CCCC(=O)Nc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3cc(OCCN4CCC(O)C4)ccc3n2)c1 CHEMBL3666724 IC50 8e-06 nM
CCCC(=O)Nc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3cc(OCCN4CC[C@H](N(C)C)C4)c(OC)cc3n2)c1 CHEMBL3666728 IC50 1e-05 nM
CCCC(=O)Nc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3cc(OCCN4CCCC4)ccc3n2)c1 CHEMBL1968705 IC50 1e-05 nM
CCCC(=O)Nc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3cc(OCCOC)ccc3n2)c1 CHEMBL1997433 IC50 1.1e-05 nM
CCCC(=O)Nc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3cc(OCCN4CCCCC4)ccc3n2)c1 CHEMBL3666721 IC50 1.2e-05 nM
CCCC(=O)Nc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3cc(OCCN4CCN(C)CC4)ccc3n2)c1 CHEMBL3666722 IC50 1.2e-05 nM
CCCC(=O)Nc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3cc(OCCN4CCN(C)CC4)c(OC)cc3n2)c1 CHEMBL3666727 IC50 1.4e-05 nM
CCCC(=O)Nc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3cc(OC)c(OCCOC)cc3n2)c1 CHEMBL3666758 IC50 2.4e-05 nM
CCCCC(=O)Nc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3ccccc3n2)c1 CHEMBL3666756 IC50 2.9e-05 nM
CCCC(=O)Nc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3cc(OCCOC)c(OC)cc3n2)c1 CHEMBL3666726 IC50 2.9e-05 nM
CCCC(=O)Nc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3cc(OCCN4CCCC4=O)c(OC)cc3n2)c1 CHEMBL3666725 IC50 4.8e-05 nM
CCCC(=O)Nc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3cc(OCCN4CCCC4=O)ccc3n2)c1 CHEMBL3666723 IC50 6.7e-05 nM
CCCC(=O)Oc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3ccccc3n2)c1 CHEMBL3666729 IC50 0.000129 nM
CCCC(=O)Nc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3cc(OCC4CC4)ccc3n2)c1 CHEMBL3666755 IC50 0.000182 nM
COCC(=O)Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1 CHEMBL3666742 IC50 0.0017 nM
Oc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1 CHEMBL3666746 IC50 0.002 nM
COC(=O)Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1 CHEMBL3639656 IC50 0.0029 nM
Oc1ccc2nc(-c3ccccc3)nc(Nc3ccc4[nH]ncc4c3)c2c1 CHEMBL3666761 IC50 0.0039 nM
CCCC(=O)Nc1cccc(-c2nc(Nc3ccc4c(cnn4C)c3)c3cc(OCCN(C)C)ccc3n2)c1 CHEMBL3666754 IC50 0.004 nM
CN(C)CCC(=O)Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1 CHEMBL3666741 IC50 0.0053 nM
N=C(N)NCCC[C@@H](NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)CCCCCNC(=O)[C@@H](CCCCN)NC(=O)CCCCCNC(=O)c1ccc(-c2ccnc(N)n2)s1)C(N)=O CHEMBL1077375 Kd 0.0056 nM
c1ccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3cc(OCCN4CCOCC4)ccc3n2)cc1 CHEMBL3666760 IC50 0.0065 nM
O=C(Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1)c1ccccn1 CHEMBL3666740 IC50 0.0083 nM
CNCC(=O)Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1 CHEMBL3666733 IC50 0.017 nM
N=C(N)NCCC[C@@H](NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)CCCCCNC(=O)[C@@H](CCCCN)NC(=O)CCCCCCCN1CCCN(S(=O)(=O)c2cccc3cnccc23)CC1)C(N)=O CHEMBL2023843 Kd 0.02 nM
N=C(N)NCCC[C@@H](NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)CCCCCNC(=O)[C@@H](CCCCN)NC(=O)CCCCCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)C(N)=O CHEMBL525385 Kd 0.021 nM
CC(=O)Oc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1 CHEMBL3666753 IC50 0.023 nM
O=C(CN1CCCC1)Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1 CHEMBL3666735 IC50 0.036 nM
CN(C)C(=O)Nc1ccccc1-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1 CHEMBL3666738 IC50 0.049 nM
N[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cccc(-c5cn[nH]c5)c4)c3)sc2C1 CHEMBL3680709 IC50 0.16 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc(-c5cn[nH]c5)s4)c3)cc2C1 CHEMBL3680738 IC50 0.17 nM
CCC1Oc2cnccc2-c2ccc(C(=O)N[C@H](C)c3cccc(OC)c3)cc21 CHEMBL3578252 IC50 0.18 nM
CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc(-c5ccncc5)s4)c3)sc2C1 CHEMBL3680755 IC50 0.18 nM
CCC1Oc2cnccc2-c2ccc(C(=O)N[C@@H](C)c3cccc(OC)c3)cc21 CHEMBL5287722 IC50 0.18 nM
COc1cc(C(=O)NCc2cccc(C(=O)NC3CCN(C)CC3)c2)ccc1-c1cn[nH]c1 CHEMBL3949136 IC50 0.19 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc(-c5ccncc5)cc4)c3)cc2C1 CHEMBL3680767 IC50 0.195 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(CO)cc1 CHEMBL3792888 Ki 0.2 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc(-c5cnco5)cc4)c3)sc2C1 CHEMBL3680772 IC50 0.2 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cc(-c5ccncc5)n[nH]4)c3)sc2C1 CHEMBL3680805 IC50 0.2 nM
NC[C@@H](C(=O)Nc1ccc2cnccc2c1)c1ccc(CO)cc1 CHEMBL4753043 Ki 0.2 nM
Cc1c(C(=O)N[C@H]2CC3(C2)C[C@H](c2n[nH]c(=O)c4ccccc42)C3)cnn1-c1ccccc1 CHEMBL5397091 IC50 0.2 nM
Nc1ccn(-c2cccc(CNC3CCCC(Nc4ccc5[nH]ncc5c4)C3)c2)c(=O)n1 CHEMBL5414146 IC50 0.2 nM
CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc(-c5cnco5)cc4)c3)sc2C1 CHEMBL3680698 IC50 0.21 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4nnn(-c5nonc5N)c4-c4ccccc4)c3)sc2C1 CHEMBL3680773 IC50 0.21 nM
COc1cccc([C@@H](C)NC(=O)c2ccc3c(c2)C(C)Oc2cnccc2-3)c1 CHEMBL4763198 IC50 0.21 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc(-c5ccncc5)cc4)c3)sc2C1 CHEMBL3680752 IC50 0.22 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cc(-c5ccncc5)n[nH]4)c3)cc2C1 CHEMBL3680759 IC50 0.22 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc(-c5cn[nH]c5)s4)c3)sc2C1 CHEMBL3680768 IC50 0.22 nM
CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cc(-c5ccncc5)n[nH]4)c3)sc2C1 CHEMBL3680736 IC50 0.23 nM
COc1cc(C(=O)NCc2cccc(C(=O)Nc3nc4c(s3)CNCC4)c2)ccc1-c1cn[nH]c1 CHEMBL3902471 IC50 0.23 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 Kd 0.24 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc(-n5ccnc5)cc4)c3)sc2C1 CHEMBL3680771 IC50 0.24 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc(-c5ccncc5)s4)c3)cc2C1 CHEMBL3680735 IC50 0.25 nM
Cc1nc(-c2ccncc2)sc1C(=O)NCc1cccc(C(=O)Nc2nc3c(s2)C[C@@H](N(C)C)CC3)c1 CHEMBL3680804 IC50 0.25 nM
CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc(-c5ccncc5)cc4)c3)sc2C1 CHEMBL3680728 IC50 0.26 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cc5ccc(C(N)=O)cc5n4C)c3)cc2C1 CHEMBL3680740 IC50 0.26 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cn5ccc(C#N)cc5n4)c3)sc2C1 CHEMBL3680748 IC50 0.27 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc(-c5ccncc5)s4)c3)sc2C1 CHEMBL3680765 IC50 0.27 nM
COc1cc(C(=O)N[C@H](CN)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4114628 IC50 0.28 nM
CCCN[C@H]1CCc2nc(NC(=O)c3cccc([C@@H](C)NC(=O)c4ccc(OC)c(OC)c4)c3)sc2C1 CHEMBL3700926 IC50 0.3 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)Nc4cccc(C#N)c4)c3)sc2C1 CHEMBL3700932 IC50 0.3 nM
CN(C)c1ccc(C(=O)Nc2ccc(-c3n[nH]c(=O)c4ccccc34)cc2)cc1 CHEMBL3968772 IC50 0.3 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)c1 CHEMBL3913336 IC50 0.3 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4csc(-c5cccnc5)n4)c3)sc2C1 CHEMBL3680753 IC50 0.32 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cccc(-c5cn[nH]c5)c4)c3)sc2C1 CHEMBL3680769 IC50 0.32 nM
COc1cc(C(=O)NCc2cccc(C(=O)NC3CC3)c2)ccc1-c1cn[nH]c1 CHEMBL3947008 IC50 0.32 nM
Cc1c(C(=O)NCc2cccc(C(=O)Nc3nc4c(s3)C[C@@H](N(C)C)CC4)c2)nnn1-c1nonc1N CHEMBL3680775 IC50 0.33 nM
COc1cc(C(=O)NCc2cccc(C(=O)Nc3nc4c(s3)CN(C)CC4)c2)ccc1-c1cn[nH]c1 CHEMBL3961538 IC50 0.33 nM
O=C(Nc1nc2c(s1)C[C@@H](N1CCOCC1)CC2)c1cccc(CNC(=O)c2cc(-c3ccncc3)n[nH]2)c1 CHEMBL3680786 IC50 0.34 nM
COC(=O)c1cccc(CNC(=O)c2ccc3c(c2)C(C)Oc2cnccc2-3)c1 CHEMBL5289030 IC50 0.34 nM
Cc1nnnn1-c1ccc(C(=O)NCc2cccc(C(=O)Nc3nc4c(s3)C[C@@H](N3CCOCC3)CC4)c2)cc1 CHEMBL3680790 IC50 0.35 nM
COc1cccc([C@@H](C)NC(=O)c2ccc3c(c2)COc2cnccc2-3)c1 CHEMBL4785041 IC50 0.35 nM
COc1cc(C(=O)NC(CN)Cc2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3964418 IC50 0.36 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)NCc1cccc(C(=O)NC2CCN(C)CC2)c1 CHEMBL3925017 IC50 0.36 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc(-c5cnco5)s4)c3)sc2C1 CHEMBL3680766 IC50 0.37 nM
Cc1nc(-c2ccncc2)sc1C(=O)NCc1cccc(C(=O)Nc2nc3c(s2)C[C@@H](N2CCOCC2)CC3)c1 CHEMBL3680787 IC50 0.37 nM
COc1cc(C(=O)NCc2cccc(C(=O)NCC3CC3)c2)ccc1-c1cn[nH]c1 CHEMBL3910152 IC50 0.37 nM
O=C(NCc1cccc(C(=O)Nc2nc3c(s2)C[C@@H](N2CCOCC2)CC3)c1)c1ccc(-n2ccnc2)cc1 CHEMBL3680789 IC50 0.38 nM
CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc5cc(O)ccc5c4)c3)sc2C1 CHEMBL3680701 IC50 0.39 nM
N#Cc1cccc(NC(=O)N2CCC[C@@H]2c2cccc(C(=O)Nc3nc4c(s3)C[C@@H](N)CC4)c2)c1 CHEMBL3700917 IC50 0.39 nM
COc1cccc(CN(CCN(C)C)C(=O)c2nc3ccc(-c4cn[nH]c4)cc3s2)c1 CHEMBL1080279 IC50 0.4 nM
Cc1ccc(C(CN)C(=O)Nc2ccc3cnccc3c2)cc1 CHEMBL3792673 Ki 0.4 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(Cl)cc1 CHEMBL3794104 Ki 0.4 nM
NC[C@@H](C(=O)Nc1ccc2cnccc2c1)c1ccccc1 CHEMBL3793004 Ki 0.4 nM
CCCN[C@H]1CCc2nc(NC(=O)c3cccc([C@@H](C)NC(=O)c4ccc(OC)c(C)c4)c3)sc2C1 CHEMBL3700930 IC50 0.4 nM
CCNC(=O)c1cccc(CNC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)c1 CHEMBL3956238 IC50 0.4 nM
CCc1cc(C(=O)N[C@H](C)c2cccc(OC)c2)ccc1-c1cn[nH]c1 CHEMBL4791701 IC50 0.4 nM
O=C(NCc1cccc(C(=O)Nc2nc3c(s2)C[C@@H](N2CCOCC2)CC3)c1)c1cccc(-c2cn[nH]c2)c1 CHEMBL3680788 IC50 0.41 nM
Cc1nnnn1-c1ccc(C(=O)NCc2cccc(C(=O)Nc3nc4c(s3)C[C@@H](N(C)C)CC4)c2)cc1 CHEMBL3680751 IC50 0.43 nM
O=C(NCc1cccc(C(=O)Nc2nc3c(s2)C[C@@H](N2CCOCC2)CC3)c1)c1ccc(-c2cnco2)cc1 CHEMBL3680784 IC50 0.43 nM
O=C(NCc1cccc(O)c1)Nc1nc(-c2ccncc2)cs1 CHEMBL3218297 IC50 0.45 nM
N[C@@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cccc(-c5cn[nH]c5)c4)c3)sc2C1 CHEMBL3680707 IC50 0.45 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cc5ccc(C(N)=O)cc5[nH]4)c3)cc2C1 CHEMBL3680727 IC50 0.45 nM
CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc(-c5cnco5)s4)c3)sc2C1 CHEMBL3680756 IC50 0.45 nM
COc1cc(C(=O)NCc2cccc(C(=O)NCC(C)(C)O)c2)ccc1-c1cn[nH]c1 CHEMBL3961024 IC50 0.46 nM
CN1CCN(Cc2ccc3c(c2)CN(C(=O)Nc2ccc(-c4c[nH]c(=O)c5ccccc45)cc2)C3)CC1 CHEMBL3892516 Ki 0.49 nM
CCCN[C@H]1CCc2nc(NC(=O)c3cccc([C@@H](C)NC(=O)c4ccc(OC)c(Cl)c4)c3)sc2C1 CHEMBL3700928 IC50 0.5 nM
Cc1cc(C(=O)NCc2cccc(C(=O)NCC3CC3)c2)ccc1-c1cn[nH]c1 CHEMBL3977577 IC50 0.5 nM
CCN1CCC[C@H]1CNC(=O)c1cccc(CNC(=O)c2ccc3c(c2)C(C)Oc2cnccc2-3)c1 CHEMBL4747999 IC50 0.5 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 0.5012 nM
COc1cccc([C@@H](C)NC(=O)c2ccc3c(c2)OCc2cnccc2-3)c1 CHEMBL3578250 IC50 0.51 nM
COc1c(B(O)O)cccc1-c1nc2ccc3[nH]ncc3c2c2c1CCC2 CHEMBL4461288 IC50 0.51 nM
COc1c(B(O)O)cccc1-c1ccc2c(ccc3[nH]ncc32)n1 CHEMBL5287991 IC50 0.51 nM
N#Cc1ccn2cc(C(=O)NCc3cccc(C(=O)Nc4nc5c(s4)C[C@@H](N4CCOCC4)CC5)c3)nc2c1 CHEMBL3680779 IC50 0.52 nM
CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cccc(-c5cn[nH]c5)c4)c3)sc2C1 CHEMBL3680696 IC50 0.53 nM
O=C(Nc1nc(-c2ccncc2)cs1)C1COc2ccccc2O1 CHEMBL510515 IC50 0.56 nM
Cc1c(C(=O)NCc2cccc(C(=O)Nc3nc4c(s3)C[C@@H](N3CCOCC3)CC4)c2)nnn1-c1nonc1N CHEMBL3680781 IC50 0.57 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cc5cc(C#N)ccc5[nH]4)c3)cc2C1 CHEMBL3680739 IC50 0.58 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(O)cc1 CHEMBL3792663 Ki 0.6 nM
N#Cc1cccc(NC(=O)N2CCC[C@@H]2c2cccc(C(=O)Nc3nc4c(s3)C[C@@H](N3CCOCC3)CC4)c2)c1 CHEMBL3700934 IC50 0.6 nM
CCn1c(-c2nonc2N)nc2cncc(C(=O)N3CCC(N)C3)c21 CHEMBL1870106 pKi 0.631 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3c[nH]nc3C)cc2OC)c1 CHEMBL4115244 IC50 0.65 nM
Cc1nnnn1-c1ccc(C(=O)NCc2cccc(C(=O)Nc3nc4c(s3)C[C@@H](N)CC4)c2)cc1 CHEMBL3680716 IC50 0.67 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3cn[nH]c3)c(Cl)c2)c1 CHEMBL4109840 IC50 0.67 nM
N=C(N)NCCC[C@@H](NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)CCCCCNC(=O)[C@@H](CCCCN)NC(=O)CCNC(=O)CNCC(=O)NCCNS(=O)(=O)c1cccc2cnccc12)C(N)=O CHEMBL2023839 Kd 0.7 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(COC(=O)c2cccnc2)cc1 CHEMBL3793788 Ki 0.7 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc2ccccc2c1 CHEMBL3793497 Ki 0.7 nM
CN1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)Nc4ccc(C(N)=O)cc4)c3)sc2C1 CHEMBL3700937 IC50 0.7 nM
COc1ccc2c(c1)CC(C(=O)Nc1ccc(-c3cn[nH]c3)cc1OCCN(C)C)CO2 CHEMBL482336 IC50 0.7 nM
Nc1ccn(-c2ccc(CNC3CCCC(Nc4ccc5[nH]ncc5c4)C3)cc2)c(=O)n1 CHEMBL5409106 IC50 0.7 nM
Cc1cc(C(=O)NCc2cccc(C(=O)NC[C@H]3CCCN3)c2)ccc1-c1cn[nH]c1 CHEMBL4107343 IC50 0.71 nM
COc1cc(C(=O)NCc2cccc(C(N)=O)c2)ccc1-c1cn[nH]c1 CHEMBL3985772 IC50 0.72 nM
Cc1cc(C(=O)N[C@H](CN)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4107839 IC50 0.72 nM
COc1cccc([C@@H](C)NC(=O)c2ccc3c(c2)C(C2CC2)Oc2cnccc2-3)c1 CHEMBL4749267 IC50 0.72 nM
O=C(Nc1nc2c(s1)C[C@@H](N1CCOCC1)CC2)c1cccc(CNC(=O)c2csc(-c3cccnc3)n2)c1 CHEMBL3680778 IC50 0.73 nM
CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc(-c5cn[nH]c5)s4)c3)sc2C1 CHEMBL3680760 IC50 0.77 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(COC(=O)Cc2ccccc2)cc1 CHEMBL3793029 Ki 0.8 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(Cl)cc1Cl CHEMBL3793404 Ki 0.8 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1ccccc1 CHEMBL3770836 Ki 0.8 nM
CN1CCc2nc(NC(=O)c3cccc(OCC(=O)Nc4ccc5[nH]ncc5c4)c3)sc2C1 CHEMBL3700920 IC50 0.8 nM
CCCN[C@H]1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)Nc4cccc(C#N)c4)c3)sc2C1 CHEMBL3700924 IC50 0.8 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)c4cc(-c5ccncc5)[nH]n4)c3)sc2C1 CHEMBL3700969 IC50 0.8 nM
CCNC(=O)c1cccc(CNC(=O)c2ccc3c(c2)COc2cnccc2-3)c1 CHEMBL4790421 IC50 0.8 nM
CCNC(=O)c1cccc(CNC(=O)c2ccc3c(c2)C(C)Oc2cnccc2-3)c1 CHEMBL4758151 IC50 0.8 nM
COC(=O)c1cc(CNC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)ccc1F CHEMBL3928198 IC50 0.82 nM
COc1ccc(F)c(C(C)NC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)c1 CHEMBL3898965 IC50 0.83 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cc5cc(C(N)=O)ccc5[nH]4)c3)cc2C1 CHEMBL3680741 IC50 0.85 nM
COc1cc(C(=O)NCc2cccc(O)c2)ccc1-c1cn[nH]c1 CHEMBL3986802 IC50 0.85 nM
COC(=O)c1cccc(CNC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)c1 CHEMBL3928809 IC50 0.85 nM
CNC(=O)c1cccc(CNC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)c1 CHEMBL3958305 IC50 0.85 nM
CCN1CCCC1CNC(=O)c1cccc(CNC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)c1 CHEMBL3957651 IC50 0.85 nM
CN1CC(NC(=O)c2cccc(CNC(=O)c3ccc4c(c3)COc3cnccc3-4)c2)C1 CHEMBL4749353 IC50 0.85 nM
Cc1cc(C(=O)NCc2cccc(C(=O)NC3CC3)c2)ccc1-c1cn[nH]c1 CHEMBL3939581 IC50 0.86 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4csc(-c5ccncc5)n4)c3)sc2C1 CHEMBL3680774 IC50 0.87 nM
N#Cc1ccc2cc(C(=O)NCc3cccc(C(=O)Nc4nc5c(s4)C[C@@H](N4CCOCC4)CC5)c3)[nH]c2c1 CHEMBL3680792 IC50 0.87 nM
CN(C)CCCNC(=O)c1ccc2c(c1)CC(c1nc3ccc(-c4cn[nH]c4)cc3s1)CO2 CHEMBL1079921 IC50 0.9 nM
Cc1cc(C)cc(C(=O)OCc2ccc(C(CN)C(=O)Nc3ccc4cnccc4c3)cc2)c1 CHEMBL3792412 Ki 0.9 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1cccc(Cl)c1 CHEMBL3793505 Ki 0.9 nM
O=C(Nc1nc2c(s1)C[C@@H](N1CCOCC1)CC2)c1cccc(CNC(=O)c2csc(-c3ccncc3)n2)c1 CHEMBL3680785 IC50 0.93 nM
COc1cc(C(=O)NCc2cccc(S(N)(=O)=O)c2)ccc1-c1cn[nH]c1 CHEMBL3915928 IC50 0.99 nM
NC(C(=O)Nc1ccc(-c2cn[nH]c2)cc1)c1ccc(Cl)cc1 CHEMBL1215022 IC50 1.0 nM
O=C(NC1CC1)c1ccc2c(c1)CC(c1nc3ccc(-c4cn[nH]c4)cc3c(=O)[nH]1)CO2 CHEMBL1684208 IC50 1.0 nM
COc1cc(-c2cn[nH]c2)cc2c(=O)[nH]c(C3COc4ccc(F)cc4C3)nc12 CHEMBL1684225 IC50 1.0 nM
COc1cccc(OCc2nc3c(OC)cc(-c4cn[nH]c4)cc3c(=O)[nH]2)c1 CHEMBL1684229 IC50 1.0 nM
COc1cccc(CN(CCCN(C)C)C(=O)c2cn(C)c3cc(-c4cn[nH]c4)ccc23)c1 CHEMBL1922126 IC50 1.0 nM
COc1cccc(CN(CCN(C)C)C(=O)c2cn(C)c3cc(-c4cn[nH]c4)ccc23)c1 CHEMBL1922127 IC50 1.0 nM
COc1cccc(CNC(=O)c2cn(CCCO)c3cc(-c4cn[nH]c4)ccc23)c1 CHEMBL1922128 IC50 1.0 nM
COc1cccc([C@@H](C)NC(=O)c2cc3ccc(-c4cn[nH]c4)nc3[nH]2)c1 CHEMBL1923181 IC50 1.0 nM
CCN(Cc1cccc(OC)c1)C(=O)Nc1ccc(-c2cn[nH]c2)cc1O[C@H]1CCN(C)C1 CHEMBL2332060 IC50 1.0 nM
O=C(Nc1ccc(-c2cn[nH]c2)cc1)NC(CCO)c1ccccc1 CHEMBL2332057 IC50 1.0 nM
COc1cccc(CN(CCN(C)C)C(=O)Nc2ccc(-c3cn[nH]c3)cc2)c1 CHEMBL2332068 IC50 1.0 nM
COc1cccc(CN(CCO)C(=O)Nc2ccc(-c3cn[nH]c3)cc2)c1 CHEMBL2332065 IC50 1.0 nM
COc1cccc(CN(C(=O)Nc2ccc(-c3cn[nH]c3)cc2)C2CC2)c1 CHEMBL2332099 IC50 1.0 nM
CCN(Cc1cccc(OC)c1)C(=O)Nc1ccc(-c2cn[nH]c2)cc1 CHEMBL2332098 IC50 1.0 nM
COc1cccc(CN(C)C(=O)Nc2ccc(-c3cn[nH]c3)cc2)c1 CHEMBL2332097 IC50 1.0 nM
O=c1[nH]c([C@@H]2CNC[C@H]2c2ccccc2)nc2ccc(-c3cn[nH]c3)cc12 CHEMBL2334292 IC50 1.0 nM
NCc1ccc(C(=O)Nc2ccncc2F)cc1-c1cccc(NC(=O)c2ccc(C(=O)O)cc2)c1 CHEMBL3426732 IC50 1.0 nM
NCC(=O)Oc1ccc(C(CN)C(=O)Nc2ccc3cnccc3c2)cc1 CHEMBL3792435 Ki 1.0 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1cccc2ccccc12 CHEMBL3793296 Ki 1.0 nM
Cc1cc(C(CN)C(=O)Nc2ccc3cnccc3c2)ccc1O CHEMBL3794298 Ki 1.0 nM
Cc1ccccc1C(CN)C(=O)Nc1ccc2cnccc2c1 CHEMBL3793489 Ki 1.0 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(F)cc1 CHEMBL3792921 Ki 1.0 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1cccc(F)c1 CHEMBL3792666 Ki 1.0 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1ccccc1F CHEMBL3794270 Ki 1.0 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc(-c5cnco5)s4)c3)cc2C1 CHEMBL3680731 IC50 1.0 nM
N#Cc1cccc(NC(=O)N2CCC[C@@H]2c2cccc(C(=O)Nc3nc4c(s3)C[C@H](N)CC4)c2)c1 CHEMBL3700919 IC50 1.0 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3ccncc3F)cc2)c1 CHEMBL4472858 IC50 1.0 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3ccncc3)cc2N2CCC(CN)CC2)c1 CHEMBL4434688 IC50 1.0 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3ccncc3)cc2)c1 CHEMBL4448806 IC50 1.0 nM
COc1cccc(Cn2cnc3sc(-c4ccnc(N)c4)cc3c2=O)c1 CHEMBL4649403 IC50 1.0 nM
COc1cccc(Cn2cnc3sc(-c4ccnc5[nH]ccc45)cc3c2=O)c1 CHEMBL4638815 IC50 1.0 nM
O=c1c2cc(-c3ccnc4[nH]ccc34)sc2ncn1Cc1cccc(F)c1 CHEMBL4645138 IC50 1.0 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2F)c1 CHEMBL4111518 IC50 1.0 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3cn[nH]c3)c(C)c2)c1 CHEMBL4111655 IC50 1.0 nM
Cc1ccc(C(=O)OCc2ccc([C@@H](CN)C(=O)Nc3ccc4cnccc4c3)cc2)c(C)c1 CHEMBL4796289 Ki 1.0 nM
Cc1c[nH]c2nccc(Oc3c(F)cc(Nc4cc(Cl)nc(N)n4)cc3F)c12 CHEMBL1971943 IC50 1.0 nM
Cc1ccc(C(=O)OCc2ccc([C@@H](CN)C(=O)Nc3ccc4cnccc4c3)cc2)c(C)c1 CHEMBL4594250 Ki 1.0 nM
COc1cccc(CNC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)c1 CHEMBL3951271 IC50 1.0 nM
Nc1nc(Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)cc(-c2ccncc2)n1 CHEMBL5274003 IC50 1.0 nM
N#Cc1c[nH]c2nccc(Oc3c(F)cc(Nc4ccnc(N)n4)cc3F)c12 CHEMBL5270382 IC50 1.0 nM
O=C(Nc1ccc(-c2n[nH]c(=O)c3ccccc23)cc1)N1CCc2ccccc21 CHEMBL5289256 IC50 1.0 nM
Nc1ccn(-c2cccc(CN3CCCC(Nc4ccc5[nH]ncc5c4)C3)c2)c(=O)n1 CHEMBL5416265 IC50 1.0 nM
COc1cc(C(=O)NC(C)c2c(F)cccc2F)ccc1-c1cn[nH]c1 CHEMBL3946084 IC50 1.01 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)N[C@@H](c1ccccc1)[C@H](O)CO CHEMBL4107177 IC50 1.09 nM
COC(=O)Cc1cccc(NC(=O)c2cccc(-c3cc(C(=O)Nc4ccncc4F)ccc3CN)c2)c1 CHEMBL3426623 IC50 1.1 nM
COC(=O)c1cccc(NC(=O)c2cccc(-c3cc(C(=O)Nc4ccncc4F)ccc3CN)c2)c1 CHEMBL3426622 IC50 1.1 nM
N[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4csc(-c5ccncc5)n4)c3)sc2C1 CHEMBL3680713 IC50 1.1 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3cn[nH]c3)cc2OC)c1 CHEMBL3907133 IC50 1.1 nM
COc1cc(C(=O)NCc2cccc(C(=O)NC3(C)CC3)c2)ccc1-c1cn[nH]c1 CHEMBL3920062 IC50 1.14 nM
CCn1c2cnccc2c2ccc(C(=O)N[C@H](C)c3cccc(OC)c3)cc21 CHEMBL3578253 IC50 1.16 nM
CC(N)c1ccc(C(=O)Nc2ccncc2)cc1-c1ccc(F)cc1 CHEMBL2440742 IC50 1.2 nM
COC(=O)c1cccc(NC(=O)c2cccc(-c3cc(C(=O)Nc4ccncc4F)ccc3CN)c2)c1F CHEMBL3426641 IC50 1.2 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(F)c(F)c1 CHEMBL3793969 Ki 1.2 nM
N[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cccc(-c5cccnc5)c4)c3)sc2C1 CHEMBL3680719 IC50 1.2 nM
Cc1nc(-c2ccncc2)sc1C(=O)NCc1cccc(C(=O)Nc2nc3c(s2)CN(C)CC3)c1 CHEMBL3680737 IC50 1.2 nM
Cc1sc(-c2ccncc2)nc1C(=O)NCc1cccc(C(=O)Nc2nc3c(s2)CN(C)CC3)c1 CHEMBL3680729 IC50 1.2 nM
CCOc1ccc2c(c1)N(C(=O)Cc1ccc(-c3n[nH]c(=O)c4ccccc34)cc1)CC2 CHEMBL3953195 IC50 1.2 nM
O=C(Nc1ccc(-c2c[nH]c(=O)c3ccccc23)cc1)N1CCc2ccccc21 CHEMBL3921800 IC50 1.2 nM
COc1cc(C(=O)NCc2cccc(C(=O)O)c2)ccc1-c1cn[nH]c1 CHEMBL3921882 IC50 1.2 nM
COc1ccc2c(c1)CC(C(=O)Nc1ccc(-c3c[nH]nc3C)cc1OCCN(C)C)CO2 CHEMBL4570327 IC50 1.2 nM
O=C(N[C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1)c1cc2c(s1)CCCn1ncc(Br)c1-2 CHEMBL5408482 IC50 1.2 nM
Cc1nc(-c2ccncc2)sc1C(=O)NCc1cccc(C(=O)Nc2ccc3c(c2)CN(C)CC3)c1 CHEMBL3680746 IC50 1.25 nM
COc1cc(C(=O)NC(C)c2ccccc2F)ccc1-c1cn[nH]c1 CHEMBL3965274 IC50 1.27 nM
CCNC[C@@H](NC(=O)c1ccc(-c2cn[nH]c2)c(OC)c1)c1c(F)cccc1F CHEMBL4107997 IC50 1.29 nM
NCc1ccc(C(=O)Nc2ccncc2F)cc1-c1cccc(C(=O)Nc2ccc(CC(=O)OC3CCCC3)cc2)c1 CHEMBL3426727 IC50 1.3 nM
NCc1ccc(C(=O)Nc2ccncc2F)cc1-c1cccc(C(=O)Nc2ccc(CC(=O)OC3CCC3)cc2)c1 CHEMBL3426726 IC50 1.3 nM
COc1ccc(C(CN)C(=O)Nc2ccc3cnccc3c2)cc1 CHEMBL3793516 Ki 1.3 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1cccc(O)c1 CHEMBL3792734 Ki 1.3 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1ccccc1Cl CHEMBL3792549 Ki 1.3 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)c4csc(-c5cccnc5)n4)c3)sc2C1 CHEMBL3700966 IC50 1.3 nM
COc1cc(C(=O)N[C@H](C)c2ccccc2F)ccc1-c1cn[nH]c1 CHEMBL4753754 IC50 1.3 nM
CNC(=O)c1cccc(CNC(=O)c2ccc3c(c2)COc2cnccc2-3)c1 CHEMBL4746567 IC50 1.3 nM
O=C(N[C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1)c1cc2c(s1)OCCn1ncc(Cl)c1-2 CHEMBL5437264 IC50 1.3 nM
CC(C)(C)c1ccn(-c2cccc(CN[C@H]3CCC[C@H](Nc4ccc5[nH]ncc5c4)C3)c2)c(=O)c1 CHEMBL5435627 IC50 1.3 nM
COc1cc(C(=O)N[C@H](C)c2ccccc2Cl)ccc1-c1cn[nH]c1 CHEMBL3890863 IC50 1.31 nM
COc1cc(C(=O)NCc2ccc(Cl)cc2F)ccc1-c1cn[nH]c1 CHEMBL3938495 IC50 1.36 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3cn[nH]c3)c(C(F)(F)F)c2)c1 CHEMBL4114533 IC50 1.36 nM
O=C(Nc1ccc(-c2c[nH]c(=O)c3ccccc23)cc1)N1Cc2ccc(CN3CCCC3)cc2C1 CHEMBL3976744 Ki 1.39 nM
N=C(N)NCCC[C@@H](NC(=O)[C@@H](CCCNC(=N)N)NC(=O)CCCCCNC(=O)[C@@H](CCCCN)NC(=O)CCCCCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)C(N)=O CHEMBL297394 Kd 1.4 nM
NCc1ccc(C(=O)Nc2ccncc2F)cc1-c1cccc(C(=O)OCCO)c1 CHEMBL2440735 IC50 1.4 nM
CCCOC(=O)c1cccc(-c2cc(C(=O)Nc3ccncc3)ccc2CN)c1 CHEMBL2440745 IC50 1.4 nM
COC(=O)c1ccc(F)c(C(=O)Nc2cccc(-c3cc(C(=O)Nc4ccncc4F)ccc3CN)c2)c1 CHEMBL3426639 IC50 1.4 nM
NCc1ccc(C(=O)Nc2ccncc2F)cc1-c1cccc(C(=O)Nc2cccc(C(=O)OC3CCCC3)c2F)c1 CHEMBL3426642 IC50 1.4 nM
Cc1nnnn1-c1ccc(C(=O)NCc2cccc(C(=O)Nc3nc4c(s3)C[C@H](N)CC4)c2)cc1 CHEMBL3680714 IC50 1.4 nM
O=C(N[C@@H]1CNCC[C@H]1c1cccc(F)c1)c1cc2c(s1)OCCn1ncc(Br)c1-2 CHEMBL5428749 IC50 1.4 nM
O=C(N[C@@H]1CNCC[C@H]1c1cc(F)cc(F)c1)c1cc2c(s1)OCCn1ncc(Br)c1-2 CHEMBL5421280 IC50 1.4 nM
NC[C@@H](C(=O)Nc1ccc2cnsc2c1)c1ccc(CO)cc1 CHEMBL5435792 IC50 1.45 nM
COc1cc(C(=O)N[C@H](C)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3936323 IC50 1.48 nM
O=C(Nc1ccc(-c2c[nH]cn2)cc1)C1COc2ccccc2O1 CHEMBL485214 IC50 1.5 nM
N=C(N)NCCC[C@@H](NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)CCCCCNC(=O)[C@@H](CCCCN)NC(=O)CNCC(=O)NCCNS(=O)(=O)c1cccc2cnccc12)C(N)=O CHEMBL2023838 Kd 1.5 nM
N=C(N)NCCC[C@@H](NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)CCCCCNC(=O)[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)C(N)=O CHEMBL279185 Kd 1.5 nM
COCCCOC(=O)c1cccc(-c2cc(C(=O)Nc3ccncc3)ccc2CN)c1 CHEMBL2440733 IC50 1.5 nM
NCc1ccc(C(=O)Nc2ccncc2F)cc1-c1cccc(C(=O)Nc2cccc(CC(=O)O)c2)c1 CHEMBL3426627 IC50 1.5 nM
NC(C(=O)Nc1ccc2cnccc2c1)c1ccccc1 CHEMBL3770730 IC50 1.5 nM
NCCC(C(=O)Nc1ccc2cnccc2c1)c1ccccc1 CHEMBL3793538 Ki 1.5 nM
O=C(N[C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1)c1cc2c(s1)OCCn1ncc(Br)c1-2 CHEMBL5406146 IC50 1.5 nM
COC(=O)c1ccc(F)c(NC(=O)c2cccc(-c3cc(C(=O)Nc4ccncc4F)ccc3CN)c2)c1 CHEMBL3426633 IC50 1.6 nM
CCCCC(=O)OCc1ccc(C(CN)C(=O)Nc2ccc3cnccc3c2)cc1 CHEMBL3793688 Ki 1.6 nM
Cc1nccn1-c1ccc(C(=O)NCc2cccc(C(=O)Nc3ccc4c(c3)CN(C)CC4)c2)cc1 CHEMBL3680801 IC50 1.6 nM
CCOc1cc(-c2cn[nH]c2)ccc1C(=O)N[C@H](C)c1cccc(OC)c1 CHEMBL4111653 IC50 1.6 nM
COc1cc(C(=O)N[C@H](C)c2c(F)cccc2F)ccc1-c1cn[nH]c1 CHEMBL4746508 IC50 1.6 nM
Cc1cncc2cccc(S(=O)(=O)N3CCCNC[C@@H]3C)c12 CHEMBL406821 Ki 1.6 nM
COc1cccc(CNC(=O)c2cc3ccc(-c4cn[nH]c4)cc3[nH]2)c1 CHEMBL1922026 IC50 1.6 nM
CC(C)(C)c1ccn(-c2cccc(CN[C@H]3CCC[C@@H](Nc4ccc5[nH]ncc5c4)C3)c2)c(=O)c1 CHEMBL5439783 IC50 1.6 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(COC(=O)c2ccccc2)cc1 CHEMBL3792969 Ki 1.7 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cn5cc(C#N)ccc5n4)c3)sc2C1 CHEMBL3680749 IC50 1.7 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4nnn(-c5nonc5N)c4-c4ccccc4)c3)cc2C1 CHEMBL3680762 IC50 1.7 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(OCC(=O)Nc4ccc(C#N)cc4)c3)sc2C1 CHEMBL3700907 IC50 1.7 nM
CN1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)c4ccc(-c5ccncc5)cc4)c3)sc2C1 CHEMBL3700922 IC50 1.7 nM
N#Cc1ccn2cc(C(=O)N3CCC[C@@H]3c3cccc(C(=O)Nc4nc5c(s4)C[C@@H](N4CCOCC4)CC5)c3)nc2c1 CHEMBL3700958 IC50 1.7 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)c4cn5cc(C(N)=O)ccc5n4)c3)sc2C1 CHEMBL3700975 IC50 1.7 nM
O=C(N[C@@H]1CNCC[C@H]1c1cc(F)c(F)c(F)c1)c1cc2c(s1)OCCn1ncc(Cl)c1-2 CHEMBL5438374 IC50 1.7 nM
O=c1cc(-c2ccccc2)ccn1-c1cccc(CN[C@H]2CCC[C@@H](Nc3ccc4[nH]ncc4c3)C2)c1 CHEMBL5403316 IC50 1.7 nM
CN(C)Cc1ccc2c(c1)CN(C(=O)Nc1ccc(-c3c[nH]c(=O)c4ccccc34)cc1)C2 CHEMBL3933101 Ki 1.74 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)NCc1ccc(F)cc1Cl CHEMBL3904054 IC50 1.75 nM
CCCOC(=O)c1cccc(C(=O)Nc2cccc(-c3cc(C(=O)Nc4ccncc4F)ccc3CN)c2)c1 CHEMBL3426638 IC50 1.8 nM
NCc1ccc(C(=O)Nc2ccncc2F)cc1-c1cccc(C(=O)Nc2ccc(CC(=O)O)cc2)c1 CHEMBL3426629 IC50 1.8 nM
COC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]ccc34)CC2)c1 CHEMBL3613610 IC50 1.8 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(OC(=O)Cc2ccccc2)cc1 CHEMBL3792599 Ki 1.8 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(C(F)(F)F)cc1 CHEMBL3793235 Ki 1.8 nM
N[C@@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4csc(-c5ccncc5)n4)c3)sc2C1 CHEMBL3680711 IC50 1.8 nM
Cc1c(C(=O)NCc2cccc(C(=O)Nc3nc4c(s3)CN(C)CC4)c2)nnn1-c1nonc1N CHEMBL3680720 IC50 1.8 nM
CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4nnn(-c5nonc5N)c4-c4ccccc4)c3)sc2C1 CHEMBL3680721 IC50 1.8 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)NCc1cccc(S(N)(=O)=O)c1 CHEMBL3985681 IC50 1.86 nM
COc1cc(C(=O)NC(CN)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3955270 IC50 1.89 nM
N[C@@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cccc(-c5cccnc5)c4)c3)sc2C1 CHEMBL3680718 IC50 1.9 nM
CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc(-n5ccnc5)cc4)c3)sc2C1 CHEMBL3680694 IC50 1.9 nM
CN1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)c4cccc(-c5cn[nH]c5)c4)c3)sc2C1 CHEMBL3700956 IC50 1.9 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)c4cccc(-c5cn[nH]c5)c4)c3)sc2C1 CHEMBL3700977 IC50 1.9 nM
COc1cc(C(=O)N[C@H](CNS(C)(=O)=O)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4107374 IC50 1.9 nM
O=C(N[C@@H]1CNCC[C@H]1c1cccc(F)c1)c1cc2c(s1)OCCn1ncc(Cl)c1-2 CHEMBL5426560 IC50 1.9 nM
COc1cc(C(=O)NC(CCN(C)C)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3901295 IC50 1.93 nM
COc1cc(C(=O)N[C@@H](c2ccccc2)[C@H](O)CO)ccc1-c1cn[nH]c1 CHEMBL4107687 IC50 1.98 nM
NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1973720 pKi 1.995 nM
O=C(Nc1ccc(-c2cn[nH]c2)cc1)C1COc2ccccc2O1 CHEMBL519123 IC50 2.0 nM
O=C(Nc1ccc(-c2cn[nH]c2)cc1)C1COc2ccccc2C1 CHEMBL455658 IC50 2.0 nM
COc1cc(NC(=O)C2COc3ccc(Cl)cc3C2)ccc1-c1cn[nH]c1 CHEMBL482363 IC50 2.0 nM
c1ccc2c(c1)CC(c1nc3ccc(-c4ccncc4)cc3[nH]1)CO2 CHEMBL452734 IC50 2.0 nM
COc1ccc2c(c1)CC(c1nc3ccc(-c4ccnc(N)n4)cc3[nH]1)CO2 CHEMBL454638 IC50 2.0 nM
COc1ccc2c(c1)CC(c1nc3ccc(-c4ccnc(N)n4)cc3o1)CO2 CHEMBL461338 IC50 2.0 nM
O=C(Nc1cc2cc[nH]c(=O)c2cc1Cl)C1CNCC1c1cccc(Br)c1 CHEMBL1083747 IC50 2.0 nM
CCN1Cc2ccccc2C[C@@H]1C(=O)Nc1cc(F)c(-c2cn[nH]c2)cc1OCCN(C)C CHEMBL1215526 IC50 2.0 nM
NC(Cc1ccc(Cl)cc1)C(=O)Nc1ccc(-c2cn[nH]c2)cc1 CHEMBL1215021 IC50 2.0 nM
O=c1[nH]c(C2CCc3ccccc3O2)nc2ccc(-c3cn[nH]c3)cc12 CHEMBL1684196 IC50 2.0 nM
COc1ccc2c(c1)CC(c1nc3ccc(-c4cn[nH]c4)cc3c(=O)[nH]1)CO2 CHEMBL1684200 IC50 2.0 nM
COc1ccc2c(c1)CC(c1nc3c(OC)cc(-c4cn[nH]c4)cc3c(=O)[nH]1)CO2 CHEMBL1684221 IC50 2.0 nM
COc1cc(-c2cn[nH]c2)cc2c(=O)[nH]c(C3COc4ccccc4O3)nc12 CHEMBL1684228 IC50 2.0 nM
COc1cccc(CNC(=O)c2cc3ccc(-c4cn[nH]c4)nc3[nH]2)c1 CHEMBL1922034 IC50 2.0 nM
COc1cccc(CN(C)C(=O)c2c[nH]c3cc(-c4cn[nH]c4)ccc23)c1 CHEMBL1922046 IC50 2.0 nM
COc1cccc(CNC(=O)c2c[nH]c3nc(-c4cn[nH]c4)ccc23)c1 CHEMBL1922132 IC50 2.0 nM
COc1cccc(CNC(=O)c2c[nH]c3cc(-c4ccncc4)ccc23)c1 CHEMBL1923167 IC50 2.0 nM
COc1cccc(CN(CCN(C)C)C(=O)Nc2ccc(-c3cn[nH]c3)cn2)c1 CHEMBL2332063 IC50 2.0 nM
CN(C)CCC(NC(=O)Nc1ccc(-c2cn[nH]c2)cc1)c1ccccc1 CHEMBL2332059 IC50 2.0 nM
O=C(Nc1ccc(-c2cn[nH]c2)cc1)NC(CO)c1ccccc1 CHEMBL2332058 IC50 2.0 nM
O=C(Nc1ccc(-c2cn[nH]c2)cc1)NC(CCO)c1cccc(F)c1 CHEMBL2332056 IC50 2.0 nM
COc1cccc(C(CCO)NC(=O)Nc2ccc(-c3cn[nH]c3)cc2)c1 CHEMBL2332076 IC50 2.0 nM
O=c1[nH]c([C@@H]2CNC[C@H]2c2ccc(C(F)(F)F)cc2)nc2ccc(-c3cn[nH]c3)cc12 CHEMBL2333899 IC50 2.0 nM
O=c1[nH]c([C@@H]2CNC[C@H]2c2ccc(F)cc2)nc2ccc(-c3cn[nH]c3)cc12 CHEMBL2333897 IC50 2.0 nM
COc1cccc(CNC(=O)Nc2ccc(-c3c[nH]nc3C)cc2)c1 CHEMBL3402447 IC50 2.0 nM
COc1cccc(CNC(=O)Nc2ccc(-c3cn[nH]c3)cc2)c1 CHEMBL3402466 pIC50 2.0 nM
NCc1ccc(C(=O)Nc2ccncc2F)cc1-c1cccc(C(=O)Nc2cc(C(=O)O)ccc2F)c1 CHEMBL3426643 IC50 2.0 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(OCc2ccccc2)cc1 CHEMBL3792593 Ki 2.0 nM
COc1cccc(C(CN)C(=O)Nc2ccc3cnccc3c2)c1 CHEMBL3793153 Ki 2.0 nM
NCC(C(=O)Nc1ccc2c(O)nccc2c1)c1ccc(F)cc1 CHEMBL3792581 Ki 2.0 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc5cc(O)ccc5c4)c3)cc2C1 CHEMBL3680708 IC50 2.0 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)c4csc(-c5ccncc5)n4)c3)sc2C1 CHEMBL3700968 IC50 2.0 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)c4ccc5cc(O)ccc5c4)c3)sc2C1 CHEMBL3700972 IC50 2.0 nM
COc1cccc(CNC(=O)N(C)c2nc(-c3ccncc3)cs2)c1 CHEMBL3218275 IC50 2.0 nM
O=C(Cc1cccc(OCCCN2CCNCC2)c1)Nc1nc(-c2ccncc2)cs1 CHEMBL4245507 IC50 2.0 nM
COc1cccc(Cn2cnc3sc(-c4ccc5[nH]ncc5c4)cc3c2=O)c1 CHEMBL4636499 IC50 2.0 nM
COc1ccc(Cn2cnc3sc(-c4ccnc5[nH]ccc45)cc3c2=O)cc1 CHEMBL4638636 IC50 2.0 nM
C[C@@H]1CN(c2ccncc2F)CCN1C(=O)N[C@H](C)c1cccn2nccc12 CHEMBL5192610 IC50 2.0 nM
CN(C)C(C(=O)Nc1ccc2c(=O)[nH]ccc2c1)c1ccsc1 CHEMBL3545065 Ki 2.0 nM
COc1ccc2c(c1)CN(c1nccc(Nc3ccc(-c4cn[nH]c4)cc3)n1)C2 CHEMBL5281966 IC50 2.0 nM
O=C1C(Nc2cccc(OC(F)F)c2)CCN1c1ccc(-c2n[nH]c(=O)c3ccccc23)cc1 CHEMBL5273553 IC50 2.0 nM
NC(=O)c1ccccc1O[C@H]1CC2(C1)C[C@H](N1C(=O)NC(c3ccccc3Cl)C1=O)C2 CHEMBL5424408 IC50 2.0 nM
Nc1ccn(-c2ccc(CN3CCCCC(Nc4ccc5[nH]ncc5c4)C3)cc2)c(=O)n1 CHEMBL5397611 IC50 2.0 nM
COc1cc(C(=O)NC(c2ccccc2F)C(C)(C)O)ccc1-c1cn[nH]c1 CHEMBL3962377 IC50 2.07 nM
COC(=O)c1cccc(C(=O)Nc2cccc(-c3cc(C(=O)Nc4ccncc4F)ccc3CN)c2)c1 CHEMBL3426637 IC50 2.1 nM
CCCOC(=O)c1ccc(F)c(NC(=O)c2cccc(-c3cc(C(=O)Nc4ccncc4F)ccc3CN)c2)c1 CHEMBL3426634 IC50 2.1 nM
CN1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)c4ccc5cc(O)ccc5c4)c3)sc2C1 CHEMBL3700935 IC50 2.1 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)c4ccc(-c5cnco5)cc4)c3)sc2C1 CHEMBL3700965 IC50 2.1 nM
O=C(Nc1ccc(-c2n[nH]c(=O)c3ccccc23)cc1)c1ccc(N2CCCCC2)cc1 CHEMBL3935660 IC50 2.1 nM
COc1cc(C(=O)N[C@@H](c2ccccc2F)C(C)(C)O)ccc1-c1cn[nH]c1 CHEMBL4757844 IC50 2.1 nM
COc1cc(C(=O)N[C@H](CO)c2c(F)cccc2F)ccc1-c1cn[nH]c1 CHEMBL4799704 IC50 2.1 nM
COc1cc(C(=O)NCc2ccccc2C)ccc1-c1cn[nH]c1 CHEMBL3952342 IC50 2.13 nM
COc1cc(C(=O)NC(CCO)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3957255 IC50 2.17 nM
COc1cc(C(=O)NC(CO)c2ccccc2F)ccc1-c1cn[nH]c1 CHEMBL3947211 IC50 2.17 nM
COCCOC(=O)c1ccc(F)c(C(=O)Nc2cccc(-c3cc(C(=O)Nc4ccncc4F)ccc3CN)c2)c1 CHEMBL3426640 IC50 2.2 nM
NCC(C(=O)Nc1ccc2c(O)nccc2c1)c1ccccc1 CHEMBL3792781 Ki 2.2 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cc5ccc(C#N)cc5[nH]4)c3)cc2C1 CHEMBL3680725 IC50 2.2 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)c4nnn(-c5nonc5N)c4-c4ccccc4)c3)sc2C1 CHEMBL3700941 IC50 2.2 nM
O=C(Nc1ccc(-c2n[nH]c(=O)c3ccccc23)cc1)N1Cc2ccc(CN3CCC3)cc2C1 CHEMBL3906668 Ki 2.2 nM
COc1cc(C(=O)NCc2cc(Cl)ccc2Cl)ccc1-c1cn[nH]c1 CHEMBL3922088 IC50 2.2 nM
COc1cc(C(=O)NC(C)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3891623 IC50 2.24 nM
COc1cc(C(=O)NCc2ccccc2Cl)ccc1-c1cn[nH]c1 CHEMBL3960736 IC50 2.28 nM
COc1cccc(CNC(=O)c2ccc(-c3cn[nH]c3)c(C)c2)c1 CHEMBL3967606 IC50 2.28 nM
C[C@@H](N)c1ccc(C(=O)Nc2ccnc3[nH]ccc23)cc1 CHEMBL3794409 Ki 2.3 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)c4ccc5[nH]c(=O)ccc5c4)c3)sc2C1 CHEMBL3700978 IC50 2.3 nM
NC(=O)c1ccc2nc(C(=O)N3CCC[C@@H]3c3cccc(C(=O)Nc4nc5c(s4)C[C@@H](N4CCOCC4)CC5)c3)cn2c1 CHEMBL3704375 IC50 2.3 nM
O=C(Nc1ccc(-c2n[nH]c(=O)c3ccccc23)cc1)N1Cc2ccc(CN3CCCC3)cc2C1 CHEMBL3967932 Ki 2.3 nM
COc1cc(C(=O)N[C@H](CO)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3955445 IC50 2.3 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3cn[nH]c3)cc2OCCO)c1 CHEMBL4114112 IC50 2.31 nM
COc1cc(C(=O)N[C@@H](C)c2cccc3ccccc23)ccc1-c1cn[nH]c1 CHEMBL3969951 IC50 2.32 nM
O=C(Nc1ccc(-c2n[nH]c(=O)c3cccc(F)c23)cc1)N1Cc2ccccc2C1 CHEMBL3956902 Ki 2.37 nM
O=C(Nc1ccc(-c2n[nH]c(=O)c3ccccc23)cc1)N1Cc2ccc(F)cc2C1 CHEMBL3896775 Ki 2.4 nM
COc1cccc([C@@H](C)NC(=O)c2ccc3c(c2)COc2cncnc2-3)c1 CHEMBL4797403 IC50 2.4 nM
C[C@@H](N)c1ccc(C(=O)Nc2ccnc3[nH]ccc23)cc1 CHEMBL571948 Ki 2.4 nM
O=C(Nc1ccc(-c2n[nH]c(=O)c3c2CCCC3)cc1)N1Cc2ccc(F)cc2C1 CHEMBL5278707 Ki 2.4 nM
COc1cc(CNC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)ccc1F CHEMBL3985775 IC50 2.41 nM
CCN(CC)Cc1ccc2c(c1)CN(C(=O)Nc1ccc(-c3c[nH]c(=O)c4ccccc34)cc1)C2 CHEMBL3957123 Ki 2.45 nM
N=C(N)NCCC[C@@H](NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)CCCCCNCCNS(=O)(=O)c1cccc2cnccc12)C(N)=O CHEMBL2023714 pIC50 2.455 nM
COc1cc(C(=O)NCc2c(F)ccc(F)c2F)ccc1-c1cn[nH]c1 CHEMBL3965554 IC50 2.46 nM
COc1ccc(F)c(CNC(=O)c2ccc(-c3cn[nH]c3)c(OC)c2)c1 CHEMBL3892122 IC50 2.47 nM
CN(C)c1nc([C@@H]2CNC[C@H]2c2ccccc2)nc2ccc(-c3cn[nH]c3)cc12 CHEMBL2333879 IC50 2.5 nM
NCc1ccc(C(=O)Nc2ccncc2F)cc1-c1cccc(C(=O)OCC2CCCO2)c1 CHEMBL2440737 IC50 2.5 nM
COC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]cc(C#N)c34)CC2)c1 CHEMBL3613620 IC50 2.5 nM
CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cn5ccc(C#N)cc5n4)c3)sc2C1 CHEMBL3680732 IC50 2.5 nM
CN1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)c4cn5cc(C(N)=O)ccc5n4)c3)sc2C1 CHEMBL3700954 IC50 2.5 nM
O=C(Nc1nc2c(s1)C[C@@H](N1CCOCC1)CC2)c1cccc([C@H]2CCCN2C(=O)c2ccc(-c3cnco3)cc2)c1 CHEMBL3704372 IC50 2.5 nM
O=C(Nc1nc2c(s1)C[C@@H](N1CCOCC1)CC2)c1cccc([C@H]2CCCN2C(=O)c2ccc3cc(O)ccc3c2)c1 CHEMBL3704378 IC50 2.5 nM
O=C(Nc1nc2c(s1)C[C@@H](N1CCOCC1)CC2)c1cccc([C@H]2CCCN2C(=O)c2cccc(-c3cn[nH]c3)c2)c1 CHEMBL3704383 IC50 2.5 nM
c1ccc(Cn2nnc(-c3ccc4[nH]ncc4c3)c2C2CC2)cc1 CHEMBL1975418 pKi 2.512 nM
CN(C)C1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1969151 pKi 2.512 nM
O=C(NC(CO)c1ccccc1)c1ccc(-c2ccncc2)cc1 CHEMBL1974288 pKi 2.512 nM
COc1cc(C(=O)NCc2cccc(Cl)c2Cl)ccc1-c1cn[nH]c1 CHEMBL3915532 IC50 2.53 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)NC(CN)Cc1ccccc1 CHEMBL3956875 IC50 2.53 nM
COc1cc(C(=O)NCc2ccc(F)cc2Cl)ccc1-c1cn[nH]c1 CHEMBL3969934 IC50 2.54 nM
CCC(C)OC(=O)c1cccc(NC(=O)c2cccc(-c3cc(C(=O)Nc4ccncc4F)ccc3CN)c2)c1 CHEMBL3426632 IC50 2.6 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc(-c5cnco5)cc4)c3)cc2C1 CHEMBL3680723 IC50 2.6 nM
Cc1cc(-c2ccc(C(=O)NCc3cccc(C(=O)Nc4nc5c(s4)CN(C)CC5)c3)cc2)ccn1 CHEMBL3680776 IC50 2.6 nM
CN1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)c4ccc(-c5cnco5)cc4)c3)sc2C1 CHEMBL3700953 IC50 2.6 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)c4ccc(-n5ccnc5)cc4)c3)sc2C1 CHEMBL3700974 IC50 2.6 nM
O=C(Nc1nc2c(s1)C[C@@H](N1CCOCC1)CC2)c1cccc([C@H]2CCCN2C(=O)c2ccc(-c3ccncc3)cc2)c1 CHEMBL3704379 IC50 2.6 nM
O=C(Nc1nc2c(s1)C[C@@H](N1CCOCC1)CC2)c1cccc([C@H]2CCCN2C(=O)c2csc(-c3cccnc3)n2)c1 CHEMBL3704381 IC50 2.6 nM
COc1cc(C(=O)NCc2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3910168 IC50 2.6 nM
COC(=O)c1cccc(CNC(=O)c2ccc(-c3cn[nH]c3)c(C)c2)c1 CHEMBL3934418 IC50 2.61 nM
CCNC(=O)c1cccc(CNC(=O)c2ccc(-c3cn[nH]c3)c(C)c2)c1 CHEMBL3986370 IC50 2.61 nM
Nc1nonc1-n1nnc(C(=O)NCc2cccc(C(=O)Nc3nc4c(s3)C[C@@H](N3CCOCC3)CC4)c2)c1-c1ccccc1 CHEMBL3680780 IC50 2.65 nM
COc1cc(C(=O)NCc2ccccc2F)ccc1-c1cn[nH]c1 CHEMBL3966859 IC50 2.65 nM
COc1cc(C(=O)N[C@H](C)c2ccc(F)cc2)ccc1-c1cn[nH]c1 CHEMBL3901566 IC50 2.69 nM
NCc1ccc(C(=O)Nc2ccncc2F)cc1-c1cccc(C(=O)OCC2CC2)c1 CHEMBL2440730 IC50 2.7 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1cccc(C(F)(F)F)c1 CHEMBL3793203 Ki 2.7 nM
O=C(Nc1nc2c(s1)C[C@@H](N1CCOCC1)CC2)c1cccc([C@H]2CCCN2C(=O)c2ccc3[nH]c(=O)ccc3c2)c1 CHEMBL3704376 IC50 2.7 nM
Nc1nonc1-n1nnc(C(=O)N2CCC[C@@H]2c2cccc(C(=O)Nc3nc4c(s3)C[C@@H](N3CCOCC3)CC4)c2)c1-c1ccccc1 CHEMBL3704380 IC50 2.7 nM
COc1cc(C(=O)N[C@H](CO)[C@H](O)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4108938 IC50 2.72 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)N[C@H](C)c1ccc(F)cc1 CHEMBL4112558 IC50 2.77 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)N[C@H](CCO)c1ccccc1 CHEMBL4108559 IC50 2.78 nM
COc1ccc(C(=O)N[C@@H](c2cccc(C(=O)Nc3nc4c(s3)CN(C)CC4)c2)C2CC2)cc1Cl CHEMBL3700903 IC50 2.8 nM
Cc1nc(-c2ccncc2)sc1C(=O)N1CCC[C@@H]1c1cccc(C(=O)Nc2nc3c(s2)C[C@@H](N(C)C)CC3)c1 CHEMBL3700940 IC50 2.8 nM
COc1cc(C(=O)N[C@H](CNS(=O)(=O)C2CC2)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4107417 IC50 2.89 nM
COC(=O)c1cccc(-c2cc(C(=O)Nc3ccncc3)ccc2CN)c1 CHEMBL2440743 IC50 2.9 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cn5ccc(C(N)=O)cc5n4)c3)cc2C1 CHEMBL3680724 IC50 2.9 nM
N#Cc1cccc2c1CCN2C(=O)N1CCC[C@@H]1c1cccc(C(=O)Nc2nc3c(s2)C[C@@H](N2CCOCC2)CC3)c1 CHEMBL3700980 IC50 2.9 nM
CN1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)c4cn5ccc(C#N)cc5n4)c3)sc2C1 CHEMBL3704390 IC50 2.9 nM
COc1cc(C(=O)NCc2c(F)cccc2F)ccc1-c1cn[nH]c1 CHEMBL3896978 IC50 2.95 nM
COc1cc(C(=O)NCc2c(F)ccc(C)c2F)ccc1-c1cn[nH]c1 CHEMBL3943471 IC50 2.97 nM
COc1cccc(CN(C(=O)Nc2ccc(-c3cn[nH]c3)cc2)C(C)C)c1 CHEMBL2332064 pIC50 2.999 nM
CCN(Cc1cccc(OC)c1)C(=O)Nc1ccc(-c2cn[nH]c2)cc1OCCN(C)C CHEMBL3402462 pIC50 2.999 nM
Nc1cccc(CNC(=O)Nc2ccc(-c3cn[nH]c3)cc2)c1 CHEMBL3402444 pIC50 2.999 nM
O=C(NCc1cccc(F)c1)Nc1ccc(-c2cn[nH]c2)cc1 CHEMBL3402446 pIC50 2.999 nM
COc1cccc(CN(CCN2CCCC2)C(=O)Nc2ccc(-c3cn[nH]c3)cc2)c1 CHEMBL2332069 pIC50 2.999 nM
COc1cc(-c2cn[nH]c2)ccc1NC(=O)C1COc2ccccc2C1 CHEMBL480586 IC50 3.0 nM
CN(C)CCOc1cc(-c2cn[nH]c2)ccc1NC(=O)C1COc2ccccc2C1 CHEMBL474425 IC50 3.0 nM
COc1ccc2c(c1)CC(C(=O)Nc1ccc(-c3cn[nH]c3)cc1)CO2 CHEMBL475601 IC50 3.0 nM
COc1ccc2c(c1)CC(C(=O)Nc1ccc(-c3cn[nH]c3)c(OC)c1)CO2 CHEMBL519304 IC50 3.0 nM
COc1ccc2c(c1)CC(C(=O)Nc1ccc(-c3cn[nH]c3)cc1OC)CO2 CHEMBL482351 IC50 3.0 nM
COc1cc(-c2cn[nH]c2)ccc1NC(=O)C1COc2ccc(F)cc2C1 CHEMBL520103 IC50 3.0 nM
COc1cc(-c2cn[nH]c2)ccc1NC(=O)C1COc2ccc(Cl)cc2C1 CHEMBL519959 IC50 3.0 nM
COc1ccc2c(c1)C[C@H](C(=O)Nc1cc(F)c(-c3cn[nH]c3)cc1OCCN(C)C)NC2 CHEMBL1215454 IC50 3.0 nM
COc1ccc2c(c1)C[C@H](C(=O)Nc1ccc(-c3cn[nH]c3)cc1OC1CCN(C)CC1)NC2 CHEMBL1215306 IC50 3.0 nM
O=c1[nH]c(C2COc3ccc(F)cc3C2)nc2ccc(-c3cn[nH]c3)cc12 CHEMBL1684204 IC50 3.0 nM
COCCNC(=O)c1ccc2c(c1)CC(c1nc(SCCN(C)C)c3cc(-c4cn[nH]c4)ccc3n1)CO2 CHEMBL1684219 IC50 3.0 nM
CN(C)CCSc1nc(C2COc3ccc(C(=O)NCCN4CCOCC4)cc3C2)nc2ccc(-c3cn[nH]c3)cc12 CHEMBL1684220 IC50 3.0 nM
COc1cccc(CN(C)C(=O)c2cc3ccc(-c4cn[nH]c4)cc3[nH]2)c1 CHEMBL1922029 IC50 3.0 nM
COc1cccc(CNC(=O)c2[nH]c3cc(-c4cn[nH]c4)ccc3c2CN2CCOCC2)c1 CHEMBL1922139 IC50 3.0 nM
O=C(NCCc1cccs1)c1c[nH]c2cc(-c3cn[nH]c3)ccc12 CHEMBL1923177 IC50 3.0 nM
CN(C)CCOc1cc(-c2cn[nH]c2)ccc1NC(=O)C1COc2ccccc2O1 CHEMBL521179 IC50 3.0 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1cccc(CO)c1 CHEMBL3792689 Ki 3.0 nM
O=C(NCc1cccc(O)c1)c1ccc(-c2ccncc2)cc1 CHEMBL4536833 IC50 3.0 nM
COc1cccc([C@@H](CCN2CCCC2)NC(=O)c2ccc(-c3ccncc3)cc2)c1 CHEMBL4583341 IC50 3.0 nM
CN(C)c1ccc(C(=O)Nc2cccc(NC(=O)COc3ccc4c(=O)ccoc4c3)c2)cc1 CHEMBL4438748 IC50 3.0 nM
COc1ccc2c(c1)C[C@H](C(=O)Nc1ccc(-c3ccncc3)cc1OCCN(C)C)CO2 CHEMBL4552537 IC50 3.0 nM
CCNC(=O)c1cc(CNC(=O)c2ccc3c(c2)C(CC)Oc2cnccc2-3)ccc1F CHEMBL4759713 IC50 3.0 nM
COc1cccc(CN2CCOc3cc(-c4ccncc4)ccc3C2=O)c1 CHEMBL4877688 IC50 3.0 nM
COc1ccc(Cl)c([C@@H](C)NC(=O)N2CCN(c3ccncc3F)C[C@H]2C)c1 CHEMBL5180112 IC50 3.0 nM
COc1cc(F)cc([C@@H](C)NC(=O)N2CCN(c3ccncc3F)C[C@H]2C)c1 CHEMBL5208605 IC50 3.0 nM
COc1cc([C@@H](C)NC(=O)N2CCN(c3ccncc3F)C[C@H]2C)ccc1F CHEMBL5199904 IC50 3.0 nM
COc1cccc([C@@H](C)NC(=O)N2CCN(c3ccncc3F)C[C@H]2C)c1 CHEMBL5206259 IC50 3.0 nM
c1cc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)cs1 CHEMBL225166 IC50 3.0 nM
O=C(OCC1CCCO1)c1cccc(CN2CCCC(Nc3ccc4[nH]ncc4c3)C2)c1 CHEMBL5281208 IC50 3.0 nM
O=C1NCc2c1c1c3cc(O)ccc3[nH]c1c1[nH]c3ccc(O)cc3c21 CHEMBL5398049 IC50 3.0 nM
O=c1cc(-c2ccccc2)ccn1-c1cccc(CN[C@H]2CCC[C@H](Nc3ccc4[nH]ncc4c3)C2)c1 CHEMBL5420736 IC50 3.0 nM
COc1ccc(F)c(C(C)NC(=O)c2ccc(-c3cn[nH]c3)cc2OC)c1 CHEMBL3899661 IC50 3.05 nM
COC(=O)c1ccc(C(=O)Nc2cccc(-c3cc(C(=O)Nc4ccncc4F)ccc3CN)c2)cc1 CHEMBL3426731 IC50 3.1 nM
CN1CCc2nc(NC(=O)c3cccc(CNC(=O)N4CCc5c(C#N)cccc54)c3)sc2C1 CHEMBL3680743 IC50 3.1 nM
COc1ccc(C(=O)N[C@H](C)c2cccc(C(=O)Nc3nc4c(s3)CN(C)CC4)c2)cc1OC CHEMBL3700970 IC50 3.1 nM
CN1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)Nc4cccc(C#N)c4)c3)sc2C1 CHEMBL3700973 IC50 3.1 nM
O=C(Nc1ccc(-c2n[nH]c(=O)c3ccccc23)cc1)N1Cc2cccnc2C1 CHEMBL3901432 Ki 3.1 nM
NCC(NC(=O)c1ccc(-c2ccncc2)cc1)c1ccccc1 CHEMBL1990254 pKi 3.162 nM
O=c1c(NCc2ccc(Cl)cc2Cl)c(Nc2ccc3[nH]ncc3c2)c1=O CHEMBL1979554 pKi 3.162 nM
NC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1983589 pKi 3.162 nM
NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(-c3ccncc3)ccc2c1=O CHEMBL340384 pKi 3.162 nM
CC(C)C(=O)OCc1ccc(C(CN)C(=O)Nc2ccc3cnccc3c2)cc1 CHEMBL3794444 Ki 3.2 nM
O=C(Nc1nc2c(s1)C[C@@H](N1CCOCC1)CC2)c1cccc([C@H]2CCCN2C(=O)c2csc(-c3ccncc3)n2)c1 CHEMBL3704373 IC50 3.2 nM
C[C@@H](NC(=O)c1ccc2c(c1)OCc1cnccc1-2)c1ccccc1 CHEMBL4756660 IC50 3.2 nM
COc1cc(-c2cn[nH]c2)ccc1NC(=O)C1COc2ccccc2O1 CHEMBL485215 IC50 3.3 nM
CC[C@@H](C)OC(=O)c1ccc(F)c(NC(=O)c2cccc(-c3cc(C(=O)Nc4ccncc4F)ccc3CN)c2)c1 CHEMBL3426636 IC50 3.3 nM
NCc1ccc(C(=O)Nc2ccncc2F)cc1-c1cccc(C(=O)Nc2ccc(C(=O)O)cc2)c1 CHEMBL3426628 IC50 3.3 nM
Cc1cccc(C(CN)C(=O)Nc2ccc3cnccc3c2)c1 CHEMBL3794198 Ki 3.3 nM
COc1cc(NC(=O)Cc2ccccc2Cl)ccc1-c1cn[nH]c1 CHEMBL4756156 IC50 3.3 nM
COCCOc1cc(-c2cn[nH]c2)ccc1C(=O)N[C@H](C)c1cccc(OC)c1 CHEMBL4110456 IC50 3.37 nM
N#Cc1ccc(NC(=O)COc2cccc(C(=O)Nc3nc4c(s3)C[C@@H](N3CCOCC3)CC4)c2)cc1 CHEMBL3700911 IC50 3.4 nM
COc1cc(C(=O)NC(C)c2c(F)cccc2Cl)ccc1-c1cn[nH]c1 CHEMBL3926244 IC50 3.43 nM
NC[C@@H](NC(=O)c1ccc(-c2cn[nH]c2)c(OCCO)c1)c1ccccc1 CHEMBL4111527 IC50 3.45 nM
NCc1ccc(C(=O)Nc2ccncc2F)cc1-c1cccc(C(=O)Nc2cccc(C(=O)O)c2F)c1 CHEMBL3426646 IC50 3.5 nM
O=C(Nc1nc2c(s1)C[C@@H](N1CCOCC1)CC2)c1cccc([C@H]2CCCN2C(=O)c2ccc(-n3ccnc3)cc2)c1 CHEMBL3704374 IC50 3.5 nM
Cc1cc(C(=O)N[C@H](C)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4111337 IC50 3.51 nM
COc1cc(C(=O)NCc2c(F)cccc2Cl)ccc1-c1cn[nH]c1 CHEMBL3960608 IC50 3.59 nM
COCCOC(=O)c1cccc(-c2cc(C(=O)Nc3ccncc3)ccc2CN)c1 CHEMBL2440732 IC50 3.6 nM
COc1ccc(C(=O)N2CCC[C@@H]2c2cccc(C(=O)Nc3nc4c(s3)C[C@@H](N3CCOCC3)CC4)c2)cc1OC CHEMBL3700982 IC50 3.6 nM
Cc1nc(-c2ccncc2)sc1C(=O)N1CCC[C@@H]1c1cccc(C(=O)Nc2nc3c(s2)C[C@@H](N2CCOCC2)CC3)c1 CHEMBL3704377 IC50 3.6 nM
O=C(Nc1ccc(-c2n[nH]c(=O)c3ccccc23)cc1)N1Cc2ccccc2C1 CHEMBL3915867 Ki 3.6 nM
CC(N)c1ccc(C(=O)Nc2ccnc3[nH]ccc23)cc1 CHEMBL3185765 IC50 3.6 nM
CN1CCN(Cc2ccc3c(c2)CN(C(=O)Nc2ccc(-c4n[nH]c(=O)c5ccccc45)cc2)C3)CC1 CHEMBL3946294 Ki 3.61 nM
COc1cc(C(=O)N[C@@H](CO)c2c(F)cccc2F)ccc1-c1cn[nH]c1 CHEMBL3920393 IC50 3.69 nM
CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cn5cc(C(N)=O)ccc5n4)c3)sc2C1 CHEMBL3680806 IC50 3.7 nM
N#Cc1ccc(NC(=O)COc2cccc(C(=O)Nc3nc4c(s3)C[C@@H](N)CC4)c2)cc1 CHEMBL3700909 IC50 3.7 nM
Cc1cc(=O)n(-c2cccc(CN[C@H]3CCC[C@H](Nc4ccc5[nH]ncc5c4)C3)c2)cc1F CHEMBL5407146 IC50 3.7 nM
N=C(N)NCCC[C@@H](NC(=O)[C@@H](CCCNC(=N)N)NC(=O)CCCCCNC(=O)[C@@H](CCCCN)NC(=O)CCCCCNC(=O)c1cccc(-c2ccncc2)c1)C(N)=O CHEMBL1077370 Kd 3.8 nM
C[C@H]1CNCCCN1S(=O)(=O)c1cccc2cncc(F)c12 CHEMBL3426621 IC50 3.8 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cc5cc(C(N)=O)ccc5n4C)c3)cc2C1 CHEMBL3680747 IC50 3.8 nM
CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cc5cc(C#N)ccc5n4C)c3)sc2C1 CHEMBL3680763 IC50 3.8 nM
CC[C@@H](NC(=O)c1ccc(OC)c(Cl)c1)c1cccc(C(=O)Nc2nc3c(s2)CN(C)CC3)c1 CHEMBL3700912 IC50 3.8 nM
CN(C)[C@H]1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)c4ccc(-c5ccncc5)cc4)c3)sc2C1 CHEMBL3700963 IC50 3.8 nM
COc1ccc(C(=O)N[C@H](C)c2cccc(C(=O)Nc3nc4c(s3)CN(C)CC4)c2)cc1Cl CHEMBL3700964 IC50 3.9 nM
COc1cc(C(=O)NCc2cccc(OC(F)F)c2)ccc1-c1cn[nH]c1 CHEMBL3943648 IC50 3.94 nM
COC[C@@H](NC(=O)c1ccc(-c2cn[nH]c2)c(OC)c1)c1ccccc1 CHEMBL4112614 IC50 3.94 nM
Cc1cc(C(=O)N[C@H](CN(C)C)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4109081 IC50 3.94 nM
NCCC(C(=O)Nc1ccc2[nH]ncc2c1)c1ccc(Cl)c(Cl)c1 CHEMBL1998121 pKi 3.981 nM
CC(C)(CN)CNc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL1968930 pKi 3.981 nM
c1ccc(CNc2nc3ccc(-c4ccncc4)cc3s2)cc1 CHEMBL1983534 pKi 3.981 nM
c1ccc(CNc2cc(-c3c[nH]c4ncccc34)ncn2)cc1 CHEMBL2002346 pKi 3.981 nM
NC(Cc1c[nH]c2ccccc12)C(=O)Nc1cncc(C=Cc2ccncc2)c1 CHEMBL1983945 pKi 3.981 nM
COc1cc(C(=O)NCc2c(F)ccc(F)c2Cl)ccc1-c1cn[nH]c1 CHEMBL3948586 IC50 3.99 nM
COc1cccc(CN(CCCN2CCOCC2)C(=O)Nc2ccc(-c3cn[nH]c3)cc2)c1 CHEMBL2332072 pIC50 3.999 nM
COc1cccc(CN(CCCN2CCCCC2)C(=O)Nc2ccc(-c3cn[nH]c3)cc2)c1 CHEMBL2332074 pIC50 3.999 nM
COc1cc(NC(=O)C2COc3ccccc3C2)ccc1-c1cn[nH]c1 CHEMBL480585 IC50 4.0 nM
O=C(Nc1ccc(-c2cn[nH]c2)cc1F)C1COc2ccccc2C1 CHEMBL519101 IC50 4.0 nM
O=C(Nc1cc(F)c(-c2cn[nH]c2)c(F)c1)C1COc2ccccc2C1 CHEMBL480746 IC50 4.0 nM
O=C(Nc1ccc(-c2cn[nH]c2)cc1)C1COc2ccc(F)cc2C1 CHEMBL475612 IC50 4.0 nM
COc1cc(-c2cn[nH]c2)ccc1NC(=O)C1COc2ccc(C)cc2C1 CHEMBL519269 IC50 4.0 nM
NC(=O)c1ccc(NC(=O)NCc2cccc(C(=O)Nc3ccc4c(c3)CNCC4)c2)cc1 CHEMBL600852 IC50 4.0 nM
COc1cccc(C2CNCC2C(=O)Nc2cc3cc[nH]c(=O)c3cc2Cl)c1 CHEMBL1083748 IC50 4.0 nM
CCc1cccc(C2CNCC2C(=O)Nc2cc3cc[nH]c(=O)c3cc2Cl)c1 CHEMBL1084051 IC50 4.0 nM
O=C(Nc1cc2cc[nH]c(=O)c2cc1Cl)C1CNCC1c1cccc(C(F)(F)F)c1 CHEMBL1083276 IC50 4.0 nM
O=C(Nc1cc2cc[nH]c(=O)c2cc1Cl)C1CNCC1c1ccc(Br)cc1 CHEMBL1084653 IC50 4.0 nM
O=C(Nc1cc2cc[nH]c(=O)c2cc1Cl)[C@@H]1CNC[C@H]1c1ccc(Cl)cc1 CHEMBL1082821 IC50 4.0 nM
COc1ccc2c(c1)C[C@H](C(=O)Nc1ccc(-c3cn[nH]c3)cc1SCCC(=O)N(C)C)NC2 CHEMBL1215452 IC50 4.0 nM
COc1cccc(CN(C)C(=O)c2cc3ccc(-c4cn[nH]c4)nc3[nH]2)c1 CHEMBL1922042 IC50 4.0 nM
CCn1c(-c2nonc2N)nc2cnc(Oc3cccc(NC(=O)c4ccc(OCCN5CCOCC5)cc4)c3)cc21 CHEMBL220241 IC50 4.0 nM
C[N+]1(C)C[C@@H](c2ccccc2)[C@H](c2nc3ccc(-c4cn[nH]c4)cc3c(=O)[nH]2)C1 CHEMBL2333886 IC50 4.0 nM
COc1ccc(C[C@H](N)c2nc3ccc(-c4cn[nH]c4)cc3c(=O)[nH]2)cc1 CHEMBL2333909 IC50 4.0 nM
N[C@H](Cc1ccc(Cl)cc1)c1nc2ccc(-c3cn[nH]c3)cc2c(=O)[nH]1 CHEMBL2334294 IC50 4.0 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cccc(-c5cn[nH]c5)c4)c3)cc2C1 CHEMBL3680695 IC50 4.0 nM
CN1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)c4csc(-c5cccnc5)n4)c3)sc2C1 CHEMBL3700944 IC50 4.0 nM
C[C@@H](NC(=O)c1ccc(-c2cn[nH]c2)c(OC(F)F)c1)c1ccccc1 CHEMBL4108218 IC50 4.0 nM
COc1ccc(Cn2cnc3sc(-c4ccnc5[nH]ccc45)cc3c2=O)cc1OC CHEMBL4648698 IC50 4.0 nM
COc1cc(Cn2cnc3sc(-c4ccnc5[nH]ccc45)cc3c2=O)cc(OC)c1 CHEMBL4634539 IC50 4.0 nM
COc1cc(NC(=O)[C@H](N)c2ccccc2Cl)ccc1-c1cn[nH]c1 CHEMBL4780269 IC50 4.0 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3ccnc(F)c3)cc2)c1 CHEMBL4459800 IC50 4.0 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3ccncc3)nc2)c1 CHEMBL5181094 IC50 4.0 nM
COc1cccc(CNC(=O)c2nc3ccc(-c4cn[nH]c4)cc3[nH]2)c1 CHEMBL5269818 IC50 4.0 nM
COc1cc(C(=O)NCc2cccc(F)c2)ccc1-c1cn[nH]c1 CHEMBL3967386 IC50 4.01 nM
COC(=O)c1ccc(NC(=O)c2cccc(-c3cc(C(=O)Nc4ccncc4F)ccc3CN)c2)cc1 CHEMBL3426624 IC50 4.1 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cc5ccc(C#N)cc5n4C)c3)cc2C1 CHEMBL3680744 IC50 4.1 nM
CN1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)c4cc(-c5ccncc5)[nH]n4)c3)sc2C1 CHEMBL3700950 IC50 4.1 nM
O=C(Nc1ccc(-c2c[nH]c(=O)c3ccccc23)cc1)N1Cc2ccc(CN3CCOCC3)cc2C1 CHEMBL3933851 Ki 4.12 nM
Cc1ccc(C(=O)OCc2ccc(C(CN)C(=O)Nc3ccc4cnccc4c3)cc2)c(C)c1 CHEMBL3794389 Ki 4.2 nM
O=C(Nc1nc2c(s1)C[C@@H](N1CCOCC1)CC2)c1cccc([C@H]2CCCN2C(=O)c2cc(-c3ccncc3)[nH]n2)c1 CHEMBL3704382 IC50 4.2 nM
O=C(N[C@@H]1CNCC[C@H]1c1cc(F)c(F)c(F)c1)c1cc2c(s1)OCCn1ncc(Br)c1-2 CHEMBL5400934 IC50 4.2 nM
N#Cc1ccc2c(c1)CN(C(=O)Nc1ccc(-c3c[nH]c(=O)c4ccccc34)cc1)C2 CHEMBL3918406 Ki 4.24 nM
NCc1ccc(C(=O)Nc2ccncc2F)cc1-c1cccc(C(=O)OCC2CCC2)c1 CHEMBL2440756 IC50 4.3 nM
COc1cc(C(=O)NCc2cc(F)ccc2Cl)ccc1-c1cn[nH]c1 CHEMBL3908876 IC50 4.39 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)NCc1c(F)cccc1F CHEMBL3939886 IC50 4.39 nM
COc1cc(C(=O)NCc2ccc(F)c(C(=O)O)c2)ccc1-c1cn[nH]c1 CHEMBL3964232 IC50 4.41 nM
COc1cc(C(=O)N[C@H](CNC2CC2)c2c(F)cccc2F)ccc1-c1cn[nH]c1 CHEMBL4110459 IC50 4.53 nM
CN1CCC(OC(=O)Cc2ccc(NC(=O)c3cccc(-c4cc(C(=O)Nc5ccncc5F)ccc4CN)c3)cc2)CC1 CHEMBL3426729 IC50 4.6 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc(C5CSN=N5)cc4)c3)cc2C1 CHEMBL3680710 IC50 4.6 nM
COc1cc(C(=O)NCc2ccc(Br)cc2Cl)ccc1-c1cn[nH]c1 CHEMBL3906535 IC50 4.69 nM
COc1cccc([C@@H](C)NC(=O)c2ccc3c(c2)OC(C)c2cnccc2-3)c1 CHEMBL4778671 IC50 4.7 nM
COc1cc(C(=O)NC2(c3ccccc3Cl)CC2)ccc1-c1cn[nH]c1 CHEMBL3923391 IC50 4.73 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(OC(=O)c2cccnc2)cc1 CHEMBL3792612 Ki 4.8 nM
CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4csc(-c5cccnc5)n4)c3)sc2C1 CHEMBL3680699 IC50 4.8 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cnc(-c5cccnc5)s4)c3)cc2C1 CHEMBL3680799 IC50 4.8 nM
COc1cccc(CNC(=O)c2ccc(-c3cn[nH]c3)cc2OC)c1 CHEMBL3944065 IC50 4.81 nM
CCCCCOC(=O)c1cccc(-c2cc(C(=O)Nc3ccncc3)ccc2CN)c1 CHEMBL2440747 IC50 4.9 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc(-n5ccnc5)cc4)c3)cc2C1 CHEMBL3680717 IC50 4.9 nM
COc1cc(C(=O)NCc2ccc(Cl)cc2)ccc1-c1cn[nH]c1 CHEMBL3965421 IC50 4.93 nM
COc1cc(-c2cn[nH]c2)c(F)cc1NC(=O)C1COc2ccccc2C1 CHEMBL481731 IC50 5.0 nM
O=C(Nc1ccc(-c2cn[nH]c2)cc1)C1COc2ccc(Cl)cc2C1 CHEMBL475613 IC50 5.0 nM
CN(C)CCOc1cc(-c2cn[nH]c2)ccc1NC(=O)C1COc2ccc(Cl)cc2C1 CHEMBL481553 IC50 5.0 nM
Cc1cccc(C2CNCC2C(=O)Nc2cc3cc[nH]c(=O)c3cc2Cl)c1 CHEMBL1083749 IC50 5.0 nM
COc1cc(-c2cn[nH]c2)cc2c(=O)[nH]c(C3COc4ccc(C)cc4C3)nc12 CHEMBL1684226 IC50 5.0 nM
COc1cccc(CNC(=O)c2cn(-c3ccccc3)c3cc(-c4cn[nH]c4)ccc23)c1 CHEMBL1922125 IC50 5.0 nM
COc1cccc(CNC(=O)c2cc3ccc(-c4cn[nH]c4C)nc3[nH]2)c1 CHEMBL1923165 IC50 5.0 nM
COc1ccccc1CNC(=O)c1cc2ccc(-c3cn[nH]c3)nc2[nH]1 CHEMBL1923179 IC50 5.0 nM
COc1cccc(CN(CCN2CCCCC2)C(=O)Nc2ccc(-c3cn[nH]c3)cc2)c1 CHEMBL2332073 IC50 5.0 nM
COc1cccc(CN(CCCN2CCCC2)C(=O)Nc2ccc(-c3cn[nH]c3)cc2)c1 CHEMBL2332070 IC50 5.0 nM
COc1ccc([C@@H]2CN(C)C[C@H]2c2nc3ccc(-c4cn[nH]c4)cc3c(=O)[nH]2)cc1 CHEMBL2333887 IC50 5.0 nM
NCc1ccc(C(=O)Nc2ccncc2)cc1-c1cccc(C(=O)OCC2CCCC2)c1 CHEMBL2440753 IC50 5.0 nM
COc1cccc(CNC(=O)Nc2ccc(-c3ccncc3)cc2)c1 CHEMBL3402448 IC50 5.0 nM
CC(C)(C)c1cc(C(=O)Nc2cccc(NC(=O)COc3ccc4c(=O)ccoc4c3)c2)no1 CHEMBL4451007 IC50 5.0 nM
Cc1cc(C(=O)Nc2cccc(NC(=O)COc3ccc4c(=O)ccoc4c3)c2)no1 CHEMBL4562184 IC50 5.0 nM
Nc1cc(-c2cc3c(=O)n(Cc4cccc(F)c4)cnc3s2)ccn1 CHEMBL4649693 IC50 5.0 nM
COc1cc(NC(=O)[C@H](N)Cc2ccc(Cl)c(Cl)c2)ccc1-c1cn[nH]c1 CHEMBL4764401 IC50 5.0 nM
Cc1cncc2sc(NC(=O)C3CC3c3cc(C(=O)NCc4ncccn4)cs3)cc12 CHEMBL4743703 IC50 5.0 nM
C[C@@H]1CN(c2ccncc2F)CCN1C(=O)N[C@H](C)c1cccc2nccn12 CHEMBL5186165 IC50 5.0 nM
Nc1ccn(-c2ccc(CN3CCCC(Nc4ccc5[nH]ncc5c4)C3)cc2)c(=O)n1 CHEMBL5421321 IC50 5.0 nM
COc1cccc(C(CN)NC(=O)c2ccc(-c3ccncc3)cc2)c1 CHEMBL1976240 pKi 5.012 nM
COCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1964340 pKi 5.012 nM
CN(C)c1cccc2c(S(=O)(=O)N(CCN)c3cncc(-c4ccc5cnccc5c4)c3)cccc12 CHEMBL1967544 pKi 5.012 nM
COc1ccc(F)c(C(C)NC(=O)c2ccc(-c3c[nH]nc3C)cc2OC)c1 CHEMBL3950642 IC50 5.09 nM
CCCOC(=O)c1cccc(-c2cc(C(=O)Nc3ccncc3F)ccc2CN)c1 CHEMBL2440750 IC50 5.1 nM
N#Cc1ccc(NC(=O)OCc2cccc(C(=O)Nc3nc4c(s3)C[C@@H](NCCC(F)(F)F)CC4)c2)cc1 CHEMBL3704388 IC50 5.1 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)NC(C)c1c(F)cccc1F CHEMBL3894616 IC50 5.13 nM
N#CCCN[C@H]1CCc2nc(NC(=O)c3cccc(COC(=O)Nc4ccc(C#N)cc4)c3)sc2C1 CHEMBL3704385 IC50 5.2 nM
COc1cc(C(=O)NCc2cc(F)ccc2F)ccc1-c1cn[nH]c1 CHEMBL3921599 IC50 5.2 nM
O=C1N(c2ccccc2)CCN1c1ccc(-c2n[nH]c(=O)c3ccccc23)cc1 CHEMBL5275907 IC50 5.2 nM
O=C(Nc1ccc(-c2c[nH]c(=O)c3ccccc23)cc1)N1Cc2ccccc2C1 CHEMBL3943820 Ki 5.26 nM
COc1cc(C(=O)NCc2c(F)ccc(OC)c2F)ccc1-c1cn[nH]c1 CHEMBL3926788 IC50 5.35 nM
CN1CCc2nc(NC(=O)c3cccc(C4CCCN4C(=O)Nc4ccc(C(N)=O)cc4)c3)sc2C1 CHEMBL3700955 IC50 5.4 nM
CC(O)c1cc(C(=O)N[C@H](C)c2ccccc2F)ccc1-c1cn[nH]c1 CHEMBL4113260 IC50 5.43 nM
CCCCOC(=O)c1cccc(-c2cc(C(=O)Nc3ccncc3)ccc2CN)c1 CHEMBL2440746 IC50 5.5 nM
CC[C@H](C)OC(=O)c1ccc(F)c(NC(=O)c2cccc(-c3cc(C(=O)Nc4ccncc4F)ccc3CN)c2)c1 CHEMBL3426635 IC50 5.5 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(O)c(O)c1 CHEMBL3794254 Ki 5.5 nM
C[C@@H](NC(=O)Nc1cccc(C#N)c1)c1cccc(C(=O)Nc2nc3c(s2)CN(C)CC3)c1 CHEMBL3700957 IC50 5.5 nM
CN(C)CCSc1cc(-c2cn[nH]c2)ccc1NC(=O)NCc1ccccc1 CHEMBL3402473 IC50 5.6 nM
COc1cc(NC(=O)[C@H](N)CCc2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4741358 IC50 5.6 nM
O=C1C(Nc2cccc(OC(F)(F)F)c2)CCN1c1ccc(-c2n[nH]c(=O)c3ccccc23)cc1 CHEMBL5287054 IC50 5.6 nM
COc1cc(C(=O)NCc2ccccc2O)ccc1-c1cn[nH]c1 CHEMBL3986384 IC50 5.62 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)NC(CO)c1ccccc1F CHEMBL3890689 IC50 5.62 nM
COC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]cc(F)c34)CC2)c1 CHEMBL3613621 IC50 5.7 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc(-n5cncn5)cc4)c3)cc2C1 CHEMBL3680794 IC50 5.7 nM
CC[C@@H](NC(=O)Nc1cccc(C#N)c1)c1cccc(C(=O)Nc2nc3c(s2)CN(C)CC3)c1 CHEMBL3700908 IC50 5.7 nM
COc1cc(C(=O)N[C@H](CO)Cc2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3896691 IC50 5.7 nM
O=C1NCc2c1c1c3cc(O)ccc3[nH]c1c1[nH]c3ccccc3c21 CHEMBL4294912 IC50 5.7 nM
CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4csc(-c5ccncc5)n4)c3)sc2C1 CHEMBL3680703 IC50 5.8 nM
N#Cc1cccc(NC(=O)N2CCC[C@@H]2c2cccc(C(=O)Nc3ccc(CCN4CCOCC4)cc3)c2)c1 CHEMBL3700914 IC50 5.8 nM
COc1ccc(C(=O)N2CCC[C@@H]2c2cccc(C(=O)Nc3nc4c(s3)C[C@@H](N3CCOCC3)CC4)c2)cc1Cl CHEMBL3700983 IC50 5.8 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cn5cc(C(N)=O)ccc5n4)c3)cc2C1 CHEMBL3680702 IC50 5.9 nM
Cc1c(C(=O)NCc2cccc(C(=O)Nc3ccc4c(c3)CN(C)CC4)c2)nnn1-c1nonc1N CHEMBL3680764 IC50 5.9 nM
CCN(Cc1cccc(OC)c1)C(=O)Nc1ccc(-c2cn[nH]c2)cc1N(C)CCN(C)C CHEMBL3402464 pIC50 5.998 nM
Nc1nccc(-c2ccc3nc(C4COc5ccc(F)cc5C4)[nH]c3c2)n1 CHEMBL518825 IC50 6.0 nM
COC(=O)c1ccc2c(c1)CC(c1nc3ccc(-c4ccnc(N)n4)cc3[nH]1)CO2 CHEMBL462194 IC50 6.0 nM
O=C(Nc1cc2cc[nH]c(=O)c2cc1Cl)C1CNCCC1c1ccccc1 CHEMBL1084324 IC50 6.0 nM
O=C(Nc1cc2cc[nH]c(=O)c2cc1Cl)C1CNCC1c1ccccc1 CHEMBL1084597 IC50 6.0 nM
CC(C)c1cccc(C2CNCC2C(=O)Nc2cc3cc[nH]c(=O)c3cc2Cl)c1 CHEMBL1085773 IC50 6.0 nM
O=C(Nc1cc2cc[nH]c(=O)c2cc1Cl)C1CNCC1c1ccc(Cl)cc1 CHEMBL1082819 IC50 6.0 nM
CN(C)CCOc1cc(-c2cn[nH]c2)c(F)cc1NC(=O)[C@H]1Cc2ccccc2CN1 CHEMBL1215524 IC50 6.0 nM
COc1ccc2c(c1)C[C@H](C(=O)Nc1ccc(-c3cn[nH]c3)cc1OCCN1CCCC1)NC2 CHEMBL1215305 IC50 6.0 nM
c1ccc(-c2c(-c3ccc4[nH]ncc4c3)nc3ncccn23)cc1 CHEMBL1682541 Ki 6.0 nM
Cc1ccc2c(c1)CC(c1nc3ccc(-c4cn[nH]c4)cc3c(=O)[nH]1)CO2 CHEMBL1684203 IC50 6.0 nM
COc1ccc2c(c1)CC(c1nc(SCCN(C)C)c3cc(-c4cn[nH]c4)ccc3n1)CO2 CHEMBL1684214 IC50 6.0 nM
CN(C)CCSc1nc(C2COc3ccc(C(=O)NC4CC4)cc3C2)nc2ccc(-c3cn[nH]c3)cc12 CHEMBL1684218 IC50 6.0 nM
COc1cccc(CN(C(=O)c2c[nH]c3nc(-c4cn[nH]c4)ccc23)C2CC2)c1 CHEMBL1922133 IC50 6.0 nM
CCn1c(-c2nonc2N)nc2cncc(C(=O)N3CC[C@H](N)C3)c21 CHEMBL1956071 IC50 6.0 nM
NCCC(=O)NC(c1ccc(Cl)cc1)c1nc2ccc(-c3cn[nH]c3)cc2c(=O)[nH]1 CHEMBL2333883 IC50 6.0 nM
N[C@@H](Cc1ccc(Cl)cc1)c1nc2ccc(-c3cn[nH]c3)cc2c(=O)[nH]1 CHEMBL2334293 IC50 6.0 nM
Nc1nccc(-c2ccc3nc([C@@H]4CNC[C@H]4c4ccccc4)[nH]c(=O)c3c2)n1 CHEMBL2334290 IC50 6.0 nM
O=C(NCc1cccc(O)c1)Nc1nc(-c2ccncc2)cs1 CHEMBL3218011 IC50 6.0 nM
Cc1nnnn1-c1ccc(C(=O)NCc2cccc(C(=O)Nc3nc4c(s3)CN(C)CC4)c2)cc1 CHEMBL3680697 IC50 6.0 nM
N#Cc1cccc(NC(=O)N2CCC[C@@H]2c2cccc(C(=O)Nc3ccc(CCN4CCCC4)cc3)c2)c1 CHEMBL3700915 IC50 6.0 nM
CN1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)c4nnn(-c5nonc5N)c4-c4ccccc4)c3)sc2C1 CHEMBL3700923 IC50 6.0 nM
COc1cccc([C@@H](CCO)NC(=O)c2ccc(-c3ccncc3)cc2)c1 CHEMBL4469316 IC50 6.0 nM
COc1cccc(Cn2cnc3sc(-c4ccncc4)cc3c2=O)c1 CHEMBL4643315 IC50 6.0 nM
O=C(Nc1nc2ccncc2s1)[C@@H]1C[C@H]1c1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL4763003 IC50 6.0 nM
O=C(Nc1ccc2cnccc2n1)[C@@H]1C[C@H]1c1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL4783299 IC50 6.0 nM
COc1cccc([C@@H](C)NC(=O)N2CCN(c3ccnc(F)c3)C[C@H]2C)c1 CHEMBL5188032 IC50 6.0 nM
Cc1nnnn1-c1ccc(C(=O)NCc2cccc(C(=O)NC3=NC4CCN(C)CC4S3)c2)cc1 CHEMBL5279379 IC50 6.0 nM
COc1cccc(CN(C(=O)c2n[nH]c3cc(-c4cn[nH]c4)ccc23)C2CC2)c1 CHEMBL5267373 IC50 6.0 nM
CN1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)c4csc(-c5ccncc5)n4)c3)sc2C1 CHEMBL3700948 IC50 6.1 nM
N#Cc1ccc(NC(=O)COc2cccc(C(=O)Nc3nc4c(s3)CC(N3CCN(C5CC5)CC3)CC4)c2)cc1 CHEMBL3704393 IC50 6.1 nM
CCc1ccn(-c2cccc(CN[C@H]3CCC[C@@H](Nc4ccc5[nH]ncc5c4)C3)c2)c(=O)c1C CHEMBL5414693 IC50 6.1 nM
COc1ccc2c(c1)CN(C(=O)Nc1ccc(-c3c[nH]c(=O)c4ccccc34)cc1)C2 CHEMBL3909474 Ki 6.14 nM
NCc1ccc(C(=O)Nc2ccncc2F)cc1-c1cccc(C(=O)Oc2ccccc2)c1 CHEMBL2440752 IC50 6.2 nM
CCCC[C@@H](NC(=O)c1ccc(OC)c(OC)c1)c1cccc(C(=O)Nc2nc3c(s2)CN(C)CC3)c1 CHEMBL3700971 IC50 6.2 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)NCc1ccccc1Cl CHEMBL3914530 IC50 6.2 nM
COc1cccc(C(C)NC(=O)c2ccc3c(c2)OCc2cnccc2-3)n1 CHEMBL4749682 IC50 6.2 nM
COc1cccc(CNC(=O)c2ccc3c(c2)OCc2cnccc2-3)c1 CHEMBL4797055 IC50 6.3 nM
O=C1C(Oc2cccc(OC(F)(F)F)c2)CCN1c1ccc(-c2n[nH]c(=O)c3ccccc23)cc1 CHEMBL5271236 IC50 6.3 nM
CC(NC(=O)c1ccc(-c2ccncc2)cc1)c1ccccc1 CHEMBL1999428 pKi 6.31 nM
c1cnc2[nH]cc(-c3ccnc(NCC4CCCCC4)n3)c2c1 CHEMBL213207 pKi 6.31 nM
COc1cc(C(=O)NCc2cccc(NS(C)(=O)=O)c2)ccc1-c1cn[nH]c1 CHEMBL3965403 IC50 6.33 nM
N=C(N)NCCC[C@@H](NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)CNCC(=O)NCCNS(=O)(=O)c1cccc2cnccc12)C(N)=O CHEMBL2023840 Kd 6.4 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)NCc1c(F)cccc1Cl CHEMBL3978005 IC50 6.48 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cccc(-c5cnco5)c4)c3)cc2C1 CHEMBL3680798 IC50 6.5 nM
CN1CCN(C2CCc3nc(NC(=O)c4cccc(OCC(=O)Nc5ccc(C#N)cc5)c4)sc3C2)CC1 CHEMBL3704395 IC50 6.5 nM
O=C(Nc1ccc(-c2n[nH]c(=O)c3c2CCCC3)cc1)N1Cc2ccc(Cl)cc2C1 CHEMBL5273210 Ki 6.5 nM
O=C(Nc1ccc(-c2c[nH]c(=O)c3ccccc23)cc1)N1Cc2ccc(Cl)cc2C1 CHEMBL3981575 Ki 6.51 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)NC(c1ccccc1F)C(C)(C)O CHEMBL3965594 IC50 6.52 nM
NCc1ccc(C(=O)Nc2ccncc2F)cc1-c1cccc(C(=O)Nc2cccc(C(=O)O)c2)c1 CHEMBL3426626 IC50 6.6 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc(-c5cc[nH]n5)cc4)c3)cc2C1 CHEMBL3680783 IC50 6.6 nM
COc1cc(C(=O)NCCc2ccccc2Cl)ccc1-c1cn[nH]c1 CHEMBL3920786 IC50 6.6 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3cn[nH]c3)c(C#N)c2)c1 CHEMBL4740106 IC50 6.7 nM
COc1cccc(C(C)NC(=O)c2ccc(-c3cn[nH]c3)c(C#N)c2)c1 CHEMBL3937334 IC50 6.74 nM
COc1cc(C(=O)NC(C)c2cccc(O)n2)ccc1-c1cn[nH]c1 CHEMBL3965517 IC50 6.76 nM
NCC(C(=O)Nc1ccc2cnccc2c1)c1ccc(OC(=O)c2ccccc2)cc1 CHEMBL3794435 Ki 6.8 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)N4CCc5c(C#N)cccc54)c3)cc2C1 CHEMBL3680802 IC50 6.9 nM
CN1CCc2nc(NC(=O)c3cccc([C@H]4CCCN4C(=O)N4CCc5c(C#N)cccc54)c3)sc2C1 CHEMBL3700936 IC50 6.9 nM
O=C(N[C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1)c1cc2c(s1)CCCn1ncc(Cl)c1-2 CHEMBL5412156 IC50 6.9 nM
O=C(N[C@H](CO)c1ccccc1)c1ccc(-c2cn[nH]c2)c(OC(F)F)c1 CHEMBL4107796 IC50 6.94 nM
COc1cc(NC(=O)C2COc3ccc(F)cc3C2)ccc1-c1cn[nH]c1 CHEMBL482337 IC50 7.0 nM
CN(C)CCNC(=O)c1ccc2c(c1)CC(c1nc3ccc(-c4cn[nH]c4)cc3s1)CO2 CHEMBL1079920 IC50 7.0 nM
O=C(Nc1cc2cc[nH]c(=O)c2cc1Cl)C1CNCC1c1cccc(OC(F)(F)F)c1 CHEMBL1084800 IC50 7.0 nM
CN(C)CCOc1cc(-c2cn[nH]c2)ccc1NC(=O)[C@H]1Cc2cc(Cl)ccc2CN1 CHEMBL1215169 IC50 7.0 nM
CN(C)CCOc1cc(-c2cn[nH]c2)ccc1NC(=O)[C@@H]1Cc2ccccc2CN1 CHEMBL1215093 IC50 7.0 nM
CN(C)CCOc1cc(-c2cn[nH]c2)ccc1NC(=O)[C@H]1Cc2ccccc2CN1 CHEMBL1215092 IC50 7.0 nM
COc1cccc(CNC(=O)c2c[nH]c3nc(-c4ccncc4)ccc23)c1 CHEMBL1923168 IC50 7.0 nM
O=C(Nc1ccc(-c2cn[nH]c2)cc1)OCc1ccccc1 CHEMBL2332080 IC50 7.0 nM
N[C@H](Cc1ccc(F)c(F)c1)c1nc2ccc(-c3cn[nH]c3)cc2c(=O)[nH]1 CHEMBL2333912 IC50 7.0 nM
COc1cc(-c2cn[nH]c2)cc2c(=O)[nH]c([C@H](N)Cc3cccc(F)c3)nc12 CHEMBL2333908 IC50 7.0 nM
Cc1n[nH]cc1-c1ccc2nc([C@@H]3CNC[C@H]3c3ccccc3)[nH]c(=O)c2c1 CHEMBL2334291 IC50 7.0 nM
COc1ccc2c(c1)C[C@@H](C(=O)Nc1ccc(-c3cn[nH]c3)cc1OCCN(C)C)CO2 CHEMBL3221808 IC50 7.0 nM
CC(C)OC(=O)c1cccc(NC(=O)c2cccc(-c3cc(C(=O)Nc4ccncc4F)ccc3CN)c2)c1 CHEMBL3426630 IC50 7.0 nM
COc1cc(C(=O)NCCc2cccc(O)c2)ccc1-c1cn[nH]c1 CHEMBL3976118 IC50 7.0 nM
COc1ccc(C(=O)Nc2cccc(NC(=O)COc3ccc4c(=O)ccoc4c3)c2)cc1 CHEMBL4446390 IC50 7.0 nM
CN(C)CCOc1cc(-c2ccncc2)ccc1NC(=O)C1COc2ccc(F)cc2C1 CHEMBL4483646 IC50 7.0 nM
CN(C)CCOc1cc(-c2ccncc2)ccc1NC(=O)C1COc2ccccc2C1 CHEMBL4521642 IC50 7.0 nM
O=c1c2cc(-c3ccnc4[nH]ccc34)sc2ncn1Cc1cccc(C(F)(F)F)c1 CHEMBL4648713 IC50 7.0 nM
COc1cc(NC(=O)[C@H](O)c2ccccc2Cl)ccc1-c1cn[nH]c1 CHEMBL4784425 IC50 7.0 nM
COc1cc(NC(=O)Cc2ccccc2Cl)ccc1-c1cnco1 CHEMBL4799221 IC50 7.0 nM
O=C(Nc1ccc2cnccc2n1)C1CC1c1ccccc1 CHEMBL4776650 IC50 7.0 nM
COc1cccc([C@@H](C)NC(=O)N2CCN(c3ccncc3F)CC2)c1 CHEMBL5183751 IC50 7.0 nM
COc1ccc(F)c([C@@H](C)NC(=O)N2CCN(c3ccncc3F)C[C@H]2C)c1 CHEMBL5169406 IC50 7.0 nM
O=C(Cc1ccc(-c2n[nH]c(=O)c3ccccc23)cc1)N1CCc2ccccc21 CHEMBL5268152 IC50 7.0 nM
O=C1NC(=O)c2c1c1c3cc(O)ccc3[nH]c1c1[nH]c3ccc(O)cc3c21 CHEMBL5427567 IC50 7.0 nM
COC(=O)c1ccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]cc(C)c34)CC2)cc1 CHEMBL3613605 IC50 7.2 nM
COCCN(C)C1CCc2nc(NC(=O)c3cccc(OCC(=O)Nc4ccc(C#N)cc4)c3)sc2C1 CHEMBL3704397 IC50 7.2 nM
N[C@H]1CC[C@@H](C(=O)Nc2cc3cc[nH]c(=O)c3cc2Cl)C1 CHEMBL1222573 IC50 7.3 nM
O=C(NCc1ccccc1)c1cccc(NCc2nc(-c3ccncc3)c[nH]2)c1 CHEMBL4067877 IC50 7.3 nM
Cc1nc2ccc(NC3CCN(c4ccc(-c5n[nH]c(=O)c6ccccc56)cc4)C3=O)cc2s1 CHEMBL5286854 IC50 7.4 nM
C[C@@H](NC(=O)c1ccc(-c2cn[nH]c2)c(OC(F)F)c1)c1ccc(F)cc1 CHEMBL4114240 IC50 7.49 nM
N[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc(-c5csnn5)cc4)c3)sc2C1 CHEMBL3680705 IC50 7.6 nM
O=C(N[C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1)c1ccc2c(c1)OCCn1nccc1-2 CHEMBL5422811 IC50 7.6 nM
COc1cc(C(=O)NCc2cc(F)cc(F)c2F)ccc1-c1cn[nH]c1 CHEMBL3973474 IC50 7.66 nM
C[C@@H](NC(=O)c1ccc(-c2cn[nH]c2)c(O)c1)c1ccc(F)cc1 CHEMBL4113669 IC50 7.68 nM
CC(O)c1cc(C(=O)N[C@H](C)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4112045 IC50 7.73 nM
COC(=O)c1cccc(-c2cc(C(=O)Nc3ccncc3F)ccc2CN)c1 CHEMBL2440749 IC50 7.8 nM
COc1ccc(C(=O)N2CCC[C@@H]2c2cccc(C(=O)Nc3nc4c(s3)C[C@@H](N3CCOCC3)CC4)c2)cc1C CHEMBL3704370 IC50 7.8 nM
COc1nc(N[C@H]2CC[C@H](N)CC2)c(F)cc1C(N)=O CHEMBL4554795 IC50 7.8 nM
O=C(N[C@@H]1CNCC[C@H]1c1cccc(F)c1)c1cc2c(s1)CCCn1ncc(Cl)c1-2 CHEMBL5407182 IC50 7.8 nM
COC(=O)COc1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]cc(C)c34)CC2)c1 CHEMBL3613603 IC50 7.9 nM
C[C@H](O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)ccc1-c1cn[nH]c1 CHEMBL4107581 IC50 7.9 nM
Cc1cncc2cccc(S(=O)(=O)N3CCCNCC3C)c12 CHEMBL1082440 pKi 7.943 nM
Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1987448 pKi 7.943 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL1970903 pKi 7.943 nM
CN(C)CC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1982271 pKi 7.943 nM
COCC(C)Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1998068 pKi 7.943 nM
CNCC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1996980 pKi 7.943 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(CN)Cc4ccccc4)c3)cc12 CHEMBL2000271 pKi 7.943 nM
COc1cc(C(=O)NCc2ccc(F)c(F)c2)ccc1-c1cn[nH]c1 CHEMBL3969590 IC50 7.96 nM
COc1cc(C(=O)NCc2cccc3[nH]ncc23)ccc1-c1cn[nH]c1 CHEMBL3936240 IC50 7.99 nM
COc1cccc(CN(C)C(=O)Nc2ccc(-c3cn[nH]c3)cc2N(C)CCN(C)C)c1 CHEMBL3402461 pIC50 7.998 nM
COc1cc(NC(=O)C2COc3ccccc3C2)c(F)cc1-c1cn[nH]c1 CHEMBL514172 IC50 8.0 nM
Nc1nccc(-c2ccc3nc(C4COc5ccccc5C4)[nH]c3c2)n1 CHEMBL454654 IC50 8.0 nM
O=C(Nc1cc2cc[nH]c(=O)c2cc1Cl)C1CNCC1c1ccc(Cl)cc1Cl CHEMBL1083799 IC50 8.0 nM
O=C(Nc1cc2cc[nH]c(=O)c2cc1Cl)C1CNCC1c1cccnc1 CHEMBL1084104 IC50 8.0 nM
COc1cccc(CN(C(=O)c2cc3ccc(-c4cn[nH]c4)nc3[nH]2)C2CC2)c1 CHEMBL1922043 IC50 8.0 nM
COc1cccc(CNC(=O)c2cn(CCN3CCCC3)c3nc(-c4cn[nH]c4)ccc23)c1 CHEMBL1922137 IC50 8.0 nM
COc1cccc(CNC(=O)c2[nH]c3nc(-c4cn[nH]c4)ccc3c2CN2CCN(C)CC2)c1 CHEMBL1922142 IC50 8.0 nM
O=C(NCc1ccc(F)c(F)c1)c1c[nH]c2cc(-c3cn[nH]c3)ccc12 CHEMBL1923172 IC50 8.0 nM
COc1cc(-c2cn[nH]c2)cc2c(=O)[nH]c(C(N)c3cccc(Cl)c3)nc12 CHEMBL2333896 IC50 8.0 nM
COc1cc(-c2cn[nH]c2)cc2c(=O)[nH]c([C@@H](N)Cc3cccc(F)c3)nc12 CHEMBL2333907 IC50 8.0 nM
N[C@H](Cc1ccc(F)cc1)c1nc2ccc(-c3cn[nH]c3)cc2c(=O)[nH]1 CHEMBL2333906 IC50 8.0 nM
CC(C)N(Cc1ccccc1)C(=O)Nc1ccc(-c2cn[nH]c2)cc1 CHEMBL3402475 IC50 8.0 nM
O=C(N[C@H](CCN1CCCC1)c1ccccc1)c1ccc(-c2ccncc2)cc1 CHEMBL4459077 IC50 8.0 nM
COc1cc(NC(=O)[C@H](N)Cc2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4783577 IC50 8.0 nM
CCC(O)CNCc1ccnc2ccc(OC)cc12 CHEMBL4634858 IC50 8.02 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cc5cc(C#N)ccc5n4C)c3)cc2C1 CHEMBL3680745 IC50 8.1 nM
COc1cc(C(=O)NCc2cccc(C#N)c2)ccc1-c1cn[nH]c1 CHEMBL3914478 IC50 8.24 nM
COc1cc(C(=O)NCc2cc(F)c(F)c(F)c2)ccc1-c1cn[nH]c1 CHEMBL3953239 IC50 8.26 nM
C[C@@H](N)[C@H]1CC[C@H](C(=O)Nc2ccncc2)CC1 CHEMBL559147 IC50 8.3 nM
COCSC(C)CCSCCO CHEMBL4635281 IC50 8.4 nM
CN(C)CCN(C)c1cc(-c2cn[nH]c2)ccc1NC(=O)NCc1ccccc1 CHEMBL3402474 IC50 8.5 nM
COc1cc(C(=O)N[C@@H]2C[C@H]2c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL3965294 IC50 8.52 nM
NCc1ccc(C(=O)Nc2ccncc2F)cc1-c1cccc(C(=O)OC2CCCOC2)c1 CHEMBL2440736 IC50 8.7 nM
CN1CCc2nc(NC(=O)c3cccc(C4CCCN4C(=O)Nc4cccc(C#N)c4)c3)sc2C1 CHEMBL3700945 IC50 8.8 nM
COc1cccc([C@@H](C)NC(=O)c2ccc(-c3cn[nH]c3)cc2F)c1 CHEMBL4110256 IC50 8.87 nM
COC(=O)c1cccc(NC(=O)C2(CN(C)C)CCN(c3ncnc4[nH]cc(C)c34)CC2)c1 CHEMBL3613600 IC50 8.9 nM
COc1ccc(C(=O)N[C@H](C)c2cccc(C(=O)Nc3ccc4c(c3)CN(C)CC4)c2)cc1OC CHEMBL3704384 IC50 8.9 nM
COc1cc(C(=O)NC(C)c2ccccc2Cl)ccc1-c1cn[nH]c1 CHEMBL3984075 IC50 8.99 nM
Cc1[nH]ncc1-c1ccc2nc(C3COc4ccccc4C3)[nH]c2c1 CHEMBL453635 IC50 9.0 nM
Cc1[nH]ncc1-c1ccc2nc(C3COc4ccccc4C3)oc2c1 CHEMBL508975 IC50 9.0 nM
Nc1nccc(-c2ccc3nc(C4COc5ccccc5C4)sc3c2)n1 CHEMBL1079782 IC50 9.0 nM
O=C(Nc1cc2cc[nH]c(=O)c2cc1Cl)C1CNCC1c1ccc(F)cc1 CHEMBL1084110 IC50 9.0 nM
CCN1Cc2ccc(OC)cc2C[C@@H]1C(=O)Nc1cc(F)c(-c2cn[nH]c2)cc1OCCN(C)C CHEMBL1215594 IC50 9.0 nM
COc1cccc(CN(C)C(=O)c2cn(CCN(C)C)c3cc(-c4cn[nH]c4)ccc23)c1 CHEMBL1922130 IC50 9.0 nM
COc1cccc(CNC(=O)c2[nH]c3cc(-c4cn[nH]c4)ccc3c2CN(C)C)c1 CHEMBL1922138 IC50 9.0 nM
COc1ccccc1CNC(=O)c1c[nH]c2cc(-c3cn[nH]c3)ccc12 CHEMBL1923169 IC50 9.0 nM
COc1cc(-c2cn[nH]c2)cc2c(=O)[nH]c(C(N)c3ccc(Cl)cc3)nc12 CHEMBL2333895 IC50 9.0 nM
N[C@@H](Cc1ccc(F)cc1)c1nc2ccc(-c3cn[nH]c3)cc2c(=O)[nH]1 CHEMBL2333905 IC50 9.0 nM
COc1cccc([C@@H](C)NC(=O)Nc2nc(-c3ccncc3)cs2)c1 CHEMBL3218282 IC50 9.0 nM
Nc1ncnc2c1c(-c1cccc(O)c1)cn2[C@H]1C[C@@H](CN2CCC2)C1 CHEMBL3787112 IC50 9.0 nM
COc1ccc(C(=O)N[C@H](C)c2cccc(C(=O)Nc3nc4c(s3)CN(C)CC4)c2)cc1C CHEMBL3700967 IC50 9.0 nM
CCOc1ccc(C(=O)Nc2cccc(NC(=O)COc3ccc4c(=O)ccoc4c3)c2)cc1 CHEMBL4476505 IC50 9.0 nM
COc1ccc2c(c1)CC(C(=O)Nc1ccc(-c3ccncc3)cc1OCCN(C)C)CO2 CHEMBL4588109 IC50 9.0 nM
COC(=O)c1cccc(CN2CCOc3cc(-c4ccncc4)ccc3C2=O)c1 CHEMBL4876591 IC50 9.0 nM
COc1cccc([C@@H](C)NC(=O)N2CC[C@H](c3ccncc3)C[C@H]2C)c1 CHEMBL5200987 IC50 9.0 nM
O=C(Cc1ccccc1Cl)Nc1ccc(-c2cn[nH]c2)cc1OCCN1CCCC1 CHEMBL5281033 IC50 9.0 nM
COC(=O)c1ccc(N(C)C(C(=O)c2ccccc2)c2ccccc2)cc1 CHEMBL4633684 IC50 9.01 nM
COc1cc(C(=O)N[C@H](C)c2ccc3ccccc3c2)ccc1-c1cn[nH]c1 CHEMBL3916608 IC50 9.18 nM
COc1cc(C(=O)NC(C)c2cc(F)cc(F)c2)ccc1-c1cn[nH]c1 CHEMBL3934001 IC50 9.29 nM
O=C(Nc1ccc(-c2n[nH]c(=O)c3cccc(C(F)(F)F)c23)cc1)N1Cc2ccc(CN3CCCC3)cc2C1 CHEMBL3979773 Ki 9.3 nM
COc1cc(C(=O)N[C@H](CNC(C)=O)c2ccccc2)ccc1-c1cn[nH]c1 CHEMBL4110514 IC50 9.37 nM
N[C@@H](C(=O)Nc1ccc2c(c1)OCc1cnccc1-2)c1ccccc1 CHEMBL4748727 IC50 9.4 nM
COc1cc(C(=O)NCc2ccc3sccc3c2)ccc1-c1cn[nH]c1 CHEMBL3964208 IC50 9.44 nM
Cc1cc(-c2ncc(C(=O)NCc3cccc(C(=O)Nc4nc5c(s4)CN(C)CC5)c3)s2)ccn1 CHEMBL3680782 IC50 9.5 nM
CN1CCc2ccc(NC(=O)c3cccc([C@H]4CCCN4C(=O)Nc4cccc(C#N)c4)c3)cc2C1 CHEMBL3700979 IC50 9.5 nM
C[C@@H](NC(=O)Nc1ccc(C(N)=O)cc1)c1cccc(C(=O)Nc2ccc3c(c2)CN(C)CC3)c1 CHEMBL3704394 IC50 9.5 nM
CN1CCc2nc(NC(=O)c3cccc([C@H](NC(=O)Nc4cccc(C#N)c4)C4CC4)c3)sc2C1 CHEMBL3704396 IC50 9.7 nM
CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4csc(-c5cccnc5)n4)c3)cc2C1 CHEMBL3680706 IC50 9.8 nM
Cc1cc(C(=O)NCc2c(F)cccc2Cl)ccc1-c1cn[nH]c1 CHEMBL3921203 IC50 9.83 nM