COCCCn1nc(-c2ccc(CC(=O)Nc3cc(C(C)(C)C)on3)cc2)c2c(N)ncnc21 CHEMBL5429146 IC50 0.0 nM
OC[C@H](Nc1cnc(-c2cc(Cl)ccc2O)c(-c2ccc3cnccc3c2)c1)c1ccccc1 CHEMBL4067871 IC50 0.04 nM
CCOc1cc(-c2ccc(NC(=O)Nc3ccc(CN4CCN(CC)CC4)c(C(F)(F)F)c3)c(F)c2)c[nH]c1=O CHEMBL4218013 IC50 0.1 nM
COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 CHEMBL24828 IC50 0.13 nM
CNC(=O)c1ncc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(CCO)CC4)c(C(F)(F)F)c3)ccc2C)n1C CHEMBL1784637 IC50 0.2 nM
Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(F)ccc3O)cc12 CHEMBL4062877 IC50 0.2 nM
CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(CC(C)(C)N)c(C(F)(F)F)c2)c(F)c1 CHEMBL4218563 IC50 0.2 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1171837 IC50 0.3 nM
COC1(C(=O)N[C@@H](C)c2ccc(-n3cc(F)cn3)nc2)CCC(c2nc(C)cc(Nc3cc(C)[nH]n3)n2)CC1 CHEMBL5171764 IC50 0.3 nM
CO[C@]1(C(=O)N[C@@H](C)c2ccc(-n3cc(F)cn3)nc2)CC[C@H](c2nc(C)cc(Nc3cc(C)[nH]n3)n2)CC1 CHEMBL4582651 IC50 0.3 nM
COc1ccc(CN2[C@@H]3C[C@H]2CN(c2ccc(-c4cc(OCC(C)(C)O)cn5ncc(C#N)c45)cn2)C3)cn1 CHEMBL5430810 Kd 0.3 nM
Cc1cc(Nc2cc(C)[nH]n2)nc(N2CCC3(CCCN([C@@H](C)c4ccc(-n5cc(F)cn5)nc4)C3=O)CC2)n1 CHEMBL4872605 IC50 0.36 nM
Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3ccc(F)cc3O)cc12 CHEMBL4075917 IC50 0.4 nM
CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(CC(C)(C)O)c(C(F)(F)F)c2)c(F)c1 CHEMBL4218127 IC50 0.4 nM
CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(CC(C)(C)CO)c(C(F)(F)F)c2)c(F)c1 CHEMBL4205243 IC50 0.4 nM
CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cc(-c3nnc(C)o3)cc(C(F)(F)F)c2)c(F)c1 CHEMBL4212513 IC50 0.4 nM
CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cc(C(C)(C)C(F)(F)F)no2)c(F)c1 CHEMBL3355010 IC50 0.4 nM
CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cc(C(C)(C)C(F)(F)F)on2)c(F)c1 CHEMBL3355009 IC50 0.4 nM
COc1ccc(CN2C3CC2CN(c2ccc(-c4cc(OCC(C)(C)O)cn5ncc(C#N)c45)cn2)C3)cn1 CHEMBL4559134 IC50 0.4 nM
COc1cc2ncnc(Nc3cc(O)c(F)cc3F)c2cc1OC CHEMBL3775169 IC50 0.41 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.46 nM
CC(=O)N1CCN([C@H]2C[C@@H](n3cc(-c4cc(O)ccc4F)c4c(N)ncnc43)C2)CC1 CHEMBL4854822 IC50 0.54 nM
CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(CC(C)(C)CS(C)(=O)=O)c(C(F)(F)F)c2)c(F)c1 CHEMBL4203429 IC50 0.6 nM
Cc1cc(Nc2cc(C)[nH]n2)nc(N2CCC3(CCCN([C@@H](C)c4cnc(-n5cc(F)cn5)cn4)C3=O)CC2)n1 CHEMBL4870957 IC50 0.61 nM
Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)cncc21 CHEMBL1964692 pKi 0.631 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4ccc(OC(F)F)cc4)cc3)c12 CHEMBL1972220 pKi 0.631 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 0.67 nM
CC(C)(C)c1cc(NC(=O)Cc2ccc(-n3cnc4cc(-c5ccc(S(C)(=O)=O)cc5)ccc43)cc2)no1 CHEMBL4473213 IC50 0.67 nM
Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(Cl)ccc3O)cc12 CHEMBL4105329 IC50 0.7 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(-c4ccc(NC)nc4)cc3)cc2C(F)(F)F)CC1 CHEMBL4205803 IC50 0.7 nM
CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(C(C)C#N)c(C(F)(F)F)c2)c(F)c1 CHEMBL4214146 IC50 0.7 nM
CC(=O)N1CCN([C@H]2C[C@@H](n3cc(-c4ccc(Cl)c(O)c4)c4c(N)ncnc43)C2)CC1 CHEMBL4853155 IC50 0.73 nM
COc1cc2ncnc(Nc3cc(O)c(C)cc3F)c2cc1OC CHEMBL440727 IC50 0.75 nM
CC(C)(N)c1cc(C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688861 IC50 0.8 nM
CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2ccc(CN(C)C)c(C(F)(F)F)c2)c(F)c1 CHEMBL4213626 IC50 0.8 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 0.83 nM
CC(=O)N1CCN([C@H]2C[C@@H](n3cc(-c4ccc(Cl)c(N)c4)c4c(N)ncnc43)C2)CC1 CHEMBL4877264 IC50 0.85 nM
Cc1cc(Nc2cc(C)[nH]n2)nc(C2CCC3(CCCN([C@@H](C)c4ccc(-n5cc(F)cn5)nc4)C3=O)CC2)n1 CHEMBL4845703 IC50 0.9 nM
Cc1cc(Nc2cc(C)[nH]n2)nc(N2CCC3(CC2)OCCN([C@@H](C)c2ccc(-n4cc(F)cn4)nc2)C3=O)n1 CHEMBL4846521 IC50 0.9 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)cc2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687194 IC50 0.95 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)cc2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL4465661 IC50 0.95 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 IC50 1.0 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(O)CO)c5)cnc(N)c34)cc2)cc1 CHEMBL1965170 pKi 1.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CCO)c5)cnc(N)c34)cc2F)c1 CHEMBL1986851 pKi 1.0 nM
CN1CCN(Cc2ccc(NC(=O)CNc3ccc(-c4ccc(NC(=O)C5CC5)nc4)cc3F)cc2C(F)(F)F)CC1 CHEMBL3806189 IC50 1.0 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687202 IC50 1.0 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1N[C@H]1CC[C@](C)(O)CC1 CHEMBL3687212 IC50 1.0 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1NC1CCOCC1 CHEMBL3687215 IC50 1.0 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12 CHEMBL400402 Kd apparent 1.0 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL4466977 IC50 1.0 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1N[C@H]1CC[C@](C)(O)CC1 CHEMBL4438824 IC50 1.0 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1NC1CCOCC1 CHEMBL4580325 IC50 1.0 nM
CO[C@]1(C(=O)N[C@@H](C)c2ccc(-n3cc(F)cn3)nc2)CC[C@@H](c2nc(C)cc(Nc3cc(C)[nH]n3)n2)CC1 CHEMBL4297597 Kd 1.0 nM
COc1cc2ncnc(Nc3cc(O)ccc3F)c2cc1OC CHEMBL3774904 IC50 1.1 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)cc2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687191 IC50 1.1 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1N[C@H]1CC[C@@](C)(O)CC1 CHEMBL3687207 IC50 1.1 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)c(F)c2)nc1NC1CCOCC1 CHEMBL3687222 IC50 1.1 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C4CCN(C)CC4)CC3)c(C)c2)nc1NC1CCOCC1 CHEMBL3687225 IC50 1.1 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)cc2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL4441604 IC50 1.1 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1N[C@H]1CC[C@@](C)(O)CC1 CHEMBL4524842 IC50 1.1 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)c(F)c2)nc1NC1CCOCC1 CHEMBL4461418 IC50 1.1 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C4CCN(C)CC4)CC3)c(C)c2)nc1NC1CCOCC1 CHEMBL4591308 IC50 1.1 nM
