CN1C(=O)[C@@H](NC(=O)c2ncc(Cc3ccccc3)o2)COc2ccccc21 CHEMBL4067372 IC50 0.05 nM
CN1C(=O)[C@@H](NC(=O)c2cc(Cc3ccccc3)on2)CSc2ccccc21 CHEMBL3785745 IC50 0.063 nM
CN1C(=O)[C@@H](NC(=O)c2nnn(Cc3ccccc3)n2)COc2ccccc21 CHEMBL4093220 IC50 0.079 nM
CN1C(=O)[C@@H](NC(=O)c2cc(Cc3ccccc3)on2)CCc2ccccc21 CHEMBL3786997 IC50 0.2 nM
Cc1ccc(-c2cn([C@H]3CC[C@@H](N)CC3)c3ncnc(N)c23)c(F)c1 CHEMBL5177284 Kd 0.28 nM
CNC(=O)c1ccc2c(c1)ncn2-c1ccc(CC(=O)OC(C)(C)C)cc1 CHEMBL4439913 IC50 0.3 nM
CC(=O)Nc1ccc2c(c1)N(C)C(=O)[C@@H](NC(=O)c1cc(Cc3ccccc3)on1)CO2 CHEMBL4068954 IC50 0.32 nM
COC(=O)Nc1ccc2c(c1)N(C)C(=O)[C@@H](NC(=O)c1cc(Cc3ccccc3)on1)CO2 CHEMBL4096224 IC50 0.32 nM
CN1C(=O)[C@@H](NC(=O)c2cc(Cc3ccccc3)[nH]n2)COc2ccccc21 CHEMBL3785482 IC50 0.4 nM
CN1C(=O)[C@@H](NC(=O)c2cn(Cc3ccccc3)cn2)COc2ccccc21 CHEMBL4069318 IC50 0.4 nM
CN1C(=O)[C@@H](NC(=O)c2cc(Cc3ccccc3)n(C)n2)COc2ccccc21 CHEMBL4060644 IC50 0.4 nM
CN1C(=O)[C@@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)COc2ccccc21 CHEMBL4071864 IC50 0.4 nM
O=C(N[C@H]1CCc2cc(F)cc(F)c2NC1=O)c1n[nH]c(Cc2ccccc2)n1 CHEMBL4452233 IC50 0.4 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Cl)C2=O)COc2ccccc21 CHEMBL4075976 pKi 0.4074 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 Ki 0.43 nM
CN1C(=O)[C@@H](NC(=O)c2cc(Cc3ccccc3)on2)COc2ccc(-c3n[nH]c(=O)o3)cc21 CHEMBL4089558 IC50 0.5 nM
CN1C(=O)[C@@H](NC(=O)c2noc(Cc3ccccc3)n2)COc2ccccc21 CHEMBL4099004 IC50 0.5 nM
CC(C)(C)C(=O)N1N=CCC1c1cccc(F)c1 CHEMBL4537171 IC50 0.5 nM
O=C(N1CC(Oc2ccccc2)C1)N1N=CC[C@H]1c1ccccc1 CHEMBL5093571 EC50 0.5 nM
CN1C(=O)[C@@H](NC(=O)c2cc(Cc3ccccc3)on2)COc2ccc(NS(C)(=O)=O)cc21 CHEMBL4081685 IC50 0.63 nM
CN1C(=O)[C@@H](NC(=O)c2ncn(Cc3ccccc3)n2)COc2ccccc21 CHEMBL4065561 IC50 0.63 nM
CN1C(=O)[C@@H](NC(=O)c2cc(Cc3ccccc3)on2)CNc2ccccc21 CHEMBL3786078 IC50 0.79 nM
CN1C(=O)[C@@H](NC(=O)c2nnc(Cc3ccccc3)o2)COc2ccccc21 CHEMBL4088857 IC50 0.79 nM
CN1C(=O)[C@@H](NC(=O)c2cc(Cc3ccccc3)on2)COc2ccccc21 CHEMBL3785703 Ki 0.8 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Cl)C2=O)COc2ccc(C#N)cc21 CHEMBL4061975 pKi 0.8511 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Cl)C2=O)COc2cc(C#N)ccc21 CHEMBL4100398 pKi 0.912 nM
CNC(=O)c1ccc2c(c1)OC[C@H](N1CCc3c(nn(Cc4ccccc4)c3Cl)C1=O)C(=O)N2C CHEMBL4069537 pKi 0.912 nM
CN1C(=O)[C@@H](NC(=O)c2cc(Cc3ccccc3)on2)COc2ccc(-c3cc[nH]n3)cc21 CHEMBL4099698 IC50 1.0 nM
CN1C(=O)[C@@H](NC(=O)c2cn(Cc3ccccc3)nn2)COc2ccccc21 CHEMBL4080978 IC50 1.0 nM
N#Cc1cc(N2CCC(C(=O)N3N=CC[C@H]3c3cc(F)cc(F)c3)CC2)ncn1 CHEMBL4514271 IC50 1.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4c(F)cccc4F)nc3C2=O)COc2ccccc21 CHEMBL4082215 pKi 1.148 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3C#N)C2=O)COc2ccccc21 CHEMBL4084681 pKi 1.148 nM
Nc1cccc(-c2cnc3[nH]cc(-c4cccc(NC(=O)Nc5cc(C(F)(F)F)ccc5F)c4)c3c2)c1 CHEMBL3109212 IC50 1.3 nM
CC(C)(C)C(=O)N1N=CCC1c1cc(F)cc(F)c1 CHEMBL4593226 IC50 1.3 nM
CC(C)S(=O)(=O)c1ccc2nccc(Nc3ccc4ncsc4c3)c2c1 CHEMBL4469781 IC50 1.3 nM
CC(C)(C)C(=O)N1N=CC[C@H]1c1ccccc1 CHEMBL4521353 IC50 1.6 nM
O=C(C1CCCCC1)N1N=CCC1c1ccccc1 CHEMBL4471642 IC50 1.6 nM
O=C(C1CCN(c2ncccn2)CC1)N1N=CC[C@H]1c1ccccc1 CHEMBL4455042 IC50 1.6 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4F)nc3C2=O)COc2ccccc21 CHEMBL4090975 pKi 1.738 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4c(F)cccc4F)nc3C2=O)COc2cc(C#N)ccc21 CHEMBL4075705 pKi 1.778 nM
CN1C(=O)[C@@H](NC(=O)c2cc(Cc3ccccc3)ccn2)COc2ccccc21 CHEMBL4071080 IC50 2.0 nM
Cc1ccc(C2CC=NN2C(=O)C(C)(C)C)cc1F CHEMBL4514028 IC50 2.0 nM
N#Cc1cnc(N2CCC(C(=O)N3N=CC[C@H]3c3cc(F)cc(F)c3)CC2)cn1 CHEMBL4450890 IC50 2.0 nM
N#Cc1nccc(N2CCC(C(=O)N3N=CC[C@H]3c3cc(F)cc(F)c3)CC2)n1 CHEMBL4541955 IC50 2.0 nM
Nc1ncnc2occ(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL247228 pKi 2.042 nM
O=C(c1ccccn1)N1CCC(C(=O)N2N=CCC2c2ccccc2)CC1 CHEMBL4575848 IC50 2.5 nM
O=C(c1cnco1)N1CCC(C(=O)N2N=CC[C@H]2c2ccccc2)CC1 CHEMBL4548784 IC50 2.5 nM
O=C(C1CCN(c2ccccn2)CC1)N1N=CC[C@H]1c1ccccc1 CHEMBL4454462 IC50 2.5 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3C(N)=O)C2=O)COc2ccccc21 CHEMBL4102622 pKi 2.512 nM
CN1C(=O)[C@@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)COc2cc(F)cc(F)c21 CHEMBL4536697 pIC50 2.512 nM
Cc1c2c(nn1Cc1ccccc1)C(=O)N([C@H]1COc3ccccc3N(C)C1=O)CC2 CHEMBL4064701 pKi 2.57 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4F)nc3C2=O)COc2cc(C#N)ccc21 CHEMBL4085728 pKi 2.951 nM
O=C(N1CC(Oc2ccccc2F)C1)N1N=CC[C@H]1c1cc(F)cc(F)c1 CHEMBL5086676 EC50 3.1 nM
CCS(=O)(=O)c1ccc(-c2cnc3[nH]cc(-c4cccc(NC(=O)Nc5cc(C(F)(F)F)ccc5F)c4)c3c2)cc1 CHEMBL3109194 IC50 3.2 nM
O=C(N[C@H]1CNc2ccccc2NC1=O)c1cc(Cc2ccccc2)on1 CHEMBL3787689 IC50 3.2 nM
CN(C)C(=O)c1ccc2c(c1)OC[C@H](N1CCc3c(nn(Cc4ccccc4)c3Cl)C1=O)C(=O)N2C CHEMBL4073321 pKi 3.467 nM
O=C(N1CC(Oc2ccccc2)C1)N1N=CC[C@H]1c1cc(F)cc(F)c1 CHEMBL5094839 EC50 3.8 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pKi 3.89 nM
O=C(Nc1cccc(-c2c[nH]c3ncc(-c4cccnc4)cc23)c1)Nc1cc(C(F)(F)F)ccc1F CHEMBL3109209 IC50 4.0 nM
Cc1ccc(C2CC=NN2C(=O)C(C)(C)C)cc1 CHEMBL4436215 IC50 4.0 nM
CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 CHEMBL4281823 Kd 4.4 nM
O=C1CCC(C(=O)Nc2nc3cc(Oc4ccc(F)c(NC(=O)Cc5cccc(OC(F)(F)F)c5)c4)c(F)cc3s2)CC1 CHEMBL5173571 Kd 4.5 nM
CC(C)(C)C(=O)N1N=CCC1c1ccccc1 CHEMBL4446915 IC50 4.8 nM
CN1C[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C(=O)N(C)c2ccccc21 CHEMBL4069959 IC50 5.0 nM
CN1C(=O)[C@@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)CCc2ccccc21 CHEMBL4554676 IC50 5.0 nM
O=C(C1CCN(c2ccncn2)CC1)N1N=CC[C@H]1c1ccccc1 CHEMBL4443534 IC50 5.0 nM
CN1C(=O)[C@@H](NC(=O)c2n[nH]c3ccc(C(F)(F)F)cc23)COc2ccccc21 CHEMBL4761749 Ki(app) 5.0 nM
CN1C(=O)[C@@H](NC(=O)c2ncn3ccc(C(F)(F)F)cc23)COc2ccccc21 CHEMBL4795841 Ki(app) 5.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4cccc(F)c4)nc3C2=O)COc2ccccc21 CHEMBL4071690 pKi 5.129 nM
O=C(c1ccccc1)C1CN(C(=O)N2N=CC[C@H]2c2cc(F)cc(F)c2)C1 CHEMBL5093043 EC50 5.6 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3cccc4ncccc34)c(F)c2)ccn1 CHEMBL5171111 IC50 5.7 nM
CN1C(=O)[C@@H](NC(=O)c2nc(Cc3ccccc3)n[nH]2)COc2ccc(C#CC3CC3)cc21 CHEMBL5173634 IC50 5.7 nM
O=C(N1CC(Sc2ccc(Br)cc2)C1)N1N=CC[C@H]1c1cc(F)cc(F)c1 CHEMBL5089545 EC50 5.9 nM
O=C(Nc1cccc(-c2c[nH]c3ncc(-c4cn[nH]c4)cc23)c1)Nc1cc(C(F)(F)F)ccc1F CHEMBL3109214 IC50 6.0 nM
CN1C(=O)[C@@H](NC(=O)c2n[nH]c3ncc(C(F)(F)C(F)(F)F)cc23)COc2ccccc21 CHEMBL4785812 Ki(app) 6.0 nM
COc1cccc(NC(=O)Nc2cccc(-c3c[nH]c4ncc(-c5ccccc5)cc34)c2)c1 CHEMBL3109205 IC50 6.3 nM
CN1C(=O)[C@@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)CCc2cc(F)cc(F)c21 CHEMBL4453758 IC50 6.3 nM
CC(C)(C)C(=O)N1N=CCC1c1ccc(Cl)cc1 CHEMBL4576386 IC50 6.3 nM
O=C(c1cocn1)N1CCC(C(=O)N2N=CCC2c2ccccc2)CC1 CHEMBL4584779 IC50 6.3 nM
Cc1cc(-c2cnc(N)c3c(-c4ccc5scnc5c4)csc23)n(C)n1 CHEMBL4441118 IC50 6.5 nM
CN1C(=O)[C@@H](NC(=O)c2n[nH]c3c2C[C@H](C(F)(F)F)CC3)COc2ccccc21 CHEMBL4790507 Ki(app) 7.0 nM
O=C(N[C@H]1COc2ccccc2NC1=O)c1cccc(Oc2ccccc2)c1 CHEMBL3786162 IC50 7.9 nM
N#Cc1ccc(N2CCC(C(=O)N3N=CC[C@H]3c3cc(F)cc(F)c3)CC2)nn1 CHEMBL4561445 IC50 7.9 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccc(F)cc4)nc3C2=O)COc2ccccc21 CHEMBL4098708 pKi 7.943 nM
Cc1nnc(N2CCC(C(=O)N3N=CC[C@H]3c3cc(F)cc(F)c3)CC2)o1 CHEMBL4545939 IC50 8.5 nM
O=C1CC(C(=O)Nc2nc3cc(Oc4ccc(F)c(NC(=O)Cc5cccc(OC(F)(F)F)c5)c4)c(F)cc3s2)C1 CHEMBL5172295 Kd 8.6 nM
CC(C)(C)C(=O)N1N=CCC1c1cccc(Cl)c1 CHEMBL4556131 IC50 9.0 nM
Cc1ncc(-c2ccc3nc(NC(=O)C4CC4)sc3c2)cc1NC(=O)OC1CCOCC1 CHEMBL5083542 Kd 9.2 nM
O=C1CCC(C(=O)Nc2nc3cc(Oc4ccc(F)c(NC(=O)Cc5cccc(OC(F)(F)F)c5)c4)c(F)cc3s2)C1 CHEMBL5185667 Kd 9.6 nM
C#Cc1ccc2c(c1)N(C)C(=S)[C@@H](NC(=O)c1n[nH]c(Cc3ccccc3)n1)CO2 CHEMBL5440251 Kd 9.7 nM
CCc1cccc(NC(=O)Nc2ccc(-c3coc4ncnc(N)c34)cc2)c1 CHEMBL3109219 IC50 10.0 nM
Nc1ncnc2occ(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)c12 CHEMBL273564 IC50 10.0 nM
CS(=O)(=O)c1cccc(-c2cnc3[nH]cc(-c4cccc(NC(=O)Nc5cc(C(F)(F)F)ccc5F)c4)c3c2)c1 CHEMBL3109211 IC50 10.0 nM
NC(=O)c1cccc(-c2cnc3[nH]cc(-c4cccc(NC(=O)Nc5cc(C(F)(F)F)ccc5F)c4)c3c2)c1 CHEMBL3109210 IC50 10.0 nM
