Clc1cc2cc(c1)-c1cnn3ccc(nc13)NCCOCCO2 CHEMBL4531690 IC50 0.011 nM
CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)c2cnc(N3CCN(CCCOc4cc5ncnc(Nc6n[nH]c(C)c6C)c5cc4S(=O)(=O)C(C)(C)C)CC3)cn2)CC[C@H]2CC[C@@H](C(=O)N[C@@H]3CCCc4ccccc43)N2C1=O CHEMBL4857880 pIC50 0.1 nM
CN[C@H](C)C(=O)N[C@@H](C(=O)N1C[C@@H](NC(=O)c2cnc(N3CCN(CCCOc4cc5ncnc(Nc6n[nH]c(C)c6C)c5cc4S(=O)(=O)C(C)(C)C)CC3)cn2)C[C@H]1c1nc(C(=O)c2ccc(F)cc2)cs1)C(C)(C)C CHEMBL4866182 pIC50 0.1585 nM
Cc1ccc(-c2cn([C@H]3CC[C@@H](N)CC3)c3ncnc(N)c23)c(F)c1 CHEMBL5177284 Kd 0.28 nM
CC(C)(C)S(=O)(=O)c1cc2c(Nc3ccc4scnc4c3)ncnc2cc1OCCOP(=O)(O)O CHEMBL4596287 Kd 0.78 nM
Nc1ncnc2c1c(-c1ccc3c(c1)OCO3)cn2[C@H]1CC[C@@H](N)CC1 CHEMBL5187454 IC50 0.8 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12 CHEMBL400402 Kd apparent 0.9 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1171837 IC50 1.0 nM
COc1cc2nccc(Nc3n[nH]c(C)c3C)c2cc1S(=O)(=O)C(C)(C)C CHEMBL4293287 IC50 1.3 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOc2cc3nccc(Nc4ccc5scnc5c4)c3cc2S(=O)(=O)C(C)(C)C)C(C)(C)C)cc1 CHEMBL4098772 DC50 1.4 nM
CCOc1cc2nccc(Nc3n[nH]c(C)c3C)c2cc1S(=O)(=O)C(C)(C)C CHEMBL4282034 IC50 1.6 nM
Nc1ncnc2c1c(-c1ccc(F)cc1)cn2[C@H]1CC[C@@H](N)CC1 CHEMBL5195615 IC50 1.6 nM
CC[C@@H](NC(=O)[C@@H]1C[C@H](NC(=O)COCCOCCOCCOCCOc2cc3nccc(Nc4ccc5scnc5c4)c3cc2S(=O)(=O)C(C)(C)C)CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)c1ccccc1 CHEMBL4856422 pIC50 1.995 nM
CN1CCN(CCOc2cc(OC3CCOCC3)c3c(Nc4c(Cl)ccc5c4OCO5)ncnc3c2)CC1 CHEMBL217092 Kd apparent 2.0 nM
COc1cc2ncc(-c3cc(Cl)cc(NC(C)=O)c3)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4176853 IC50 2.0 nM
CC(C)(C)S(=O)(=O)c1cc2c(Nc3ccc4scnc4c3)ncnc2cc1OCCO CHEMBL4514780 IC50 2.0 nM
COCC[n+]1c2c(n(Cc3cnccn3)c1C)C(=O)c1ccccc1C2=O CHEMBL2105734 IC50 2.0 nM
Cc1ccc(-c2cn([C@H]3CC[C@@H](N)CC3)c3ncnc(N)c23)cc1 CHEMBL5171377 IC50 2.4 nM
Cc1[nH]nc(Nc2ccnc3cc(OCCO)c(S(=O)(=O)C(C)(C)C)cc23)c1C CHEMBL4289904 IC50 2.5 nM
COCCOc1cc2nccc(Nc3n[nH]c(C)c3C)c2cc1S(=O)(=O)C(C)(C)C CHEMBL4292228 IC50 2.5 nM
CCc1cc2nccc(Nc3n[nH]c(C)c3C)c2cc1S(=O)(=O)C(C)(C)C CHEMBL4285837 IC50 2.5 nM
Cc1ccc(O)cc1Nc1ccnc2ccc(S(C)(=O)=O)cc12 CHEMBL237347 IC50 3.0 nM
CCOc1cc2ncc(-c3cc(N)nc(F)c3)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4171924 IC50 3.0 nM
CCOc1cc2ncc(-c3cc(N)nc(F)c3)n2cc1S(=O)(=O)C(C)C CHEMBL4161327 IC50 3.0 nM
COc1ccc(-c2cn([C@H]3CC[C@@H](NCc4ccccc4)CC3)c3ncnc(N)c23)cc1 CHEMBL5197634 IC50 3.0 nM
O=S1(=O)C=C(C2CC2)c2cc3ncnc(Nc4ccc5scnc5c4)c3cc21 CHEMBL5279908 Kd 3.3 nM
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 CHEMBL939 IC50 3.8 nM
COc1ccc(-c2cn([C@H]3CC[C@@H](NC(=O)c4cc(OC)c(OC)c(OC)c4)CC3)c3ncnc(N)c23)cc1 CHEMBL5205764 IC50 3.9 nM
COc1cc2ncnc(Nc3ccc4scnc4c3)c2cc1S(=O)(=O)C(C)(C)C CHEMBL4473105 IC50 4.0 nM
Nc1ccc(-c2cn([C@H]3CC[C@@H](N)CC3)c3ncnc(N)c23)cc1F CHEMBL5205532 IC50 4.0 nM
COc1ccc(-c2cn([C@H]3CC[C@@H](N)CC3)c3ncnc(N)c23)cc1 CHEMBL5174069 IC50 4.2 nM
COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 CHEMBL24828 Kd 4.6 nM
CC(C)(C)S(=O)(=O)c1ccc2nccc(Nc3n[nH]c4ccc(F)cc34)c2c1 CHEMBL3823499 IC50 5.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 5.0 nM
COc1cc2ncc(-c3ccc(O)c(Cl)c3)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4160817 IC50 5.0 nM
CCOc1cc2ncc(-c3cc(N)nc(Cl)c3)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4161723 IC50 5.0 nM
COCCOc1cc2ncc(-c3cc(N)nc(Cl)c3)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4173493 IC50 5.0 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(CC(C)C)c3n2)cc1 CHEMBL4847211 IC50 5.0 nM
CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(C(=O)c2ccc(F)cc2)cs1)C1CCN(C(=O)COCCOCCOCCOCCOc2cc3nccc(Nc4ccc5scnc5c4)c3cc2S(=O)(=O)C(C)(C)C)CC1 CHEMBL4872212 pIC50 5.012 nM
C=CCN[C@H]1CC[C@@H](n2cc(-c3ccc(OC)cc3)c3c(N)ncnc32)CC1 CHEMBL5171074 IC50 5.2 nM
Nc1ncnc2c1c(-c1cccc(Cl)c1)cn2[C@H]1CC[C@@H](N)CC1 CHEMBL5169942 IC50 5.9 nM
CCOC1=CS(=O)(=O)c2cc3c(Nc4ccc5scnc5c4)ncnc3cc21 CHEMBL5267954 Kd 5.9 nM
COc1cc2ncc(-c3cc(N)nc(Cl)c3)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4166239 IC50 6.0 nM
Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3cccc(S(C)(=O)=O)c3)nc21 CHEMBL4864600 IC50 6.0 nM
Oc1cc(Nc2ccnc3cc(-c4ccccc4)ccc23)ccc1Cl CHEMBL4873767 IC50 6.0 nM
COCCNC(=O)c1cc(CNc2ccc(Cl)c(O)c2)cc(-c2ccc3c(Nc4ccc(Cl)c(O)c4)ccnc3c2)c1 CHEMBL4869572 IC50 6.0 nM
CCCC(=O)N[C@H]1CC[C@@H](n2cc(-c3ccc(OC)cc3)c3c(N)ncnc32)CC1 CHEMBL5187179 IC50 6.0 nM
CS(=O)(=O)c1cccc(Nc2nccc(-c3sc(N4CCOCC4)nc3-c3cccc(NS(=O)(=O)c4c(F)cccc4F)c3)n2)c1 CHEMBL3628627 IC50 6.3 nM
CS(=O)(=O)c1ccc2nccc(Nc3ccc4scnc4c3)c2c1 CHEMBL3822791 IC50 6.3 nM
Cc1[nH]nc(Nc2ccnc3ccc(S(=O)(=O)C(C)(C)C)cc23)c1C CHEMBL4285462 IC50 6.3 nM
Cc1[nH]nc(Nc2ccnc3cc(OC(F)(F)F)c(S(=O)(=O)C(C)(C)C)cc23)c1C CHEMBL4281602 IC50 6.3 nM
Nc1ncnc2c1c(-c1ccc(O)cc1)cn2[C@H]1CC[C@@H](N)CC1 CHEMBL5184606 IC50 6.3 nM
CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)c2cnc(N3CCN(CCCOc4cc5ncnc(Nc6n[nH]c(C)c6C)c5cc4S(=O)(=O)C(C)(C)C)CC3)cn2)CC[C@H]2CC[C@@H](C(=O)NC3CCCc4ccccc43)N2C1=O CHEMBL4848861 pIC50 6.31 nM
Nc1ncnc2c1c(-c1cccc(F)c1)cn2[C@H]1CC[C@@H](N)CC1 CHEMBL5180091 IC50 6.4 nM
COc1ccc(-c2cn([C@H]3CC[C@@H](NCC#N)CC3)c3ncnc(N)c23)cc1 CHEMBL5175396 IC50 6.7 nM
C=CC(=O)N1CCC[C@H](n2c(=O)n(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL3991931 Kd apparent 7.0 nM
CC(C)Oc1cc2ncc(-c3cc(N)nc(Cl)c3)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4170048 IC50 7.0 nM
CC(C)(C)S(=O)(=O)c1cn2c(-c3cc(N)nc(Cl)c3)cnc2cc1OCC(F)(F)F CHEMBL4159424 IC50 7.0 nM
Cc1ccccc1-c1cn([C@H]2CC[C@@H](N)CC2)c2ncnc(N)c12 CHEMBL5191232 IC50 7.9 nM
CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(C(=O)c2ccc(F)cc2)cs1)C1CCN(C(=O)c2cnc(N3CCN(CCCOc4cc5ncnc(Nc6n[nH]c(C)c6C)c5cc4S(=O)(=O)C(C)(C)C)CC3)nc2)CC1 CHEMBL4864469 pIC50 7.943 nM
Cc1[nH]nc(Nc2ncnc3cc(OCCCN4CCN(C(=O)c5cnc(N6CCN(C[C@H]7CN[C@H](C)CN7CC(=O)N7CC(C)(C)c8c7cc(Cc7ccc(F)cc7)c(=O)n8C)[C@H](C)C6)nc5)CC4)c(S(=O)(=O)C(C)(C)C)cc23)c1C CHEMBL4870089 pIC50 7.943 nM
Cc1ccc(O)cc1Nc1ccnc2ccc(C(F)(F)F)cc12 CHEMBL3822938 IC50 8.0 nM
CN1CCN(CCOc2cc3ncc(-c4cc(N)nc(Cl)c4)n3cc2S(=O)(=O)C(C)(C)C)CC1 CHEMBL4162788 IC50 8.0 nM
Cn1c(=O)c(-c2ccccc2Cl)cc2cnc(Nc3cccc(S(C)(=O)=O)c3)nc21 CHEMBL4861488 IC50 8.0 nM
CC1=C(C)S(=O)(=O)c2cc3c(Nc4ccc5scnc5c4)ncnc3cc21 CHEMBL5274652 Kd 8.2 nM
COc1cc2ncc(-c3cc(O)cc(Cl)c3)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4164217 IC50 9.0 nM
Nc1ncnc2c1c(-c1ccccc1)cn2[C@H]1CC[C@@H](N)CC1 CHEMBL5207306 IC50 9.0 nM
C[S+]([O-])c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL10 IC50 10.0 nM
Cc1ccc(O)cc1Nc1ccnc2ccc(-c3cccnc3)cc12 CHEMBL237345 IC50 10.0 nM
CC(C)S(=O)(=O)c1ccc2nccc(Nc3n[nH]c4ccc(F)cc34)c2c1 CHEMBL3822577 IC50 10.0 nM
CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(OCCOCCOCCOCCOc3cc4nccc(Nc5ccc6scnc6c5)c4cc3S(=O)(=O)C(C)(C)C)ccc2C[C@@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C CHEMBL4863839 pIC50 10.0 nM
CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(C(=O)c2ccc(F)cc2)cs1)C1CCN(C(=O)c2cnc(N3CCC(COc4cc5ncnc(Nc6n[nH]c(C)c6C)c5cc4S(=O)(=O)C(C)(C)C)CC3)nc2)CC1 CHEMBL4860212 pIC50 10.0 nM
CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(C(=O)c2ccc(F)cc2)cs1)C1CCN(C(=O)c2ccc(N3CCN(CCCOc4cc5ncnc(Nc6n[nH]c(C)c6C)c5cc4S(=O)(=O)C(C)(C)C)CC3)nc2)CC1 CHEMBL4866917 pIC50 10.0 nM
CN[C@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)c2cnc(N3CCN(CCCOc4cc5ncnc(Nc6n[nH]c(C)c6C)c5cc4S(=O)(=O)C(C)(C)C)CC3)cn2)C[C@H]1C(=O)Nc1c(F)cccc1F)C(C)(C)C CHEMBL4863259 pIC50 10.0 nM
O=S1(=O)C=C(C2CC2)c2cc3ncnc(Nc4n[nH]c5ccc(F)cc45)c3cc21 CHEMBL5277405 Kd 10.0 nM
Cc1[nH]nc(Nc2ncnc3cc4c(cc23)S(=O)(=O)C=C4C2CC2)c1C CHEMBL5286467 Kd 10.0 nM
O=S1(=O)C=C(C2CC2)c2cc3ncnc(Nc4ccc5nn[nH]c5c4)c3cc21 CHEMBL5286856 Kd 10.0 nM
C=C([C@@H](NC(=O)COCCOCCOCCOCCOc1cc2nccc(Nc3ccc4scnc4c3)c2cc1S(=O)(=O)C(C)(C)C)C(C)(C)C)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1 CHEMBL5437324 IC50 10.0 nM
Cc1ccc(C(=O)Nc2cccc(-c3nccn3C)c2)cc1NC(=O)c1ccccc1 CHEMBL5394595 IC50 10.0 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4)c(=O)n(C)c3n2)cc1 CHEMBL136244 IC50 10.5 nM
Cc1cccc(-c2cn([C@H]3CC[C@@H](N)CC3)c3ncnc(N)c23)c1 CHEMBL5174176 IC50 10.7 nM
CCC(=O)N[C@H]1CC[C@@H](n2cc(-c3ccc(OC)cc3)c3c(N)ncnc32)CC1 CHEMBL5191796 IC50 10.8 nM
COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(N)=O CHEMBL1289601 Kd apparent 11.0 nM
COc1cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)ccc1O CHEMBL4168738 IC50 11.0 nM
CCCS(=O)(=O)Nc1cc(-c2cc(-c3cccc(N4CCNCC4)c3)cnc2N)cc(F)c1OC CHEMBL4799077 IC50 11.0 nM
COc1ccc(-c2cc3cnc(Nc4cccc(S(C)(=O)=O)c4)nc3n(C)c2=O)cc1 CHEMBL4861447 IC50 11.0 nM
COc1ccc(-c2cn([C@H]3CC[C@@H](NC(C)=O)CC3)c3ncnc(N)c23)cc1 CHEMBL5189173 IC50 11.7 nM
COCCNC(=O)c1ccc2c(c1)nc(-c1cnc(-c3ccc(Cl)cc3)[nH]1)n2CCOC CHEMBL3628628 IC50 12.0 nM
CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(C(=O)c2ccc(F)cc2)cs1)C1CCN(C(=O)c2cnc(N3CCN(CCCOc4cc5ncnc(Nc6n[nH]c(C)c6C)c5cc4S(=O)(=O)C(C)(C)C)CC3)cn2)CC1 CHEMBL4876228 pIC50 12.59 nM
CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@@H](NC(=O)c2cnc(N3CCN(CCCOc4cc5ncnc(Nc6n[nH]c(C)c6C)c5cc4S(=O)(=O)C(C)(C)C)CC3)cn2)CC1C(=O)NC1CCCc2ccccc21)C(C)(C)C CHEMBL4845683 pIC50 12.59 nM
COc1cc(NS(=O)(=O)C(C)C)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)c1 CHEMBL4781705 IC50 13.0 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 CHEMBL49120 IC50 13.0 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccc(Cl)cc4)c(=O)n(C)c3n2)cc1 CHEMBL4852860 IC50 13.0 nM
CCCS(=O)(=O)Nc1cc(OC)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)c1 CHEMBL4800115 IC50 14.0 nM
Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3ccc(S(C)(=O)=O)cc3)nc21 CHEMBL4868894 IC50 14.0 nM
CC1=CS(=O)(=O)c2cc3c(Nc4ccc5scnc5c4)ncnc3cc21 CHEMBL5274710 Kd 14.0 nM
O=S1(=O)C=C(C2CC2)c2cc3ncnc(Nc4cc(O)ccc4F)c3cc21 CHEMBL5277359 Kd 14.0 nM
c1cc2cc(n1)NCCOCCNc1ccn3ncc-2c3n1 CHEMBL5402906 IC50 14.1 nM
Cn1c(=O)c(-c2ccc(Cl)cc2)cc2cnc(Nc3cccc(S(C)(=O)=O)c3)nc21 CHEMBL4864714 IC50 14.6 nM
Cc1ccc(-c2cc3cnc(Nc4cccc(S(C)(=O)=O)c4)nc3n(C)c2=O)c(Cl)c1 CHEMBL4875011 IC50 15.0 nM
COc1ccc(-c2cn([C@H]3CC[C@@H](NC(=O)C(C)(C)C)CC3)c3ncnc(N)c23)cc1 CHEMBL5172982 IC50 15.6 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 16.0 nM
COc1cc2ncc(-c3ccc(O)cc3)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4163484 IC50 16.0 nM
CCCS(=O)(=O)Nc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)cc(F)c1OC CHEMBL4789724 IC50 16.0 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccc(Cl)cc4Cl)c(=O)n(C)c3n2)cc1 CHEMBL4849134 IC50 16.0 nM
Cn1c(=O)c(-c2ccc(O)cc2)cc2cnc(Nc3cccc(S(C)(=O)=O)c3)nc21 CHEMBL4867467 IC50 16.0 nM
c1ccc(-c2ccc3c(Nc4ccc5scnc5c4)ccnc3c2)cc1 CHEMBL4876135 IC50 16.0 nM
COc1ccc(-c2cn([C@H]3CC[C@@H](NC(=O)C(C)Cl)CC3)c3ncnc(N)c23)cc1 CHEMBL5204246 IC50 16.7 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4c(F)cccc4F)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4462318 Kd(free) 17.0 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4Cl)c(=O)n(C)c3n2)cc1 CHEMBL4853179 IC50 17.0 nM
Cn1c(=O)c(-c2ccc(F)cc2Cl)cc2cnc(Nc3cccc(S(C)(=O)=O)c3)nc21 CHEMBL4867716 IC50 17.0 nM
CC(C)Oc1cc(NS(=O)(=O)C(C)C)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)c1 CHEMBL4792496 IC50 18.0 nM
COc1ccc(-c2cn([C@H]3CC[C@@H](NCc4cccc(OC(F)(F)F)c4)CC3)c3ncnc(N)c23)cc1 CHEMBL5170201 IC50 18.5 nM
CC(C)(C)n1nc(-c2ccc(Cl)cc2)c2c(N)ncnc21 CHEMBL406845 IC50 19.0 nM
COc1cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)cc(OC(F)F)c1C(=O)NC1CC1 CHEMBL5417444 IC50 19.7 nM
Cc1ccc(O)cc1Nc1ccnc2ccc(C(=O)NCC3CCOCC3)cc12 CHEMBL3824056 IC50 20.0 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL5416410 Kd apparent 20.0 nM
COc1cc2ncc(-c3ccc4[nH]ncc4c3)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4167668 IC50 20.0 nM
CCCS(=O)(=O)Nc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)cc(OC)c1OC CHEMBL4781373 IC50 20.0 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 21.0 nM
COc1cc2ncc(-c3cccc(NC(C)=O)c3)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4171039 IC50 21.0 nM
CCOc1cc(NS(=O)(=O)C(C)C)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)c1 CHEMBL4795976 IC50 21.0 nM
CCCS(=O)(=O)Nc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)cc(Cl)c1OC CHEMBL4793153 IC50 21.0 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccc(OC)cc4)c(=O)n(C)c3n2)cc1 CHEMBL4852513 IC50 21.0 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(Cc4ccccc4)c3n2)cc1 CHEMBL4858463 IC50 21.0 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(Cc4ccc(S(C)(=O)=O)cc4)c3n2)cc1 CHEMBL4874031 IC50 21.0 nM
COc1ccc(-c2cn([C@H]3CC[C@@H](NS(=O)(=O)C(F)(F)F)CC3)c3ncnc(N)c23)cc1 CHEMBL5185309 IC50 21.1 nM
Cn1c(=O)c(-c2cc(Cl)ccc2Cl)cc2cnc(Nc3cccc(S(C)(=O)=O)c3)nc21 CHEMBL4853711 IC50 22.0 nM
COc1cc(NS(=O)(=O)c2ccccc2)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)c1 CHEMBL4776631 IC50 23.0 nM
COc1cc2ncc(C(=O)Nc3ccccc3C)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4162913 IC50 24.0 nM
CCOC1=C(C)S(=O)(=O)c2cc3c(Nc4ccc5scnc5c4)ncnc3cc21 CHEMBL5287768 Kd 24.0 nM
NC(=O)c1c(-c2ccc3scnc3c2)nn2c1NCCCCC2 CHEMBL4475766 IC50 25.0 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccc(O)cc4)c(=O)n(C)c3n2)cc1 CHEMBL4870434 IC50 25.0 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(Cc4cccc(S(C)(=O)=O)c4)c3n2)cc1 CHEMBL4864576 IC50 25.0 nM
c1ccc2c(-c3cnn4cc(-c5ccc(N6CCNCC6)cc5)cnc34)ccnc2c1 CHEMBL513147 IC50 25.0 nM
Cc1[nH]nc(Nc2ncnc3cc(OCCCN4CCN(C(=O)c5cnc(N6CCN(C[C@H]7CN[C@H](C)CN7CC(=O)N7CC(C)(C)c8ncc(Cc9ccc(F)cc9)cc87)[C@H](C)C6)nc5)CC4)c(S(=O)(=O)C(C)(C)C)cc23)c1C CHEMBL4860242 pIC50 25.12 nM
COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC CHEMBL97771 IC50 26.0 nM
Cc1ccc(-c2nn(C(C)(C)C)c3ncnc(N)c23)cc1 CHEMBL306380 IC50 26.0 nM
CCCS(=O)(=O)Nc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2)cc(F)c1OC CHEMBL4782505 IC50 27.0 nM
Cn1c(=O)c(-c2ccc(Cl)cc2Cl)cc2cnc(Nc3cccc(S(C)(=O)=O)c3)nc21 CHEMBL4859351 IC50 27.0 nM
COC1=CS(=O)(=O)c2cc3c(Nc4ccc5scnc5c4)ncnc3cc21 CHEMBL5271765 Kd 27.0 nM
COc1cc2ncc(-c3ccnc(N)c3)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4173646 IC50 29.0 nM
NC(=O)c1c(-c2ccc3scnc3c2)nn2c1N[C@H]1C[C@H](C[C@@H]1O)C2 CHEMBL4527824 IC50 30.0 nM
CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(C(=O)c2ccc(F)cc2)cs1)C1CCN(C(=O)c2cnc(N3CCC(CCCOc4cc5ncnc(Nc6n[nH]c(C)c6C)c5cc4S(=O)(=O)C(C)(C)C)CC3)nc2)CC1 CHEMBL4864095 pIC50 31.62 nM
CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(C(=O)c2ccc(F)cc2)cs1)C1CCN(C(=O)c2ccc(N3CCN(CCCOc4cc5ncnc(Nc6n[nH]c(C)c6C)c5cc4S(=O)(=O)C(C)(C)C)CC3)cc2)CC1 CHEMBL4857717 pIC50 31.62 nM
CCCS(=O)(=O)Nc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)ccc1OC CHEMBL4786742 IC50 32.0 nM
COc1cc2c(Nc3ccc(Cl)c(Cl)c3F)ncnc2cc1OC[C@@H]1C[C@@H]2CN(C)C[C@@H]2C1 CHEMBL3544983 Kd apparent 33.0 nM
Cc1ccc(-c2nn(C(C)(C)CNC(=O)c3ccncc3)c3ncnc(N)c23)cc1 CHEMBL5206121 IC50 33.8 nM
Cn1c(=O)c(-c2cccc(Cl)c2Cl)cc2cnc(Nc3cccc(S(C)(=O)=O)c3)nc21 CHEMBL4847571 IC50 34.0 nM
COc1cc2ncc(-c3cccc(O)c3)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4174187 IC50 35.0 nM
Cc1cccc(-c2nn3c(c2-c2ccnc4ccc(C(N)=O)cc24)CCC3)n1 CHEMBL2364611 Kd apparent 38.0 nM
COc1cc2ncc(C(=O)Oc3ccccc3C)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4170854 IC50 38.0 nM
COc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)cc(F)c1OC CHEMBL4781201 IC50 39.0 nM
CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(C(=O)c2ccc(F)cc2)cs1)C1CCN(C(=O)c2cnc(N3CCC(CCOc4cc5ncnc(Nc6n[nH]c(C)c6C)c5cc4S(=O)(=O)C(C)(C)C)CC3)nc2)CC1 CHEMBL4851924 pIC50 39.81 nM
COc1cccc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)c1 CHEMBL4160116 IC50 40.0 nM
COc1cc2ncc(-c3ccnc(NC(C)=O)c3)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4165728 IC50 40.0 nM
CC(C)(C)n1nc(-c2ccc3scnc3c2)c(C(N)=O)c1N CHEMBL4437124 IC50 40.0 nM
Nc1c(-c2ccc(F)cc2)c(-c2ccncc2)nn1-c1c(Cl)cc(Cl)cc1Cl CHEMBL2011291 IC50 41.0 nM
CCCS(=O)(=O)Nc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)cc(C)c1OC CHEMBL4788375 IC50 41.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1 CHEMBL1946170 IC50 41.0 nM
COc1cc2nccc(Nc3cc(OC)c(OC)c(OC)c3)c2cc1OC CHEMBL311959 Kd 42.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4cc(F)ccc4F)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4443828 Kd(free) 43.0 nM
COc1cc(Cl)cc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)c1 CHEMBL4172092 IC50 45.0 nM
C=CC(=O)N1CCC(Oc2cc3c(Nc4ccc(Cl)c(Cl)c4F)ncnc3cc2OC)CC1 CHEMBL3545154 Kd apparent 48.0 nM
CS(=O)(=O)c1ccc2nccc(Nc3ccc4[nH]nnc4c3)c2c1 CHEMBL3823809 IC50 50.0 nM
CS(=O)(=O)c1ccc2nccc(Nc3n[nH]c4ccc(F)cc34)c2c1 CHEMBL3822754 IC50 50.0 nM
CCn1nc(-c2ccc3scnc3c2)c(C(N)=O)c1N CHEMBL4561931 IC50 50.0 nM
NC(=O)c1c(-c2ccc3scnc3c2)nn2c1N[C@@H]1CC[C@@H](C1)C2 CHEMBL4551566 IC50 50.0 nM
Cc1ccc(COC(=O)Nc2cc(-c3cc4c([nH]3)CCNC4=O)ccn2)cc1 CHEMBL4434926 IC50 50.0 nM
COc1cc(NS(C)(=O)=O)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)c1 CHEMBL4784430 IC50 51.0 nM
Cc1cccc(-c2[nH]c(CNc3ccccc3F)nc2-c2ccc3ncnn3c2)n1 CHEMBL3260567 IC50 54.0 nM
CCCS(=O)(=O)Nc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)ccc1O CHEMBL4786295 IC50 54.0 nM
CC1=Cc2cc3ncnc(Nc4ccc5scnc5c4)c3cc2S1(=O)=O CHEMBL5276428 Kd 55.0 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL1873475 Kd apparent 57.0 nM
COc1n[nH]c2ncc(-c3cn(-c4c(F)ccc(NS(=O)(=O)c5cccc(-c6ccccc6)c5)c4F)nn3)cc12 CHEMBL4450810 Kd 57.0 nM
CC(C)(C)S(=O)(=O)c1cn2c(-c3cc(N)nc(Cl)c3)cnc2cc1OC1CC1 CHEMBL4169652 IC50 58.0 nM
CC(C)(C)n1nc(-c2ccc3ccccc3c2)c(C(N)=O)c1N CHEMBL3108912 IC50 60.0 nM
CCn1nc(-c2ccc3scnc3c2)c(C(N)=O)c1NC CHEMBL4475515 IC50 60.0 nM
NC(=O)c1c(-c2ccc3scnc3c2)nn2c1NCCCC2 CHEMBL4535795 IC50 60.0 nM
NC(=O)c1c(-c2ccc3scnc3c2)nn2c1N[C@@H]1C[C@@H](C[C@H]1O)C2 CHEMBL4453606 IC50 60.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccncc3)cc2)no1 CHEMBL166031 IC50 63.0 nM
CC(C)Cn1c(=O)c(-c2ccc(Cl)cc2)cc2cnc(Nc3cccc(S(C)(=O)=O)c3)nc21 CHEMBL4856366 IC50 64.7 nM
COc1cc(Nc2ccnc3ccc(I)cc23)cc(OC)c1OC CHEMBL4517424 Kd 69.0 nM
COc1cc2ncc(-c3ccc(C(N)=O)c(Cl)c3)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4165019 IC50 70.0 nM
Cc1ccc(O)cc1Nc1ncnc2cc3c(cc12)S(=O)(=O)C=C3C1CC1 CHEMBL5288133 Kd 70.0 nM
O=[N+]([O-])c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL17331 IC50 70.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1336 IC50 75.0 nM
COc1cc(NS(=O)(=O)C(C)C)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2C)c1 CHEMBL4792227 IC50 76.0 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 77.0 nM
CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1 CHEMBL2028663 IC50 77.0 nM
CCCS(=O)(=O)N1CCOc2ccc(-c3cc(-c4ccc(N5CCNCC5)cc4)cnc3N)cc21 CHEMBL4797951 IC50 78.0 nM
COc1cc(-c2cnc3cc(OCCN4CCOCC4)ccn23)cc2c1C(=O)N(CC(F)(F)F)CC2 CHEMBL5393771 IC50 78.4 nM
CC(C)(C)S(=O)(=O)c1ccc2nccc(Nc3n[nH]c4ncc(F)cc34)c2c1 CHEMBL4278565 IC50 79.0 nM
COc1cc(-c2nn(C(C)(C)C)c(N)c2C(N)=O)ccc1Cl CHEMBL4517939 IC50 80.0 nM
NC(=O)c1c(-c2ccc3scnc3c2)nn2c1N[C@H]1C[C@@H](C2)[C@H](O)C1 CHEMBL4562422 IC50 80.0 nM
COc1cc(Nc2ccnc3ccc(Cl)cc23)cc(OC)c1OC CHEMBL4556662 Kd 85.0 nM
COc1cc(Nc2ccnc3ccc(C#N)cc23)cc(OC)c1OC CHEMBL4585158 Kd 88.0 nM
COc1cc2ncc(-c3cccc(Cl)c3)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4166371 IC50 90.0 nM
COc1cc(Nc2ccnc3cc(C#N)ccc23)cc(OC)c1OC CHEMBL4575895 Kd 96.0 nM
CN1CCN(C2CCN(C(=O)Nc3cc(Oc4ccc(NC(=O)C5(C(=O)Nc6ccc(F)cc6)CC5)c(F)c4)ccn3)CC2)CC1 CHEMBL3039525 Kd apparent 97.0 nM
COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1 CHEMBL491473 Kd 98.0 nM
CCCS(=O)(=O)NCc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)ccc1OC CHEMBL4783273 IC50 99.0 nM
COc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2C)cc(OC)c1OC CHEMBL3341789 IC50 100.0 nM
CCCS(=O)(=O)Nc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)ccc1C CHEMBL4800562 IC50 102.0 nM
CCCS(=O)(=O)Nc1cc(-c2cc(-c3cccc(S(C)(=O)=O)c3)cnc2N)ccc1OC CHEMBL4780183 IC50 103.0 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccc(C(C)(C)C)cc4)c(=O)n(C)c3n2)cc1 CHEMBL4854929 IC50 105.0 nM
O=S1(=O)C=C(c2ccccc2)c2cc3ncnc(Nc4ccc5scnc5c4)c3cc21 CHEMBL5286275 Kd 109.0 nM
COc1cc(Nc2ccnc3ccc(Br)cc23)cc(OC)c1OC CHEMBL4443342 Kd 110.0 nM
Cc1cccc(-c2[nH]c(Cc3cccc(C(N)=O)c3)nc2-c2ccc3nccnc3c2)n1 CHEMBL492634 IC50 111.0 nM
CC(C)(C)n1nc(-c2cccc3ccccc23)c2c(N)ncnc21 CHEMBL264406 IC50 120.0 nM
COc1cc2ncc(-c3ccc4nc[nH]c4c3)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4160433 IC50 120.0 nM
CC(C)(C)n1nc(-c2ccc(Cl)c(Cl)c2)c(C(N)=O)c1N CHEMBL4562524 IC50 120.0 nM
CC(C)(C)n1nc(-c2ccc3cc[nH]c3c2)c(C(N)=O)c1N CHEMBL4482915 IC50 120.0 nM
CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(C(=O)c2ccc(F)cc2)cs1)C1CCN(C(=O)c2ccc(N3CCN(CCOc4cc5ncnc(Nc6n[nH]c(C)c6C)c5cc4S(=O)(=O)C(C)(C)C)CC3)nc2)CC1 CHEMBL4851311 pIC50 125.89 nM
Cc1cc(Nc2ccnc3ccc(S(=O)(=O)C(C)(C)C)cc23)n[nH]1 CHEMBL4283104 IC50 126.0 nM
CCS(=O)(=O)Nc1cc(OC)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2C)c1 CHEMBL4776443 IC50 127.0 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(CCOC)c3n2)cc1 CHEMBL4859716 IC50 128.0 nM
CC(C)(C)n1nc(Cc2cccc3ccccc23)c2c(N)ncnc21 CHEMBL573578 IC50 130.0 nM
COc1ccc(-c2cnc3cc(OC)c(S(=O)(=O)C(C)(C)C)cn23)cc1 CHEMBL4167365 IC50 130.0 nM
Oc1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL278041 Kd 150.0 nM
CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(C(=O)c2ccc(F)cc2)cs1)C1CCN(C(=O)COCCOCCOCCOCCOc2cc3ncnc(Nc4n[nH]c(C)c4C)c3cc2S(=O)(=O)C(C)(C)C)CC1 CHEMBL4872484 pIC50 158.49 nM
CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(C(=O)c2ccc(F)cc2)cs1)C1CCN(C(=O)c2cnc(N3CCN(CCOc4cc5ncnc(Nc6n[nH]c(C)c6C)c5cc4S(=O)(=O)C(C)(C)C)CC3)cn2)CC1 CHEMBL4861005 pIC50 158.49 nM
COc1cc2ncc(-c3ccc(C(N)=O)cc3)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4166930 IC50 160.0 nM
NC(=O)c1c(-c2ccc3scnc3c2)nn2c1N[C@@H]1C[C@H](C2)[C@@H](O)C1 CHEMBL4583311 IC50 160.0 nM
CCCS(=O)(=O)Nc1cc(OC)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2C)c1 CHEMBL4782562 IC50 164.0 nM
COc1ccc2nccc(Nc3cc(OC)c(OC)c(OC)c3)c2c1 CHEMBL4592501 Kd 170.0 nM
Cc1nc2cc(-c3nn(C(C)C)c4ncnc(N)c34)ccc2o1 CHEMBL3991933 Kd apparent 178.0 nM
COc1cc2ncc(-c3cccc(C#N)c3)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4175635 IC50 180.0 nM
COc1cc(Nc2ccnc3ccc(C(F)(F)F)cc23)cc(OC)c1OC CHEMBL535429 Kd 180.0 nM
CCCS(=O)(=O)N1CCc2ccc(-c3cc(-c4ccc(N5CCNCC5)cc4)cnc3N)cc21 CHEMBL4792038 IC50 185.0 nM
Cc1cc(-c2cc(OC(=O)c3ccccc3)ccc2Cl)cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12 CHEMBL403989 Kd apparent 192.0 nM
CNC(=O)c1cccc2cc(Oc3ccnc4cc(OCC5(N)CC5)c(OC)cc34)ccc12 CHEMBL2220486 Kd apparent 199.0 nM
COc1cc2ncc(-c3ccc4cn[nH]c4c3)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4175533 IC50 200.0 nM
COc1ccc2c(Nc3cc(OC)c(OC)c(OC)c3)ccnc2c1 CHEMBL4586530 Kd 200.0 nM
COc1ccc2nccc(Nc3cc(O)ccc3C)c2c1 CHEMBL3823527 IC50 250.0 nM
NC(=O)c1c(-c2ccc3scnc3c2)nn2c1NCCC2 CHEMBL4558980 IC50 250.0 nM
CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(C(=O)c2ccc(F)cc2)cs1)C1CCN(C(=O)c2cnc(N3CCN(CCOc4cc5ncnc(Nc6n[nH]c(C)c6C)c5cc4S(=O)(=O)C(C)(C)C)CC3)nc2)CC1 CHEMBL4878694 pIC50 251.19 nM
CCCS(=O)(=O)Nc1cc(-c2cc(-c3ccc(S(C)(=O)=O)cc3)cnc2N)ccc1OC CHEMBL4800323 IC50 264.0 nM
COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1 CHEMBL1908396 Kd 290.0 nM
COc1cc(NS(C)(=O)=O)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2C)c1 CHEMBL4779127 IC50 296.0 nM
C=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1 CHEMBL31965 Kd 300.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 317.0 nM
CNc1cc(Oc2c(F)cc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2F)ccn1 CHEMBL3822979 IC50 320.0 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 CHEMBL3301612 Kd apparent 323.0 nM
O=S1(=O)C=C(C2CC2)c2cc3ncnc(Nc4ccc5nc[nH]c5c4)c3cc21 CHEMBL5277132 Kd 325.0 nM
Nc1ncnc2c1c(-c1cccc(OCc3ccccc3)c1)cn2[C@H]1C[C@H](N2CCC2)C1 CHEMBL551064 Kd apparent 355.0 nM
COc1cc2ncnc3c2cc1OCCCCCN(C)Cc1ccc(Br)cc1N3 CHEMBL3109738 Kd apparent 390.0 nM
CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(OCCOCCOCCOCCOc3cc4ncnc(Nc5n[nH]c(C)c5C)c4cc3S(=O)(=O)C(C)(C)C)ccc2C[C@@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C CHEMBL4852345 pIC50 398.11 nM
C=CS(=O)(=O)N1CCC[C@@H]1Cn1cc(-c2ccc3c(c2)OCO3)c2c(N)ncnc21 CHEMBL4095253 IC50 403.1 nM
C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1 CHEMBL553 Kd 410.0 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(Cl)cc4)cc23)c1F CHEMBL1229517 Kd apparent 427.0 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F CHEMBL1230020 Kd 430.0 nM
COc1cc2ncc(-c3cccc(C(N)=O)c3)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4159032 IC50 430.0 nM
COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C(F)(F)F)on4)c3)c2cc1OC CHEMBL2029988 Kd apparent 442.0 nM
COc1ccccc1-c1cnc2cc(OC)c(S(=O)(=O)C(C)(C)C)cn12 CHEMBL4170760 IC50 460.0 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1 CHEMBL3301622 Kd apparent 482.0 nM
Nc1nc(N)c2nc(-c3cccc(O)c3)c(-c3cccc(O)c3)nc2n1 CHEMBL230011 Kd 500.0 nM
COc1cc2ncc(-c3ccc(Cl)cc3)n2cc1S(=O)(=O)C(C)(C)C CHEMBL4164029 IC50 520.0 nM
CCCS(=O)(=O)Nc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)cc2c1OCCO2 CHEMBL4789064 IC50 520.0 nM
COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL281948 Kd apparent 526.0 nM
O=S1(=O)C=C(c2ccc(F)cc2)c2cc3ncnc(Nc4ccc5scnc5c4)c3cc21 CHEMBL5279827 Kd 545.0 nM
Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O CHEMBL477772 Kd 580.0 nM
Cc1ccc(-c2ccc3c(ccc4sc5c(c43)NC[C@@H](C)NC5=O)n2)cn1 CHEMBL1231206 IC50 590.0 nM
CCn1cc(-c2ccnc3[nH]c(-c4cccc(CN(C)C)c4)cc23)c(-c2ccc(NC(=O)N(C)C)cc2)n1 CHEMBL1090479 Kd apparent 611.0 nM
Cc1ccc(O)cc1Nc1ccnc2ccccc12 CHEMBL3822573 IC50 630.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 640.0 nM
COc1cc(Nc2ccnc3ccc(C(C)(C)C)cc23)cc(OC)c1OC CHEMBL530635 Kd 670.0 nM
Cc1cc(NC(=O)c2cccn(-c3ccc(F)cc3)c2=O)ccc1Oc1ccnc(NC(=O)C2CC2)c1 CHEMBL4476485 IC50 680.0 nM
Cc1cccc(-c2[nH]c(C(C)(C)C)nc2-c2ccc3c(c2)OCO3)n1 CHEMBL226838 IC50 685.0 nM
CC1=Cc2cc3nc(C)nc(Nc4ccc5scnc5c4)c3cc2S1(=O)=O CHEMBL5290584 Kd 685.0 nM
Nc1nccc(-c2c(-c3ccc(F)cc3)ncn2C2CCNCC2)n1 CHEMBL274064 IC50 700.0 nM
CNC(=O)CN1CCC(Oc2cc3c(Nc4cccc(Cl)c4F)ncnc3cc2OC)CC1 CHEMBL2408045 Kd apparent 751.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC CHEMBL2105717 Kd apparent 767.0 nM
CC(C)(C)n1nc(-c2ccc3c(c2)OCO3)c(C(N)=O)c1N CHEMBL4568258 IC50 790.0 nM
CC(C)(C)n1nc(-c2ccc3nonc3c2)c(C(N)=O)c1N CHEMBL4461710 IC50 790.0 nM
CC(C)(C)S(=O)(=O)c1ccc2nccc(Nc3cc[nH]n3)c2c1 CHEMBL4293701 IC50 794.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC CHEMBL1289494 Kd apparent 801.0 nM
C[C@@H]1COC(Nc2ccc3ncnc(Nc4ccc(OCc5nccs5)c(Cl)c4)c3c2)=N1 CHEMBL2103842 Kd apparent 810.0 nM
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL601719 Kd 900.0 nM
Cn1c(Nc2ccc(C(F)(F)F)cc2)nc2cc(Oc3ccnc(-c4ncc(C(F)(F)F)[nH]4)c3)ccc21 CHEMBL558752 Kd 950.0 nM
NC(=O)c1c(OCc2c(F)cc(Br)cc2F)nsc1NC(=O)NCCCCN1CCCC1 CHEMBL253969 Kd apparent 958.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 970.0 nM
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN1CCCCC1 CHEMBL2110732 Kd apparent 988.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM
COC1=CC(=O)C(CC=C(C)C)(CC=C(C)C)C(=O)/C1=C(O)/C=C/c1ccccc1 CHEMBL5191750 Kd 1000.0 nM