CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CC2CN(C)C2)CC1 CHEMBL3936990 IC50 0.06 nM
Cc1cc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4Br)CC3)n2)ccc1F CHEMBL3899716 IC50 0.1 nM
CC(C)c1cc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4Br)CC3)n2)ccn1 CHEMBL3966806 IC50 0.11 nM
CNCC(Nc1ncnc2c(C(N)=O)cc(OC)cc12)c1ccccc1 CHEMBL3675393 IC50 0.12 nM
CN(C)CC(Nc1ncnc2c(C(N)=O)cccc12)c1ccc(C(F)(F)F)cc1 CHEMBL3675394 IC50 0.14 nM
CNC[C@@H](Nc1ncnc2c(C(N)=O)cc(OC)cc12)c1cccc(Cl)c1 CHEMBL3685328 IC50 0.2 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(Cl)c3)cn2CCN2CCCC2)CC1 CHEMBL3906990 IC50 0.2 nM
CC(C)CNCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3980521 IC50 0.2 nM
COc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CC2CNC2)CC1 CHEMBL3981085 IC50 0.26 nM
CNC[C@H](/N=C1\NC=NC2C=CCC=C12)c1ccccc1 CHEMBL3675395 IC50 0.28 nM
CNCC(Nc1ncnc2c(C(N)=O)cccc12)c1ccc(Cl)c(Cl)c1 CHEMBL3675396 IC50 0.36 nM
COc1cc(C(N)=O)c2ncnc(N[C@H](CN)c3ccccc3)c2c1 CHEMBL3675397 IC50 0.39 nM
CNCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3894849 IC50 0.4 nM
CNCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(F)c(F)c2)c1 CHEMBL3675398 IC50 0.42 nM
CNCC(Nc1ncnc2c(C(N)=O)cc(OC)cc12)c1cccc(F)c1 CHEMBL3675399 IC50 0.42 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.43 nM
CCNCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2OC(C)C)CC1 CHEMBL3943127 IC50 0.44 nM
NCC(Nc1ncnc2c(C(N)=O)cccc12)c1ccc(Cl)c(Cl)c1 CHEMBL3670401 IC50 0.5 nM
NCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(F)c1 CHEMBL3675326 IC50 0.5 nM
COc1ccc(C(CN)Nc2ncnc3c(C(N)=O)cccc23)cc1OC CHEMBL3675331 IC50 0.5 nM
Nc1ncnc(N2CCC(c3nc(-c4ccnc(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1Br CHEMBL3977147 IC50 0.5 nM
Nc1ncnc(N2CCC(c3nc(-c4cccc(F)c4)cn3CCN3CCCC3)CC2)c1Cl CHEMBL3978595 IC50 0.5 nM
Cc1cc(-c2cn(CCN(C)C)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)ccc1F CHEMBL3971598 IC50 0.5 nM
Cc1ccc(CNc2ncnc3c(C(N)=O)cccc23)cc1C CHEMBL3675400 IC50 0.53 nM
CN(C)CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(C(F)(F)F)cc2)c1 CHEMBL3675401 IC50 0.55 nM
CN(C)CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccccc2F)c1 CHEMBL3675402 IC50 0.58 nM
Cc1ccc(C(CN)Nc2ncnc3c(C(N)=O)cccc23)cc1 CHEMBL3670404 IC50 0.6 nM
NC[C@@H](Nc1ncnc2c(C(N)=O)cccc12)c1ccccc1 CHEMBL3670464 IC50 0.6 nM
CNC[C@@H](Nc1ncnc2c(C(N)=O)cccc12)c1cccc(F)c1 CHEMBL3685329 IC50 0.6 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C=O)CC1 CHEMBL3904322 IC50 0.6 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccnc(C(F)(F)F)c3)cn2CCNC)CC1 CHEMBL3910789 IC50 0.6 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1Cl CHEMBL3919089 IC50 0.6 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCCC3)CC2)c1C=O CHEMBL3941283 IC50 0.6 nM
CNCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(Br)cc2)c1 CHEMBL3675403 IC50 0.61 nM
CN(C)CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(Br)cc2)c1 CHEMBL3675404 IC50 0.65 nM
CNCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(Cl)c1 CHEMBL3675405 IC50 0.66 nM
CN(C)CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccnc(N3CCCC3)c2)c1 CHEMBL3675406 IC50 0.68 nM
CNC[C@@H](Nc1ncnc2c(C(N)=O)cc(OC)cc12)c1cccc(F)c1 CHEMBL3675407 IC50 0.68 nM
COc1ccc(C(CN)Nc2ncnc3c(C(N)=O)cccc23)cc1 CHEMBL3670495 IC50 0.7 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1-c1cc[nH]c1 CHEMBL3965271 IC50 0.7 nM
Cc1cc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)ccc1F CHEMBL3961056 IC50 0.7 nM
C=Cc1c(N)ncnc1N1CCC(c2nc(-c3ccnc(C(C)C)c3)cn2CCN2CCC2)CC1 CHEMBL3891980 IC50 0.7 nM
CNCC(Nc1ncnc2c(C(N)=O)cc(OC)cc12)c1cccc(Cl)c1 CHEMBL3675408 IC50 0.72 nM
Cc1cc(-c2cn(CCN(C)C)c(C3CCN(c4ncnc(N)c4-c4cn[nH]c4)CC3)n2)ccc1F CHEMBL3957657 IC50 0.73 nM
O=C1Nc2ccccc2/C1=C/c1c[nH]nc1-c1ccccc1[N+](=O)[O-] CHEMBL2347053 IC50 0.75 nM
CN(C)CC(Nc1ncnc2c(C(N)=O)cccc12)c1ccc(Cl)c(Cl)c1 CHEMBL3675409 IC50 0.79 nM
CN(C)CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccnc(N3CCCCC3)c2)c1 CHEMBL3675410 IC50 0.8 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3cnc(F)c(Cl)c3)cn2CCN2CCC2)CC1 CHEMBL3966203 IC50 0.8 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)cc4)cn3CCN3CCCC3)CC2)c1Cl CHEMBL3912632 IC50 0.8 nM
CCOc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(Cl)c3)cn2CCN2CCCC2)CC1 CHEMBL3928772 IC50 0.8 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(Cl)c3)cn2CCN2CCCC2)CC1 CHEMBL3967010 IC50 0.8 nM
Cc1ccc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)cc1C(F)(F)F CHEMBL3949201 IC50 0.8 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCO)CC1 CHEMBL3913464 IC50 0.8 nM
Cc1cc(-c2cn(CCNCC3CC3)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)ccc1F CHEMBL3972479 IC50 0.8 nM
Cc1cc(-c2cn(CCN(C)C(C)C)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)ccc1F CHEMBL3963056 IC50 0.8 nM
NC[C@H](c1ccc(Cl)nc1)N1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1 CHEMBL4106847 IC50 0.8 nM
CN(C)CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccnc(Cl)c2)c1 CHEMBL3675411 IC50 0.81 nM
CNCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccccc2)c1 CHEMBL3675412 IC50 0.82 nM
CNCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2c(F)cccc2F)c1 CHEMBL3675413 IC50 0.84 nM
CN(C)CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(Br)c1 CHEMBL3675414 IC50 0.89 nM
NC(=O)c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(Cl)c3)cn2CCN2CCC2)CC1 CHEMBL3962020 IC50 0.9 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1-c1cnoc1 CHEMBL3941451 IC50 0.9 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2C2CCNCC2)CC1 CHEMBL3906695 IC50 0.9 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(F)c4)cn3CCN3CCCC3)CC2)c1Cl CHEMBL3940627 IC50 0.9 nM
C=Cc1c(N)ncnc1N1CCC(c2nc(-c3cccc(F)c3)cn2CCN2CCCC2)CC1 CHEMBL3928074 IC50 0.9 nM
CC(C)NCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C(N)=O)CC1 CHEMBL3919834 IC50 0.9 nM
Cc1cc(-c2cn(CCNC3CCCC3)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)ccc1F CHEMBL3927358 IC50 0.9 nM
CNCCn1cc(-c2ccc(F)c(C)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3969016 IC50 0.9 nM
NCC(c1ccc(Cl)c(F)c1)N1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1 CHEMBL3929756 IC50 0.9 nM
CNCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(F)c1 CHEMBL3675415 IC50 0.95 nM
CNCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(OC)c(F)c2)c1 CHEMBL3675416 IC50 0.99 nM
Cc1c(NCCN2CCCC2)cc(OCC(C)C)cc1N1CCN(c2ncnc3[nH]nc(Br)c23)CC1 CHEMBL2016886 IC50 1.0 nM
Cc1c(NCCN2CCCC2)cc(C(=O)Nc2ccccc2)cc1N1CCN(c2ncnc3[nH]nc(Br)c23)CC1 CHEMBL2016887 IC50 1.0 nM
Cc1noc(-c2cc(NCCN3CCCC3)c(C)c(N3CCN(c4ncnc5[nH]nc(Br)c45)CC3)c2)n1 CHEMBL2016890 IC50 1.0 nM
CCC(=O)c1cc(NCCN2CCCC2)c(C)c(N2CCN(c3ncnc4[nH]nc(Br)c34)CC2)c1 CHEMBL2016892 IC50 1.0 nM
CN(C)CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(C(F)(F)F)cc2F)c1 CHEMBL3675417 IC50 1.0 nM
CN(C)CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccnc(N(C)C)c2)c1 CHEMBL3675418 IC50 1.0 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(Cl)c3)cn2CCN2CCC2)CC1 CHEMBL3940867 IC50 1.0 nM
COc1cc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)ccc1F CHEMBL3938454 IC50 1.0 nM
COc1cc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4C(N)=O)CC3)n2)ccc1F CHEMBL3933597 IC50 1.0 nM
Nc1ncnc(N2CCC(c3nc(-c4ccnc(C(F)(F)F)c4)cn3CCNCCCCl)CC2)c1Br CHEMBL3951747 IC50 1.0 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1C=O CHEMBL3890352 IC50 1.0 nM
CCOc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CCN(C)C)CC1 CHEMBL3948085 IC50 1.0 nM
NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3ccc(F)c(F)c3)ncnc12 CHEMBL4860970 IC50 1.0 nM
NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3ccc(C(F)(F)F)cc3)ncnc12 CHEMBL4871853 IC50 1.0 nM
CNCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(OC)cc2)c1 CHEMBL3675419 IC50 1.1 nM
CN(C)CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2cncc(N3CCCC3)c2)c1 CHEMBL3675420 IC50 1.1 nM
CN(C)CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(Cl)c1 CHEMBL3675421 IC50 1.1 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN)CC1 CHEMBL3968744 IC50 1.1 nM
Nc1ncnc(N2CCC(c3nc(-c4ccnc(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1Cl CHEMBL3980922 IC50 1.1 nM
CC(C)c1cc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4Cl)CC3)n2)ccn1 CHEMBL3912769 IC50 1.1 nM
Cc1cc(-c2cn(CC3CNC3)c(C3CCN(c4ncnc(N)c4C(C)C)CC3)n2)ccc1F CHEMBL3974201 IC50 1.1 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(F)c3)cn2CCN2CCCC2)CC1 CHEMBL3954781 IC50 1.1 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCNCC2CC2)CC1 CHEMBL3983282 IC50 1.1 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCNC2CCCC2)CC1 CHEMBL3960355 IC50 1.1 nM
NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3ccc(Cl)c(C(F)(F)F)c3)ncnc12 CHEMBL4871106 IC50 1.1 nM
NCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(F)cc2)c1 CHEMBL3670412 IC50 1.2 nM
NC(=O)c1cccc2c(NCc3ccc(Cl)c(C(F)(F)F)c3)ncnc12 CHEMBL3675365 IC50 1.2 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3962807 IC50 1.2 nM
CCOc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CCN2CCC2)CC1 CHEMBL3916178 IC50 1.2 nM
COc1ccc(C(=O)Nc2cccc(C(CN(C)C)Nc3ncnc4c(C(N)=O)cccc34)c2)cc1 CHEMBL3675422 IC50 1.3 nM
CNCC(Nc1ncnc2c(C(N)=O)ccc(OC)c12)c1ccccc1 CHEMBL3675423 IC50 1.3 nM
CNCC(Nc1ncnc2c(C(N)=O)cccc12)c1ccc(OC)cc1 CHEMBL3675424 IC50 1.3 nM
CNCCn1cc(-c2ccnc(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2Br)CC1 CHEMBL3899490 IC50 1.3 nM
CNCCn1cc(-c2ccnc(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3949795 IC50 1.3 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(F)c4)cn3CCN3CCCC3)CC2)c1Br CHEMBL3944201 IC50 1.3 nM
CC(C)Oc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(Cl)c3)cn2CCN2CCCC2)CC1 CHEMBL3904291 IC50 1.3 nM
Cc1cc(-c2cn(CCN(C)C)c(C3CCN(c4ncnc(N)c4OC(C)C)CC3)n2)ccc1F CHEMBL3984164 IC50 1.3 nM
Cc1ccc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)cc1Cl CHEMBL3980667 IC50 1.3 nM
CC(C)(C)NCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3895898 IC50 1.3 nM
Cc1cc(-c2cn(CCNC(C)C)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)ccc1F CHEMBL3890076 IC50 1.3 nM
NCC(c1ccc(Cl)cc1)N1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1 CHEMBL3942270 IC50 1.3 nM
NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3cccc(Cl)c3)ncnc12 CHEMBL4855657 IC50 1.3 nM
CNCC(Nc1ccccc(C(N)=O)cncn1)c1cccc(NC(=O)c2ccc(OC(F)(F)F)cc2)c1 CHEMBL3675425 IC50 1.4 nM
COc1cc(C(N)=O)c2ncnc(NC(CN(C)C)c3ccc(Cl)cc3)c2c1 CHEMBL3675426 IC50 1.4 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2ccncc2)CC1 CHEMBL3978717 IC50 1.4 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)cc4)cn3CCN3CCCC3)CC2)c1Br CHEMBL3911853 IC50 1.4 nM
Nc1ncnc(N2CCC(c3nc(-c4cccc(F)c4)cn3CCN3CCCC3)CC2)c1Br CHEMBL3949523 IC50 1.4 nM
C=Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(F)c3)cn2CCN2CCCC2)CC1 CHEMBL3913177 IC50 1.4 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(Cl)c4)cn3CCN3CCCC3)CC2)c1Br CHEMBL3980219 IC50 1.4 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1[N+](=O)[O-] CHEMBL3927590 IC50 1.4 nM
CCc1cc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)ccn1 CHEMBL3936879 IC50 1.4 nM
COCCNCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3903066 IC50 1.4 nM
NC(=O)c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCNC2CCCC2)CC1 CHEMBL3951639 IC50 1.4 nM
NCC(c1ccc(OC(F)(F)F)cc1)N1CCN(c2ncnc(N)c2-c2cn[nH]c2)CC1 CHEMBL3896291 IC50 1.4 nM
NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3cccc(C(F)(F)F)c3)ncnc12 CHEMBL4876446 IC50 1.4 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3941307 IC50 1.5 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccnc(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3947888 IC50 1.5 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN)CC1 CHEMBL3899777 IC50 1.5 nM
NCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C(N)=O)CC1 CHEMBL3926535 IC50 1.5 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1Br CHEMBL3894578 IC50 1.5 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3cccc(Cl)c3)cn2CCN2CCCC2)CC1 CHEMBL3905187 IC50 1.5 nM
NC(=O)c1cccc2c(NCc3ccc(Cl)c(Cl)c3)ncnc12 CHEMBL3675339 IC50 1.6 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2cccc(F)c2)CC1 CHEMBL3912964 IC50 1.6 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CCN(CC)CC)CC1 CHEMBL3891820 IC50 1.6 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(F)c3)cn2CCN2CCC2)CC1 CHEMBL3950203 IC50 1.6 nM
Cc1ccc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)cc1F CHEMBL3965676 IC50 1.6 nM