CC(=O)c1cccc(NC(=O)Nc2cccc(-c3c[nH]c4ncc(-c5ccccc5)cc34)c2)c1 CHEMBL3109206 IC50 10.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cccc4c(N)nccc34)cc2)no1 CHEMBL3109202 IC50 10.0 nM
Nc1nccc2c(-c3ccc(NC(=O)Nc4ccc(F)c(C(F)(F)F)c4)cc3)cccc12 CHEMBL3109198 IC50 10.0 nM
CCCCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 CHEMBL4290735 IC50 10.0 nM
CC(C)n1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 CHEMBL4292454 IC50 10.0 nM
Cn1nc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 CHEMBL4279118 IC50 10.0 nM
O=C(N[C@H]1CNc2cccc(F)c2NC1=O)c1nnc(Cc2ccccc2F)[nH]1 CHEMBL4522283 pIC50 10.0 nM
CC(C)(C)C(=O)N1N=CCC1c1ccc(C(C)(C)C)cc1 CHEMBL4533161 IC50 10.0 nM
CC(C)(C)C(=O)N1N=CCC1c1ccc(S(C)(=O)=O)cc1 CHEMBL4436896 IC50 10.0 nM
CC(C)(C)C(=O)N1N=CCC1c1ccccn1 CHEMBL4544356 IC50 10.0 nM
CC(C)(C)C(=O)N1N=CCC1c1cccnc1 CHEMBL4446523 IC50 10.0 nM
CC(C)(C)C(=O)N1N=CCC1c1ccncc1 CHEMBL4448908 IC50 10.0 nM
CC(C)(C)C(=O)N1N=CCC1c1cc[nH]n1 CHEMBL4446758 IC50 10.0 nM
CC(C)(C)C(=O)N1N=CCC1c1c[nH]cn1 CHEMBL4446928 IC50 10.0 nM
CC(C)(C)C(=O)N1N=CCC1c1cocn1 CHEMBL4440532 IC50 10.0 nM
CC(C)(C)C(=O)N1N=CCC1C1CCCCC1 CHEMBL4590117 IC50 10.0 nM
CC(C)(C)C(=O)N1N=CCC1C1CCCC1 CHEMBL4467752 IC50 10.0 nM
CC(C)(C)C(=O)N1N=CCC1C1CCOCC1 CHEMBL4472572 IC50 10.0 nM
CN1CCC(C2CC=NN2C(=O)C(C)(C)C)CC1 CHEMBL4452768 IC50 10.0 nM
CC(C)C(=O)N1N=CCC1c1ccccc1 CHEMBL4519627 IC50 10.0 nM
CC(C)(CO)C(=O)N1N=CCC1c1ccccc1 CHEMBL4451628 IC50 10.0 nM
CC(C)(CN)C(=O)N1N=CCC1c1ccccc1 CHEMBL4437098 IC50 10.0 nM
O=C(C1CCCC1)N1N=CCC1c1ccccc1 CHEMBL4457026 IC50 10.0 nM
O=C(C1CCC1)N1N=CCC1c1ccccc1 CHEMBL4436131 IC50 10.0 nM
O=C(C1CCOCC1)N1N=CCC1c1ccccc1 CHEMBL4474301 IC50 10.0 nM
O=C(C1CCOC1)N1N=CCC1c1ccccc1 CHEMBL4474937 IC50 10.0 nM
O=C(c1ccccc1)N1N=CCC1c1ccccc1 CHEMBL4564157 IC50 10.0 nM
O=C(c1ccncc1)N1N=CCC1c1ccccc1 CHEMBL4452678 IC50 10.0 nM
O=C(c1cccnc1)N1N=CCC1c1ccccc1 CHEMBL4554458 IC50 10.0 nM
O=C(c1ccccn1)N1N=CCC1c1ccccc1 CHEMBL4519892 IC50 10.0 nM
CN1CCC(C(=O)N2N=CCC2c2ccccc2)CC1 CHEMBL4527680 IC50 10.0 nM
O=C(C1CCN(c2ccccc2)CC1)N1N=CCC1c1ccccc1 CHEMBL4565985 IC50 10.0 nM
CC(=O)N1CCC(C(=O)N2N=CCC2c2ccccc2)CC1 CHEMBL4553214 IC50 10.0 nM
CC(=O)N1CCC(C(=O)N2N=CC[C@H]2c2ccccc2)CC1 CHEMBL4474320 IC50 10.0 nM
O=C(C1CCN(C(=O)C(F)(F)F)CC1)N1N=CCC1c1ccccc1 CHEMBL4463322 IC50 10.0 nM
CCC(=O)N1CCC(C(=O)N2N=CCC2c2ccccc2)CC1 CHEMBL4526661 IC50 10.0 nM
O=C(C1CCCCC1)N1CCC(C(=O)N2N=CCC2c2ccccc2)CC1 CHEMBL4448942 IC50 10.0 nM
O=C(c1ccccc1)N1CCC(C(=O)N2N=CCC2c2ccccc2)CC1 CHEMBL4588685 IC50 10.0 nM
O=C(c1cccnc1)N1CCC(C(=O)N2N=CCC2c2ccccc2)CC1 CHEMBL4548719 IC50 10.0 nM
O=C(c1cc[nH]n1)N1CCC(C(=O)N2N=CCC2c2ccccc2)CC1 CHEMBL4583157 IC50 10.0 nM
O=C(c1cn[nH]c1)N1CCC(C(=O)N2N=CCC2c2ccccc2)CC1 CHEMBL4524420 IC50 10.0 nM
O=C(c1c[nH]nn1)N1CCC(C(=O)N2N=CCC2c2ccccc2)CC1 CHEMBL4465743 IC50 10.0 nM
O=C(c1cscn1)N1CCC(C(=O)N2N=CC[C@H]2c2ccccc2)CC1 CHEMBL4552893 IC50 10.0 nM
O=C(C1CCN(c2ccccc2)CC1)N1N=CC[C@H]1c1ccccc1 CHEMBL4594130 IC50 10.0 nM
O=C(C1CCN(c2cccnn2)CC1)N1N=CC[C@H]1c1ccccc1 CHEMBL4556751 IC50 10.0 nM
Cc1nnc(N2CCC(C(=O)N3N=CC[C@H]3c3ccccc3)CC2)o1 CHEMBL4454881 IC50 10.0 nM
CCC(C)(C)C(=O)N(C)Cc1cc(F)cc(F)c1F CHEMBL4085167 EC50 12.0 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1171837 IC50 12.0 nM
O=C(Cc1cccc(OC(F)(F)F)c1)Nc1cc(Oc2cc3nc(NC(=O)C4CCOC4)sc3cc2F)ccc1F CHEMBL5171828 Kd 12.0 nM
Cc1cccc(NC(=O)Nc2cccc(-c3c[nH]c4ncc(-c5ccccc5)cc34)c2)c1 CHEMBL3108785 IC50 13.0 nM
Nc1nccc2c(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)cccc12 CHEMBL3109196 IC50 13.0 nM
CCC(C)(C)C(=O)N(O)Cc1ccccc1 CHEMBL4092421 IC50 13.0 nM
Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 CHEMBL4290948 IC50 13.0 nM
Nc1cc(N2CCC(C(=O)N3OCC[C@H]3c3cc(F)cc(F)c3)CC2)ncn1 CHEMBL5415623 IC50 13.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCC4)nc3C2=O)COc2ccccc21 CHEMBL4060308 pKi 13.8 nM
Cn1nc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(C(F)(F)F)c2)c2c(N)ncnc21 CHEMBL4289355 IC50 14.0 nM
N#CC12CC(n3nc4n(c3=O)[C@H](c3cc(F)cc(F)c3)CC4)(C1)C2 CHEMBL5428344 EC50 14.8 nM
O=C(Cc1cccc(C(F)(F)F)c1)Nc1cc(Oc2cc3sc(NC(=O)C4CC4)nc3cc2F)ccc1F CHEMBL5209456 Kd 15.0 nM
