nc2ccc(C(=O)NC3CCNCC3)cc2F)ncc1Cl CHEMBL5431569 IC50 27.5 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCCCCC(=O)Nc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2OC)ncc1Cl CHEMBL5203043 IC50 27.6 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1nc(-n2cnc3ccccc32)c2cc[nH]c2n1 CHEMBL5189374 IC50 27.63 nM
COc1cc(OC2CCN(C)C2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657375 IC50 28.0 nM
COc1ccccc1-c1csc2cnc(Nc3ccc(C(=O)NC4CCNCC4)c(F)c3)nc12 CHEMBL4785582 IC50 28.2 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3ccc(OC)cc3)n2)cc1 CHEMBL4849923 IC50 28.73 nM
Cc1cc(C(=O)NC2CCNCC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL5396970 IC50 28.8 nM
COc1cc(Nc2ncc3ccn(-c4cccc(C(=O)NCCN)c4)c3n2)cc(OC)c1OC CHEMBL207084 IC50 29.0 nM
COc1ccc(Nc2ncc(C(C)C)c(Oc3cccc4c3C(=O)CC4)n2)c(OC)c1 CHEMBL3657327 IC50 29.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc(F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657336 IC50 29.0 nM
CCN1CCN(c2ccc(Nc3ncc4scc(-c5cnc6ccccc6c5)c4n3)cc2)CC1 CHEMBL4860735 IC50 29.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCCCCCCC(=O)NCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2OC)ncc1Cl CHEMBL5178915 IC50 29.6 nM
CN1CCN(c2ccc(Nc3nc4c(NCc5cccnc5N(C)S(C)(=O)=O)cccn4n3)cc2)CC1 CHEMBL3642345 IC50 29.99 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2ccc(C(N)=O)cc2)n1 CHEMBL3665872 IC50 30.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2ccc(Br)cc2C#N)n1 CHEMBL3665902 IC50 30.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cc(Br)ccc2C#N)n1 CHEMBL3665903 IC50 30.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C)c1sc(C)nc1C(=O)N2C CHEMBL4793090 IC50 30.0 nM
CS(=O)(=O)Nc1cccc(-c2csc3cnc(Nc4ccccc4)nc23)c1 CHEMBL4871809 IC50 30.0 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Nc3cccc(N)c3)n2)cc1 CHEMBL4864858 IC50 30.77 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc(F)c2C#N)n1 CHEMBL3665905 IC50 31.0 nM
CCN1CCN(c2ccc(Nc3ncc4scc(-c5cccnc5)c4n3)cc2)CC1 CHEMBL4867151 IC50 31.0 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc(F)cc3)n2)cc1 CHEMBL4847034 IC50 31.25 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(CC(=O)OCCCCCCCOc3no[n+]([O-])c3S(=O)(=O)c3ccccc3)cc2)ncc1Cl CHEMBL5429885 IC50 31.36 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCCCCCC(=O)NCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2OC)ncc1Cl CHEMBL5181306 IC50 31.4 nM
Cc1cc(N2CCOCC2)cc2[nH]c(-c3c(NCC(O)c4ccccc4)cc[nH]c3=O)nc12 CHEMBL1992527 pKi 31.62 nM
CC(C)Oc1cc(Nc2nc(NC(C)c3ccc(F)cn3)ncc2Cl)n[nH]1 CHEMBL2007421 pKi 31.62 nM
Cc1cc(C(=O)NC2CCC(O)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL5417189 IC50 31.7 nM
COc1cc(N2CCOCC2)ccc1Nc1nc(NCc2ccccc2N(C)S(C)(=O)=O)c2cc[nH]c2n1 CHEMBL4440758 IC50 31.9 nM
Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3P(C)(C)=O)n2)ccc1C(=O)NC1CCNCC1 CHEMBL5431438 IC50 31.9 nM
CCc1nc2c(s1)N(C)c1nc(Nc3ccc(N4CCC(N5CCN(C)CC5)CC4)cc3OC)ncc1N(C)C2=O CHEMBL4750613 IC50 32.0 nM
COc1cc(N2CCN(C)CC2)c(C)cc1Nc1ncc2c(n1)N(C)c1sc(C)nc1C(=O)N2C CHEMBL4784924 IC50 32.0 nM
CN(c1ncccc1CNc1nc(Nc2ccccc2)nc2[nH]cc(F)c12)S(C)(=O)=O CHEMBL4852626 IC50 32.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(C(=O)N3CCN(C(=S)SCCN(C)C)CC3)cc2)ncc1F CHEMBL4438250 IC50 32.7 nM
CCS(=O)(=O)Nc1ccc2c(c1)/C(=C(/Nc1ccc(CN3CCCCC3)cc1)c1ccccc1)C(=O)N2 CHEMBL514409 Kd 33.0 nM
NC(=O)CN1CCC(c2ccc(Nc3ncc4ccc(-c5cccc(CO)c5)n4n3)cc2)CC1 CHEMBL1934341 IC50 33.0 nM
CN(c1ncccc1CNc1c(C(F)(F)F)cnc2[nH]c(-c3ccc(F)cc3)nc12)S(C)(=O)=O CHEMBL2315572 Kd 33.0 nM
CO[C@@H](C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 CHEMBL402548 Kd apparent 33.0 nM
CCN1CCN(c2ccc(Nc3ncc4scc(-c5cccc(N6CCCS6(=O)=O)c5)c4n3)cc2)CC1 CHEMBL4867910 IC50 33.0 nM
O=C1Cc2cc(Nc3ncc(C(F)(F)F)c(NCc4ccccc4)n3)ccc2N1 CHEMBL471520 IC50 34.0 nM
COc1ccc(Nc2ncc(C(C)C)c(Oc3cccc4c3C(=O)CC4)n2)cc1 CHEMBL3657328 IC50 34.0 nM
C=CC(=O)NC(C)C(=O)N1CCN(c2ccc(Nc3ncc(C(F)(F)F)c(Nc4ccccc4C(=O)NC)n3)cc2)CC1 CHEMBL5071797 IC50 34.0 nM
CCOc1cc(N2CCN(C)CC2)ccc1Nc1ncc2cc(-c3cccc(NC(=O)c4cccc(C(F)(F)F)c4)c3)c(=O)n(C[C@H]3CCCO3)c2n1 CHEMBL5415503 Kd 34.0 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccccc3Cl)n2)cc1 CHEMBL4852217 IC50 34.37 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)nc2[nH]ccc12 CHEMBL4567448 IC50 34.5 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc(OC)c(Cl)c3)n2)cc1 CHEMBL4869158 IC50 34.74 nM
COc1cc(Nc2ncc3ccn(-c4cccc(CCC(=O)O)c4)c3n2)cc(OC)c1OC CHEMBL207605 IC50 35.0 nM
CNC(=O)c1ccccc1Nc1c(C(F)(F)F)cnc2[nH]c(-c3ccc(N4CCOCC4)cc3)cc12 CHEMBL2315565 Kd 35.0 nM
COc1ccc(Nc2ncc(C#N)c(Oc3cccc4c3C(=O)CC4)n2)cc1 CHEMBL3657346 IC50 35.0 nM
CN(c1ncccc1CNc1nc(Nc2cccc(C#N)c2)nc2[nH]cc(F)c12)S(C)(=O)=O CHEMBL4851114 IC50 35.0 nM
COc1cc(Nc2ncc3scc(-c4cccc(N(C)S(C)(=O)=O)c4)c3n2)cc(OC)c1OC CHEMBL4877120 IC50 35.0 nM
C=CC(=O)N[C@H](C)C(=O)N1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC)n3)cc2)CC1 CHEMBL5078868 IC50 35.0 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3ccc(Cl)cc3)n2)cc1 CHEMBL4879100 IC50 35.33 nM
CNC(=O)Cc1cccc(Oc2nc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)ncc2C(F)(F)F)c1 CHEMBL3665890 IC50 36.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2ccc(CC(=O)N(C)C)cc2)n1 CHEMBL3665894 IC50 36.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(OCc2cccc(OC)c2OC)n1 CHEMBL3665923 IC50 36.0 nM
CN1Cc2cccc(Oc3nc(Nc4ccc(OC5CCOCC5)cc4)ncc3C(F)(F)F)c2C1=O CHEMBL3657339 IC50 36.0 nM
CCN1CCN(c2ccc(Nc3ncc4scc(-c5cccc(C(=O)NC)c5)c4n3)cc2)CC1 CHEMBL4861021 IC50 36.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1nc(-n2cnc3ccccc32)c2cc[nH]c2n1 CHEMBL5172526 IC50 36.76 nM
COc1cc(Nc2ncc3ccn(-c4cccc(CC(=O)O)c4)c3n2)cc(OC)c1OC CHEMBL206255 IC50 37.0 nM
CNC(=O)c1ccccc1Nc1c(C#N)cnc2[nH]c(-c3ccc(F)cc3)cc12 CHEMBL2315564 IC50 37.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCOCCOCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2OC)ncc1Cl CHEMBL5183401 IC50 37.3 nM
COc1cc(Nc2ncc3ccn(-c4cccc(C(=O)NCCN(C)C)c4)c3n2)cc(OC)c1OC CHEMBL379837 IC50 38.0 nM
COc1cc(Nc2ncc3ccn(-c4cccc(C(=O)O)c4)c3n2)cc(OC)c1OC CHEMBL207131 IC50 38.0 nM
O=C1CCc2cc(Nc3ncc(C(F)(F)F)c(NCc4ccccn4)n3)ccc2N1 CHEMBL520059 IC50 38.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2ccc3[nH]cnc3c2)n1 CHEMBL3665887 IC50 38.0 nM
CCN(c1ccccc1Oc1nc(Nc2cc(F)c(C(=O)NC3CCN(C)CC3)cc2OC)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL3665939 IC50 38.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(OC(C)C(=O)N3CCOCC3)cc2)ncc1Cl CHEMBL4444509 IC50 38.0 nM
COc1cc2c(cc1Nc1ncc3c(n1)N(C)c1sc(C)nc1C(=O)N3C)CN(C)CC2 CHEMBL4763555 IC50 38.0 nM
CN(c1ncccc1CNc1nc(Nc2ccc(F)cc2)nc2[nH]cc(F)c12)S(C)(=O)=O CHEMBL4879310 IC50 38.0 nM
CC(C)Nc1cc(F)cc(-c2n[nH]c3ncc(-c4cccc(S(C)(=O)=O)c4)cc23)c1 CHEMBL5407680 IC50 38.0 nM
CP(C)(=O)c1ccccc1Nc1nc(Nc2ccc(C(=O)N3CCNCC3)cc2)nc2[nH]ccc12 CHEMBL4589102 IC50 38.2 nM
COc1cc(C(=O)NC2CCNCC2)c(F)cc1Nc1ncc2scc(-c3ccccc3OC)c2n1 CHEMBL4789212 IC50 38.2 nM
CCNS(=O)(=O)c1ccc(Nc2nc(Nc3ccccc3P(C)(C)=O)c3cc[nH]c3n2)cc1 CHEMBL4475504 IC50 38.7 nM
COc1ccccc1-c1csc2cnc(Nc3ccc(C(=O)NC4CCNCC4)cc3)nc12 CHEMBL4784230 IC50 38.8 nM
COc1ccc(-c2ccc3cnc(Nc4ccc(C5CCN(CC(N)=O)CC5)cc4)nn23)cn1 CHEMBL1934338 IC50 39.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2ccc(CC(N)=O)cc2)n1 CHEMBL3665892 IC50 39.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(OCCN2CCCC2=O)n1 CHEMBL3665918 IC50 39.0 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc(OC)c(F)c3)n2)cc1 CHEMBL4848228 IC50 39.07 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3ccc(Br)cc3)n2)cc1 CHEMBL4864144 IC50 39.66 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1nc2c(NCc3cccnc3N(C)S(C)(=O)=O)cccn2n1 CHEMBL3642360 IC50 39.71 nM
COc1cc2c(cc1Nc1nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN(C)C)CC2 CHEMBL461876 pKi 39.81 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)c1 CHEMBL1967116 pKi 39.81 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(C)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1984162 pKi 39.81 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(OCC2CCCCO2)n1 CHEMBL3665924 IC50 40.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc(CC(=O)N(C)C)c2)n1 CHEMBL3665891 IC50 41.0 nM
CN(c1ncccc1CNc1nc(Nc2ccc(F)c(Cl)c2)nc2[nH]cc(F)c12)S(C)(=O)=O CHEMBL4857778 IC50 41.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1nc(Oc2cccc3c2C(=O)CC3)c2sccc2n1 CHEMBL5201748 IC50 41.38 nM
CN1CCN(c2ccc(Nc3nc4c(CCc5ccccc5N(C)S(C)(=O)=O)cccn4n3)cc2)CC1 CHEMBL3642415 IC50 41.73 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 Kd 42.0 nM
COc1ccccc1Nc1nc(Nc2ccc3c(c2OC)CCCC(N2CCN(CCO)CC2)C3)ncc1Cl CHEMBL3943066 IC50 42.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3[nH]ccc23)n1 CHEMBL3665885 IC50 43.0 nM
CN(c1ncccc1CNc1c(C#N)cnc2[nH]c(-c3ccccc3)cc12)S(C)(=O)=O CHEMBL2315579 Kd 44.0 nM
COc1cc(N2CCNCC2)ccc1Nc1ncc2c(n1)N(C)c1sc(C)nc1C(=O)N2C CHEMBL4791659 IC50 44.0 nM
CNC(=O)c1ccc(Nc2ncc3c(n2)N(C)c2sc(C)nc2C(=O)N3C)c(OC)c1 CHEMBL4762549 IC50 45.0 nM
O=C1Cc2cc(Nc3ncc(Br)c(NCc4ccccn4)n3)ccc2N1 CHEMBL470316 IC50 46.0 nM
CCN1CCCC(c2ccc(Nc3ncc(C(F)(F)F)c(CCc4ncccc4CC(N)=O)n3)cc2)C1 CHEMBL3692205 IC50 46.0 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1ncc2c(n1)N(C)c1sc(C)nc1C(=O)N2C CHEMBL4747113 IC50 46.0 nM
Cc1nc2c(s1)N(C)c1nc(Nc3ccc(N4CCN(C)CC4)cc3OCCO)ncc1N(C)C2=O CHEMBL4760231 IC50 46.5 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc(C(C)=O)c2)n1 CHEMBL3665873 IC50 47.0 nM
COc1ccc(C#N)c(Oc2nc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)ncc2C(F)(F)F)c1 CHEMBL3665906 IC50 47.0 nM
CCCN1c2nc(Nc3ccc(N4CCC(N5CCN(C)CC5)CC4)cc3OC)ncc2N(C)C(=O)c2nc(C)sc21 CHEMBL4748282 IC50 47.0 nM
COc1cc(N2CCN(S(C)(=O)=O)CC2)ccc1Nc1ncc2c(n1)N(C)c1sc(C)nc1C(=O)N2C CHEMBL4756535 IC50 47.0 nM
COc1ccccc1-c1csc2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)c(F)c3)nc12 CHEMBL4797358 IC50 47.8 nM
CN(c1cccc(-c2ccc3cnc(Nc4ccc(C5CCN(CC(N)=O)CC5)cc4)nn23)c1)S(C)(=O)=O CHEMBL1934340 IC50 48.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2ccccc2)n1 CHEMBL3665868 IC50 48.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCCCCCC(=O)Nc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2OC)ncc1Cl CHEMBL5183755 IC50 48.0 nM
CN1Cc2ccc(Nc3nc4c(NCc5cccnc5N(C)S(C)(=O)=O)cccn4n3)cc2C1 CHEMBL3642387 IC50 48.13 nM
COc1ccccc1-c1csc2cnc(Nc3ccc(C(=O)NC4CCNCC4)cc3F)nc12 CHEMBL4797411 IC50 48.3 nM
CNC(=O)Cc1ccc(Oc2nc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)ncc2C(F)(F)F)cc1 CHEMBL3665893 IC50 49.0 nM
COc1cc(Nc2ncc3scc(-c4cccc(C(=O)O)c4)c3n2)cc(OC)c1OC CHEMBL4876873 IC50 49.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(C(=S)SCCCCCCCC(=O)Nc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2OC)ncc1Cl CHEMBL5184768 IC50 49.5 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCCCCCCC(=O)Nc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2OC)ncc1Cl CHEMBL5177296 IC50 49.8 nM
C=COC(=O)NCc1ccc(Nc2nc(Nc3ccccc3C(=O)NC)n3ccnc3n2)cc1 CHEMBL3393280 IC50 50.0 nM
CNC(=O)c1ccccc1Nc1c(C(F)(F)F)cnc2[nH]c(-c3ccc(F)cc3)cc12 CHEMBL2315562 IC50 51.0 nM
CCc1cc(C(=O)N(C)C)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657294 IC50 51.0 nM
COc1cc(N2CCOCC2)ccc1Nc1nc(Nc2ccccc2P(C)(C)=O)c2cc[nH]c2n1 CHEMBL4456459 IC50 51.1 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2ccccc2C(N)=O)n1 CHEMBL3665870 IC50 52.0 nM
COc1cc(C2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C)c1sc(C)nc1C(=O)N2C CHEMBL4763952 IC50 52.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCCCCCCCCC(=O)NCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2OC)ncc1Cl CHEMBL5183462 IC50 52.5 nM
COc1cc(C(=O)OCc2ccccc2)c(Cl)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N(C)C3)n1 CHEMBL3657326 IC50 53.0 nM
COc1cc(Nc2ncc3ccn(-c4cccc(C(=O)NCCCN(C)C)c4)c3n2)cc(OC)c1OC CHEMBL207961 IC50 54.0 nM
CCN1CCN(c2ccc(Nc3ncc4scc(-c5ccc6cc[nH]c6c5)c4n3)cc2)CC1 CHEMBL4876098 IC50 54.0 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(/C=C/c3ccccc3)n2)n[nH]1 CHEMBL482968 IC50 55.0 nM
COc1ccccc1-c1ccc2cnc(Nc3ccc(C4CCN(CC(N)=O)CC4)cc3)nn12 CHEMBL1934335 IC50 55.0 nM
CCOc1cc(N2CCN(C)CC2)ccc1Nc1ncc2c(n1)N(C)c1sc(C)nc1C(=O)N2C CHEMBL4741192 IC50 55.0 nM
CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)nc2[nH]ccc12)S(C)(=O)=O CHEMBL4873346 IC50 55.0 nM
CNC(=O)c1ccccc1-c1csc2cnc(Nc3cc(OC)c(OC)c(OC)c3)nc12 CHEMBL4879263 IC50 55.0 nM
CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc(OC)cc3)n2)cc1 CHEMBL4867150 IC50 55.63 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(OCC2CCCCN2C)n1 CHEMBL3665920 IC50 56.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCCCCCCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2OC)ncc1Cl CHEMBL5201103 IC50 57.1 nM
COc1ccccc1-c1csc2cnc(Nc3ccc(NC(=O)C4CCNCC4)cc3)nc12 CHEMBL4780493 IC50 57.7 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2ccccc2C(C)=O)n1 CHEMBL3665898 IC50 58.0 nM
CS(=O)(=O)c1ccccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F CHEMBL488089 IC50 59.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc2c(n1)N(C)c1sc(C(C)C)nc1C(=O)N2C CHEMBL4759782 IC50 59.0 nM
