N=C1N[C@@]23[C@H]([C@H]4NC(=N)N2C[C@](OS(=O)(=O)O)(C[C@H]2[C@@H](CO)CON2C4=O)C3(O)O)N1COC(=O)NO CHEMBL3617050 IC50 0.28 nM
N=C1N[C@H](O)C2C3OC4(O)O[C@@H]([C@@H](O)C2(N1)[C@@H]4O)[C@]3(O)CO CHEMBL4753470 EC50 1.9 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC23CCCN2CCC3)cc1F CHEMBL4061793 IC50 2.2 nM
CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(Cc3cc(C(F)(F)F)ccc3Cl)CC2)cc1F CHEMBL4444707 IC50 3.2 nM
Nc1[nH]ncc1-c1cc(Cl)ccc1Oc1cc(F)c(S(=O)(=O)Nc2cscn2)cc1Cl CHEMBL2325014 IC50 11.0 nM
O=C(NS(=O)(=O)N1CCOCC1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F CHEMBL3657939 IC50 14.0 nM
O=S(=O)(Nc1cccc(F)n1)c1cc(F)c(O[C@H]2CCN(CC(F)(F)F)C[C@@H]2c2ccc(F)c(F)c2)c(F)c1 CHEMBL4854735 IC50 15.8 nM
O=C(Nc1cccc(C(F)(F)F)c1-c1ccccn1)c1cccc(-c2ncccc2OC(F)F)c1 CHEMBL4079509 IC50 18.0 nM
Fc1ccccc1Cn1ccc2c(OC3CCN(Cc4cscn4)CC3)ncnc21 CHEMBL2012259 IC50 20.0 nM
Fc1cccc(Cn2ccc3c(OC4CCN(Cc5ccccn5)CC4)ncnc32)c1F CHEMBL2012299 IC50 20.0 nM
O=C(NS(=O)(=O)NCCCO)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F CHEMBL3657952 IC50 22.0 nM
O=C(NS(=O)(=O)C1CC1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F CHEMBL3657932 IC50 26.0 nM
CC[C@H](C)[C@@H]1NC(=O)[C@@H](NC(=O)CN)CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N4C[C@@H](O)C[C@H]4C(=O)N4C[C@@H](O)C[C@H]4C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N3)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC2=O CHEMBL5077579 EC50 27.8 nM
Fc1cn(Cc2ccccc2)c2ncnc(OC3CCN(Cc4cscn4)CC3)c12 CHEMBL2012180 IC50 30.0 nM
Fc1ccccc1Cn1ccc2c(OC3CCN(Cc4ccccn4)CC3)ncnc21 CHEMBL2012298 IC50 30.0 nM
Cn1nccc1-c1cc(C(F)(F)F)ccc1-c1cccc2cc(S(=O)(=O)Nc3ncns3)ccc12 CHEMBL3677849 IC50 30.0 nM
O=S(=O)(Nc1cccc(F)n1)c1cc(F)c(O[C@H]2CCN(CC(F)(F)F)C[C@@H]2c2ccc(F)c(F)c2)c(F)c1F CHEMBL4864812 IC50 31.0 nM
O=S1(=O)CCC(CCNc2cc(F)c(S(=O)(=O)Nc3nccs3)cc2Cl)CC1 CHEMBL4075332 IC50 37.0 nM
Fc1c(Cn2ccc3c(OC4CCN(Cc5cscn5)CC4)ncnc32)cccc1C(F)(F)F CHEMBL2012273 IC50 40.0 nM
Fc1cccc(F)c1Cn1ccc2c(OC3CCN(Cc4cscn4)CC3)ncnc21 CHEMBL2012274 IC50 40.0 nM
Cc1ccnc(CN2CCC(Oc3ncnc4c3ccn4Cc3ccccc3)CC2)c1 CHEMBL2012292 IC50 40.0 nM
O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC2CCCCC2)cc1F CHEMBL3662238 IC50 40.0 nM
O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F CHEMBL3657855 IC50 49.0 nM
Cc1cn(Cc2ccccc2)c2ncnc(OC3CCN(Cc4cscn4)CC3)c12 CHEMBL2012179 IC50 50.0 nM
Fc1c(Cl)cccc1Cn1ccc2c(OC3CCN(Cc4cscn4)CC3)ncnc21 CHEMBL2012272 IC50 50.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCCC2CCCOC2)cc1F CHEMBL4094490 IC50 50.0 nM
CC1(COc2cc(F)c(C(=O)NS(=O)(=O)C3CC3)cc2C2CC2)CCC2(CC1)CC2 CHEMBL3662190 IC50 50.0 nM
O=C1CCCC(CNc2cc(F)c(S(=O)(=O)Nc3nccs3)cc2Cl)C1 CHEMBL4102624 IC50 52.0 nM
C[Si](C)(C)c1ccc(-c2ccc3nnc(C(F)(F)F)n3c2)cc1 CHEMBL3810248 IC50 59.0 nM
Cc1cccc(Cn2ccc3c(OC4CCN(Cc5cscn5)CC4)ncnc32)c1 CHEMBL2012266 IC50 60.0 nM
Cc1ccc(CN2CCC(Oc3ncnc4c3ccn4Cc3ccccc3)CC2)nc1 CHEMBL2012291 IC50 60.0 nM
O=C(NS(=O)(=O)N1CC(O)C1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F CHEMBL3657838 IC50 60.6 nM
Fc1cccc(Cn2ccc3c(OC4CCN(Cc5cscn5)CC4)ncnc32)c1F CHEMBL2012271 IC50 70.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC2COCCO2)cc1F CHEMBL4087220 IC50 74.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC[C@H]2CCCOC2)cc1F CHEMBL4072883 IC50 76.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC[C@H]2CCCO[C@@H]2c2ccccc2)cc1F CHEMBL4102233 IC50 77.0 nM
CSCC[C@@H]1NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](N)Cc3ccc(O)cc3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]3CSSC[C@H](NC(=O)[C@H](C(C)C)NC1=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(=O)O)CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC3=O)C(=O)N2 CHEMBL4224739 IC50 79.0 nM
Clc1cn(Cc2ccccc2)c2ncnc(OC3CCN(Cc4cscn4)CC3)c12 CHEMBL2012181 IC50 80.0 nM
Cc1nc(CN2CCC(Oc3ncnc4c3ccn4Cc3ccccc3)CC2)cs1 CHEMBL2012285 IC50 80.0 nM
Fc1c(Cl)cccc1Cn1ccc2c(OC3CCN(Cc4ccccn4)CC3)ncnc21 CHEMBL2012300 IC50 80.0 nM
O=C1N(Cc2ccc(C(F)(F)F)o2)c2ccccc2[C@]12COc1cc3c(cc12)OCO3 CHEMBL3707218 IC50 84.0 nM
Cc1cccc(CN2CCC(Oc3ncnc4c3ccn4Cc3ccccc3)CC2)n1 CHEMBL2012290 IC50 90.0 nM
Fc1cccnc1CN1CCC(Oc2ncnc3c2ccn3Cc2ccccc2)CC1 CHEMBL2012296 IC50 90.0 nM
CSCC[C@@H]1NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](N)Cc3ccc(O)cc3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]3CSSC[C@H](NC(=O)[C@H](C(C)C)NC1=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(=O)O)CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC3=O)C(=O)N2 CHEMBL3318132 IC50 90.0 nM
O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC2(C(F)(F)F)CCCC2)cc1F CHEMBL3662081 IC50 90.0 nM
CON=C1CCC(CNc2cc(F)c(S(=O)(=O)Nc3nccs3)cc2Cl)CC1 CHEMBL4100176 IC50 94.0 nM
CC(C)(C)c1ccc(-c2ccc(C(=O)N3CCN(C4CCCCC4)CC3)o2)cc1 CHEMBL486495 IC50 100.0 nM
O=C1c2cc(-c3ccc(OC(F)(F)F)cc3)ccc2OCCN1Cc1ncccn1 CHEMBL3707392 IC50 100.0 nM
COCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F CHEMBL3657840 IC50 101.0 nM
FC(F)(F)Oc1ccc(-c2ccc3cnc(C(F)(F)F)n3c2)cc1 CHEMBL3809404 IC50 102.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC[C@]23CCO[C@H]2OCC3)cc1F CHEMBL4104727 IC50 108.0 nM
CC[C@H](C)[C@@H]1NC(=O)[C@@H](NC(=O)CN)CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N4C[C@@H](O)C[C@H]4C(=O)N4C[C@@H](O)C[C@H]4C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N3)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC2=O CHEMBL5091623 EC50 108.4 nM
Clc1ccccc1Cn1ccc2c(OC3CCN(Cc4cscn4)CC3)ncnc21 CHEMBL2012262 IC50 110.0 nM
Fc1ccc(CN2CCC(Oc3ncnc4c3ccn4Cc3ccccc3)CC2)nc1 CHEMBL2012295 IC50 110.0 nM
O=C(NS(=O)(=O)N1CC[C@H](O)C1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F CHEMBL3657931 IC50 110.0 nM
O=S(=O)(Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(C3CC3)cn12)C1CC1 CHEMBL4290579 IC50 110.0 nM
COc1ccc2c(c1)NC1(CCN(C(=O)c3ccc(OC)c(N4CCCC4)c3)CC1)c1cccn1-2 CHEMBL3337595 IC50 118.0 nM
Cc1c(C)n(Cc2ccccc2)c2ncnc(OC3CCN(Cc4cscn4)CC3)c12 CHEMBL2012178 IC50 120.0 nM
FC(F)(F)c1ccccc1Cn1ccc2c(OC3CCN(Cc4cscn4)CC3)ncnc21 CHEMBL2012268 IC50 120.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCCC2CCOCC2)cc1F CHEMBL4064762 IC50 120.0 nM
Cc1cc(OC(F)(F)F)ccc1-c1ccc2nnc(C(F)(F)F)n2c1 CHEMBL3809360 IC50 123.0 nM
O=S(=O)(Nc1nccs1)c1ccc2c(c1)OCC[C@@H]2c1ccc(C(F)(F)F)cc1-c1ccc(F)cc1 CHEMBL4636838 IC50 124.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC2CCOCC2)cc1F CHEMBL4102647 IC50 127.0 nM
CC1(C)C(=O)N(Cc2ccccc2)c2ncnc(OC3CCN(Cc4cscn4)CC3)c21 CHEMBL2012250 IC50 130.0 nM
O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC2C3CC4CC(C3)CC2C4)cc1F CHEMBL3657972 IC50 130.0 nM
O=C(NS(=O)(=O)C1CC1)c1cc(C2CC2)c(OCC23CC4CC(C2)C(F)(F)C(C4)C3)cc1F CHEMBL3662090 IC50 130.0 nM
CC[C@H](C)[C@@H]1NC(=O)[C@@H](NC(=O)CN)CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N4C[C@@H](O)C[C@H]4C(=O)N4C[C@@H](O)C[C@H]4C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N3)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC2=O CHEMBL5093878 EC50 132.7 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCCCC2CCOC2)cc1F CHEMBL4073353 IC50 133.0 nM
CC[C@H](C)[C@@H]1NC(=O)[C@@H](NC(=O)CN)CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N4C[C@@H](O)C[C@H]4C(=O)N4C[C@@H](O)C[C@H]4C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N3)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC2=O CHEMBL5091679 EC50 138.3 nM
Cc1ccccc1Cn1ccc2c(OC3CCN(Cc4cscn4)CC3)ncnc21 CHEMBL2012265 IC50 140.0 nM
COCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCCCC2)cc1F CHEMBL3657967 IC50 140.0 nM
COc1cc(-c2cccc(F)c2)c(Cl)cc1-c1c(N)nnc2cc(S(=O)(=O)Nc3ccon3)ccc12 CHEMBL4090259 IC50 140.0 nM
O=C(NCc1ccccc1)[C@@H](c1ccccc1)N1CCN(Cc2ccccc2)CC1 CHEMBL4288200 IC50 140.0 nM
COC1CN(S(=O)(=O)NC(=O)c2cc(C3CC3)c(OCC34CC5CC(CC(C5)C3)C4)cc2F)C1 CHEMBL3657953 IC50 144.0 nM
CC[C@H](C)[C@@H]1NC(=O)[C@@H](NC(=O)CN)CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N4C[C@@H](O)C[C@H]4C(=O)N4C[C@@H](O)C[C@H]4C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N3)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC2=O CHEMBL5083412 EC50 149.2 nM
Cc1cccnc1CN1CCC(Oc2ncnc3c2ccn3Cc2ccccc2)CC1 CHEMBL2012293 IC50 150.0 nM
O=C1CCC(CNc2cc(F)c(S(=O)(=O)Nc3nccs3)cc2Cl)CC1 CHEMBL4073324 IC50 150.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC[C@H]2CCC[C@@H](O)C2)cc1F CHEMBL4094879 IC50 151.0 nM
O=S(=O)(Nc1nccs1)c1ccc2c(c1)OCC[C@@H]2c1ccc(C(F)(F)F)cc1-c1ccc(F)nc1 CHEMBL4634421 IC50 154.0 nM
CC[C@H](C)[C@@H]1NC(=O)[C@@H](NC(=O)CN)CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](CCCCN)C(=O)N4C[C@@H](O)C[C@H]4C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)[C@@H]4CCCN4C1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N3)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC2=O CHEMBL5084333 EC50 155.6 nM
CC(C)(C)[C@H]1OCCC[C@@H]1CNc1cc(F)c(S(=O)(=O)Nc2nccs2)cc1Cl CHEMBL4064295 IC50 156.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC[C@H]2CC[C@H](O)CC2)cc1F CHEMBL4092435 IC50 156.0 nM
CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F CHEMBL3657851 IC50 159.0 nM
c1ccc(Cn2ccc3c(OC4CCN(Cc5ccccn5)CC4)ncnc32)cc1 CHEMBL2012287 IC50 160.0 nM
O=C(NS(=O)(=O)C1CC1)c1cc(C2CC2)c(OCC2(C(F)(F)F)CCCCC2)cc1F CHEMBL3662229 IC50 160.0 nM
O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC23CCCCC2C3)cc1F CHEMBL3662093 IC50 160.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC2CCCC3(C2)OCCO3)cc1F CHEMBL4074392 IC50 162.0 nM
Cc1cc(-c2ccc3nnc(C(F)(F)F)n3c2)ccc1OC(F)(F)F CHEMBL3810234 IC50 166.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC[C@]23CCC[C@@]2(O)CCC3)cc1F CHEMBL4071736 IC50 169.0 nM
CSCC[C@@H]1NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](N)Cc3ccc(O)cc3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H]3CSSC[C@H](NC(=O)[C@H](C(C)C)NC1=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(N)=O)CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC3=O)C(=O)N2 CHEMBL3318147 IC50 180.0 nM
COc1ccc(C(=O)N2CCC3(CC2)Nc2cc(OC(F)(F)F)ccc2-n2cccc23)cc1N(C)C CHEMBL3337583 IC50 181.0 nM
CC(C)(C)c1ccc(-c2ccc3nnc(C(F)(F)F)n3c2)cc1 CHEMBL3808867 IC50 182.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC2CCOC2)cc1F CHEMBL4101414 IC50 188.0 nM
O=S(=O)(Nc1cccc(F)n1)c1ccc2c(c1)OCC[C@@H]2c1ccc(C(F)(F)F)cc1N1CCOCC1 CHEMBL4641925 IC50 188.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC2CCCO2)cc1F CHEMBL4100208 IC50 189.0 nM
FC(F)(F)c1cccc(Cn2ccc3c(OC4CCN(Cc5cscn5)CC4)ncnc32)c1 CHEMBL2012269 IC50 190.0 nM
Fc1c(Cn2ccc3c(OC4CCN(Cc5ccccn5)CC4)ncnc32)cccc1C(F)(F)F CHEMBL2012301 IC50 190.0 nM
Cn1c(SCc2ccc(C(C)(C)C)cc2)nc(N)cc1=O CHEMBL1938867 IC50 200.0 nM
Nc1ncnc(Nc2ccc(Oc3ccc(Cl)cc3)cc2)n1 CHEMBL2011947 IC50 200.0 nM
c1ccc(Cn2ccc3c(OC4CCN(Cc5cscn5)CC4)ncnc32)cc1 CHEMBL2012244 IC50 200.0 nM
CCCCNc1ccc(C(=O)OCCN(C)C)cc1 CHEMBL698 IC50 200.0 nM
N#Cc1cc(C(F)(F)F)ccc1N1CCOc2cc(S(=O)(=O)Nc3nccs3)c(F)cc21 CHEMBL3950353 IC50 203.0 nM
N=C1N[C@H]2[C@H](COC(N)=O)NC(=N)N3CCC(O)(O)[C@]23N1 CHEMBL501134 IC50 210.0 nM
FC(F)(F)c1ccc(-c2ccc3nnc(C(F)(F)F)n3c2)cc1 CHEMBL3808645 IC50 211.0 nM
O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCCN2c1ccc(C(F)(F)F)cc1C1=CCOCC1 CHEMBL3928707 IC50 214.0 nM
CC[C@H](C)[C@@H]1NC(=O)[C@@H](NC(=O)CN)CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N4C[C@@H](O)C[C@H]4C(=O)N4C[C@@H](O)C[C@H]4C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N3)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC2=O CHEMBL5082582 EC50 215.2 nM
COc1ccc(C(=O)N2CCC3(CC2)Nc2cc(C(F)(F)F)ccc2-n2cccc23)cc1N(C)C CHEMBL3337585 IC50 217.0 nM
O=C(Nc1cccc(C(F)(F)F)c1-c1cccnc1)c1cccc(-c2ncccc2OC(F)F)c1 CHEMBL4100413 IC50 220.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCCC2CCOC2)cc1F CHEMBL4076229 IC50 221.0 nM
FC(F)(F)Oc1ccc(-c2ccc3nnc(C(F)(F)F)n3n2)cc1 CHEMBL3810347 IC50 223.0 nM
CNc1noc2ccc(-c3cc(Cl)ccc3Oc3cc(F)c(S(=O)(=O)Nc4ncns4)cc3F)cc12 CHEMBL3806065 IC50 230.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC2CCCCO2)cc1F CHEMBL4092463 IC50 237.0 nM
CN(C)C(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 CHEMBL841 IC50 239.0 nM
Nc1ccnc(Nc2ccc(Oc3ccc(OC(F)(F)F)cc3)cc2)n1 CHEMBL2012038 IC50 240.0 nM
O=S(=O)(Nc1cccc(F)n1)c1cc(F)c(OC2CCN(CC(F)(F)F)CC2c2ccc(F)c(F)c2)cc1F CHEMBL4849813 IC50 240.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC2OCCO2)cc1F CHEMBL4083744 IC50 242.0 nM
O=S(=O)(Nc1ccncn1)c1ccc2c(c1)OCC[C@@H]2c1ccc(C(F)(F)F)cc1N1CCOCC1 CHEMBL4647267 IC50 248.0 nM
CC1(C)CN(Cc2ccccc2)c2ncnc(OC3CCN(Cc4cscn4)CC3)c21 CHEMBL2012249 IC50 250.0 nM
FC(F)(F)Oc1ccc(-c2ccc3nnc(C(F)(F)F)n3c2)cc1 CHEMBL3809595 IC50 250.0 nM
O=S(=O)(Nc1nccs1)c1ccc2c(c1)OCCN2c1ccc(C(F)(F)F)cc1C1=CCNCC1 CHEMBL3929582 IC50 254.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC23CC4CC(CC(O)(C4)C2)C3)cc1F CHEMBL4061129 IC50 260.0 nM
C#CC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(N)=O)[C@@H](C)CC)NC(=O)[C@H](Cc4c[nH]c5ccc(Br)cc45)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCC)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N3)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC2=O CHEMBL4169884 IC50 260.0 nM
O=S(=O)(Nc1cccc(F)n1)c1cc(F)c(O[C@H]2CCN(CC(F)(F)F)C[C@@H]2c2ccc(F)c(F)c2)cc1F CHEMBL4863095 IC50 260.0 nM
CC1(COc2cc(F)c(C(=O)NS(=O)(=O)C3CC3)cc2C2CC2)CCC(F)(F)CC1 CHEMBL3662077 IC50 260.0 nM
CS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(C3CC3)cn12 CHEMBL4279238 IC50 265.0 nM
O=S1(=O)CCC(CNc2cc(F)c(S(=O)(=O)Nc3nccs3)cc2Cl)C1 CHEMBL4082252 IC50 266.0 nM
FC(F)(F)COc1ccc(-c2ccc3nnc(C(F)(F)F)n3c2)cc1 CHEMBL3809838 IC50 281.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC[C@H]2CCC[C@H](O)C2)cc1F CHEMBL4084685 IC50 281.0 nM
CC(=O)Nc1cccc(Nc2ncnc(N3CCC(Oc4ccc(OC(F)(F)F)cc4)CC3)n2)c1C CHEMBL1813050 IC50 300.0 nM
CC(C)(C)c1ccc(CSc2nc(N)cc(O)n2)cc1 CHEMBL1313991 IC50 300.0 nM
Clc1cccc(Cn2ccc3c(OC4CCN(Cc5cscn5)CC4)ncnc32)c1 CHEMBL2012263 IC50 300.0 nM
O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCCN2c1ccc(C(F)(F)F)cc1-c1ccncc1 CHEMBL3952945 IC50 306.0 nM
O=C(NS(=O)(=O)N1CC(F)(F)C1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F CHEMBL3657943 IC50 326.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC[C@@H]2CCCOC2)cc1F CHEMBL4092025 IC50 328.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC2CCOCC2)cc1F CHEMBL4062009 IC50 336.0 nM
COc1ccc(C(=O)N2CCC3(CC2)Nc2cc(OC(F)F)ccc2-n2cccc23)cc1N(C)C CHEMBL3337584 IC50 340.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCCC2CCC3(CC2)OCCO3)cc1F CHEMBL4098747 IC50 348.0 nM
O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCCN2c1ccc(C(F)(F)F)cc1C1=CCNCC1 CHEMBL3922400 IC50 349.0 nM
Cc1nc(OC2CCN(Cc3cscn3)CC2)c2ccn(Cc3ccccc3)c2n1 CHEMBL2012245 IC50 350.0 nM
O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC2(C(F)(F)F)CCCCC2)cc1F CHEMBL3658002 IC50 350.0 nM
COc1ccc2c(c1)NC1(CCN(C(=O)c3ccc(OC)c(N(C)C)c3)CC1)c1cccn1-2 CHEMBL3322777 IC50 351.0 nM
FC(F)c1nnc2ccc(-c3ccc(OC(F)(F)F)cc3)cn12 CHEMBL3809528 IC50 351.0 nM
FC(F)(F)Oc1ccc(-c2ccc3ncc(C(F)(F)F)n3c2)cc1 CHEMBL3809853 IC50 353.0 nM
COc1cc2c(cc1F)-n1cccc1C1(CCN(C(=O)c3ccc(OC)c(N(C)C)c3)CC1)N2 CHEMBL3337587 IC50 358.0 nM
Nc1ccnc(Nc2ccc(Oc3ccccc3Cl)cc2)n1 CHEMBL2012027 IC50 360.0 nM
O=S(=O)(Nc1nccs1)c1ccc2c(c1)OCC[C@@H]2c1ccc(C(F)(F)F)cc1-c1ccc(F)cn1 CHEMBL4641467 IC50 362.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC[C@H]2CC[C@@H](O)CC2)cc1F CHEMBL4068484 IC50 380.0 nM
N#Cc1cc(C(F)(F)F)ccc1N1CCOc2cc(S(=O)(=O)Nc3nccs3)cc(F)c21 CHEMBL3948638 IC50 385.0 nM
FC(F)(F)c1nnc2ccc(-c3ccc(S(F)(F)(F)(F)F)cc3)cn12 CHEMBL3809777 IC50 397.0 nM
CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](Cc4cccc5ccccc45)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N2)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C(N)=O)C(C)C)NC(=O)[C@H](Cc2c[nH]c4ccccc24)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC3=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]2CCCN2C1=O CHEMBL3416937 IC50 400.0 nM
O=C(Nc1cccc(C(F)(F)F)c1N1CCOCC1)c1cccc(-c2ccccn2)c1 CHEMBL4076874 IC50 400.0 nM
N#Cc1cc(OC(F)(F)F)cc(C(=O)N2CCN([C@@H](C(=O)NCc3ccccc3)c3ccccc3)CC2)c1 CHEMBL4284381 IC50 400.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC2CCC3(CC2)OCCO3)cc1F CHEMBL4095822 IC50 407.0 nM
Cc1ccc(Oc2ccc(Nc3cncc(N)n3)cc2)cc1 CHEMBL2012041 IC50 410.0 nM
O=S(=O)(Nc1cccc(F)n1)c1cc(F)c(O[C@H]2CCN(CC(F)(F)F)C[C@@H]2c2ccccc2)cc1F CHEMBL4859414 IC50 410.0 nM
CC(C)(C)[C@@H]1OCCC[C@@H]1CNc1cc(F)c(S(=O)(=O)Nc2nccs2)cc1Cl CHEMBL4084268 IC50 415.0 nM
FC(F)(F)Oc1ccc(-c2ccn3ncc(C(F)(F)F)c3c2)cc1 CHEMBL3809904 IC50 417.0 nM
COc1ccc2c(c1)NC1(CCN(C(=O)c3ccc4ccccc4n3)CC1)c1cccn1-2 CHEMBL3337599 IC50 419.0 nM
O=C(NS(=O)(=O)N1CC(F)C1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F CHEMBL3657934 IC50 422.0 nM
FC(F)(F)Oc1ccc(-c2ccn3nccc3c2)cc1 CHEMBL3809080 IC50 425.0 nM
O=C(NS(=O)(=O)C1CC1)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)cc1F CHEMBL3657930 IC50 427.0 nM
O=C(NS(=O)(=O)C1CC1)c1cc(C2CC2)c(OCC23CC4(F)CC(F)(CC(F)(C4)C2)C3)cc1F CHEMBL3658014 IC50 430.0 nM
O=C(Nc1cccc(C(F)(F)F)c1-c1ncccc1Cl)c1cccc(-c2ncccc2C(F)(F)F)c1 CHEMBL4077551 IC50 430.0 nM
Cc1nn([C@@H]2CCN([C@H](C)c3cc(Cl)cc(Cl)c3)C2)c2cc(F)c(C(=O)NS(=O)(=O)C3CC3)cc12 CHEMBL4471012 IC50 435.0 nM
Cn1cc(CN2CCC(Oc3ncnc4c3ccn4Cc3ccccc3)CC2)cn1 CHEMBL2012283 IC50 440.0 nM
COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1 CHEMBL517427 AC50 440.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC2CCC(=NOCc3ccccc3)CC2)cc1F CHEMBL4064737 IC50 444.0 nM
COc1ccc2c(c1)NC1(CCN(Cc3ccccc3)CC1)c1cccn1-2 CHEMBL3322762 IC50 455.0 nM
Nc1cncc(Nc2ccc(Oc3ccc(C(F)(F)F)cc3)cc2)n1 CHEMBL2012044 IC50 460.0 nM
Cc1cn(C2C=CCCC2)c2ccc(C(=O)NS(=O)(=O)C3CC3)cc12 CHEMBL4464346 IC50 460.0 nM
O=S(=O)(Nc1cccc(F)n1)c1cc(F)c(O[C@H]2CCN(CC(F)(F)F)C[C@@H]2c2cccc(F)c2)cc1F CHEMBL4853170 IC50 460.0 nM
Nc1cncc(Nc2ccc(Oc3ccc(F)cc3)cc2)n1 CHEMBL2012040 IC50 470.0 nM
O=S(=O)(Nc1cccc(F)n1)c1cc(F)c(O[C@H]2CCN(CC(F)(F)F)C[C@@H]2c2ccc(F)cc2F)cc1F CHEMBL4860097 IC50 470.0 nM
O=S(=O)(Nc1nccs1)c1ccc2c(c1)OCCN2c1ccc(C(F)(F)F)cc1CCO CHEMBL3946486 IC50 471.0 nM
O=C(Nc1cccc(C(F)(F)F)c1-c1ccccn1)c1cccc(-c2ncccc2C(F)(F)F)c1 CHEMBL4063274 IC50 480.0 nM
CNC(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 CHEMBL1627 IC50 483.0 nM
O=S(=O)(Nc1ncns1)c1ccc2c(-c3ccc(C(F)(F)F)cc3O)cccc2c1 CHEMBL3682649 IC50 490.0 nM
COc1cc(-c2ccc(F)c(C)c2)c(F)cc1-n1c(=O)ccc2cc(S(=O)(=O)Nc3ccon3)c(F)cc21 CHEMBL3979043 IC50 496.0 nM
O=S(=O)(Nc1nccs1)c1ccc2c(c1)OCCN2c1ccc(C(F)(F)F)cc1C[C@@H](O)CO CHEMBL4109740 IC50 497.0 nM
CC(=O)Nc1cccc(Nc2ncnc(N3CCC(Oc4ccc(C(F)(F)F)cc4)CC3)n2)c1C CHEMBL1813049 IC50 500.0 nM
Nc1ccnc(Nc2ccc(Oc3ccc(Cl)cc3)cc2)n1 CHEMBL2011950 IC50 500.0 nM
CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N2)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C(N)=O)C(C)C)NC(=O)[C@H](Cc2c[nH]c4ccccc24)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC3=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]2CCCN2C1=O CHEMBL3416944 IC50 500.0 nM
COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C CHEMBL45816 IC50 500.0 nM
COc1cc([C@H](C(=O)NCc2ccccc2)N2CCN(C(=O)c3cc(F)cc(F)c3)CC2)ccc1C#N CHEMBL4287784 IC50 500.0 nM
COc1ccc2c(c1)N[C@@]1(CCN(C(=O)c3ccc(OC)c(N(C)C)c3)C[C@@H]1C)c1cccn1-2 CHEMBL3337589 IC50 519.0 nM
O=C(Nc1cccc(C(F)(F)F)c1-c1cccnc1)c1cccc(-c2ncccc2Cl)c1 CHEMBL4076051 IC50 520.0 nM
Fc1cccc(CN2CCC(Oc3ncnc4c3ccn4Cc3ccccc3)CC2)n1 CHEMBL2012294 IC50 550.0 nM
C[C@@H](c1cc(Cl)cc(Cl)c1)N1CCC(COc2cc(F)c(C(=O)NS(C)(=O)=O)cc2C2CC2)CC1 CHEMBL5094715 IC50 551.0 nM
O=S(=O)(Nc1nccs1)c1ccc2c(c1)OCCN2c1ccc(C(F)(F)F)cc1-c1ccncc1 CHEMBL3909534 IC50 554.0 nM
CCCCOc1ccc(C(=O)NC(=N)NCCCCc2ccccc2)cc1 CHEMBL108347 IC50 560.0 nM
COc1ccc2c(c1)NC1(CCN(C(=O)c3ccc(N(C)C)c(Cl)c3)CC1)c1cccn1-2 CHEMBL3322775 IC50 572.0 nM
c1ccc(Cn2ccc3c(OC4CCN(Cc5ccn[nH]5)CC4)ncnc32)cc1 CHEMBL2012281 IC50 580.0 nM
O=S(=O)(Nc1ncns1)c1cc(F)c(OC2OCCNC2c2cccc(C(F)(F)F)c2)cc1F CHEMBL4209664 IC50 580.0 nM
Cc1ccc(Oc2ccc(Nc3nccc(N)n3)cc2)cc1 CHEMBL2012029 IC50 590.0 nM
CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(C(c3ccccc3)c3ccccc3)CC2)cc1F CHEMBL5091342 IC50 590.0 nM
N#Cc1cc(C(F)(F)F)ccc1N1CCOc2cc(S(=O)(=O)Nc3nccs3)c(Cl)cc21 CHEMBL3907025 IC50 610.0 nM
O=S(=O)(Nc1cccc(F)n1)c1cc(F)c(O[C@H]2CCN(CC(F)(F)F)C[C@@H]2c2ccc(F)cc2)cc1F CHEMBL4865860 IC50 610.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC[C@@]23CCCO[C@@H]2OCC3)cc1F CHEMBL4071860 IC50 614.0 nM
Cc1nc(-c2cc(C(F)(F)F)ccc2[C@H]2CCOc3cc(S(=O)(=O)Nc4nccs4)ccc32)co1 CHEMBL4639228 IC50 629.0 nM
O=C(NS(=O)(=O)C1CC1)c1cc(C2CC2)c(OCC2CCC(F)(F)CC2)cc1F CHEMBL3657998 IC50 630.0 nM
Nc1cc(-c2cc(C(F)(F)F)ccc2N2CCOc3cc(S(=O)(=O)Nc4ncns4)ccc32)ccn1 CHEMBL3959065 IC50 634.0 nM
O=S(=O)(Nc1nccs1)c1ccc2c(c1)OCCN2c1ccc(C(F)(F)F)cc1C(O)CO CHEMBL3932071 IC50 637.0 nM
CC1(C)CCc2cc(OCc3cc(F)c(C(=O)NS(=O)(=O)N4CCC4)cc3Cl)ccc2O1 CHEMBL3657848 IC50 653.0 nM
Cc1ncccc1-c1c(NC(=O)c2cccc(-c3ncccc3C(F)(F)F)c2)cccc1C(F)(F)F CHEMBL4085326 IC50 660.0 nM
CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCCCC2)cc1F CHEMBL3662236 IC50 670.0 nM
O=S(=O)(Nc1cccc(F)n1)c1cc(F)c(O[C@H]2CCN(CC(F)(F)F)C[C@@H]2c2ccccc2F)cc1F CHEMBL4876448 IC50 680.0 nM
CC(C)c1ccc(N2CCOc3cc(S(=O)(=O)Nc4nccs4)ccc32)c(C#N)c1 CHEMBL3941069 IC50 686.0 nM
CS(=O)(=O)NC(=O)c1ccc(OCC23CC4CC(CC(C4)C2)C3)c(C2CC2)c1 CHEMBL3657877 IC50 700.0 nM
CC1CC(CNc2cc(F)c(S(=O)(=O)Nc3nccs3)cc2Cl)CC(C)O1 CHEMBL4084713 IC50 706.0 nM
O=C(NCC1CC1)[C@@H](c1ccccc1)N1CCN(C(=O)c2cc(F)cc(F)c2)CC1 CHEMBL4283471 IC50 710.0 nM
CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(C2)C(F)(F)C(C4)C3)cc1F CHEMBL3657937 IC50 714.0 nM
Nc1cncc(Nc2ccc(Oc3ccc(Cl)cc3)cc2)n1 CHEMBL2012017 IC50 720.0 nM
C[C@H]1CN(c2ccc(C(F)(F)F)cc2C#N)c2ccc(S(=O)(=O)Nc3nccs3)cc2O1 CHEMBL3904727 IC50 724.0 nM
O=C(NCc1ccc(OC(F)(F)F)cc1)C1c2ccccc2C(=O)N1CCc1ccccn1 CHEMBL2164389 IC50 730.0 nM
O=S(=O)(Nc1nccs1)c1ccc2c(c1)OCCN2c1ccc(C(F)(F)F)cc1-c1cncnc1 CHEMBL3948444 IC50 731.0 nM
c1ccc(CN2CCC(Oc3ncnc4c3ccn4Cc3ccccc3)CC2)cc1 CHEMBL2012277 IC50 740.0 nM
CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CC3C4CCC(C4)C3C2)cc1F CHEMBL3657929 IC50 743.0 nM
O=S(=O)(Nc1cscn1)c1cc(F)c(O[C@H]2CCN(CC(F)(F)F)C[C@@H]2c2ccc(F)c(F)c2)cc1F CHEMBL4872374 IC50 750.0 nM
O=C(NS(=O)(=O)C1COC1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F CHEMBL5082739 IC50 750.0 nM
CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)cc1F CHEMBL3657820 IC50 772.0 nM
Nc1ccnc(Nc2ccc(Oc3ccc(F)cc3)cc2)n1 CHEMBL2012028 IC50 780.0 nM
COc1ncc(-c2c(C)ccc(F)c2CCNC(=O)c2ccc(OCCC(F)(F)F)nc2)cn1 CHEMBL2147305 pIC50 794.33 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC2CCCOC2)cc1F CHEMBL4099769 IC50 796.0 nM
CSCC[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@H](C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](Cc4ccccc4)NC1=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N3)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCCN)NC2=O CHEMBL4588728 IC50 800.0 nM
O=C(NCc1ccc(OC(F)(F)F)cc1)C1c2c(F)cccc2C(=O)N1CCc1ccccn1 CHEMBL2164368 IC50 810.0 nM
Cn1nccc1-c1cc(C(F)(F)F)ccc1[C@H]1CCOc2cc(S(=O)(=O)Nc3nccs3)ccc21 CHEMBL4646742 IC50 812.0 nM
COc1cc(-c2cccc(F)c2)c(Cl)cc1-c1[nH]c(=O)cc2cc(S(=O)(=O)Nc3ccon3)ccc12 CHEMBL4068143 IC50 820.0 nM
O=C(Nc1cccc(C(F)(F)F)c1-c1cccnc1)c1cccc(-c2ncccc2C(F)(F)F)c1 CHEMBL4076380 IC50 820.0 nM
C[C@@H]1COc2cc(S(=O)(=O)Nc3nccs3)ccc2N1c1ccc(C(F)(F)F)cc1C#N CHEMBL4115193 IC50 851.0 nM
N#Cc1cc(-c2cccc(F)c2)ccc1N1CCOc2cc(S(=O)(=O)Nc3nccs3)ccc21 CHEMBL3917677 IC50 854.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCCC2CCCCO2)cc1F CHEMBL4065798 IC50 874.0 nM
FC(F)Oc1ccc(-c2ccc3nnc(C(F)(F)F)n3c2)cc1 CHEMBL3808917 IC50 887.0 nM
O=S(=O)(Nc1nccs1)c1ccc2c(c1)OCCN2c1ccc(C(F)(F)F)cc1C[C@H](O)CO CHEMBL3894090 IC50 896.0 nM
CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N2)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C(N)=O)C(C)C)NC(=O)[C@H](Cc2c[nH]c4ccccc24)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2cccc4ccccc24)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC3=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]2CCCN2C1=O CHEMBL3800504 IC50 900.0 nM
FC(F)(F)Oc1ccc(-c2ccn3ncc(C(F)(F)F)c3n2)cc1 CHEMBL3810153 IC50 901.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC23CC4CC(C2)C(O)C(C4)C3)cc1F CHEMBL4089301 IC50 916.0 nM
O=C(NCc1noc(-c2c3ccccc3nn2CCn2ccnc2)n1)c1cccc(OC(F)(F)F)c1 CHEMBL3236329 IC50 920.0 nM
c1ccc(Cn2ncc3c(OC4CCN(Cc5cscn5)CC4)ncnc32)cc1 CHEMBL2012247 IC50 930.0 nM
O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC2CC3CCC2O3)cc1F CHEMBL4069801 IC50 931.0 nM
COc1ccc2c(c1)NC1(CCN(C(=O)c3ccc(OC)c(Cl)c3)CC1)c1cccn1-2 CHEMBL3322776 IC50 934.0 nM
O=C(NCc1ccc(OC(F)(F)F)cc1)C1c2cccc(O)c2C(=O)N1CCc1ccccn1 CHEMBL2164041 IC50 940.0 nM
O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC2CCC(F)(F)CC2)cc1F CHEMBL3662230 IC50 940.0 nM
FC(F)(F)Oc1ccc(-c2ccc3ncnn3c2)cc1 CHEMBL3809877 IC50 941.0 nM
O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCCN2c1ccc(C(F)(F)F)cc1-c1cn[nH]c1 CHEMBL3902709 IC50 944.0 nM
COc1ccc2c(c1)NC1(CCN(C(=O)c3ccc(N(C)C)cc3)CC1)c1cccn1-2 CHEMBL3322773 IC50 947.0 nM
O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC23CC4(F)CC(F)(CC(F)(C4)C2)C3)cc1F CHEMBL3658000 IC50 950.0 nM
O=C(NCc1ccccc1)[C@@H](c1ccccc1)N1CCN(C(=O)c2cc(F)ccc2Cl)CC1 CHEMBL4277551 IC50 950.0 nM
CN1CCN(c2cc(C(F)(F)F)ccc2N2CCOc3cc(S(=O)(=O)Nc4nccs4)ccc32)CC1 CHEMBL3900428 IC50 957.0 nM
CC(C)(C)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1 CHEMBL17157 IC50 971.0 nM
O=C(COc1cccc2cccnc12)Nc1ccccc1N1CCOCC1 CHEMBL1480490 IC50 980.0 nM
CN1CCN(c2cc(C(F)(F)F)ccc2[C@H]2CCOc3cc(S(=O)(=O)Nc4nccs4)ccc32)CC1 CHEMBL4632456 IC50 983.0 nM