Cc1ccc(NC(=O)c2cc(C(F)(F)F)ccn2)cc1-c1cc(OCC(O)CP(=O)(O)O)nc(N2CCOCC2)c1 CHEMBL3924812 IC50 0.024 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cnc(OCCOP(=O)(O)O)c(N2CCOCC2)c1 CHEMBL3961999 IC50 0.03 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1nc(N2CCOCC2)c2sccc2n1 CHEMBL3933272 IC50 0.039 nM
Cc1ccc(NC(=O)c2cccc(C(F)F)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3951474 IC50 0.056 nM
Cc1cc(F)c(C(=O)NCCCC(C)(C)C)cc1-c1ccc2c(=O)n(C)ncc2c1 CHEMBL4776565 Ki 0.06 nM
CNc1cc(-c2cccnc2Nc2cc(NC(=O)NCCC(C)(C)C)c(F)cc2C)ncn1 CHEMBL5094514 Ki 0.06 nM
Cc1cc(F)c(NC(=O)NCCC(C)(C)C)cc1Nc1ccc2ncn(C)c(=O)c2c1F CHEMBL4780060 Ki 0.061 nM
CNc1ncc2cc(-c3cc(NC(=O)NCCC(C)(C)C)c(F)cc3C)c(C)nc2n1 CHEMBL3577124 Ki 0.061 nM
Cc1cc(F)c(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1-c1cnc2c(=O)n(C)ncc2c1 CHEMBL4778419 Ki 0.062 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cn2ccnc2c(N2CCOCC2)n1 CHEMBL3905257 IC50 0.065 nM
CNc1ncc2cc(-c3cc(NC(=O)NCCC(C)(C)C)c(F)cc3C)c(=O)n(C)c2n1 CHEMBL4740241 Ki 0.081 nM
C=C(C)c1cc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)nc(N2CCOCC2)n1 CHEMBL3959581 IC50 0.09 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(F)F)c2)cc1-c1cc(OCCOP(=O)(O)O)nc(N2CCOC[C@H]2C)c1 CHEMBL3952506 IC50 0.1 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(OCCOP(=O)(O)O)nc(N2CCOCC2)c1 CHEMBL3929689 IC50 0.1 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)ncn1 CHEMBL3956654 IC50 0.1 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3967893 IC50 0.103 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(CC#N)c1 CHEMBL3966766 IC50 0.103 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(S(C)(=O)=O)n1 CHEMBL3972141 IC50 0.11 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N)nc(N2CCOCC2)c1 CHEMBL3919205 IC50 0.117 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cnc(OC2CCOCC2)c(N2CCOCC2)c1 CHEMBL3962812 IC50 0.119 nM
Cc1ccc(NC(=O)c2cccc(C(C)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3914464 IC50 0.122 nM
Cc1ccc(NC(=O)c2cccc(S(C)(=O)=O)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3907015 IC50 0.124 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)c1 CHEMBL3942721 IC50 0.13 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(OCCO)n1 CHEMBL3987177 IC50 0.132 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(-n2ccnc2)n1 CHEMBL3928030 IC50 0.134 nM
Cc1ccc(NC(=O)c2cncc(N(C)C)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3976881 IC50 0.137 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2=O)nc(N2CCOCC2)n1 CHEMBL3984282 IC50 0.148 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc2nccn2c(N2CCOCC2)n1 CHEMBL3927963 IC50 0.155 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cncc(N2CCOCC2)n1 CHEMBL3889721 IC50 0.156 nM
Cc1ncc(NC(=O)c2cccc(C(F)F)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3960515 IC50 0.16 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3909119 IC50 0.16 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3912148 IC50 0.161 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc2[nH]cnc2c(N2CCOCC2)n1 CHEMBL3924576 IC50 0.171 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3945935 IC50 0.172 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1nc(N2CCOCC2)nc(N2CCOCC2)c1C CHEMBL3903274 IC50 0.179 nM
CCn1cc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)nc(N2CCOCC2)c1=O CHEMBL3930929 IC50 0.18 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3928581 IC50 0.182 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cn2ccnc2c(N2CCOC[C@H]2C)n1 CHEMBL4108504 IC50 0.185 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)c1 CHEMBL3960436 IC50 0.187 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1c[nH]c(=O)c(N2CCOCC2)n1 CHEMBL3971301 IC50 0.187 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(OC2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3906652 IC50 0.191 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cnc(O[C@H](C)C#N)c(N2CCOCC2)c1 CHEMBL4111816 IC50 0.196 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(-n2cc(C(C)(C)O)nn2)n1 CHEMBL3966243 IC50 0.198 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1ccnc(N2CCO[C@H](CO)C2)c1 CHEMBL3980394 IC50 0.199 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(OCCO)nc(N2CCOCC2)c1 CHEMBL4583691 IC50 0.2 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(NCCO)n1 CHEMBL3955743 IC50 0.2 nM
Cc1ccc(NC(=O)c2cccc(OC(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3960775 IC50 0.202 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c2nccn2n1 CHEMBL3936964 IC50 0.205 nM
Cc1ccc(NC(=O)c2cccc(C(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3894542 IC50 0.213 nM
CCNc1nc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)cc(N2CCOCC2)n1 CHEMBL3946003 IC50 0.214 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)n(C)c(=O)c1 CHEMBL3918750 IC50 0.215 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1c[nH]c(=O)c(N2CCOCC2)c1 CHEMBL3924392 IC50 0.219 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c2oc(=O)[nH]c2c1 CHEMBL3947696 IC50 0.225 nM
Cc1ccc(NC(=O)c2cncc(N(C)C)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3904667 IC50 0.23 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 CHEMBL3940726 IC50 0.245 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCCOCC2)nc(N2CCOCC2)n1 CHEMBL3959652 IC50 0.25 nM
Cc1ccc(NC(=O)c2ccnc(S(C)(=O)=O)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3949277 IC50 0.25 nM
Cc1ncc(NC(=O)c2cccc(C(C)(F)F)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3951813 IC50 0.253 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 CHEMBL3927672 IC50 0.255 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cn(CC(F)F)c(=O)c(N2CCOCC2)n1 CHEMBL3946071 IC50 0.263 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3936445 IC50 0.265 nM
Cc1ccc(NC(=O)c2cccc(S(C)(=O)=O)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3923479 IC50 0.269 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cn(C)c(=O)c(N2CCOCC2)n1 CHEMBL3945337 IC50 0.27 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n([C@@H](C)C#N)c1 CHEMBL3935549 IC50 0.273 nM
Cc1ccc(NC(=O)c2cccc(C(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 CHEMBL3951205 IC50 0.278 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CC3CCC(C2)O3)nc(N2CCOCC2)n1 CHEMBL3955103 IC50 0.282 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1-c1cc(C2CCOCC2)nc(N2CCOCC2)c1 CHEMBL3933060 IC50 0.285 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n([C@H](C)C#N)c1 CHEMBL4112070 IC50 0.285 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(N2CCO[C@H](CO)C2)c1 CHEMBL3971254 IC50 0.29 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3968350 IC50 0.299 nM
COc1ncc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)cc1N1CCOCC1 CHEMBL3956383 IC50 0.299 nM
Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1Nc1ncccc1-c1ncnc2[nH]cnc12 CHEMBL1197798 Ki 0.3 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4ccccc4[nH]3)ccnc2N1 CHEMBL3955401 IC50 0.3 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cnc(O[C@H]2CCOC[C@H]2F)c(N2CCOCC2)c1 CHEMBL4437227 IC50 0.3 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(OCCO)n1 CHEMBL3900045 IC50 0.304 nM
COc1ncc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)cnc2C)cc1N1CCOCC1 CHEMBL3978705 IC50 0.31 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(C(F)(F)F)nc(N2CCOCC2)n1 CHEMBL3896594 IC50 0.314 nM
CNc1nc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)cc(N2CCOCC2)n1 CHEMBL3969555 IC50 0.322 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(NC(CO)CO)n1 CHEMBL3963090 IC50 0.322 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C(C)C)c1 CHEMBL3913790 IC50 0.322 nM
Cc1ccc(NC(=O)c2cc(C(C)(C)C)no2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3975759 IC50 0.328 nM
O=C(Nc1cccc(C(F)(F)F)c1)c1ccc(CF)c(-c2ccnc(N3CCOCC3)c2)c1 CHEMBL3919411 IC50 0.332 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(CCO)c1 CHEMBL3931694 IC50 0.341 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N)n1 CHEMBL3894913 IC50 0.344 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOC[C@H]2CO)nc(N2CCOCC2)n1 CHEMBL4110542 IC50 0.347 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc(-c4ccncc4)c[nH]3)ccnc2N1 CHEMBL3941872 IC50 0.35 nM
Cc1ccc(NC(=O)c2cc(C(C)(C)C)on2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3932011 IC50 0.352 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3953527 IC50 0.353 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CC3(COC3)C2)nc(N2CCOCC2)n1 CHEMBL3894928 IC50 0.356 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc(C2CCOCC2)nc(N2CCOCC2)c1 CHEMBL3940053 IC50 0.359 nM
CCn1cc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)cc(N2CCOCC2)c1=O CHEMBL3890463 IC50 0.361 nM
CCN1CCN(c2cc(C(=O)Nc3ccc(C)c(-c4ccnc(N5CCOCC5)c4)c3)cc(C(F)(F)F)c2)CC1 CHEMBL3946717 IC50 0.362 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(C2CCOCC2)nc(N2CCOCC2)c1 CHEMBL3964430 IC50 0.363 nM
CCOc1ncc(-c2cc(NC(=O)c3ccnc(C(F)(F)F)c3)ccc2C)cc1N1CCOCC1 CHEMBL3917649 IC50 0.366 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2C3CCC2COC3)nc(N2CCOCC2)n1 CHEMBL3903859 IC50 0.376 nM
C=C(C)c1cc(N2CCOCC2)nc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)n1 CHEMBL3982146 IC50 0.376 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3916539 IC50 0.386 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCS(=O)(=O)CC2)n1 CHEMBL3969121 IC50 0.389 nM
CCOc1ncc(-c2cc(NC(=O)c3ccnc(C(C)(C)C#N)c3)ccc2C)cc1N1CCOCC1 CHEMBL3890682 IC50 0.393 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3934972 IC50 0.396 nM
Cc1ccc(NC(=O)c2cc(C(F)(F)F)cc(S(C)(=O)=O)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3975494 IC50 0.398 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4cc5c(cc4[nH]3)CCC5)ccnc2N1 CHEMBL3896243 IC50 0.4 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(OC2CCOCC2)nn1 CHEMBL4461296 IC50 0.4 nM
[2H]C1(Oc2ncc(-c3cc(NC(=O)c4cccc(C(F)(F)F)c4)cnc3C)cc2N2CCOCC2)CCOCC1 CHEMBL4556909 IC50 0.4 nM
COc1cc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)nc(N2CCOCC2)c1 CHEMBL3926287 IC50 0.403 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)ccn1 CHEMBL3910602 IC50 0.403 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCS(=O)(=O)CC2)nc(N2CCOCC2)n1 CHEMBL3974358 IC50 0.408 nM
CCOc1ncc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)cc1N1CCOCC1 CHEMBL3910380 IC50 0.415 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 CHEMBL3938679 IC50 0.416 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CC3(COC3)C2)n1 CHEMBL3947016 IC50 0.421 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2=O)nc(N2CCOCC2)n1 CHEMBL3889893 IC50 0.431 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)cnn1 CHEMBL3897780 IC50 0.432 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOC(C)(C)C2)nc(N2CCOCC2)n1 CHEMBL3966257 IC50 0.433 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3982101 IC50 0.436 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cnc(N2CCOCC2)s1 CHEMBL3942386 IC50 0.455 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCCC2=O)n1 CHEMBL3903846 IC50 0.456 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cnc(OC2CCOCC2)c(N2CCOCC2)c1 CHEMBL3893855 IC50 0.457 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(-c2cnn(C)c2)nc(N2CCOCC2)c1 CHEMBL3905047 IC50 0.465 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cnc(OC(C)C)c(N2CCOCC2)c1 CHEMBL3902816 IC50 0.471 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1nc(N2CCOCC2)cc(N2CCOCC2)n1 CHEMBL3970191 IC50 0.474 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cnc(O[C@@H](C)C#N)c(N2CCOCC2)c1 CHEMBL3900202 IC50 0.474 nM
Cc1ccc(NC(=O)c2ccnc(S(C)(=O)=O)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3959933 IC50 0.479 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3981117 IC50 0.483 nM
CCn1cc(C(=O)Nc2ccc(C)c(-c3ccnc(N4CCOCC4)c3)c2)cc(C(F)(F)F)c1=O CHEMBL3903630 IC50 0.489 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3911091 IC50 0.491 nM
COc1ccc(C(=O)Nc2cnc(C)c(-c3cc(N4CCOCC4)c(=O)n(C)c3)c2)cc1C(F)(F)F CHEMBL3937040 IC50 0.493 nM
NC(=O)c1cccc(Nc2nccc(-c3[nH]c(C4CC4)nc3-c3cccc(NC(=O)Cc4ccc(Cl)cc4)c3)n2)c1 CHEMBL254966 IC50 0.5 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)c1 CHEMBL3913923 IC50 0.5 nM
Cc1ccc(C(=O)Nc2cccc(C(C)(C)C)c2)cc1-c1cc(N2CCOCC2)ncn1 CHEMBL4081025 IC50 0.5 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cnc(OCCO)c(N2CCOCC2)c1 CHEMBL3984244 IC50 0.5 nM
Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C1(c2ncnc3[nH]cnc23)CC1 CHEMBL4466555 IC50 0.5 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cnc(OC(C)C)c(N2CCOCC2)c1 CHEMBL3941778 IC50 0.503 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCC(O)C2)n1 CHEMBL3896660 IC50 0.51 nM
Cc1ccc(NC(=O)c2csc(C(F)(F)F)n2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3958636 IC50 0.514 nM
Cc1ccc(NC(=O)c2cc(CN(C)C)cc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3952075 IC50 0.516 nM
Cc1ncc(NC(=O)c2ccnc(C(C)(F)F)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3983865 IC50 0.522 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3920039 IC50 0.527 nM
OCCn1cc(-c2ccc3c(c2)CC/C3=N\O)c(-c2ccncc2)n1 CHEMBL525191 Ki 0.54 nM
Cc1cc2[nH]c(C3[C@H]4c5cc(Oc6ccnc7c6CCC(=O)N7)ccc5O[C@@H]34)nc2cc1F CHEMBL4112452 IC50 0.54 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3982235 IC50 0.542 nM
Cc1ncc(NC(=O)c2cc(C(F)(F)F)cc(S(C)(=O)=O)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3891700 IC50 0.547 nM
Cc1ccc(NC(=O)c2cncc(C(C)(C)C)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3924379 IC50 0.562 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(CCS(C)(=O)=O)c1 CHEMBL3945747 IC50 0.562 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1c[nH]c(=O)c(N2CCOCC2)n1 CHEMBL3960378 IC50 0.599 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc(C(F)(F)F)c[nH]3)ccnc2N1 CHEMBL3932596 IC50 0.6 nM
CCCS(=O)(=O)Nc1ccc(F)c(-n2cc(-c3cncnc3)c3nc(N(C)C4CCN(CC)CC4)ccc32)c1F CHEMBL4212692 IC50 0.6 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(NCCO)nc(N2CCOCC2)c1 CHEMBL4455996 IC50 0.6 nM
COc1ncc(N2CCOCC2)cc1-c1cc(NC(=O)c2cccc(C(F)(F)F)c2)ccc1C CHEMBL3922193 IC50 0.606 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1nc(N2CCOCC2)cc(N2CCOCC2)n1 CHEMBL3937081 IC50 0.616 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCO[C@@H](C)C2)nc(N2CCOCC2)n1 CHEMBL3973655 IC50 0.625 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(NS(C)(=O)=O)n1 CHEMBL3977938 IC50 0.634 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1nc(C(C)C)cc(N2CCOCC2)n1 CHEMBL3943351 IC50 0.637 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3938806 IC50 0.65 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCO[C@H](C)C2)nc(N2CCOCC2)n1 CHEMBL4112482 IC50 0.651 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3986273 IC50 0.652 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CC3CC2CO3)nc(N2CCOCC2)n1 CHEMBL3978883 IC50 0.661 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 CHEMBL3968234 IC50 0.665 nM
Cc1ccc(NC(=O)c2ccnc(C(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 CHEMBL3947882 IC50 0.678 nM
CNc1cc(C2(C(=O)Nc3cc(C(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)ccc3C)CC2)ncn1 CHEMBL4060057 IC50 0.7 nM
Cc1ncc(NC(=O)c2ccnc(C(C)(F)F)c2)cc1-c1cc(NCCO)nc(N2CCOCC2)c1 CHEMBL4590865 IC50 0.7 nM
Cc1ccc2nc(C3C4Oc5ccc(Oc6ccnc7c6CCC(=O)N7)cc5C43)[nH]c2c1 CHEMBL3898602 IC50 0.71 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3912517 IC50 0.711 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2=O)nc(N2CCOCC2)n1 CHEMBL3977439 IC50 0.713 nM
O=C(Nc1cccc(C(F)(F)F)c1)c1ccc(C(F)F)c(-c2ccnc(N3CCOCC3)c2)c1 CHEMBL3891340 IC50 0.719 nM
CCn1cc(C(=O)Nc2ccc(C)c(-c3cc(N4CCOCC4)c(=O)n(C)c3)c2)cc(C(F)(F)F)c1=O CHEMBL3920610 IC50 0.735 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N(C)C)nc(N2CCOCC2)c1 CHEMBL3972341 IC50 0.765 nM
O=C(Nc1cccc(C(F)(F)F)c1)c1ccc(CO)c(-c2ccnc(N3CCOCC3)c2)c1 CHEMBL3928316 IC50 0.778 nM
Cc1ccc(NC(=O)c2cccc(C3(C#N)CC3)c2Cl)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3951027 IC50 0.785 nM
Cc1ccc(NC(=O)c2ccnc(C(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3960706 IC50 0.785 nM
Cc1ccc(NC(=O)c2cc(C(F)F)cnn2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5081262 IC50 0.8 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)n(C)c(=O)c1 CHEMBL3929643 IC50 0.818 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2CCO CHEMBL5085016 IC50 0.83 nM
CCn1cc(-c2cc(NC(=O)c3ccnc(C(F)(F)F)c3)ccc2C)cc(N2CCOCC2)c1=O CHEMBL3955962 IC50 0.835 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)ccn1 CHEMBL3898852 IC50 0.847 nM
Cc1ccc(NC(=O)c2cc(CN(C)C)cc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3894561 IC50 0.853 nM
Cc1ccc(NC(=O)c2cccc(S(C)(=O)=O)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3946466 IC50 0.86 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(NCCO)nc(N2CCOCC2)c1 CHEMBL3896098 IC50 0.872 nM
COc1ncc(-c2cc(NC(=O)c3ccnc(C(C)(C)C#N)c3)ccc2C)cc1N1CCOCC1 CHEMBL3904596 IC50 0.873 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc2[nH]cnc2c(N2CCOC[C@H]2C)n1 CHEMBL4115500 IC50 0.873 nM
CCn1cc(-c2cc(NC(=O)c3ccnc(C(C)(C)C#N)c3)ccc2C)cc(N2CCOCC2)c1=O CHEMBL3942103 IC50 0.89 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc(-c4ccccc4Cl)c[nH]3)ccnc2N1 CHEMBL3945405 IC50 0.9 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cnc(O)c(N2CCOCC2)c1 CHEMBL4593446 IC50 0.9 nM
CCN1CCN(c2cc(C(=O)Nc3ccc(C)c(-c4cc(N5CCOCC5)nc(N5CCOCC5)n4)c3)cc(C(F)(F)F)c2)CC1 CHEMBL3929795 IC50 0.905 nM
COc1ccc(C(=O)Nc2cnc(C)c(-c3ccnc(N4CCOCC4)c3)c2)cc1C(F)(F)F CHEMBL3964522 IC50 0.998 nM
CNc1nccc(-c2[nH]c(C3CC3)nc2-c2cccc(NC(=O)Cc3ccc(Cl)cc3)c2)n1 CHEMBL403854 IC50 1.0 nM
O=C(Cc1ccc(Cl)cc1)Nc1cccc(-c2nc(C3CC3)[nH]c2-c2ccnc(NCCN3CCNC3=O)n2)c1 CHEMBL429498 IC50 1.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1336 IC50 1.0 nM
CNC(=O)c1cc(Oc2ccc3c(c2)nc(Nc2ccc(Br)cc2)n3C)ccn1 CHEMBL513600 IC50 1.0 nM
Cn1c(Nc2ccc(Br)cc2)nc2cc(Oc3ccnc(C(N)=O)c3)ccc21 CHEMBL470358 IC50 1.0 nM
CC(C)(C)c1cccc(Nc2nc3cc(Oc4ccnc(C(N)=O)c4)ccc3s2)c1 CHEMBL1778410 IC50 1.0 nM
CNC(=O)c1cc(Oc2ccc3sc(Nc4cccc(C(C)(C)C)c4)nc3c2)ccn1 CHEMBL1778403 IC50 1.0 nM
CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(C(C)C)cc4)nc3c2)ccn1 CHEMBL1778395 IC50 1.0 nM
CCc1ccc(Nc2nc3cc(Oc4ccnc(C(=O)NC)c4)ccc3o2)cc1 CHEMBL1778394 IC50 1.0 nM
CNC(=O)c1cc(Oc2ccc3oc(Nc4cccc(C(C)(C)C)c4)nc3c2)ccn1 CHEMBL1778291 IC50 1.0 nM
NC(=O)c1ccc2nc(C3C4Oc5ccc(Oc6ccnc7c6CCC(=O)N7)cc5C43)[nH]c2c1 CHEMBL3892591 IC50 1.0 nM
Cc1ncc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL4062317 IC50 1.0 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C2CCOCC2)c1 CHEMBL3917231 IC50 1.005 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)cnn1 CHEMBL3921105 IC50 1.007 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(C(C)C)nc(N2CCOCC2)n1 CHEMBL3971265 IC50 1.018 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cnnc(N2CCOCC2)c1 CHEMBL3925869 IC50 1.03 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(=O)cc(N2CCOCC2)[nH]1 CHEMBL3948871 IC50 1.062 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(CCS(C)(=O)=O)c1 CHEMBL3944515 IC50 1.095 nM
COC(=O)NC[C@@H]1CN(c2cc(-c3cc(NC(=O)c4cccc(C(F)(F)F)c4)cnc3C)ccn2)CCO1 CHEMBL4111858 IC50 1.099 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)cc2[nH]c(=O)oc12 CHEMBL3976967 IC50 1.099 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 CHEMBL3942212 IC50 1.1 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCS(=O)(=O)CC2)nc(N2CCOCC2)n1 CHEMBL3940522 IC50 1.114 nM
CN1CCN(CCNc2nccc(-c3c(-c4cccc(O)c4)nc4sccn34)n2)S1(=O)=O CHEMBL5087577 IC50 1.12 nM
CNc1ncc2cc(-c3cc(NC(=O)NCCC(C)(C)C)c(F)cc3C)cnc2n1 CHEMBL3577123 IC50 1.2 nM
O=C1CCc2c(Oc3ccc4c(c3)[C@H]3C(c5nc6ccc(C(F)(F)F)cc6[nH]5)[C@H]3O4)ccnc2N1 CHEMBL4111470 IC50 1.2 nM
CNC[C@@H]1CN(c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)ccn2)CCO1 CHEMBL4111455 IC50 1.218 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1csc(N2CCOCC2)n1 CHEMBL3951901 IC50 1.292 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CN(C)C2=O CHEMBL5082350 IC50 1.3 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CN(CCO)C2=O CHEMBL5082692 IC50 1.3 nM
CC(=O)NC[C@@H]1CN(c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)ccn2)CCO1 CHEMBL4113898 IC50 1.343 nM
Oc1cc(-c2nc(-c3ccccc3)[nH]c2-c2ccncc2)ccc1Cl CHEMBL373011 IC50 1.4 nM
N#Cc1c(Oc2ccc(F)c(NC(=O)Cc3cccc(C(F)(F)F)c3)c2)ccc2nc(NC(=O)C3CC3)sc12 CHEMBL3125890 IC50 1.4 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(C4)C3c3nc4ccccc4[nH]3)ccnc2N1 CHEMBL3895915 IC50 1.4 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4ccc(C(F)(F)F)cc4[nH]3)ccnc2N1 CHEMBL3901590 IC50 1.4 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc(N2CCOCC2)ncn1 CHEMBL3985343 IC50 1.416 nM
Cc1ncc(NC(=O)c2cncc(N(C)C)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3956712 IC50 1.449 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1ccnc(N2CCO[C@H](CNC(=O)CO)C2)c1 CHEMBL4110211 IC50 1.495 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1 CHEMBL1946170 IC50 1.5 nM
CNc1cc2nc(C)c(-c3ccc(F)c(NC(=O)NCCC(C)(C)C)c3)cc2cn1 CHEMBL3577120 IC50 1.6 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4cccc(F)c4[nH]3)ccnc2N1 CHEMBL3908760 IC50 1.6 nM
Cc1ccc(NC(=O)c2cc(C(F)(F)F)cnn2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5078176 IC50 1.6 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc2[nH]cnc2c(N2CCOCC2)n1 CHEMBL3971983 IC50 1.619 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4ccc(Br)cc4[nH]3)ccnc2N1 CHEMBL3916469 IC50 1.7 nM
CO[C@H]1COCC[C@@H]1Oc1ncc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)cnc2C)cc1N1CCOCC1 CHEMBL4475855 IC50 1.7 nM
CN(C)CCOc1ccc(-c2nc(-c3ccncc3)c(-c3ccc4c(c3)CC/C4=N\O)[nH]2)cc1 CHEMBL477989 Ki(app) 1.72 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(N2CCOC[C@H]2C)c1 CHEMBL4109451 IC50 1.768 nM
Cc1cnc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5080346 IC50 1.8 nM
Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3931624 IC50 1.829 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C(C)C)c1 CHEMBL3970403 IC50 1.937 nM
Cc1ncc(NC(=O)c2cccc(S(C)(=O)=O)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3946530 IC50 1.947 nM
CN1CCCN(CCNc2nccc(-c3c(-c4cccc(O)c4)nc4sccn34)n2)S1(=O)=O CHEMBL5079413 IC50 1.96 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CC3CC(C2)O3)c(=O)n(C)c1 CHEMBL3952174 IC50 1.991 nM
COc1cc(C(=O)Nc2cnc(C)c(-c3ccnc(N4CCOCC4)c3)c2)ccc1F CHEMBL3891470 IC50 1.993 nM
CNc1nccc(-c2[nH]c(C(F)(F)F)nc2-c2cccc(NC(=O)Cc3ccc(Cl)cc3)c2)n1 CHEMBL258454 IC50 2.0 nM
CNC(=O)c1cc(Oc2ccc3sc(Nc4ccc(Br)cc4)nc3c2)ccn1 CHEMBL1778405 IC50 2.0 nM
CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(OC(F)(F)F)cc4)nc3c2)ccn1 CHEMBL1778397 IC50 2.0 nM
CCCCc1ccc(Nc2nc3cc(Oc4ccnc(C(=O)NC)c4)ccc3o2)cc1 CHEMBL1778396 IC50 2.0 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(OCCOP(=O)(O)O)nc(N2CCOC[C@H]2C)c1 CHEMBL3892987 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)ncn1 CHEMBL4105276 IC50 2.0 nM
Cc1ccc(NC(=O)c2nccc(C(F)(F)F)n2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5091400 IC50 2.0 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4ccc(F)cc4[nH]3)ccnc2N1 CHEMBL3982542 IC50 2.1 nM
CCn1cc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)cnc2C)cc(N2CCOCC2)c1=O CHEMBL3964820 IC50 2.134 nM
CN(C)Cc1cc(C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688860 IC50 2.2 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)nc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5072183 IC50 2.2 nM
COC(=O)NCCn1cc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)cc(N2CCOCC2)c1=O CHEMBL3910040 IC50 2.225 nM
CCN1CCN(c2cc(C(=O)Nc3ccc(C)c(-c4cc(N5CCOCC5)c(=O)n(C)c4)c3)cc(C(F)(F)F)c2)CC1 CHEMBL3969209 IC50 2.238 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc(N2CCOCC2)c(=O)n(CCO)c1 CHEMBL3925508 IC50 2.261 nM
COc1cc(C(=O)Nc2cnc(C)c(-c3cc(N4CCOCC4)c(=O)n(C)c3)c2)ccc1F CHEMBL3935937 IC50 2.263 nM
COc1cccc(-c2nc3sccn3c2-c2ccnc(NCCN3CCCN(C)S3(=O)=O)n2)c1 CHEMBL5073246 IC50 2.33 nM
COc1ncc(-c2cc(NC(=O)c3ccnc(C(C)(C)C#N)c3)cnc2C)cc1N1CCOCC1 CHEMBL3892757 IC50 2.331 nM
O=C(NOCC1CC1)c1ccc(F)c(F)c1Nc1ccc(I)cc1Cl CHEMBL105442 IC50 2.45 nM
CC(C)(N)c1cc(C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688861 IC50 2.5 nM
Cc1cc2[nH]c(C3[C@H]4Oc5ccc(Oc6ccnc7c6CCC(=O)N7)cc5[C@@H]34)nc2cc1F CHEMBL3925378 IC50 2.5 nM
O=C1CCc2c(Oc3ccc4c(c3)[C@H]3C(c5nc6cc(Cl)c(C(F)(F)F)cc6[nH]5)[C@H]3O4)ccnc2N1 CHEMBL3900761 IC50 2.5 nM
Cn1cc(-c2cc(C(=O)Nc3cccc(C(F)(F)F)c3)ccc2C(F)F)cc(N2CCOCC2)c1=O CHEMBL3918963 IC50 2.507 nM
COc1cccc(-c2nc3sccn3c2-c2ccnc(NCCN3CCN(C)S3(=O)=O)n2)c1 CHEMBL5080553 IC50 2.52 nM
Cc1ccc(NC(=O)c2cc(C(F)(F)F)cnn2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2CCO CHEMBL5079497 IC50 2.6 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(CCO)c1 CHEMBL3897441 IC50 2.686 nM
Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C1(c2ncnc3[nH]ccc23)CC1 CHEMBL4438236 IC50 2.7 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc2[nH]cnc2c(N2CCOC[C@H]2C)n1 CHEMBL4113683 IC50 2.729 nM
CNc1ncc2cc(-c3ccc(F)c(NC(=O)NCCC(C)(C)C)c3)c(C)nc2n1 CHEMBL3577119 IC50 2.8 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1NC(=O)c1cccc2c(N)nccc12 CHEMBL3973348 IC50 2.8 nM
Oc1c(Br)cc(C=C2c3cc(I)ccc3NC2O)cc1Br CHEMBL1794051 IC50 2.87 nM
COc1ccc(Cn2ncc(NC(=O)c3cc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)ccc3C)c2N)cc1 CHEMBL1684800 IC50 2.87 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(CCS(C)(=O)=O)c1 CHEMBL3981967 IC50 2.897 nM
CCn1c(=O)c(-c2ccc(F)c(NC(=O)Nc3cc(C(C)(C)C)no3)c2)cc2cnc(NC)cc21 CHEMBL3577115 IC50 2.9 nM
O=C(Nc1cc(Oc2cccc3[nH]c(=O)[nH]c23)c(F)c(F)c1F)c1cccc(OC(F)(F)F)c1 CHEMBL602123 IC50 3.0 nM
CNC(=O)c1cc(Oc2ccc3sc(Nc4ccc(C(C)C)cc4)nc3c2)ccn1 CHEMBL1778408 IC50 3.0 nM
CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(Br)cc4)nc3c2)ccn1 CHEMBL1778393 IC50 3.0 nM
CNC(=O)c1cc(Oc2ccc3oc(Nc4cccc(C(C)C)c4)nc3c2)ccn1 CHEMBL1778392 IC50 3.0 nM
Cn1c(Nc2ccc(C(F)(F)F)cc2)nc2ccc(Oc3ccnc(-c4cnc(C(F)(F)F)[nH]4)c3)cc21 CHEMBL1946171 IC50 3.0 nM
O=C1CCc2c(Oc3ccc4c(c3)[C@@H]3C(c5nc6cc(Cl)c(Cl)cc6[nH]5)[C@@H]3O4)ccnc2N1 CHEMBL4111990 IC50 3.0 nM
Cc1ncc(NC(=O)c2ccnc(S(C)(=O)=O)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3975841 IC50 3.089 nM
CNc1cc2c(cn1)cc(-c1ccc(F)c(NC(=O)Nc3cc(C(C)(C)C)no3)c1)c(=O)n2[C@H]1CCOC1 CHEMBL3577114 IC50 3.1 nM
O=C1Nc2nccc(Oc3ccc4c(c3)C3C(O4)C3c3nc4ccc(C(F)(F)F)cc4[nH]3)c2CO1 CHEMBL3975782 IC50 3.2 nM
Cc1cc(F)c(NC(=O)Cc2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5086851 IC50 3.2 nM
Cc1ccc(NC(=O)c2cnnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5082939 IC50 3.2 nM
CN(C)Cc1cc(NC(=O)[C@H]2CCc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688871 IC50 3.3 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F CHEMBL1230020 Ki 3.3 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4cc(F)c(F)cc4[nH]3)ccnc2N1 CHEMBL3935563 IC50 3.3 nM
Cc1ccc(NC(=O)c2cncc(C(F)(F)F)n2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5072876 IC50 3.3 nM
Cc1ccc(NC(=O)C2CCNC(C(F)(F)F)C2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5081306 IC50 3.3 nM
Cc1ccc(NC(=O)c2cc(OC3CC3)cnn2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5078558 IC50 3.4 nM
O=C1CC2(CCOCC2)Oc2cc(-c3cc(NC(=O)c4ccnc(C(F)(F)F)c4)ccc3CO)ccc2N1 CHEMBL5080743 IC50 3.5 nM
Cn1c(C2C3Oc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C32)nc2ccccc21 CHEMBL3931164 IC50 3.6 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CNC2=O CHEMBL5069433 IC50 3.6 nM
COc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5071025 IC50 3.6 nM
COc1ccc2nc(C3C4Oc5ccc(Oc6ccnc7c6CCC(=O)N7)cc5C43)[nH]c2c1 CHEMBL3961208 IC50 3.8 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)NC2=O CHEMBL5177739 IC50 3.8 nM
COc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3942611 IC50 3.837 nM
Cc1ccc(NC(=O)c2cc(C(F)(F)F)cnn2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2C CHEMBL5093788 IC50 3.9 nM
O=S1(=O)N(CCNc2nccc(-c3c(-c4cccc(O)c4)nc4sccn34)n2)CCN1Cc1ccccc1 CHEMBL5092329 IC50 3.91 nM
Cc1cc(O)cc(C)c1/C=C/c1cncc(-c2nn[nH]n2)c1 CHEMBL218791 IC50 4.0 nM
CNC(=O)c1cc(Oc2ccc3c(c2)nc(Nc2cccc(Br)c2)n3C)ccn1 CHEMBL471625 IC50 4.0 nM
CNC(=O)c1cc(Oc2ccc3c(c2)nc(Nc2cccc(C(C)(C)C)c2)n3C)ccn1 CHEMBL470808 IC50 4.0 nM
Cn1c(Nc2ccc(Br)cc2)nc2cc(Oc3ccnc(C(=O)NCCO)c3)ccc21 CHEMBL486137 IC50 4.0 nM
CNC(=O)c1cc(Oc2ccc3sc(Nc4ccc(OC(F)(F)F)cc4)nc3c2)ccn1 CHEMBL1778409 IC50 4.0 nM
CNC(=O)c1cc(Oc2ccc3sc(Nc4ccc(Cl)cc4)nc3c2)ccn1 CHEMBL1778404 IC50 4.0 nM
CC(C)c1cccc(Nc2nc3cc(Oc4ccnc(C(N)=O)c4)ccc3o2)c1 CHEMBL1778401 IC50 4.0 nM
COCCNS(=O)(=O)Nc1cccc(Cc2c(C)c3cc(Cl)c(OC(=O)N(C)C)cc3oc2=O)c1 CHEMBL3086075 IC50 4.0 nM
Cc1c(Cc2cccc(NS(=O)(=O)NCCC#N)c2)c(=O)oc2cc(OC(=O)N(C)C)c(Cl)cc12 CHEMBL3086073 IC50 4.0 nM
O=C1CCc2c(Oc3ccc4c(c3)[C@H]3C(c5nc6cc(Cl)c(Cl)cc6[nH]5)[C@H]3O4)ccnc2N1 CHEMBL3946670 IC50 4.0 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4ccc(Cl)cc4[nH]3)ccnc2N1 CHEMBL3891968 IC50 4.1 nM
Cc1ccc(NC(=O)c2ccnc(OC(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5083789 IC50 4.1 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4cc(C(F)(F)F)ccc4n3CCO)ccnc2N1 CHEMBL3938706 IC50 4.2 nM
CC1(C)CN(CCNc2nccc(-c3c(-c4cccc(O)c4)nc4sccn34)n2)S(=O)(=O)N1 CHEMBL5088891 IC50 4.26 nM
Cn1c(C2C3Oc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C32)nc2cc(C(F)(F)F)ccc21 CHEMBL3937407 IC50 4.3 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CNC2 CHEMBL5094293 IC50 4.3 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOC1)NC2=O CHEMBL5179150 IC50 4.3 nM
COc1cccc(-c2nc3sccn3c2-c2ccnc(NCCN3CCN(Cc4ccccc4)S3(=O)=O)n2)c1 CHEMBL5088157 IC50 4.32 nM
O=C1Nc2ccc(I)cc2/C1=C/c1cc(Br)c(O)c(Br)c1 CHEMBL72365 IC50 4.4 nM
CC(C)(C)c1ccc2nc(C3C4Oc5ccc(Oc6ccnc7c6CCC(=O)N7)cc5C43)[nH]c2c1 CHEMBL3915194 IC50 4.4 nM
NCc1cc(NC(=O)[C@H]2CCc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688869 IC50 4.5 nM
N#Cc1ccc2nc(C3C4Oc5ccc(Oc6ccnc7c6CCC(=O)N7)cc5C43)[nH]c2c1 CHEMBL3893187 IC50 4.5 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4ccncc4[nH]3)ccnc2N1 CHEMBL3930140 IC50 4.5 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2C CHEMBL5091230 IC50 4.5 nM
CC(C)NCc1cc(NC(=O)C2CCc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688872 IC50 4.6 nM
Cc1cc(F)c(NC(=O)N(C)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5091700 IC50 4.7 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)NC1(CCOCC1)NC2=O CHEMBL5171296 IC50 4.8 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)cn(C)c1=O CHEMBL3930988 IC50 4.813 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4cc(Cl)c(Cl)cc4[nH]3)ccnc2N1 CHEMBL3961774 IC50 4.9 nM
CNc1nccc(-c2[nH]c(C3CC3)nc2-c2cccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c2)n1 CHEMBL430413 IC50 5.0 nM
Cc1c(Cc2cccc(NS(N)(=O)=O)c2F)c(=O)oc2cc(OC(=O)N(C)C)c(F)cc12 CHEMBL3086078 IC50 5.0 nM
Cc1c(Cc2cccc(NS(=O)(=O)N(C)C)c2)c(=O)oc2cc(OC(=O)N(C)C)c(Cl)cc12 CHEMBL3086066 IC50 5.0 nM
COc1ccc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)cc1 CHEMBL3894601 IC50 5.0 nM
Cc1ccc2c(Nc3cccc(Cl)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12 CHEMBL3954810 IC50 5.0 nM
Cc1ccc2c(Nc3cccc(Cl)c3F)nccc2c1NC(=O)c1csc2c(N)ncnc12 CHEMBL3977543 IC50 5.0 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4cc(Cl)c(C(F)(F)F)cc4[nH]3)ccnc2N1 CHEMBL3956392 IC50 5.0 nM
Cc1ncc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5073582 IC50 5.0 nM
O=S(=O)(NCCCNc1nccc(-c2c(-c3cccc(O)c3)nc3sccn23)n1)c1cccc(F)c1 CHEMBL5086749 IC50 5.0 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCS(=O)(=O)CC1)NC2=O CHEMBL5172219 IC50 5.0 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCCOC1)NC2=O CHEMBL5194797 IC50 5.0 nM
CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1 CHEMBL2028663 IC50 5.0 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5087151 IC50 5.1 nM
CCn1c(=O)c(-c2cc(NC(=O)NCCC(C)(C)C)c(F)cc2C)cc2cnc(NC)cc21 CHEMBL3577116 IC50 5.2 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCN2)CCOCC1 CHEMBL5091604 IC50 5.4 nM
Cc1ccc(NC(=O)c2cncc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5075553 IC50 5.4 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(C4)C3c3nc4ccccc4s3)ccnc2N1 CHEMBL3959654 IC50 5.5 nM
Cc1ccc(NC(=O)c2cc(C(F)(F)F)ncn2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5094887 IC50 5.5 nM
Cc1ncc(NC(=O)c2ccnc(C(C)(C)C)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3966297 IC50 5.505 nM
CNc1cc2nc(C)c(-c3cc(NC(=O)NCCC(C)(C)C)c(F)cc3C)cc2cn1 CHEMBL3577121 IC50 5.6 nM
COc1cccc(-c2nc3sccn3c2-c2ccnc(NCCN3CCNS3(=O)=O)n2)c1 CHEMBL5075811 IC50 5.61 nM
COc1cccc(-c2nc3sccn3c2-c2ccnc(NCCN3CC(C)(C)NS3(=O)=O)n2)c1 CHEMBL5092112 IC50 5.63 nM
Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3934389 IC50 5.762 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4cc(Cl)c(F)cc4[nH]3)ccnc2N1 CHEMBL3975784 IC50 5.9 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Br)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL350747 IC50 6.0 nM
CNC(=O)Oc1cc(C)c(/C=C/c2cncc(C(=O)O)c2)c(C)c1 CHEMBL220019 IC50 6.0 nM
CNC(=O)c1cc(Oc2ccc3c(c2)nc(Nc2cccc(C(F)(F)F)c2)n3C)ccn1 CHEMBL513562 IC50 6.0 nM
CC(=O)Nc1cc(Oc2ccc3c(c2)C[C@@H](C(=O)Nc2cc(CN)cc(C(F)(F)F)c2)CC3)ccn1 CHEMBL1688867 IC50 6.0 nM
NCc1cc(NC(=O)[C@@H]2CCc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688870 IC50 6.0 nM
Cc1c(Cc2cccc(NS(=O)(=O)NCCO)c2)c(=O)oc2cc(OC(=O)N(C)C)c(Cl)cc12 CHEMBL3086074 IC50 6.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(OCCOP(=O)(O)O)nc(N2CCOC[C@H]2C)c1 CHEMBL3958235 IC50 6.0 nM
Cc1ccc2c(Nc3ccc(Cl)c(CN(C)C)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12 CHEMBL3982491 IC50 6.0 nM
O=S(=O)(NCCNc1nccc(-c2c(-c3cccc(O)c3)nc3sccn23)n1)c1ccc(F)cc1 CHEMBL5083036 IC50 6.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1NC(=O)c1cccc2c(N)nccc12 CHEMBL3967980 IC50 6.1 nM
NCc1cc(NC(=O)C2CCc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688868 IC50 6.2 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4cccc(C(F)(F)F)c4[nH]3)ccnc2N1 CHEMBL3933329 IC50 6.2 nM
CNc1cc(C2(C(=O)Nc3cc(C(=O)Nc4ccc(OCC5CCN(C)CC5)c(C(F)(F)F)c4)ccc3C)CC2)ncn1 CHEMBL4080362 IC50 6.3 nM
O=S1(=O)NCCN1CCNc1nccc(-c2c(-c3cccc(O)c3)nc3sccn23)n1 CHEMBL5076688 IC50 6.32 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c[nH]c1=O CHEMBL3928661 IC50 6.383 nM
CCN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(NC(=O)c4cccc5c(NC(C)(C)C)nccc45)c3)cc2C(F)(F)F)CC1 CHEMBL3944893 IC50 6.4 nM
CNC(=O)c1cc(Oc2ccc3c(c2)C2C(O3)C2c2nc3ccc(C(F)(F)F)cc3[nH]2)ccn1 CHEMBL3943552 IC50 6.5 nM
OCCn1cc(-c2ccc3c(c2)CCC3=NO)c(-c2ccncc2)n1 CHEMBL2139930 Kd 6.6 nM
CNc1cc2nc(C)c(-c3cc(NC(=O)NCCC(C)(C)C)ccc3C)cc2cn1 CHEMBL3577118 IC50 6.7 nM
Cc1cc(F)c(NC(=O)Nc2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5076588 IC50 6.7 nM
CNC(=O)Oc1cc(C)c(/C=C/c2cncc(C(N)=O)c2)c(C)c1 CHEMBL219870 IC50 7.0 nM
CNC(=O)c1cc(Oc2ccc3sc(Nc4ccc(C)cc4)nc3c2)ccn1 CHEMBL1778406 IC50 7.0 nM
CC(=O)c1ccc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)cc1 CHEMBL3944137 IC50 7.0 nM
O=C1CCc2c(Oc3ccc4c(c3)[C@H]3[C@@H](O4)[C@@H]3c3nc4ccc(C(F)(F)F)cc4[nH]3)ccnc2N1 CHEMBL4207519 IC50 7.0 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCSCC1)NC2=O CHEMBL5200232 IC50 7.0 nM
Cc1ccc(NC(=O)c2ccnc(C3CC3)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5090164 IC50 7.1 nM
CNc1cc2nc(C)c(-c3cc(NC(=O)NC[C@@H](O)C(C)(C)C)c(F)cc3C)cc2cn1 CHEMBL3577117 IC50 7.2 nM
O=S1(=O)NCCCN1CCNc1nccc(-c2c(-c3cccc(O)c3)nc3sccn23)n1 CHEMBL5079502 IC50 7.21 nM
COc1cccc(-c2nc3sccn3c2-c2ccnc(NCCN3CCCNS3(=O)=O)n2)c1 CHEMBL5089022 IC50 7.22 nM
Cc1ncc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 CHEMBL3970281 IC50 7.674 nM
CNC(=O)c1cc(Oc2ccc3[nH]c(Nc4cccc(C(C)(C)C)c4)nc3c2)ccn1 CHEMBL511997 IC50 8.0 nM
CNS(=O)(=O)Nc1cccc(Cc2c(C)c3cc(Cl)c(OC(=O)N(C)C)cc3oc2=O)c1 CHEMBL3086065 IC50 8.0 nM
CNS(=O)(=O)Nc1cccc(Cc2c(C)c3ccc(OC(=O)N(C)C)cc3oc2=O)c1F CHEMBL3092191 IC50 8.0 nM
O=C(NCCNc1nccc(-c2c(-c3cccc(O)c3)nc3sccn23)n1)c1ccccc1 CHEMBL1915474 IC50 8.2 nM
CNc1cc(C2(C(=O)Nc3cc(C(=O)Nc4ccc(OC5CCN(C)CC5)c(C(F)(F)F)c4)ccc3C)CC2)ncn1 CHEMBL4066939 IC50 8.5 nM
Cn1ccc2c(Oc3ccc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)cc3)ncnc21 CHEMBL4173438 IC50 8.5 nM
CN1C[C@@H]2C[C@H]1CN2c1cc(F)c(-c2ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn23)c(F)c1 CHEMBL1276179 IC50 8.52 nM
C[C@H](O)CNc1nccc(-n2ccnc2Cc2cccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c2)n1 CHEMBL3309549 IC50 8.79 nM
O=C1CCc2c(Oc3ccc4c(c3)[C@@H]3C(c5nc6ccc(C(F)(F)F)cc6[nH]5)[C@@H]3O4)ccnc2N1 CHEMBL4110100 IC50 8.8 nM
O=C1Nc2ccc(I)cc2/C1=C\c1cc(Br)c(O)c(Br)c1 CHEMBL264949 IC50 9.0 nM
CNC(=O)c1cc(Oc2ccc3c(c2)nc(Nc2ccc(C(F)(F)F)cc2)n3C)ccn1 CHEMBL470591 IC50 9.0 nM
CNC(=O)c1cc(Oc2ccc3c(c2)nc(Nc2ccc(C(C)(C)C)cc2)n3C)ccn1 CHEMBL511836 IC50 9.0 nM
CNC(=O)c1cc(Oc2cccc(CCC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c2)ccn1 CHEMBL1688863 IC50 9.0 nM
CCCCc1ccc(Nc2nc3cc(Oc4ccnc(C(=O)NC)c4)ccc3s2)cc1 CHEMBL1778407 IC50 9.0 nM
Cc1ccc(NC(=O)c2cc(OCCO)nc(OC(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5082738 IC50 9.2 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4ccc(OC(F)(F)F)cc4[nH]3)ccnc2N1 CHEMBL3944431 IC50 9.7 nM
CC(C)(C)OC(=O)N1CCCN(CCNc2nccc(-c3c(-c4cccc(O)c4)nc4sccn34)n2)S1(=O)=O CHEMBL5077895 IC50 9.98 nM
CNC(=O)Oc1cc(C)c(/C=C/c2cncc(C(=O)NC)c2)c(C)c1 CHEMBL218932 IC50 10.0 nM
CNC(=O)c1cc(Oc2ccc3c(c2)nc(Nc2ccccc2Br)n3C)ccn1 CHEMBL471415 IC50 10.0 nM
CNC(=O)c1cc(Oc2ccc3c(c2)nc(Nc2cccc(-c4ccncc4)c2)n3C)ccn1 CHEMBL514135 IC50 10.0 nM
CNC(=O)c1cc(Oc2ccc(CCC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1688862 IC50 10.0 nM
Cc1ccc(NC(=O)N2CC[C@@H](CC(F)(F)F)C2)cc1-c1cnc(OCCN2CCN(c3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)c(N2CCOCC2)c1 CHEMBL5206031 IC50 10.0 nM
Cc1ncc(NC(=O)N2CC[C@@H](CC(F)(F)F)C2)cc1-c1cnc(OCCN2CCN(c3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)c(N2CCOCC2)c1 CHEMBL5204719 IC50 10.0 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(N2C[C@H](CN(C)C)OC[C@@H]2C)c1 CHEMBL3948046 IC50 10.12 nM
O=C(Nc1ccc(Oc2ccnc(-c3ncc(C(F)(F)F)[nH]3)c2)cc1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL2047981 IC50 10.6 nM
Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)c1cccc2c(N)nccc12 CHEMBL3974325 IC50 10.7 nM
O=C1Nc2ccc(-c3cccnc3)cc2C1=Cc1cc(Br)c(O)c(Br)c1 CHEMBL1794050 IC50 11.0 nM
CC(C)(C)c1cc(NC(=O)Nc2cccc(Cl)c2Cl)n(-c2cccc(CC(N)=O)c2)n1 CHEMBL1271376 IC50 11.0 nM
CNC(=O)c1cc(Oc2ccc3c(c2)CC(C(=O)Nc2cc(CN)cc(C(F)(F)F)c2)CC3)ccn1 CHEMBL1688866 IC50 11.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1NC(=O)c1cccc2c(NC(C)(C)C)nccc12 CHEMBL3976388 IC50 11.0 nM
COC(=O)NCCn1cc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)cnc2C)cc(N2CCOCC2)c1=O CHEMBL3894464 IC50 11.05 nM
COc1cccc(-c2nc3sccn3c2-c2ccnc(NCCN3CCCN(C(=O)OC(C)(C)C)S3(=O)=O)n2)c1 CHEMBL5076765 IC50 11.21 nM
Cc1ccc(NC(=O)c2cc(C(F)(F)F)ccn2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5077689 IC50 11.3 nM
CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(N(C)C)cc4)nc3c2)ccn1 CHEMBL1778399 IC50 12.0 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(C4)C3c3nc4ccc(C(F)(F)F)cc4[nH]3)ccnc2N1 CHEMBL3923069 IC50 12.0 nM
Cc1cc(Oc2ccnc3c2CCC(=O)N3)cc2c1OC1C(c3nc4ccc(C(F)(F)F)cc4[nH]3)C21 CHEMBL3923954 IC50 12.0 nM
COC(=O)c1ccc2c(c1)C(=Cc1cc(Br)c(O)c(Br)c1)C(=O)N2 CHEMBL1794052 IC50 13.0 nM
NC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL403732 IC50 13.0 nM
Cc1c(Cc2cccc(NS(N)(=O)=O)c2F)c(=O)oc2cc(OC(=O)N(C)C)ccc12 CHEMBL3092185 IC50 13.0 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CN(CCN(C)C)C2=O CHEMBL5081878 IC50 13.0 nM
Cc1ccc(NC(=O)N2CCCC(C(F)(F)F)C2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5077690 IC50 13.0 nM
Cc1ccc(S(=O)(=O)NCCCNc2nccc(-c3c(-c4cccc(O)c4)nc4sccn34)n2)cc1 CHEMBL5077391 IC50 13.0 nM
O=C(Nc1ccc(Oc2ccnc(-c3ncc(C(F)(F)F)[nH]3)c2)cc1)Nc1ccc(Cl)c(Cl)c1 CHEMBL2047982 IC50 13.1 nM
Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C1(c2cc(NCCCN3CCN(C)CC3)ncn2)CC1 CHEMBL4075036 IC50 13.3 nM
Cc1ccc(C(=O)Nc2ccc(C(F)(F)F)c(Cl)c2)cc1NC(=O)C1(c2cc(NCCCN3CCN(C)CC3)ncn2)CC1 CHEMBL4282601 IC50 13.3 nM
O=C(Nc1cccc(-c2nc(C3CC3)[nH]c2-c2ccnc(NCCN3CCNC3=O)n2)c1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL256921 IC50 14.0 nM
CCNC(=O)c1cc(Oc2ccc3c(c2)nc(Nc2ccc(Br)cc2)n3C)ccn1 CHEMBL470359 IC50 14.0 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)C(=O)N2 CHEMBL5202806 IC50 14.0 nM
CNc1cc(C2(C(=O)Nc3cc(C(=O)Nc4ccc(OCCCN5CCOCC5)c(C(F)(F)F)c4)ccc3C)CC2)ncn1 CHEMBL4104590 IC50 14.4 nM
CNC(=O)c1cc(Oc2ccc3[nH]c(Nc4ccc(C(C)(C)C)cc4)nc3c2)ccn1 CHEMBL471407 IC50 15.0 nM
CNC(=O)c1cc(Oc2ccc3c(c2)nc(Nc2ccc(Cl)c(C(F)(F)F)c2)n3C)ccn1 CHEMBL470364 IC50 15.0 nM
CNC(=O)c1cc(Oc2ccc3nc(NC(=O)Nc4ccc(Cl)c(Cl)c4)sc3c2)ccn1 CHEMBL3798983 IC50 15.0 nM
Cc1ccc2c(Nc3ccc(F)c(Cl)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12 CHEMBL3915720 IC50 15.0 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC2=O CHEMBL5206780 IC50 15.0 nM
Nc1nc2c3c(ccc2s1)NC(=O)/C3=C\c1cc(Br)c(O)c(Br)c1 CHEMBL418892 IC50 16.0 nM
CNC(=O)c1cc(Oc2ccc3c(c2)CC(C(=O)Nc2ccc(CN)c(C(F)(F)F)c2)CC3)ccn1 CHEMBL1688865 IC50 16.0 nM
Cc1c(Cc2cccc(NS(=O)(=O)N3CCN(C)CC3)c2)c(=O)oc2cc(OC(=O)N(C)C)c(Cl)cc12 CHEMBL3086076 IC50 16.0 nM
O=C(Nc1ccc(Cl)c(Cl)c1)Nc1ccc(Oc2ccnc(-c3ncc(C(F)(F)F)[nH]3)c2)cc1Cl CHEMBL2047994 IC50 16.5 nM
NC(=O)c1cccc(Nc2nccc(-c3[nH]c(C(F)(F)F)nc3-c3cccc(NC(=O)Cc4ccc(Cl)cc4)c3)n2)c1 CHEMBL256775 IC50 17.0 nM
Cn1c(Nc2ccc(Br)cc2)nc2cc(Oc3ccnc(C(=O)NCCC4CNCCO4)c3)ccc21 CHEMBL511119 IC50 17.0 nM
Cc1ccc(C(=O)Nc2ccc(C(F)(F)F)c(Cl)c2)cc1NC(=O)C1(c2ccnc(NCCN3CCN(C)CC3)n2)CC1 CHEMBL4289810 IC50 17.5 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)cn(C)c1=O CHEMBL3927611 IC50 17.98 nM
O=C1Nc2ccc(C(=O)c3ccccc3)cc2/C1=C/c1cc(Br)c(O)c(Br)c1 CHEMBL73554 IC50 18.0 nM
CCn1c(Nc2ccc(Br)cc2)nc2cc(Oc3ccnc(C(=O)NC)c3)ccc21 CHEMBL470149 IC50 18.0 nM
O=S(=O)(NCCCNc1nccc(-c2c(-c3cccc(F)c3)nc3sccn23)n1)c1ccc(Br)cc1 CHEMBL4757872 IC50 18.6 nM
Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C1(c2cc(NCCCN(C)C)ncn2)CC1 CHEMBL4087837 IC50 18.7 nM
CNC(=O)c1cc(Oc2ccc3[nH]c(Nc4ccc(Br)cc4)nc3c2)ccn1 CHEMBL472448 IC50 19.0 nM
CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(Cl)cc4)nc3c2)ccn1 CHEMBL1162958 IC50 19.0 nM
Cn1c(Nc2ccc(C(F)(F)F)cc2)nc2cc(Oc3ccnc(-c4ncc(C(F)(F)F)[nH]4)c3)ccc21 CHEMBL558752 IC50 19.0 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC2O CHEMBL5178194 IC50 19.0 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCNCC1)NC2=O CHEMBL5186258 IC50 19.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1C#Cc1nn(C2CCN(C)CC2)c2ncnc(N)c12 CHEMBL4787515 IC50 19.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)n2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5091523 IC50 19.7 nM
Clc1ccc(-c2[nH]c(-c3ccccc3)nc2-c2ccncc2)cc1Cl CHEMBL69929 IC50 20.0 nM
O=C(Cc1ccc(Cl)cc1)Nc1cccc(-c2nc(C(F)(F)F)[nH]c2-c2ccnc(NCCN3CCNC3=O)n2)c1 CHEMBL254965 IC50 20.0 nM
CNC(=O)c1cc(Oc2ccc3[nH]c(Nc4ccc(C(F)(F)F)cc4)nc3c2)ccn1 CHEMBL472450 IC50 20.0 nM
CNc1cc2nc(C)c(-c3cc(NC(=O)NCCC(C)(C)C)ccc3F)cc2cn1 CHEMBL3891833 IC50 20.0 nM
FC(F)(F)c1ccc2nc(C3C4Oc5ccc(Oc6ncnc7[nH]cnc67)cc5C43)[nH]c2c1 CHEMBL3905022 IC50 20.0 nM
Cc1ccc(C(=O)Nc2ccc(OCC3CCN(C)CC3)c(C(F)(F)F)c2)cc1NC(=O)C1(c2ncnc3[nH]ccc23)CC1 CHEMBL4436132 IC50 20.0 nM
Cc1ccc(C(=O)Nc2ccccc2)cc1NC(=O)c1cccc2c(NC(C)(C)C)nccc12 CHEMBL3955345 IC50 20.5 nM
Cc1cccc(C)c1/C=C/n1cnc2c(Nc3ccc(P(C)(C)=O)cc3)ncnc21 CHEMBL488840 IC50 21.0 nM
CNS(=O)(=O)Nc1nccc(Cc2c(C)c3ccc(Oc4ccccc4)cc3oc2=O)c1F CHEMBL3263999 IC50 21.0 nM
O=C1CCc2c(Oc3ccc4c(c3)[C@@H]3C(c5nc6cc(Cl)c(C(F)(F)F)cc6[nH]5)[C@@H]3O4)ccnc2N1 CHEMBL4112979 IC50 21.0 nM
Cc1ccc(C(=O)Nc2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5080868 IC50 21.0 nM
O=S(=O)(NCCNc1nccc(-c2c(-c3cccc(O)c3)nc3sccn23)n1)c1ccccc1 CHEMBL5077573 IC50 21.0 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC2N CHEMBL5207072 IC50 21.0 nM
Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C1(c2cc(NCC3CCN(C)CC3)ncn2)CC1 CHEMBL4085294 IC50 21.4 nM
Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C1(c2cc(NCCN3CCCC3)ncn2)CC1 CHEMBL4082425 IC50 21.9 nM
COc1nnc(C(=O)Nc2ccc(C)c(-c3ccc4c(c3)OC3(CCOCC3)CC(=O)N4)c2)cc1C(F)(F)F CHEMBL5091780 IC50 22.0 nM
O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)Nc1ccc(Oc2ccnc(-c3ncc(C(F)(F)F)[nH]3)c2)cc1Cl CHEMBL2047992 IC50 22.1 nM
COc1ccc(Cn2ncc(NC(=O)c3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)c2N)cc1 CHEMBL1684784 IC50 22.41 nM
Oc1cccc(-c2nc(-c3ccccc3)[nH]c2-c2ccncc2)c1 CHEMBL304624 IC50 23.0 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 23.0 nM
CN(c1ccc(F)c(NC(=O)c2cccc(OC(C)(C)C#N)c2Cl)c1)c1ccc2nc(NC(=O)C3CC3)sc2n1 CHEMBL2204532 IC50 23.0 nM
CNS(=O)(=O)Nc1cccc(Cc2c(C)c3ccc(Oc4ncccn4)cc3oc2=O)c1F CHEMBL3092195 IC50 23.0 nM
Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1NC(=O)c1csc2c(N)ncnc12 CHEMBL3969260 IC50 23.0 nM
Cc1cc2nc(C3C4Oc5cc(Cl)c(Oc6ccnc7c6CCC(=O)N7)cc5C43)[nH]c2cc1F CHEMBL3902942 IC50 23.0 nM
O=S(=O)(NCCCNc1nccc(-c2c(-c3cccc(O)c3)nc3sccn23)n1)c1ccccc1 CHEMBL5094173 IC50 23.0 nM
Cc1ccc(NC(=O)c2cnccn2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3933886 IC50 24.0 nM
O=C1Nc2ccc(C(=O)C3CC3)cc2/C1=C/c1cc(Br)c(O)c(Br)c1 CHEMBL75988 IC50 25.0 nM
CN(C)Cc1ccc(-c2cnn3c(-c4cccc(NC(=O)c5cccc(C(F)(F)F)c5)c4)ccnc23)cc1 CHEMBL1087397 IC50 25.0 nM
CNS(=O)(=O)Nc1cccc(Cc2c(C)c3cc(I)c(OC(=O)N(C)C)cc3oc2=O)c1 CHEMBL3092178 IC50 25.0 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4c(Cl)cc(C(F)(F)F)cc4[nH]3)ccnc2N1 CHEMBL3907614 IC50 25.0 nM
CCNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL350129 IC50 26.0 nM
CNc1nccc(-c2[nH]c(C3CC3)nc2-c2cccc(NS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)c2)n1 CHEMBL402029 IC50 26.0 nM
Cc1c(Cc2cccc(NS(N)(=O)=O)c2)c(=O)oc2cc(OC(=O)N(C)C)c(Cl)cc12 CHEMBL3086064 IC50 26.0 nM
Cc1ccc(NC(=O)c2cc(OCCO)nc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5075142 IC50 26.0 nM
COc1ccc(S(=O)(=O)NCCCNc2nccc(-c3c(-c4cccc(F)c4)nc4sccn34)n2)cc1 CHEMBL4793221 IC50 26.1 nM
CCNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Br)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL168186 IC50 27.0 nM
CNC(=O)c1cc(Oc2ccc3oc(Nc4cccc(C(F)(F)F)c4)nc3c2)ccn1 CHEMBL1778391 IC50 27.0 nM
O=C(c1ccc(-c2ccccn2)s1)N1N=C(c2cccnc2)CC1c1ccccc1O CHEMBL1778666 IC50 27.0 nM
CCn1nc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(C)CC4)c(C(F)(F)F)c3)ccc2C)c2c(N)ncnc21 CHEMBL3426225 IC50 27.0 nM
CNC(=O)c1cc(Oc2ccc3c(c2)nc(NCC2CCCCC2)n3C)ccn1 CHEMBL472652 IC50 28.0 nM
CNC(=O)c1cc(Oc2ccc3c(c2)CC(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)CC3)ccn1 CHEMBL1688864 IC50 28.0 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(N2C[C@@H](CN(C)C)OC[C@H]2C)c1 CHEMBL4111018 IC50 28.0 nM
CNc1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)on3)c(C)c2)ncn1 CHEMBL4060295 IC50 28.0 nM
Cc1ccc(NC(=O)c2cc(C(F)(F)F)nn2C)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5089564 IC50 28.0 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cnc2c(c1)OC1(CCOCC1)NC2=O CHEMBL5181592 IC50 28.0 nM
O=C1Nc2ccc(S(=O)(=O)N(CCO)CCO)cc2/C1=C/c1cc(Br)c(O)c(Br)c1 CHEMBL311402 IC50 29.0 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC2NCCO CHEMBL5206492 IC50 29.0 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)SC1(CCOCC1)CC2=O CHEMBL5208877 IC50 29.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(OC(F)(F)F)cc3)cc2)ccn1 CHEMBL2397149 IC50 30.0 nM
NC(=O)c1cccc(Nc2nccc(-c3[nH]c(C4CC4)nc3-c3cccc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)c3)n2)c1 CHEMBL255496 IC50 31.0 nM
Cc1ccc(NC(=O)c2cccc(N(C)C)c2)cc1NC(=O)c1ccc(O)cc1 CHEMBL186526 IC50 31.0 nM
Cc1ccc(C(=O)Nc2ccc(OC3CCN(C)CC3)c(C(F)(F)F)c2)cc1NC(=O)C1(c2ncnc3[nH]ccc23)CC1 CHEMBL4586402 IC50 31.7 nM
O=C1Nc2ccc(-c3ccccc3)cc2/C1=C/c1cc(Cl)c(O)c(Cl)c1 CHEMBL73470 IC50 32.0 nM
CNS(=O)(=O)Nc1cc(Cc2c(C)c3ccc(OC(=O)N(C)C)cc3oc2=O)ccn1 CHEMBL3263996 IC50 32.0 nM
Cc1ccc2c(Nc3ccc(OC(F)F)cc3)nccc2c1NC(=O)c1csc2c(N)ncnc12 CHEMBL3965806 IC50 32.0 nM
O=C1CCc2c(Oc3cc4c(cc3Cl)OC3C(c5nc6ccc(C(F)(F)F)cc6[nH]5)C43)ccnc2N1 CHEMBL3973910 IC50 32.0 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CCO2 CHEMBL5083894 IC50 32.0 nM
Cc1ccc(NS(=O)(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5094015 IC50 32.0 nM
O=S(=O)(NCCCNc1nccc(-c2c(-c3cccc(F)c3)nc3sccn23)n1)c1ccc(Cl)cc1 CHEMBL4763823 IC50 34.0 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CN(CC(C)(C)O)C2=O CHEMBL5086530 IC50 34.0 nM
Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C1(c2cc(NCCN3CCCCC3)ncn2)CC1 CHEMBL4060531 IC50 34.5 nM
Cn1c(C2C3Oc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C32)nc2ccc(C(F)(F)F)cc21 CHEMBL3976907 IC50 35.0 nM
O=C(Nc1ccc(Oc2ccnc(-c3ncc(C(F)(F)F)[nH]3)c2)cc1Cl)Nc1cc(C(F)(F)F)ccc1Cl CHEMBL2047991 IC50 35.9 nM
O=C1CCc2c(Oc3cccc4c3OC3C(c5nc6ccc(C(F)(F)F)cc6[nH]5)C43)ccnc2N1 CHEMBL3912961 IC50 36.0 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC2 CHEMBL5180258 IC50 36.0 nM
COc1cc(-c2ccc3ncnc(Nc4cc(O)c(F)cc4F)c3c2)ccc1O CHEMBL3665859 IC50 36.3 nM
CONS(=O)(=O)Nc1cccc(Cc2c(C)c3cc(Cl)c(OC(=O)N(C)C)cc3oc2=O)c1 CHEMBL3086070 IC50 37.0 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)C(=O)CC1(CCOCC1)O2 CHEMBL5169383 IC50 37.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)on3)cc2)ccn1 CHEMBL353584 IC50 38.0 nM
COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C(F)(F)F)on4)c3)c2cc1OC CHEMBL2029988 Kd 39.0 nM
O=C1Nc2ccc(C(=O)c3ccco3)cc2/C1=C/c1cc(Cl)c(O)c(Cl)c1 CHEMBL73157 IC50 40.0 nM
CNC(=O)Oc1cc(C)c(/C=C/c2cncc(C#N)c2)c(C)c1 CHEMBL219745 IC50 40.0 nM
Cc1c(Cc2cccc(NS(=O)(=O)NCCN)c2)c(=O)oc2cc(OC(=O)N(C)C)c(Cl)cc12 CHEMBL3086072 IC50 40.0 nM
O=S(=O)(NCCNc1nccc(-c2c(-c3ccc(F)cc3)nc3sccn23)n1)c1ccc(O)cc1 CHEMBL4281099 IC50 40.0 nM
O=S(=O)(NCCCNc1nccc(-c2c(-c3cccc(F)c3)nc3sccn23)n1)c1ccc(C(F)(F)F)cc1 CHEMBL4794141 IC50 40.0 nM
O=C1NCCN1CCNc1nccc(-c2[nH]c(C3CC3)nc2-c2cccc(NS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)c2)n1 CHEMBL255497 IC50 41.0 nM
CCCC1CCCCN1C(=O)c1cc(Oc2ccc3c(c2)nc(Nc2ccc(Br)cc2)n3C)ccn1 CHEMBL486341 IC50 41.0 nM
O=C(NCCN1CCOCC1)c1cc(Oc2ccc3sc(Nc4ccc(Br)cc4)nc3c2)ccn1 CHEMBL1778411 IC50 41.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1sccc1NCc1ccnc2ccccc12 CHEMBL1614710 IC50 41.0 nM
CNc1nccc(C2(C(=O)Nc3cc(C(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)ccc3C)CC2)n1 CHEMBL4101882 IC50 43.4 nM
O=C(Nc1ccc(Oc2cccc(C(=O)Nc3cccnc3)c2)cc1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL165130 IC50 44.0 nM
O=C(Nc1ccc(Oc2ccnc(C(=O)Nc3cccnc3)c2)cc1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL514806 IC50 44.0 nM
Cc1ccc(NC(=O)c2cc(N3CCN(C)CC3)cc(C(F)(F)F)c2)cc1NC(=O)c1cnoc1C CHEMBL3616960 IC50 44.8 nM
CNC(=O)c1cc(Oc2ccc3nc(Nc4ccc(Br)cc4)n(C)c3c2)ccn1 CHEMBL520236 IC50 45.0 nM
CNCc1cc(C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688876 IC50 45.0 nM
Cc1c(Cc2cccc(NS(=O)(=O)NCC(F)(F)F)c2)c(=O)oc2cc(OC(=O)N(C)C)c(Cl)cc12 CHEMBL3086071 IC50 45.0 nM
O=C1Nc2ccc(C(=O)c3ccco3)cc2C1=Cc1cc(Cl)c(O)c(Cl)c1 CHEMBL1789963 IC50 46.0 nM
Cc1ccc(NC(=O)Nc2ccc(Oc3ccnc(-c4ncc(C(F)(F)F)[nH]4)c3)cc2Cl)cc1C(F)(F)F CHEMBL2047993 IC50 46.7 nM
CNC(=O)c1cc(Oc2ccc3c(c2)nc(Nc2ccccc2)n3C)ccn1 CHEMBL471408 IC50 48.0 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(Cl)cc4)cc23)c1F CHEMBL1229517 IC50 48.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 48.0 nM
Cc1ccc(-c2nnc(-c3ccnc(C(F)(F)F)c3)[nH]2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5078485 IC50 48.0 nM
NC(=O)c1cccc(Nc2nccc(-c3[nH]c(C4CC4)nc3-c3cccc(NS(=O)(=O)Cc4ccc(Cl)c(Cl)c4)c3)n2)c1 CHEMBL402424 IC50 49.0 nM
CNC(=O)c1cncc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)c1 CHEMBL163848 IC50 50.0 nM
Cc1cn(-c2cc(NC(=O)Nc3ccc(-c4nc5[nH]ncc5[nH]4)c(C)c3)cc(C(F)(F)F)c2)cn1 CHEMBL1084036 IC50 50.0 nM
CCS(=O)(=O)Nc1cccc(Cc2c(C)c3cc(Cl)c(OC(=O)N(C)C)cc3oc2=O)c1 CHEMBL3086069 IC50 50.0 nM
Cc1cc(Oc2cc(N3CCOCC3)ncn2)ccc1NC(=O)Nc1cc(C(C)(C)C)on1 CHEMBL4088518 IC50 51.0 nM
Cc1ccc(NC(=O)c2ccc(C)c(C(F)(F)F)c2)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12 CHEMBL4798527 IC50 52.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3OC)cc2)ccn1 CHEMBL164292 IC50 53.0 nM
CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(Oc5ccccc5)cc4)nc3c2)ccn1 CHEMBL1778398 IC50 53.0 nM
CNc1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)on3)cc2F)ncn1 CHEMBL4103211 IC50 53.0 nM
CNS(=O)(=O)Nc1cccc(Cc2c(C)c3cc(C#N)c(OC(=O)N(C)C)cc3oc2=O)c1 CHEMBL3092181 IC50 55.0 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)N(O)C1(CCOCC1)NC2=O CHEMBL5171848 IC50 55.0 nM
Clc1ccc(-c2nc(-c3ccccc3)[nH]c2-c2ccncc2)cc1 CHEMBL430419 IC50 56.0 nM
CNC(=O)c1cc(Oc2ccc3[nH]c(Nc4cccc(C(F)(F)F)c4)nc3c2)ccn1 CHEMBL511669 IC50 56.0 nM
Cc1c(Cc2cccc(NS(C)(=O)=O)c2)c(=O)oc2cc(OC(=O)N(C)C)c(Cl)cc12 CHEMBL3086068 IC50 56.0 nM
CNS(=O)(=O)Nc1nccc(Cc2c(C)c3ccc(Oc4ncccn4)cc3oc2=O)c1F CHEMBL3264002 IC50 56.0 nM
CNS(=O)(=O)Nc1nccc(Cc2c(C)c3ccc(Oc4cnccn4)cc3oc2=O)c1F CHEMBL3264001 IC50 56.0 nM
FC(F)(F)c1ccc2nc(C3C4Oc5ccc(Oc6ccnc(-c7nc(C(F)(F)F)c[nH]7)c6)cc5C43)[nH]c2c1 CHEMBL3967304 IC50 56.0 nM
O=C(Nc1ccc(Oc2ccnc(C(=O)NCCN3CCOCC3)c2)cc1)Nc1ccc(Br)c(C(F)(F)F)c1 CHEMBL164272 IC50 60.0 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)NC1(CCOCC1)NS2(=O)=O CHEMBL5197196 IC50 60.0 nM
CNC(=O)c1cncc(Oc2ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3OC)cc2)c1 CHEMBL353045 IC50 61.0 nM
CNC(=O)c1cc(Oc2cccc3nc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)ccc23)ccn1 CHEMBL4466297 IC50 61.0 nM
Cc1ccc(S(=O)(=O)NCCNc2nccc(-c3c(-c4cccc(O)c4)nc4sccn34)n2)cc1 CHEMBL5080054 IC50 62.0 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1ccc2c(c1)OC1(COC1)NC2=O CHEMBL5187431 IC50 62.0 nM
COc1ccc(C(F)(F)F)cc1NC(=O)Nc1ccc(Oc2cncc(C(=O)NCCN3CCOCC3)c2)cc1 CHEMBL352072 IC50 63.0 nM
CNS(=O)(=O)Nc1cccc(Cc2c(C)c3ccc(Oc4nccs4)cc3oc2=O)c1F CHEMBL3092176 IC50 63.0 nM
O=C(Nc1cccc(C(F)(F)F)c1)Nc1ccc(Oc2ccnc(-c3ncc(C(F)(F)F)[nH]3)c2)cc1Cl CHEMBL2047995 IC50 64.8 nM
O=C1Nc2ccc(C(=O)CCl)cc2/C1=C/c1cc(Br)c(O)c(Br)c1 CHEMBL72179 IC50 65.0 nM
COc1cc2cc(Oc3ccc(NC(=O)Nc4ccc(F)c(C(F)(F)F)c4)cc3)c(C)nc2cc1OCCN1CCOCC1 CHEMBL5202188 IC50 67.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3cccc(C(=O)Nc4cccnc4)c3)cc2)no1 CHEMBL167783 IC50 68.0 nM
Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1 CHEMBL436137 IC50 68.0 nM
Cc1ccc(NC(=O)c2ccc(C(F)(F)F)s2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5090428 IC50 69.0 nM
O=C(Nc1ccc(Oc2ccnc(-c3ncc(C(F)(F)F)[nH]3)c2)cc1)Nc1ccc(F)c(Cl)c1 CHEMBL2047983 IC50 69.2 nM
COc1cc(-c2ccc3ncnc(Nc4cc(O)c(Cl)cc4F)c3c2)ccc1O CHEMBL3665860 IC50 69.2 nM
O=C(Nc1ccc(Oc2cccc(C(=O)NCCN3CCOCC3)c2)cc1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL165283 IC50 70.0 nM
CN(C)Cc1cc(C(=O)N[C@@H]2CCc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688874 IC50 70.0 nM
C#Cc1cc2c(C)c(Cc3cccc(NS(=O)(=O)NC)c3)c(=O)oc2cc1OC(=O)N(C)C CHEMBL3092180 IC50 70.0 nM
CNS(=O)(=O)Nc1cccc(Cc2c(C)c3ccc(OC(=O)N(C)C)cc3oc2=O)n1 CHEMBL3263995 IC50 70.0 nM
Cc1ccc(CC(=O)c2cccc(N(C)C)c2)cc1NC(=O)c1ccc(O)cc1 CHEMBL5172162 IC50 70.0 nM
CNc1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(C)c2)ncn1 CHEMBL4088654 IC50 71.0 nM
O=C(Nc1ccc(Oc2ncnc3[nH]ncc23)cc1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL2332840 IC50 72.0 nM
O=C(Nc1ccc(Oc2ccnc(C(=O)NCCN3CCOCC3)c2)cc1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL165327 IC50 73.0 nM
Nc1ncnc2c(C(=O)Nc3c(Cl)ccc(NS(=O)(=O)CCCF)c3F)csc12 CHEMBL2047879 IC50 73.0 nM
CNC(=O)c1cc(O[C@H]2CC[C@H](NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)ccn1 CHEMBL2397141 IC50 75.0 nM
CNC(=O)c1cc(OC2CCC(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)CC2)ccn1 CHEMBL3928540 IC50 75.0 nM
O=S(=O)(NCCNc1nccc(-c2c(-c3ccccc3)nc3sccn23)n1)c1ccc(O)cc1 CHEMBL5092007 IC50 75.0 nM
O=C(Nc1ccc(Oc2ccnc(-c3ncc(C(F)(F)F)[nH]3)c2)cc1)Nc1cc(C(F)(F)F)ccc1Cl CHEMBL2047980 IC50 75.9 nM
CNC(=O)c1cc(Oc2ccc3nc(Nc4ccc(Cl)c(C(F)(F)F)c4)[nH]c3c2)ccn1 CHEMBL394826 IC50 76.0 nM
Cc1ccc(NC(=O)Nc2cc(Cl)cc(C(F)(F)F)c2)cc1-c1nc2c(cnn2Cc2ccccc2)[nH]1 CHEMBL1085603 IC50 76.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3cc(N4CCOCC4)ncn3)c(F)c2)no1 CHEMBL4065359 IC50 76.0 nM
O=C1Nc2ccc(I)cc2C1=Cc1cc(Br)c(O)c(Br)c1 CHEMBL1880739 IC50 77.0 nM
O=C(Nc1ccc(F)c(C(F)(F)F)c1)Nc1ccc(Oc2ccnc(-c3ncc(C(F)(F)F)[nH]3)c2)cc1Cl CHEMBL2047990 IC50 77.7 nM
Cc1ccc(NC(=O)c2cccnn2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3943932 IC50 77.92 nM
CNS(=O)(=O)Nc1cccc(Cc2c(C)c3cc(C)c(OC(=O)N(C)C)cc3oc2=O)c1 CHEMBL3092179 IC50 78.0 nM
Cc1ccc(NC(=O)c2ccnnc2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3921477 IC50 78.0 nM
CC(C)(N)c1cc(NC(=O)[C@H]2CCc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)cc(C(F)(F)F)c1 CHEMBL1614728 IC50 79.0 nM
Fc1ccc(-c2[nH]c(C3CCNCC3)nc2-c2ccncc2)cc1 CHEMBL69764 IC50 80.0 nM
Cc1ccc(NC(=O)c2ccnc(N3CCCCC3)c2)cc1-c1ccc(C(=O)NCC2CC2)cc1 CHEMBL476141 IC50 80.0 nM
CNC(=O)c1cc2ccc(CCNC(=O)Nc3cc(C(F)(F)F)c(Cl)cc3OC)cc2cn1 CHEMBL1760626 IC50 80.0 nM
Cc1cccc(Cn2nc(C)c3c(NC(=O)c4csc5c(N)ncnc45)cccc32)n1 CHEMBL4483816 IC50 80.0 nM
CNS(=O)(=O)Nc1nccc(Cc2c(C)c3ccc(Oc4ccccn4)cc3oc2=O)c1F CHEMBL3264000 IC50 81.0 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4ccc(-c5ccccc5)cc4[nH]3)ccnc2N1 CHEMBL3908426 IC50 81.0 nM
O=C(Nc1ccc(Oc2ccnc(-c3ncc(C(F)(F)F)[nH]3)c2)cc1)Nc1ccc(Br)c(F)c1 CHEMBL2047984 IC50 81.5 nM
O=C(Nc1ccc(Oc2cccc(C(=O)NCCN3CCCCC3)c2)cc1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL167894 IC50 82.0 nM
COc1cc2cc(Oc3ccc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)cc3)c(C)nc2cc1OCCN1CCOCC1 CHEMBL5189396 IC50 82.0 nM
Cc1ccc(NC(=O)c2cncnc2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3957922 IC50 83.27 nM
N#Cc1ccc(-c2[nH]c(-c3ccccc3)nc2-c2ccncc2)cc1 CHEMBL307340 IC50 86.0 nM
FC(F)(F)c1ccc2nc(C3C4Oc5ccc(Oc6ccncc6)cc5C43)[nH]c2c1 CHEMBL3922825 IC50 86.0 nM
O=C(Nc1ccc(Oc2ccnc(-c3ncc(C(F)(F)F)[nH]3)c2)cc1)Nc1cccc(C(F)(F)F)c1 CHEMBL2047979 IC50 87.8 nM
O=S(=O)(NCCCNc1nccc(-c2c(-c3ccccc3)nc3sccn23)n1)c1ccc(F)cc1 CHEMBL5086379 IC50 87.8 nM
CCNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(C(F)(F)F)c(Cl)cc3OC)cc2)ccn1 CHEMBL475781 IC50 88.0 nM
O=S(=O)(NCCNc1nccc(-c2c(-c3cccc(F)c3)nc3sccn23)n1)c1ccc(C(F)(F)F)cc1 CHEMBL4780320 IC50 88.4 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3cc(N4CCCCC4)ncn3)c(F)c2)no1 CHEMBL4093023 IC50 89.0 nM
Clc1cccc(-c2nc(-c3ccccc3)[nH]c2-c2ccncc2)c1 CHEMBL401695 IC50 90.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)c3ccc(Cl)c(C(F)(F)F)c3)cc2)ccc1N CHEMBL4542639 IC50 92.0 nM
Cc1cn(-c2cc(NC(=O)c3ccc(C)c(NC(=O)c4cccc5c(N)nccc45)c3)cc(C(F)(F)F)c2)cn1 CHEMBL3980795 IC50 94.8 nM
O=C(Nc1ccc(F)cc1)Nc1ccc(Oc2ccnc(-c3ncc(C(F)(F)F)[nH]3)c2)cc1 CHEMBL2047985 IC50 94.9 nM
COc1cccc(-c2nc3sccn3c2-c2ccnc(NCCCNS(=O)(=O)c3ccc(F)cc3)n2)c1 CHEMBL5093355 IC50 95.2 nM
COc1cc(-c2ccc3nccc(Nc4cc(O)ccc4F)c3c2)ccc1O CHEMBL3661277 IC50 96.1 nM
COc1ccc(S(=O)(=O)NCCCNc2nccc(-c3c(-c4ccccc4)nc4sccn34)n2)cc1 CHEMBL5088456 IC50 98.3 nM
CNc1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2F)ncn1 CHEMBL4097299 IC50 99.0 nM