CCN1CCN(c2ccc(Nc3ncc4scc(-c5cccc(C(=O)O)c5)c4n3)cc2)CC1 CHEMBL4873271 IC50 59.0 nM
CN(c1ncccc1CNc1cccn2nc(Nc3ccc(OCCN4CCCC4)cc3)nc12)S(C)(=O)=O CHEMBL3642347 IC50 59.73 nM
COc1ccc(Nc2ncc(F)c(Oc3cccc4c3C(=O)CC4)n2)c(OC)c1 CHEMBL3657315 IC50 60.0 nM
COC(=O)COc1nc(Nc2ccc(C(=O)NC3CCN(C)CC3)cc2OC)ncc1C(F)(F)F CHEMBL3665926 IC50 61.0 nM
CNC(=O)c1ccc(Oc2nc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)ncc2C(F)(F)F)cc1 CHEMBL3665896 IC50 62.0 nM
CP(C)(=O)c1ccccc1Nc1nc(Nc2ccc(C(=O)N3CCOCC3)cc2)nc2[nH]ccc12 CHEMBL4517847 IC50 62.1 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc2c(n1)N(C)c1sc(C)nc1C(=O)N2 CHEMBL4749164 IC50 62.2 nM
CN1CCN(c2ccc(Nc3nc4c(N(C)Cc5ccccc5N(C)S(C)(=O)=O)cccn4n3)cc2)CC1 CHEMBL3642406 IC50 62.53 nM
COc1cc(Nc2ncc3ccn(-c4cccc(CCC(=O)NCC(C)C)c4)c3n2)cc(OC)c1OC CHEMBL207499 IC50 63.0 nM
COc1cc(Nc2ncc3ccn(-c4cccc(CC#N)c4)c3n2)cc(OC)c1OC CHEMBL382354 IC50 63.0 nM
CC(Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL1825138 pKi 63.1 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)O)c5)cnc(N)c34)cc2)c1 CHEMBL1989708 pKi 63.1 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4ccc(OC(F)F)cc4)cc3)c12 CHEMBL1972220 pKi 63.1 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1979690 pKi 63.1 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccnc2)n1 CHEMBL3665874 IC50 64.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc(Cl)c2)n1 CHEMBL3665879 IC50 64.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Sc2ccccc2)n1 CHEMBL3665912 IC50 64.0 nM
Cc1c[nH]c2nc(Nc3ccc4c(c3)CC(=O)N4)nc(NCc3cccnc3N(C)S(C)(=O)=O)c12 CHEMBL4846896 IC50 64.0 nM
CP(C)(=O)c1ccccc1Nc1nc(Nc2cnn(C3CCOCC3)c2)nc2[nH]ccc12 CHEMBL4471190 IC50 64.1 nM
CP(C)(=O)c1ccccc1Nc1nc(Nc2ccc(C(=O)N[C@@H]3CCCNC3)cc2)nc2[nH]ccc12 CHEMBL4581127 IC50 64.4 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2ccc(C(=O)N(C)C)cc2)n1 CHEMBL3665897 IC50 65.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(CC(=O)OCC(C)COc3no[n+]([O-])c3S(=O)(=O)c3ccccc3)cc2)ncc1Cl CHEMBL5422197 IC50 66.04 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc(C(=O)N(C)C)c2)n1 CHEMBL3665889 IC50 67.0 nM
COc1cc(N2CCN(CCN(C)C)CC2)ccc1Nc1ncc2c(n1)N(C)c1sc(C)nc1C(=O)N2C CHEMBL4799569 IC50 67.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc2c(n1)N(CC(F)(F)F)c1sc(C)nc1C(=O)N2C CHEMBL4796049 IC50 68.0 nM
CS(=O)(=O)Nc1cccc(-c2csc3cnc(Nc4ccc(N5CCCCC5)cc4)nc23)c1 CHEMBL4874015 IC50 68.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2CC(=O)N3)n1 CHEMBL3665908 IC50 69.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(C(=S)SCCCCCCCCCC(=O)Nc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2OC)ncc1Cl CHEMBL5203801 IC50 69.5 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Sc2ccccc2)n1 CHEMBL3665913 IC50 70.0 nM
CN1CCN(c2cccc(Nc3nc4c(NCc5cccnc5N(C)S(C)(=O)=O)cccn4n3)c2)CC1 CHEMBL3642359 IC50 71.08 nM
COc1ccccc1-c1csc2cnc(Nc3ccc(C(=O)N[C@@H]4CCNC4)c(F)c3)nc12 CHEMBL4799949 IC50 71.3 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCCCCCCCC(=O)Nc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2OC)ncc1Cl CHEMBL5186599 IC50 71.8 nM
CC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(N[C@@H]4CCC[C@H]4N(C)C)n3)ccc12 CHEMBL455680 IC50 72.0 nM
COc1cc(F)ccc1Nc1ncc(F)c(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657350 IC50 72.0 nM
COc1cc(Nc2ncc3ccn(-c4cccc(C(=O)NCCN5CCCC5)c4)c3n2)cc(OC)c1OC CHEMBL377708 IC50 73.0 nM
CNC(=O)c1cccc(Oc2nc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)ncc2C(F)(F)F)c1 CHEMBL3665888 IC50 74.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(OC2CCCN(C)C2)n1 CHEMBL3665921 IC50 74.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncnc(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL3545360 Kd apparent 74.0 nM
COc1cc(N2CCN(CCO)CC2)ccc1Nc1ncc2c(n1)N(C)c1sc(C)nc1C(=O)N2C CHEMBL4765182 IC50 74.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1nccc(Oc2cccc3c2C(=O)CC3)n1 CHEMBL3657313 IC50 75.0 nM
O=C(NC1CC1)c1ccccc1Nc1nc(Nc2ccc(OCC(=O)N3CCOCC3)cc2)ncc1Cl CHEMBL4452825 IC50 75.8 nM
COc1cccc(Nc2nc(NCc3cccnc3N(C)S(C)(=O)=O)c3c(F)c[nH]c3n2)c1C CHEMBL4874863 IC50 76.0 nM
O=C1Cc2cc(Nc3ncc(Cl)c(NCc4ccccn4)n3)ccc2N1 CHEMBL511152 IC50 77.0 nM
CCc1ccc(-c2ccc3c(c2)-c2c(cnn2C)S(=O)(=O)N3C)cc1 CHEMBL2333435 IC50 77.0 nM
C=CC(=O)NCCC(=O)N1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC)n3)cc2)CC1 CHEMBL5089009 IC50 77.0 nM
CN1CCC(c2ccc(Nc3nc4c(NCc5cccnc5N(C)S(C)(=O)=O)cccn4n3)cc2)CC1 CHEMBL3642346 IC50 77.33 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2ccccc2CC(N)=O)n1 CHEMBL3665881 IC50 78.0 nM
COc1cc(C(=O)N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc2c(n1)N(C)c1sc(C)nc1C(=O)N2C CHEMBL4758463 IC50 78.0 nM
COc1cc(Nc2ncc3scc(-c4ccccc4NS(C)(=O)=O)c3n2)cc(OC)c1OC CHEMBL4869934 IC50 78.0 nM
CNC(=O)c1ccc(Nc2ncc3scc(-c4ccccc4OC)c3n2)cc1 CHEMBL4791977 IC50 79.3 nM
CCN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1967998 pKi 79.43 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1998585 pKi 79.43 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(OC(F)F)cc5)cc4)csc23)cn1 CHEMBL1988387 pKi 79.43 nM
CNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCNCC4)cc3)n2)s1 CHEMBL1999484 pKi 79.43 nM
CC(C)Oc1cc(C(=O)NC2CCNCC2)ccc1Nc1nc(Nc2ccccc2P(C)(C)=O)c2cc[nH]c2n1 CHEMBL4590854 IC50 80.8 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2ccccc2-c2cc[nH]n2)n1 CHEMBL3665900 IC50 81.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2ccccc2CC(=O)N(C)C)n1 CHEMBL3665883 IC50 82.0 nM
COP(=O)(Cc1ccc(Nc2nc(Nc3ccccc3P(C)(C)=O)c3cc[nH]c3n2)cc1)OC CHEMBL4592919 IC50 82.0 nM
COc1cc(N2CCN(C)CC2=O)ccc1Nc1ncc2c(n1)N(C)c1sc(C)nc1C(=O)N2C CHEMBL4754414 IC50 82.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(NS(=O)(=O)c3ccc(C)cc3)cc2)ncc1Cl CHEMBL4085413 IC50 82.5 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCN(CCCCCCCCCC(=O)Nc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2OC)ncc1Cl CHEMBL5207575 IC50 82.7 nM
CC(=O)Nc1cc(F)cc(-c2n[nH]c3ncc(-c4cccc(S(C)(=O)=O)c4)cc23)c1 CHEMBL5427137 IC50 83.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(NS(=O)(=O)c3ccc(C)cc3)c(C)c2)ncc1Cl CHEMBL4063835 IC50 84.6 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(NS(=O)(=O)c3ccc(F)cc3)c(OC)c2)ncc1Cl CHEMBL4075181 IC50 84.7 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2ccccc2Cl)n1 CHEMBL3665880 IC50 85.0 nM
CC(=O)Nc1ccc(Nc2nc(Nc3ccccc3P(C)(C)=O)c3cc[nH]c3n2)cc1 CHEMBL4549746 IC50 85.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(NS(=O)(=O)c3ccc(F)cc3)cc2)ncc1Cl CHEMBL4088025 IC50 86.7 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2CCC3C)n1 CHEMBL3665866 IC50 88.0 nM
COc1cc(C(=O)NC2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Oc2ccc(CC(=O)O)cc2)n1 CHEMBL3665878 IC50 89.0 nM
CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 CHEMBL4281823 IC50 89.0 nM
C=CC(=O)NCC(=O)N1CCN(c2ccc(Nc3ncc(C(F)(F)F)c(Nc4ccccc4C(=O)NC)n3)cc2)CC1 CHEMBL5074752 IC50 90.0 nM
CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]c(F)c(c3c2)-c2cn(nc2C(F)(F)F)CCCC1=O CHEMBL5086263 IC50 90.0 nM
COc1cc(Nc2ncc3scc(-c4cccc(S(C)(=O)=O)c4)c3n2)cc(OC)c1OC CHEMBL4874892 IC50 91.0 nM
CNC(=O)c1ccc(Nc2nc(Nc3ccccc3C(=O)NC)c3cc[nH]c3n2)cc1 CHEMBL4445212 IC50 91.8 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(Cl)c(Oc2cccc3c2C(=O)N[C@@H](C)CO3)n1 CHEMBL3661421 IC50 92.0 nM
COc1cc(Nc2ncc3ccn(-c4cccc(CCC#N)c4)c3n2)cc(OC)c1OC CHEMBL206524 IC50 93.0 nM
Cc1cc(N2CCN(CCC#N)CC2)cc2nc(-c3c(NC[C@@H](O)c4ccccc4Cl)cc[nH]c3=O)[nH]c12 CHEMBL564417 IC50 94.0 nM
CS(=O)(=O)c1ccccc1CNc1cccn2nc(Nc3ccc(OCCN4CCCC4)cc3)nc12 CHEMBL3642364 IC50 98.78 nM
COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(C(F)(F)F)c(Oc2cccc3c2CCC3C)n1 CHEMBL3665867 IC50 99.0 nM
CN1CCN(c2ccc(Nc3nc(Oc4cccc5c4C(=O)CC5)c4cc[nH]c4n3)c(C(F)(F)F)c2)CC1 CHEMBL5178966 IC50 99.75 nM