Cc1cc(Nc2cc(C)[nH]n2)nc(C2CCC3(CC2)OCCN([C@@H](C)c2ccc(-n4cc(F)cn4)nc2)C3=O)n1 CHEMBL4861957 IC50 1.12 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(-c4ccc(=O)[nH]c4)cc3)cc2C(F)(F)F)CC1 CHEMBL4210670 IC50 1.2 nM
O=C1Nc2ccc(F)cc2/C1=C1/Nc2ccccc2/C1=N\OCCN1CCNCC1 CHEMBL4791998 IC50 1.21 nM
Nc1ncnc2c1c(-c1cnc3[nH]ccc3c1)nn2C1CCCC1 CHEMBL1081312 pKi 1.259 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 1.259 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c2c1CCC/C2=C1/C(=O)Nc2ccc(F)cc21 CHEMBL2180602 IC50 1.3 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C(C)C)CC3)c(C)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687210 IC50 1.3 nM
Cc1cc(Nc2nc(N[C@H]3CC[C@H](O)CC3)c(Cl)nc2C(N)=O)ccc1N1CCC(N2CCN(C)CC2)CC1 CHEMBL3687217 IC50 1.3 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)cc2)nc1NC1CCOCC1 CHEMBL3687220 IC50 1.3 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(C#Cc4cncc(N5CCOCC5)c4)c3)cc2C(F)(F)F)CC1 CHEMBL4091628 IC50 1.3 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C(C)C)CC3)c(C)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL4528166 IC50 1.3 nM
Cc1cc(Nc2nc(N[C@H]3CC[C@H](O)CC3)c(Cl)nc2C(N)=O)ccc1N1CCC(N2CCN(C)CC2)CC1 CHEMBL4580299 IC50 1.3 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)cc2)nc1NC1CCOCC1 CHEMBL4463071 IC50 1.3 nM
CC(C)n1nc(-c2ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)cc2)c2c(N)ncnc21 CHEMBL5178384 IC50 1.3 nM
Cc1cc(Nc2cc(C)[nH]n2)nc(N2CCC3(CCCN([C@@H](C)c4ccc(-n5cc(F)cn5)cc4F)C3=O)CC2)n1 CHEMBL4859281 IC50 1.39 nM
CC(C)n1nc(-c2cc(C3CC3)on2)c2c(N)ncnc21 CHEMBL3753341 IC50 1.4 nM
COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(N)=O CHEMBL1289601 Ki 1.5 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C(F)(F)F)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687200 IC50 1.5 nM
CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)cc2)nc1NC1CCOCC1 CHEMBL3687221 IC50 1.5 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C(F)(F)F)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL4574005 IC50 1.5 nM
CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)cc2)nc1NC1CCOCC1 CHEMBL4483656 IC50 1.5 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1 CHEMBL1946170 IC50 1.5 nM
COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)NC5CC5)CC4)c(Cl)c3)c2cc1C(N)=O CHEMBL5201128 IC50 1.5 nM
COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C(F)(F)F)on4)c3)c2cc1OC CHEMBL2029988 Kd 1.5 nM
Cc1cc(Nc2cc(C)[nH]n2)nc(N2CCC3(CC2)CCN([C@@H](C)c2ccc(-n4cc(F)cn4)nc2)C3=O)n1 CHEMBL4875034 IC50 1.58 nM
CCN(CC)CCCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL1999414 pKi 1.585 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)O)c5)cnc(N)c34)cc2)c1 CHEMBL1989708 pKi 1.585 nM
COC(C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 CHEMBL1981047 pKi 1.585 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCOCC5)ccc34)cc2)no1 CHEMBL576982 Kd 1.6 nM
CN(C)Cc1cc(C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688860 IC50 1.6 nM
CC1(C)c2cc(C3CCN(CC4CCOCC4)CC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3735648 IC50 1.6 nM
COc1cc2ncnc(Nc3c(F)ccc(O)c3F)c2cc1OC CHEMBL3775557 IC50 1.7 nM
CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)cc2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687195 IC50 1.7 nM
CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cccc(C(F)(F)F)c2)c(F)c1 CHEMBL4206308 IC50 1.7 nM
CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)cc2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL4454732 IC50 1.7 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(-c4noc(-c5cncc(-c6cnn(C)c6)c5)n4)c3)cc2C(F)(F)F)CC1 CHEMBL3906151 IC50 1.8 nM
CCc1cc2c(cc1-c1cnn(CCCN(C)C)c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3746678 IC50 2.0 nM
Nc1ncnc2c1c(-c1cc(C3CC3)on1)nn2C1CCCCC1 CHEMBL3753512 IC50 2.0 nM
COc1cc2ncnc(Nc3ccc(F)c(O)c3F)c2cc1OC CHEMBL3775336 IC50 2.0 nM
COC(=O)c1ccc2c(C(Nc3ccc(N(C)C(=O)CN4CCN(C)CC4)cc3)c3ccccc3)c(O)[nH]c2c1 CHEMBL5201102 IC50 2.0 nM
CN(C)CCCOc1ccc(-c2cc(-c3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)n[nH]2)cc1 CHEMBL5417645 Kd 2.0 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(-c4noc(-c5cncc(N6CCOCC6)c5)n4)c3)cc2C(F)(F)F)CC1 CHEMBL3947880 IC50 2.1 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 IC50 2.195 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 2.2 nM
CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C(F)(F)F)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687205 IC50 2.3 nM
CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C(F)(F)F)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL4465573 IC50 2.3 nM
COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC CHEMBL2105717 IC50 2.4 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(C#Cc4cccnc4)c3)cc2C(F)(F)F)CC1 CHEMBL3916184 IC50 2.5 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)cc1C CHEMBL2000335 pKi 2.512 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc32)c1C CHEMBL1990885 pKi 2.512 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 pKi 2.512 nM
COc1cc2ncnc(Nc3cc(O)ccc3Cl)c2cc1OC CHEMBL3774489 IC50 2.6 nM
COc1cc2ncnc(Nc3cc(O)cc(F)c3)c2cc1OC CHEMBL3775934 IC50 2.6 nM
CCOc1cc(=O)[nH]cc1-c1ccc(CC(=O)Nc2cc(C(F)(F)F)cc(CN(C)C)c2F)c(F)c1 CHEMBL4209229 IC50 2.8 nM
CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)cc2)nc1NC1CCOCC1 CHEMBL3687224 IC50 2.9 nM
CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)cc2)nc1NC1CCOCC1 CHEMBL4591953 IC50 2.9 nM
CCN1CCN(c2ccc(Nc3ncc4scc(-c5cccc(NS(C)(=O)=O)c5)c4n3)cc2)CC1 CHEMBL4846921 IC50 2.9 nM
Cc1ccc(O)cc1Nc1ccnc2ccc(S(C)(=O)=O)cc12 CHEMBL237347 IC50 3.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cn4c(n3)sc3ccccc34)cc2)no1 CHEMBL575925 Kd 3.0 nM
CCc1cc2c(cc1-c1cnn(CC(=O)N(C)C)c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3735401 IC50 3.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd apparent 3.0 nM
Nc1nc(Nc2ccc3c(c2)CC[C@@H](N2CCCC2)CC3)nn1-c1cc2c(nn1)-c1ccccc1CCC2 CHEMBL3809489 IC50 3.0 nM
CN1CCN(Cc2ccc(NC(=O)c3cccc(/N=N/c4cnc5[nH]ccc5c4)c3)cc2C(F)(F)F)CC1 CHEMBL5180040 IC50 3.0 nM
Cc1cc(N2CCOCC2)cc2[nH]c(-c3c(NCC(O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL2005886 pKi 3.162 nM
CNC(=O)C(C)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(C)cc5)cc4)csc23)cn1 CHEMBL1970142 pKi 3.162 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 3.162 nM
Cc1cc(=O)[nH]nc1-c1ccc(NC(=O)Nc2cc(C(F)(F)F)ccc2F)c(Cl)c1 CHEMBL1997892 pKi 3.162 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)(C)O)c5)cnc(N)c34)cc2)cc1 CHEMBL2004290 pKi 3.162 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)cc1 CHEMBL1982466 pKi 3.162 nM
Nc1ncc(C=CC(=O)NCCCn2ccnc2)c2scc(-c3ccc(Br)cc3)c12 CHEMBL1994938 pKi 3.162 nM
CCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)csc12 CHEMBL1979516 pKi 3.162 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 3.2 nM
COc1cc2ncnc(Nc3ccc(F)c(O)c3)c2cc1OC CHEMBL3775879 IC50 3.2 nM
CN(C)CCOc1ccc(-c2cc(-c3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)n[nH]2)cc1 CHEMBL5396335 Kd 3.2 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1 CHEMBL3301622 IC50 3.4 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1 CHEMBL4524472 IC50 3.4 nM
C[C@@H](Cc1c(F)c(F)cc(F)c1F)Nc1cc[nH]c(=O)c1-c1nc2cc3c(cc2[nH]1)CN(CCN(C)C)C3=O CHEMBL3671311 IC50 3.527 nM
COc1cc(Nc2nc(NC3CCOCC3)c(C(C)C)nc2C(N)=O)ccc1N1CCN(C)CC1 CHEMBL3687223 IC50 3.6 nM
COc1cc(Nc2nc(NC3CCOCC3)c(C(C)C)nc2C(N)=O)ccc1N1CCN(C)CC1 CHEMBL4438727 IC50 3.6 nM
COc1cc2ncnc(Nc3c(F)ccc(O)c3Cl)c2cc1OC CHEMBL3774953 IC50 3.9 nM
COc1cc2ncnc(Nc3cccc(O)c3O)c2cc1OC CHEMBL3774580 IC50 3.9 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1Oc1nc(-c2cccnc2)nc2[nH]ncc12 CHEMBL4790634 IC50 3.98 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(OC(F)F)cc5)cc4)csc23)cn1 CHEMBL1988387 pKi 3.981 nM
Nc1c(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)cnc2c(-c3ccc4c(c3)OCO4)cnn12 CHEMBL1977134 pKi 3.981 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(-c3c(C)sc4ncnc(N)c34)cc2)c1 CHEMBL371206 pKi 3.981 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 3.981 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 4.0 nM
CC(=O)N1CCc2[nH]c(/C=C3\C(=O)Nc4ccc(C#N)cc43)cc2C1 CHEMBL2403377 IC50 4.0 nM
COc1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCN(C(=O)CCN)C3)C(=O)N2 CHEMBL2403366 IC50 4.0 nM
Cc1ccc(NC(=O)c2ccc(C)c(C(F)(F)F)c2)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12 CHEMBL4798527 IC50 4.0 nM
Nc1ncnc2c1c(-c1cccc(O)c1)cn2C1CCCC1 CHEMBL169390 IC50 4.0 nM
CC(C)(C)n1nc(-c2ccc(NC(=O)c3cc(C(F)(F)F)ccc3F)cc2)c2c(N)ncnc21 CHEMBL5276538 IC50 4.0 nM
CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL4116008 IC50 4.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cc(-c4ccc(OCCCN5CCOCC5)cc4)[nH]n3)cc2)no1 CHEMBL5418899 Kd 4.1 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cc(-c4ccc(OCCN5CCOCC5)cc4)[nH]n3)cc2)no1 CHEMBL5407834 Kd 4.3 nM
O=C1Nc2ccccc2/C1=C1/Nc2ccccc2/C1=N\OCCN1CCNCC1 CHEMBL4781746 IC50 4.42 nM
COc1cc2ncnc(Nc3cccc(O)c3)c2cc1OC CHEMBL127907 IC50 4.5 nM
COc1cc2ncnc(Nc3ccc(C)c(O)c3)c2cc1OC CHEMBL478442 IC50 4.6 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ncccc3O)cc2)no1 CHEMBL1079545 Kd 4.7 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 4.7 nM
COc1cc2ncnc(Nc3c(Cl)ccc(O)c3F)c2cc1OC CHEMBL3775511 IC50 4.8 nM
CCc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL1738797 IC50 4.8 nM
CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL2010872 IC50 5.0 nM
CN1CCC(Nc2ccc3c(c2)/C(=C/c2cc4c([nH]2)CCN(C(=O)N2CCOCC2)C4)C(=O)N3)CC1 CHEMBL2403373 IC50 5.0 nM
Nc1ncnc2c1c(-c1cc(C3CC3)on1)nn2C1CCOCC1 CHEMBL3751904 IC50 5.0 nM
COc1cc2ncnc(Nc3cc(O)c(Cl)cc3Cl)c2cc1OC CHEMBL3775190 IC50 5.0 nM
COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCCN1CCNCC1 CHEMBL3797261 IC50 5.0 nM
CNC(=O)c1cccc2cc(Oc3ccnc4cc(OCC5(N)CC5)c(OC)cc34)ccc12 CHEMBL2220486 Kd apparent 5.0 nM
CC(=O)N1CCN([C@H]2C[C@@H](n3cc(-c4cccc(O)c4)c4c(N)ncnc43)C2)CC1 CHEMBL4848347 IC50 5.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 IC50 5.0 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccc[nH]2)C(=O)N3)c1)Cc1ccccc1 CHEMBL1980407 pKi 5.012 nM
CCN(CC)CCNC(=O)C=Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL2004716 pKi 5.012 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 pKi 5.012 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1979690 pKi 5.012 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Nc3ccc(CC(=O)Nc4ccc(C(C)C)cc4)cc3)n2)[nH]n1 CHEMBL5087283 IC50 5.07 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL1873475 IC50 5.2 nM
Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C1(c2ncnc3[nH]cnc23)CC1 CHEMBL4466555 IC50 5.2 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Nc3ccc(CC(=O)N[C@@H](C)c4ccccc4)cc3)n2)[nH]n1 CHEMBL5074882 IC50 5.45 nM
Cc1nc(Nc2nc3ccc(-c4cccc(C(=O)Nc5cccc(C(F)(F)F)c5)c4)nc3s2)cc(N2CCNCC2)n1 CHEMBL2148120 Kd 5.6 nM
COc1cc(-c2cc(-c3ccc(NC(=O)Nc4cc(C(C)(C)C(F)(F)F)on4)cc3)n[nH]2)ccc1OCCN1CCOCC1 CHEMBL5435683 Kd 5.6 nM
Cc1cc(Nc2cc(N3CCN(CCO)CC3)nc(Nc3ccc(CC(=O)NCc4cccc(F)c4)cc3)n2)[nH]n1 CHEMBL5080296 IC50 5.82 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1336 IC50 5.9 nM
C[C@@H](Cc1c(F)c(F)cc(F)c1F)Nc1cc[nH]c(=O)c1-c1nc2cc3c(cc2[nH]1)CN(C1CCN(C)CC1)C3=O CHEMBL3671309 IC50 5.977 nM
Oc1cccc(Nc2ccnc3cc(-c4ccccn4)ccc23)c1 CHEMBL237344 IC50 6.0 nM
CNC(=O)c1cc(Oc2cccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c2)ccn1 CHEMBL1807196 IC50 6.0 nM
COc1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCN(C(=O)N1CCN(C)CC1)C3)C(=O)N2 CHEMBL2403369 IC50 6.0 nM
CO[C@@H](C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 CHEMBL402548 Kd apparent 6.0 nM
CNc1ncc2c(-c3ccc(N4CCN(C)CC4)cc3)nn(CC3CCCC3)c2n1 CHEMBL4218175 IC50 6.0 nM
COC(=O)Nc1ccc(-c2c(OC3CCN(C)CC3)nc3c(-c4ccc(OC)c(OC)c4)cnn3c2N)cc1 CHEMBL4634073 IC50 6.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cc(-c4cccc(OCCN5CCOCC5)c4)[nH]n3)cc2)no1 CHEMBL5407943 Kd 6.0 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Nc3ccc(CC(=O)NCc4cccc(F)c4)cc3)n2)[nH]n1 CHEMBL5073804 IC50 6.01 nM
COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1 CHEMBL491473 Kd 6.1 nM
COc1cc(-c2cc(-c3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)n[nH]2)ccc1OCCN1CCOCC1 CHEMBL5434393 Kd 6.1 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Nc3ccc(CC(=O)Nc4cccc(F)c4)cc3)n2)[nH]n1 CHEMBL5070593 IC50 6.2 nM
CCN1CCN(c2ccc(Nc3nccc(-c4c(-c5cccc(C(=O)Nc6ccccc6F)c5)nc5ccccn45)n3)cc2)CC1 CHEMBL1981725 pKi 6.31 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Nc3ccc(CC(=O)Nc4ccc(F)cc4)cc3)n2)[nH]n1 CHEMBL5078090 IC50 6.43 nM
CC(C)(c1cc(NC(=O)Nc2ccc(-c3cc(-c4ccc(OCCN5CCOCC5)cc4)[nH]n3)cc2)no1)C(F)(F)F CHEMBL5407194 Kd 6.5 nM
CC(C)(C)c1cc(NC(=O)Cc2ccc(Nc3ncnc4[nH]c(-c5ccc(S(C)(=O)=O)cc5)cc34)cc2)no1 CHEMBL4791960 IC50 6.8 nM
COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCCN(C)C CHEMBL3799523 IC50 7.0 nM
CCN1CCN(Cc2ccc(NC(=O)CNc3ccc(-c4ccc(NC(=O)C5CC5)nc4)cc3)cc2C(F)(F)F)CC1 CHEMBL3805771 IC50 7.0 nM
CN1CCN(c2cc(Nc3cc(C4CC4)n[nH]3)nc(Nc3ccc(CC(=O)NC4CC4)cc3)n2)CC1 CHEMBL5094848 IC50 7.27 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc4ccccc4cn3)cc2)no1 CHEMBL1081509 Kd 7.3 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(-c4noc(-c5cccnc5)n4)c3)cc2C(F)(F)F)CC1 CHEMBL3961612 IC50 7.3 nM
Cc1c2cc(cc1C(=O)Nc1cc(CN3CCN(C)CC3)cc(C3CC3)c1)OCCCCCCCNC(=O)c1ccc3ncc(n3n1)C#C2 CHEMBL5423601 IC50 7.48 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Nc3ccc(CC(=O)NC4CC4)cc3)n2)[nH]n1 CHEMBL5089911 IC50 7.53 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc2c(c1)N(C(=O)CN1CCOCC1)CC2)c1ccccc1 CHEMBL4168811 IC50 7.6 nM
COCC1CN(C2CCN(c3cc(OC)c(Nc4ncc(Br)c(Nc5ccc6c(c5P(C)(C)=O)OCCO6)n4)cc3C)CC2)C1 CHEMBL5188373 IC50 7.8 nM
CN1CCN(Cc2ccc(NC(=O)c3cccc(/C=C/c4cnc5ccccc5c4)c3)cc2C(F)(F)F)CC1 CHEMBL5200675 IC50 7.8 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)ccn1 CHEMBL1992306 pKi 7.943 nM
c1ccc(CNc2nc(Nc3cc(C4CC4)[nH]n3)c3sccc3n2)cc1 CHEMBL1997924 pKi 7.943 nM
CCN(C(C)=O)c1ccc(Nc2nc(NC3CC3)c3nc[nH]c3n2)cc1 CHEMBL2006564 pKi 7.943 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 CHEMBL49120 pKi 7.943 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)c1 CHEMBL196363 pKi 7.943 nM
O=C1Nc2cc(-c3ccc(O)cc3)ccc2C1=Cc1ccc[nH]1 CHEMBL1980329 pKi 7.943 nM
COc1cccc(OC)c1CNc1nc(NC2CCCCC2)nc2ccc(Cl)cc12 CHEMBL1996646 pKi 7.943 nM
COc1ccc(NC(=O)Nc2ccc(-c3cccc4onc(N)c34)cc2)cc1Cl CHEMBL272453 pKi 7.943 nM
CN1CCN(C2CCC(n3cc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1 CHEMBL1997617 pKi 7.943 nM
CC(C)n1nc(C#Cc2ccccc2)c2c(N)ncnc21 CHEMBL2058538 IC50 8.0 nM
Nc1ncnc2c1c(-c1cccc(O)c1)cn2[C@H]1C[C@@H](CN2CCC2)C1 CHEMBL3787112 IC50 8.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cc(-c4ccc(OCCN5CCOCC5)cc4)[nH]n3)cc2F)no1 CHEMBL5410558 Kd 8.1 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cc(-c4ccc(OCCN5CCOCC5)cc4F)[nH]n3)cc2)no1 CHEMBL5416730 Kd 8.3 nM
Cc1cc(Nc2cc(N3CCN(CCN4CCOCC4)CC3)nc(Nc3ccc(CC(=O)NC4CC4)cc3)n2)[nH]n1 CHEMBL5093057 IC50 8.31 nM
COc1cc2ncnc(Nc3cc(O)ccc3C)c2cc1OC CHEMBL3774951 IC50 8.4 nM
Cn1cc(-c2nc(N[C@@H]3CCCC[C@@H]3N)c(F)c3c2C(=O)NC3)cn1 CHEMBL3979920 IC50 8.4 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL572878 Kd 8.6 nM
COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCCN1CCS(=O)(=O)CC1 CHEMBL3798584 IC50 9.0 nM
CC(C)c1cc(CNc2nc(Nc3cc(C4CC4)[nH]n3)cc(N3CCN(C)CC3)n2)on1 CHEMBL3545085 Kd apparent 9.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCCN4)cc2)no1 CHEMBL4793380 IC50 9.0 nM
Cn1cc(-c2cc3c(Nc4ccc(CC(=O)Nc5cc(C(C)(C)C)on5)cc4)ncnc3[nH]2)cn1 CHEMBL4784249 IC50 9.0 nM
Cn1nc(C(C)(C)C)cc1NC(=O)Cc1ccc(Nc2ncnc3[nH]c(-c4ccc(S(C)(=O)=O)cc4)cc23)cc1 CHEMBL4794965 IC50 9.0 nM
CC(=O)N1CCN([C@H]2C[C@@H](n3cc(-c4ccc(O)cc4)c4c(N)ncnc43)C2)CC1 CHEMBL4855562 IC50 9.0 nM
COc1cc(-c2cc(-c3ccc(NC(=O)Nc4cc(C(C)(C)C(F)(F)F)on4)c(F)c3)n[nH]2)ccc1OCCN1CCOCC1 CHEMBL5417348 Kd 9.0 nM
CN1CCN(c2ccc(Nc3ncc4cc(C#N)c(=O)n(C5CCCC5)c4n3)cc2)CC1 CHEMBL3115681 IC50 9.2 nM
COc1cc2ncnc(Nc3ccc(C)c(O)c3Cl)c2cc1OC CHEMBL3775560 IC50 9.3 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cc(-c4ccc(OCCN5CCOCC5)c(Cl)c4)[nH]n3)cc2)no1 CHEMBL5409032 Kd 9.4 nM
CN1CCN(Cc2ccc(NC(=O)c3cccc(/N=N/c4cnc5ccccc5c4)c3)cc2C(F)(F)F)CC1 CHEMBL5189744 IC50 9.5 nM
COc1cc2ncnc(Nc3c(Cl)ccc(O)c3Cl)c2cc1OC CHEMBL3775585 IC50 9.7 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cc(-c4ccc(OCCN5CCOCC5)c(F)c4)[nH]n3)cc2)no1 CHEMBL5409897 Kd 9.7 nM
CN1CCN(Cc2ccc(NC(=O)[C@@H]3CCN(c4ccc5ncc(-c6ccccn6)n5n4)C3)cc2C(F)(F)F)CC1 CHEMBL5421783 IC50 9.9 nM
Nc1ncnc2onc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)c12 CHEMBL213505 pKi 10.0 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1998585 pKi 10.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cnc4c(-c5cnn(C)c5)cnn4c3N)cc2)c1 CHEMBL508928 pKi 10.0 nM
Cc1ccc(-c2nn(C(C)(C)C)c3ncnc(N)c23)cc1 CHEMBL306380 pKi 10.0 nM
O=C1NN=Cc2c[nH]c3cc(NC(=O)C4CC4c4ccccc4)cc1c23 CHEMBL1969502 pKi 10.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN(C)C)cnc(N)c34)cc2)c1 CHEMBL1979883 pKi 10.0 nM
CCN1CCN(c2ccc(Nc3ncc(C#N)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1973516 pKi 10.0 nM
O=C(Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCCC4=O)c3)n2)c1)c1c(F)cccc1F CHEMBL2006715 pKi 10.0 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(C=Cc3ccccc3)n2)n[nH]1 CHEMBL1983923 pKi 10.0 nM
Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c12 CHEMBL1976220 pKi 10.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)c2cc1OC CHEMBL2031893 IC50 10.0 nM
CNc1cc2ccc(C#CCOc3ccc(CN4CCNCC4)c(C(F)(F)F)c3)cc2cn1 CHEMBL3355065 IC50 10.0 nM
COc1cc2ncnc(Nc3ccc(Cl)c(O)c3)c2cc1OC CHEMBL235851 IC50 10.0 nM
COc1cc2ncnc(Nc3cccc(O)c3F)c2cc1OC CHEMBL3775903 IC50 10.0 nM
Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)ccc2C)n(C)n1 CHEMBL2180604 Kd apparent 10.0 nM
Cn1cc(C2=Nc3cc(NC(=O)C(N)C4CCCCC4)cc4c3C2=CNNC4=O)cn1 CHEMBL3545137 Kd apparent 10.0 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(/C=C/c3ccccc3)n2)n[nH]1 CHEMBL482968 IC50 10.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCN4)cc2F)no1 CHEMBL4789515 IC50 10.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCN4)cc2)no1 CHEMBL4779887 IC50 10.0 nM
CC(C)n1nc(-c2cc(CO)on2)c2c(N)ncnc21 CHEMBL4088300 IC50 10.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3n[nH]c(-c4ccc(OCCN5CCOCC5)cc4Cl)n3)cc2)no1 CHEMBL5401715 Kd 10.2 nM
COc1cc(-c2cc(-c3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)c(F)c3)n[nH]2)ccc1OCCN1CCOCC1 CHEMBL5417096 Kd 10.2 nM
CN1CCN(c2cc(Nc3cc(C4CC4)n[nH]3)nc(Nc3ccc(CC(=O)NCc4cccc(F)c4)cc3)n2)CC1 CHEMBL5085579 IC50 10.52 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)NC4CCCCCCC4)cc3)c2cc1C(N)=O CHEMBL5279334 IC50 10.7 nM
COc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1O CHEMBL3774563 IC50 11.0 nM
COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCCN1CCOCC1 CHEMBL3799933 IC50 11.0 nM
COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCCN1CCCNCC1 CHEMBL3799971 IC50 11.0 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(F)c(/N=N/c4cnc5ccccc5c4)c3F)cc2C(F)(F)F)CC1 CHEMBL5184072 IC50 11.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cc(-c4ccc(OCCN5CCOCC5)cc4Cl)[nH]n3)cc2)no1 CHEMBL5394257 Kd 11.0 nM
NC(=O)c1c(OCc2c(F)cc(Br)cc2F)nsc1NC(=O)NCCCCN1CCCC1 CHEMBL253969 IC50 11.1 nM
Cc1c2c(cc3[nH]c(-c4c(NC(C)Cc5c(F)c(F)cc(F)c5F)cc[nH]c4=O)nc13)C(=O)N(C1CCN(C)CC1)C2 CHEMBL3671320 IC50 11.15 nM
Cn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(Nc2ccc(Oc3ccnc4cc(OCCN5CCOCC5)c(C(N)=O)cc34)c(F)c2)n1 CHEMBL5268831 IC50 11.2 nM
COCCOc1cncc(-c2nc(-c3cc(C(=O)Nc4ccc(CN5CCN(C)CC5)c(C(F)(F)F)c4)ccc3Cl)no2)c1 CHEMBL3987007 IC50 11.4 nM
COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCc1cccnc1 CHEMBL3800346 IC50 12.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC CHEMBL1289494 Kd apparent 12.0 nM
Cn1cc(C(=O)NC23CC4CC(CC(C4)C2)C3)c(Nc2ccc(Oc3ccnc4cc(OCCCN5CCOCC5)c(C(N)=O)cc34)c(F)c2)n1 CHEMBL5284144 IC50 12.0 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(-c4nc(-c5cccnc5)no4)c3)cc2C(F)(F)F)CC1 CHEMBL3985315 IC50 12.4 nM
COc1c(/C=C/c2cccc(C(=O)Nc3ccc(CN4CCN(C)CC4)c(C(F)(F)F)c3)c2)cnc2ccccc12 CHEMBL5179230 IC50 12.4 nM
CCN1CCN(c2cc(Nc3cc(C)n[nH]3)nc(Nc3ccc(CC(=O)NCc4cccc(F)c4)cc3)n2)CC1 CHEMBL5094196 IC50 12.41 nM
Cc1cc(OCCN2CCOCC2)ccc1-c1cc(-c2ccc(NC(=O)Nc3cc(C(C)(C)C)on3)cc2)n[nH]1 CHEMBL5434967 Kd 12.5 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 12.59 nM
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1973540 pKi 12.59 nM
O=C(Cc1ccccc1)Nc1cc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCOCC4)c3)n2)ccc1Cl CHEMBL2005482 pKi 12.59 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4c3CNC4=O)cc2C)c1 CHEMBL183844 pKi 12.59 nM
COc1cc2c(cc1F)C(c1ccccc1Cl)=Nc1c(n[nH]c1C)N2 CHEMBL1980391 pKi 12.59 nM
COc1cc2ncnc(Nc3cc(O)c(C)cc3Cl)c2cc1OC CHEMBL3775415 IC50 13.0 nM
CC(Cc1cc(F)ccc1F)Nc1cc[nH]c(=O)c1-c1nc2cc3c(cc2[nH]1)C(=O)N(CCN(C)C)C3 CHEMBL3671318 IC50 13.07 nM
Cc1cc(Nc2cc(-c3cnn(CCN(C)C)c3)nc(Nc3ccc(CC(=O)Nc4ccccc4F)cc3)n2)[nH]n1 CHEMBL5089027 IC50 13.09 nM
CCN1CCN(c2cc(Nc3cc(C)n[nH]3)nc(Nc3ccc(CC(=O)NCc4ccc(OC)cc4)cc3)n2)CC1 CHEMBL5086966 IC50 13.45 nM
Cc1cc(Nc2nc(N3CCC4(CC3)OCCN([C@@H](C)c3ccc(-n5cc(F)cn5)nc3)C4=O)ncc2F)n[nH]1 CHEMBL4862303 IC50 13.5 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)NC45CC6CC(CC(C6)C4)C5)c(F)c3)c2cc1C(N)=O CHEMBL5291008 IC50 13.7 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)NC45CCC(CC4)CC5)cc3)c2cc1C(N)=O CHEMBL5280596 IC50 13.8 nM
CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc21 CHEMBL572881 Kd 14.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 14.0 nM
COCCOc1cc2ncnc(Nc3c(F)ccc(O)c3C)c2cc1OC CHEMBL3797413 IC50 14.0 nM
COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCN1CCS(=O)(=O)CC1 CHEMBL3797561 IC50 14.0 nM
COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCN1CCOCC1 CHEMBL3797688 IC50 14.0 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)NC45CC6CC(CC(C6)C4)C5)c(C#N)c3)c2cc1C(N)=O CHEMBL5270601 IC50 14.7 nM
O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1ccccc1 CHEMBL2380845 IC50 15.0 nM
COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCCN1CCCCC1 CHEMBL3799244 IC50 15.0 nM
COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCCN1CCCC1 CHEMBL3800542 IC50 15.0 nM
CN1CCN(Cc2ccc(NC(=O)c3cccc(/N=N\c4cnc5ccccc5c4)c3)cc2C(F)(F)F)CC1 CHEMBL5200720 IC50 15.0 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)NC45CC6CC(CC(C6)C4)C5)cc3)c2cc1C(N)=O CHEMBL5284208 IC50 15.5 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cc(-c4ccc(OCCN5CCOCC5)cc4Br)[nH]n3)cc2)no1 CHEMBL5400853 Kd 15.5 nM
CCN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1967998 pKi 15.85 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3coc4c(C#CCN5CCOCC5)cnc(N)c34)cc2)c1 CHEMBL1983640 pKi 15.85 nM
CC(C)(c1cc(Br)c(O)c(I)c1)c1cc(Br)c(O)c(I)c1 CHEMBL1964382 pKi 15.85 nM
Cc1cccc(NC(=O)Nc2ccc(-c3coc4ncnc(N)c34)cc2)c1 CHEMBL1983963 pKi 15.85 nM
COc1ccc(-c2ccc(NC(=O)Nc3cccc(Br)c3)cc2)c2c(N)noc12 CHEMBL271381 pKi 15.85 nM
Cc1cc(Nc2cc(N3CCN(CCN4CCOCC4)CC3)nc(Nc3ccc(CC(=O)Nc4ccc(C(C)C)cc4)cc3)n2)[nH]n1 CHEMBL5079216 IC50 15.87 nM
COc1cc2ncnc(Oc3cccc(O)c3)c2cc1OC CHEMBL3775672 IC50 16.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cc(-c4ccc(OCCN5CCOCC5)cc4)[nH]n3)c(Cl)c2)no1 CHEMBL5403376 Kd 16.0 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)NC45CC6CC(CC(C6)C4)C5)c(Cl)c3)c2cc1C(N)=O CHEMBL5269214 IC50 16.4 nM
COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCN1CCNCC1 CHEMBL3798033 IC50 17.0 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 IC50 17.0 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(F)c(/N=N\c4cnc5ccccc5c4)c3F)cc2C(F)(F)F)CC1 CHEMBL5185302 IC50 17.0 nM
Cc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1995703 IC50 17.0 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)NC4CCCCC4)cc3)c2cc1C(N)=O CHEMBL5275850 IC50 17.2 nM
CN1CCN(Cc2ccc(NC(=O)c3cccc(-c4noc(-c5cccnc5)n4)c3)cc2C(F)(F)F)CC1 CHEMBL3943036 IC50 17.9 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1NC(=O)CCN1CCN(C)CC1 CHEMBL3288854 Ki 18.0 nM
COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCC1CCCO1 CHEMBL3800155 IC50 18.0 nM
Cc1cc(NC(=O)Nc2cc(C(C)(C)C)on2)ccc1-c1cc(-c2ccc(OCCN3CCOCC3)cc2)[nH]n1 CHEMBL5395057 Kd 18.0 nM
Cc1cc(Nc2cc(-c3cnn(CCN(C)C)c3)nc(Nc3ccc(CC(=O)Nc4cccc(F)c4)cc3)n2)[nH]n1 CHEMBL5092920 IC50 18.77 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)c(C#N)cc2F)n[nH]1 CHEMBL1774056 IC50 19.0 nM
COc1cc2ncnc(Nc3cccc(O)c3Cl)c2cc1OC CHEMBL3775840 IC50 19.0 nM
CN(C)CCCNc1ccn2ncc(-c3ccc4c(c3)OCO4)c2n1 CHEMBL4561280 IC50 19.0 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(-c4cnc(-c5cccnc5)o4)c3)cc2C(F)(F)F)CC1 CHEMBL3952889 IC50 19.4 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C(C)C(=O)N(C)C)c5)cnc(N)c34)cc2)cc1 CHEMBL2001485 pKi 19.95 nM
Cc1ccc(NC(=O)Nc2ccc(-c3cccc4c3CNC4=O)cc2)cc1C CHEMBL184847 pKi 19.95 nM
CCc1cccc(NC(=O)Nc2ccc3c(c2)CCc2sc4ncnc(N)c4c2-3)c1 CHEMBL1968406 pKi 19.95 nM
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCCC4=O)c3)n2)c1 CHEMBL1991429 pKi 19.95 nM
CNC(=O)C=Cc1cnc(N)c2c(-c3ccc4c(c3)OCO4)csc12 CHEMBL1993243 pKi 19.95 nM
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCOCC4)c3)n2)c1 CHEMBL1090360 pKi 19.95 nM
CC(=O)OCCn1nc(-c2cccc(Br)c2)c2c(C(F)(F)F)cc(=O)[nH]c21 CHEMBL1984847 pKi 19.95 nM
CNC(=O)C=Cc1cnc(N)c2c(-c3ccc4sc(C)nc4c3)csc12 CHEMBL1968590 pKi 19.95 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 19.95 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 20.0 nM
N[C@H]1CCCC[C@H]1Nc1cc2nc[nH]c(=O)c2c(Nc2cccc3cc[nH]c23)n1 CHEMBL3262356 IC50 20.0 nM
NC(=O)c1ccc(-c2cnn3ccc(NCc4ccncc4)nc23)cc1 CHEMBL4534366 IC50 20.0 nM
Nc1ncnc2scc(-c3ccc4c(C(=O)Nc5ccccc5)cccc4c3)c12 CHEMBL3288526 IC50 20.2 nM
C=CC(=O)N[C@@H]1Cn2c(c(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1=C CHEMBL4211949 IC50 20.3 nM
COc1cc2ncnc(Nc3cc(F)cc(O)c3C)c2cc1OC CHEMBL3774913 IC50 21.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCN4)c(F)c2)no1 CHEMBL4784865 IC50 21.0 nM
Cn1cc(-c2cc3c(Nc4ccc(CC(=O)Nc5cc(C(C)(C)C)nn5C)cc4)ncnc3[nH]2)cn1 CHEMBL4789906 IC50 21.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cc(-c4ccc(OCCN5CCOCC5)cc4)[nH]n3)cc2Cl)no1 CHEMBL5440825 Kd 21.0 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(-c4nc(-c5cccnc5)co4)c3)cc2C(F)(F)F)CC1 CHEMBL3925190 IC50 21.4 nM
COc1cc(NC(=O)Nc2cc(C(C)(C)C)on2)ccc1Nc1ncnc2c1OCCN2 CHEMBL4784000 IC50 22.0 nM
Cc1cc(Nc2cc(N3CCN(CCO)CC3)nc(Nc3ccc(CC(=O)NC4CC4)cc3)n2)[nH]n1 CHEMBL5075257 IC50 22.1 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(-c4ccnc(NC)c4)cc3)cc2C(F)(F)F)CC1 CHEMBL4215099 IC50 22.2 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5cccc(F)c5)cccc4c3)n2)c1 CHEMBL3740487 IC50 22.8 nM
COc1cc2ncnc(Sc3cccc(O)c3)c2cc1OC CHEMBL3775376 IC50 23.0 nM
COc1cc2ncnc(Nc3cccc(O)c3Br)c2cc1OC CHEMBL3775164 IC50 23.0 nM
CNCCCOc1cc2ncnc(Nc3c(F)ccc(O)c3C)c2cc1OC CHEMBL3799756 IC50 23.0 nM
NC(=O)Nc1cc(-c2cccc(F)c2)sc1C(=O)N[C@H]1CCCNC1 CHEMBL2041933 Kd apparent 23.0 nM
COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCc1noc(C)n1 CHEMBL3798119 IC50 24.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn(-c4ccc(OCCN5CCOCC5)cc4Cl)nn3)cc2)no1 CHEMBL4645320 Kd 24.0 nM
COc1c(/N=N/c2cccc(C(=O)Nc3ccc(CN4CCN(C)CC4)c(C(F)(F)F)c3)c2)cnc2ccccc12 CHEMBL5191715 IC50 24.0 nM
CC(C)c1ccc(NC(=O)Cc2ccc(Nc3nc(Nc4cc(C5CC5)n[nH]4)cc(N4CCN(C)CC4)n3)cc2)cc1 CHEMBL5087974 IC50 24.7 nM
OCc1nc(-c2ccc3c(Nc4cc(O)c(F)cc4Cl)ccnc3c2)cs1 CHEMBL237128 IC50 25.0 nM
Cc1ccc(O)cc1Nc1ccnc2cc(-c3csc(C=O)n3)ccc12 CHEMBL237127 IC50 25.0 nM
CC(=O)Nc1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCN(C(=O)N1CCOCC1)C3)C(=O)N2 CHEMBL2403374 IC50 25.0 nM
COc1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCN(C(=O)N1CCOCC1)C3)C(=O)N2 CHEMBL2403370 IC50 25.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCN4)c(O)c2)no1 CHEMBL4797687 IC50 25.0 nM
CO[C@H](C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 CHEMBL384575 IC50 25.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN5CCCC5)cnc(N)c34)cc2)c1 CHEMBL1973211 pKi 25.12 nM
Cc1ccc(NC(=O)Nc2ccc(-c3coc4ncnc(N)c34)cc2)cc1 CHEMBL2005828 pKi 25.12 nM
CNCC#Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL1964441 pKi 25.12 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 25.12 nM
Nc1ncc(-c2ccoc2)c2scc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)c12 CHEMBL1965570 pKi 25.12 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4c3CNC4=O)cc2)c1 CHEMBL185569 pKi 25.12 nM
C[C@@H](Cc1c(F)c(F)cc(F)c1F)Nc1cc[nH]c(=O)c1-c1nc2cc3c(cc2[nH]1)C(=O)N(CCN(C)C)C3=O CHEMBL3671310 IC50 25.82 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(-c4noc(-c5ccncc5)n4)c3)cc2C(F)(F)F)CC1 CHEMBL3913553 IC50 26.6 nM
Cn1nc(-c2cc(C3CC3)on2)c2c(N)ncnc21 CHEMBL3752118 IC50 27.0 nM
CCOc1cc(N2CCN(C)CC2)ccc1Nc1ncc2cc(-c3cccc(NC(=O)c4cccc(C(F)(F)F)c4)c3)c(=O)n(C[C@H]3CCCO3)c2n1 CHEMBL5415503 IC50 27.7 nM
CCN1CCN(CCCOc2cc3nccc(Oc4c(F)cc(NC(=O)NN5C(=O)CSC5c5ccc(F)cc5F)cc4F)c3cc2OC)CC1 CHEMBL5409449 IC50 27.9 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 28.0 nM
Cc1cc(Nc2cc(-c3cnn(CCN(C)C)c3)nc(Nc3ccc(CC(=O)Nc4ccc(C(C)C)cc4)cc3)n2)[nH]n1 CHEMBL5081199 IC50 28.11 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)NCC4CCCCC4)cc3)c2cc1C(N)=O CHEMBL5272928 IC50 28.3 nM
COc1cc2ncnc(Nc3cc(C)cc(O)c3)c2cc1OC CHEMBL3775086 IC50 29.0 nM
COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCCN1CCN(C)CC1 CHEMBL3800348 IC50 29.0 nM
COc1cc(CCc2cc(NC(=O)c3ccc(N4CC(C)NC(C)C4)cc3)n[nH]2)cc(OC)c1 CHEMBL3184679 Kd apparent 29.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 CHEMBL103667 IC50 30.0 nM
COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCN1CCC(F)C1 CHEMBL3800250 IC50 30.0 nM
O=C(Nc1cccc(C(F)(F)F)c1)c1cccc2cc(Oc3cc(CO)ncn3)ccc12 CHEMBL4080062 IC50 30.0 nM
Nc1nccc(Oc2ccc3c(C(=O)Nc4cccc(C(F)(F)F)c4)cccc3c2)n1 CHEMBL4104297 IC50 30.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3c[nH]c(-c4ccc(OCCN5CCOCC5)cc4Cl)n3)cc2)no1 CHEMBL5407466 Kd 31.5 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(-c4ccccc4)c3n2)c1 CHEMBL1988163 pKi 31.62 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCCCCCCCCN)cnc(N)c34)cc2)c1 CHEMBL1978166 pKi 31.62 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1970317 pKi 31.62 nM
COc1ccc(CN(C)C)cc1Nc1nccc(-c2c(-c3cccc(NC(=O)c4c(F)cccc4F)c3)nc3sccn23)n1 CHEMBL1997051 pKi 31.62 nM
Cc1cc(C)c(C=C2C(=O)Nc3ccccc32)[nH]1 CHEMBL2002702 pKi 31.62 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccccc1 CHEMBL1999931 pKi 31.62 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-n3nc(-c4ccc(OCCN5CCOCC5)cc4)c4c(N)ncnc43)cc2)no1 CHEMBL4101411 IC50 32.0 nM
COc1cc(NC(=O)Nc2cc(C(C)(C)C)on2)ccc1-c1cc(-c2ccc(OCCN3CCOCC3)cc2)[nH]n1 CHEMBL5420863 Kd 32.0 nM
Cc1ccc(O)cc1Nc1ccnc2cc(-c3csc(CN4CCOCC4)n3)c(S(C)(=O)=O)cc12 CHEMBL399208 IC50 34.0 nM
COc1ccc2c(c1)/C(=C/c1[nH]c3c(c1Cl)CN(C(C)=O)CC3)C(=O)N2 CHEMBL2403371 IC50 34.0 nM
COc1cccc(Nc2ncnn3ccc(CN4CC[C@@H](N)[C@H](O)C4)c23)c1 CHEMBL3545396 Kd apparent 34.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Cc4ccc(Cl)c(C(F)(F)F)c4)cc3)c2cc1OC CHEMBL4577779 IC50 34.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 35.0 nM
CCCNCc1cncc(-c2cnc3[nH]nc(-c4nc5cc(OC)ccc5[nH]4)c3c2)c1 CHEMBL1807197 IC50 36.0 nM
CCCCNCc1cncc(-c2cnc3[nH]nc(-c4nc5cc(OC)ccc5[nH]4)c3c2)c1 CHEMBL1807521 IC50 38.0 nM
COCCCOc1cc2ncnc(Nc3c(F)ccc(O)c3C)c2cc1OC CHEMBL3797684 IC50 38.0 nM
CCNCc1cncc(-c2cnc3[nH]nc(-c4nc5cc(F)c(F)cc5[nH]4)c3c2)c1 CHEMBL248712 IC50 39.0 nM
c1ccc(CNc2ccn3ncc(-c4ccc5c(c4)OCO5)c3n2)nc1 CHEMBL4458622 IC50 39.0 nM
Cn1cc(-c2[nH]c3cc(NC(=O)[C@H](N)C4CCCCC4)cc4c3c2C=NNC4=O)cn1 CHEMBL3990456 IC50 39.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3nsc4ncnc(N)c34)cc2)c1 CHEMBL262433 pKi 39.81 nM
CC(C)Oc1cc(Nc2nc(NC(C)c3ccc(F)cn3)ncc2Cl)n[nH]1 CHEMBL2007421 pKi 39.81 nM
CN1CCN(c2ccc(C(=O)Nc3n[nH]c4ccc(Cc5cc(F)cc(F)c5)cc34)c(NC3CCOCC3)c2)CC1 CHEMBL1983268 pKi 39.81 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 pKi 39.81 nM
O=C(NN=Cc1ccc(O)cc1O)Nc1cccc2nsnc12 CHEMBL1999811 pKi 39.81 nM
CCN(CC)CCCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)csc12 CHEMBL1996649 pKi 39.81 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 40.0 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)NC45CC6CC(CC(C6)C4)C5)c(C)c3)c2cc1C(N)=O CHEMBL5279026 IC50 40.5 nM
CC(C)c1cc(-c2nn(C(C)C)c3ncnc(N)c23)no1 CHEMBL3752395 IC50 41.0 nM
CCc1cc(-c2nn(C(C)C)c3ncnc(N)c23)no1 CHEMBL3753958 IC50 41.0 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Nc3ccc(CC(=O)N[C@H](C)c4ccccc4)cc3)n2)[nH]n1 CHEMBL5084023 IC50 41.29 nM
CC(C)n1nc(C#Cc2ccc(F)cc2)c2c(N)ncnc21 CHEMBL2058539 IC50 43.0 nM
COc1cc2ncnc(Nc3c(F)ccc(O)c3C)c2cc1OC CHEMBL3775940 IC50 44.0 nM
COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCN1CCN(C)CC1 CHEMBL3798442 IC50 44.0 nM
CC(C)n1nc(-c2cc(C3CC3)on2)c(C(N)=O)c1N CHEMBL4090213 IC50 44.0 nM
NC(=O)c1ccc(-c2cnn3ccc(NCc4ccccn4)nc23)cc1 CHEMBL4468733 IC50 44.0 nM
Cc1cc(NC(=O)Nc2cc(C(C)(C)C)on2)ccc1Nc1ncnc2c1OCCN2 CHEMBL4798046 IC50 44.0 nM
CC(=O)c1ccc(-c2cc3c(Nc4ccc(CC(=O)Nc5cc(C(C)(C)C)on5)cc4)ncnc3[nH]2)cc1 CHEMBL4794686 IC50 44.0 nM
COc1cc(Oc2ccnc3cc(OC)c(C(N)=O)cc23)ccc1Nc1nn(C)cc1C(=O)NC12CC3CC(CC(C3)C1)C2 CHEMBL5287259 IC50 45.9 nM
C[C@H](Nc1nc(Nc2cn(C)cn2)c2cc[nH]c2n1)c1ncc(F)cn1 CHEMBL3116050 IC50 46.0 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1ccc(C(=O)NO)cc1 CHEMBL5408198 IC50 47.0 nM
COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCCN CHEMBL3798215 IC50 48.0 nM
COc1cc2c(cc1OC)/C(=C\c1ccc(NC(=O)Nc3ccc(O)cc3)cc1)C(=O)N2 CHEMBL396098 IC50 50.0 nM
CC(C)n1nc(/C=C/c2ccccc2)c2c(N)ncnc21 CHEMBL2058543 IC50 50.0 nM
CNc1ncc2c(-c3ccc(N4CCNCC4)nc3)nn(CC3CCCC3)c2n1 CHEMBL4213003 IC50 50.0 nM
CC(C)(C)c1cc(NC(=O)Cc2ccc(Nc3ncnc4[nH]c(-c5ccsc5)cc34)cc2)no1 CHEMBL4778228 IC50 50.0 nM
COc1cc2c(Nc3ccc(NC(=O)c4ccccc4)cc3)ncnc2cc1OCCCN1CCOCC1 CHEMBL202721 pKi 50.12 nM
CC(C)(C)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1970104 pKi 50.12 nM
Cc1cc(=O)n2ccc(CN(C)C)c(O)c2n1 CHEMBL1988581 pKi 50.12 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4ccnc(N)c34)cc2)c1 CHEMBL394619 pKi 50.12 nM
Nc1ccc(-c2csc3c(C=Cc4nc5ccccc5[nH]4)cnc(N)c23)cc1 CHEMBL1988300 pKi 50.12 nM
Cn1cc(C=C2C(=O)Nc3cccnc32)c2ccccc21 CHEMBL1516890 pKi 50.12 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 50.12 nM
Cc1cccc(NC(=O)Nc2ccc3c(c2)CCc2sc4ncnc(N)c4c2-3)c1 CHEMBL1242373 pKi 50.12 nM
Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12 CHEMBL394790 pKi 50.12 nM
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)c1 CHEMBL1090356 pKi 50.12 nM
N#Cc1ccc2nc(N)n(-c3nc(-c4ccccc4)cs3)c2c1 CHEMBL1996066 pKi 50.12 nM
NC(=O)c1ccc(-c2cnn3ccc(NCc4cccnc4)nc23)cc1 CHEMBL4570029 IC50 51.0 nM
Nc1ncnc2c1c(-c1cccc(O)c1)cn2[C@H]1C[C@@H](CO)C1 CHEMBL4858720 IC50 51.0 nM
Nc1ncnc2[nH]nc(-c3cc(C4CC4)on3)c12 CHEMBL3752879 IC50 52.0 nM
Cn1nc(C(C)(C)C)cc1NC(=O)Cc1ccc(Nc2ncnc3[nH]c(-c4ccsc4)cc23)cc1 CHEMBL4778453 IC50 52.0 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 53.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL223360 Kd 54.0 nM
COc1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCN(C(C)=O)C3)C(=O)N2 CHEMBL2403367 IC50 54.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 54.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCN4)nc2)no1 CHEMBL4794949 IC50 54.0 nM
C[C@@H](Nc1ccc2[nH]nc(/C=C/c3ccccn3)c2c1)c1cc(F)cc(F)c1 CHEMBL4792981 Kd 55.0 nM
CC(C)(C)c1cc(NC(=O)Nc2cccc(Oc3cncc(-c4ccc(F)cc4)n3)c2)no1 CHEMBL3596889 IC50 56.0 nM
COc1cccc2cc(-c3nc([C@H]4CC[C@H](C(=O)O)CC4)n4ncnc(N)c34)[nH]c12 CHEMBL3120215 Kd apparent 57.0 nM
CS(=O)(=O)Cc1cccc(Nc2nccc(Oc3ccc4c(C(=O)Nc5ccccc5)cccc4c3)n2)c1 CHEMBL3740721 IC50 59.2 nM
COc1cc2c3c(-c4ccc(O)cc4)c[nH]c(=O)c3n(C)c2cc1OC CHEMBL461340 IC50 60.0 nM
COc1cc2ncnc(N3CCc4c(O)cccc43)c2cc1OC CHEMBL3774430 IC50 60.0 nM
CNc1ncc2c(-c3ccc(N4CCN(C)CC4)nc3)nn(CC3CCCC3)c2n1 CHEMBL4208852 IC50 60.0 nM
CC(O)c1cc(-c2nn(C(C)C)c3ncnc(N)c23)no1 CHEMBL4096031 IC50 61.2 nM
COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCCN1CCCC1C(F)(F)F CHEMBL3798883 IC50 62.0 nM
CCc1ccc(C#Cc2c3n(c4ncnc(N)c24)C(C)CC3)cc1 CHEMBL4063276 IC50 62.5 nM
Cn1cc(-c2cncc(-c3ccc(NC(=O)Nc4cc(C(C)(C)C)no4)cc3)n2)cn1 CHEMBL3596892 IC50 63.0 nM
Cc1cc(NC(=O)Cc2ccc(-c3cccc4[nH]nc(N)c34)cc2)ccc1F CHEMBL1984363 pKi 63.1 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 pKi 63.1 nM
CCOc1ccccc1-c1cccc(-c2n[nH]c3nc(O)cc(C)c23)c1 CHEMBL1983070 pKi 63.1 nM
Cc1ccccc1Nc1nccc(-c2c(-c3cccc(NC(=O)c4ccccc4)c3)nc3sccn23)n1 CHEMBL1988076 pKi 63.1 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 63.1 nM
Nc1c(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)ccc2nccnc12 CHEMBL2004438 pKi 63.1 nM
Cc1[nH]c(C=C2C(=O)Nc3ccccc32)c(C)c1CCC(=O)O CHEMBL2007064 pKi 63.1 nM
COc1ccc(-c2ccc(NC(=O)Nc3ccc(F)c(C)c3)cc2)c2c(N)noc12 CHEMBL1979093 pKi 63.1 nM
CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1 CHEMBL2006765 pKi 63.1 nM
Cc1cc(OCC2CCC(C(=O)O)C2)c(NC(=O)Nc2cnc(C#N)cn2)cc1Cl CHEMBL1991285 pKi 63.1 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(O)c2)n1 CHEMBL243088 pKi 63.1 nM
CC(C)n1cnnc1-c1cccc(N2Cc3ccccc3C2=O)n1 CHEMBL3952214 pIC50 63.1 nM
Cn1cc(-c2cncc(-c3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4C)cc3)n2)cn1 CHEMBL3596893 IC50 64.0 nM
COc1cc2c(Nc3ccc(Cl)c(Cl)c3F)ncnc2cc1OC[C@@H]1C[C@@H]2CN(C)C[C@@H]2C1 CHEMBL3544983 Kd apparent 64.0 nM
CNC(=O)c1cc2c(Oc3ccc(Nc4nn(C)cc4C(=O)NC45CC6CC(CC(C6)C4)C5)cc3F)ccnc2cc1OC CHEMBL5273620 IC50 64.3 nM
COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCCN1CCCNCC1 CHEMBL3799969 IC50 65.0 nM
COc1cc2ncnc(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)c2cc1OC CHEMBL4794496 IC50 65.3 nM
C[C@H]1Cc2c(ncnc2Oc2ccc3c(ccn3C(=O)Nc3cc(C4(C)CC4)[nH]n3)c2)CN1 CHEMBL3746776 IC50 66.0 nM
CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 CHEMBL4281823 IC50 66.0 nM
CN1CCN(Cc2ccc(NC(=O)c3cccc(/C=C/c4cnc5ccccc5c4N4CCCC4)c3)cc2C(F)(F)F)CC1 CHEMBL5182347 IC50 66.0 nM
CCN1CCN(c2cc(Nc3cc(C)n[nH]3)nc(Nc3ccc(CC(=O)Nc4ccc(C(C)C)cc4)cc3)n2)CC1 CHEMBL5078263 IC50 66.58 nM
CCn1cc(-c2ccnc3[nH]c(-c4cccc(CN(C)C)c4)cc23)c(-c2ccc(NC(=O)N(C)C)cc2)n1 CHEMBL1090479 Kd apparent 67.0 nM
Cc1nn(-c2ccnc(Nc3ccc4c(c3)c(Cl)c(C)n4C)n2)cc1CN1CC(O)C1 CHEMBL3622956 IC50 67.8 nM
CC(C)(O)Cn1nc(-c2cc(C3CC3)on2)c2c(N)ncnc21 CHEMBL3752712 IC50 68.0 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(C4=Nc5cscc5NC(=O)C4)cc3)cc2C(F)(F)F)CC1 CHEMBL4228601 IC50 71.6 nM
Cn1c(Nc2ccc(C(F)(F)F)cc2)nc2cc(Oc3ccnc(-c4ncc(C(F)(F)F)[nH]4)c3)ccc21 CHEMBL558752 Kd 72.0 nM
CC(=O)N1CCc2[nH]c(/C=C3\C(=O)Nc4ccc([N+](=O)[O-])cc43)cc2C1 CHEMBL2403378 IC50 73.0 nM
Cc1cc(Nc2cc(C)[nH]n2)nc(N2CCC3(CC2)CCN(C(C)c2ccc(-n4cc(F)cn4)nc2)C3=O)n1 CHEMBL4848545 IC50 73.87 nM
Nc1ncnc2c1c(-c1cc(C3CC3)on1)nn2Cc1ccccc1 CHEMBL3754346 IC50 74.0 nM
CC(=O)N1CCN([C@H]2C[C@@H](n3cc(-c4ccccc4O)c4c(N)ncnc43)C2)CC1 CHEMBL4864386 IC50 74.0 nM
Cc1ccc(O)cc1Nc1ccnc2cc(-c3ccccn3)ccc12 CHEMBL395358 IC50 75.0 nM
Oc1cc(Nc2ccnc3cc(-c4cccc(CNCCN5CCOCC5)c4)ccc23)c(F)cc1Cl CHEMBL237126 IC50 75.0 nM
COc1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCN(C(=O)c1cnoc1C)C3)C(=O)N2 CHEMBL2403368 IC50 75.0 nM
CC(C)(C)c1cc(NC(=O)Cc2ccc(Nc3ncnc4[nH]ccc34)cc2)no1 CHEMBL4787596 IC50 76.0 nM
COc1cc(-c2cn([C@H]3C[C@@H](N4CCN(C(C)=O)CC4)C3)c3ncnc(N)c23)ccc1Cl CHEMBL4860822 IC50 76.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1N1Cc2cnc(N)nc2N(C)C1=O CHEMBL459850 EC50 77.0 nM
COc1cc2c(Nc3c(F)ccc(O)c3C)ncnc2cc1OCC1CCN(C)CC1 CHEMBL3799843 IC50 78.0 nM
CC(C)n1nc(-c2cc(-c3cccs3)on2)c(C(N)=O)c1N CHEMBL4094670 IC50 78.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4nc(N)nc(N)c34)cc2)c1 CHEMBL1973145 pKi 79.43 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL244378 pKi 79.43 nM
CNC(=O)COc1ccc(Nc2nc(Nc3ccc(C)c(S(N)(=O)=O)c3)ncc2F)cc1 CHEMBL1978099 pKi 79.43 nM
Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O CHEMBL477772 pKi 79.43 nM
O=C(Nc1nc2c(O)cccc2s1)Nc1ccccc1-c1ccccc1 CHEMBL2002690 pKi 79.43 nM
Cc1cccc(Nc2nc(NC3CCCCC3N)cnc2C(N)=O)c1 CHEMBL1974328 pKi 79.43 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL1967531 pKi 79.43 nM
COc1ccc(-c2ccc(NC(=O)Nc3cc(F)cc(F)c3)cc2)c2c(N)noc12 CHEMBL1969190 pKi 79.43 nM
Cc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1Nc1ccc(OCC(N)=O)cc1 CHEMBL1988838 pKi 79.43 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccc(CO)cc3)cc1)cn2C1CCOC1 CHEMBL1976376 pKi 79.43 nM
CNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCNCC4)cc3)n2)s1 CHEMBL1999484 pKi 79.43 nM
Cc1ccc(O)cc1Nc1ccnc2ccc(-c3cccnc3)cc12 CHEMBL237345 IC50 80.0 nM
CCN(CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1)CCOP(=O)(O)O CHEMBL415049 Kd 80.0 nM
CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1 CHEMBL215152 Kd 80.0 nM
Cc1ccc(C)c(C#Cc2nn(C(C)C)c3ncnc(N)c23)c1 CHEMBL2058542 IC50 83.0 nM
Oc1cc(Nc2ccnc3cc(-c4cc5ccccc5o4)ccc23)ccc1Br CHEMBL237557 IC50 85.0 nM
C=CS(=O)(=O)N1CCC[C@@H]1Cn1cc(-c2ccc3c(c2)OCO3)c2c(N)ncnc21 CHEMBL4095253 IC50 89.5 nM
Cc1ccc(O)cc1Nc1ccnc2ccc(S(=O)(=O)NCC3CC3)cc12 CHEMBL395359 IC50 90.0 nM
COc1cc2c3c(-c4cccc(O)c4)c[nH]c(=O)c3n(C)c2cc1OC CHEMBL473101 IC50 90.0 nM
COc1cc2[nH]c3c(c2cc1OC)C(c1cccc(O)c1)CNC3=O CHEMBL1806510 IC50 90.0 nM
CN(C)CCNc1ccn2ncc(-c3ccc4c(c3)OCO4)c2n1 CHEMBL4536873 IC50 91.0 nM
Cc1cc(Nc2cc(-c3cnn(CCN4CCOCC4)c3)nc(Nc3ccc(CC(=O)Nc4ccccc4F)cc3)n2)[nH]n1 CHEMBL5078934 IC50 92.97 nM
Cc1cc(Nc2cc(C)[nH]n2)nc(N2CCC3(CCCN(C(C)c4ccc(-n5cc(F)cn5)nc4)C3=O)CC2)n1 CHEMBL4859271 IC50 92.99 nM
COCc1c(-c2ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)c(F)c2)c2c(N)ncnn2c1CN1CCOCC1 CHEMBL3991934 Kd apparent 93.0 nM
Cc1ccc(O)cc1Nc1ccnc2ccc(C(=O)NC(C)C)cc12 CHEMBL237346 IC50 95.0 nM
Cc1cccc(C(=O)Nc2cccc([C@H](C)Nc3cncc(Cl)n3)c2)c1 CHEMBL504075 Kd 95.0 nM
CCCCCCCn1nc(-c2cc(C3CC3)on2)c2c(N)ncnc21 CHEMBL3753242 IC50 96.0 nM
CN1CCN(Cc2ccc(NC(=O)c3cccc(/C=C/c4cnc5ccccc5c4N(C)C)c3)cc2C(F)(F)F)CC1 CHEMBL5200195 IC50 98.0 nM