CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.09 nM
CN[C@H]1CC2OC([C@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(O)=NC4 CHEMBL3975634 IC50 0.19 nM
CCn1c(-c2nonc2N)nc2c(C#CCO)ncc(OCCCN)c21 CHEMBL523523 IC50 1.0 nM
CC(C)CCN1c2nc(Nc3cc(F)c(O)c(F)c3)ncc2N(C)C(=O)C1C CHEMBL573107 IC50 3.0 nM
Cn1cnc(COc2ccc3c(c2)C(C)(O)O[C@]32CC[C@H](n3c(-c4nonc4N)nc4cc(F)ccc43)CC2)n1 CHEMBL5276100 IC50 3.0 nM
COCC1CN(C2CCN(c3cc(OC)c(Nc4ncc(Br)c(Nc5ccc6c(c5P(C)(C)=O)OCCO6)n4)cc3C)CC2)C1 CHEMBL5188373 IC50 4.0 nM
Oc1c(F)cc(-c2cnccc2-c2ccc(N3CCOCC3)cc2)cc1F CHEMBL3604794 IC50 5.0 nM
CN(C)CCn1cc(-c2ccn3c(-c4ccc(C(N)=O)c(OCc5cccc(F)c5)c4)cnc3c2)cn1 CHEMBL4062453 IC50 5.4 nM
COc1ccc([C@@H]2CN(C)C[C@H]2NC(=O)c2ccc3cnc(Nc4cc(C)nn4C)cc3c2)cc1 CHEMBL3964006 IC50 5.47 nM
CC[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)cc2n1)c1ccc(OC)c(F)c1 CHEMBL4112587 IC50 5.96 nM
CCn1c(-c2nonc2N)nc2c(C#CCCO)ncc(OCCCN)c21 CHEMBL493875 IC50 6.0 nM
CN1CCN(c2ccc(-c3ccncc3-c3cc(F)c(O)c(F)c3)cc2)CC1 CHEMBL3604793 IC50 6.0 nM
CC[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)cc2c1)c1ccc(Cl)c(F)c1 CHEMBL4115564 IC50 8.5 nM
CCc1ccccc1C(=O)Nc1n[nH]c2c(C)c(F)c(C3C(C#N)=C(C)N(C)C(C)=C3C#N)cc12 CHEMBL4580220 IC50 9.0 nM
Cn1nccc1Nc1cc2nc(C(=O)N[C@H](CO)c3ccc(Cl)c(F)c3)ccc2cn1 CHEMBL4108790 IC50 9.84 nM
Cn1cc([C@@H](NC(=O)c2ccc3cnc(Nc4ccnn4C)cc3c2)c2ccc(Cl)c(F)c2)cn1 CHEMBL3976074 IC50 9.97 nM
CCn1c(-c2nonc2N)nc2c(-c3ccc[nH]3)ncc(OCCCN)c21 CHEMBL493251 IC50 13.0 nM
O=C(N[C@H](CO)c1ccc(Cl)c(F)c1)c1ccc2cnc(NC3CCOCC3)cc2c1 CHEMBL4113272 IC50 14.8 nM
CC[C@@H](NC(=O)c1ccc2cnc(Nc3cc(C)nn3C)cc2c1)c1ccc(Cl)c(F)c1 CHEMBL4108819 IC50 15.7 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 16.0 nM
O=C(N[C@H](CO)c1ccc(Cl)c(F)c1)c1ccc2cnc(NC3CCOCC3)cc2n1 CHEMBL4112022 IC50 16.3 nM
COc1ccc([C@H](NC(=O)c2ccc3cnc(NC4CCOCC4)cc3n2)c2cnn(C)c2)cc1F CHEMBL3920757 IC50 18.7 nM
C[C@@H]1CC(=O)Nc2ncnc(N3CCC(c4nc(-c5ccc(F)c(C(F)(F)F)c5)cn4CCN4CCCC4)CC3)c21 CHEMBL4128457 IC50 20.0 nM
CCn1c(-c2nonc2N)nc2cnccc21 CHEMBL189657 IC50 24.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 28.0 nM
COc1ccc([C@H](NC(=O)c2ccc3cnc(Nc4cc(C)nn4C)cc3c2)c2cnn(C)c2)cc1F CHEMBL3969698 IC50 30.4 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CN[C@H](CCO)C[C@H]2c2ccc(F)c(F)c2)oc1Cl CHEMBL4441825 IC50 32.0 nM
CCn1c(-c2nonc2N)nc2cncc(C(=O)N3CC[C@H](N)C3)c21 CHEMBL1956071 IC50 35.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 36.0 nM
C=CC(=O)N1C[C@@H]2CCOc3c(Cl)c(-c4c(O)cccc4F)c(F)c4ncnc(c34)N2C[C@H]1C CHEMBL5183988 IC50 36.0 nM
COc1ccc([C@H](NC(=O)c2ccc3cnc(N[C@@H](C)CO)cc3n2)c2cnn(C)c2)cc1F CHEMBL3953138 IC50 37.8 nM
CCn1c(-c2nonc2N)nc2c(-c3ccccc3)ncc(OCCCN)c21 CHEMBL493250 IC50 44.0 nM
Cn1cc(/C=C2\Oc3cccc(O)c3C2=O)c2c(-c3ccc(C(=O)NCCO)cc3)ccnc21 CHEMBL1092754 IC50 45.9 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CNCC[C@H]2c2ccc(F)c(F)c2)oc1Cl CHEMBL4457064 IC50 48.0 nM
COc1c(Nc2ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)ccc2c1CC[C@@H](N1CCOCC1)CC2 CHEMBL2064666 IC50 61.0 nM
C[C@@H](CO)Nc1cc2cc(C(=O)NCc3cc4c(F)cccc4[nH]3)ccc2cn1 CHEMBL3925797 IC50 65.1 nM
CCn1c(-c2nonc2N)nc2c(-c3ccoc3)ncc(OCCCN)c21 CHEMBL445180 IC50 71.0 nM
CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]c(F)c(c3c2)-c2cn(nc2C(F)(F)F)CCCC1=O CHEMBL5086263 IC50 82.0 nM
NC[C@@](O)(c1ccc(Cl)cc1)c1ccc(-c2cn[nH]c2)cc1 CHEMBL3544960 IC50 85.0 nM
CC(=O)O[C@@H]1[C@@H](OC(C)=O)[C@@H](O)[C@H](Oc2c(-c3ccc(O)cc3)oc3cc(O)cc(O)c3c2=O)O[C@H]1C CHEMBL240954 IC50 89.0 nM
CC1=C(C(=O)Nc2cc(Cl)c3[nH]ncc3c2)C(c2ccc(C(F)(F)F)cc2)CC(=O)N1 CHEMBL427058 IC50 90.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 96.0 nM
O=C(NCc1ccc(Cl)c(F)c1)c1ccc2cnc(NC3CCOCC3)cc2n1 CHEMBL3963644 IC50 98.9 nM
Cn1cc(C2=C(c3ccc(Cl)cc3Cl)C(=O)NC2=O)c2ccccc21 CHEMBL102714 IC50 100.0 nM
O=C1Nc2ccccc2/C1=C1/Nc2ccccc2/C1=N\O CHEMBL216543 IC50 100.0 nM
N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL1789941 Kd 120.0 nM
CNC(=O)C[C@@H]1C[C@@H](c2ccc(F)c(F)c2)[C@H](NC(=O)c2cc(-c3c(Cl)cnn3C)c(Cl)o2)CN1 CHEMBL4440965 IC50 131.0 nM
CCn1c(-c2nonc2N)nc2cnc(Oc3cccc(NC(=O)c4ccc(OCCN5CCOCC5)cc4)c3)cc21 CHEMBL220241 IC50 132.0 nM
CCn1c(-c2nonc2N)nc2cncc(CNC3CCNCC3)c21 CHEMBL188434 IC50 155.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 160.0 nM
Oc1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL278041 Kd 170.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 180.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 180.0 nM
Cn1cc(C2=C(c3cn(CCCSC(=N)N)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL6291 IC50 200.0 nM
c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)ccn1 CHEMBL478629 IC50 210.0 nM
c1cc(-c2cnc3c(-c4cn[nH]c4)cnn3c2)ccc1OCCN1CCOCC1 CHEMBL1271532 IC50 220.0 nM
Nc1nc(N)c2nc(-c3cccc(O)c3)c(-c3cccc(O)c3)nc2n1 CHEMBL230011 Kd 220.0 nM
CCn1c(-c2nonc2N)nc2c(C#CCN)ncc(OCCCN)c21 CHEMBL1794064 IC50 251.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC3CC3)ncc(OCCCN)c21 CHEMBL494882 IC50 251.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 251.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 260.0 nM
C[C@@H]1CC(=O)Nc2ncnc(N3CCC(c4nc(C(F)(F)F)cn4CCN4CCCC4)CC3)c21 CHEMBL4129817 IC50 272.0 nM
NC(=O)C(Nc1c(Nc2ccncc2)c(=O)c1=O)c1cccc(O)c1 CHEMBL511410 IC50 290.0 nM
CC(C)n1nc(-c2cc(C3CC3)on2)c2c(N)ncnc21 CHEMBL3753341 IC50 311.0 nM
C[S+]([O-])c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL10 Kd 320.0 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@H](CN)Cc2ccc(F)c(F)c2)oc1Cl CHEMBL3137336 IC50 339.0 nM
N#Cc1cnc(Nc2cc(NC[C@H]3CNCCO3)c(C(F)(F)F)cn2)cn1 CHEMBL4169078 IC50 362.0 nM
CC1=C(C(=O)Nc2cc3cn[nH]c3cc2F)C(c2ccc(Cl)cc2F)N=C(c2ccnc(Cl)c2)N1 CHEMBL521347 IC50 398.0 nM
CN(C)C[C@@H]1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1 CHEMBL91829 Kd 400.0 nM
COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 CHEMBL24828 Kd 400.0 nM
CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3c(cc2OC)CCN3C(=O)CN(C)C)nc2[nH]ccc12 CHEMBL464552 Kd 410.0 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 Kd 420.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 Kd 450.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 471.0 nM
O=C(NCCc1ccc(Cl)c(F)c1)c1ccc2cnc(NC3CCOCC3)cc2n1 CHEMBL3903344 IC50 476.0 nM
COc1cccc(Cn2cnc3ccc(-c4cn[nH]c4)cc3c2=O)c1 CHEMBL4742990 IC50 483.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 490.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OCCN)c21 CHEMBL453510 IC50 500.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OCCCNC[C@H](O)CO)c21 CHEMBL522351 IC50 500.0 nM
COc1ccc(C2=NC(c3ccc(Cl)cc3F)C(C(=O)Nc3ccc4[nH]ncc4c3)=C(C)N2)cc1 CHEMBL520828 IC50 510.0 nM
Nc1nc2c(-c3ccccn3)nccc2[nH]1 CHEMBL2153264 Kd 530.0 nM
Cc1ccc(NC(=O)c2ccc(C)c(C(F)(F)F)c2)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12 CHEMBL4798527 IC50 559.0 nM
Oc1ccc(-c2cnn3cc(-c4ccc(OCCN5CCOCC5)cc4)cnc23)cc1O CHEMBL1271641 IC50 560.0 nM
C[C@@H]1CC(=O)Nc2ncnc(N3CCC(c4nc(CCC(F)(F)F)cn4CCN4CCCC4)CC3)c21 CHEMBL4129379 IC50 568.0 nM
CN(C)CCCn1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL7463 IC50 610.0 nM
CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc(Cl)c(Cl)c2)CC(=O)N1 CHEMBL374453 IC50 620.0 nM
C[C@@H]1CC(=O)Nc2ncnc(N3CCC(c4nc(C5CCOCC5)cn4CCN4CCCC4)CC3)c21 CHEMBL4126067 IC50 699.0 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1 CHEMBL428690 Kd 720.0 nM
CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc(C(F)(F)F)cc2)CC(=O)N1 CHEMBL218719 IC50 740.0 nM
Cn1nccc1-c1ccc(C(=O)N[C@@H]2CNCC[C@H]2c2ccc(F)c(F)c2)c(F)c1 CHEMBL4556790 IC50 756.0 nM
CC1=C(C(=O)Nc2cc3cn[nH]c3cc2F)C(c2ccc(C(F)(F)F)cc2)CC(=O)N1 CHEMBL375312 IC50 780.0 nM
NC(=O)C(Nc1c(Nc2ccncc2)c(=O)c1=O)c1ccccc1 CHEMBL467079 IC50 780.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OCCCCN)c21 CHEMBL493269 IC50 790.0 nM
CCNC(=O)C#Cc1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN(C)C)cc1)c1ccccc1 CHEMBL3699142 Kd apparent 799.0 nM
C[C@@H](Nc1c(Nc2ccncc2)c(=O)c1=O)c1ccccc1 CHEMBL466496 IC50 810.0 nM
Cc1nc(Nc2n[nH]c3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)c2sccc2n1 CHEMBL3128043 Kd apparent 820.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM