CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.0795 nM
C[C@@H]1CNC(=O)c2cc3ccc(C(=O)Nc4cnn(Cc5ccccc5)c4)nc3n21 CHEMBL3673622 IC50 0.2 nM
CC1CCNC(=O)c2cc3ccc(C(=O)Nc4cnn(Cc5ccncc5)c4)nc3n21 CHEMBL3673631 IC50 0.27 nM
CN1CCN(c2ccc(-c3c(-c4cc(F)c(O)c(F)c4)cnc4[nH]ccc34)cc2)CC1 CHEMBL4292020 IC50 0.3 nM
C[C@H]1NC(=O)c2cc3ccc(C(=O)Nc4cnn(Cc5ccccc5)c4)nc3n2[C@H]1C CHEMBL3673624 IC50 0.34 nM
CC1CCNC(=O)c2cc3ccc(C(=O)Nc4cnn(Cc5ccccc5)c4)nc3n21 CHEMBL3673609 IC50 0.39 nM
CN(C1COC1)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21 CHEMBL3702836 Kd 0.54 nM
CC1CCNC(=O)c2cc3ccc(C(=O)Nc4cnn(C)c4)nc3n21 CHEMBL3673603 IC50 0.78 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 IC50 1.0 nM
CCn1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2ccccc21 CHEMBL1933280 IC50 1.0 nM
C[C@@H]1CCNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n21 CHEMBL1933288 IC50 1.0 nM
Cn1cc(Nc2ncc(Br)c(Nc3ccccc3C(N)=O)n2)cn1 CHEMBL1994669 pKi 1.0 nM
CC1CCNC(=O)c2cc3ccc(C(=O)Nc4cnn(C(C)(C)C)c4)nc3n21 CHEMBL3673606 IC50 1.1 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 1.585 nM
O=C1Nc2ccccc2/C1=C/c1c[nH]nc1-c1ccccc1[N+](=O)[O-] CHEMBL2347053 IC50 1.6 nM
CC1CCNC(=O)c2cc3ccc(C(=O)Nc4cnc5c(cnn5CC5CCOC5)c4)nc3n21 CHEMBL3673598 IC50 1.6 nM
Cn1cc(NC(=O)c2ccc3cc4n(c3n2)CCCNC4=O)nc1C(=O)NC1CCCC1 CHEMBL3639725 IC50 1.6 nM
O=C(Nc1cnn(Cc2ccncc2)c1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1933278 IC50 2.0 nM
Oc1c(F)cc(-c2cnc3[nH]ccc3c2-c2ccc(N3CCOCC3)cc2)cc1F CHEMBL4278817 IC50 2.0 nM
Cc1ccc(-c2c(-c3cc(F)c(O)c(F)c3)cnc3[nH]ccc23)cc1 CHEMBL4289492 IC50 2.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 2.0 nM
CC(C)n1ncc2cc(NC(=O)c3ccc4cc5n(c4n3)C(C)CCNC5=O)cnc21 CHEMBL3673592 IC50 2.1 nM
NC(=O)c1ccccc1NC(=O)c1ccc2cc3n(c2n1)CCCNC3=O CHEMBL3673589 IC50 2.3 nM
CC1CCNC(=O)c2cc3ccc(C(=O)Nc4cnc5c(cnn5C5CCOCC5)c4)nc3n21 CHEMBL3673595 IC50 2.3 nM
Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCC#N)c4c21)CNC3=O CHEMBL302449 pKi 2.512 nM
Cc1cc(NC(=O)c2ccc3cc4n(c3n2)[C@@H](C)[C@@H](C)NC4=O)no1 CHEMBL3673648 IC50 2.6 nM
CCN1CCC(Nc2ccc3c(c2)C(=C(c2ccc(Cl)cc2)c2ncc[nH]2)C(=O)N3)CC1 CHEMBL2086760 IC50 3.0 nM
C[C@@H]1NC(=O)c2cc3ccc(C(=O)Nc4cnn(Cc5ccccc5)c4)nc3n2[C@H]1C CHEMBL3673625 IC50 3.0 nM
C[C@@H]1CNC(=O)c2cc3ccc(C(=O)Nc4cnc5ccccc5c4)nc3n21 CHEMBL3673627 IC50 3.0 nM
CC1CCNC(=O)c2cc3ccc(C(=O)Nc4cc(Cc5ccccc5)on4)nc3n21 CHEMBL3673657 IC50 3.3 nM
O=C(Nc1cc(Cc2ccccc2)no1)c1ccc2cc3n(c2n1)CCCNC3=O CHEMBL3673658 IC50 3.6 nM
Cc1ccnc(NC(=O)c2ccc3cc4n(c3n2)CCCNC4=O)c1 CHEMBL3673601 IC50 3.8 nM
O=C(Nc1cnn(Cc2ccccc2)c1)c1ccc2cc3n(c2n1)CCCNC3=O CHEMBL3673610 IC50 3.8 nM
C[C@@H]1CNC(=O)c2cc3ccc(C(=O)Nc4cc(Cc5ccccc5)on4)nc3n21 CHEMBL3673661 IC50 3.9 nM
CCn1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2cccnc21 CHEMBL1933287 IC50 4.0 nM
O=C(Nc1nc2ccccc2[nH]1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938803 IC50 4.0 nM
Cc1ccc(-c2c(/C=C(\C#N)C(=O)NC(C)(C)C)n(CCCO)c3ncnc(N)c23)cc1 CHEMBL2216829 IC50 4.0 nM
CC(C)CCN1c2nc(Nc3cc(F)c(O)c(F)c3)ncc2N(C)C(=O)[C@H]1C CHEMBL3604889 IC50 4.0 nM
Oc1c(F)cc(-c2cnccc2-c2ccc(N3CCOCC3)cc2)cc1F CHEMBL3604794 IC50 4.0 nM
CN1CCN(c2cccc(-c3ccncc3-c3cc(F)c(O)c(F)c3)c2)CC1 CHEMBL3604787 IC50 4.0 nM
NCCOc1cccc(-c2ccncc2-c2cc(F)c(O)c(F)c2)c1 CHEMBL3604784 IC50 4.0 nM
CC(C)n1ncc2cc(NC(=O)c3ccc4cc5n(c4n3)[C@H](C)CNC5=O)cnc21 CHEMBL3673629 IC50 4.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 4.0 nM
CC(C)CCN1c2nc(Nc3cc(F)c(O)c(F)c3)ncc2N(C)C(=O)C1C CHEMBL573107 IC50 4.0 nM
CN1CCN(c2ccc(-c3ccncc3-c3cc(F)c(O)c(F)c3)cc2)CC1 CHEMBL3604793 IC50 4.0 nM
CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL4116008 IC50 4.0 nM
O=C(Nc1cc(-c2ccccc2)no1)c1ccc2cc3n(c2n1)CCCNC3=O CHEMBL3673644 IC50 4.3 nM
CC(C)n1c(NC(=O)c2ccc3nc4n(c3c2)C(C)(C)CCNC4=O)nc2ccccc21 CHEMBL3673581 IC50 4.7 nM
Cn1cc(NC(=O)c2ccc3cc4n(c3n2)CCCNC4=O)cn1 CHEMBL3673604 IC50 4.8 nM
Oc1c(F)cc(-c2cnccc2-c2cccc(-c3cn[nH]c3)c2)cc1F CHEMBL3604785 IC50 5.0 nM
Cc1ccc(-c2c(/C=C(\C#N)C(=O)NC(C)C)n(CCCO)c3ncnc(N)c23)cc1 CHEMBL4089765 IC50 5.0 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccc[nH]2)C(=O)N3)c1)Cc1ccccc1 CHEMBL1980407 pKi 5.012 nM
NC1CCC(Nc2nccc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1966628 pKi 5.012 nM
NCCC(C(=O)Nc1ccc2[nH]ncc2c1)c1ccc(Cl)c(Cl)c1 CHEMBL1998121 pKi 5.012 nM
C[C@H]1NC(=O)c2cc3ccc(C(=O)Nc4cc(Cc5ccccc5)on4)nc3n2[C@H]1C CHEMBL3673662 IC50 5.1 nM
Cc1cc(NC(=O)c2ccc3cc4n(c3n2)C(C)CCNC4=O)no1 CHEMBL3673645 IC50 5.2 nM
CCn1c(NC(=O)c2ccc3nc4n(c3c2)CCCNC4=O)nc2ccccc21 CHEMBL3673567 IC50 5.5 nM
CCn1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2cc(Cl)ccc21 CHEMBL1933284 IC50 6.0 nM
Cc1ccc(Nc2cc(-c3ccc(N4CCN(C)CC4)cc3)c(-c3cc(F)c(O)c(F)c3)cn2)cc1 CHEMBL3604884 IC50 6.0 nM
CN1CCN(c2ccc(-c3cc(N)ncc3-c3cc(F)c(O)c(F)c3)cc2)CC1 CHEMBL3604881 IC50 6.0 nM