NC(=O)c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCO)CC1 CHEMBL3949232 IC50 1.6 nM
COc1cc(C(N)=O)c2ncnc(NCc3cccc(NC(=O)c4ccc(F)cc4)c3)c2c1 CHEMBL3670476 IC50 1.7 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)c[nH]3)CC2)c1Br CHEMBL3906130 IC50 1.7 nM
NC(=O)c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2C2CCNC2)CC1 CHEMBL3908032 IC50 1.7 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(C(F)(F)F)c(F)c3)cn2CCN2CC[C@@H](F)C2)CC1 CHEMBL4108380 IC50 1.7 nM
CC(C)c1cc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)ccn1 CHEMBL3966620 IC50 1.7 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccnc(C4CC4)c3)cn2CCN2CCC2)CC1 CHEMBL3968742 IC50 1.7 nM
CCC(C)(C)NCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3891300 IC50 1.7 nM
CN(C)C[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1 CHEMBL3896704 IC50 1.7 nM
COc1cc(C(N)=O)c2ncnc(NCc3ccc(Cl)c(C(F)(F)F)c3)c2c1 CHEMBL3670482 IC50 1.8 nM
CN(C)CCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3916864 IC50 1.8 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CC2CCCN2)CC1 CHEMBL3968352 IC50 1.8 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(OC(F)F)c(F)c3)cn2CCN2CCC2)CC1 CHEMBL3972741 IC50 1.8 nM
Cc1cc(-c2cn(CCO)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)ccc1F CHEMBL3900331 IC50 1.8 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2ccc(CO)cc2)CC1 CHEMBL3910716 IC50 1.9 nM
CCO/C=C/c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN(C)C)CC1 CHEMBL3973987 IC50 1.9 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccnc(C(C)C)c3)cn2CCN2CCC2)CC1 CHEMBL3944209 IC50 1.9 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCCC2)CC1 CHEMBL3959291 IC50 1.9 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCCCC2)CC1 CHEMBL3927877 IC50 1.9 nM
Cc1cc(-c2cn(CCNCC(C)C)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)ccc1F CHEMBL3954981 IC50 1.9 nM
NCCC(C(=O)Nc1ccc2[nH]ncc2c1)c1ccc(Cl)c(Cl)c1 CHEMBL1998121 pKi 1.995 nM
CCc1n[nH]c2ncnc(N3CCN(c4cc(Cl)cc(CCCN5CCCC5)c4C)CC3)c12 CHEMBL2012698 IC50 2.0 nM
CCc1n[nH]c2ncnc(N3CCN(c4cc(Cl)cc(NCCN(C)C)c4C)CC3)c12 CHEMBL2012701 IC50 2.0 nM
Cc1c(NCCN(C)C)cc(Cl)cc1N1CCN(c2ncnc3[nH]nc(Br)c23)CC1 CHEMBL2012702 IC50 2.0 nM
Cc1c(NCCN2CCCC2)cc(Cl)cc1N1CCN(c2ncnc3[nH]nc(Br)c23)CC1 CHEMBL2016771 IC50 2.0 nM
CCOc1cc(NCCN2CCCC2)c(C)c(N2CCN(c3ncnc4[nH]nc(Br)c34)CC2)c1 CHEMBL2016885 IC50 2.0 nM
Cc1c(NCCN2CCCC2)cc(COCC(F)(F)F)cc1N1CCN(c2ncnc3[nH]nc(Br)c23)CC1 CHEMBL2016888 IC50 2.0 nM
Cc1c(NCCN2CCCC2)cc(CCC(C)(C)C)cc1N1CCN(c2ncnc3[nH]nc(Br)c23)CC1 CHEMBL2016889 IC50 2.0 nM
COC(=O)c1cc(NCCN2CCCC2)c(C)c(N2CCN(c3ncnc4[nH]nc(Br)c34)CC2)c1 CHEMBL2016891 IC50 2.0 nM
Cc1c(NCCN2CCCC2)cc(C(=O)CCC(F)(F)F)cc1N1CCN(c2ncnc3[nH]nc(Br)c23)CC1 CHEMBL2016893 IC50 2.0 nM
NC(=O)c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3949501 IC50 2.0 nM
Cc1cc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4C(N)=O)CC3)n2)ccc1F CHEMBL3972162 IC50 2.0 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2C2CCNCC2)CC1 CHEMBL3915684 IC50 2.0 nM
CNCCn1cc(-c2ccnc(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2Cl)CC1 CHEMBL3948454 IC50 2.0 nM
Cc1cc(-c2cn(CC3CNC3)c(C3CCN(c4ncnc(N)c4OCC(F)(F)F)CC3)n2)ccc1F CHEMBL3976254 IC50 2.0 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(F)c3)cn2CCN2CCCC2)CC1 CHEMBL3890225 IC50 2.0 nM
NC(=O)c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(OC(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3954717 IC50 2.0 nM
CC(C)(C)NCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C(N)=O)CC1 CHEMBL3904852 IC50 2.0 nM
CCC(C)(C)NCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C(N)=O)CC1 CHEMBL3983708 IC50 2.0 nM
CN(C)CCOC(c1ccc(F)cc1)C1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1 CHEMBL3957511 IC50 2.0 nM
NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3ccc(Cl)c(F)c3)ncnc12 CHEMBL4856439 IC50 2.0 nM
CCc1nc(N[C@H](CNC)c2cccc(F)c2)c2cccc(C(N)=O)c2n1 CHEMBL4869229 IC50 2.0 nM
CNC[C@@H](Nc1nc(C)nc2c(C(N)=O)cccc12)c1cccc(F)c1 CHEMBL4854144 IC50 2.0 nM
NC(=O)c1cccc2c(NCc3ccc(C(F)(F)F)cc3)ncnc12 CHEMBL3675355 IC50 2.0 nM
CNCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(OC)cc2F)c1 CHEMBL3675427 IC50 2.1 nM
CC1CCCN1c1cc(C(=O)Nc2cccc(C(CN(C)C)Nc3ncnc4c(C(N)=O)cccc34)c2)ccn1 CHEMBL3675428 IC50 2.1 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2Br)CC1 CHEMBL3917944 IC50 2.1 nM
COc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2C)CC1 CHEMBL3964789 IC50 2.1 nM
Cc1ncc(-c2c(N)ncnc2N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3C)CC2)s1 CHEMBL3922417 IC50 2.1 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(OC(F)F)cc3)cn2CCN2CCC2)CC1 CHEMBL3970397 IC50 2.1 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CC2CNC2)CC1 CHEMBL3967750 IC50 2.1 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3922798 IC50 2.1 nM
CCOc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCNC(C)C)CC1 CHEMBL3912471 IC50 2.1 nM
CNC[C@@H](Nc1ncnc2c(C(N)=O)cc(OC)cc12)c1ccccc1 CHEMBL3675429 IC50 2.2 nM
Cc1ccc(-c2c(N)ncnc2N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3C)CC2)cn1 CHEMBL3901580 IC50 2.2 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2CO)CC1 CHEMBL3927385 IC50 2.2 nM
CN(C)CCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2Br)CC1 CHEMBL3961106 IC50 2.2 nM
COc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3954017 IC50 2.2 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(OC)c3)cn2CCN2CCC2)CC1 CHEMBL3935483 IC50 2.2 nM
NC(=O)c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CC2CNC2)CC1 CHEMBL3942663 IC50 2.2 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CC2CNC2)CC1 CHEMBL3892286 IC50 2.2 nM
CCOc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CC2CNC2)CC1 CHEMBL3943569 IC50 2.2 nM
Nc1ncnc(N2CCC(c3nc(-c4cccc(C(F)(F)F)c4)cn3CCN3CCCC3)CC2)c1Br CHEMBL3906488 IC50 2.2 nM
CC(C)N(C)CCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3909180 IC50 2.2 nM
NCC(c1ccc(C(F)(F)F)cc1)N1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1 CHEMBL3982464 IC50 2.2 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2ccc(N)nc2)CC1 CHEMBL3904694 IC50 2.3 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2cccnc2)CC1 CHEMBL3958964 IC50 2.3 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3cccc(OC(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3980688 IC50 2.3 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)cc3)cn2CCN2CCCC2)CC1 CHEMBL3894577 IC50 2.3 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3cccc(C(F)(F)F)c3)cn2CCN2CCCC2)CC1 CHEMBL3896892 IC50 2.3 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3cccc(Cl)c3)cn2CCN2CCCC2)CC1 CHEMBL3918965 IC50 2.3 nM
Cc1cc(-c2cn(CCN3CCCC3)c(C3CCN(c4ncnc(N)c4C(N)=O)CC3)n2)ccc1F CHEMBL3905309 IC50 2.3 nM
CCN(CC)C1CCN(c2cc(C(=O)Nc3cccc(C(CN(C)C)Nc4ncnc5c(C(N)=O)cccc45)c3)ccn2)C1 CHEMBL3675430 IC50 2.4 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)c[nH]3)CC2)c1-c1ccc(F)cc1 CHEMBL3979925 IC50 2.4 nM
CCOc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3932390 IC50 2.4 nM
CCOc1c(N)ncnc1N1CCC(c2nc(-c3ccnc(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3959379 IC50 2.4 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccnc(F)c3)cn2CCN2CCC2)CC1 CHEMBL3932866 IC50 2.4 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1-c1ccc(F)cc1 CHEMBL3903522 IC50 2.4 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3cccc(Cl)c3)cn2CCN2CCC2)CC1 CHEMBL3939097 IC50 2.4 nM
CCOc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CCN(CC)CC)CC1 CHEMBL3986943 IC50 2.4 nM
Cc1cc(-c2cn(CCNC(C)C)c(C3CCN(c4ncnc(N)c4C(N)=O)CC3)n2)ccc1F CHEMBL3975681 IC50 2.4 nM
NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3cccc(F)c3)ncnc12 CHEMBL4851020 IC50 2.4 nM
COC/C=C/c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2C)CC1 CHEMBL3889930 IC50 2.5 nM
C=Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCCC2)CC1 CHEMBL3932421 IC50 2.5 nM
CNCCn1cc(-c2ccc(F)c(C)c2)nc1C1CCN(c2ncnc(N)c2C(N)=O)CC1 CHEMBL3940462 IC50 2.5 nM
Cc1cc(-c2cn(CC3CN(CO)C3)c(C3CCN(c4ncnc(N)c4C(C)C)CC3)n2)ccc1F CHEMBL3974777 IC50 2.5 nM
Nc1ncnc(N2CCC(C(O)c3ccc(Cl)cc3)CC2)c1-c1ccc(F)cc1 CHEMBL3964354 IC50 2.5 nM
Fc1cnc(Nc2ccccc2)nc1Nc1ccccc1 CHEMBL491758 pKi 2.512 nM
COc1ccc(C(=O)Nc2cccc(C(CN(C)C)Nc3ncnc4c3=CCCC=4C(N)=O)c2)cc1F CHEMBL3675431 IC50 2.6 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C(N)=O)CC1 CHEMBL3964726 IC50 2.6 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccsc3)cn2CCN2CCC2)CC1 CHEMBL3970947 IC50 2.6 nM
C=Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3931504 IC50 2.6 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(Cl)c(F)c3)cn2CCN2CCCC2)CC1 CHEMBL3977596 IC50 2.6 nM
CCOc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN(C)C)CC1 CHEMBL3976247 IC50 2.6 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)cc3)cn2CCN2CCCC2)CC1 CHEMBL3899172 IC50 2.6 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3cccc(F)c3)cn2CCN2CCCC2)CC1 CHEMBL3968052 IC50 2.6 nM
COc1ccc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)cc1F CHEMBL3948379 IC50 2.6 nM
NC[C@H](c1ccc(C(F)(F)F)cc1)N1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1 CHEMBL4110986 IC50 2.6 nM
NC[C@@H](c1ccc(Cl)nc1)N1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1 CHEMBL3934983 IC50 2.6 nM
Nc1ncnc(N2CCC(N)(CNC(=O)c3ccc(F)cc3F)C2)c1-c1cccc(F)c1 CHEMBL3964273 IC50 2.6 nM
CN(C)C[C@@H](Nc1ncnc2c(C(N)=O)cccc12)c1ccccc1 CHEMBL3675442 IC50 2.6 nM
COc1cc(C(N)=O)c2ncnc(NCc3ccc(Cl)c(Cl)c3)c2c1 CHEMBL3670494 IC50 2.7 nM
C[C@@H](Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(C(F)(F)F)cc2F)c1 CHEMBL3675432 IC50 2.7 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2ccc(C#N)cc2)CC1 CHEMBL3897066 IC50 2.7 nM
COc1ccc(-c2c(N)ncnc2N2CCC(c3nc(-c4cccc(C(F)(F)F)c4)c[nH]3)CC2)cc1 CHEMBL3926334 IC50 2.7 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2cncnc2)CC1 CHEMBL3929608 IC50 2.7 nM
C=Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN(C)C)CC1 CHEMBL3931848 IC50 2.7 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccnc(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3920419 IC50 2.7 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2C2CCNC2)CC1 CHEMBL3935986 IC50 2.7 nM
CCN(CC)CCn1cc(-c2ccc(F)c(C)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3896910 IC50 2.7 nM
NC(=O)c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCNCC2CC2)CC1 CHEMBL3900963 IC50 2.7 nM
CCNC[C@@H](Nc1ncnc2c(C(N)=O)cc(OC)cc12)c1ccccc1 CHEMBL3675433 IC50 2.8 nM
COc1cc(C(N)=O)c2ncnc(N[C@H](CN(C)C)c3cccc(F)c3)c2c1 CHEMBL3675434 IC50 2.8 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCCCC3)CC2)c1Br CHEMBL3956468 IC50 2.8 nM
COc1c(N)ncnc1N1CCC(c2nc(-c3ccnc(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3890310 IC50 2.8 nM
Cc1cc(-c2cn(CCNC(C)(C)C)c(C3CCN(c4ncnc(N)c4-c4cn[nH]c4)CC3)n2)ccc1F CHEMBL3970663 IC50 2.8 nM
Nc1ncnc(N2CCC(c3nc(-c4ccnc(C(F)(F)F)c4)cn3CCNC3CC3)CC2)c1Cl CHEMBL3931731 IC50 2.8 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCC(F)(F)C2)CC1 CHEMBL3973744 IC50 2.8 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCCCC2)CC1 CHEMBL3899177 IC50 2.8 nM
Cc1cc(-c2cn(CCN3CCCC3)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)ccc1F CHEMBL3972635 IC50 2.8 nM
Cc1cc(-c2cn(CCO)c(C3CCN(c4ncnc(N)c4C(N)=O)CC3)n2)ccc1F CHEMBL3897830 IC50 2.8 nM
NCC(c1ccc(C(F)(F)F)cc1)N1CCN(c2ncnc(N)c2-c2cn[nH]c2)CC1 CHEMBL3936890 IC50 2.8 nM
CCNC[C@@H](Nc1ncnc2c1=CCCC=2C(N)=O)c1cccc(F)c1 CHEMBL3675435 IC50 2.9 nM
Nc1ncnc(N2CCC(c3nc(-c4ccnc(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1-c1cnoc1 CHEMBL3908552 IC50 2.9 nM
C=Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)cc3)cn2CCN2CCCC2)CC1 CHEMBL3974191 IC50 2.9 nM
CC(C)CNCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C(N)=O)CC1 CHEMBL3919344 IC50 2.9 nM
NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3ccc(F)c(C(F)(F)F)c3)ncnc12 CHEMBL4846712 IC50 2.9 nM
CNCC(Nc1ncnc2c(C(N)=O)cccc12)c1ccccc1 CHEMBL3670413 IC50 2.9 nM
Cc1ccc(Cl)cc1N1CCN(c2ncnc(N)c2[N+](=O)[O-])CC1 CHEMBL2012584 IC50 3.0 nM
CCc1n[nH]c2ncnc(N3CCN(c4cc(Cl)cc(CCCN(CC)CC)c4C)CC3)c12 CHEMBL2012695 IC50 3.0 nM
CCc1n[nH]c2ncnc(N3CCN(c4cc(Cl)cc(NCCN(CC)CC)c4C)CC3)c12 CHEMBL2012696 IC50 3.0 nM
CCc1n[nH]c2ncnc(N3CCN(c4cc(Cl)cc(NCCN5CCCC5)c4C)CC3)c12 CHEMBL2012699 IC50 3.0 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2ccccc2F)CC1 CHEMBL3935451 IC50 3.0 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2ccc(F)nc2)CC1 CHEMBL3978888 IC50 3.0 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncncc2Br)CC1 CHEMBL3892829 IC50 3.0 nM
CN(C)CCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2ccncc2)CC1 CHEMBL3895298 IC50 3.0 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CC(C)C2)CC1 CHEMBL3963881 IC50 3.0 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1-c1cn[nH]c1 CHEMBL3927188 IC50 3.0 nM
NC(=O)c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2C2CCNCC2)CC1 CHEMBL3968856 IC50 3.0 nM
N#CC[C@@H](Nc1ncnc2c(C(N)=O)cccc12)c1ccccc1 CHEMBL3670414 IC50 3.1 nM
COc1cc(C(N)=O)c2ncnc(NCc3cccc(C(F)(F)F)c3)c2c1 CHEMBL3670460 IC50 3.1 nM
CN(C)CCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C2=CCCC2)CC1 CHEMBL3950150 IC50 3.1 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccnc(Cl)c3)cn2CCN2CCC2)CC1 CHEMBL3923440 IC50 3.1 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCCC3)CC2)c1Cl CHEMBL3986793 IC50 3.1 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CCN(CC)C(C)C)CC1 CHEMBL3968774 IC50 3.1 nM
CCn1c(-c2nonc2N)nc2cnc(Oc3cccc(NC(=O)c4ccc(OCCN5CCOCC5)cc4)c3)cc21 CHEMBL220241 pKi 3.162 nM
C=CCN(C)CCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(Br)cc2)c1 CHEMBL3675436 IC50 3.2 nM
CN(C)CCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C2CC2)CC1 CHEMBL3900512 IC50 3.2 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCCC2)CC1 CHEMBL3927440 IC50 3.2 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3cccc(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3921412 IC50 3.2 nM
NC[C@H](c1ccc(C(F)(F)F)cc1)C1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1 CHEMBL4114630 IC50 3.2 nM
COc1ccc(C(=O)Nc2cccc([C@@H](C)Nc3ncnc4c(C(N)=O)cccc34)c2)cn1 CHEMBL3675437 IC50 3.3 nM
CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc3c(c2)OCO3)c1 CHEMBL3675438 IC50 3.3 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(Cl)c(F)c4)cn3CCN3CCCC3)CC2)c1Br CHEMBL3968655 IC50 3.3 nM
Cc1cc(-c2cn(CCNCC3CC3)c(C3CCN(c4ncnc(N)c4C(N)=O)CC3)n2)ccc1F CHEMBL3974713 IC50 3.3 nM
NCC(c1ccc(C(F)(F)F)cc1)C1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1 CHEMBL3911701 IC50 3.3 nM
Nc1ncnc(N2CCC(N)(CNC(=O)c3ccc(F)cc3F)C2)c1Br CHEMBL3917646 IC50 3.3 nM
COc1cccc(C(CN)Nc2ncnc3c(C(N)=O)cccc23)c1 CHEMBL3670411 IC50 3.4 nM
CC(C)c1cc(C(=O)Nc2cccc([C@@H](C)Nc3ncnc4c(C(N)=O)cccc34)c2)[nH]n1 CHEMBL3675439 IC50 3.4 nM
CN(CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc([N+](=O)[O-])c1)C(=O)OC(C)(C)C CHEMBL3675440 IC50 3.4 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1 CHEMBL3925871 IC50 3.4 nM
Cc1cc(-c2cn(CC3CNC3)c(C3CCN(c4ncnc(N)c4OC(C)C)CC3)n2)ccc1F CHEMBL3987123 IC50 3.4 nM
Cc1cc(-c2cn(CC3CNC3)c(C3CCC(c4ncnc(N)c4C(C)C)CC3)n2)ccc1F CHEMBL3899097 IC50 3.4 nM
CC(C)Oc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN(C)C)CC1 CHEMBL3905494 IC50 3.4 nM
COCCN(C)CCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3974022 IC50 3.4 nM
CNCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C(N)=O)CC1 CHEMBL3967166 IC50 3.4 nM
NC[C@H](c1ccc(C(F)(F)F)cc1)N1CCN(c2ncnc(N)c2-c2cn[nH]c2)CC1 CHEMBL4110173 IC50 3.4 nM
NCC(c1ccc(C(F)(F)F)cc1)N1CCN(c2ncnc(N)c2C2=CCCC2)CC1 CHEMBL3932608 IC50 3.4 nM
COc1ccc(C(CN)N2CCN(c3ncnc(N)c3-c3ccc(F)cc3)CC2)cn1 CHEMBL3906331 IC50 3.4 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(F)cc4F)c3)ncnc12 CHEMBL3675441 IC50 3.5 nM
CN(C)CCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C(N)=O)CC1 CHEMBL3936329 IC50 3.5 nM
COC(=O)/C=C/c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2C)CC1 CHEMBL3951912 IC50 3.5 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCCC3)CC2)c1Br CHEMBL3982415 IC50 3.5 nM
CN(C)CCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2ccc(N)nc2)CC1 CHEMBL3973946 IC50 3.5 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3cccc(C(F)(F)F)c3)cn2CCN2CCCC2)CC1 CHEMBL3982706 IC50 3.5 nM
NC(=O)c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCCCC2)CC1 CHEMBL3980207 IC50 3.5 nM
CCOc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CCO)CC1 CHEMBL3924930 IC50 3.5 nM
CC(C)c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3917410 IC50 3.6 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3cccc(F)c3)cn2CCN2CCCC2)CC1 CHEMBL3969229 IC50 3.6 nM
NC(=O)c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(Cl)c3)cn2CCN2CCCC2)CC1 CHEMBL3973734 IC50 3.6 nM
CC(C)NCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3924599 IC50 3.6 nM
CC1CC=C(C(=O)Nc2cccc(C(C)Nc3ncnc4c(C(N)=O)cccc34)c2)C=C1F CHEMBL3675443 IC50 3.7 nM
CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(F)c(O)c2)c1 CHEMBL3675444 IC50 3.7 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2ccccc2)CC1 CHEMBL3973975 IC50 3.7 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCCC3)CC2)c1-c1ccccc1F CHEMBL3944868 IC50 3.7 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN(C)C)CC1 CHEMBL3911401 IC50 3.7 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(O)c(C(F)(F)F)c4)cn3CCN3CCCC3)CC2)c1Cl CHEMBL3961556 IC50 3.7 nM
NC(=O)c1c(N)ncnc1N1CCC(c2nc(-c3ccnc(C4CC4)c3)cn2CCN2CCC2)CC1 CHEMBL3941240 IC50 3.7 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CC2CCN2)CC1 CHEMBL3906193 IC50 3.8 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCCCC3)CC2)c1Cl CHEMBL3938237 IC50 3.8 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(F)c3)cn2CCN2CCC2)CC1 CHEMBL3912123 IC50 3.8 nM
CC(C)c1cc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4C(N)=O)CC3)n2)ccn1 CHEMBL3928144 IC50 3.8 nM
CN(C)CCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(F)cc2F)c1 CHEMBL3675445 IC50 3.9 nM
Cc1cc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4OC(C)C)CC3)n2)ccc1F CHEMBL3985943 IC50 3.9 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(Cl)c3)cn2CCN2CCC2)CC1 CHEMBL3985540 IC50 3.9 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CCN2CCCC2)CC1 CHEMBL3975180 IC50 3.9 nM
Cc1ccc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4C(N)=O)CC3)n2)cc1Cl CHEMBL3927542 IC50 3.9 nM
FC(F)(F)c1ccc(Cn2cc(-c3ccc4[nH]ncc4c3)nn2)c(C(F)(F)F)c1 CHEMBL1964413 pKi 3.981 nM
Nc1nonc1-c1nc2ccccc2n1C1CCC1 CHEMBL1079294 Ki 4.0 nM
Cc1c(NCCN(C)C)cc(Cl)cc1N1CCN(c2ncnc3[nH]nc(C(F)(F)F)c23)CC1 CHEMBL2012703 IC50 4.0 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(Cl)cc4Cl)c3)ncnc12 CHEMBL3675446 IC50 4.0 nM
CCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(OC)nc2)c1 CHEMBL3675447 IC50 4.0 nM
CNCC(Nc1ncnc2c1=CCCC=2C(N)=O)c1cccc(NC(=O)c2ccc(C(F)(F)F)cc2)c1 CHEMBL3675448 IC50 4.0 nM
Nc1ncnc(N2CCC(c3nc(-c4cccc(F)c4)cn3CCN3CCCC3)CC2)c1C1CCC1 CHEMBL3969159 IC50 4.0 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(Cl)c4)cn3CCN3CCCC3)CC2)c1C1CCC1 CHEMBL3952378 IC50 4.0 nM
Cc1ccc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4C(N)=O)CC3)n2)cc1C(F)(F)F CHEMBL3920410 IC50 4.0 nM
Cc1cc(-c2cn(CCN(C)C)c(C3CCN(c4ncnc(N)c4C(N)=O)CC3)n2)ccc1F CHEMBL3977710 IC50 4.0 nM
COCCNCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C(N)=O)CC1 CHEMBL3957688 IC50 4.0 nM
Cc1cc(-c2cn(CCNC3CCCC3)c(C3CCN(c4ncnc(N)c4C(N)=O)CC3)n2)ccc1F CHEMBL3934916 IC50 4.0 nM
NCC(c1ccc(F)c(Cl)c1)N1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1 CHEMBL3915352 IC50 4.0 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc3[nH]ncc23)CC1 CHEMBL3545076 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cccc([C@@H](C)Nc3ncnc4c(C(N)=O)cccc34)c2)cn1 CHEMBL3639743 IC50 4.1 nM
CN(C)CCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(C(F)(F)F)cc2)c1 CHEMBL3675449 IC50 4.1 nM
NC(=O)c1ccc(NC2CNCCC2c2ccccc2)c2cncnc12 CHEMBL3945578 IC50 4.1 nM
Nc1ncnc(N2CCC(c3nc(-c4cccc(Cl)c4)cn3CCN3CCCC3)CC2)c1C1CCC1 CHEMBL3957616 IC50 4.1 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CCN(C)C)CC1 CHEMBL3960833 IC50 4.1 nM
CN(C)CCN(C)CCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3912087 IC50 4.1 nM
NCC(c1cccc(F)c1)N1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1 CHEMBL3972358 IC50 4.1 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2ccc(CN)cc2)CC1 CHEMBL3941799 IC50 4.2 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CC(F)C2)CC1 CHEMBL3890270 IC50 4.2 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1OCC(F)(F)F CHEMBL3895450 IC50 4.2 nM
Nc1ncnc(N2CCN(C(CN3CCC3)c3ccc(C(F)(F)F)cc3)CC2)c1-c1ccc(F)cc1 CHEMBL3948645 IC50 4.2 nM
COc1cncc(-c2c(N)ncnc2N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3C)CC2)c1 CHEMBL3939318 IC50 4.3 nM
COCCC(Nc1ncnc2c(C(N)=O)cccc12)C1=CCCC(NC(=O)c2ccc(F)cc2F)=C1 CHEMBL3675450 IC50 4.4 nM
CN(C)CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc([N+](=O)[O-])c1 CHEMBL3675451 IC50 4.4 nM
NC(=O)c1cccc2c(NCCc3c[nH]c4ccccc34)ncnc12 CHEMBL3675452 IC50 4.4 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2cnc(N)nc2)CC1 CHEMBL3949829 IC50 4.4 nM
Cc1cc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4-c4cn[nH]c4)CC3)n2)ccc1F CHEMBL3922949 IC50 4.4 nM
C=Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(C(F)(F)F)c(F)c3)cn2CCN2CCCC2)CC1 CHEMBL3964344 IC50 4.4 nM
NCC(c1ccc(F)cc1)N1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1 CHEMBL3920854 IC50 4.4 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4cncc(N5CCCC5)c4)c3)ncnc12 CHEMBL3675453 IC50 4.5 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2ccc(Cl)nc2)CC1 CHEMBL3902751 IC50 4.5 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3cncc(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3951221 IC50 4.5 nM
NC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1 CHEMBL3903649 IC50 4.5 nM
NC[C@@H](c1ccc(C(F)(F)F)cc1)C1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1 CHEMBL3935973 IC50 4.5 nM
COc1cc(C(N)=O)c2ncnc(NCc3ccc(C(F)(F)F)cc3)c2c1 CHEMBL3670486 IC50 4.6 nM
CN(C)CC(Nc1ncnc2c(C(N)=O)cc(OCC3CC3)cc12)c1cccc(F)c1 CHEMBL3675454 IC50 4.6 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3cccc(F)c3)cn2CCN2CCC2)CC1 CHEMBL3894252 IC50 4.6 nM
CCN(CC)CCn1cc(-c2ccc(F)c(C)c2)nc1C1CCN(c2ncnc(N)c2OC(C)C)CC1 CHEMBL3913659 IC50 4.6 nM
NC(=O)c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCCC2)CC1 CHEMBL3955767 IC50 4.6 nM
Nc1ncnc(N2CCC(C(O)c3ccc(F)cc3)CC2)c1-c1ccc(F)cc1 CHEMBL3930957 IC50 4.6 nM
COc1ccc(-c2c(N)ncnc2N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3C)CC2)cc1 CHEMBL3985874 IC50 4.7 nM
NC[C@@H](c1ccc(C(F)(F)F)cc1)C1CCN(c2ncnc(N)c2-c2cn[nH]c2)CC1 CHEMBL3905652 IC50 4.7 nM
Cc1ccc(C(=O)Nc2cccc([C@@H](C)Nc3ncnc4c(C(N)=O)cccc34)c2)cc1C CHEMBL3675455 IC50 4.8 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CC3CNC3)CC2)c1Cl CHEMBL3897233 IC50 4.8 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CC3CCN3)CC2)c1Cl CHEMBL3896152 IC50 4.8 nM
Nc1ncnc(N2CCC(N)(CNC(=O)c3ccc(F)cc3F)C2)c1-c1ccc(F)cc1 CHEMBL3929477 IC50 4.8 nM
CNCC(Nc1ncnc2c(C(N)=O)cc(OCc3ccccc3)cc12)c1cccc(Cl)c1 CHEMBL3675456 IC50 4.9 nM
CC(C)Oc1c(N)ncnc1N1CCC(c2nc(-c3ccnc(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3927446 IC50 4.9 nM
CN1CC(Cn2cc(-c3ccc(F)c(C(F)(F)F)c3)nc2C2CCN(c3ncnc(N)c3C(N)=O)CC2)C1 CHEMBL3977344 IC50 4.9 nM
CN(C)CC(c1ccc(C(F)(F)F)cc1)N1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1 CHEMBL3928625 IC50 4.9 nM
CN(C)C[C@H](c1ccc(C(F)(F)F)cc1)N1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1 CHEMBL4111671 IC50 4.9 nM
CCc1n[nH]c2ncnc(N3CCN(c4cc(Cl)cc(OCCN5CCCC5)c4C)CC3)c12 CHEMBL2012697 IC50 5.0 nM
C[C@@H](Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2cc(C(F)(F)F)ccc2F)c1 CHEMBL3675457 IC50 5.0 nM
CN(CCO)c1cc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)ccn1 CHEMBL3675458 IC50 5.0 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2ccc(C#N)c(F)c2)CC1 CHEMBL3898856 IC50 5.0 nM
C=C(C)c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN(C)C)CC1 CHEMBL3954073 IC50 5.0 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 5.012 nM
CN(C)CCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(Br)cc2)c1 CHEMBL3675459 IC50 5.1 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCCCC3)CC2)c1-c1ccccc1F CHEMBL3977191 IC50 5.1 nM
C[C@@H](Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(C#N)nc2)c1 CHEMBL3675460 IC50 5.2 nM
CCOCCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN(C)C)CC1 CHEMBL3901997 IC50 5.2 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CC2CCN2)CC1 CHEMBL3961268 IC50 5.2 nM
CCN(CCn1cc(-c2ccc(F)c(C)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1)C(C)C CHEMBL3957053 IC50 5.2 nM
NCC(c1ccc(C(F)(F)F)cc1)C1CCN(c2ncnc(N)c2-c2cn[nH]c2)CC1 CHEMBL3933677 IC50 5.2 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2ccccc2Cl)CC1 CHEMBL3907506 IC50 5.3 nM
CC(C)Oc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3904712 IC50 5.3 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(C(F)(F)F)c(F)c3)cn2CCN2CC[C@H](F)C2)CC1 CHEMBL3889695 IC50 5.3 nM
NCC(c1ccc(C(F)(F)F)cc1)N1CCN(c2ncnc(N)c2C2=CCCCC2)CC1 CHEMBL3947951 IC50 5.3 nM
Nc1ncnc(N2CCC(N)(CNC(=O)c3ccc(F)cc3F)C2)c1-c1ccccc1 CHEMBL3913380 IC50 5.3 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncncc2-c2ccc(F)cc2)CC1 CHEMBL3968301 IC50 5.4 nM
C=Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCCCC2)CC1 CHEMBL3972216 IC50 5.5 nM
NC(=O)c1c(N)ncnc1N1CCC(c2nc(-c3ccnc(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3956421 IC50 5.5 nM
CCOc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CC2CNC2)CC1 CHEMBL3900660 IC50 5.5 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(F)c3)cn2CCN2CCOCC2)CC1 CHEMBL3971381 IC50 5.5 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(C(F)(F)F)c(F)c3)cn2CCN2CCC(F)(F)CC2)CC1 CHEMBL3913067 IC50 5.5 nM
CC(C)(C)c1cc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4C(N)=O)CC3)n2)ccn1 CHEMBL3918747 IC50 5.5 nM
Cc1cc(-c2cn(CCNCC(C)C)c(C3CCN(c4ncnc(N)c4C(N)=O)CC3)n2)ccc1F CHEMBL3974261 IC50 5.5 nM
CN(C)CCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2cnc(N)nc2)CC1 CHEMBL3922652 IC50 5.6 nM
COc1ccccc1C(CN)Nc1ncnc2c(C(N)=O)cccc12 CHEMBL3675329 IC50 5.7 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccccc3)cn2CCN2CCC2)CC1 CHEMBL3931262 IC50 5.7 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1-c1ccc(C(=O)O)cc1 CHEMBL3901741 IC50 5.7 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(C(F)(F)F)c(F)c3)cn2CCN2CCCC(F)C2)CC1 CHEMBL3976022 IC50 5.7 nM
NC[C@@H](c1ccc(C(F)(F)F)cc1)N1CCN(c2ncnc(N)c2-c2cn[nH]c2)CC1 CHEMBL3892901 IC50 5.7 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCCC3)CC2)c1-c1ccc(C(=O)O)cc1 CHEMBL3960331 IC50 5.8 nM
NCC(c1ccc(C(F)(F)F)cc1)N1CCN(c2ncnc(N)c2Br)CC1 CHEMBL3957113 IC50 5.8 nM
NCC(c1ccc(C(F)(F)F)cc1)N1CCN(c2ncnc(N)c2-c2cc[nH]c2)CC1 CHEMBL3918502 IC50 5.8 nM
COc1ncc(C(=O)Nc2cccc([C@@H](C)Nc3ncnc4c(C(N)=O)cccc34)c2)cc1Cl CHEMBL3675461 IC50 5.9 nM
NC(=O)c1ccc(NC2CNCCC2c2ccc(C(F)(F)F)c(F)c2)c2cncnc12 CHEMBL3952085 IC50 5.9 nM
CNCCn1cc(-c2ccc(F)c(C)c2)nc1C1CCN(c2ncnc(N)c2-c2cn[nH]c2)CC1 CHEMBL3913969 IC50 5.9 nM
CC(C)Oc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CC2CNC2)CC1 CHEMBL3925183 IC50 5.9 nM
Nc1ncnc(N2CC[C@@](N)(CNC(=O)c3ccc(F)cc3F)C2)c1-c1ccc(F)cc1 CHEMBL4108932 IC50 5.9 nM
CCc1n[nH]c2ncnc(N3CCN(c4cc(Cl)ccc4C)CC3)c12 CHEMBL2012592 IC50 6.0 nM
CCCc1n[nH]c2ncnc(N3CCN(c4cc(Cl)ccc4C)CC3)c12 CHEMBL2012594 IC50 6.0 nM
CCc1n[nH]c2ncnc(N3CCN(c4cc(Cl)cc(OCCN(C)C)c4C)CC3)c12 CHEMBL2012700 IC50 6.0 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(C3CCCCC3)cn2CCN2CCC2)CC1 CHEMBL3925234 IC50 6.0 nM
NC(=O)c1c(N)ncnc1N1CCC(c2nc(-c3ccsc3)cn2CCN2CCC2)CC1 CHEMBL3922482 IC50 6.0 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(C(F)(F)F)c(F)c4)cn3CCN3CCC3)CC2)c1C1CCC1 CHEMBL3948660 IC50 6.0 nM
Cn1cc(-c2c(N)ncnc2N2CCN([C@@H](CN)c3ccc(C(F)(F)F)cc3)CC2)cn1 CHEMBL3929706 IC50 6.0 nM
NCC(c1ccc(Cl)c(Cl)c1)N1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1 CHEMBL3928221 IC50 6.0 nM
Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCCC2)CC1 CHEMBL3910308 IC50 6.1 nM
NCC(c1ccc(Cl)c(F)c1)N1CCN(c2ncnc(N)c2-c2cn[nH]c2)CC1 CHEMBL3955537 IC50 6.1 nM
Nc1ncnc(N2CCC(c3nc(-c4cccc(C(F)(F)F)c4)c[nH]3)CC2)c1Br CHEMBL3926903 IC50 6.2 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(C(F)(F)F)cc4)cn3CCN3CCCC3)CC2)c1Br CHEMBL3897494 IC50 6.2 nM
Cc1cc(-c2cn(CCN(C)C(C)C)c(C3CCN(c4ncnc(N)c4C(N)=O)CC3)n2)ccc1F CHEMBL3946371 IC50 6.2 nM
NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3ccccc3)ncnc12 CHEMBL4878044 IC50 6.2 nM
C[C@@H](Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2cc(C(C)(C)C)n[nH]2)c1 CHEMBL3675462 IC50 6.3 nM
COc1cc(C(=O)Nc2cccc([C@@H](C)Nc3ncnc4c(C(N)=O)cccc34)c2)ccn1 CHEMBL3675463 IC50 6.3 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2ccc(F)c(F)c2)CC1 CHEMBL3912513 IC50 6.3 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)cc3)cn2CCN2CC3(COC3)C2)CC1 CHEMBL3909262 IC50 6.3 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(C(F)(F)F)c(F)c4)cn3CCN3CCCC3)CC2)c1Br CHEMBL3950518 IC50 6.3 nM
Nc1ncnc(N2CCC(c3nc(-c4cccc(C(F)(F)F)c4)cn3CCN3CCCC3)CC2)c1C1CCC1 CHEMBL3981168 IC50 6.3 nM
CN(C)CCN(C)CCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C(N)=O)CC1 CHEMBL3963052 IC50 6.3 nM
NCC(c1ccccc1)N1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1 CHEMBL3890900 IC50 6.3 nM
NC(COc1cncc(-c2cc3ccncc3s2)c1)Cc1c[nH]c2ccccc12 CHEMBL1966524 pKi 6.31 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2C2CNC2)CC1 CHEMBL3891763 IC50 6.4 nM
CC(C)N(C)CCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C(N)=O)CC1 CHEMBL3976678 IC50 6.4 nM
N=C(N)NCCC[C@@H](NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)CCCCCNCCNS(=O)(=O)c1cccc2cnccc12)C(N)=O CHEMBL2023714 pIC50 6.457 nM
C[C@@H](Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc3c(c2)OCO3)c1 CHEMBL3675464 IC50 6.5 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)cc4)cn3CCN3CCCC3)CC2)c1C1CCC1 CHEMBL3892575 IC50 6.5 nM
NC(=O)c1cccc2c(NCc3ccc(Br)cc3)ncnc12 CHEMBL3670415 IC50 6.6 nM
CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2cc(C(C)(C)C)n[nH]2)c1 CHEMBL3675465 IC50 6.6 nM
CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)C2=CCC(Br)C=C2)c1 CHEMBL3675466 IC50 6.6 nM
CN(CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccccc2)c1)C(=O)OC(C)(C)C CHEMBL3675467 IC50 6.6 nM
Cc1cc(-c2cn(CCO)c(C3CCN(c4ncnc(N)c4-c4cn[nH]c4)CC3)n2)ccc1F CHEMBL3900157 IC50 6.7 nM
C=C(C)c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCCCC2)CC1 CHEMBL3923786 IC50 6.7 nM
COc1cccc(C(CN(C)C)Nc2ncnc3c(C(N)=O)cccc23)c1 CHEMBL3675468 IC50 6.8 nM
CCOc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CCN2CCCC2)CC1 CHEMBL3900809 IC50 6.8 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(F)c4)cn3CCN3CCCC3)CC2)c1C1CCC1 CHEMBL3961562 IC50 6.9 nM
Cc1[nH]nc2ccc(-c3cc(OC[C@@H](N)Cc4c[nH]c5ccccc45)cnc3-c3ccoc3)cc12 CHEMBL593490 IC50 7.0 nM
Cc1ccc(Cl)cc1N1CCN(c2ncnc3[nH]nc(Br)c23)CC1 CHEMBL2012595 IC50 7.0 nM
C=S(=O)(O)c1ccc2c(c1)C(C)(C)C1=[N+]2CCC2OC3CCN4C(=C3C=C12)C(C)(C)c1cc(CC(=O)NCCCC[C@@H](NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)CCCCCNC(=O)[C@@H](CCCNC(=N)N)NC(=O)CCCCCCCNCCNS(=O)(=O)c2cccc3cnccc23)C(N)=O)ccc14 CHEMBL2023841 Kd 7.0 nM
COCCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2c(F)cccc2F)c1 CHEMBL3675469 IC50 7.0 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CNCC[C@H]2c2ccc(F)c(F)c2)oc1Cl CHEMBL4457064 IC50 7.0 nM
Cc1cc(C(=O)Nc2cccc([C@@H](C)Nc3ncnc4c(C(N)=O)cccc34)c2)ccc1Cl CHEMBL3675470 IC50 7.1 nM
Cc1ccc(-c2c(N)ncnc2N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3C)CC2)s1 CHEMBL3940535 IC50 7.1 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CN[C@H](CCO)C[C@H]2c2ccc(F)c(F)c2)oc1Cl CHEMBL4441825 IC50 7.1 nM
CCOc1cc(C(N)=O)c2ncnc(NC(CN(C)C)c3cccc(F)c3)c2c1 CHEMBL3675471 IC50 7.2 nM
Nc1ncnc(N2CCN(Cc3ccc(C(F)(F)F)cc3)CC2)c1-c1ccc(F)cc1 CHEMBL3916166 IC50 7.2 nM
COc1cc(C(=O)Nc2cccc([C@@H](C)Nc3ncnc4c(C(N)=O)cccc34)c2)cnc1OC CHEMBL3675472 IC50 7.3 nM
Cc1ccc(-c2c(N)ncnc2N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3C)CC2)cc1 CHEMBL3980785 IC50 7.3 nM
CN(C)CCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1 CHEMBL3933645 IC50 7.3 nM
CN(C)CCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2ccc(C(=O)O)cc2)CC1 CHEMBL3979190 IC50 7.3 nM
CCNC[C@@H](Nc1ncnc2c(C(N)=O)cccc12)c1ccccc1 CHEMBL3675473 IC50 7.4 nM
Cc1cc(-c2cn(CC3CNC3)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)ccc1F CHEMBL3943038 IC50 7.4 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(Cl)cc3)cn2CCN2CCCC2)CC1 CHEMBL3945304 IC50 7.4 nM
CN(C)c1ncc(-c2c(N)ncnc2N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3C)CC2)cn1 CHEMBL3913809 IC50 7.5 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3cncc(Cl)c3)cn2CCN2CCC2)CC1 CHEMBL3907940 IC50 7.6 nM
NC(=O)c1c(N)ncnc1N1CCC(c2nc(-c3cccc(Cl)c3)cn2CCN2CCCC2)CC1 CHEMBL3942559 IC50 7.6 nM
C=C(C)c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCCC2)CC1 CHEMBL3901242 IC50 7.9 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(OC(F)(F)F)c4)c3)cc12 CHEMBL1965836 pKi 7.943 nM
COc1ccc(NC(=O)Nc2ccc(-c3cccc4onc(N)c34)cc2)cc1Cl CHEMBL272453 pKi 7.943 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CC(C)(C)N)cnc(N)c34)cc2)c1 CHEMBL1979577 pKi 7.943 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 8.0 nM
NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3ccc(F)cc3)ncnc12 CHEMBL4875416 IC50 8.0 nM
CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(Br)c(F)c2)c1 CHEMBL3675474 IC50 8.1 nM
COCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccccc2)c1 CHEMBL3675475 IC50 8.1 nM
NC(=O)c1ccc(NC2CNCCC2c2ccc(Cl)c(F)c2)c2cncnc12 CHEMBL3896518 IC50 8.1 nM
COC(=O)c1ccc(-c2c(N)ncnc2N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN(C)C)CC2)cc1 CHEMBL3937511 IC50 8.1 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(C(F)(F)F)c(F)c4)cn3CCN3CCCC3)CC2)c1C1CCC1 CHEMBL3915954 IC50 8.1 nM
NC(=O)c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(F)c3)cn2CCN2CCC2)CC1 CHEMBL3985709 IC50 8.1 nM
C[C@@H](Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2c(F)cccc2F)c1 CHEMBL3675476 IC50 8.2 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCCC3)CC2)c1-c1ccc(F)cc1 CHEMBL3916957 IC50 8.2 nM
COc1ccc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)cc1Cl CHEMBL3943041 IC50 8.3 nM
NC(=O)c1c(N)ncnc1N1CCC(c2nc(-c3ccccc3)cn2CCN2CCC2)CC1 CHEMBL3913487 IC50 8.4 nM
NCC(c1ccc(Cl)nc1)N1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1 CHEMBL3933781 IC50 8.5 nM
COc1cc(F)c(C(=O)Nc2cccc([C@@H](C)Nc3ncnc4c(C(N)=O)cccc34)c2)c(F)c1 CHEMBL3675477 IC50 8.6 nM
CCOC1CN(c2cc(N)ncn2)CCC1c1nc(-c2ccc(F)c(C)c2)cn1CCN(CC)C(C)C CHEMBL3975500 IC50 8.6 nM
NCC[C@@H](Nc1ncnc2c(C(N)=O)cccc12)c1ccccc1 CHEMBL3675478 IC50 8.7 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCCCC3)CC2)c1-c1cccc(F)c1 CHEMBL3947929 IC50 8.7 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccnc(C)c3)cn2CCN2CCC2)CC1 CHEMBL3965063 IC50 8.7 nM
CN(C)CC(Nc1ncnc2c(C(N)=O)cccc12)c1ccc(F)cc1 CHEMBL3675479 IC50 8.9 nM
CNC(=O)C[C@@H]1C[C@@H](c2ccc(F)c(F)c2)[C@H](NC(=O)c2cc(-c3c(Cl)cnn3C)c(Cl)o2)CN1 CHEMBL4440965 IC50 8.9 nM
Cc1ccc(Cl)cc1N1CCN(c2ncnc3[nH]nc(C)c23)CC1 CHEMBL2012591 IC50 9.0 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(Br)cc4)c3)ncnc12 CHEMBL3670468 IC50 9.0 nM
COCCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(C(F)(F)F)cc2)c1 CHEMBL3675480 IC50 9.0 nM
COc1ccc(C(=O)Nc2cccc(C(CN(C)C(=O)OC(C)(C)C)Nc3ncnc4c(C(N)=O)cccc34)c2)c(F)c1 CHEMBL3675481 IC50 9.0 nM
NCC(Cc1ccccc1)Nc1ncnc2c(C(N)=O)cccc12 CHEMBL3675482 IC50 9.0 nM
COc1ccc(-c2cnccc2N2CCC(c3nc(-c4cccc(C(F)(F)F)c4)c[nH]3)CC2)cc1 CHEMBL3899333 IC50 9.0 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(F)c3)cn2CCN2CCC3(COC3)C2)CC1 CHEMBL3926249 IC50 9.0 nM
COc1ccccc1N1CCN(c2ncnc3[nH]nc(Br)c23)CC1 CHEMBL1254209 IC50 9.1 nM
CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(C(F)(F)F)nc2)c1 CHEMBL3675483 IC50 9.1 nM
Nc1ncnc(N2CCC(N)(CNC(=O)c3ccc(F)cc3F)C2)c1-c1ccc(C(F)(F)F)cc1 CHEMBL3897935 IC50 9.1 nM
COc1ccc(C(=O)Nc2cccc(C(C)Nc3ncnc4c(C(N)=O)cccc34)c2)cn1 CHEMBL3675484 IC50 9.2 nM
COCCN(C)CCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C(N)=O)CC1 CHEMBL3897576 IC50 9.2 nM
CNCCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc([N+](=O)[O-])c1 CHEMBL3675485 IC50 9.3 nM
CN(C)CCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2ccc(C(C)(C)O)cc2)CC1 CHEMBL3904383 IC50 9.3 nM
CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(C#N)c(F)c2)c1 CHEMBL3675486 IC50 9.4 nM
CCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(C(F)(F)F)nc2)c1 CHEMBL3675487 IC50 9.4 nM
CN(CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(F)c(F)c2)c1)C(=O)OC(C)(C)C CHEMBL3675488 IC50 9.4 nM
CCNC[C@@H](Nc1ncnc2c(C(N)=O)cc(OC)cc12)c1cccc(F)c1 CHEMBL3675489 IC50 9.5 nM
COc1ccc(-c2c(N)ncnc2N2CCC(N)(CNC(=O)c3ccc(F)cc3F)C2)cn1 CHEMBL3963726 IC50 9.5 nM
Cc1nc(C)c(C(=O)Nc2cccc([C@@H](C)Nc3ncnc4c(C(N)=O)cccc34)c2)s1 CHEMBL3675490 IC50 9.6 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCCC3)CC2)c1-c1ccc(F)c(F)c1 CHEMBL3907965 IC50 9.6 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc5c(c4)OCO5)c3)ncnc12 CHEMBL3670471 IC50 9.7 nM
Nc1ncnc(N2CCC(c3nc(-c4ccnc(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1OCC(F)(F)F CHEMBL3965033 IC50 9.7 nM
COc1cccc(-c2c(N)ncnc2N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3C)CC2)c1 CHEMBL3906419 IC50 9.8 nM
NCC(c1ccc(C(F)(F)F)nc1)N1CCN(c2ncnc(N)c2-c2ccc(F)cc2)CC1 CHEMBL3942101 IC50 9.8 nM