Cc1n[nH]cc1-c1cc(OCCN(C)C)c(C(=O)N[C@H](C)c2ccccc2)cc1F CHEMBL4107027 IC50 0.2 nM
NC[C@@H](C(=O)Nc1ccc2cnccc2c1)c1ccc(CO)cc1 CHEMBL4753043 Ki 0.2 nM
COc1cc(C(=O)NCc2cccc(C(=O)Nc3nc4c(s3)CNCC4)c2)ccc1-c1cn[nH]c1 CHEMBL3902471 IC50 0.26 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 Kd 0.28 nM
COc1cc(C(=O)NCc2cccc(C(=O)Nc3nc4c(s3)CN(C)CC4)c2)ccc1-c1cn[nH]c1 CHEMBL3961538 IC50 0.39 nM
COc1cc(C(=O)NCc2cccc(C(=O)NC3CCN(C)CC3)c2)ccc1-c1cn[nH]c1 CHEMBL3949136 IC50 0.43 nM
COc1cccc([C@@H](C)NC(=O)c2ccc3c(c2)C(C)Oc2cnccc2-3)c1 CHEMBL4763198 IC50 0.49 nM
O=C(NCc1cccc(O)c1)Nc1nc(-c2ccncc2)cs1 CHEMBL3218297 IC50 0.53 nM
Cc1c[nH]c2nccc(Oc3c(F)cc(Nc4cc(Cl)nc(N)n4)cc3F)c12 CHEMBL1971943 IC50 0.6 nM
CCC1Oc2cnccc2-c2ccc(C(=O)N[C@H](C)c3cccc(OC)c3)cc21 CHEMBL3578252 IC50 0.63 nM
COc1cc(C(=O)N[C@H](CN)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4114628 IC50 0.77 nM
CCCOc1cccc(C(C)NC(=O)c2ccc(-c3ccncc3F)cc2)c1 CHEMBL1971606 pKi 0.7943 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 0.7943 nM
CCn1c(-c2nonc2N)nc2cncc(C(=O)N3CCC(N)C3)c21 CHEMBL1870106 pKi 0.7943 nM
CCc1cc(C(=O)N[C@H](C)c2cccc(OC)c2)ccc1-c1cn[nH]c1 CHEMBL4791701 IC50 0.8 nM
COc1cc(C(=O)NCc2cccc(O)c2)ccc1-c1cn[nH]c1 CHEMBL3986802 IC50 0.85 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)c1 CHEMBL3913336 IC50 0.9 nM
O=c1[nH]c([C@@H]2CNC[C@H]2c2ccc(Cl)cc2)nc2ccc(-c3cn[nH]c3)cc12 CHEMBL2333898 IC50 1.0 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3ccncc3)cc2)c1 CHEMBL4448806 IC50 1.0 nM
Cc1ccc(C(=O)OCc2ccc([C@@H](CN)C(=O)Nc3ccc4cnccc4c3)cc2)c(C)c1 CHEMBL4796289 Ki 1.0 nM
O=C(Cc1cccc(OCCCC2CCNCC2)c1)Nc1nc(-c2c[nH]c3ncc(F)cc23)cs1 CHEMBL4777515 Ki 1.0 nM
Cc1ccc(C(=O)OCc2ccc([C@@H](CN)C(=O)Nc3ccc4cnccc4c3)cc2)c(C)c1 CHEMBL4594250 Ki 1.0 nM
COc1cc(C(=O)NC(CN)Cc2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3964418 IC50 1.04 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1ccccc1 CHEMBL3770836 IC50 1.2 nM
CCN1CCC[C@H]1CNC(=O)c1cccc(CNC(=O)c2ccc3c(c2)C(C)Oc2cnccc2-3)c1 CHEMBL4747999 IC50 1.2 nM
COc1cccc([C@@H](C)NC(=O)c2ccc3c(c2)COc2cnccc2-3)c1 CHEMBL4785041 IC50 1.2 nM
COc1c(B(O)O)cccc1-c1nc2ccc3[nH]ncc3c2c2c1CCC2 CHEMBL4461288 IC50 1.22 nM
COc1c(B(O)O)cccc1-c1ccc2c(ccc3[nH]ncc32)n1 CHEMBL5287991 IC50 1.22 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)NCc1cccc(C(=O)NC2CCN(C)CC2)c1 CHEMBL3925017 IC50 1.24 nM
CN(C)C1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1969151 pKi 1.259 nM
COc1cccc(C(C)NC(=O)c2ccc(-c3ccncc3)s2)c1 CHEMBL1994724 pKi 1.259 nM
NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1973720 pKi 1.259 nM
C=S(=O)(O)c1ccc2c(c1)C(C)(C)C1=[N+]2CCC2OC3CCN4C(=C3C=C12)C(C)(C)c1cc(CC(=O)NCCCC[C@@H](NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)CCCCCNC(=O)[C@@H](CCCNC(=N)N)NC(=O)CCCCCCCNCCNS(=O)(=O)c2cccc3cnccc23)C(N)=O)ccc14 CHEMBL2023841 Kd 1.3 nM
CC1(C)Nc2cc(-c3ccncc3)sc2C(=O)N1Cc1ccccc1 CHEMBL4204752 IC50 1.5 nM
COc1cc(C(=O)NC(CCN(C)C)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3901295 IC50 1.53 nM
CCN1CCCC1CNC(=O)c1cccc(CNC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)c1 CHEMBL3957651 IC50 1.54 nM
CCn1c(-c2nonc2N)nc2cnc(Oc3cccc(NC(=O)c4ccc(OCCN5CCOCC5)cc4)c3)cc21 CHEMBL220241 IC50 1.6 nM
COc1cc(C(=O)NCc2cccc(C(=O)NCC3CC3)c2)ccc1-c1cn[nH]c1 CHEMBL3910152 IC50 1.79 nM
CCn1c(-c2nonc2N)nc2cnc(Oc3cccc(NC(C)=O)c3)cc21 CHEMBL218868 IC50 1.8 nM
CC(N)C1CCC(C(=O)Nc2ccncc2)CC1 CHEMBL1994526 pKi 1.995 nM
CCn1c(-c2nonc2N)nc2cnc(Oc3cccc(NC(=O)c4ccc(N(C)C)cc4)c3)cc21 CHEMBL220465 IC50 2.0 nM
NC[C@H](Cc1cccc(F)c1)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1 CHEMBL523586 IC50 2.0 nM
COc1cc(C2=NC(c3ccc(Cl)cc3F)C(C(=O)Nc3ccc4[nH]ncc4c3)=C(C)N2)ccn1 CHEMBL483402 IC50 2.0 nM
c1ccc2c(c1)CC(Nc1cc(Nc3ccncc3)nc(N3CCNCC3)n1)C2 CHEMBL575340 IC50 2.0 nM
CN(C)CCCNC(=O)c1ccc2c(c1)CC(c1nc3ccc(-c4cn[nH]c4)cc3s1)CO2 CHEMBL1079921 IC50 2.0 nM
COc1cccc(CNC(=O)c2cc3ccc(-c4cn[nH]c4)nc3n2C)c1 CHEMBL1922035 IC50 2.0 nM
COc1cccc([C@@H](C)NC(=O)c2c[nH]c3cc(-c4cn[nH]c4)ccc23)c1 CHEMBL1923173 IC50 2.0 nM
O=c1[nH]c([C@@H]2CNC[C@H]2c2ccccc2)nc2ccc(-c3cn[nH]c3)cc12 CHEMBL2334292 IC50 2.0 nM
COCCNS(=O)(=O)c1cccc(CC(=O)Nc2nc(-c3c[nH]c4ncccc34)cs2)c1 CHEMBL4241959 Ki 2.0 nM
CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(-c3c[nH]c4ncccc34)cs2)c1 CHEMBL4249925 Ki 2.0 nM
CCCS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(-c3c[nH]c4ncccc34)cs2)c1 CHEMBL4241305 Ki 2.0 nM
CC(C)S(=O)(=O)Nc1cccc(CC(=O)Nc2nc(-c3c[nH]c4ncccc34)cs2)c1 CHEMBL4244717 Ki 2.0 nM
CCCCS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(-c3c[nH]c4ncccc34)cs2)c1 CHEMBL4243658 Ki 2.0 nM
CN(C)C(C(=O)Nc1ccc2c(=O)[nH]ccc2c1)c1ccsc1 CHEMBL3545065 Ki 2.0 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3c[nH]nc3C)cc2OC)c1 CHEMBL4115244 IC50 2.15 nM
C[C@@H](NC(=O)c1ccc(-c2cn[nH]c2)c(O)c1)c1ccc(F)cc1 CHEMBL4113669 IC50 2.22 nM
CCNC[C@@H](NC(=O)c1ccc(-c2cn[nH]c2)c(OC)c1)c1c(F)cccc1F CHEMBL4107997 IC50 2.26 nM
CCNC(=O)c1cccc(CNC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)c1 CHEMBL3956238 IC50 2.39 nM
COc1cc(C(=O)NCc2cccc(C(=O)NC3CC3)c2)ccc1-c1cn[nH]c1 CHEMBL3947008 IC50 2.44 nM
Cc1cc(C(=O)NCc2cccc(C(=O)NC[C@H]3CCCN3)c2)ccc1-c1cn[nH]c1 CHEMBL4107343 IC50 2.46 nM
O=c1[nH]ccc2cc(O[C@H]3CCCNC3)ccc12 CHEMBL1667967 pKi 2.512 nM
COc1cccc(C(C)NC(=O)c2ccc(-c3ccncc3)cc2)c1 CHEMBL1975121 pKi 2.512 nM
CC(C)(CN)CNc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL1968930 pKi 2.512 nM
COC(=O)c1cccc(CNC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)c1 CHEMBL3928809 IC50 2.63 nM
CCn1c(-c2nonc2N)nc2cncc(OCC3CCNCC3)c21 CHEMBL521823 IC50 3.0 nM
COc1ccc(C2=NC(c3ccc(Cl)cc3F)C(C(=O)Nc3ccc4[nH]ncc4c3)=C(C)N2)cn1 CHEMBL483574 IC50 3.0 nM
COc1cccc(CN(C)C(=O)c2cn(C)c3cc(-c4cn[nH]c4)ccc23)c1 CHEMBL1922124 IC50 3.0 nM
COc1cccc(CNC(=O)c2cn(CCCO)c3cc(-c4cn[nH]c4)ccc23)c1 CHEMBL1922128 IC50 3.0 nM
O=C(Cc1cccc(O)c1)Nc1nc(-c2c[nH]c3ncccc23)cs1 CHEMBL4245089 Ki 3.0 nM
COc1cccc(CC(=O)Nc2nc(-c3c[nH]c4ncccc34)cs2)c1 CHEMBL4244623 Ki 3.0 nM
CCCNS(=O)(=O)c1cccc(CC(=O)Nc2nc(-c3c[nH]c4ncccc34)cs2)c1 CHEMBL4240605 Ki 3.0 nM
CN1CCN(CCOc2cccc(CC(=O)Nc3nc(-c4c[nH]c5ncccc45)cs3)c2)CC1 CHEMBL4245197 Ki 3.0 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3ccncc3)cc2N2CCC(CN)CC2)c1 CHEMBL4434688 IC50 3.0 nM
O=C(Cc1cccc(OCCCC2CCNCC2)c1)Nc1nc(-c2c[nH]c3nccc(F)c23)cs1 CHEMBL4778806 Ki 3.0 nM
CN1CCN(CCOc2cccc(CC(=O)Nc3nc(-c4c[nH]c5ncc(F)cc45)cs3)c2)CC1 CHEMBL4742150 Ki 3.0 nM
CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(-c3c[nH]c4ncc(F)cc34)cs2)c1 CHEMBL4752045 Ki 3.0 nM
CNC(=O)c1cccc(CNC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)c1 CHEMBL3958305 IC50 3.05 nM
COc1cc(C(=O)NC(C)c2ccccc2F)ccc1-c1cn[nH]c1 CHEMBL3965274 IC50 3.1 nM
COc1cc(C(=O)N[C@H](C)c2ccccc2F)ccc1-c1cn[nH]c1 CHEMBL4753754 IC50 3.1 nM
COc1cc(C(=O)NCc2cccc(C(=O)NC3(C)CC3)c2)ccc1-c1cn[nH]c1 CHEMBL3920062 IC50 3.16 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(OC(F)(F)F)c4)c3)cc12 CHEMBL1965836 pKi 3.162 nM
Nc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL2007574 pKi 3.162 nM
COc1cccc(CNC(=O)c2ccc(-c3ccncc3)cc2)c1 CHEMBL2006299 pKi 3.162 nM
CCNC(=O)c1cccc(CNC(=O)c2ccc3c(c2)C(C)Oc2cnccc2-3)c1 CHEMBL4758151 IC50 3.2 nM
COc1cc(C(=O)NCc2cccc(C(=O)NCC(C)(C)O)c2)ccc1-c1cn[nH]c1 CHEMBL3961024 IC50 3.24 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)NCc1ccc(F)cc1Cl CHEMBL3904054 IC50 3.26 nM
COc1ccc(F)c(C(C)NC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)c1 CHEMBL3898965 IC50 3.36 nM
COc1cc(C(=O)NCc2ccc(F)cc2Cl)ccc1-c1cn[nH]c1 CHEMBL3969934 IC50 3.37 nM
Cc1cc(C(=O)NCc2cccc(C(=O)NCC3CC3)c2)ccc1-c1cn[nH]c1 CHEMBL3977577 IC50 3.38 nM
Cc1cc(C(=O)N[C@H](CN)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4107839 IC50 3.38 nM
COc1ccc2c(c1)CC(C(=O)Nc1ccc(-c3cn[nH]c3)cc1OCCN(C)C)CO2 CHEMBL482336 IC50 3.4 nM
COc1cccc(CN(CCN(C)C)C(=O)c2nc3ccc(-c4cn[nH]c4)cc3s2)c1 CHEMBL1080279 IC50 3.5 nM
C[C@@H](N)c1ccc(C(=O)Nc2ccnc3[nH]ccc23)cc1 CHEMBL571948 IC50 3.6 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccc[nH]2)C(=O)N3)c1)Cc1ccccc1 CHEMBL1980407 pKi 3.981 nM
CNCC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1996980 pKi 3.981 nM
Cc1ccccc1-c1c(-c2ccc3[nH]nc(N)c3c2)nnn1Cc1ccccc1 CHEMBL2000029 pKi 3.981 nM
COc1cccc(C(C)NC(=O)c2cnc(-c3ccncc3)nc2)c1 CHEMBL2003514 pKi 3.981 nM
NCC(NC(=O)c1ccc(-c2ccncc2)cc1)c1ccccc1 CHEMBL1990254 pKi 3.981 nM
NCCC(C(=O)Nc1ccc2[nH]ncc2c1)c1ccc(Cl)c(Cl)c1 CHEMBL1998121 pKi 3.981 nM
CCn1c(-c2nonc2N)nc2cnc(Oc3cccc(NC(=O)c4ccccc4)c3)cc21 CHEMBL426526 IC50 4.0 nM
CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc(Cl)cc2F)N=C(c2ccnc(Cl)c2)N1 CHEMBL483401 IC50 4.0 nM
CCN(Cc1cccc(OC)c1)C(=O)Nc1ccc(-c2cn[nH]c2)cc1O[C@H]1CCN(C)C1 CHEMBL2332060 IC50 4.0 nM
COc1cccc(CN(C)C(=O)Nc2ccc(-c3cn[nH]c3)cc2)c1 CHEMBL2332097 IC50 4.0 nM
COc1cccc(Cn2cnc3sc(-c4ccnc5[nH]ccc45)cc3c2=O)c1 CHEMBL4638815 IC50 4.0 nM
CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(-c3c[nH]c4nccc(F)c34)cs2)c1 CHEMBL4757625 Ki 4.0 nM
Cc1n[nH]cc1-c1cc2nc(C(c3ccccc3)N3CCCC3)[nH]c(=O)c2s1 CHEMBL4065361 IC50 4.1 nM
COc1cccc([C@@H](C)NC(=O)c2ccc3c(c2)C(C2CC2)Oc2cnccc2-3)c1 CHEMBL4749267 IC50 4.1 nM
Cc1cc(C(=O)NCc2cccc(C(=O)NC3CC3)c2)ccc1-c1cn[nH]c1 CHEMBL3939581 IC50 4.22 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)NCc1c(F)cccc1F CHEMBL3939886 IC50 4.25 nM
COc1cc(C(=O)NCc2ccccc2Cl)ccc1-c1cn[nH]c1 CHEMBL3960736 IC50 4.27 nM
COc1cc(NC(=O)[C@H](N)Cc2ccc(Cl)c(Cl)c2)ccc1-c1cn[nH]c1 CHEMBL4764401 IC50 4.3 nM
CCn1c(-c2nonc2N)nc2cnc(OC)cc21 CHEMBL218257 IC50 4.4 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)NC(CN)Cc1ccccc1 CHEMBL3956875 IC50 4.6 nM
COc1cc(C(=O)N[C@H](CNC2CC2)c2c(F)cccc2F)ccc1-c1cn[nH]c1 CHEMBL4110459 IC50 4.62 nM
CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc(C(F)(F)F)cc2)CC(=O)N1 CHEMBL218719 IC50 5.0 nM
CCn1c(-c2nonc2N)nc2cncc(C(=O)N3CC[C@@H](N)C3)c21 CHEMBL523695 IC50 5.0 nM
CCn1c(-c2nonc2N)nc2cncc(C(=O)NCCNC)c21 CHEMBL506153 IC50 5.0 nM
COc1ccc(C2=NC(c3ccc(Cl)cc3F)C(C(=O)Nc3ccc4[nH]ncc4c3)=C(C)N2)cc1 CHEMBL520828 IC50 5.0 nM
COc1cccc(CNC(=O)c2cn(CCN(C)C)c3cc(-c4cn[nH]c4)ccc23)c1 CHEMBL1922129 IC50 5.0 nM
Cc1cncc2cccc(S(=O)(=O)N3CCCNC[C@@H]3C)c12 CHEMBL406821 IC50 5.0 nM
O=C(Cc1ccccc1)Nc1nc(-c2c[nH]c3ncccc23)cs1 CHEMBL4240883 Ki 5.0 nM
O=C(Cc1cccc(OCCCC2CCNCC2)c1)Nc1nc(-c2c[nH]c3ncccc23)cs1 CHEMBL4245242 Ki 5.0 nM
CN1CCN(CCCOc2cccc(CC(=O)Nc3nc(-c4c[nH]c5ncc(F)cc45)cs3)c2)CC1 CHEMBL4788786 Ki 5.0 nM
OCCOc1cccc(CN2CCC(Nc3cccc4cnccc34)C2)c1 CHEMBL5182402 Ki 5.0 nM
N[C@H](Cc1cccc(F)c1)NC(=O)c1ccc(-c2ccncc2)cc1 CHEMBL5283002 IC50 5.0 nM
OCCOc1cccc(CN2CC[C@@H](Nc3cccc4cnccc34)C2)c1 CHEMBL3689503 Ki 5.0 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 5.012 nM
Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1987448 pKi 5.012 nM
CN(C)CC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1982271 pKi 5.012 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3cn[nH]c3)cc2OC)c1 CHEMBL3907133 IC50 5.35 nM
COc1cc(C(=O)N[C@H](C)c2c(F)cccc2F)ccc1-c1cn[nH]c1 CHEMBL4746508 IC50 5.4 nM
COc1cc(C(=O)NC(C)c2c(F)cccc2F)ccc1-c1cn[nH]c1 CHEMBL3946084 IC50 5.5 nM
CCn1c(-c2nonc2N)nc2cncc(C(=O)N3CC[C@H](N)C3)c21 CHEMBL1956071 IC50 5.6 nM
COc1cc(C(=O)NCc2cccc(Cl)c2Cl)ccc1-c1cn[nH]c1 CHEMBL3915532 IC50 5.77 nM
COc1cc(C(=O)N[C@H](C)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3936323 IC50 5.91 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2F)c1 CHEMBL4111518 IC50 5.98 nM
COc1cc(C2=NC(c3ccc(Cl)cc3F)C(C(=O)Nc3cc4cn[nH]c4cc3F)=C(C)N2)ccn1 CHEMBL485612 IC50 6.0 nM
CC1=C(C(=O)Nc2cc3cn[nH]c3cc2F)C(c2ccc(Cl)cc2F)N=C(c2ccnc(Cl)c2)N1 CHEMBL521347 IC50 6.0 nM
c1ccc2c(c1)CC(Nc1nc(Nc3ccncc3)nc(N3CCNCC3)n1)C2 CHEMBL575741 IC50 6.0 nM
COc1cccc(CNC(=O)c2[nH]c3cc(-c4cn[nH]c4)ccc3c2CN2CCN(C)CC2)c1 CHEMBL1922140 IC50 6.0 nM
COc1cccc([C@@H](C)NC(=O)c2cc3ccc(-c4cn[nH]c4)nc3[nH]2)c1 CHEMBL1923181 IC50 6.0 nM
CN(C)CCC(NC(=O)Nc1ccc(-c2cn[nH]c2)cc1)c1ccccc1 CHEMBL2332059 IC50 6.0 nM
COc1cccc(CN(CCN(C)C)C(=O)Nc2ccc(-c3cn[nH]c3)cc2)c1 CHEMBL2332068 IC50 6.0 nM
COc1cccc(CN(CCO)C(=O)Nc2ccc(-c3cn[nH]c3)cc2)c1 CHEMBL2332065 IC50 6.0 nM
NC(C(=O)Nc1ccc2cnccc2c1)c1ccccc1 CHEMBL3770730 IC50 6.0 nM
O=C(Cc1ccc2c(c1)OCO2)Nc1nc(-c2c[nH]c3ncccc23)cs1 CHEMBL4248883 Ki 6.0 nM
CC(C)NS(=O)(=O)c1cccc(CC(=O)Nc2nc(-c3c[nH]c4ncccc34)cs2)c1 CHEMBL4249070 Ki 6.0 nM
CN1CCN(CCCOc2cccc(CC(=O)Nc3nc(-c4c[nH]c5ncccc45)cs3)c2)CC1 CHEMBL4248525 Ki 6.0 nM
Nc1nc(Nc2ccc(Oc3ccc4[nH]ncc4c3)c(F)c2)cc(N2C[C@@H]3CCCN[C@@H]3C2)n1 CHEMBL5285335 IC50 6.0 nM
NC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1983589 pKi 6.31 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(CN)Cc4ccccc4)c3)cc12 CHEMBL2000271 pKi 6.31 nM
O=C(NC(CCO)c1ccccc1)c1ccc(-c2ccncc2)cc1 CHEMBL1986143 pKi 6.31 nM
NC[C@@H](NC(=O)c1ccc(-c2ccncc2)cc1)c1ccccc1 CHEMBL5278787 pIC50 6.31 nM
COc1cc(C(=O)NC(CN)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3955270 IC50 6.39 nM
COc1cc(NC(=O)Cc2ccccc2Cl)ccc1-c1cn[nH]c1 CHEMBL4756156 IC50 6.4 nM
Cc1cc(C(=O)N[C@H](CN(C)C)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4109081 IC50 6.45 nM
COC(=O)c1cc(CNC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)ccc1F CHEMBL3928198 IC50 6.53 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)N[C@H](CCO)c1ccccc1 CHEMBL4108559 IC50 6.55 nM
COc1cc(C(=O)N[C@H](CNS(C)(=O)=O)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4107374 IC50 6.62 nM
COc1cc(C(=O)N[C@@H](C)c2cccc3ccccc23)ccc1-c1cn[nH]c1 CHEMBL3969951 IC50 6.68 nM
COc1cccc(CNC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)c1 CHEMBL3951271 IC50 6.69 nM
COc1cc(-c2cn[nH]c2)cc2c(=O)[nH]c([C@H](N)Cc3cccc(F)c3)nc12 CHEMBL2333908 IC50 7.0 nM
O=C(Cc1ccc2c(c1Cl)OCO2)Nc1nc(-c2ccncc2)cs1 CHEMBL3581126 Ki 7.0 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)N[C@H](C)c1ccc(F)cc1 CHEMBL4112558 IC50 7.0 nM
O=C(Cc1cccc(OCCCC2CCNCC2)c1)Nc1nc(-c2ccncc2)cs1 CHEMBL4251324 IC50 7.0 nM
CCNC(=O)c1cccc(CNC(=O)c2ccc3c(c2)COc2cnccc2-3)c1 CHEMBL4790421 IC50 7.0 nM
CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(-c3c[nH]c4ncc(O)cc34)cs2)c1 CHEMBL4751643 Ki 7.0 nM
CS(=O)(=O)Nc1cccc(CC(=O)Nc2cc(-c3c[nH]c4ncccc34)ncn2)c1 CHEMBL4781437 Ki 7.0 nM
CS(=O)(=O)Nc1cccc(CC(=O)Nc2nnc(-c3c[nH]c4ncccc34)s2)c1 CHEMBL4800244 Ki 7.0 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3cn[nH]c3)c(C(F)(F)F)c2)c1 CHEMBL4114533 IC50 7.09 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3cn[nH]c3)cc2OCCO)c1 CHEMBL4114112 IC50 7.19 nM
COc1cc(NC(=O)[C@H](N)CCc2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4741358 IC50 7.2 nM
COc1cc(C(=O)NC(CO)c2ccccc2F)ccc1-c1cn[nH]c1 CHEMBL3947211 IC50 7.22 nM
COc1cc(C(=O)NCc2ccccc2C)ccc1-c1cn[nH]c1 CHEMBL3952342 IC50 7.36 nM
COc1cc(C(=O)NC(C)c2cccc(O)n2)ccc1-c1cn[nH]c1 CHEMBL3965517 IC50 7.39 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)N[C@@H](c1ccccc1)[C@H](O)CO CHEMBL4107177 IC50 7.59 nM
COc1cc(C(=O)NCc2cccc(C(=O)O)c2)ccc1-c1cn[nH]c1 CHEMBL3921882 IC50 7.7 nM
COc1cc(C(=O)NCc2cc(Cl)ccc2Cl)ccc1-c1cn[nH]c1 CHEMBL3922088 IC50 7.72 nM
COc1cc(C(=O)NC(CCO)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3957255 IC50 7.8 nM
COc1cc(C(=O)NCc2ccccc2F)ccc1-c1cn[nH]c1 CHEMBL3966859 IC50 7.9 nM
COc1cc(C(=O)N[C@H](CO)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3955445 IC50 7.9 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 7.943 nM
Cc1n[nH]c2cnc(-c3cncc(OCC(N)Cc4cccc(C(F)(F)F)c4)c3)cc12 CHEMBL1998159 pKi 7.943 nM
COc1cccc(C(C)NC(=O)N2CC=C(c3c[nH]c4ncccc34)CC2)c1 CHEMBL1965845 pKi 7.943 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL1970903 pKi 7.943 nM
COc1cccc(C(CN)NC(=O)c2ccc(-c3ccncc3)cc2)c1 CHEMBL1976240 pKi 7.943 nM
CC1=C(C(=O)Nc2cc(Cl)c3[nH]ncc3c2)C(c2ccc(C(F)(F)F)cc2)CC(=O)N1 CHEMBL427058 IC50 8.0 nM
CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc(Cl)c(Cl)c2)CC(=O)N1 CHEMBL374453 IC50 8.0 nM
CCn1c(-c2nonc2N)nc2cncc(OC3CCNCC3)c21 CHEMBL493911 IC50 8.0 nM
CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc(F)cc2)N=C(c2ccncc2)N1 CHEMBL483395 IC50 8.0 nM
c1ccc2c(c1)CC(Oc1nc(Nc3ccncc3)nc(N3CCNCC3)n1)C2 CHEMBL584291 IC50 8.0 nM
C[C@@H]1CN(c2nc(Nc3ccncc3)nc(NC3Cc4ccccc4C3)n2)CCN1 CHEMBL575940 IC50 8.0 nM
COc1cccc(CNC(=O)c2[nH]c3cc(-c4cn[nH]c4)ccc3c2CN2CCCNCC2)c1 CHEMBL1922141 IC50 8.0 nM
COc1cc(-c2cn[nH]c2)cc2c(=O)[nH]c(C(N)c3cccc(Cl)c3)nc12 CHEMBL2333896 IC50 8.0 nM
N[C@H](Cc1ccc(F)cc1)c1nc2ccc(-c3cn[nH]c3)cc2c(=O)[nH]1 CHEMBL2333906 IC50 8.0 nM
O=C(NCc1cccc(O)c1)Nc1nc(-c2ccncc2)cs1 CHEMBL3218011 IC50 8.0 nM
O=C(Cc1cccc(OCCCN2CCNCC2)c1)Nc1nc(-c2ccncc2)cs1 CHEMBL4245507 IC50 8.0 nM
O=C(Cc1cccc(OCCN2CCNCC2)c1)Nc1nc(-c2c[nH]c3ncccc23)cs1 CHEMBL4238696 Ki 8.0 nM
CNC(=O)c1cccc(CNC(=O)c2ccc3c(c2)COc2cnccc2-3)c1 CHEMBL4746567 IC50 8.0 nM
CS(=O)(=O)Nc1cccc(CC(=O)Nc2ccc(-c3c[nH]c4ncccc34)s2)c1 CHEMBL4754058 Ki 8.0 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3cn[nH]c3)c(C)c2)c1 CHEMBL4111655 IC50 8.06 nM
COc1cc(C(=O)NCc2cccc(F)c2)ccc1-c1cn[nH]c1 CHEMBL3967386 IC50 8.42 nM
COc1cc(C(=O)NCc2c(F)ccc(F)c2Cl)ccc1-c1cn[nH]c1 CHEMBL3948586 IC50 8.46 nM
COc1cc(C(=O)N[C@@H](c2ccccc2)[C@H](O)CO)ccc1-c1cn[nH]c1 CHEMBL4107687 IC50 8.55 nM
CN1CC(NC(=O)c2cccc(CNC(=O)c3ccc4c(c3)COc3cnccc3-4)c2)C1 CHEMBL4749353 IC50 8.9 nM
NC[C@@H](NC(=O)c1ccc(-c2cn[nH]c2)c(OCCO)c1)c1ccccc1 CHEMBL4111527 IC50 8.92 nM
CC1=C(C(=O)Nc2ccc3[nH]nc(C)c3c2)C(c2ccc(C(F)(F)F)cc2)CC(=O)N1 CHEMBL218720 IC50 9.0 nM
CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc3ccccc3c2)CC(=O)N1 CHEMBL441702 IC50 9.0 nM
COc1cccc(CN(CCN(C)C)C(=O)c2cn(C)c3cc(-c4cn[nH]c4)ccc23)c1 CHEMBL1922127 IC50 9.0 nM
COc1cc(C(=O)N[C@H](C)c2ccc(F)cc2)ccc1-c1cn[nH]c1 CHEMBL3901566 IC50 9.03 nM
COc1cc(C(=O)NCc2ccccc2O)ccc1-c1cn[nH]c1 CHEMBL3986384 IC50 9.2 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)N[C@H](CO)Cc1ccccc1 CHEMBL3959761 IC50 9.8 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3cn[nH]c3)c(Cl)c2)c1 CHEMBL4109840 IC50 9.86 nM
COc1cc(C(=O)NCc2cc(F)ccc2Cl)ccc1-c1cn[nH]c1 CHEMBL3908876 IC50 9.89 nM
CC1=C(C(=O)Nc2cc3cn[nH]c3cc2F)C(c2ccc(Cl)cc2F)N=C(c2ccnc(C)c2)N1 CHEMBL485440 IC50 10.0 nM
Cc1c(-c2ccnc(N)n2)sc2ccc(C(N)c3cccc(O)c3)cc12 CHEMBL1083074 IC50 10.0 nM
COc1ccc2c(c1)C[C@H](C(=O)Nc1ccc(-c3cn[nH]c3)cc1OCC1CCN(C)CC1)NC2 CHEMBL1215304 IC50 10.0 nM
COc1cccc(CN(CCN(C)C)C(=O)Nc2ccc(-c3cn[nH]c3)cn2)c1 CHEMBL2332063 IC50 10.0 nM
O=C(Nc1ccc(-c2cn[nH]c2)cc1)NC(CCO)c1cccc(F)c1 CHEMBL2332056 IC50 10.0 nM
CS(=O)(=O)Nc1cccc(CC(=O)Nc2cc(-c3ccnc(F)c3)cs2)c1 CHEMBL3580669 Ki 10.0 nM
COc1cccc(CC(=O)Nc2cc(-c3ccncc3)cs2)c1 CHEMBL3581132 Ki 10.0 nM
COc1cc(C(=O)NCc2cccc(C(N)=O)c2)ccc1-c1cn[nH]c1 CHEMBL3985772 IC50 10.0 nM
CN1CCC(CCCOc2cccc(CC(=O)Nc3nc(-c4ccncc4)cs3)c2)CC1 CHEMBL4237479 Ki 10.0 nM
O=C(Cc1cccc(OCCCN2CCNCC2)c1)Nc1nc(-c2c[nH]c3ncccc23)cs1 CHEMBL4242191 Ki 10.0 nM
COc1nc(N[C@H]2CC[C@H](N)CC2)c(F)cc1C(N)=O CHEMBL4554795 IC50 10.0 nM
COc1cc(NC(=O)[C@H](N)Cc2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4783577 IC50 10.0 nM
CN1CCN(CCCOc2cccc(CC(=O)Nc3nc(-c4c[nH]c5nccc(F)c45)cs3)c2)CC1 CHEMBL4748596 Ki 10.0 nM
CS(=O)(=O)Nc1cccc(CC(=O)Nc2cnc(-c3c[nH]c4ncccc34)s2)c1 CHEMBL4754398 Ki 10.0 nM
COC[C@@H](NC(=O)c1ccc(-c2cn[nH]c2)c(OC)c1)c1ccccc1 CHEMBL4112614 IC50 10.3 nM
COc1cc(C(=O)NC(C)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3891623 IC50 10.5 nM
CCOc1cc(C2=NC(c3ccc(Cl)cc3F)C(C(=O)Nc3cc4cn[nH]c4cc3F)=C(C)N2)ccn1 CHEMBL521144 IC50 11.0 nM
c1ccc2c(c1)CC(Nc1nc(Nc3ccncc3)nc(N3CCCNCC3)n1)C2 CHEMBL566298 IC50 11.0 nM
COc1cccc(CNC(=O)c2c[nH]c3nc(-c4cn[nH]c4)ccc23)c1 CHEMBL1922132 IC50 11.0 nM
COc1cccc(CNC(=O)c2c[nH]c3cc(-c4ccncc4)ccc23)c1 CHEMBL1923167 IC50 11.0 nM
COc1cccc(C(CCO)NC(=O)Nc2ccc(-c3cn[nH]c3)cc2)c1 CHEMBL2332076 IC50 11.0 nM
CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc(F)c(C(=O)NCc3ccccn3)c2)NC(=O)N1 CHEMBL3808660 IC50 11.0 nM
Cc1cc(C(=O)N[C@H](C)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4111337 IC50 11.0 nM
CN(C)S(=O)(=O)c1cccc(CC(=O)Nc2nc(-c3c[nH]c4ncccc34)cs2)c1 CHEMBL4240458 Ki 11.0 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3ccncc3F)cc2)c1 CHEMBL4472858 IC50 11.0 nM
CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(-c3c[nH]c4ncc(Cl)cc34)cs2)c1 CHEMBL4793675 Ki 11.0 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)NCc1cccc(S(N)(=O)=O)c1 CHEMBL3985681 IC50 11.2 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)NCc1ccccc1Cl CHEMBL3914530 IC50 11.3 nM
COc1cc(C(=O)N[C@H](CNS(=O)(=O)C2CC2)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4107417 IC50 11.3 nM
C[C@@H](NC(=O)c1ccc(-c2cn[nH]c2)c(OC(F)F)c1)c1ccccc1 CHEMBL4108218 IC50 11.4 nM
COc1cc(C(=O)NCc2c(F)cccc2Cl)ccc1-c1cn[nH]c1 CHEMBL3960608 IC50 11.7 nM
CCNC(=O)c1cccc(CNC(=O)c2ccc(-c3cn[nH]c3)c(C)c2)c1 CHEMBL3986370 IC50 11.8 nM
COc1cccc(CNC(=O)c2cc3ccc(-c4cn[nH]c4)nc3[nH]2)c1 CHEMBL1922034 IC50 12.0 nM
CC(C)(N)CNc1nc(-c2ccncc2)nc2cnccc12 CHEMBL3338837 IC50 12.0 nM
CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc(F)c(C(=O)NCc3nccc4ccccc34)c2)NC(=O)N1 CHEMBL3809796 IC50 12.0 nM
COc1cc(C(=O)N[C@H](CO)Cc2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3896691 IC50 12.5 nM
COc1ccc(F)c(C(C)NC(=O)c2ccc(-c3cn[nH]c3)cc2OC)c1 CHEMBL3899661 IC50 12.5 nM
[2H]C([2H])([2H])Oc1cccc(C(C)NC(=O)c2sc(-c3ccncc3)nc2C)c1 CHEMBL1998110 pKi 12.59 nM
NC1CCCCC1Nc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL1994438 pKi 12.59 nM
NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(-c3ccncc3)ccc2c1=O CHEMBL340384 pKi 12.59 nM
O=c1c(NCc2ccc(Cl)cc2Cl)c(Nc2ccc3[nH]ncc3c2)c1=O CHEMBL1979554 pKi 12.59 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 12.59 nM
COc1cc(C(=O)NCc2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3910168 IC50 12.8 nM
CCn1c(-c2nonc2N)nc2cnccc21 CHEMBL189657 IC50 13.0 nM
CCn1c(-c2nonc2N)nc2cnc(Oc3cccc(C(C)=O)c3)cc21 CHEMBL387338 IC50 13.0 nM
COc1cccc(CN(CCCN(C)C)C(=O)c2cn(C)c3cc(-c4cn[nH]c4)ccc23)c1 CHEMBL1922126 IC50 13.0 nM
COc1cccc(CN(CCN2CCCC2)C(=O)Nc2ccc(-c3cn[nH]c3)cc2)c1 CHEMBL2332069 IC50 13.0 nM
COc1ccc([C@@H]2CN(C)C[C@H]2c2nc3ccc(-c4cn[nH]c4)cc3c(=O)[nH]2)cc1 CHEMBL2333887 IC50 13.0 nM
O=C(Nc1nc(-c2ccncc2)cs1)C1COc2ccccc2O1 CHEMBL510515 IC50 13.0 nM
O=c1c2cc(-c3ccnc4[nH]ccc34)sc2ncn1Cc1cccc(F)c1 CHEMBL4645138 IC50 13.0 nM
COc1ccc(Cn2cnc3sc(-c4ccnc5[nH]ccc45)cc3c2=O)cc1 CHEMBL4638636 IC50 13.0 nM
COc1cccc([C@@H](C)NC(=O)c2ccc3c(c2)OCc2cnccc2-3)c1 CHEMBL3578250 IC50 13.0 nM
Cc1cc(C(=O)N[C@H](C)c2ccc(F)cc2)ccc1-c1cn[nH]c1 CHEMBL4108570 IC50 13.1 nM
COc1cc(C(=O)NCc2c(F)ccc(C)c2F)ccc1-c1cn[nH]c1 CHEMBL3943471 IC50 13.2 nM
COc1cc(C(=O)NC2(c3ccccc3Cl)CC2)ccc1-c1cn[nH]c1 CHEMBL3923391 IC50 13.9 nM
COC(=O)c1cccc(CNC(=O)c2ccc(-c3cn[nH]c3)c(C)c2)c1 CHEMBL3934418 IC50 13.9 nM
CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc(F)cc2)NC(=O)N1 CHEMBL384073 IC50 14.0 nM
CC1=C(C(=O)Nc2cc3cn[nH]c3cc2F)C(c2ccc(C(F)(F)F)cc2)CC(=O)N1 CHEMBL375312 IC50 14.0 nM
c1ccc2c(c1)CC(Nc1cc(N3CCNCC3)nc(Nc3ccncc3)n1)C2 CHEMBL578643 IC50 14.0 nM
CNC(C(=O)Nc1cc2cc[nH]c(=O)c2cc1Cl)c1ccccc1 CHEMBL1084892 IC50 14.0 nM
COc1cccc(CN(CCN2CCCCC2)C(=O)Nc2ccc(-c3cn[nH]c3)cc2)c1 CHEMBL2332073 IC50 14.0 nM
N#Cc1cccc(CC(=O)Nc2nc(-c3c[nH]c4ncccc34)cs2)c1 CHEMBL4239032 Ki 14.0 nM
COc1cccc([C@@H](CCN2CCCC2)NC(=O)c2ccc(-c3ccncc3)cc2)c1 CHEMBL4583341 IC50 14.0 nM
CN(C)c1ccc(C(=O)Nc2cccc(NC(=O)COc3ccc4c(=O)ccoc4c3)c2)cc1 CHEMBL4438748 IC50 14.0 nM
COc1cc(NC(=O)[C@H](N)c2ccccc2Cl)ccc1-c1cn[nH]c1 CHEMBL4780269 IC50 14.0 nM
COc1cc(-c2c[nH]nc2C)ccc1C(=O)NCc1c(F)cccc1Cl CHEMBL3930850 IC50 14.2 nM
COc1ccc(F)c(CNC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)c1 CHEMBL3892122 IC50 14.3 nM
COc1cc(C(=O)NCc2c(F)ccc(OC)c2F)ccc1-c1cn[nH]c1 CHEMBL3926788 IC50 14.8 nM
CC1=C(C(=O)Nc2ccc3[nH]nc(C)c3c2)C(c2ccc(Cl)cc2F)N=C(c2ccnc(Cl)c2)N1 CHEMBL485611 IC50 15.0 nM
NC(c1cccc(Cl)c1)c1nc2ccc(-c3cn[nH]c3)cc2c(=O)[nH]1 CHEMBL2333894 IC50 15.0 nM
COc1cc(NC(=O)Cc2ccccc2Cl)ccc1-c1cnco1 CHEMBL4799221 IC50 15.0 nM
COc1cccc([C@@H](C)NC(=O)c2ccc3c(c2)OC(C)c2cnccc2-3)c1 CHEMBL4778671 IC50 15.0 nM
COc1cc(C(=O)NCc2cccc(S(N)(=O)=O)c2)ccc1-c1cn[nH]c1 CHEMBL3915928 IC50 15.2 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)N[C@@H](Cc1ccccc1)[C@H](O)CO CHEMBL3896967 IC50 15.4 nM
COc1ccc(F)c(C(C)NC(=O)c2ccc(-c3c[nH]nc3C)cc2OC)c1 CHEMBL3950642 IC50 15.6 nM
COc1cc(C(=O)NCc2ccc(Cl)cc2F)ccc1-c1cn[nH]c1 CHEMBL3938495 IC50 15.8 nM
COc1cccc(C(C)NC(=O)c2ccc(-c3ccncc3)c(F)c2)c1 CHEMBL2004934 pKi 15.85 nM
NC(Cc1c[nH]c2ccccc12)C(=O)Nc1cncc(C=Cc2ccncc2)c1 CHEMBL1983945 pKi 15.85 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCCCC2)n1 CHEMBL2006439 pKi 15.85 nM
CCN1Cc2ccccc2C[C@@H]1C(=O)Nc1cc(F)c(-c2cn[nH]c2)cc1OCCN(C)C CHEMBL1215526 IC50 16.0 nM
COc1ccc(C[C@H](N)c2nc3ccc(-c4cn[nH]c4)cc3c(=O)[nH]2)cc1 CHEMBL2333909 IC50 16.0 nM
COc1cccc(CC(=O)Nc2nc(-c3ccnc4[nH]ccc34)cs2)c1 CHEMBL4247780 Ki 16.0 nM
COc1cc(C(=O)N[C@@H](c2ccccc2F)C(C)(C)O)ccc1-c1cn[nH]c1 CHEMBL4757844 IC50 16.0 nM
N[C@@H](C(=O)Nc1ccc2c(c1)OCc1cnccc1-2)c1ccccc1 CHEMBL4748727 IC50 16.0 nM
COc1cc(C(=O)NC(c2ccccc2F)C(C)(C)O)ccc1-c1cn[nH]c1 CHEMBL3962377 IC50 16.2 nM
COc1ccc2c(c1)CC(C(=O)Nc1ccc(-c3c[nH]nc3C)cc1OCCN(C)C)CO2 CHEMBL4570327 IC50 16.3 nM
COc1cc(C(=O)NCCc2ccccc2Cl)ccc1-c1cn[nH]c1 CHEMBL3920786 IC50 16.5 nM
COc1cc(C(=O)NC(C)c2c(F)cccc2Cl)ccc1-c1cn[nH]c1 CHEMBL3926244 IC50 16.7 nM
COCCOc1cc(-c2cn[nH]c2)ccc1C(=O)N[C@H](C)c1cccc(OC)c1 CHEMBL4110456 IC50 16.8 nM
COc1cc(C(=O)NCc2ccc(Br)cc2Cl)ccc1-c1cn[nH]c1 CHEMBL3906535 IC50 16.9 nM
COc1cccc(CNC(=O)c2ccc(-c3cn[nH]c3)c(C)c2)c1 CHEMBL3967606 IC50 16.9 nM
Cc1cc(C(=O)NCc2ccc(F)cc2Cl)ccc1-c1cn[nH]c1 CHEMBL3982461 IC50 16.9 nM
N[C@@H](Cc1ccc(F)cc1)c1nc2ccc(-c3cn[nH]c3)cc2c(=O)[nH]1 CHEMBL2333905 IC50 17.0 nM
COc1cccc(C2CCCN(c3nc(-c4ccncc4)cs3)C2=O)c1 CHEMBL3581129 Ki 17.0 nM
O=c1[nH]ccc2cc(OC3CCNCC3)ccc12 CHEMBL1667969 Kd apparent 17.0 nM
CCOc1ccc(C(=O)Nc2cccc(NC(=O)COc3ccc4c(=O)ccoc4c3)c2)cc1 CHEMBL4476505 IC50 17.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 17.0 nM
O=C(N[C@H](CO)c1ccccc1)c1ccc(-c2cn[nH]c2)c(OC(F)F)c1 CHEMBL4107796 IC50 17.1 nM
C=CC(NC(=O)c1ccc(-c2cn[nH]c2)c(OC)c1)c1c(F)cccc1F CHEMBL3939661 IC50 17.5 nM
COc1cc(C(=O)NC(C)c2ccccc2Cl)ccc1-c1cn[nH]c1 CHEMBL3984075 IC50 17.7 nM
COc1cc(C(=O)NCc2c(F)cccc2F)ccc1-c1cn[nH]c1 CHEMBL3896978 IC50 17.8 nM
CCn1c(-c2nonc2N)nc2cnc(Oc3cccc(N)c3)cc21 CHEMBL373419 IC50 18.0 nM
O=C(NCCc1cccs1)c1c[nH]c2cc(-c3cn[nH]c3)ccc12 CHEMBL1923177 IC50 18.0 nM
COc1cccc(CC(=O)Nc2cc(-c3ccnc(F)c3)cs2)c1 CHEMBL3581146 Ki 18.0 nM
COc1ccc(C(=O)Nc2cccc(NC(=O)COc3ccc4c(=O)ccoc4c3)c2)cc1 CHEMBL4446390 IC50 18.0 nM
COc1cccc(Cn2cnc3sc(-c4ccnc(N)c4)cc3c2=O)c1 CHEMBL4649403 IC50 18.0 nM
C[C@@H](NC(=O)c1ccc2c(c1)OCc1cnccc1-2)c1ccccc1 CHEMBL4756660 IC50 18.0 nM
COc1cc(C(=O)NCc2cc(F)ccc2F)ccc1-c1cn[nH]c1 CHEMBL3921599 IC50 18.6 nM
CN(C)C(C(=O)Nc1cc2cc[nH]c(=O)c2cc1Cl)c1ccccc1 CHEMBL1084107 IC50 19.0 nM
COc1cccc(CNC(=O)c2cc3ccc(-c4cn[nH]c4)cc3[nH]2)c1 CHEMBL1922026 IC50 19.0 nM
COc1cccc(CN(C)C(=O)c2c[nH]c3cc(-c4cn[nH]c4)ccc23)c1 CHEMBL1922046 IC50 19.0 nM
COc1cccc(CNC(=O)c2cc3ccc(-c4cn[nH]c4C)nc3[nH]2)c1 CHEMBL1923165 IC50 19.0 nM
C[C@@H](NC(=O)Nc1nc(-c2ccncc2)cs1)c1ccccc1 CHEMBL3218277 IC50 19.0 nM
O=C(Cc1ccccc1)Nc1nc(-c2ccnc3[nH]ccc23)cs1 CHEMBL4251448 Ki 19.0 nM
CCNS(=O)(=O)c1cccc(CC(=O)Nc2nc(-c3c[nH]c4ncccc34)cs2)c1 CHEMBL4243123 Ki 19.0 nM
O=C(NCc1cccc(O)c1)c1ccc(-c2ccncc2)cc1 CHEMBL4536833 IC50 19.0 nM
N[C@H](Cc1ccccc1)C(=O)Nc1ccc2c(c1)OCc1cnccc1-2 CHEMBL4746531 IC50 19.0 nM
Cc1cncc2cccc(S(=O)(=O)N3CCNCC[C@@H]3C)c12 CHEMBL5266198 IC50 19.0 nM
Cc1cc(C(=O)NCc2c(F)cccc2Cl)ccc1-c1cn[nH]c1 CHEMBL3921203 IC50 19.7 nM
NCCNS(=O)(=O)c1ccc(-c2ccnc3[nH]ccc23)cc1 CHEMBL473080 pIC50 19.95 nM
COc1cccc(C(C)NC(=O)c2cc(C)c(-c3ccc4[nH]nc(C)c4c3)s2)c1 CHEMBL1997534 pKi 19.95 nM
c1ccc(Cn2nnc(-c3ccc4[nH]ncc4c3)c2C2CC2)cc1 CHEMBL1975418 pKi 19.95 nM
COc1cccc(C(C)NC(=O)c2ccc(-c3ccncc3C)cc2)c1 CHEMBL1970217 pKi 19.95 nM
CS(=O)(=O)NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1987948 pKi 19.95 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccccc4)c3)cc12 CHEMBL2002726 pKi 19.95 nM
OCCC(Nc1nc2ccc(-c3ccncc3)cc2s1)c1ccccc1 CHEMBL1982122 pKi 19.95 nM
NC(COc1cncc(-c2cc3ccncc3s2)c1)Cc1c[nH]c2ccccc12 CHEMBL1966524 pKi 19.95 nM
COc1cccc(C(C)NC(=O)c2ccc(-c3ccncc3F)cc2OC)c1 CHEMBL1991188 pKi 19.95 nM
CCn1c(-c2nonc2N)nc2cncc(C(=O)N3CCNCC3)c21 CHEMBL493066 IC50 20.0 nM
CCn1c(-c2nonc2N)nc2c(C#CCO)ncc(OCCCN)c21 CHEMBL523523 IC50 20.0 nM
Cc1c(-c2ccnc(N)n2)sc2ccc(Cc3cccc(O)c3)cc12 CHEMBL1082758 IC50 20.0 nM
Cc1c(-c2ccnc(N)n2)sc2ccc(Nc3cccc(O)c3)cc12 CHEMBL1083072 IC50 20.0 nM
COc1cccc(C(N)c2ccc3sc(-c4ccnc(N)n4)c(C)c3c2)c1 CHEMBL1083073 IC50 20.0 nM
Cc1c(-c2ccnc(N)n2)sc2ccc(C(N)c3ccccc3)cc12 CHEMBL1083352 IC50 20.0 nM
CCCC(N)c1ccc2sc(-c3ccnc(N)n3)c(C)c2c1 CHEMBL1083967 IC50 20.0 nM
O=C(Nc1ccc(-c2c[nH]c(=O)c3ccccc23)cc1)N1CCc2ccccc21 CHEMBL3921800 IC50 20.0 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CNCC[C@H]2c2ccc(F)c(F)c2)oc1Cl CHEMBL4457064 IC50 20.0 nM
COc1cccc(Cn2cnc3sc(-c4ccc5[nH]ncc5c4)cc3c2=O)c1 CHEMBL4636499 IC50 20.0 nM
CCNC(=O)c1cc(CNC(=O)c2ccc3c(c2)C(CC)Oc2cnccc2-3)ccc1F CHEMBL4759713 IC50 20.0 nM
Nc1nc(Nc2ccc(Oc3ccc4[nH]ncc4c3)c(F)c2)cc(-c2ccncc2)n1 CHEMBL5269267 IC50 20.0 nM
O=C(Nc1ccc(-c2n[nH]c(=O)c3ccccc23)cc1)N1CCc2ccccc21 CHEMBL5289256 IC50 20.0 nM
COc1cc(C(=O)NCc2ccccc2C(F)(F)F)ccc1-c1cn[nH]c1 CHEMBL3987039 IC50 20.4 nM
COc1cccc(CNC(=O)c2cn(-c3ccccc3)c3cc(-c4cn[nH]c4)ccc23)c1 CHEMBL1922125 IC50 21.0 nM
CC(C)(N)CNc1nc(-c2ccncc2)cc2cnccc12 CHEMBL2147538 IC50 21.0 nM
CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc(F)c(C(=O)NCc3cccc(F)c3)c2)NC(=O)N1 CHEMBL3809100 IC50 21.0 nM
COc1cc(NC(=O)[C@H](O)c2ccccc2Cl)ccc1-c1cn[nH]c1 CHEMBL4784425 IC50 21.0 nM
CCOc1cc(-c2cn[nH]c2)ccc1C(=O)N[C@H](C)c1cccc(OC)c1 CHEMBL4111653 IC50 21.1 nM
C[C@H](O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)ccc1-c1cn[nH]c1 CHEMBL4107581 IC50 21.2 nM
COc1cccc(CNC(=O)c2ccc(-c3cn[nH]c3)cc2OC)c1 CHEMBL3944065 IC50 21.3 nM
COc1cc(C(=O)NCCc2cccc(O)c2)ccc1-c1cn[nH]c1 CHEMBL3976118 IC50 21.5 nM
COc1cc(C(=O)NCc2cccc(OC(F)F)c2)ccc1-c1cn[nH]c1 CHEMBL3943648 IC50 21.8 nM
COc1cc(C(=O)NCc2c(F)cc(F)cc2F)ccc1-c1cn[nH]c1 CHEMBL3985933 IC50 21.9 nM
NCc1ccc(C(=O)NC(c2ccc(Cl)cc2)c2nc3ccc(-c4cn[nH]c4)cc3c(=O)[nH]2)cc1 CHEMBL2333884 IC50 22.0 nM
COc1cccc(CC(=O)Nc2cc(-c3ccnc(N)c3)cs2)c1 CHEMBL3581149 Ki 22.0 nM
CN1c2c(sc(-c3cn[nH]c3)c2Br)C(=O)NC1(C)C CHEMBL4205039 IC50 22.0 nM
Cc1n[nH]cc1-c1cc2c(s1)C(=O)NC(C)(CC(F)(F)F)N2C CHEMBL4214023 IC50 22.0 nM
CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(-c3c[nH]c4ncc(Br)cc34)cs2)c1 CHEMBL4746642 Ki 22.0 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3c[nH]nc3C)cc2OCCN(C)C)c1 CHEMBL4114333 IC50 22.3 nM
C[C@@H](NC(=O)c1ccc(-c2cn[nH]c2)c(OC(F)F)c1)c1ccc(F)cc1 CHEMBL4114240 IC50 22.5 nM
COc1cc(C(=O)NCc2ccc(F)c(F)c2)ccc1-c1cn[nH]c1 CHEMBL3969590 IC50 22.8 nM
COc1cc(C(=O)NCc2c(F)ccc(F)c2F)ccc1-c1cn[nH]c1 CHEMBL3965554 IC50 22.9 nM
c1ccc2c(c1)CCC(Nc1nc(Nc3ccncc3)nc(N3CCNCC3)n1)C2 CHEMBL575759 IC50 23.0 nM
COc1ccccc1CNC(=O)c1c[nH]c2cc(-c3cn[nH]c3)ccc12 CHEMBL1923169 IC50 23.0 nM
CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc(F)c(C(=O)NCCc3ccccn3)c2)NC(=O)N1 CHEMBL3810107 IC50 23.0 nM
CCOc1ccc2c(c1)N(C(=O)Cc1ccc(-c3n[nH]c(=O)c4ccccc34)cc1)CC2 CHEMBL3953195 IC50 23.0 nM
COc1cccc(CNC(=O)Nc2nc(-c3ccncc3)cs2)c1 CHEMBL3218006 IC50 23.0 nM
COc1cc(C(=O)NC(Cc2ccccc2)C(C)=O)ccc1-c1cn[nH]c1 CHEMBL3982811 IC50 23.0 nM
COc1cc(C(=O)NC[C@@H](O)c2cccc(Cl)c2)ccc1-c1cn[nH]c1 CHEMBL4109715 IC50 23.4 nM
COc1cc(C(=O)N[C@H](CNC(C)=O)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4110514 IC50 23.6 nM
COc1cc(C(=O)N[C@@H](CO)c2c(F)cccc2F)ccc1-c1cn[nH]c1 CHEMBL3920393 IC50 23.8 nM
COc1cc(C(=O)N[C@H](CO)[C@H](O)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4108938 IC50 23.9 nM
COc1cc(C(=O)N[C@H](CO)c2c(F)cccc2F)ccc1-c1cn[nH]c1 CHEMBL4799704 IC50 24.0 nM
COc1cc(C(=O)NCc2cccc(NS(C)(=O)=O)c2)ccc1-c1cn[nH]c1 CHEMBL3965403 IC50 24.6 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)NC(c1ccccc1F)C(C)(C)O CHEMBL3965594 IC50 24.7 nM
COc1cc(C(=O)NCc2ccc3sccc3c2)ccc1-c1cn[nH]c1 CHEMBL3964208 IC50 24.9 nM
COc1ccc(Cn2cnc3sc(-c4ccnc5[nH]ccc45)cc3c2=O)cc1OC CHEMBL4648698 IC50 25.0 nM
C[C@@H](N)[C@H]1CC[C@H](C(=O)Nc2ccncc2)CC1 CHEMBL559147 pKi 25.12 nM
CC(C)(CN)CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1985723 pKi 25.12 nM
COc1cccc(C(C)NC(=O)c2ccc(-c3ccncc3)c(C)c2)c1 CHEMBL1969049 pKi 25.12 nM
NC(COc1cncc(C=Cc2ccncc2)c1)Cc1c[nH]c2ccccc12 CHEMBL1974935 pKi 25.12 nM
Clc1cc(-c2c[nH]c3ncccc23)cc(NCc2ccccc2)n1 CHEMBL1969588 pKi 25.12 nM
CCCOc1cccc(C(C)NC(=O)c2ccc(-c3ccncc3)cc2)c1 CHEMBL2007296 pKi 25.12 nM
COc1cccc(CNC(=O)c2cnc(-c3ccncc3)nc2)c1 CHEMBL2004159 pKi 25.12 nM
CC1CCN(C(=O)CC#N)CC1c1ncc2cnc3[nH]ccc3n12 CHEMBL1966175 pKi 25.12 nM
COc1ccc(C2=NC(c3ccc(C(F)(F)F)cc3F)C(C(=O)Nc3ccc4[nH]ncc4c3)=C(C)N2)cc1 CHEMBL520808 IC50 26.0 nM
CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(-c3ccncc3)cs2)c1 CHEMBL3581128 Ki 26.0 nM
COc1cc(CNC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)ccc1F CHEMBL3985775 IC50 26.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 26.0 nM
COc1cc(C(=O)N[C@H](C)[C@@H](O)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3915358 IC50 26.3 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)NCc1c(F)cccc1Cl CHEMBL3978005 IC50 26.3 nM
COc1cc(C(=O)NCc2ccc(Cl)cc2)ccc1-c1cn[nH]c1 CHEMBL3965421 IC50 26.5 nM
COc1cc(C(=O)NC(C)c2cc(F)cc(F)c2)ccc1-c1cn[nH]c1 CHEMBL3934001 IC50 26.5 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)NC(C)c1c(F)cccc1F CHEMBL3894616 IC50 26.5 nM
CC(O)c1cc(C(=O)N[C@H](C)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4112045 IC50 26.8 nM
COc1cccc(CN(C)C(=O)c2cc3ccc(-c4cn[nH]c4)nc3[nH]2)c1 CHEMBL1922042 IC50 27.0 nM
NC[C@@](O)(c1ccc(Cl)cc1)c1ccc(-c2cn[nH]c2)cc1 CHEMBL3544960 Kd apparent 27.0 nM
COc1cccc(C(C)NC(=O)c2ccc3c(c2)OCc2cnccc2-3)n1 CHEMBL4749682 IC50 27.0 nM
O=C(Cc1cccc(O)c1)Nc1nc(-c2ccncc2)cs1 CHEMBL3581123 Ki 28.0 nM
COc1cc(C(=O)NCCc2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3963314 IC50 28.1 nM
CCn1c(-c2nonc2N)nc2cnc(Oc3ccccc3)cc21 CHEMBL375877 IC50 30.0 nM
Cc1c(-c2ccnc(N)n2)sc2ccc(C(N)c3cccc(Cl)c3)cc12 CHEMBL1085035 IC50 30.0 nM
Cc1c(-c2ccnc(N)n2)sc2ccc(C(N)CC(C)C)cc12 CHEMBL1082439 IC50 30.0 nM
Cc1cncc2cccc(S(=O)(=O)N3CCCNCC3C)c12 CHEMBL1082440 IC50 30.0 nM
COc1cccc(CN(C(=O)c2c[nH]c3nc(-c4cn[nH]c4)ccc23)C2CC2)c1 CHEMBL1922133 IC50 30.0 nM
COc1cccc(CNC(=O)N(C)c2nc(-c3ccncc3)cs2)c1 CHEMBL3218275 IC50 30.0 nM
O=C(Nc1nc(-c2ccncc2)cs1)N[C@H](CO)c1ccccc1 CHEMBL3218278 IC50 30.0 nM
COc1cccc([C@@H](C)NC(=O)Nc2nc(-c3ccncc3)cs2)c1 CHEMBL3218282 IC50 30.0 nM
NCCNc1nc(-c2ccncc2)cc2cnccc12 CHEMBL1214929 IC50 30.0 nM
CS(=O)(=O)Nc1cccc(CC(=O)Nc2cc(-c3ccnc(N)c3)cs2)c1 CHEMBL3581150 Ki 30.0 nM
C[C@@H](N)[C@H]1CC[C@H](C(=O)Nc2ccnc3[nH]ccc23)CC1 CHEMBL3793353 IC50 30.0 nM
CN(C)CCOc1cc(-c2ccncc2)ccc1NC(=O)C1COc2ccccc2C1 CHEMBL4521642 IC50 30.0 nM
COc1cc(C(=O)N[C@@H]2C[C@H]2c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3965294 IC50 30.1 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3c[nH]nc3C#N)cc2OC)c1 CHEMBL4113511 IC50 30.6 nM
CC1(CC(F)(F)F)NC(=O)c2sc(-c3ccncc3)cc2N1 CHEMBL4202743 IC50 31.0 nM
O=S(=O)(c1cccc2c(O)nccc12)N1CCCNCC1 CHEMBL1233300 pKi 31.62 nM
N[C@H]1CCC[C@H](Oc2ccc3c(=O)[nH]ccc3c2)C1 CHEMBL1667977 pIC50 31.62 nM
CC(=O)Nc1cccc(CNc2c(Nc3ccc4[nH]ncc4c3)c(=O)c2=O)c1 CHEMBL1988608 pKi 31.62 nM
CN(C)C1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1965702 pKi 31.62 nM
NCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1972290 pKi 31.62 nM
O=S(=O)(c1cccc2cnccc12)N1CCCNCC1 CHEMBL38380 pKi 31.62 nM
COc1cccc(C(C)NC(=O)c2sc(-c3ccncc3)nc2C)c1 CHEMBL1978567 pKi 31.62 nM
OC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1991674 pKi 31.62 nM
COc1cccc(C(C)NC(=O)c2cnc(-c3ccncc3)s2)c1 CHEMBL1984633 pKi 31.62 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 31.62 nM
CCC1CC(NS(=O)(=O)C2CC2)CC1c1ncc2cnc3[nH]ccc3n12 CHEMBL1992073 pKi 31.62 nM
CC(C)(N)CNc1nc(-c2ccc3[nH]ncc3c2)nc2cnccc12 CHEMBL3338838 IC50 32.0 nM
COc1cc(C(=O)NCc2cccc(C#N)c2)ccc1-c1cn[nH]c1 CHEMBL3914478 IC50 32.6 nM
CCn1c(-c2nonc2N)nc2cnc(Oc3cccc(S(C)(=O)=O)c3)cc21 CHEMBL220408 IC50 33.0 nM
CN(C)CCOc1cc(-c2cn[nH]c2)c(F)cc1NC(=O)[C@H]1Cc2ccccc2CN1 CHEMBL1215524 IC50 33.0 nM
COc1cccc(CN(C(=O)c2cc3ccc(-c4cn[nH]c4)nc3[nH]2)C2CC2)c1 CHEMBL1922043 IC50 33.0 nM
O=C(Nc1ccc(-c2cn[nH]c2)cc1)N(CCO)Cc1ccccc1 CHEMBL2331562 IC50 33.0 nM
C[C@H]1CNCCCN1S(=O)(=O)c1cccc2cncc(F)c12 CHEMBL3426621 Kd apparent 33.0 nM
CCCC1(C)NC(=O)c2sc(-c3ccncc3)cc2N1 CHEMBL4214928 IC50 33.0 nM
COc1cccc(CNC(=O)c2ccc3c(c2)OCc2cnccc2-3)c1 CHEMBL4797055 IC50 33.0 nM
COc1cccc(CNC(=O)c2ccc(-c3cn[nH]c3)c(F)c2)c1 CHEMBL3928973 IC50 33.3 nM
c1cc(-c2cnc(N3CCCC3)c(N3CCNCC3)n2)c2cc[nH]c2n1 CHEMBL604934 IC50 34.0 nM
COc1cccc(CNC(=O)c2[nH]c3cc(-c4cn[nH]c4)ccc3c2CN(C)C)c1 CHEMBL1922138 IC50 34.0 nM
O=C(NCc1ccc(F)c(F)c1)c1c[nH]c2cc(-c3cn[nH]c3)ccc12 CHEMBL1923172 IC50 34.0 nM
COc1cc(C(=O)NC[C@@H](C)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4109752 IC50 34.0 nM
Nc1cc(-c2cc3c(=O)n(Cc4cccc(F)c4)cnc3s2)ccn1 CHEMBL4649693 IC50 34.0 nM
COc1cc(C(=O)NCc2cc(F)c(F)c(F)c2)ccc1-c1cn[nH]c1 CHEMBL3953239 IC50 34.1 nM
C[C@H]1CN(C(=O)OCCCCO[N+](=O)[O-])CCCN1S(=O)(=O)c1cccc2cncc(F)c12 CHEMBL5200119 IC50 34.19 nM
Nc1nccc2c(S(=O)(=O)N3CCCNCC3)cccc12 CHEMBL1667963 pKi 34.67 nM
COc1cc(C(=O)NCc2ccc3c(c2)OCO3)ccc1-c1cn[nH]c1 CHEMBL3980727 IC50 34.8 nM
COc1cc(C(=O)N[C@@H](c2c(F)cccc2F)C(O)CO)ccc1-c1cn[nH]c1 CHEMBL4115278 IC50 34.9 nM
CN(C)c1ccc(C(=O)Nc2ccc(-c3n[nH]c(=O)c4ccccc34)cc2)cc1 CHEMBL3968772 IC50 35.0 nM
CC(C)C1(C)NC(=O)c2sc(-c3ccncc3)cc2N1 CHEMBL4207608 IC50 35.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 35.0 nM
COc1cc(C(=O)NCC(O)c2ccccc2Cl)ccc1-c1cn[nH]c1 CHEMBL3937215 IC50 35.5 nM
COc1cc(C(=O)NC(C)Cc2ccc(F)cc2)ccc1-c1cn[nH]c1 CHEMBL3969281 IC50 35.8 nM
c1cc2c(N3CCNCC3)nc(-c3ccc4[nH]ncc4c3)nc2cn1 CHEMBL3338839 IC50 36.0 nM
CCC1(C)NC(=O)c2sc(-c3ccncc3)cc2N1 CHEMBL4203275 IC50 36.0 nM
COc1cc(C(=O)N[C@H](C)c2ccc3ccccc3c2)ccc1-c1cn[nH]c1 CHEMBL3916608 IC50 36.3 nM
CCc1ccccc1CNC(=O)c1ccc(-c2cn[nH]c2)c(OC)c1 CHEMBL3932451 IC50 36.4 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 37.0 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccccc4)c3)cc12 CHEMBL379218 Kd 37.0 nM
COc1cccc(CN(C)C(=O)c2cc3ccc(-c4cn[nH]c4)cc3[nH]2)c1 CHEMBL1922029 IC50 37.0 nM
O=C1NC2(CCCCCC2)Nc2cc(-c3ccncc3)sc21 CHEMBL4216947 IC50 37.0 nM
COc1cc(-c2cn[nH]c2)c(F)cc1C(=O)N[C@H](C)c1ccccc1 CHEMBL4108065 IC50 37.1 nM
Nc1nccc2cc(O[C@H]3CCCNC3)ccc12 CHEMBL1643368 pKi 37.15 nM
COc1cc(C(=O)NC(CO)c2c(F)cccc2F)ccc1-c1cn[nH]c1 CHEMBL3930451 IC50 37.3 nM
COc1cc(C(=O)NCCc2ccc(F)cc2)ccc1-c1cn[nH]c1 CHEMBL3892048 IC50 37.4 nM
COc1cc(C(=O)N[C@@H](Cc2ccccc2)C(N)=O)ccc1-c1cn[nH]c1 CHEMBL3918124 IC50 37.4 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CN[C@H](CCO)C[C@H]2c2ccc(F)c(F)c2)oc1Cl CHEMBL4441825 IC50 38.0 nM
COc1cccc([C@@H](C)NC(=O)c2ccc3c(c2)COc2cncnc2-3)c1 CHEMBL4797403 IC50 38.0 nM
COc1cc(C(=O)NCc2cc(F)cc(F)c2F)ccc1-c1cn[nH]c1 CHEMBL3973474 IC50 38.5 nM
COc1cc(C(=O)NCC(C#N)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3903819 IC50 38.7 nM
O=C(Nc1cc2cc[nH]c(=O)c2cc1Cl)C(NC1CC1)c1ccccc1 CHEMBL1084106 IC50 39.0 nM
COc1cccc(CNC(=O)c2[nH]c3nc(-c4cn[nH]c4)ccc3c2CN2CCN(C)CC2)c1 CHEMBL1922142 IC50 39.0 nM
c1ccc2c(N3CCNCC3)nc(-c3ccc4[nH]ncc4c3)nc2c1 CHEMBL3338840 IC50 39.0 nM
COc1cccc([C@@H](CCO)NC(=O)c2ccc(-c3ccncc3)cc2)c1 CHEMBL4469316 IC50 39.0 nM
COc1cc(C(=O)NCc2ccc(F)c(C(=O)O)c2)ccc1-c1cn[nH]c1 CHEMBL3964232 IC50 39.2 nM
COc1cc(-c2c[nH]nc2C(F)(F)F)ccc1C(=O)NCc1c(F)cccc1Cl CHEMBL3957411 IC50 39.4 nM
Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1990583 pKi 39.81 nM
CS(=O)(=O)NCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL2005718 pKi 39.81 nM
CN(C)c1cccc2c(S(=O)(=O)N(CCN)c3cncc(-c4ccc5cnccc5c4)c3)cccc12 CHEMBL1967544 pKi 39.81 nM
COc1cccc(C(C)NC(=O)c2ccc(-c3ccncc3)cc2NCCCN)c1 CHEMBL2006188 pKi 39.81 nM
CS(=O)(=O)NC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2005216 pKi 39.81 nM
CC(NC(=O)c1ccc(-c2ccncc2)cc1)c1ccccc1 CHEMBL1999428 pKi 39.81 nM
CCn1c(-c2nonc2N)nc2cncc(C(=O)NC3CCCNC3)c21 CHEMBL493067 IC50 40.0 nM
COc1cccc(CNC(=O)c2[nH]c3cc(-c4cn[nH]c4)ccc3c2CN2CCOCC2)c1 CHEMBL1922139 IC50 40.0 nM
COc1cccc(CN(C)C(=O)Nc2nc(-c3ccncc3)cs2)c1 CHEMBL3218276 IC50 40.0 nM
Cc1n[nH]cc1-c1cc2nc(C(C)N3CCCC3)[nH]c(=O)c2s1 CHEMBL4086790 IC50 40.0 nM
CS(=O)(=O)c1cccc(CC(=O)Nc2nc(-c3c[nH]c4ncccc34)cs2)c1 CHEMBL4237255 Ki 40.0 nM
CC(C)NC(=O)COc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3ccccc3n2)c1 CHEMBL2005186 Ki 40.0 nM
COc1cc(C(=O)N[C@H](C)c2ccccc2Cl)ccc1-c1cn[nH]c1 CHEMBL3890863 IC50 40.8 nM
CNC(=O)C[C@@H](NC(=O)c1ccc(-c2cn[nH]c2)c(C)c1)c1ccccc1 CHEMBL4109757 IC50 41.1 nM
COc1cc(C(=O)NCc2cccc3[nH]ncc23)ccc1-c1cn[nH]c1 CHEMBL3936240 IC50 41.8 nM
COc1cc(C(=O)NCC(O)c2cccc(Cl)c2)ccc1-c1cn[nH]c1 CHEMBL3891207 IC50 42.03 nM
O=C(N[C@H](CO)c1c(F)cccc1F)c1ccc(-c2cn[nH]c2)c(Cl)c1 CHEMBL4107563 IC50 42.3 nM
COc1cc(C(=O)NCc2cccc(C(F)(F)F)c2)ccc1-c1cn[nH]c1 CHEMBL3952741 IC50 43.3 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3cn[nH]c3)cc2F)c1 CHEMBL4110256 IC50 43.3 nM
COc1cccc(CC(=O)Nc2cc(-c3ccnc(Cl)c3)cs2)c1 CHEMBL3581147 Ki 44.0 nM
Cc1c(-c2cn[nH]c2)sc2c1N(C)C(C)(C)NC2=O CHEMBL4204540 IC50 44.0 nM
C[C@H]1CN(C(=O)OCCCCCO[N+](=O)[O-])CCCN1S(=O)(=O)c1cccc2cncc(F)c12 CHEMBL5178069 IC50 44.59 nM
CS(=O)(=O)Nc1cccc(CC(=O)Nc2cc(-c3ccnc(Cl)c3)cs2)c1 CHEMBL3581148 Ki 45.0 nM
CN1CCN(CCCOc2cccc(CC(=O)Nc3nc(-c4ccncc4)cs3)c2)CC1 CHEMBL4241204 Ki 45.0 nM
COc1cccc(Cn2cnc3sc(-c4ccncc4)cc3c2=O)c1 CHEMBL4643315 IC50 45.0 nM
Cc1cc(C(=O)N[C@H](CC(=O)O)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4113981 IC50 45.7 nM
COc1ccc(C2=NC(c3ccc(F)cc3)C(C(=O)Nc3ccc4[nH]ncc4c3)=C(C)N2)cc1 CHEMBL519008 IC50 46.0 nM
C[C@@H](N)[C@H]1CC[C@H](C(=O)Nc2ccncc2)CC1 CHEMBL1605605 IC50 46.0 nM
COc1cccc(CN(CCCN(C)C)C(=O)c2cc3ccc(-c4cn[nH]c4)cc3[nH]2)c1 CHEMBL1922033 IC50 46.0 nM
O=C(N[C@H](CCN1CCCC1)c1ccccc1)c1ccc(-c2ccncc2)cc1 CHEMBL4459077 IC50 46.0 nM
O=C(Cc1cccc(OCCN2CCNCC2)c1)Nc1nc(-c2ccncc2)cs1 CHEMBL4240949 Ki 47.0 nM
C[C@H]1CN(C(=O)OCCO[N+](=O)[O-])CCCN1S(=O)(=O)c1cccc2cncc(F)c12 CHEMBL5192517 IC50 47.27 nM
Cc1cc2c(=O)[nH]ccc2cc1O[C@H]1CCCNC1 CHEMBL1667975 pIC50 47.86 nM
COc1ccc2c(c1)C[C@H](C(=O)Nc1ccc(-c3cn[nH]c3)cc1OCCN(C)C)NC2 CHEMBL1215171 IC50 48.0 nM
COc1cccc(CNC(=O)c2c[nH]c3nc(-c4ccncc4)ccc23)c1 CHEMBL1923168 IC50 48.0 nM
COc1ccc(C(N)c2nc3ccc(-c4cn[nH]c4)cc3c(=O)[nH]2)cc1 CHEMBL2334288 IC50 48.0 nM
Cc1n[nH]cc1-c1cc2c(s1)C(=O)NC1(CCCCC1)N2 CHEMBL4216005 IC50 48.0 nM
COc1cc(NC(=O)[C@@H](N)CCc2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4749675 IC50 48.0 nM
CS(=O)(=O)Nc1cccc(CC(=O)Nc2nccc(-c3c[nH]c4ncccc34)n2)c1 CHEMBL4752171 Ki 48.0 nM
O=C(Nc1ccc(-c2n[nH]c(=O)c3ccccc23)cc1)c1ccc(N2CCCCC2)cc1 CHEMBL3935660 IC50 49.0 nM
CN(C)c1ccc(C(=O)Nc2cc(F)cc(NC(=O)COc3ccc4c(=O)ccoc4c3)c2)cc1 CHEMBL4457201 IC50 49.0 nM
Cc1cccc(C(N)c2ccc3sc(-c4ccnc(N)n4)c(C)c3c2)c1 CHEMBL1083351 IC50 50.0 nM
Nc1cccc(CNC(=O)Nc2nc(-c3ccncc3)cs2)c1 CHEMBL3218009 IC50 50.0 nM
COc1ccc(CNC(=O)c2cc(C3NC(=O)NC(C)=C3C(=O)Nc3ccc4[nH]ncc4c3)ccc2F)cc1 CHEMBL3810073 IC50 50.0 nM
COc1cc(C(=O)N[C@H](C)c2ccc3c(c2)CCO3)ccc1-c1cn[nH]c1 CHEMBL4110015 IC50 50.1 nM
Cc1cc(O)ccc1-n1cc(C(=O)NN)c(=O)c2ccc(-c3ccncc3)cc21 CHEMBL2000894 pKi 50.12 nM
O=C(NC(CO)c1ccccc1)c1ccc(-c2ccncc2)cc1 CHEMBL1974288 pKi 50.12 nM
CNCC#Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL1964441 pKi 50.12 nM
Cc1n[nH]c2ccc(-c3cncc(OCCN)c3)cc12 CHEMBL1967887 pKi 50.12 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 50.12 nM
c1ccc2c(c1)nnn2Cc1cn(-c2ccc3[nH]ncc3c2)nn1 CHEMBL1966069 pKi 50.12 nM
COc1cc(C(=O)NC[C@H](C)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3912670 IC50 50.5 nM
CC(O)c1cc(C(=O)N[C@H](C)c2ccccc2F)ccc1-c1cn[nH]c1 CHEMBL4113260 IC50 50.6 nM
CCOc1cc(C(=O)N[C@H](CO)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4108225 IC50 50.8 nM
CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc(F)cc2)CC(=O)N1 CHEMBL218654 IC50 51.0 nM
Cc1c[nH]c2ncnc(N3CCN(C(=O)Nc4ccc(F)c(Br)c4)[C@@H](C)C3)c12 CHEMBL570820 IC50 51.0 nM
COc1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CO)ccc1-c1cn[nH]c1 CHEMBL3928475 IC50 51.5 nM
NCCNc1nc(-c2ccc3[nH]ncc3c2)nc2ccccc12 CHEMBL3338842 IC50 52.0 nM
Cc1sc(NC(=O)Cc2cccc(NS(C)(=O)=O)c2)nc1-c1c[nH]c2ncccc12 CHEMBL4763436 Ki 52.0 nM
Cc1cc(C(=O)N[C@H](CO)c2c(F)cccc2F)ccc1-c1cn[nH]c1 CHEMBL4110689 IC50 52.6 nM
CC(O)c1cc(C(=O)NC(C)c2ccccc2F)ccc1-c1cn[nH]c1 CHEMBL3890248 IC50 52.9 nM
O=C(CNCc1ccccc1)Nc1cc2cc[nH]c(=O)c2cc1Cl CHEMBL1084900 IC50 53.0 nM
O=C1NC2(CCCCC2)Nc2cc(-c3ccncc3)sc21 CHEMBL4207094 IC50 53.0 nM
C[C@H]1CN(C(=O)O[C@@H]2CO[C@H]3[C@@H]2OC[C@@H]3O[N+](=O)[O-])CCCN1S(=O)(=O)c1cccc2cncc(F)c12 CHEMBL5206981 IC50 53.56 nM
COC(=O)C[C@H](NC(=O)c1ccc(-c2cn[nH]c2)c(OC)c1)c1ccccc1 CHEMBL3902479 IC50 53.7 nM
COc1cc(C(=O)NC[C@H](O)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3898415 IC50 53.7 nM
Cc1n[nH]cc1-c1cc2c(s1)C(=O)NC(C)(C)N2C CHEMBL4209096 IC50 54.0 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(B(O)O)cc1 CHEMBL5407819 IC50 54.0 nM
COc1cccc(C2(NC(=O)c3ccc(-c4cn[nH]c4)c(OC)c3)CC2)c1 CHEMBL3978630 IC50 55.2 nM
CCS(=O)(=O)NC[C@@H](NC(=O)c1ccc(-c2cn[nH]c2)c(OC)c1)c1ccccc1 CHEMBL4113161 IC50 55.2 nM
COc1cccc(C(C)NC(=O)c2ccc(-c3cn[nH]c3)c(C#N)c2)c1 CHEMBL3937334 IC50 55.6 nM
CN(C)CCOc1cc(-c2cn[nH]c2)ccc1NC(=O)C1COc2ccccc2O1 CHEMBL521179 IC50 56.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 56.0 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3cn[nH]c3)c(C#N)c2)c1 CHEMBL4740106 IC50 56.0 nM
COc1cccc([C@@H](C)NC(=O)c2ccc3c(c2)[nH]c(=O)c2cnccc23)c1 CHEMBL4782709 IC50 56.0 nM
COc1ccccc1CNC(=O)c1cc(C2NC(=O)NC(C)=C2C(=O)Nc2ccc3[nH]ncc3c2)ccc1F CHEMBL3809965 IC50 57.0 nM
O=c1[nH]ccc2cc(O[C@H]3CCCNCC3)ccc12 CHEMBL1667970 pIC50 57.54 nM
COc1cccc(CN(CCN2CCOCC2)C(=O)Nc2ccc(-c3cn[nH]c3)cc2)c1 CHEMBL2332071 IC50 58.0 nM
C[C@H]1CN(C(=O)OCCCCO[N+](=O)[O-])CCCN1S(=O)(=O)c1cccc2cncc(F)c12 CHEMBL5209106 IC50 58.32 nM
NC(C(=O)Nc1cc2cc[nH]c(=O)c2cc1Cl)c1ccccc1 CHEMBL1085141 IC50 59.0 nM
CC(C)c1c(Oc2ccc(CN)cc2Cl)ccc2c1B(O)OC2 CHEMBL5273774 IC50 59.0 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)NC(C)c1c(F)cccc1Cl CHEMBL3908187 IC50 59.6 nM
C[C@@H](Nc1c(Nc2ccncc2)c(=O)c1=O)c1ccccc1 CHEMBL466496 IC50 60.0 nM
NC(=O)C(Nc1c(Nc2ccncc2)c(=O)c1=O)c1cccc(O)c1 CHEMBL511410 IC50 60.0 nM
Cc1c(-c2ccnc(N)n2)sc2ccc(Cc3cccc(C(=O)O)c3)cc12 CHEMBL1084791 IC50 60.0 nM
Cc1c(-c2ccnc(N)n2)sc2ccc(C(N)C(C)C)cc12 CHEMBL1085935 IC50 60.0 nM
N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL1789941 Kd 60.0 nM
O=C(Nc1nc(-c2ccncc2)cs1)NC(CO)c1ccccc1 CHEMBL3218295 IC50 60.0 nM
COc1cccc(CC(=O)Nc2csc(-c3ccncc3)c2)c1 CHEMBL3581133 Ki 61.0 nM
Cc1cc(C(=O)NCc2cccc(C(=O)O)c2)ccc1-c1cn[nH]c1 CHEMBL3985261 IC50 61.4 nM
COc1cccc(CN(CCN2CCCC2)C(=O)c2cc3ccc(-c4cn[nH]c4)cc3[nH]2)c1 CHEMBL1922032 IC50 62.0 nM
Nc1nccc2cc(CNCCc3ccccc3)ccc12 CHEMBL1643361 pKi 63.1 nM
O=C(NCCc1cccs1)N1CC=C(c2c[nH]c3ncccc23)CC1 CHEMBL1987535 pKi 63.1 nM
Cc1cccc(Nc2nc(NC3CCCCC3N)cnc2C(N)=O)c1 CHEMBL1974328 pKi 63.1 nM
c1ccc(Cc2cn(-c3ccc4[nH]ncc4c3)nn2)cc1 CHEMBL1682341 pKi 63.1 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(Cl)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1987054 pKi 63.1 nM
O=C(N[C@H](CO)c1c(F)cccc1F)c1ccc(-c2cn[nH]c2)c(OC(F)F)c1 CHEMBL4114203 IC50 63.7 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3c[nH]nc3CO)cc2OC)c1 CHEMBL4110004 IC50 63.8 nM
COc1cc(C(=O)NCc2ccc(F)c(OC)c2F)ccc1-c1cn[nH]c1 CHEMBL3951004 IC50 64.0 nM
CNC(=O)C[C@@H]1C[C@@H](c2ccc(F)c(F)c2)[C@H](NC(=O)c2cc(-c3c(Cl)cnn3C)c(Cl)o2)CN1 CHEMBL4440965 IC50 64.0 nM
C[C@H]1CNCCCN1S(=O)(=O)c1cccc2cncc(F)c12 CHEMBL4594454 IC50 64.0 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)N[C@H](CO)[C@H](O)c1ccccc1 CHEMBL4106810 IC50 64.2 nM
COc1cc(C(=O)NCc2cccc(C(=O)N3CCCC3)c2)ccc1-c1cn[nH]c1 CHEMBL3935094 IC50 64.3 nM
O=C(COc1ccc2c(=O)ccoc2c1)Nc1cccc(NC(=O)c2ccc([N+](=O)[O-])cc2)c1 CHEMBL4467403 IC50 67.0 nM
COc1ccc(C2=NC(c3ccc(S(N)(=O)=O)cc3)C(C(=O)Nc3ccc4[nH]ncc4c3)=C(C)N2)cc1 CHEMBL483575 IC50 68.0 nM
Cc1cc(C(=O)Nc2cccc(NC(=O)COc3ccc4c(=O)ccoc4c3)c2)no1 CHEMBL4562184 IC50 68.0 nM
COc1ccc2c(c1)C[C@H](C(=O)Nc1ccc(-c3ccncc3)cc1OCCN(C)C)CO2 CHEMBL4552537 IC50 68.0 nM
Cc1c[nH]c2ncnc(N3CCC(CN)(C(=O)Nc4cccc(OC(=O)N(C)C)c4)CC3)c12 CHEMBL3356433 IC50 69.0 nM
CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc(F)c(C(=O)NCc3ccccc3)c2)NC(=O)N1 CHEMBL3808840 IC50 69.0 nM
COC[C@@H](NC(=O)Nc1nc(-c2ccncc2)cs1)c1ccccc1 CHEMBL3218281 IC50 70.0 nM
O=C(Cc1ccc(O)cc1)Nc1nc(-c2ccncc2)cs1 CHEMBL3581124 Ki 70.0 nM
COC(=O)c1n[nH]cc1-c1ccc(C(=O)N[C@H](C)c2cccc(OC)c2)c(OC)c1 CHEMBL4109268 IC50 70.9 nM
N[C@@H](COc1ccc2c(c1)OCc1cnccc1-2)Cc1ccccc1 CHEMBL4743809 IC50 71.0 nM
Cc1cc(=O)n(-c2cccc(CN[C@H]3CCC[C@H](Nc4ccc5[nH]ncc5c4)C3)c2)cc1F CHEMBL5407146 IC50 71.2 nM
COC(=O)c1ccc(C(=O)Nc2cccc(NC(=O)COc3ccc4c(=O)ccoc4c3)c2)cc1 CHEMBL4533805 IC50 72.0 nM
COc1cc(C(=O)N[C@@H](C)c2ccccc2OC)ccc1-c1cn[nH]c1 CHEMBL3893355 IC50 72.4 nM
c1ccc(CN2CCC[C@@H](Oc3ccc4cnccc4c3)C2)cc1 CHEMBL1667966 pIC50 72.44 nM
COc1cccc(C(C)NC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)n1 CHEMBL3905628 IC50 73.4 nM
COc1cc(Cn2cnc3sc(-c4ccnc5[nH]ccc45)cc3c2=O)cc(OC)c1 CHEMBL4634539 IC50 74.0 nM
CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc(F)cc2)N=C(c2ccc(C(F)(F)F)nc2)N1 CHEMBL485598 IC50 75.0 nM
CCN(Cc1cccc(OC)c1)C(=O)c1c[nH]c2nc(-c3cn[nH]c3)ccc12 CHEMBL1922134 IC50 76.0 nM
COc1cccc(CNC(=O)c2nc3cc(-c4cc[nH]n4)ccc3s2)c1 CHEMBL1923183 IC50 76.0 nM
CC[C@@H](NC(=O)c1ccc(-c2cn[nH]c2)c(OC)c1)c1c(F)cccc1F CHEMBL4115593 IC50 77.3 nM
COc1cc(C(=O)N[C@@H](CO)Cc2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4112104 IC50 77.9 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL1972158 pKi 79.43 nM
O=c1c(NCc2ccc(Cl)c(Cl)c2)c(Nc2ccncc2)c1=O CHEMBL1975900 pKi 79.43 nM
O=C1NCc2c1cccc2-c1ccc(Nc2nc3ccccc3o2)cc1 CHEMBL2004771 pKi 79.43 nM
O=C(Nc1ccc(-c2ccc3cn[nH]c3c2)cc1)Nc1cccc(F)c1 CHEMBL1969942 pKi 79.43 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 79.43 nM
O=C(Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1)c1c(F)cccc1F CHEMBL1991410 pKi 79.43 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4[nH]ncc34)cc2)c1 CHEMBL375284 pKi 79.43 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccc(F)cc3)cc12 CHEMBL1986499 pKi 79.43 nM
Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCC#N)c4c21)CNC3=O CHEMBL302449 pKi 79.43 nM
NCCCNS(=O)(=O)c1cccc(C(=O)Nc2ccc(-c3n[nH]c(=O)c4ccccc34)cc2)c1 CHEMBL1966279 pKi 79.43 nM
c1ccc(CNc2nc3ccc(-c4ccncc4)cc3s2)cc1 CHEMBL1983534 pKi 79.43 nM
NC(=O)[C@@H](NC(=O)Nc1nc(-c2ccncc2)cs1)c1ccccc1 CHEMBL3218280 IC50 80.0 nM
CNCCN(C)c1nc(Nc2ccncc2)nc(NC2Cc3ccccc3C2)n1 CHEMBL577177 IC50 81.0 nM
O=C(Cc1ccc(F)cc1)Nc1nc(-c2ccncc2)cs1 CHEMBL3581119 Ki 81.0 nM
O=C(NCc1ccccc1)c1ccc2c(c1)OCc1cnccc1-2 CHEMBL4748957 IC50 81.0 nM
NC[C@@H]1CC[C@H](Oc2ccc3c(=O)[nH]ccc3c2)C1 CHEMBL1667979 pIC50 81.28 nM
COc1ccc(F)c(C(C)NC(=O)c2ccc(-c3cn[nH]c3)c(C(C)O)c2)c1 CHEMBL3950612 IC50 82.2 nM
CCOc1cc(C(=O)N[C@H](CO)c2c(F)cccc2F)ccc1-c1cn[nH]c1 CHEMBL4106845 IC50 82.7 nM
COc1cccc(CC(=O)Nc2nc(-c3ccncc3)cs2)c1 CHEMBL3581121 Ki 83.0 nM
CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc(F)c(C(=O)NCCc3ccncc3)c2)NC(=O)N1 CHEMBL3808565 IC50 84.0 nM
COc1cc(C(=O)NC[C@@H](O)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4113575 IC50 84.1 nM
Nc1ccc2c(c1)nc(-c1nonc1N)n2C1CCC1 CHEMBL1080071 Ki 85.0 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3ccnc(F)c3)cc2)c1 CHEMBL4459800 IC50 85.0 nM
O=C(Nc1ccc(-c2ccncc2)cc1)N[C@@H](CO)c1ccccc1 CHEMBL2023157 IC50 85.0 nM
CC(C)(O)COc1cc(C(=O)N[C@H](CN)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4107181 IC50 85.1 nM
COc1cc(C(=O)NCc2ccccc2OC(F)(F)F)ccc1-c1cn[nH]c1 CHEMBL3981137 IC50 85.8 nM
C[C@H]1CNCCN1c1nc(Nc2ccncc2)nc(NC2Cc3ccccc3C2)n1 CHEMBL575575 IC50 87.0 nM
COc1cccc(CNC(=O)c2cc3ccc(-c4cn[nH]c4)cc3n2CCCO)c1 CHEMBL1922027 IC50 88.0 nM
COc1cccc(CNC(=O)c2cc3ccc(-c4cn[nH]c4)nc3n2CCCO)c1 CHEMBL1922039 IC50 88.0 nM
CN1CCN(CCOc2cccc(CC(=O)Nc3nc(-c4ccncc4)cs3)c2)CC1 CHEMBL4241689 Ki 88.0 nM
COc1cccc(CNC(=O)c2cn(CCN3CCCC3)c3nc(-c4cn[nH]c4)ccc23)c1 CHEMBL1922137 IC50 89.0 nM
COc1cccc(CC(=O)Nc2nc(-c3ccncc3)ns2)c1 CHEMBL3581135 Ki 89.0 nM
CCn1c(-c2nonc2N)nc2cnc(Oc3ccc(NC(C)=O)cc3)cc21 CHEMBL218869 IC50 90.0 nM
COc1ccc(C(N)c2ccc3sc(-c4ccnc(N)n4)c(C)c3c2)cc1 CHEMBL1084795 IC50 90.0 nM
CC[C@@H](NC(=O)Nc1nc(-c2ccncc2)cs1)c1ccccc1 CHEMBL3218279 IC50 90.0 nM
CC1(C)NC(=O)c2sc(-c3ccncc3)cc2N1 CHEMBL4215449 IC50 90.0 nM
COc1cccc(CNC(=O)c2[nH]c3nc(-c4cn[nH]c4)ccc3c2CN2CCOCC2)c1 CHEMBL1922143 IC50 91.0 nM
CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(-c3c[nH]c4nccc(Cl)c34)cs2)c1 CHEMBL4778609 Ki 92.0 nM
COc1cccc(CCNC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)c1 CHEMBL3965912 IC50 92.9 nM
COc1cccc(CN2CCOc3cc(-c4ccncc4)ccc3C2=O)c1 CHEMBL4877688 IC50 93.0 nM
COc1cc(C(=O)NCCc2cccc(C(F)(F)F)c2)ccc1-c1cn[nH]c1 CHEMBL3928122 IC50 94.6 nM
COc1ccc(-c2cc3c(N[C@@H]4CC[C@](C)(N)C4(C)C)c(C(N)=O)cnn3c2)cn1 CHEMBL4080797 IC50 95.0 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3ccncc3)cc2NCCCN)c1 CHEMBL4553926 IC50 95.0 nM
Cc1n[nH]cc1-c1cc2nc(C34CCC(CC3)N4)[nH]c(=O)c2s1 CHEMBL4462898 IC50 96.0 nM
COc1cc(C(=O)N[C@@H](C)c2ccccc2Cl)ccc1-c1cn[nH]c1 CHEMBL3934496 IC50 96.1 nM
O=c1cc(-c2ccccc2)ccn1-c1cccc(CN[C@H]2CCC[C@H](Nc3ccc4[nH]ncc4c3)C2)c1 CHEMBL5420736 IC50 96.1 nM
COc1cccc(CNC(=O)c2cc(C3NC(=O)NC(C)=C3C(=O)Nc3ccc4[nH]ncc4c3)ccc2F)c1 CHEMBL3810312 IC50 97.0 nM
CC(=O)NC[C@@H](NC(=O)c1ccc(-c2cn[nH]c2)c(C)c1)c1ccccc1 CHEMBL4109115 IC50 97.2 nM
CCC(O)c1cc(C(=O)N[C@H](C)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4108515 IC50 97.6 nM
C[C@@H](NC(=O)Nc1cc2[nH]ncc2c(CO)n1)c1ccccc1 CHEMBL4538174 Kd 98.0 nM
CC(O)c1cc(C(=O)N[C@H](C)c2c(F)cccc2F)ccc1-c1cn[nH]c1 CHEMBL4114494 IC50 98.2 nM
Cc1cc(C(=O)N[C@H](CC(=O)NCC(C)(C)O)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4111334 IC50 99.0 nM
COc1cc(C(=O)NCc2ccc(Cl)cc2Cl)ccc1-c1cn[nH]c1 CHEMBL3914458 IC50 99.3 nM
O=c1cc(-c2ccccc2)ccn1-c1cccc(CN[C@H]2CCC[C@@H](Nc3ccc4[nH]ncc4c3)C2)c1 CHEMBL5403316 IC50 99.4 nM