CC(C)C(=O)NC1CCC(C(=O)Nc2nc3cc(F)c(Oc4ccc(F)c(NC(=O)Cc5cccc(C(F)(F)F)c5)c4)cc3s2)CC1 CHEMBL5419480 Kd 15.0 nM
COCC(=O)NC1CCC(C(=O)Nc2nc3cc(F)c(Oc4ccc(F)c(NC(=O)Cc5cccc(C(F)(F)F)c5)c4)cc3s2)CC1 CHEMBL5432050 Kd 15.0 nM
CCOCC(=O)NC1CCC(C(=O)Nc2nc3cc(F)c(Oc4ccc(F)c(NC(=O)Cc5cccc(C(F)(F)F)c5)c4)cc3s2)CC1 CHEMBL5404951 Kd 15.0 nM
Cc1c(F)cc([C@@H]2CCc3nn(C45CC(F)(C4)C5)c(=O)n32)cc1F CHEMBL5428474 EC50 15.75 nM
Nc1ccc(-c2cnc3[nH]cc(-c4cccc(NC(=O)Nc5cc(C(F)(F)F)ccc5F)c4)c3c2)cc1 CHEMBL3109213 IC50 16.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3coc4ncnc(N)c34)cc2)no1 CHEMBL3109221 IC50 16.0 nM
O=C(Nc1cccc(-c2c[nH]c3ncc(-c4ccccc4)cc23)c1)Nc1cccc([N+](=O)[O-])c1 CHEMBL3109203 IC50 16.0 nM
O=C(N[C@H]1COc2ccccc2NC1=O)c1cc(Cc2ccccc2)on1 CHEMBL3786293 IC50 16.0 nM
C[C@@H]1CCc2[nH]nc(C(=O)N[C@H]3COc4ccccc4N(C)C3=O)c2C1 CHEMBL4788837 Ki(app) 16.0 nM
Cc1c(F)cc([C@@H]2CCc3nn(C45CC(C#N)(C4)C5)c(=O)n32)cc1F CHEMBL5413896 EC50 16.1 nM
O=c1n(C23CC(F)(C2)C3)nc2n1[C@H](c1cc(F)c(Cl)c(F)c1)CC2 CHEMBL5411784 EC50 16.7 nM
Cn1nc(-c2ccc3c(c2)CCN3C(=O)CCc2cccc(C(F)(F)F)c2)c2c(N)ncnc21 CHEMBL4285969 IC50 17.0 nM
N#Cc1cc(F)cc([C@@H]2CCON2C(=O)C2CCN(c3cc(N)ncn3)CC2)c1 CHEMBL5431192 IC50 17.0 nM
COc1cc(N2CCC(C(=O)N3OCC[C@H]3c3cc(F)cc(Cl)c3)CC2)ncn1 CHEMBL5405225 IC50 17.0 nM
Cc1cc(F)cc([C@@H]2CCc3nn(C45CC(F)(C4)C5)c(=O)n32)c1 CHEMBL5420508 EC50 17.0 nM
O=C(Cc1cccc(OC(F)(F)F)c1)Nc1cc(-c2ccc3nc(NC(=O)C4CC4)sc3c2)ccc1F CHEMBL5402170 Kd 17.0 nM
O=c1n(C23CC(F)(C2)C3)nc2n1[C@H](c1ccc(Cl)c(F)c1)CC2 CHEMBL5418714 EC50 17.1 nM
CN1C(=O)N[C@H](Cc2c[nH]c3c(Cl)cccc23)C1=O CHEMBL370438 EC50 18.0 nM
Cn1nc(-c2ccc3c(c2)CCN3C(=O)Cc2cc(F)cc(C(F)(F)F)c2)c2c(N)ncnc21 CHEMBL4292027 IC50 18.0 nM
Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(C(F)(F)F)c2)c2c(N)ncnc21 CHEMBL2171124 IC50 18.0 nM
O=C(Cc1cccc(OC(F)(F)F)c1)Nc1cc(Oc2cc3nc(NC(=O)C4CC4F)sc3cc2F)ccc1F CHEMBL5189581 Kd 18.0 nM
COc1ncnc(N2CCC(C(=O)N3OCC[C@H]3c3cc(F)cc(C#N)c3)CC2)c1F CHEMBL5422508 IC50 18.0 nM
Cc1ccc(Nc2ncc3c(n2)N(C)C(=O)N(c2cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc2C)C3)cn1 CHEMBL1214141 IC50 18.9 nM
CN(c1ccc(NC(=O)Nc2cc(C(F)(F)F)ccc2F)cc1)c1ccnc(Nc2cccc(S(N)(=O)=O)c2)n1 CHEMBL189354 Kd 19.0 nM
O=C(N[C@H]1CNc2cc(Cl)ccc2NC1=O)c1nnc(Cc2ccccc2)[nH]1 CHEMBL4438217 pIC50 19.95 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL572878 Kd 20.0 nM
Nc1nccc2c(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)cccc12 CHEMBL3109195 IC50 20.0 nM
Cc1ccc(Oc2ccnc3cc(-c4cnn(C5CCCCC5)c4)ccc23)cc1 CHEMBL4474235 IC50 20.8 nM
COc1ccc2c(c1)CC[C@H](NC(=O)c1nc3n(n1)[C@H](c1ccccc1)CC3)C(=O)N2C CHEMBL4455611 Ki(app) 21.0 nM
COc1cc2c(cn1)N(C)C(=O)[C@@H](NC(=O)c1nc3n(n1)[C@H](c1ccccc1)CC3)CC2 CHEMBL5208359 IC50 21.0 nM
COc1cc(N2CCC(C(=O)N3OCC[C@H]3c3cc(F)c(C)c(C#N)c3)CC2)ncn1 CHEMBL5394372 IC50 22.0 nM
Cc1c(F)cc([C@@H]2CCON2C(=O)C2CCN(c3cc(N)ncn3)CC2)cc1C#N CHEMBL5418785 IC50 23.0 nM
CN1C(=O)[C@@H](NC(=O)c2nnn3c2CC(C(F)(F)C(F)(F)F)CC3)COc2ccccc21 CHEMBL4756878 Ki(app) 24.0 nM
Nc1nccc2c(-c3ccc(NC(=O)Nc4cc(F)cc(C(F)(F)F)c4)cc3)cccc12 CHEMBL3109197 IC50 25.0 nM
CC1(C)CC1C(=O)Nc1nc2cc(Oc3ccc(F)c(NC(=O)Cc4cccc(OC(F)(F)F)c4)c3)c(F)cc2s1 CHEMBL5179151 Kd 25.0 nM
Cn1nc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(Br)c2)c2c(N)ncnc21 CHEMBL4289802 IC50 26.0 nM
Cn1nc(-c2ccc3c(c2)CCN3C(=O)Cc2ccc(Cl)c(C(F)(F)F)c2)c2c(N)ncnc21 CHEMBL4283766 IC50 28.0 nM
CN1C(=O)[C@@H](NC(=O)c2n[nH]c3c2CC(c2ccccc2)CC3)COc2ccccc21 CHEMBL4792456 Ki(app) 28.0 nM
CCCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 CHEMBL4292726 IC50 31.0 nM
CN1C(=S)[C@@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)COc2ccccc21 CHEMBL4871408 Kd 31.0 nM
CN1C(=S)[C@@H](NC(=O)c2nc(Cc3ccccc3)n(C)n2)COc2ccccc21 CHEMBL5188220 Kd 31.0 nM
Nc1ncnc2occ(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)cc(C(F)(F)F)c4)cc3)c12 CHEMBL396107 IC50 32.0 nM
Nc1ncnc2occ(-c3ccc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)cc3)c12 CHEMBL3109218 IC50 32.0 nM
O=C(Nc1cccc(-c2c[nH]c3ncc(-c4ccccc4)cc23)c1)Nc1cccc(C(F)(F)F)c1 CHEMBL3109204 IC50 32.0 nM