Oc1c(F)cc(-c2cnccc2-c2ccc(N3CCNCC3)cc2)cc1F CHEMBL3604792 IC50 6.0 nM
Oc1ccc(-c2cn[nH]c2-c2cc(F)c(O)c(F)c2)cc1 CHEMBL3604775 IC50 6.0 nM
O=C(Nc1nc2cc(Cl)ccc2[nH]1)c1ccc2cc3n(c2n1)CCCNC3=O CHEMBL3673630 IC50 6.1 nM
Cc1cc(NC(=O)c2ccc3cc4n(c3n2)[C@H](C)CNC4=O)no1 CHEMBL3673647 IC50 6.6 nM
O=C(Nc1nc2cc(Cl)cc(CN3CCOCC3)c2[nH]1)c1ccc2cc3n(c2n1)CCCNC3=O CHEMBL3673612 IC50 6.7 nM
O=C(Nc1cnn(CC2CCCCC2)c1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1933149 IC50 7.0 nM
Cc1ccc(-c2ccncc2-c2cc(F)c(O)c(F)c2)cc1 CHEMBL3604789 IC50 7.0 nM
Cc1ccc(-c2c(/C=C(\C#N)C(=O)OC(C)(C)C)n(CCCO)c3ncnc(N)c23)cc1 CHEMBL4061650 IC50 7.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(OC(F)(F)F)c4)c3)cc12 CHEMBL1965836 pKi 7.943 nM
N#Cc1ncc2nc1OCCCCCOc1cc(CCCO)c(Cl)cc1NC(=O)N2 CHEMBL223367 pKi 7.943 nM
N#Cc1ncc2nc1OCCCCCOc1cc(OCCO)c(Cl)cc1NC(=O)N2 CHEMBL413779 pKi 7.943 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL1970903 pKi 7.943 nM
COc1ccc(-c2ccncc2-c2cc(F)c(O)c(F)c2)cc1 CHEMBL3604790 IC50 8.0 nM
Cn1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2ccccc21 CHEMBL1933279 IC50 9.0 nM
O=C(Nc1cnc2ccccc2c1)c1ccc2cc3n(c2n1)CCCNC3=O CHEMBL3673586 IC50 9.2 nM
CC(C)(C)n1cc(NC(=O)c2ccc3cc4n(c3n2)CCCNC4=O)cn1 CHEMBL3673607 IC50 9.7 nM
Cn1cc(C2=C(c3cn(CCCSC(=N)N)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL6291 IC50 10.0 nM
O=C(Nc1cnn(Cc2ccccn2)c1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1933277 IC50 10.0 nM
NC(COc1cncc(-c2ccc3c(c2)CC(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL1967302 pKi 10.0 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 10.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 pKi 10.0 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 10.0 nM
Cc1ccc(-c2nc(N)ncc2-c2cc(F)c(O)c(F)c2)cc1 CHEMBL3604885 IC50 10.0 nM
Cn1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)cn1 CHEMBL1933148 IC50 11.0 nM
CCn1c(NC(=O)c2ccc3cc4n(c3n2)[C@@H](C)[C@@H](C)NC4=O)nc2ccccc21 CHEMBL3673636 IC50 11.6 nM
CCn1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2ccc(Cl)cc21 CHEMBL1933285 IC50 12.0 nM
CC1(C)CNC(=O)c2cc3ccc(C(=O)Nc4cnn(Cc5ccccc5)c4)nc3n2C1 CHEMBL3673611 IC50 12.0 nM
C[C@H]1CNC(=O)c2cc3ccc(C(=O)Nc4cnn(Cc5ccccc5)c4)nc3n21 CHEMBL3673623 IC50 12.0 nM
CN(C)CCCn1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2ccccc21 CHEMBL1933283 IC50 12.0 nM
NC(COc1cncc(-c2ccc3[nH]c(=O)oc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL1987679 pKi 12.59 nM
N#Cc1ncc2nc1OCCCCCOc1cc(OCCCO)c(Cl)cc1NC(=O)N2 CHEMBL373598 pKi 12.59 nM
NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1973720 pKi 12.59 nM
O=C(Nc1cc(Cc2ccccc2)no1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1933147 IC50 13.0 nM
COc1c(Nc2ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)ccc2c1CC[C@@H](N1CCOCC1)CC2 CHEMBL2064666 IC50 13.0 nM
CNc1ncc(-c2cc(F)c(O)c(F)c2)c(-c2ccc(C)cc2)n1 CHEMBL3604886 IC50 13.0 nM
O=C(Nc1cnc2c(cnn2CC2CCOC2)c1)c1ccc2cc3n(c2n1)CCCNC3=O CHEMBL3673599 IC50 13.0 nM
CC1CCNC(=O)c2cc3ccc(C(=O)Nc4cc(Cc5ccccc5)no4)nc3n21 CHEMBL3673659 IC50 13.0 nM
C[C@H]1CCNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n21 CHEMBL1933289 IC50 14.0 nM
CNc1cc(-c2ccc(N3CCN(C)CC3)cc2)c(-c2cc(F)c(O)c(F)c2)cn1 CHEMBL3604882 IC50 14.0 nM
Cc1ccc(-c2c(C(=O)CF)n(CCCO)c3ncnc(N)c23)cc1 CHEMBL515414 IC50 15.0 nM
CCn1c(NC(=O)c2ccc3cc4n(c3n2)C(C)CCNC4=O)nc2ccccc21 CHEMBL3673632 IC50 15.0 nM
Cc1ccc(-c2c(C(=O)CCl)n(CCCO)c3ncnc(N)c23)cc1 CHEMBL515416 IC50 15.0 nM
COC(=O)CCc1ccc(-n2cnc3cnc(Nc4cc(F)c(O)c(F)c4)nc32)cc1 CHEMBL4878141 IC50 15.7 nM
Cc1n[nH]c2cnc(-c3cncc(OCC(N)Cc4cccc(C(F)(F)F)c4)c3)cc12 CHEMBL1998159 pKi 15.85 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 15.85 nM
Oc1ccc(Nc2[nH]nc(-c3ccc(O)cc3)c2-c2ccc(O)cc2)cc1 CHEMBL1969042 pKi 15.85 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccc(Cl)c(Cl)c4)c3)cc12 CHEMBL1991063 pKi 15.85 nM
O=C(Nc1cccc(-c2c[nH]cn2)c1)c1ccc2cc3n(c2n1)CCCNC3=O CHEMBL3673667 IC50 17.0 nM
COC(=O)CCCc1ccc(-n2cnc3cnc(Nc4cc(F)c(O)c(F)c4)nc32)cc1 CHEMBL4851452 IC50 17.8 nM
O=C(Nc1cc(C2CC2)no1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1933068 IC50 18.0 nM
Oc1c(F)cc(-c2cnccc2-c2cccc(N3CCOCC3)c2)cc1F CHEMBL3604786 IC50 18.0 nM
Oc1c(F)cc(Nc2ncc3ncn(-c4ccc(CCN5CCOCC5)cc4)c3n2)cc1F CHEMBL4849660 IC50 18.4 nM
Cc1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)on1 CHEMBL1933143 IC50 19.0 nM
CC(C)(C)c1cc(NC(=O)c2ccc3cc4n(c3n2)CCCNC4=O)no1 CHEMBL3673642 IC50 19.0 nM
Cc1cc(NC(=O)c2ccc3cc4n(c3n2)CCCNC4=O)no1 CHEMBL3673643 IC50 19.0 nM
CN(C)CC1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1 CHEMBL360847 pKi 19.95 nM
Cc1ccc(-c2c(C(=O)CF)n(CCCNCC#N)c3ncnc(N)c23)cc1 CHEMBL1221698 IC50 20.0 nM
CC(C)n1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2ccccc21 CHEMBL1933281 IC50 20.0 nM
CN(C)CCCn1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2ccc(Cl)cc21 CHEMBL1933286 IC50 20.0 nM
CCC[C@@H]1O[C@@H](Oc2c(-c3ccc(O)cc3)oc3cc(O)cc(O)c3c2=O)[C@H](O)[C@H](OC(C)=O)[C@H]1OC(C)=O CHEMBL2321925 IC50 20.0 nM
CC(C)Nc1ncc(-c2cc(F)c(O)c(F)c2)c(-c2ccc(N3CCN(C)CC3)cc2)n1 CHEMBL3604888 IC50 20.0 nM
CNC(=O)c1ccc(-c2ccncc2-c2cc(F)c(O)c(F)c2)cc1 CHEMBL3604791 IC50 20.0 nM
O=C(Nc1cccc(F)c1)c1ccc2cc3n(c2n1)CCCNC3=O CHEMBL3673588 IC50 20.0 nM
O=C(Nc1cnc2c(cnn2C2CCOCC2)c1)c1ccc2cc3n(c2n1)CCCNC3=O CHEMBL3673596 IC50 20.0 nM
Oc1ccc(-c2cn[nH]c2-c2ccc(O)cc2)cc1 CHEMBL3604771 IC50 20.0 nM
NC(=O)c1ccccc1NC(=O)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938786 IC50 21.0 nM
CC(C)CNc1cc(-c2ccc(N3CCN(C)CC3)cc2)c(-c2cc(F)c(O)c(F)c2)cn1 CHEMBL3604883 IC50 22.0 nM
Cc1ccc(-c2nc(NC(C)C)ncc2-c2cc(F)c(O)c(F)c2)cc1 CHEMBL3604887 IC50 23.0 nM
CCn1c(NC(=O)c2ccc3nc4n(c3c2)CCCNC4=O)nc2cccnc21 CHEMBL3673580 IC50 23.0 nM
Cc1c(NCCN(C)C)cc(Cl)cc1N1CCN(c2ncnc3[nH]nc(C(F)(F)F)c23)CC1 CHEMBL2012703 IC50 24.0 nM
Oc1c(F)cc(Nc2ncc3ncn(-c4ccc(N5CCOCC5)cc4)c3n2)cc1F CHEMBL4858455 IC50 24.6 nM
CC(C)n1ncc2cc(NC(=O)c3ccc4cc5n(c4n3)CCCNC5=O)cnc21 CHEMBL3673593 IC50 25.0 nM
CC1(C)CNC(=O)c2cc3ccc(C(=O)Nc4cnc5c(cnn5CC5CCOC5)c4)nc3n2C1 CHEMBL3673600 IC50 25.0 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 25.12 nM
CS(=O)(=O)Nc1cc2c(cc1Cl)NC(=O)Nc1cnc(C#N)c(n1)OCCCCCO2 CHEMBL223460 pKi 25.12 nM
NC(COc1cncc(-c2cc3ccncc3s2)c1)Cc1c[nH]c2ccccc12 CHEMBL1966524 pKi 25.12 nM
Oc1c(F)cc(Nc2ncc3ccn(-c4ccc(N5CCOCC5)cc4)c3n2)cc1F CHEMBL4857399 IC50 25.7 nM
CC(C)c1cc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)on1 CHEMBL1933145 IC50 26.0 nM
O=C(Nc1ncc[nH]1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938792 IC50 26.0 nM
CCn1c(NC(=O)c2ccc3cc4n(c3n2)[C@H](C)CNC4=O)nc2ccccc21 CHEMBL3673635 IC50 26.5 nM
CN(C)CCCn1c(NC(=O)c2ccc3cc4n(c3c2)CC(C)(C)CNC4=O)nc2ccccc21 CHEMBL1933290 IC50 27.0 nM
CC1CCNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)nc3n21 CHEMBL3673633 IC50 27.0 nM
C[C@H]1NC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)nc3n2[C@H]1C CHEMBL3673640 IC50 29.0 nM
O=C1Nc2cc(-c3ccc(O)cc3)ccc2C1=Cc1ccc[nH]1 CHEMBL1980329 pKi 31.62 nM
Cc1cccc(-c2ccncc2-c2cc(F)c(O)c(F)c2)c1 CHEMBL3604782 IC50 32.0 nM
CC(C)n1c(NC(=O)c2ccc3nc4n(c3c2)CCCNC4=O)nc2ccccc21 CHEMBL3639724 IC50 33.0 nM
O=C(Nc1ccncc1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938787 IC50 34.0 nM
O=C(Nc1cnc2ccccc2c1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938798 IC50 34.0 nM
C[C@H]1CNC(=O)c2cc3ccc(C(=O)Nc4cnc5ccccc5c4)nc3n21 CHEMBL3673628 IC50 34.0 nM
CN1CCN(c2ccc(-n3ccc4cnc(Nc5cc(F)c(O)c(F)c5)nc43)cc2)CC1 CHEMBL4864190 IC50 34.7 nM
Cn1c(NC(=O)c2ccc3nc4n(c3c2)CCCNC4=O)nc2ccccc21 CHEMBL3673566 IC50 35.0 nM
O=C(Nc1cccnc1)c1ccc2cc3n(c2n1)CCCNC3=O CHEMBL3673590 IC50 37.0 nM
CN1CCN(c2ccc(-c3c(-c4cc(F)cc(F)c4)cnc4[nH]ccc34)cc2)CC1 CHEMBL4284142 IC50 38.0 nM
CCn1c(-c2nonc2N)nc2cnc(Oc3cccc(NC(=O)c4ccc(OCCN5CCOCC5)cc4)c3)cc21 CHEMBL220241 pKi 39.81 nM
CCn1c(-c2nonc2N)nc2cncc(C(=O)N3CCC(N)C3)c21 CHEMBL1870106 pKi 39.81 nM
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1973540 pKi 39.81 nM
O=c1c(NCc2ccc(Cl)cc2Cl)c(Nc2ccc3[nH]ncc3c2)c1=O CHEMBL1979554 pKi 39.81 nM
CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1 CHEMBL2006765 pKi 39.81 nM
CC1CCNC(=O)c2cc3ccc(C(=O)Nc4cccnc4)cc3n21 CHEMBL1938765 IC50 41.0 nM
O=C(Nc1cn[nH]c1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938794 IC50 43.0 nM
CC1(C)CNC(=O)c2cc3ccc(C(=O)Nc4cc(C5CC5)on4)nc3n2C1 CHEMBL3673653 IC50 43.0 nM
O=C(Nc1cnn(Cc2ccccc2)c1)c1ccc2nc3n(c2c1)CCCNC3=O CHEMBL3673569 IC50 44.0 nM
C[C@@H]1NC(=O)c2cc3ccc(C(=O)Nc4cccnc4)cc3n2[C@@H]1C CHEMBL1938776 IC50 45.0 nM
CCn1c(NC(=O)c2ccc3nc4n(c3c2)CCCNC4=O)nc2ccc(Cl)nc21 CHEMBL3673578 IC50 45.0 nM
COc1cccc(-c2ccncc2-c2cc(F)c(O)c(F)c2)c1 CHEMBL3604783 IC50 46.0 nM
Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cc(Cl)cnc12 CHEMBL4552628 IC50 47.0 nM
CN(C)c1nc2ccc1CCCn1cc(c3ccccc31)C1=C(C(=O)NC1=O)c1cn(c3ccccc13)CC2 CHEMBL1162963 IC50 48.0 nM
Oc1ccc(-c2ccncc2-c2cc(F)c(O)c(F)c2)cc1 CHEMBL3604777 IC50 50.0 nM
CC1(C)CNC(=O)c2cc3ccc(C(=O)Nc4cnn(C(C)(C)C)c4)nc3n2C1 CHEMBL3673608 IC50 50.0 nM
O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c1nc(N2CCNCC2)nc2ccccc12 CHEMBL1996510 pKi 50.12 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1Cl CHEMBL1965660 pKi 50.12 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 50.12 nM
N#Cc1ncc2nc1OCCCCCOc1cc(OCC(O)CO)c(Cl)cc1NC(=O)N2 CHEMBL223257 pKi 50.12 nM
O=C(Nc1cccc(-c2c[nH]cn2)c1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938791 IC50 52.0 nM
CCc1ccccc1C(=O)Nc1n[nH]c2c(C)c(F)c(C3C(C#N)=C(C)N(C)C(C)=C3C#N)cc12 CHEMBL4580220 IC50 52.0 nM
CC(C)n1ncc2cc(NC(=O)c3ccc4cc5n(c4c3)CCCNC5=O)cnc21 CHEMBL1938799 IC50 53.0 nM
Nc1n[nH]c(-c2ccc(O)cc2)c1-c1ccccc1 CHEMBL3604774 IC50 53.0 nM
C[C@@H]1CNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)nc3n21 CHEMBL3673639 IC50 54.0 nM
CCn1c(NC(=O)c2ccc3cc4n(c3n2)[C@@H](C)CNC4=O)nc2ccccc21 CHEMBL3673634 IC50 54.5 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 55.0 nM
CC1(C)CNC(=O)c2cc3ccc(C(=O)Nc4nc5cc(Cl)ccc5[nH]4)nc3n2C1 CHEMBL3673613 IC50 55.0 nM
CC(C)CCn1cnc2cnc(Nc3cc(F)c(O)c(F)c3)nc21 CHEMBL4858257 IC50 55.5 nM
Cc1nc(-c2cccc(NC(=O)c3ccc4cc5n(c4n3)CCCNC5=O)c2)cs1 CHEMBL3673587 IC50 56.0 nM
C[C@@H]1NC(=O)c2cc3ccc(C(=O)Nc4cc(Cc5ccccc5)on4)nc3n2[C@H]1C CHEMBL3673663 IC50 57.0 nM
Oc1c(F)cc(-c2cnccc2-c2ccccc2)cc1F CHEMBL3604778 IC50 60.0 nM
O=C(Nc1nc2ccccc2n1-c1ccccc1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1933282 IC50 61.0 nM
CC1(C)CNC(=O)c2cc3ccc(C(=O)Nc4cnc5c(cnn5C5CCOCC5)c4)nc3n2C1 CHEMBL3673597 IC50 62.0 nM
CN(C)C1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1969151 pKi 63.1 nM
COc1cccc(C(C)NC(=O)N2CC=C(c3c[nH]c4ncccc34)CC2)c1 CHEMBL1965845 pKi 63.1 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 65.0 nM
O=C(Nc1ccc2ccccc2n1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938800 IC50 68.0 nM
CCc1n[nH]c2ncnc(N3CCN(c4cc(Cl)cc(NCCN(C)C)c4C)CC3)c12 CHEMBL2012701 IC50 68.0 nM
Cn1cc(NC(=O)c2ccc3nc4n(c3c2)CCCNC4=O)nc1C(=O)NC1CCCC1 CHEMBL3673573 IC50 69.0 nM
Cn1cc(NC(=O)c2ccc3cc4n(c3n2)CC(C)(C)CNC4=O)cn1 CHEMBL3673605 IC50 72.0 nM
CCc1cccc(NC(=O)Nc2ccc3c(c2)CCc2sc4ncnc(N)c4c2-3)c1 CHEMBL1968406 pKi 79.43 nM
OC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1991674 pKi 79.43 nM
Oc1cccc(-n2cnc3cnc(Nc4cc(F)c(O)c(F)c4)nc32)c1 CHEMBL4861235 IC50 79.8 nM
COc1ccc(-c2ccncc2-c2cc(F)c(O)c(F)c2)cn1 CHEMBL3604795 IC50 80.0 nM
CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]c(F)c(c3c2)-c2cn(nc2C(F)(F)F)CCCC1=O CHEMBL5086263 IC50 80.0 nM
Oc1ccc(-n2cnc3cnc(Nc4cc(F)c(O)c(F)c4)nc32)cc1 CHEMBL4865383 IC50 81.8 nM
CC(C)n1ncc2cc(NC(=O)c3ccc4cc5n(c4n3)[C@@H](C)CNC5=O)cnc21 CHEMBL3673626 IC50 84.0 nM
O=C(Nc1cc(-c2ccccc2)no1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1933146 IC50 86.0 nM
Cn1cc(C2=C(c3cn(C4CCN(Cc5ccccn5)CC4)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL300138 Kd 87.0 nM
CC(=O)O[C@@H]1[C@@H](OC(C)=O)[C@@H](O)[C@H](Oc2c(-c3ccc(O)cc3)oc3cc(O)cc(O)c3c2=O)O[C@H]1C CHEMBL240954 IC50 89.0 nM
CCOC(=O)c1nc(NC(=O)c2ccc3cc4n(c3n2)CCCNC4=O)cn1C CHEMBL3673591 IC50 90.0 nM
CC1(C)CNC(=O)c2cc3ccc(C(=O)Nc4cnc5ccccc5c4)nc3n2C1 CHEMBL3673602 IC50 91.0 nM
CN(C)CCCn1c(NC(=O)c2ccc3nc4n(c3c2)CCCNC4=O)nc2ccccc21 CHEMBL3673579 IC50 92.0 nM
O=C(Nc1cc[nH]n1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938796 IC50 93.0 nM
Oc1c(F)cc(-c2cnccc2-c2ccc(F)cc2)cc1F CHEMBL3604788 IC50 94.0 nM
CC(C)CCn1ccc2cnc(Nc3cc(F)c(O)c(F)c3)nc21 CHEMBL4873445 IC50 95.8 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 100.0 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 100.0 nM
CCCCN(CCC#N)C(=O)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1983348 pKi 100.0 nM
CCN1CCN(c2ccc(Nc3ncc(C#N)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1973516 pKi 100.0 nM
c1ccc(CNc2nc(Nc3cc(C4CC4)[nH]n3)c3sccc3n2)cc1 CHEMBL1997924 pKi 100.0 nM
CCN(C(C)=O)c1ccc(Nc2nc(NC3CC3)c3nc[nH]c3n2)cc1 CHEMBL2006564 pKi 100.0 nM
CC(=NNC(=N)N)c1cc(NC(=O)c2cccc(C(=O)Nc3cc(C(C)=NNC(=N)N)cc(C(C)=NNC(=N)N)c3)c2)cc(C(C)=NNC(=N)N)c1 CHEMBL2000685 pKi 100.0 nM
COCc1nnn(-c2nonc2N)c1C(=O)NN=C(C)c1ccc(O)cc1O CHEMBL1991180 pKi 100.0 nM
Cc1cc(OC2CCCC2)c(NC(=O)Nc2cnc(C#N)cn2)cc1Cl CHEMBL2001224 pKi 100.0 nM
Cc1nc(Nc2n[nH]c3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)c2sccc2n1 CHEMBL3128043 Kd apparent 100.0 nM
CC(C)n1ncc2cc(NC(=O)c3ccc4cc5n(c4n3)CC(C)(C)CNC5=O)cnc21 CHEMBL3673594 IC50 105.0 nM
CCc1cc(NC(=O)c2ccc3cc4n(c3n2)CC(C)(C)CNC4=O)no1 CHEMBL3673651 IC50 109.0 nM
Cc1cc(NC(=O)c2ccc3cc4n(c3n2)[C@@H](C)[C@H](C)NC4=O)no1 CHEMBL3673649 IC50 110.0 nM
CC1CNC(=O)c2cc3ccc(C(=O)Nc4cccnc4)nc3n21 CHEMBL3673664 IC50 120.0 nM
CC(C)c1cc(NC(=O)c2ccc3cc4n(c3n2)CC(C)(C)CNC4=O)no1 CHEMBL3673652 IC50 125.0 nM
CCN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1967998 pKi 125.89 nM
O=C1CCCN1Cc1ccc2c(c1)[nH]c(=O)c1cccn12 CHEMBL539474 pKi 125.89 nM
Cc1cc(=O)n2ccc(CN(C)C)c(O)c2n1 CHEMBL1988581 pKi 125.89 nM
Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)cncc21 CHEMBL1964692 pKi 125.89 nM
CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccccc3n2)CC1 CHEMBL565612 pKi 125.89 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)cc1C CHEMBL2000335 pKi 125.89 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(F)c2)n1 CHEMBL243298 pKi 125.89 nM
NCC1CCC(CNc2nc(NCc3ccccc3Cl)ncc2[N+](=O)[O-])CC1 CHEMBL246970 pKi 125.89 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1979690 pKi 125.89 nM
Oc1c(F)cc(-c2cnccc2C2CCOCC2)cc1F CHEMBL3604779 IC50 130.0 nM
CNC(=O)c1csc(NC(=O)c2ccc3cc4n(c3n2)C(C)CNC4=O)n1 CHEMBL3673665 IC50 130.0 nM
CCn1c(NC(=O)c2ccc3cc4n(c3n2)CCCNC4=O)nc2ccccc21 CHEMBL3673618 IC50 140.0 nM
Oc1c(F)cc(Nc2ncc3ncn(-c4ccc(Oc5ccccc5)cc4)c3n2)cc1F CHEMBL4860957 IC50 148.0 nM
Cn1c(=O)c(Oc2ccc(F)cc2F)cc2cnc(NC3CCOCC3)nc21 CHEMBL1230122 Kd 150.0 nM
Oc1ccc(-c2[nH]ncc2-c2ccccc2)cc1 CHEMBL3604772 IC50 150.0 nM
CC(=O)Nc1cccc(CNc2c(Nc3ccc4[nH]ncc4c3)c(=O)c2=O)c1 CHEMBL1988608 pKi 158.49 nM
CC(C)(c1cc(Br)c(O)c(I)c1)c1cc(Br)c(O)c(I)c1 CHEMBL1964382 pKi 158.49 nM
Cc1ccc(-c2nn(C(C)(C)C)c3ncnc(N)c23)cc1 CHEMBL306380 pKi 158.49 nM
O=C1NN=Cc2c[nH]c3cc(NC(=O)C4CC4c4ccccc4)cc1c23 CHEMBL1969502 pKi 158.49 nM
NC(COc1cncc(-c2ccc3cnccc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL1981133 pKi 158.49 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(C)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1984162 pKi 158.49 nM
N#Cc1ccc2c(c1)C(c1ccc3c(n1)CCCC3O)C(=O)N2 CHEMBL1985681 pKi 158.49 nM
Cc1cc(C)c(C=C2C(=O)Nc3ccccc32)[nH]1 CHEMBL2002702 pKi 158.49 nM
Nc1ncc(-c2ccncc2)c2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1970083 pKi 158.49 nM
COc1cc2c(cc1F)C(c1ccccc1Cl)=Nc1c(n[nH]c1C)N2 CHEMBL1980391 pKi 158.49 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 166.0 nM
CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3c(cc2OC)CCN3C(=O)CN(C)C)nc2[nH]ccc12 CHEMBL464552 Kd 170.0 nM
CC1CNC(=O)c2cc3ccc(C(=O)Nc4cccnc4)cc3n21 CHEMBL1938774 IC50 170.0 nM
CC1(C)CNC(=O)c2cc3ccc(C(=O)Nc4cc(C(C)(C)C)on4)nc3n2C1 CHEMBL3673650 IC50 175.0 nM
CCN(Cc1cc(Nc2nc(C)cn3c(-c4cn[nH]c4)cnc23)sn1)C(C)(C)CO CHEMBL1232515 IC50 180.0 nM
O=C(Nc1ccc(Cl)cc1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938782 IC50 180.0 nM
Oc1ccc(-c2ccncc2-c2ccc(O)cc2)cc1 CHEMBL3604776 IC50 180.0 nM
CCN(CCO)Cc1cc(Nc2nc(C)cn3c(-c4cn[nH]c4)cnc23)sn1 CHEMBL4228240 IC50 180.0 nM
C[C@@H](Oc1cc(-n2cnc3ccc(CN4CCN(C)CC4)cc32)sc1C(N)=O)c1ccccc1C(F)(F)F CHEMBL1908394 Kd 190.0 nM
CCn1c(NC(=O)c2ccc3cc4n(c3n2)CC(C)(C)CNC4=O)nc2ccccc21 CHEMBL3673619 IC50 195.0 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(-c4ccccc4)c3n2)c1 CHEMBL1988163 pKi 199.53 nM
NC(COc1cncc(-c2cc3cnccc3s2)c1)Cc1c[nH]c2ccccc12 CHEMBL1972840 pKi 199.53 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)O)c5)cnc(N)c34)cc2)c1 CHEMBL1989708 pKi 199.53 nM
Cc1cc(C)cc(NC(=O)Nc2ccc3c(c2)CCc2sc4ncnc(N)c4c2-3)c1 CHEMBL1964687 pKi 199.53 nM
S=c1[nH]nc2c3c4c(sc3n3c(=S)[nH]nc3n12)CCC4 CHEMBL1969537 pKi 199.53 nM
COc1cccc(OC)c1CNc1nc(NC2CCCCC2)nc2ccc(Cl)cc12 CHEMBL1996646 pKi 199.53 nM
CCCCn1c(NC(=O)c2ccc(C#N)cc2)nc2cc(N(C)C(=O)C3CCCCC3)ccc21 CHEMBL484390 pKi 199.53 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 199.53 nM
CSc1ccccc1CNc1ncc([N+](=O)[O-])c(NCC2CCC(CN)CC2)n1 CHEMBL392642 pKi 199.53 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 200.0 nM
C[C@@H]1NC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)nc3n2[C@H]1C CHEMBL3673641 IC50 205.0 nM
CC1(C)CNC(=O)c2cc3ccc(C(=O)Nc4cccnc4)cc3n21 CHEMBL1938775 IC50 210.0 nM
O=C(Nc1ccccn1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938788 IC50 220.0 nM
O=C(OC[C@H]1O[C@@H](n2cnc3c(=O)[nH]cnc32)[C@H](O)[C@@H]1O)c1ccc[nH]1 CHEMBL4636133 IC50 230.0 nM
O=C(Nc1cccnc1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL255210 IC50 240.0 nM
C[C@@H]1CNC(=O)c2cc3ccc(C(=O)Nc4cccnc4)cc3n2[C@@H]1C CHEMBL1938766 IC50 240.0 nM
CN1CCN(c2ccc(-c3c(-c4cn[nH]c4)cnc4[nH]ccc34)cc2)CC1 CHEMBL4280695 IC50 240.0 nM
CN(C)CCCn1c(NC(=O)c2ccc3cc4n(c3n2)CCCNC4=O)nc2ccccc21 CHEMBL3673620 IC50 245.0 nM
Cc1c(NCCN(C)C)cc(Cl)cc1N1CCN(c2ncnc3[nH]nc(Br)c23)CC1 CHEMBL2012702 IC50 248.0 nM
COC(=O)/C=C/c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO CHEMBL4065469 IC50 250.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCNS(C)(=O)=O)cnc(N)c34)cc2)c1 CHEMBL1994321 pKi 251.19 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1998585 pKi 251.19 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN5CCCC5)cnc(N)c34)cc2)c1 CHEMBL1973211 pKi 251.19 nM
c1ccc(Cn2nnc(-c3ccc4[nH]ncc4c3)c2C2CC2)cc1 CHEMBL1975418 pKi 251.19 nM
Cc1cccc(NC(=O)Nc2ccc3c(c2)CCc2sc4ncnc(N)c4c2-3)c1 CHEMBL1242373 pKi 251.19 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CC(C)(C)N)cnc(N)c34)cc2)c1 CHEMBL1979577 pKi 251.19 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccccc1 CHEMBL1999931 pKi 251.19 nM
Cc1[nH]c(C=C2C(=O)Nc3ccccc32)c(C)c1CCC(=O)O CHEMBL2007064 pKi 251.19 nM
CC(=O)CO[C@@H]1[C@@H](OCC(C)=O)[C@@H](O)[C@H](Oc2c(-c3ccc(O)cc3)oc3cc(O)cc(O)c3c2=O)O[C@H]1C CHEMBL2017518 IC50 252.0 nM
Cc1cn2c(-c3cn[nH]c3)cnc2c(Nc2cc(Cc3ccccn3)ns2)n1 CHEMBL4227082 IC50 260.0 nM
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 CHEMBL4569508 IC50 260.0 nM
C[C@H]1CNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)nc3n21 CHEMBL3673638 IC50 265.0 nM
O=C(Nc1cccc(Cl)c1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938783 IC50 270.0 nM
CC(=O)O[C@@H]1[C@@H](OC(C)=O)[C@@H](O)[C@H](Oc2c(-c3ccc(O)cc3)oc3cc(O)cc(O)c3c2=O)C[C@H]1C CHEMBL3356435 IC50 270.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 280.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 290.0 nM
O=C(Nc1ccccc1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938781 IC50 290.0 nM
O=C(Nc1cc(-c2ccccc2)no1)c1ccc2nc3n(c2c1)CCCNC3=O CHEMBL3673582 IC50 290.0 nM
NC(=O)c1ccccc1NC(=O)c1ccc2nc3n(c2c1)CCCNC3=O CHEMBL3673572 IC50 295.0 nM
Cn1c(=O)c(Oc2ccc(F)cc2F)cc2cnc(NC(CCO)CCO)nc21 CHEMBL1090089 Kd 300.0 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1F CHEMBL1981079 pKi 316.23 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCCCCCCCCN)cnc(N)c34)cc2)c1 CHEMBL1978166 pKi 316.23 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 pKi 316.23 nM
Oc1ccc(-c2n[nH]c(Nc3cccc(Cl)c3)c2-c2ccc(O)cc2)cc1 CHEMBL1985092 pKi 316.23 nM
NCCCOc1cc2c(c(-c3ccc(Nc4nc5ccccc5o4)cc3)c1)CNC2=O CHEMBL1975490 pKi 316.23 nM
CC(C)(C)OC(=O)n1ncc2cc(Nc3c(NCc4ccc(Cl)cc4Cl)c(=O)c3=O)ccc21 CHEMBL2005548 pKi 316.23 nM
O=C1NC(=O)c2c1c(-c1ccccc1Cl)cc1[nH]c3ccc(O)cc3c21 CHEMBL379975 pKi 316.23 nM
COc1cc(C=C(C#N)c2nc3cc(C)ccc3[nH]2)c(Br)cc1O CHEMBL2000345 pKi 316.23 nM
COc1cccc(C(CN)NC(=O)c2ccc(-c3ccncc3)cc2)c1 CHEMBL1976240 pKi 316.23 nM
CC(=NNC(=N)N)c1cc(NC(=O)NCCCCCCNC(=O)Nc2cc(C(C)=NNC(=N)N)cc(C(C)=NNC(=N)N)c2)cc(C(C)=NNC(=N)N)c1 CHEMBL1991728 pKi 316.23 nM
Cc1c(N)ccc2[nH]c(-c3ccc(N)cc3)nc12 CHEMBL529177 IC50 320.0 nM
Cn1cc(NC(=O)c2ccc3nc4n(c3c2)CCCNC4=O)cn1 CHEMBL3673576 IC50 320.0 nM
Oc1c(F)cc(Nc2ncc3ncn(-c4cccc(Oc5ccccc5)c4)c3n2)cc1F CHEMBL4845736 IC50 329.0 nM
Cc1cn2c(-c3cn[nH]c3)cnc2c(Nc2cc([C@@H](C)N3C[C@@H](C)O[C@@H](C)C3)ns2)n1 CHEMBL1270399 IC50 330.0 nM
CC1CNC(=O)c2cc3ccc(C(=O)Nc4nccs4)nc3n21 CHEMBL3673666 IC50 330.0 nM
CC1Cn2c(cc3ccc(C(=O)Nc4cccnc4)cc32)C(=O)N1 CHEMBL257321 IC50 350.0 nM
C[C@@H]1O[C@@H](Oc2c(-c3ccc(O)cc3)oc3cc(O)cc(O)c3c2=O)[C@H](O)[C@H](OC(=O)N2CCCC2)[C@H]1OC(=O)N1CCCC1 CHEMBL2017522 IC50 356.0 nM
Cc1cn2c(-c3cn[nH]c3)cnc2c(Nc2cc(CN3CCCCC3)ns2)n1 CHEMBL1739550 IC50 360.0 nM
CC1(C)CNC(=O)c2cc3ccc(C(=O)Nc4cc(Cc5ccccc5)on4)nc3n2C1 CHEMBL3673656 IC50 360.0 nM
N#Cc1cnc(Nc2cc(NC[C@H]3CNCCO3)c(C(F)(F)F)cn2)cn1 CHEMBL4169078 IC50 361.0 nM
Cn1c(NC(=O)c2ccc3cc4n(c3n2)CCCNC4=O)nc2ccccc21 CHEMBL3673614 IC50 365.0 nM
O=C(Nc1nc2ccccc2o1)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938802 IC50 367.0 nM
Cc1cc(NC(=O)c2ccc3cc4n(c3n2)[C@@H](C)CNC4=O)no1 CHEMBL3673646 IC50 380.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1 CHEMBL4550702 IC50 380.0 nM
Cc1cc(NC(=O)c2ccc3cc4n(c3n2)CC(C)(C)CNC4=O)no1 CHEMBL3673654 IC50 395.0 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2C CHEMBL519697 pKi 398.11 nM
O=c1c(NCc2ccc(Cl)c(Cl)c2)c(Nc2ccncc2)c1=O CHEMBL1975900 pKi 398.11 nM
NC(COc1cncc(-c2ccc(F)cc2)c1)Cc1c[nH]c2ccccc12 CHEMBL1996543 pKi 398.11 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 pKi 398.11 nM
NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(-c3ccncc3)ccc2c1=O CHEMBL340384 pKi 398.11 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN(C)C)cnc(N)c34)cc2)c1 CHEMBL1979883 pKi 398.11 nM
NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1998432 pKi 398.11 nM
COc1ccc(C=NNc2ncnc3c2[nH]c2ccccc23)cc1OC CHEMBL1974664 pKi 398.11 nM
Cc1cccc(Nc2nc(NC3CCCCC3N)cnc2C(N)=O)c1 CHEMBL1974328 pKi 398.11 nM
Cc1cc(Cl)ccc1NC(=S)NNC(=O)C(O)(c1ccccc1)c1ccccc1 CHEMBL1988173 pKi 398.11 nM
CC(C)(C)c1nc2c3ccc(F)cc3c3c(=O)[nH]ccc3c2[nH]1 CHEMBL21156 pKi 398.11 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cn[nH]c5)cnc(N)c34)cc2)c1 CHEMBL1969102 pKi 398.11 nM
CCN(CC)CC#Cc1ccc2c(c1)-c1[nH]nc(-c3ccc(C#N)nc3)c1C2 CHEMBL2007044 pKi 398.11 nM
Cc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1Nc1ccc(OCC(N)=O)cc1 CHEMBL1988838 pKi 398.11 nM
COc1cccc(C(C)NC(=O)c2ccc(-c3ccncc3C)cc2)c1 CHEMBL1970217 pKi 398.11 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 398.11 nM
O=C(NN=Cc1cc(Br)c(O)c(Br)c1)Nc1ccccc1 CHEMBL1983575 pKi 398.11 nM
COc1ccc(-c2ccc(NC(=O)Nc3ccc(F)c(C)c3)cc2)c2c(N)noc12 CHEMBL1979093 pKi 398.11 nM
N#Cc1ccc(-c2n[nH]c3c2Cc2ccc(OCCN4CCOCC4)cc2-3)cn1 CHEMBL249282 pKi 398.11 nM
N#C/C(=C/c1cccc(-c2ncnc3[nH]ccc23)c1)C(N)=O CHEMBL5278864 IC50 399.0 nM
N#C/C(=C\c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N)=O CHEMBL5270221 IC50 399.0 nM
COc1ccccc1NC(=O)c1ccc2cc3n(c2c1)CCCNC3=O CHEMBL1938785 IC50 400.0 nM
O=C(Nc1cccnc1)c1ccc2cc3n(c2c1)CC1(CC1)CNC3=O CHEMBL1938770 IC50 410.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 440.0 nM
CCC[C@@H]1O[C@@H](Oc2c(-c3ccc(O)cc3)oc3cc(O)cc(O)c3c2=O)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1NC(C)=O CHEMBL5419696 IC50 440.0 nM
Oc1ccc(NCn2nnc3ccccc32)cc1 CHEMBL1775067 IC50 480.0 nM
CC(C)C[C@@H]1O[C@@H](Oc2c(-c3ccc(O)cc3)oc3cc(O)cc(O)c3c2=O)[C@H](O)[C@H](O)[C@H]1O CHEMBL2326706 IC50 480.0 nM
C[C@H]1CNC(=O)c2cc3ccc(C(=O)Nc4cc(Cc5ccccc5)on4)nc3n21 CHEMBL3673660 IC50 490.0 nM
C[C@@H]1O[C@@H](Oc2c(-c3ccc(O)cc3)oc3cc(O)cc(O)c3c2=O)[C@H](O)[C@H](OC(=O)N(C)C)[C@H]1OC(=O)N(C)C CHEMBL2017521 IC50 493.0 nM
COc1c(F)cc(-c2cnc3[nH]ccc3c2-c2ccc(N3CCN(C)CC3)cc2)cc1F CHEMBL4276872 IC50 500.0 nM
O=S(=O)(NCCNCC=Cc1ccc(Br)cc1)c1cccc2cnccc12 CHEMBL1987756 pKi 501.19 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3coc4c(C#CCN5CCOCC5)cnc(N)c34)cc2)c1 CHEMBL1983640 pKi 501.19 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)csc12 CHEMBL1982476 pKi 501.19 nM
O=C1Nc2ccccc2C1=Cc1ccc[nH]1 CHEMBL1996176 pKi 501.19 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl CHEMBL458997 pKi 501.19 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 CHEMBL49120 pKi 501.19 nM
CCC(=O)Nc1ccc(C(=O)N2CCNCC2)c(O)c1 CHEMBL1988141 pKi 501.19 nM
Cn1cc(-c2cc3nc(Br)cnc3[nH]2)c2cc(F)ccc21 CHEMBL1993335 pKi 501.19 nM
CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL1084546 pKi 501.19 nM
NCC(NC(=O)c1ccc(-c2ccncc2)cc1)c1ccccc1 CHEMBL1990254 pKi 501.19 nM
CCC(N)(C#Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12)CC CHEMBL1983025 pKi 501.19 nM
O=c1c(NCc2cccc(C(F)(F)F)c2)c(Nc2ccncc2)c1=O CHEMBL1979252 pKi 501.19 nM
C#Cc1cc2c(cc1OC)-c1[nH]nc(-c3ccc(C#N)nc3)c1C2 CHEMBL1972250 pKi 501.19 nM
COc1cc2ncc3c(N)nc4c(C)c(N)ccc4c3c2cc1OC CHEMBL235157 pKi 501.19 nM
N#Cc1ncc2nc1OCC(O)C(O)COc1ccc(Cl)cc1NC(=O)N2 CHEMBL1980802 pKi 501.19 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(Cl)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1987054 pKi 501.19 nM
O=c1c(NCc2ccccc2F)c(Nc2ccncc2)c1=O CHEMBL1982361 pKi 501.19 nM
CNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCNCC4)cc3)n2)s1 CHEMBL1999484 pKi 501.19 nM
CC1(C)CNC(=O)c2cc3ccc(C(=O)Nc4cc(-c5ccccc5)on4)nc3n2C1 CHEMBL3673655 IC50 502.0 nM
Cn1ccc(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)n1 CHEMBL1938795 IC50 540.0 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccccc4)c3)cc12 CHEMBL379218 Ki 580.0 nM
N=C(N)N/N=C\c1c(-c2ccc([N+](=O)[O-])cc2)nc2sc(Br)cn12 CHEMBL1910608 IC50 607.1 nM
CCC[C@@H]1O[C@@H](Oc2c(-c3ccc(O)cc3)oc3cc(O)cc(O)c3c2=O)[C@H](OC(C)=O)[C@H](O)[C@H]1OC(C)=O CHEMBL2326708 IC50 620.0 nM
CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(-c4ccncc4)cc3)n2)c(=O)c1=O CHEMBL2205426 Ki 630.0 nM
CC(C)n1c(NC(=O)c2ccc3cc4n(c3n2)CCCNC4=O)nc2ccccc21 CHEMBL3673616 IC50 630.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL244378 pKi 630.96 nM
O=C(NCc1ccc(Cl)c(Cl)c1)Nc1ccc2[nH]ncc2c1 CHEMBL1981782 pKi 630.96 nM
COc1cc2c(cc1Nc1nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN(C)C)CC2 CHEMBL461876 pKi 630.96 nM
O=C(NNC(=S)Nc1ccc(Cl)cc1)C(O)(c1ccccc1)c1ccccc1 CHEMBL1966722 pKi 630.96 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN)cnc(N)c34)cc2)c1 CHEMBL1965988 pKi 630.96 nM
NC(=O)c1cc2c(-c3ccc(Nc4nc5ccccc5o4)cc3)cnc(N)c2s1 CHEMBL1993904 pKi 630.96 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(-c3c(C)sc4ncnc(N)c34)cc2)c1 CHEMBL371206 pKi 630.96 nM
Cc1ccc(-c2cc(-c3cc(Br)ccc3O)[nH]c(=O)c2C#N)s1 CHEMBL1997193 pKi 630.96 nM
COc1ccc(-c2ccc(NC(=O)Nc3cccc(Br)c3)cc2)c2c(N)noc12 CHEMBL271381 pKi 630.96 nM
NC(=O)c1ccc2nc(-c3ccc([N+](=O)[O-])o3)cn2c1 CHEMBL1973359 pKi 630.96 nM
CC(C)(C(N)=O)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1967720 pKi 630.96 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 pKi 630.96 nM
COc1ccccc1C1=C(c2cn(CCCNC(=O)OC(C)(C)C)c3ncccc23)C(=O)NC1=O CHEMBL109981 IC50 640.0 nM
O=C(OC[C@H]1O[C@@H](n2cnc3c(=O)[nH]cnc32)[C@H](O)[C@@H]1O)c1cc[nH]c1 CHEMBL4637966 IC50 640.0 nM
Nc1nc2c(ncn2[C@@H]2O[C@H](COC(=O)c3ccc[nH]3)[C@@H](O)[C@H]2O)c(=O)[nH]1 CHEMBL4642516 IC50 660.0 nM
Nc1nc2c(ncn2[C@@H]2O[C@H](COC(=O)c3cc[nH]c3)[C@@H](O)[C@H]2O)c(=O)[nH]1 CHEMBL4634615 IC50 680.0 nM
CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21 CHEMBL3884319 IC50 692.0 nM
CCC[C@@H]1O[C@@H](Oc2c(-c3ccc(O)cc3)oc3cc(O)cc(O)c3c2=O)[C@H](O)[C@H](O)[C@H]1O CHEMBL2326705 IC50 710.0 nM
O=C(Nc1cccnc1)c1ccc2cc3n(c2c1)CCNC3=O CHEMBL404908 IC50 730.0 nM
CCNC(=O)C#Cc1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN(C)C)cc1)c1ccccc1 CHEMBL3699142 Kd apparent 734.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 740.0 nM
Cc1ccc(-c2c(/C=C/C#N)n(CCCO)c3ncnc(N)c23)cc1 CHEMBL4069201 IC50 750.0 nM
CC(C)c1ccncc1-c1cc(F)c(O)c(F)c1 CHEMBL3604781 IC50 780.0 nM
Cc1nc2ccc(NS(=O)(=O)c3ccc(N)cc3)cc2nc1C CHEMBL2006263 pKi 794.33 nM
CC(O)Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL2002165 pKi 794.33 nM
COc1cccc(C(C)NC(=O)c2ccc(-c3ccncc3)c(F)c2)c1 CHEMBL2004934 pKi 794.33 nM
Cc1ccc(-c2cc3c(NCCN)ccc(C(N)=O)c3[nH]2)cc1 CHEMBL1996048 pKi 794.33 nM
CC(C)(CN)CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1985723 pKi 794.33 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(OC(F)F)cc5)cc4)csc23)cn1 CHEMBL1988387 pKi 794.33 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc([N+](=O)[O-])cc2)n1 CHEMBL242865 pKi 794.33 nM
CC(=NNC(=N)N)c1cc(NC(=O)NCCCN(C)CCCNC(=O)Nc2cc(C(C)=NNC(=N)N)cc(C(C)=NNC(=N)N)c2)cc(C(C)=NNC(=N)N)c1 CHEMBL1993166 pKi 794.33 nM
CC(C)(C)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1970104 pKi 794.33 nM
N#Cc1ccc(-c2n[nH]c3c2Cc2ccc(OCCCCN4CCOCC4)cc2-3)cn1 CHEMBL398951 pKi 794.33 nM
Nc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL2007574 pKi 794.33 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)c1 CHEMBL196363 pKi 794.33 nM
CNCC#Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL1964441 pKi 794.33 nM
Cc1ccc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)cc1 CHEMBL1972576 pKi 794.33 nM
COc1ccc(-n2ccc3cnc(Nc4cc(OC)c(OC)c(OC)c4)nc32)cc1 CHEMBL1975927 pKi 794.33 nM
COc1cc(C=C(C#N)c2nc3ccccc3[nH]2)c(Br)cc1O CHEMBL1994241 pKi 794.33 nM
COc1c(-c2nc3ccccc3[nH]2)c(O)cc2oc(C)cc(=O)c12 CHEMBL1972355 pKi 794.33 nM
CCNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)n2)s1 CHEMBL1983715 pKi 794.33 nM
NC(=O)c1cc2c(-c3cccc(F)c3)cncc2s1 CHEMBL1971017 pKi 794.33 nM
NC(COc1cncc(C=Cc2ccncc2)c1)Cc1c[nH]c2ccccc12 CHEMBL1974935 pKi 794.33 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CCO)c5)cnc(N)c34)cc2F)c1 CHEMBL1986851 pKi 794.33 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4ccc(OC(F)F)cc4)cc3)c12 CHEMBL1972220 pKi 794.33 nM
O=c1nc(-c2ccc3[nH]ncc3c2)cc(-c2ccccc2)[nH]1 CHEMBL526133 pKi 794.33 nM
NCCNS(=O)(=O)c1cccc(C(=O)Nc2ccc(-c3n[nH]c(=O)c4ccccc34)cc2)c1 CHEMBL2000481 pKi 794.33 nM
CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O CHEMBL189963 pKi 794.33 nM
NC(=O)c1cc2c(-c3ccccc3)cncc2s1 CHEMBL1999556 pKi 794.33 nM
CNC(=O)c1ccccc1Sc1ccc2c(C=Cc3ccccn3)n[nH]c2c1 CHEMBL1988437 pKi 794.33 nM
COc1cc(Nc2ncc3c(n2)-c2ccc(Cl)cc2C(c2c(F)cccc2OC)=NC3)ccc1C(=O)O CHEMBL483158 pKi 794.33 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(F)c1 CHEMBL2003638 pKi 794.33 nM
COc1cc(CN2CCCCC2)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL202635 pKi 794.33 nM
CN1CCN(c2ccc(-c3c(-c4ccc(C(F)F)cc4)cnc4[nH]ccc34)cc2)CC1 CHEMBL4277304 IC50 800.0 nM
Nc1ncnc2c1ncn2[C@@H]1O[C@H](COC(=O)c2ccc[nH]2)[C@@H](O)[C@H]1O CHEMBL4633057 IC50 800.0 nM
CN1CCN(c2ccc(-c3c(-c4ccc(N)nc4)cnc4[nH]ccc34)cc2)CC1 CHEMBL4288604 IC50 810.0 nM
CCCNC(=O)O[C@@H]1[C@@H](OC(=O)NCCC)[C@@H](O)[C@H](Oc2c(-c3ccc(O)cc3)oc3cc(O)cc(O)c3c2=O)O[C@H]1C CHEMBL2017519 IC50 869.0 nM
CC(C)n1ncc2cc(NC(=O)c3ccc4nc5n(c4c3)CCCNC5=O)cnc21 CHEMBL3673574 IC50 870.0 nM
CCCNC(=O)O[C@H]1[C@H](CCC)C[C@@H](Oc2c(-c3ccc(O)cc3)oc3cc(O)cc(O)c3c2=O)[C@H](O)[C@@H]1OC(=O)NCCC CHEMBL5401630 IC50 870.0 nM
CCC[C@@H]1C[C@@H](Oc2c(-c3ccc(O)cc3)oc3cc(O)cc(O)c3c2=O)[C@H](O)[C@H](OC(C)=O)[C@H]1OC(C)=O CHEMBL5439691 IC50 870.0 nM
C[C@@H]1[C@@H](C)NC(=O)c2cc3ccc(C(=O)Nc4cccnc4)cc3n21 CHEMBL1938777 IC50 871.0 nM
CC1=C(C#N)C(c2ccc3[nH]nc(C)c3c2)C(C#N)=C(C)N1 CHEMBL4593677 IC50 900.0 nM
O=C1c2ccccc2C(=O)N1CNc1ccc(N2CCOCC2)cc1 CHEMBL1775068 IC50 950.0 nM
O=C(Nc1cccc(F)c1)c1ccc2nc3n(c2c1)CCCNC3=O CHEMBL3673571 IC50 960.0 nM
N=C(N)N/N=C/c1c(-c2ccc([N+](=O)[O-])cc2)nc2sc(Cl)cn12 CHEMBL1910625 IC50 970.0 nM
NCC1Cn2c(cc3ccc(C(=O)Nc4cccnc4)cc32)C(=O)N1 CHEMBL1938778 IC50 970.0 nM
Nc1ncnc2c1ncn2[C@@H]1O[C@H](COC(=O)c2cc[nH]c2)[C@@H](O)[C@H]1O CHEMBL4647499 IC50 970.0 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1 CHEMBL428690 Kd 1000.0 nM
CN1c2ccc(N)cc2C(c2ccccc2)c2cc(N)ccc21 CHEMBL1991734 pKi 1000.0 nM
Cn1cc(-c2cc3nc(Br)cnc3[nH]2)c2cc(C#N)ccc21 CHEMBL1978562 pKi 1000.0 nM
COCOc1cccc(OCOC)c1-c1ccc(NS(C)(=O)=O)cc1C(=O)OC CHEMBL2004025 pKi 1000.0 nM
NC(=O)c1cc2c(-c3ccc(Br)c(F)c3F)cncc2s1 CHEMBL1999918 pKi 1000.0 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCC(N)=O CHEMBL485556 pKi 1000.0 nM
O=C1C(=NNc2cccc3c(=O)[nH][nH]c(=O)c23)C(c2ccccc2)=NN1c1ccccc1 CHEMBL1984274 pKi 1000.0 nM
O=c1c(NCc2ccc(Cl)cc2)c(Nc2ccncc2)c1=O CHEMBL1980489 pKi 1000.0 nM
O=S(=O)(c1cccc2cnccc12)N1CCCNCC1 CHEMBL38380 pKi 1000.0 nM
NC(=O)c1cccc(-c2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982957 pKi 1000.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#Cc5cccnc5)cnc(N)c34)cc2)c1 CHEMBL1971947 pKi 1000.0 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 1000.0 nM
N#CC1=C(c2ccccc2)CC(c2ccc(Cl)cc2)C(C(=O)c2ccccc2)C1=O CHEMBL1978371 pKi 1000.0 nM
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=O)c1c(F)cccc1F CHEMBL191003 pKi 1000.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccccc4)c3)cc12 CHEMBL2002726 pKi 1000.0 nM
Clc1cc(NC2CCCCC2)nc(-c2c[nH]c3ncccc23)n1 CHEMBL1997846 pKi 1000.0 nM
OCCC(Nc1nc2ccc(-c3ccncc3)cc2s1)c1ccccc1 CHEMBL1982122 pKi 1000.0 nM
COc1cccc(C(C)NC(=O)c2ccc(-c3ccncc3F)cc2OC)c1 CHEMBL1991188 pKi 1000.0 nM
Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c12 CHEMBL1976220 pKi 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM