CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1 CHEMBL38 IC50 0.15 nM
CC[C@H](NC(=O)c1cc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)cc(C2(C)CC2)c1)C(F)(F)F CHEMBL4129790 Kd 3.3 nM
C[C@H](NS(=O)(=O)c1cc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)cc(C(C)(C)C)c1)C(F)(F)F CHEMBL4128427 IC50 3.4 nM
CCS(=O)(=O)c1ccc(CNC(=O)c2nc(CC3CCCCC3)c(-c3ccc(S(=O)(=O)NC(C)(C)C)c4ccccc34)s2)cc1 CHEMBL4130294 Kd 4.7 nM
CC(C)(C)c1cc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)cc(C(O)(C(F)(F)F)C(F)(F)F)c1 CHEMBL4126690 Kd 10.0 nM
C[C@H](NC(=O)c1cc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)cc(C2(C)CC2)c1)C(F)(F)F CHEMBL4128042 Kd 13.0 nM
CC(C)Oc1cc(Br)cc(-c2ccsc2C(=O)c2ccccc2Cl)c1 CHEMBL4292343 IC50 15.0 nM
C[C@H](NS(=O)(=O)c1ccc(-c2sc(-c3nnc(CC(C)(C)C(=O)O)s3)nc2CC2CCC2)c(Cl)c1Cl)C(F)(F)F CHEMBL4632490 IC50 16.0 nM
CC(C)(C)NC(=O)c1cc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)cc(C2(C)CC2)c1 CHEMBL4126534 Kd 18.0 nM
O=C(c1ccccc1Cl)c1scnc1-c1cc(Br)cc(C(F)(F)F)c1 CHEMBL4289114 IC50 26.0 nM
O=C(c1ccccc1Cl)c1scnc1-c1cccc(C(F)(F)F)c1 CHEMBL4284016 IC50 34.0 nM
Nc1cc(-c2cccc(C(F)(F)F)c2)c(C(=O)c2ccccc2Cl)s1 CHEMBL4276720 IC50 40.0 nM
C[C@H](NC(=O)c1cc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)cc(C(C)(C)C)c1)C(F)(F)F CHEMBL4127926 Kd 43.0 nM
C[C@H](NS(=O)(=O)c1ccc(-c2sc(-c3cc(CC(C)(C)C(=O)O)ncn3)nc2CC2CCC2)c(Cl)c1Cl)C(F)(F)F CHEMBL4649210 IC50 50.0 nM
CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(-c3ccccc3Cl)c(C(=O)c3ccccc3Cl)s2)cc1 CHEMBL4225808 IC50 59.0 nM
C[C@H](NS(=O)(=O)c1ccc(-c2sc(-c3nnc(CC(C)(C)C(=O)O)o3)nc2CN2CCCC(F)(F)C2)c(C(F)F)c1F)C(F)(F)F CHEMBL4642674 Kd 62.0 nM
Nc1nc(-c2cc(Br)cc(C(F)(F)F)c2)c(C(=O)c2ccccc2Cl)s1 CHEMBL4226645 IC50 63.0 nM
CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(-c3cccc(Cl)c3)c(C(=O)c3ccccc3Cl)s2)cc1 CHEMBL3105681 pIC50 63.1 nM
COc1ccccc1C(=O)c1sc(N)cc1-c1cccc(C(F)(F)F)c1 CHEMBL4291888 IC50 76.0 nM
C[C@H](NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12)C(F)(F)F CHEMBL4127282 Kd 86.0 nM
O=C(c1ccccc1Cl)c1sccc1-c1ccnc(Cl)c1 CHEMBL4284644 IC50 87.0 nM
Nc1nc(-c2cccc(C(F)(F)F)c2)c(C(=O)c2ccccc2C(F)(F)F)s1 CHEMBL4225823 IC50 90.0 nM
Nc1ccc(C(=O)c2ccccc2Cl)c(-c2cccc(C(F)(F)F)c2)c1 CHEMBL4293341 IC50 90.0 nM
O=C(c1ccccc1Cl)c1sccc1-c1cccc2ccccc12 CHEMBL4286904 IC50 90.0 nM
COc1ccccc1C(=O)c1scnc1-c1cccc(C(F)(F)F)c1 CHEMBL4288028 IC50 94.0 nM
Nc1nc(-c2cccc(C(F)(F)F)c2)c(C(=O)c2ccccc2Br)s1 CHEMBL4226392 IC50 110.0 nM
CC[C@H](NS(=O)(=O)c1ccc(-c2sc(CC(C)(C)C(=O)O)nc2CC2CCC2)c(Cl)c1Cl)C(F)(F)F CHEMBL4647899 Kd 115.0 nM
Nc1nc(-c2ccc(Cl)c(C(F)(F)F)c2)c(C(=O)c2ccccc2Cl)s1 CHEMBL4227190 IC50 120.0 nM
Nc1nc(-c2cccc(C(F)(F)F)c2)c(C(=O)c2c(F)cccc2C(F)(F)F)s1 CHEMBL4228640 IC50 130.0 nM
COc1ccccc1C(=O)c1sc(N)cc1-c1cccc(Cl)c1 CHEMBL4281271 IC50 130.0 nM
Nc1nc(-c2cc(Cl)cc(C(F)(F)F)c2)c(C(=O)c2ccccc2Cl)s1 CHEMBL4227927 IC50 140.0 nM
C[C@H](NS(=O)(=O)c1ccc(-c2sc(-c3cnc(CC(C)(C)C(=O)O)s3)nc2CC2CCC2)c(Cl)c1Cl)C(F)(F)F CHEMBL4645288 IC50 148.0 nM
CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2c1CCCC2 CHEMBL4126366 IC50 154.0 nM
COc1ccccc1C(=O)c1sc(N)nc1-c1ccc(Cl)c(C(F)(F)F)c1 CHEMBL4225264 IC50 160.0 nM
COc1ccccc1C(=O)c1sc(N)nc1-c1cc(Br)cc(C(F)(F)F)c1 CHEMBL4227867 IC50 160.0 nM
CC(C)(O)CNC(=O)c1nc(CC2CCCCC2)c(-c2ccc(S(=O)(=O)NC3(C#N)CC3)c3ccccc23)s1 CHEMBL4128262 IC50 163.0 nM
CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 CHEMBL4128926 IC50 164.0 nM
C[C@H](NS(=O)(=O)c1ccc(-c2sc(C(=O)NCC(C)(C)O)nc2CC2CC(F)(F)C2)c2ccccc12)C(F)(F)F CHEMBL4130137 IC50 176.0 nM
O=C(c1ccccc1Cl)c1ccccc1-c1cccc(C(F)(F)F)c1 CHEMBL4290788 IC50 180.0 nM
COc1ccccc1C(=O)c1sccc1-c1cccc(Cl)c1 CHEMBL4284441 IC50 180.0 nM
C[C@H](NS(=O)(=O)c1ccc(-c2sc(C(=O)NCC(C)(C)O)nc2Cc2ccc(F)cc2)c(Cl)c1Cl)C(F)(F)F CHEMBL4126317 IC50 184.0 nM
C[C@H](NS(=O)(=O)c1ccc(-c2sc(-c3cc(CC(C)(C)C(=O)O)on3)nc2CC2CCC2)c(Cl)c1Cl)C(F)(F)F CHEMBL4649094 IC50 189.0 nM
C[C@H](NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCC2)c2ccccc12)C(F)(F)F CHEMBL4129634 Kd 200.0 nM
COc1ccccc1C(=O)c1sc(N)cc1-c1cc(Cl)cc(Cl)c1 CHEMBL4276733 IC50 200.0 nM
COc1ccccc1C(=O)c1sccc1-c1cccc(C(F)(F)F)c1 CHEMBL4288937 IC50 220.0 nM
O=C(c1ccccc1Cl)c1sccc1-c1cccc(C(F)(F)F)c1 CHEMBL4285419 IC50 230.0 nM
COc1ccccc1C(=O)c1sccc1-c1ccnc(Cl)c1 CHEMBL4281036 IC50 230.0 nM
CCC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 CHEMBL4128575 Kd 240.0 nM
Nc1nc(-c2cccc(Cl)c2)c(C(=O)c2ccccc2Cl)s1 CHEMBL4226071 IC50 240.0 nM
Nc1cc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(C(=O)c2ccccc2Cl)s1 CHEMBL4292696 IC50 240.0 nM
Nc1nc(-c2ccc(Br)c(C(F)(F)F)c2)c(C(=O)c2ccccc2Cl)s1 CHEMBL4226334 IC50 290.0 nM
COc1ccccc1C(=O)c1sc(N)nc1-c1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL4225424 IC50 290.0 nM
Nc1nc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(C(=O)c2ccccc2Cl)s1 CHEMBL4227134 IC50 310.0 nM
CCC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c(Cl)c1C CHEMBL3314002 IC50 326.0 nM
C[C@H](NC(=O)c1cc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)cc(C2(C#N)CC2)c1)C(F)(F)F CHEMBL4129421 Kd 330.0 nM
COc1ccccc1C(=O)c1sc(N)cc1-c1ccnc(Cl)c1 CHEMBL4284673 IC50 330.0 nM
O=C(c1ccccc1Cl)c1sccc1-c1cccc(-c2ccccc2)c1 CHEMBL4277389 IC50 360.0 nM
COc1ccccc1C(=O)c1sc(N)nc1-c1cccc(C(F)(F)F)c1 CHEMBL4228057 IC50 370.0 nM
O=C(c1ccccc1Cl)c1sccc1-c1ccc2c(c1)OCO2 CHEMBL4285780 IC50 380.0 nM
Nc1nc(-c2cccc(Br)c2)c(C(=O)c2ccccc2Cl)s1 CHEMBL4227440 IC50 410.0 nM
Nc1nc(-c2cccc(C(F)(F)F)c2)c(C(=O)c2c(F)cccc2Cl)s1 CHEMBL4228577 IC50 410.0 nM
Cc1c(S(=O)(=O)NC(C)(C)C)ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c1OC(F)F CHEMBL4130056 IC50 425.0 nM
O=C(c1ccccc1Cl)c1sccc1-c1ccc(Cl)c(Cl)c1 CHEMBL4293998 IC50 470.0 nM
O=C(c1ccccc1Cl)c1sccc1-c1cccc(Cl)c1 CHEMBL4283486 IC50 570.0 nM
[2H]C([2H])([2H])N(C(=O)c1c(Cl)cccc1Cl)c1ccc(-c2cc(NC(C)=O)nn2C(C)C)cc1N1CC2CC2C1 CHEMBL3598052 EC50 600.0 nM
Nc1nc(-c2cccc(C(F)(F)F)c2)c(C(=O)c2ccccc2Cl)s1 CHEMBL4229273 IC50 610.0 nM
CC(C)(CCF)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 CHEMBL4127189 Kd 640.0 nM
COC(C)(C)Cc1nc(-c2nnc(CC(C)(C)C(=O)O)o2)sc1-c1ccc(S(=O)(=O)N[C@@H](C)C(F)(F)F)c(F)c1C(F)F CHEMBL4641039 Kd 675.0 nM
C[C@H](NS(=O)(=O)c1ccc(-c2sc(-c3nnc([C@H]4C[C@H](C(=O)O)C4)o3)nc2CC2CCC2)c(Cl)c1Cl)C(F)(F)F CHEMBL4634072 IC50 725.0 nM
CC(C)[C@H](NS(=O)(=O)c1ccc(-c2sc(C(=O)NCC(C)(C)O)nc2C(=O)N2CCC(F)CC2)c(Cl)c1Cl)C(F)(F)F CHEMBL4644895 Activity 733.0 nM
CC[C@H](NS(=O)(=O)c1ccc(-c2sc(C(=O)NCC(C)(C)O)nc2C(=O)N2CCC(F)(F)CC2)c(Cl)c1Cl)C(F)(F)F CHEMBL4636441 Activity 744.0 nM
[2H]C([2H])([2H])N(C(=O)c1c(F)cccc1Cl)c1ccc(-c2cc(NC(C)=O)nn2C(C)C)cc1N1CCCCC1 CHEMBL3598049 EC50 800.0 nM
CC(=O)Nc1nc(C(C)C)c(-c2cnc(N(C)C(=O)c3c(F)cccc3Cl)c(N3CCCCC3)c2)s1 CHEMBL3598077 EC50 800.0 nM
O=C(c1ccc(Cl)c(Cl)c1)c1scnc1-c1cccc(Cl)c1 CHEMBL4285720 IC50 800.0 nM
C[C@H](NS(=O)(=O)c1ccc(-c2sc(-c3nnc(CC(C)(C)C(=O)O)o3)nc2Cc2ccc(F)cc2)c(C(F)F)c1F)C(F)(F)F CHEMBL4633899 Kd 831.0 nM
[2H]C([2H])([2H])N(C(=O)c1c(F)cccc1Cl)c1ccc(-c2cc(NC(C)=O)nn2C(C)C)cc1OCC1CCC1 CHEMBL3598044 EC50 900.0 nM
CC(C)Cc1nc(-c2nnc(CC(C)(C)C(=O)O)o2)sc1-c1ccc(S(=O)(=O)N[C@@H](C)C(F)(F)F)c(F)c1C(F)F CHEMBL4637003 Kd 949.0 nM
CC[C@H](NS(=O)(=O)c1ccc(-c2sc(-c3nnc(CC(C)(C)C(=O)O)o3)nc2CC2CCCCC2)c(C(F)F)c1F)C(F)(F)F CHEMBL4642631 IC50 951.0 nM
CC(C)(C)c1ccc(-c2ccsc2C(=O)c2ccccc2Cl)cc1 CHEMBL4292527 IC50 980.0 nM
[2H]C([2H])([2H])N(C(=O)c1c(F)cccc1Cl)c1ccc(-c2cc(NC(C)=O)nn2C(C)C)cc1N1CCCC1 CHEMBL3598048 EC50 1000.0 nM
C[C@H](NS(=O)(=O)c1ccc(-c2sc(-c3noc(CC(C)(C)C(=O)O)n3)nc2CC2CCC2)c(Cl)c1Cl)C(F)(F)F CHEMBL4632527 Kd 1000.0 nM