O=C(N[C@H]1COc2ccccc2NC1=O)c1n[nH]c(Cc2ccccc2)n1 CHEMBL4068352 IC50 32.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4cccnc4)nc3C2=O)COc2ccccc21 CHEMBL4090065 pKi 33.88 nM
CN1C(=O)[C@@H](NC(=O)c2cc(Cc3cccc(C4(C(F)(F)F)N=N4)c3)[nH]n2)COc2ccccc21 CHEMBL3786660 IC50 35.0 nM
CC(C)C(=O)Nc1nc2cc(-c3ccc4c(c3)c(C(=O)NC(C)c3ccccc3)cn4C)ccn2n1 CHEMBL5403081 IC50 35.0 nM
CCC(C)(C)C(=O)N(C)Cc1cc(F)ccc1F CHEMBL4076443 EC50 36.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccn4)nc3C2=O)COc2ccccc21 CHEMBL4076592 pKi 38.02 nM
CN1C(=O)[C@@H](NC(=O)c2n[nH]c(Cc3ccccc3F)n2)CNc2ccccc21 CHEMBL4461132 pIC50 39.81 nM
Nc1nccc2c(-c3ccc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)cc3)cccc12 CHEMBL3109200 IC50 40.0 nM
CN1C(=S)[C@@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)COc2ccc(C#CC3CC3)cc21 CHEMBL5423528 Kd 40.0 nM
CN1C(=O)[C@@H](NC(=O)c2n[nH]c3c2CC(C)(C)CC3)COc2ccccc21 CHEMBL4783819 Ki(app) 42.0 nM
O=C(Cc1cccc(C(F)(F)F)c1)Nc1cc(Oc2cc3sc(NC(=O)C4CCC(NC(=O)CCCl)CC4)nc3cc2F)ccc1F CHEMBL5418766 Kd 43.0 nM
CCCCC(=O)NC1CCC(C(=O)Nc2nc3cc(F)c(Oc4ccc(F)c(NC(=O)Cc5cccc(C(F)(F)F)c5)c4)cc3s2)CC1 CHEMBL5399892 Kd 45.0 nM
CN1C(=O)[C@@H](NC(=O)c2n[nH]c3c2C[C@H](C(C)(C)C)CC3)COc2ccccc21 CHEMBL4779136 Ki(app) 48.0 nM
CCC(C)(C)C(=O)N(O)Cc1cc(F)c(F)c(F)c1 CHEMBL4083065 EC50 49.0 nM
Cn1nc(-c2ccc3c(c2)CCN3C(=O)Nc2cccc(C(F)(F)F)c2)c2c(N)ncnc21 CHEMBL4278044 IC50 49.0 nM
Cn1nc(-c2ccc(NC(=O)Cc3cccc(C(F)(F)F)c3)cc2F)c2c(N)ncnc21 CHEMBL4290430 IC50 49.0 nM
O=C(Cc1cccc(OC(F)(F)F)c1)Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)sc3c2)ccc1F CHEMBL4439346 Kd 49.0 nM
O=C(Cc1cccc(OC(F)(F)F)c1)Nc1cc(Oc2cc3nc(NC(=O)C4CC4)sc3cc2F)ccc1F CHEMBL5189681 Kd 49.0 nM
CC(NC(=O)c1cn(C)c2ccc(-c3ccn4nc(NC(=O)C5CC5)cc4n3)cc12)c1ccc(F)cc1 CHEMBL5430224 IC50 49.0 nM
O=C(N[C@H]1CCc2ccccc2NC1=O)c1n[nH]c(Cc2ccccc2)n1 CHEMBL4470945 IC50 50.0 nM
CN1C(=O)[C@@H](N2CCn3nc(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4100309 pKi 54.95 nM
CC(C)c1cnc2[nH]nc(C(=O)N[C@H]3COc4ccccc4N(C)C3=O)c2c1 CHEMBL4746817 Ki(app) 55.0 nM
CCC(C)(C)C(=O)N(O)Cc1ccc(F)c(F)c1 CHEMBL4072591 EC50 56.0 nM
Cc1cccc(CC(=O)N2CCc3cc(-c4nn(C)c5ncnc(N)c45)ccc32)c1 CHEMBL4283246 IC50 56.0 nM
CCC(C)(C)C(=O)N(C)Cc1cccc(F)c1F CHEMBL4101314 EC50 58.0 nM
Cn1nc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(Cl)c2)c2c(N)ncnc21 CHEMBL4289381 IC50 58.0 nM
CN1C(=S)[C@@H](NC(=O)c2nc(Cc3ccccc3)n(CCF)n2)COc2ccccc21 CHEMBL5180233 Kd 60.0 nM
Cn1nc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(F)c2)c2c(N)ncnc21 CHEMBL4281501 IC50 61.0 nM
Nc1ncnc2occ(-c3ccc(NC(=O)Nc4cc(F)cc(C(F)(F)F)c4)cc3)c12 CHEMBL3109216 IC50 63.0 nM
CN1C(=O)[C@@H](NC(=O)c2cnn(Cc3ccccc3)c2)COc2ccccc21 CHEMBL4096551 IC50 63.0 nM
CN1C(=O)[C@@H](NC(=O)c2nn(C)c3c2C[C@H](C(F)(F)F)CC3)COc2ccccc21 CHEMBL4793776 Ki(app) 63.0 nM
O=[N+]([O-])c1ccc2[nH]c(Cc3ccccc3)nc2c1 CHEMBL4077039 pKi 63.1 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 64.0 nM
CCC(C)(C)C(=O)N(O)Cc1ccc(F)cc1 CHEMBL4063996 EC50 64.0 nM
CN1C(=O)[C@@H](NC(=O)c2nnn3c2C[C@H](C(F)(F)F)CC3)COc2ccccc21 CHEMBL4764530 Ki(app) 64.0 nM
CN(c1ccc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1)c1ccnc(Nc2cccc(S(N)(=O)=O)c2)n1 CHEMBL188381 Kd 64.0 nM
CC(NC(=O)c1cn(C)c2ccc(-c3ccn4nc(NC(=O)C5CC5)cc4n3)cc12)c1ccccc1 CHEMBL5427031 IC50 65.0 nM
CN1C(=O)[C@@H](NC(=O)c2nnc3ccc(C(F)(F)C(F)(F)F)nn23)COc2ccccc21 CHEMBL4783919 Ki(app) 68.0 nM
Cn1cc(-c2ccc3c(c2F)CCN3C(=O)Cc2cccc(C(F)(F)F)n2)c2c(N)ncnc21 CHEMBL2441342 IC50 69.0 nM
O=C(Cc1cccc(C(F)(F)F)c1)Nc1cc(Oc2cc3sc(NC(=O)C4CCC(NC(=O)c5cccs5)CC4)nc3cc2F)ccc1F CHEMBL5414389 Kd 69.0 nM
Cc1cccc(CC(=O)N2CCc3c2ccc(-c2cn(C)c4ncnc(N)c24)c3F)n1 CHEMBL2441340 IC50 69.1 nM
CN1C(=S)[C@@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)COc2ccc(C#Cc3cccc(C#N)c3)cc21 CHEMBL5432442 Kd 70.0 nM
CCC(C)(C)C(=O)N(C)Cc1cccc(F)c1 CHEMBL4096278 EC50 72.0 nM
Cc1ccc(O)cc1Nc1ccnc2cc(-c3ccccn3)ccc12 CHEMBL395358 IC50 73.6 nM
CCC(C)(C)C(=O)N(O)Cc1cc(F)cc(F)c1F CHEMBL4061192 EC50 74.0 nM
Cn1nc(-c2ccc(NC(=O)Cc3cccc(C(F)(F)F)c3)cc2)c2c(N)ncnc21 CHEMBL4291229 IC50 77.0 nM
O=[N+]([O-])c1nn(Cc2cc(F)ccc2F)cc1Br CHEMBL5182551 Kd 78.0 nM
CN1C(=S)[C@@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)COc2ccc(C#Cc3ccccc3C#N)cc21 CHEMBL5403662 Kd 78.0 nM
O=C(N[C@H]1CS(=O)(=O)c2ccccc2NC1=O)c1cc(Cc2ccccc2)on1 CHEMBL3785838 IC50 79.0 nM
Cn1nc(-c2ccc(NC(=O)Cc3cccc(C(F)(F)F)c3)c(F)c2)c2c(N)ncnc21 CHEMBL4287016 IC50 79.0 nM
CC(C)(C)C(=O)N1CCC1c1ccccc1 CHEMBL4540090 IC50 79.0 nM
CC(C)(C)C(=O)N1CCCC1c1cccc(F)c1 CHEMBL4438495 IC50 79.0 nM
CCn1nc(C(=O)N[C@H]2COc3ccccc3N(C)C2=S)nc1Cc1ccccc1 CHEMBL5177347 Kd 79.0 nM
O=C(Nc1cccc(-c2c[nH]c3ncc(-c4ccccc4)cc23)c1)Nc1cc(C(F)(F)F)ccc1F CHEMBL3109207 IC50 80.0 nM
COC(=O)c1ccc(C#Cc2ccc3c(c2)N(C)C(=S)[C@@H](NC(=O)c2n[nH]c(Cc4ccccc4)n2)CO3)cc1 CHEMBL5419190 Kd 83.0 nM
CCS(=O)(=O)NC1CCC(C(=O)Nc2nc3cc(F)c(Oc4ccc(F)c(NC(=O)Cc5cccc(C(F)(F)F)c5)c4)cc3s2)CC1 CHEMBL5431590 Kd 85.0 nM
O=C(c1ccc(-c2cc3cccnc3[nH]2)cc1)N1CCOCC1 CHEMBL5427291 IC50 88.0 nM
CC(=O)Nc1nc2ccc(-c3cnc(C)c(CC(=O)OC4CCCCC4)c3)cc2s1 CHEMBL4464023 IC50 90.0 nM
Cc1ccc(CCCCN2C(=O)N[C@H](Cc3c[nH]c4c(Cl)cccc34)C2=O)cc1C#Cc1cnc2cccnn12 CHEMBL4464634 IC50 90.0 nM
COc1ccc(-c2cc3ccc[nH]c-3n2)cc1 CHEMBL79711 IC50 90.0 nM
CC(C)(C)NC(=O)c1ccc(-c2cc3cccnc3[nH]2)cc1 CHEMBL5432235 IC50 90.0 nM
Cn1ccc2ccc(C(=O)N3CCC4(CC3)CCN(Cc3cc(F)ccc3F)C4=O)cc21 CHEMBL5179059 IC50 92.0 nM
CN1C(=S)[C@@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)COc2ccc(C#Cc3ccc(C#N)cc3)cc21 CHEMBL5398941 Kd 92.0 nM
CNC(=O)c1ccc(-c2cc3cccnc3[nH]2)cc1 CHEMBL5396051 IC50 93.0 nM
Cn1nc(-c2ccc(NC(=O)Cc3cccc(C(F)(F)F)c3)c(Cl)c2)c2c(N)ncnc21 CHEMBL4279092 IC50 94.0 nM
O=C(Cc1cccc(C(F)(F)F)c1)Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)sc3c2)ccc1F CHEMBL4540715 Kd 97.0 nM
O=C(Cc1cccc(C(F)(F)F)c1)Nc1cc(Oc2cc3nc(NC(=O)C4CC4)sc3cc2F)ccc1F CHEMBL5205822 Kd 97.0 nM
CN(Cc1cc(F)cc(F)c1F)C(=O)C(C)(C)C CHEMBL4083937 EC50 98.0 nM
CN1C(=O)[C@@H](NC(=O)c2n[nH]c3ncc(C(F)(F)F)cc23)COc2ccccc21 CHEMBL4740099 Ki(app) 98.0 nM
Nc1ncnc2occ(-c3ccc(NC(=O)Nc4ccc5ccccc5c4)cc3)c12 CHEMBL436806 IC50 100.0 nM
CCCCCc1cc(C(=O)N[C@H]2COc3ccccc3N(C)C2=O)no1 CHEMBL4062496 IC50 100.0 nM
C[C@H]1CCc2[nH]nc(C(=O)N[C@H]3COc4ccccc4N(C)C3=O)c2C1 CHEMBL4761296 Ki(app) 100.0 nM
O=C(c1ccc(-c2cc3cccnc3[nH]2)cc1)N1CCNCC1 CHEMBL5404074 IC50 100.0 nM
CN1CCN(C(=O)c2ccc(-c3cc4cccnc4[nH]3)cc2)CC1 CHEMBL5434132 IC50 100.0 nM
COCCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 CHEMBL4289311 IC50 105.0 nM
N#Cc1c(Oc2ccc(F)c(NC(=O)Cc3cccc(C(F)(F)F)c3)c2)ccc2nc(NC(=O)C3CC3)sc12 CHEMBL3125890 Kd 105.0 nM
CCc1cc(-c2nn(C)c3ncnc(N)c23)ccc1NC(=O)Cc1cccc(C(F)(F)F)c1 CHEMBL4285949 IC50 107.0 nM
CN1C(=O)[C@@H](N2CCn3cc(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4066941 pKi 107.15 nM
NC(=O)c1ccc(-c2cc3cccnc3[nH]2)cc1 CHEMBL5416808 IC50 110.0 nM
COc1cccc(CC(=O)N2CCc3cc(-c4nn(C)c5ncnc(N)c45)ccc32)c1 CHEMBL4282588 IC50 116.0 nM
CN1C(=O)[C@@H](N2CCc3[nH]c(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4082291 pKi 117.49 nM
COc1cc(-c2cc3cccnc3[nH]2)ccc1O CHEMBL5432711 IC50 120.0 nM
O=C(c1ccc(-c2cc3cccnc3[nH]2)cc1)N1CCCCC1 CHEMBL5434486 IC50 120.0 nM
CCC(C)(C)C(=O)N(C)Cc1ccccc1F CHEMBL4059584 EC50 125.0 nM
O=C(Nc1cccc(Cl)c1)N1N=CCC1c1ccccc1 CHEMBL1580000 IC50 126.0 nM
CC1=NN(C(=O)C(C)(C)C)[C@H](c2ccccc2)C1 CHEMBL4545356 IC50 126.0 nM
Cn1nc(-c2ccc3c(c2)CCN3C(=O)Cc2ccc(C(F)(F)F)cc2)c2c(N)ncnc21 CHEMBL4290879 IC50 128.0 nM
COc1cc(O)c2c(c1)OC(O)(c1ccc(OCc3ccccc3)cc1)CC2=O CHEMBL4534082 Kd 130.0 nM
CC(C)N(C(=O)c1ccc(-c2cc3cccnc3[nH]2)cc1)C(C)C CHEMBL5404174 IC50 130.0 nM
Cc1cc(-c2nn(C)c3ncnc(N)c23)ccc1NC(=O)Cc1cccc(C(F)(F)F)c1 CHEMBL4282562 IC50 134.0 nM
O=C(Cc1cccc(OC(F)(F)F)c1)Nc1cccc(-c2ccc3nc(NC(=O)C4CC4)sc3c2)c1F CHEMBL5429816 Kd 140.0 nM
O=C(c1ccc(-c2cc3cccnc3[nH]2)cc1)N1CCCC1 CHEMBL5409414 IC50 140.0 nM
CN1C(=S)[C@@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)COc2ccc(C#Cc3ccc([N+](=O)[O-])cc3)cc21 CHEMBL5433218 Kd 150.0 nM
Nc1ncnc2occ(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12 CHEMBL3109220 IC50 160.0 nM
Nc1ncnc2occ(-c3ccc(NC(=O)Nc4ccc(F)c(C(F)(F)F)c4)cc3)c12 CHEMBL3109215 IC50 160.0 nM
COC(=O)c1cccc(C#Cc2ccc3c(c2)N(C)C(=S)[C@@H](NC(=O)c2n[nH]c(Cc4ccccc4)n2)CO3)c1 CHEMBL5419556 Kd 160.0 nM
Cc1cc(Nc2cc(N3CCOCC3)nc(Nc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL4090723 IC50 167.0 nM
NC(=O)c1ccc(-c2cnc3[nH]ccc3c2)cc1 CHEMBL5401530 IC50 170.0 nM
OCc1ccc(-c2cc3cccnc3[nH]2)cc1 CHEMBL5413548 IC50 170.0 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Nc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL4105556 IC50 178.0 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1)c1cccn(-c2ccc(F)cc2)c1=O CHEMBL4455682 IC50 180.0 nM
CCNC(=O)c1ccc(-c2cc3cccnc3[nH]2)cc1 CHEMBL5412064 IC50 180.0 nM
CN1C(=O)C(Cc2c[nH]c3ccccc23)NC1=S CHEMBL195008 EC50 182.0 nM
O=C(c1ccccc1)N1CCC2(CC1)CCN(Cc1ccccc1F)C2=O CHEMBL5198841 IC50 186.0 nM
Cn1nc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(C#N)c2)c2c(N)ncnc21 CHEMBL4283005 IC50 190.0 nM
CN1C(=O)[C@@H](NC(=O)c2cc3cccc(-c4ccccc4)c3[nH]2)COc2ccccc21 CHEMBL5426073 Kd 190.0 nM
CN1C(=O)[C@@H](NC(=O)c2cc3cccc(-c4ccccc4F)c3[nH]2)COc2ccccc21 CHEMBL5394940 Kd 190.0 nM
CN1C(=O)[C@@H](NC(=O)c2cc3cccc(-c4cc(F)ccc4F)c3[nH]2)COc2ccccc21 CHEMBL5415575 Kd 190.0 nM
CCC(C)(C)C(=O)N(O)Cc1ccc(F)cc1F CHEMBL4091760 EC50 198.0 nM
Nc1ncnc2occ(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4F)cc3)c12 CHEMBL3109217 IC50 200.0 nM
O=C(N[C@H]1CCOc2ccccc2NC1=O)c1cc(Cc2ccccc2)on1 CHEMBL4098676 IC50 200.0 nM
Cc1cc(NC(=O)c2cccn(-c3ccc(F)cc3)c2=O)ccc1Oc1ccnc(NC(=O)C2CC2)c1 CHEMBL4476485 IC50 200.0 nM
C[C@@H]1C=NN(C(=O)C(C)(C)C)[C@@H]1c1ccccc1 CHEMBL4437641 IC50 200.0 nM
CC(=O)Nc1nc2ccc(-c3cnc(Cl)c(CC(=O)Cc4ccccc4)c3)cc2s1 CHEMBL4453780 IC50 200.0 nM
CN1C(=O)[C@@H](NC(=O)c2cc3cccc(-c4ccc(F)cc4F)c3[nH]2)COc2ccccc21 CHEMBL5408672 Kd 200.0 nM
O=C(NC1CC1)c1ccc(-c2cc3cccnc3[nH]2)cc1 CHEMBL5421764 IC50 200.0 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 210.0 nM
CN1C(=O)[C@@H](NC(=O)c2cc(Cc3ccccc3)on2)CCc2cc(C3(C(F)(F)F)N=N3)ccc21 CHEMBL3787617 IC50 210.0 nM
Oc1ccc(-c2cc3cccnc3[nH]2)cc1 CHEMBL4439426 Kd 218.0 nM
O=C(Cc1cccc(C(F)(F)F)n1)Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)sc3c2)ccc1F CHEMBL4575736 Kd 220.0 nM
CC(C)(C)Oc1ccc(-c2cc3cccnc3[nH]2)cc1 CHEMBL5408026 IC50 220.0 nM
CCC(C)(C)C(=O)N(C)Cc1cccs1 CHEMBL4096270 EC50 221.0 nM
CN1C(=S)[C@@H](NC(=O)c2n[nH]c(Cc3ccccc3)n2)COc2ccc(C#Cc3cccc([N+](=O)[O-])c3)cc21 CHEMBL5403329 Kd 230.0 nM
OCCc1ccc(-c2cc3cccnc3[nH]2)cc1 CHEMBL5407948 IC50 230.0 nM
Oc1ccc(-c2ccc(-c3cc4cccnc4[nH]3)cc2)cc1 CHEMBL5439801 IC50 230.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 240.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 240.0 nM
COc1cccc(CC(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)sc4c3)ccc2F)c1 CHEMBL4464579 Kd 240.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908842 Kd 240.0 nM
Nc1ccc(-c2cc3cccnc3[nH]2)cc1 CHEMBL5404353 IC50 240.0 nM
CN1C(=O)[C@@H](NC(=O)c2cc(CC3CCCCC3)on2)COc2ccccc21 CHEMBL4071135 IC50 251.0 nM
CN1C(=O)[C@@H](NC(=O)c2cccc(Cc3ccccc3)c2)COc2ccccc21 CHEMBL4098139 IC50 251.0 nM
CN1C(=O)[C@@H](N2CCc3nn(Cc4ccccc4)cc3C2=O)COc2ccccc21 CHEMBL4063075 pKi 251.19 nM
Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O CHEMBL477772 Kd 260.0 nM
CN1C(=O)[C@@H](NC(=O)c2cc3cccc(-c4cccc(F)c4F)c3[nH]2)COc2ccccc21 CHEMBL5411381 Kd 260.0 nM
CCC(C)(C)C(=O)N(O)Cc1ccc(F)c(F)c1F CHEMBL4099502 EC50 262.0 nM
Cn1nc(-c2ccc3c(c2)CCN3C(=O)Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2c(N)ncnc21 CHEMBL4284148 IC50 264.0 nM
CN1C(=S)[C@@H](NC(=O)c2nc(Cc3ccccc3)n(CC(F)(F)F)n2)COc2ccccc21 CHEMBL5181292 Kd 267.0 nM
Cc1ccccc1-c1cccc2cc(C(=O)N[C@H]3COc4ccccc4N(C)C3=O)[nH]c12 CHEMBL5433899 Kd 270.0 nM
O/N=C/c1ccc(-c2cc3cccnc3[nH]2)cc1 CHEMBL5409296 IC50 270.0 nM
CN1C(=S)[C@@H](NC(=O)c2nc(Cc3ccccc3)n(C3CCOC3)n2)COc2ccccc21 CHEMBL5181126 Kd 272.0 nM
Cc1cc(Nc2cc(N3CCCCC3)nc(Nc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL4069729 IC50 295.0 nM
CN1C(=S)[C@@H](NC(=O)c2nc(Cc3ccccc3)n(C3CCC3)n2)COc2ccccc21 CHEMBL5183211 Kd 301.0 nM
Nc1ccc(C#Cc2c(Oc3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)ccnc2N)nc1 CHEMBL4470115 IC50 310.0 nM
CC(C)(C)C(=O)N1CCCC1c1ccccc1 CHEMBL4584741 IC50 316.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 Kd 320.0 nM
CCCCCc1cc(C(=O)N[C@H]2COc3ccccc3NC2=O)n[nH]1 CHEMBL3786778 IC50 320.0 nM
CN1C(=O)NC(Cc2c[nH]c3c(Cl)cccc23)C1=O CHEMBL381230 IC50 320.0 nM
Cc1cccc(CC(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)sc4c3)ccc2F)c1 CHEMBL4444744 Kd 320.0 nM
c1cnc2[nH]c(-c3ccc4ncsc4c3)cc2c1 CHEMBL5436651 IC50 350.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 370.0 nM
C[C@H](NC(=O)c1ccc(C#N)n1C)c1c(F)cccc1Cl CHEMBL259796 IC50 370.0 nM
CCC(C)(C)C(=O)N(C)Cc1ccc(C)s1 CHEMBL4068805 EC50 378.0 nM
Cn1nc(-c2ccc3c(c2)CCN3C(=O)Cc2ccc(Br)cc2)c2c(N)ncnc21 CHEMBL4287519 IC50 392.0 nM
O=C(Nc1ccccc1)Nc1cccc(-c2c[nH]c3ncc(-c4ccccc4)cc23)c1 CHEMBL550273 IC50 400.0 nM
COc1cc(-c2nn(C)c3ncnc(N)c23)ccc1NC(=O)Cc1cccc(C(F)(F)F)c1 CHEMBL4293838 IC50 424.0 nM
CC1(C)C[C@@H]1C(=O)Nc1nc2ccc(Oc3ccc(F)c(NC(=O)Cc4cccc(C(F)(F)F)c4)c3)cc2s1 CHEMBL4850219 Kd 430.0 nM
COc1ccc2c(c1)C1=CN(C(=O)CO)[C@H](c3ccc(OC)c(F)c3)[C@@H]1CC2 CHEMBL5198153 IC50 440.0 nM
O=C(c1cnn(Cc2ccccc2)c1)N1CCOc2ccccc2C1 CHEMBL5176721 IC50 450.0 nM
CCC(C)(C)C(=O)N(C)Cc1ccccc1 CHEMBL4082828 EC50 457.0 nM
CCOc1ccccc1CNCC(=O)c1cn2ccc(-c3ccn4nc(NC(=O)C(C)C)nc4c3)cc2n1 CHEMBL5438972 IC50 463.0 nM
Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2cncnc21 CHEMBL4280312 IC50 468.0 nM
CC1(C)CC1C(=O)Nc1nc2ccc(Oc3ccc(F)c(NC(=O)Cc4cccc(C(F)(F)F)c4)c3)cc2s1 CHEMBL4860842 Kd 480.0 nM
CN(Cc1cc(F)cc(F)c1F)C(=O)C1(C)CCCCC1 CHEMBL4084908 EC50 490.0 nM
O=C(Nc1cccc(-c2c[nH]c3ncc(-c4ccccc4)cc23)c1)NC1CCCC1 CHEMBL3109208 IC50 500.0 nM
CC(C)NC(=O)c1ccc(-c2cc3cccnc3[nH]2)cc1 CHEMBL5422041 IC50 500.0 nM
O=C(Cc1cccc(C(F)(F)F)c1F)Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)sc3c2)ccc1F CHEMBL4553409 Kd 510.0 nM
O=C(CCc1cccc(C(F)(F)F)c1)Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)sc3c2)ccc1F CHEMBL4439279 Kd 510.0 nM
CC(C)c1cc(-c2nn(C)c3ncnc(N)c23)ccc1NC(=O)Cc1cccc(C(F)(F)F)c1 CHEMBL4278688 IC50 531.0 nM
CN1C(=O)[C@@H](NC(=O)c2nnc3ccc(C(F)(F)F)nn23)COc2ccccc21 CHEMBL4790658 Ki(app) 570.0 nM
O=C(Cc1ccc(F)c(C(F)(F)F)c1)Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)sc3c2)ccc1F CHEMBL4438227 Kd 590.0 nM
CC#Cc1c(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)ccnc1N CHEMBL4552106 IC50 600.0 nM
O=C(c1ccc2cc[nH]c2c1)N1CCC2(CC1)CCN(Cc1cc(F)ccc1F)C2=O CHEMBL5177216 IC50 624.0 nM
CCC(C)(C)C(=O)N(C)Cc1ccc(F)cc1F CHEMBL4087013 EC50 627.0 nM
CCC(C)(C)C(=O)N(C)Cc1ccco1 CHEMBL4076266 EC50 628.0 nM
CCC(C)(C)C(=O)N(C)Cc1cccc(Cl)c1 CHEMBL4078224 EC50 628.0 nM
Nc1nccc2c(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4Cl)cc3)cccc12 CHEMBL3109201 IC50 630.0 nM
CCCNC(=O)c1ccc(-c2cc3cccnc3[nH]2)cc1 CHEMBL5395362 IC50 630.0 nM
CN1C(=O)[C@@H](NC(=O)c2ncc(Cc3ccccc3)s2)COc2ccccc21 CHEMBL4088627 IC50 631.0 nM
Cn1nc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2cncnc21 CHEMBL4294339 IC50 634.0 nM
CN(Cc1cc(F)cc(F)c1F)C(=O)C1(C(F)(F)F)CCC1 CHEMBL4092663 EC50 656.0 nM
O=C(c1ccccc1)N1CCC2(CC1)CCN(Cc1cc(F)ccc1F)C2=O CHEMBL5187835 IC50 693.0 nM
Cn1nc(-c2ccc3c(c2)CCN3C(=O)Cc2ccc(Cl)cc2)c2c(N)ncnc21 CHEMBL4276878 IC50 704.0 nM
CN1C(=O)[C@@H](NC(=O)c2n[nH]c3c2CC(n2cccn2)CC3)COc2ccccc21 CHEMBL4758232 Ki(app) 750.0 nM
O=C(Cc1cccc([N+](=O)[O-])c1)Nc1cc(Oc2ccc3nc(NC(=O)C4CC4)sc3c2)ccc1F CHEMBL4590158 Kd 770.0 nM
N#Cc1cccc(CC(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)sc4c3)ccc2F)c1 CHEMBL4573380 Kd 780.0 nM
CN1C(=O)[C@@H](NC(=O)c2coc(Cc3ccccc3)n2)COc2ccccc21 CHEMBL4080047 IC50 794.0 nM
CCC(C)(C)C(=O)N(C)Cc1ccc(F)cc1 CHEMBL4080685 EC50 815.0 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 850.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCOCC5)ccc34)cc2)no1 CHEMBL576982 Kd 890.0 nM
CCC(C)(C)C(=O)NCc1ccccc1F CHEMBL4090332 EC50 898.0 nM
CN1C(=O)[C@@H](NC(=O)c2n[nH]c3c2CC2CC2C3)COc2ccccc21 CHEMBL4753759 Ki(app) 920.0 nM
Oc1ccccc1-c1cc2cccnc2[nH]1 CHEMBL5432668 IC50 950.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM