CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.14 nM
C[C@@H]1NC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n2[C@@H]1C CHEMBL3956539 IC50 0.18 nM
CCn1c(NC(=O)c2ccc3cc4n(c3c2)C(C)(C)CNC4=O)nc2ccccc21 CHEMBL3945993 IC50 0.25 nM
CN(C)CCCn1c(NC(=O)c2ccc3cc4n(c3c2)C(C)(C)CNC4=O)nc2ccccc21 CHEMBL3903528 IC50 0.38 nM
C[C@@H]1NC(=O)c2cc3ccc(C(=O)Nc4cnn(Cc5ccccc5)c4)cc3n2[C@@H]1C CHEMBL3900064 IC50 0.42 nM
CC1CNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5[nH]4)cc3n21 CHEMBL3959915 IC50 0.59 nM
C[C@@H]1CNC(=O)c2cc3ccc(C(=O)Nc4cnn(Cc5ccccc5)c4)cc3n21 CHEMBL4109143 IC50 0.6 nM
CCn1c(NC(=O)c2ccc3cc4n(c3c2)C(C)CCNC4=O)nc2ccccc21 CHEMBL3955947 IC50 0.6 nM
Cn1c(NC(=O)c2ccc3cc4n(c3c2)C(C)(C)CNC4=O)nc2ccccc21 CHEMBL3908561 IC50 0.62 nM
CCn1c(NC(=O)c2ccc3cc4n(c3c2)C(C)CNC4=O)nc2ccccc21 CHEMBL3972132 IC50 0.63 nM
CCn1c(NC(=O)c2ccc3cc4n(c3c2)[C@@H](C)[C@@H](C)NC4=O)nc2ccccc21 CHEMBL4108521 IC50 0.64 nM
C[C@@H]1CNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n21 CHEMBL4113357 IC50 0.7 nM
C[C@@H]1CCNC(=O)c2cc3ccc(C(=O)Nc4cnn(Cc5ccccc5)c4)cc3n21 CHEMBL4111661 IC50 0.71 nM
CC1CCNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5[nH]4)cc3n21 CHEMBL3951802 IC50 0.77 nM
CC1(C)CNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5[nH]4)cc3n21 CHEMBL3985027 IC50 0.89 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 IC50 1.0 nM
CCn1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2ccccc21 CHEMBL1933280 IC50 1.1 nM
C[C@@H]1CCNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n21 CHEMBL1933288 IC50 1.1 nM
CC1CNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n21 CHEMBL3939884 IC50 1.3 nM
CC1CCNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n21 CHEMBL3942136 IC50 1.3 nM
CC(C)n1c(NC(=O)c2ccc3cc4n(c3c2)[C@H](C)CCNC4=O)nc2ccccc21 CHEMBL4112559 IC50 1.4 nM
CC1CCNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4C)cc3n21 CHEMBL3918100 IC50 1.6 nM
CC(C)n1c(NC(=O)c2ccc3cc4n(c3c2)[C@@H](C)[C@@H](C)CNC4=O)nc2ccccc21 CHEMBL3904474 IC50 1.8 nM
CC1(C)CNC(=O)c2cc3ccc(C(=O)Nc4cnn(Cc5ccccc5)c4)cc3n21 CHEMBL3963988 IC50 1.8 nM
CC(C)n1c(NC(=O)c2ccc3cc4n(c3c2)C(C)CCNC4=O)nc2ccccc21 CHEMBL3900130 IC50 1.8 nM
Cc1cc(C)cc(Cn2cc(NC(=O)c3ccc4cc5n(c4c3)CCCNC5=O)cn2)c1 CHEMBL3980724 IC50 1.9 nM
C[C@H]1NC(=O)c2cc3ccc(C(=O)Nc4cnn(Cc5ccccc5)c4)cc3n2[C@H]1C CHEMBL4113926 IC50 1.9 nM
CC(C)n1c(NC(=O)c2ccc3cc4n(c3c2)[C@H](C)CNC4=O)nc2ccccc21 CHEMBL4109800 IC50 1.9 nM
O=C(Nc1cnn(Cc2ccncc2)c1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1933278 IC50 1.9 nM
CC(C)n1c(NC(=O)c2ccc3cc4n(c3c2)C(C)(C)CCNC4=O)nc2ccccc21 CHEMBL3965519 IC50 2.0 nM
C[C@H]1CNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n2[C@H]1C CHEMBL3910099 IC50 2.0 nM
C[C@H]1NC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n2[C@H]1C CHEMBL4111985 IC50 2.1 nM
CC1CCNC(=O)c2cc3ccc(C(=O)Nc4cn(C)c(C(=O)NC5CCCC5)n4)cc3n21 CHEMBL3966733 IC50 2.1 nM
CC1CNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4C)cc3n21 CHEMBL3969149 IC50 2.2 nM
CC1CCNC(=O)c2cc3ccc(C(=O)Nc4nc5cc(Cl)ccc5[nH]4)cc3n21 CHEMBL3946668 IC50 2.5 nM
CN1CCN(c2ccc3[nH]c(NC(=O)c4ccc5cc6n(c5c4)CCCNC6=O)nc3c2)CC1 CHEMBL3917125 IC50 2.6 nM
Cc1ccc2[nH]c(NC(=O)c3ccc4cc5n(c4c3)CCCNC5=O)nc2c1 CHEMBL3916626 IC50 3.0 nM
CC(C)n1c(NC(=O)c2ccc3cc4n(c3c2)[C@@H](C)[C@@H](C)NC4=O)nc2ccccc21 CHEMBL4107750 IC50 3.4 nM
CCCS(=O)(=O)c1ccc2[nH]c(NC(=O)c3ccc4cc5n(c4c3)CCCNC5=O)nc2c1 CHEMBL4110776 IC50 3.6 nM
Cn1cc(NC(=O)c2ccc3cc4n(c3c2)C(C)(C)CNC4=O)nc1C(=O)NC1CCCC1 CHEMBL1933142 IC50 3.7 nM
CN(C)c1cccc(Cn2cc(NC(=O)c3ccc4cc5n(c4c3)CCCNC5=O)cn2)c1 CHEMBL3936149 IC50 3.8 nM
COc1cc(Nc2nc3cccc(-c4cccc5[nH]cnc45)c3o2)cc(OC)c1OC CHEMBL3298194 IC50 4.0 nM
O=C(Nc1cnn(Cc2ccccc2)c1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3921354 IC50 4.0 nM
Cc1cc(NC(=O)c2ccc3cc4n(c3c2)[C@H](C)[C@H](C)NC4=O)no1 CHEMBL3916789 IC50 4.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 4.0 nM
Oc1c(F)cc(-c2cnccc2-c2ccc(N3CCOCC3)cc2)cc1F CHEMBL3604794 IC50 4.0 nM
CN1CCN(c2ccc(-c3ccncc3-c3cc(F)c(O)c(F)c3)cc2)CC1 CHEMBL3604793 IC50 4.0 nM
C[C@H]1NC(=O)c2cc3ccc(C(=O)Nc4cnn(C)c4)cc3n2[C@H]1C CHEMBL4108963 IC50 4.3 nM
O=C(Nc1nc2ccccc2[nH]1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938803 IC50 4.4 nM
CCn1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2cccnc21 CHEMBL1933287 IC50 4.4 nM
CCn1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2cc(C)ccc21 CHEMBL3941501 IC50 4.8 nM
O=C(Nc1nc2ccccc2n1CC(F)(F)F)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3955733 IC50 4.8 nM
N#Cc1ccc2[nH]c(NC(=O)c3ccc4cc5n(c4c3)CCCNC5=O)nc2c1 CHEMBL3912033 IC50 4.9 nM
CCn1c(NC(=O)c2ccc3cc4n(c3c2)[C@@H](C)[C@H](C)NC4=O)nc2ccccc21 CHEMBL3961025 IC50 5.0 nM
CC1CNC(=O)c2cc3ccc(C(=O)Nc4cnn(C)c4)cc3n21 CHEMBL3981684 IC50 5.1 nM
O=C(Nc1nc2cc(F)ccc2[nH]1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3917267 IC50 5.2 nM
CC(C)(O)Cn1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2ccccc21 CHEMBL3947009 IC50 5.4 nM
CC(C)(O)Cn1c(NC(=O)c2ccc3cc4n(c3c2)CC(C)(C)CNC4=O)nc2ccccc21 CHEMBL3924643 IC50 5.9 nM
Cn1cc(NC(=O)c2ccc3cc4n(c3c2)C(C)(C)CNC4=O)nc1C(=O)NC(C)(C)C CHEMBL3904372 IC50 6.0 nM
CC(C)c1ccc2[nH]c(NC(=O)c3ccc4cc5n(c4c3)CCCNC5=O)nc2c1 CHEMBL3954642 IC50 6.2 nM
Cc1cc(NC(=O)c2ccc3cc4n(c3c2)[C@H](C)CNC4=O)no1 CHEMBL4112688 IC50 6.6 nM
COc1c(Nc2ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)ccc2c1CC[C@@H](N1CCOCC1)CC2 CHEMBL2064666 IC50 7.0 nM
CC(C)n1c(NC(=O)c2ccc3cc4n(c3c2)C(C)CNC4=O)nc2ccccc21 CHEMBL3909595 IC50 7.3 nM
O=C(Nc1cnn(CC2CCCCC2)c1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1933149 IC50 7.4 nM
CC1CNC(=O)c2cc3ccc(C(=O)Nc4cnn(Cc5ccccc5)c4)cc3n2C1 CHEMBL3979890 IC50 7.6 nM
Cc1ccccc1Cn1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)cn1 CHEMBL3893357 IC50 7.9 nM
O=C(Nc1nc2cc(Cl)ccc2[nH]1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3907067 IC50 8.0 nM
CC1CNC(=O)c2cc3ccc(C(=O)Nc4cc5ccccc5[nH]4)cc3n21 CHEMBL3973993 IC50 8.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 8.0 nM
CC(C)n1ncc2cc(NC(=O)c3ccc4cc5n(c4c3)[C@@H](C)[C@@H](C)NC5=O)cnc21 CHEMBL4110640 IC50 8.1 nM
CC1CNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4C)cc3n2C1 CHEMBL3950889 IC50 8.2 nM
CC1(C)CNC(=O)c2cc3ccc(C(=O)Nc4ccccc4C(N)=O)cc3n21 CHEMBL3977541 IC50 8.2 nM
C[C@@H]1NC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n2[C@H]1C CHEMBL3964098 IC50 8.5 nM
O=C(Nc1nc2cc(Cl)cc(CN3CCOCC3)c2[nH]1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3936241 IC50 8.7 nM
Cn1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2ccccc21 CHEMBL1933279 IC50 9.0 nM
Cn1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc1C(=O)NC1CCCC1 CHEMBL3893525 IC50 9.0 nM
COc1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)ncn1 CHEMBL3899642 IC50 9.1 nM
CN(C)CCCn1c(NC(=O)c2ccc3cc4n(c3c2)CC2(CC2)CNC4=O)nc2ccccc21 CHEMBL3949573 IC50 9.25 nM
C[C@H]1CNC(=O)c2cc3ccc(C(=O)Nc4cnn(Cc5ccccc5)c4)cc3n2[C@H]1C CHEMBL3944581 IC50 9.3 nM
COc1ccc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)cc1O[C@H]1CCNC1 CHEMBL3297951 IC50 10.0 nM
Cn1cc(C2=C(c3cn(CCCSC(=N)N)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL6291 IC50 10.0 nM
C[C@@H]1NC(=O)c2cc3ccc(C(=O)Nc4cnn(Cc5ccccc5)c4)cc3n2[C@H]1C CHEMBL3891520 IC50 10.0 nM
CC1CCNC(=O)c2cc3ccc(C(=O)Nc4cnn(C)c4)cc3n21 CHEMBL3938082 IC50 10.0 nM
Cc1nc2ccc(NC(=O)c3ccc4cc5n(c4c3)CCCNC5=O)cc2s1 CHEMBL3952504 IC50 10.0 nM
CCCNC(=O)c1nc(NC(=O)c2ccc3cc4n(c3c2)C(C)CNC4=O)sc1C(C)C CHEMBL3968264 IC50 10.9 nM
Cn1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)cn1 CHEMBL1933148 IC50 11.0 nM
CC(C)CCn1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)cn1 CHEMBL3923698 IC50 11.0 nM
CN(C)CCCn1c(NC(=O)c2ccc3cc4n(c3c2)CC2(CCC2)CNC4=O)nc2ccccc21 CHEMBL3952605 IC50 11.0 nM
O=C(Nc1cnn(Cc2ccccc2)c1)c1ccc2cc3n(c2c1)CC1(CC1)CNC3=O CHEMBL3921790 IC50 11.0 nM
CC1CCNC(=O)c2cc3ccc(C(=O)Nc4ccccc4C(N)=O)cc3n21 CHEMBL3931737 IC50 11.0 nM
CCn1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2ccc(Cl)cc21 CHEMBL1933285 IC50 12.0 nM
Cc1cc(NC(=O)c2ccc3cc4n(c3c2)C(C)CCNC4=O)no1 CHEMBL3905749 IC50 12.0 nM
Cc1cc(NC(=O)c2ccc3cc4n(c3c2)[C@H](C)CCNC4=O)no1 CHEMBL4110939 IC50 12.0 nM
CC1CNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n2C1 CHEMBL3911905 IC50 13.0 nM
CC(C)CCN1c2nc(Nc3cc(F)c(O)c(F)c3)ncc2N(C)C(=O)C1C CHEMBL573107 IC50 13.0 nM
CC(C)n1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)cn1 CHEMBL3892648 IC50 14.0 nM
CN1CCC(n2c(NC(=O)c3ccc4cc5n(c4c3)CCCNC5=O)nc3ccccc32)CC1 CHEMBL3919317 IC50 14.0 nM
C[C@H]1CCNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n21 CHEMBL1933289 IC50 14.0 nM
Cc1ccc(-c2c(C(=O)CF)n(CCCO)c3ncnc(N(C)C)c23)cc1 CHEMBL3779984 IC50 15.0 nM
C[C@H]1CNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n21 CHEMBL3923687 IC50 15.0 nM
CC1(C)CNC(=O)c2cc3ccc(C(=O)Nc4cc(-c5ccccc5)no4)cc3n21 CHEMBL3938374 IC50 15.0 nM
CN(C)CCCn1c(NC(=O)c2ccc3cc4n(c3c2)CC2(CCOCC2)CNC4=O)nc2ccccc21 CHEMBL3937135 IC50 16.0 nM
CCCc1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)on1 CHEMBL3910435 IC50 16.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 17.0 nM
O=C(Nc1cnn(CCc2ccccc2)c1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3941636 IC50 17.0 nM
COc1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)ccn1 CHEMBL3915806 IC50 17.0 nM
C[C@H]1CNC(=O)c2cc3ccc(C(=O)Nc4cnn(Cc5ccccc5)c4)cc3n21 CHEMBL3907405 IC50 17.5 nM
CS(=O)(=O)c1ccc2c(c1)nc(NC(=O)c1ccc3cc4n(c3c1)CCCNC4=O)n2CC(F)(F)F CHEMBL3908897 IC50 18.0 nM
O=C(Nc1cnn(-c2ccccc2)c1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3906949 IC50 18.0 nM
O=C(Nc1cc(C2CC2)no1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1933068 IC50 18.0 nM
COCCn1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)cn1 CHEMBL3978178 IC50 19.0 nM
CC(C)(C)n1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2ccccc21 CHEMBL3962101 IC50 19.0 nM
CC(C)n1ncc2cc(NC(=O)c3ccc4cc5n(c4c3)C(C)CCNC5=O)cnc21 CHEMBL3951696 IC50 19.0 nM
Cc1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)on1 CHEMBL1933143 IC50 19.0 nM
COc1cc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)cc(OC)c1OC CHEMBL3297945 IC50 20.0 nM
COc1ccccc1-c1cccc2nc(Nc3cc(OC)c(OC)c(OC)c3)oc12 CHEMBL3298039 IC50 20.0 nM
CN(C)CCCn1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2ccc(Cl)cc21 CHEMBL1933286 IC50 20.0 nM
Cn1c(NC(=O)c2ccc3cc4n(c3c2)CC(C)(C)CNC4=O)nc2ccccc21 CHEMBL3912727 IC50 20.0 nM
CC(C)n1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2ccccc21 CHEMBL1933281 IC50 20.0 nM
CC(C)n1c(NC(=O)c2ccc3cc4n(c3c2)[C@@H](C)CNC4=O)nc2ccccc21 CHEMBL3898985 IC50 21.0 nM
CN1CCC(Cn2c(NC(=O)c3ccc4cc5n(c4c3)CCCNC5=O)nc3ccccc32)CC1 CHEMBL3925887 IC50 21.0 nM
CN(C)CCCn1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2ccccc21 CHEMBL1933283 IC50 21.0 nM
CC1CCNC(=O)c2cc3ccc(C(=O)Nc4cccc(F)c4)cc3n21 CHEMBL3947938 IC50 21.0 nM
NC(=O)c1ccccc1NC(=O)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938786 IC50 21.0 nM
O=C(Nc1nc2ccccc2n1CCc1ccccn1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3953520 IC50 22.0 nM
CN(C)CCn1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2ccccc21 CHEMBL3938752 IC50 23.0 nM
CN(C)CCCn1c(NC(=O)c2ccc3cc4n(c3c2)CC(F)(F)CNC4=O)nc2ccccc21 CHEMBL3974499 IC50 23.0 nM
O=C(Nc1nc2cc(C(F)(F)F)ccc2[nH]1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3937497 IC50 24.0 nM
CCc1ccccc1C(=O)Nc1n[nH]c2c(C)c(F)c(C3C(C#N)=C(C)N(C)C(C)=C3C#N)cc12 CHEMBL4580220 IC50 24.0 nM
O=C(Nc1nc2ccccc2n1C1CCCC1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3942582 IC50 25.0 nM
CC1CNC(=O)c2cc3ccc(C(=O)Nc4cc(C(C)(C)C)on4)cc3n21 CHEMBL3906539 IC50 25.0 nM
O=C(Nc1ncc[nH]1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938792 IC50 25.5 nM
Cn1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2cc(Cl)ccc21 CHEMBL3920136 IC50 26.0 nM
O=C(Nc1cc(C2CC2)on1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3912056 IC50 26.0 nM
CC(C)c1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)on1 CHEMBL1933145 IC50 26.0 nM
O=C(Nc1cnn(Cc2ccccc2)c1)c1ccc2cc3n(c2c1)CC1(CCC1)CNC3=O CHEMBL3928994 IC50 26.5 nM
O=C(Nc1cnn(C2CCOC2)c1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3969237 IC50 27.0 nM
CN(C)CCCn1c(NC(=O)c2ccc3cc4n(c3c2)CC(C)(C)CNC4=O)nc2ccccc21 CHEMBL1933290 IC50 27.0 nM
CC1(c2cc(NC(=O)c3ccc4cc5n(c4c3)CCCNC5=O)on2)CC1 CHEMBL3943871 IC50 27.0 nM
Cc1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)no1 CHEMBL3985216 IC50 30.0 nM
CN(C)CC(C)(C)Cn1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2ccccc21 CHEMBL3919214 IC50 30.0 nM
O=C(Nc1cc(-c2cccnc2)no1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3902606 IC50 30.0 nM
O=C(Nc1cc(Cc2ccccc2)on1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3972558 IC50 30.0 nM
O=C(Nc1cnn(Cc2ccccc2)c1)c1ccc2cc3n(c2c1)CC(F)(F)CNC3=O CHEMBL3904664 IC50 32.0 nM
CC1CCNC(=O)c2cc3ccc(C(=O)Nc4cc(C(C)(C)C)on4)cc3n21 CHEMBL3923642 IC50 32.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 33.0 nM
CN(C)CCCn1c(NC(=O)c2ccc3cc4n(c3c2)CC(C)(C)CNC4=O)nc2cc(Cl)ccc21 CHEMBL3922600 IC50 34.0 nM
Cc1cc(NC(=O)c2ccc3cc4n(c3c2)C(C)CNC4=O)no1 CHEMBL3894714 IC50 34.0 nM
O=C(Nc1cnc2ccccc2c1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938798 IC50 34.0 nM
CCc1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)no1 CHEMBL3920993 IC50 34.5 nM
Cc1cc(NC(=O)c2ccc3cc4n(c3c2)C(C)(C)CNC4=O)no1 CHEMBL3958213 IC50 36.0 nM
O=C(Nc1ccncc1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938787 IC50 39.0 nM
Cc1ccnc(NC(=O)c2ccc3cc4n(c3c2)C(C)CCNC4=O)c1 CHEMBL3932915 IC50 39.0 nM
O=C(Nc1cc(C2CCCCC2)no1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3930593 IC50 39.0 nM
COc1ccc(F)cc1-c1cccc2nc(Nc3cc(OC)c(OC)c(OC)c3)oc12 CHEMBL3298045 IC50 40.0 nM
COc1cc(C)ccc1-c1cccc2nc(Nc3cc(OC)c(OC)c(OC)c3)oc12 CHEMBL3298046 IC50 40.0 nM
O=C(Nc1cc(-c2ccccc2)[nH]n1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3960426 IC50 40.0 nM
CC1CCNC(=O)c2cc3ccc(C(=O)Nc4cccnc4)cc3n21 CHEMBL1938765 IC50 41.0 nM
O=C(Nc1cccc(-c2cc[nH]n2)c1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3890669 IC50 41.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 42.0 nM
O=C(Nc1cn[nH]c1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938794 IC50 43.0 nM
C[C@@H]1CNC(=O)c2cc3ccc(C(=O)Nc4cnn(Cc5ccccc5)c4)cc3n2[C@H]1C CHEMBL4111610 IC50 43.5 nM
CC(C)(C)c1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)on1 CHEMBL3912437 IC50 44.0 nM
C[C@H]1NC(=O)c2cc3ccc(C(=O)Nc4cccnc4)cc3n2[C@H]1C CHEMBL4111535 IC50 45.0 nM
O=C(Nc1cnn(C2CCOCC2)c1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3898040 IC50 46.0 nM
CC(C)(C)n1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)cn1 CHEMBL3957848 IC50 48.0 nM
COc1cc(Nc2nc3cccc(-c4cccc5cn[nH]c45)c3o2)cc(OC)c1OC CHEMBL3298193 IC50 50.0 nM
CS(=O)(=O)c1ccc2c(c1)nc(NC(=O)c1ccc3cc4n(c3c1)CC1(CCNCC1)CNC4=O)n2CC(F)(F)F CHEMBL3952734 IC50 51.0 nM
O=C(Nc1cccc(-c2c[nH]cn2)c1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938791 IC50 52.0 nM
CC(C)n1ncc2cc(NC(=O)c3ccc4cc5n(c4c3)CCCNC5=O)cnc21 CHEMBL1938799 IC50 53.0 nM
O=C(Nc1nc2ccccc2n1CCN1CCOCC1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3931581 IC50 54.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 58.0 nM
CC(=O)N1CCC(n2c(NC(=O)c3ccc4cc5n(c4c3)CCCNC5=O)nc3ccccc32)CC1 CHEMBL3891232 IC50 58.0 nM
O=C(Nc1cccc(N2CCOCC2)c1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3966940 IC50 60.0 nM
O=C(Nc1nc2ccccc2n1-c1ccccc1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1933282 IC50 61.0 nM
CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]c(F)c(c3c2)-c2cn(nc2C(F)(F)F)CCCC1=O CHEMBL5086263 IC50 61.0 nM
CC(C)c1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)no1 CHEMBL3933995 IC50 66.0 nM
Cc1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)n[nH]1 CHEMBL3985647 IC50 68.0 nM
COc1ccc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)cc1OC CHEMBL3297948 IC50 70.0 nM
O=C(Nc1ccc2ccccc2n1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938800 IC50 70.0 nM
O=C(Nc1ccncn1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3962701 IC50 76.0 nM
C[C@H]1CCNC(=O)c2cc3ccc(C(=O)Nc4cnn(Cc5ccccc5)c4)cc3n21 CHEMBL3960147 IC50 80.0 nM
CN(C)CCCn1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)cn1 CHEMBL3945349 IC50 84.0 nM
O=C(Nc1cnn(CCN2CCOCC2)c1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3965166 IC50 84.0 nM
O=C(Nc1cc(C(F)(F)F)no1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3961193 IC50 85.0 nM
Cn1ncc2cc(NC(=O)c3ccc4cc5n(c4c3)CCCNC5=O)cnc21 CHEMBL3974341 IC50 87.0 nM
O=C(Nc1cc(-c2ccccc2)no1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1933146 IC50 87.0 nM
CC(C)c1ccc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)cc1 CHEMBL3964720 IC50 89.0 nM
O=C(Nc1cc[nH]n1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938796 IC50 93.0 nM
CC(C)(C)c1nnc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)s1 CHEMBL3946956 IC50 96.0 nM
COc1ccnc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)c1 CHEMBL3924810 IC50 96.0 nM
CC(C)(CO)c1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)on1 CHEMBL3937261 IC50 96.0 nM
O=C(Nc1nnc(Cc2ccccc2)s1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3939391 IC50 98.0 nM
N#Cc1ccc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)cc1 CHEMBL3914275 IC50 106.0 nM
O=C(Nc1ccn(-c2ccccc2)n1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3943709 IC50 108.0 nM
Cn1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)ccc1=O CHEMBL3932659 IC50 110.0 nM
CC1(C)CNC(=O)c2cc3ccc(C(=O)Nc4cnn(Cc5ccccc5)c4)cc3n2C1 CHEMBL3948495 IC50 110.0 nM
COc1ccc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)cc1 CHEMBL3892337 IC50 110.0 nM
Cc1ccc(-c2cc(NC(=O)c3ccc4cc5n(c4c3)CCCNC5=O)on2)cc1 CHEMBL3913615 IC50 115.0 nM
CN(C)CCn1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)cn1 CHEMBL3966001 IC50 120.0 nM
CN(C)CCNC(=O)c1ccccc1NC(=O)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3980088 IC50 125.0 nM
N#Cc1cccc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)c1 CHEMBL3905379 IC50 140.0 nM
CC(C)c1cccc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)c1 CHEMBL3980455 IC50 140.0 nM
CC1CNC(=O)c2cc3ccc(C(=O)Nc4cn[nH]c4)cc3n2C1 CHEMBL3938307 IC50 145.0 nM
Cc1cc(NC(=O)c2ccc3cc4n(c3c2)CC2(CC2)CNC4=O)no1 CHEMBL3927200 IC50 145.0 nM
N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL1789941 Kd 150.0 nM
CC(C)(C)c1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)no1 CHEMBL3966062 IC50 150.0 nM
Cc1cc(NC(=O)c2ccc3cc4n(c3c2)CC(C)CNC4=O)no1 CHEMBL3896482 IC50 150.0 nM
CNC(=O)c1ccccc1NC(=O)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3983084 IC50 154.0 nM
O=C(Nc1cc(-c2ccc(F)cc2)on1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3981997 IC50 155.0 nM
Cc1cc(NC(=O)c2ccc3cc4n(c3c2)[C@@H](C)[C@H](C)NC4=O)no1 CHEMBL3954110 IC50 160.0 nM
CC(=O)c1cccc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)c1 CHEMBL3983605 IC50 160.0 nM
Cc1cccc(-c2cc(NC(=O)c3ccc4cc5n(c4c3)CCCNC5=O)on2)c1 CHEMBL3941595 IC50 160.0 nM
Cn1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2ccc(Cl)cc21 CHEMBL3909410 IC50 170.0 nM
O=C(Nc1ccc2scnc2c1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3947149 IC50 180.0 nM
O=C(Nc1ccc(Cl)cc1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938782 IC50 190.0 nM
COc1cccc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)c1 CHEMBL3975596 IC50 190.0 nM
COc1cc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)cc(OC)c1 CHEMBL3297947 IC50 210.0 nM
Cn1cc(C2=C(c3cn(C4CCN(Cc5ccccn5)CC4)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL300138 Kd 220.0 nM
COc1ccc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)cc1N CHEMBL3297950 IC50 220.0 nM
COc1cc(Nc2nc3cccc(-c4ccccc4F)c3o2)cc(OC)c1OC CHEMBL3298040 IC50 220.0 nM
O=C(Nc1ccn(Cc2ccc(F)cc2)n1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3952432 IC50 220.0 nM
O=C(Nc1ccccn1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938788 IC50 220.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 240.0 nM
CC(C)(C)c1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)sn1 CHEMBL3912005 IC50 240.0 nM
C[C@H]1CNC(=O)c2cc3ccc(C(=O)Nc4cccnc4)cc3n2[C@H]1C CHEMBL3967109 IC50 240.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 260.0 nM
O=C(Nc1cccc(Cl)c1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938783 IC50 270.0 nM
Cc1nc2cc(NC(=O)c3ccc4cc5n(c4c3)CCCNC5=O)ccc2s1 CHEMBL3910980 IC50 270.0 nM
CN(C)C[C@@H]1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1 CHEMBL91829 Kd 280.0 nM
O=C(Nc1ccccc1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938781 IC50 290.0 nM
O=C(Nc1cc(-c2ccccc2)on1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3897006 IC50 290.0 nM
Cc1cnc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)s1 CHEMBL3955674 IC50 300.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 Kd 310.0 nM
Cn1cc(NC(=O)c2ccc3cc4n(c3c2)CC2(CCC2)CNC4=O)cn1 CHEMBL3958165 IC50 320.0 nM
Cn1cc(NC(=O)c2ccc3cc4n(c3c2)CC(C)(C)CNC4=O)cn1 CHEMBL3939161 IC50 335.0 nM
COc1cccc(F)c1-c1cccc2nc(Nc3cccc(S(N)(=O)=O)c3)oc12 CHEMBL3297949 IC50 340.0 nM
O=C(Nc1cnn(Cc2ccccc2)c1)c1ccc2cc3n(c2c1)CC1(CCNCC1)CNC3=O CHEMBL3976641 IC50 350.0 nM
O=C(Nc1nc2ccccc2o1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938802 IC50 370.0 nM
COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(S(C)(=O)=O)CC2)nc1N CHEMBL384304 Kd 390.0 nM
COc1ccccc1NC(=O)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938785 IC50 400.0 nM
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=O)c1c(F)cccc1F CHEMBL191003 Kd 410.0 nM
COc1cccc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)c1 CHEMBL3297840 IC50 410.0 nM
O=C(Nc1cccnc1)c1ccc2cc3n(c2c1)CC1(CC1)CNC3=O CHEMBL1938770 IC50 430.0 nM
COc1ccc(NCN2C(=O)c3ccccc3C2=O)cc1 CHEMBL3781731 IC50 470.0 nM
CCOc1cccc(F)c1-c1cccc2nc(Nc3cc(OC)c(OC)c(OC)c3)oc12 CHEMBL3298042 IC50 490.0 nM
Cc1cc(NC(=O)c2ccc3cc4n(c3c2)[C@@H](C)CNC4=O)no1 CHEMBL3971944 IC50 495.0 nM
Cn1c(-c2ccccc2)cnc1NC(=O)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3919152 IC50 500.0 nM
O=C1c2ccccc2C(=O)N1CNc1ccc(O)cc1 CHEMBL3779994 IC50 520.0 nM
Cn1ccc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)n1 CHEMBL1938795 IC50 540.0 nM
CN(C)CCCn1c(NC(=O)c2ccc3cc4n(c3c2)CC2(CCNCC2)CNC4=O)nc2ccccc21 CHEMBL3897126 IC50 540.0 nM
COc1cc(Nc2nc3cccc(-c4nc(C)[nH]c4C)c3o2)cc(OC)c1OC CHEMBL3298192 IC50 560.0 nM
Cc1cc(NC(=O)c2ccc3cc4n(c3c2)[C@@H](C)[C@H](C)CNC4=O)no1 CHEMBL4108195 IC50 570.0 nM
COc1ccc(NCN2C(=O)c3ccc(N)cc3C2=O)cc1 CHEMBL3780594 IC50 590.0 nM
CCOc1ccc(NCN2C(=O)c3ccccc3C2=O)cc1 CHEMBL3780949 IC50 590.0 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL221959 Kd 600.0 nM
C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)c1ncnc2[nH]ccc12 CHEMBL2103743 Kd 600.0 nM
CC(C)(CO)n1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2ccccc21 CHEMBL3896578 IC50 610.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 620.0 nM
COc1cccc(F)c1-c1cccc2nc(NC3CCCCC3)oc12 CHEMBL3297843 IC50 620.0 nM
COc1cccc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)n1 CHEMBL3297845 IC50 620.0 nM
Cc1cc(NC(=O)c2ccc3cc4n(c3c2)CC(F)(F)CNC4=O)no1 CHEMBL3927732 IC50 670.0 nM
CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc2N1C1CCCC1 CHEMBL513909 Kd 700.0 nM
CCOc1cccc(Nc2nc3cccc(-c4c(F)cccc4OC)c3o2)c1 CHEMBL3297846 IC50 730.0 nM
O=C1c2ccccc2C(=O)N1CNc1ccc(N2CCOCC2)cc1 CHEMBL1775068 IC50 790.0 nM
CN(C)c1nc2ccc1CCCn1cc(c3ccccc31)C1=C(C(=O)NC1=O)c1cn(c3ccccc13)CC2 CHEMBL1162963 IC50 850.0 nM
CCN(CC)c1ccc(NCN2C(=O)c3ccccc3C2=O)c(C)c1 CHEMBL3781117 IC50 860.0 nM
O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)ccc12 CHEMBL31574 IC50 891.0 nM
C[C@@H]1NC(=O)c2cc3ccc(C(=O)Nc4cccnc4)cc3n2[C@H]1C CHEMBL3968696 IC50 895.0 nM
O=C(Nc1cccc(Oc2ccccc2)c1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL3948994 IC50 900.0 nM
O=C(Nc1cnn(Cc2ccccc2)c1)c1ccc2cc3n(c2c1)CC1(CCOCC1)CNC3=O CHEMBL3973806 IC50 900.0 nM
CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(-c3c[nH]c4ncccc34)cs2)c1 CHEMBL4249925 Ki 940.0 nM
COc1cc(Nc2nc3cccc(-c4c(F)cccc4OC(C)C)c3o2)cc(OC)c1OC CHEMBL3298043 IC50 970.0 nM
COc1ccc(NCN2C(=O)c3cccc(NC(=O)c4ccccc4)c3C2=O)cc1 CHEMBL3780363 IC50 990.0 nM
COc1cccc(F)c1-c1cccc2nc(Nc3ccccc3)oc12 CHEMBL3297842 IC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM