CNc1ncc2cc(-c3ccc(-c4ncccc4F)cc3Cl)c(=O)n(C[C@H]3OC[C@H](N)CO3)c2n1 CHEMBL5090394 IC50 0.3 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.345 nM
CCc1nnc(-c2c(OC)cc(-c3cnc4cc(-c5cnn(C)c5)ccn34)cc2OC)o1 CHEMBL5407103 IC50 0.4 nM
COc1cc(-c2cnc(Nc3cc(N4CCN(C)CC4)nc(C)n3)s2)cc2c1C(=O)N(CC(F)(F)F)CC2 CHEMBL5394880 IC50 0.6 nM
COc1ccc(N(C(=O)Nc2c(C)cccc2C)c2cc(Nc3ccc(N4CCN(C)CC4)cc3)ncn2)c(OC)c1 CHEMBL4553284 IC50 0.6 nM
COc1cc(-c2cnc(Nc3cc(N4CCN(C)CC4)nc(C)n3)s2)cc2c1C(=O)N(CC#N)CC2 CHEMBL5430450 IC50 0.61 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 0.631 nM
COc1cc(-c2cnc(Nc3cc(N4CCN(CCO)CC4)nc(C)n3)s2)cc2c1C(=O)N(CC(F)(F)F)CC2 CHEMBL5426204 IC50 0.64 nM
COc1cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)cc(OC(F)F)c1C(=O)NC1CC1 CHEMBL5417444 IC50 0.7 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL5416410 pKi 0.7943 nM
CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(N)=O)c(OC)c2)cn1 CHEMBL5438171 IC50 0.9 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 1.0 nM
COc1ccc(-c2c[nH]c3nccc(-c4ccsc4)c23)c(OC)c1 CHEMBL4539742 IC50 1.0 nM
COc1cc(-c2cnc3cc(OCCC4CCOCC4)ccn23)cc(OC(F)F)c1C(=O)NC1CC1 CHEMBL5440720 IC50 1.6 nM
COc1cc(-c2cnc(Nc3cc(N4CCOCC4)nc(C)n3)s2)cc2c1C(=O)N(CC(F)(F)F)CC2 CHEMBL5421558 IC50 1.9 nM
CN1CC(Oc2cnc(C#N)cc2-c2ccn3nc(NC(=O)C4CC4)cc3c2)C1 CHEMBL5405960 IC50 1.9 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12 CHEMBL400402 Kd apparent 2.0 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(Cl)csc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL4859969 IC50 2.0 nM
CCNC(=O)c1c(OC)cc(-n2cnc3cc(-c4cnn(CC)c4)ccc32)cc1OC(F)F CHEMBL5431938 IC50 2.3 nM
CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(CO)c(OC)c2)cn1 CHEMBL5427025 IC50 2.4 nM
CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(=O)NC3CC3)c(OC)c2)cn1 CHEMBL5412961 IC50 2.5 nM
COc1cc(-c2cnc3cc(N4CCC(N(C)C)CC4)ccn23)cc(OC(F)F)c1C(=O)NC1CC1 CHEMBL5405883 IC50 2.6 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 3.0 nM
CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(=O)NCC(F)(F)F)c(OC)c2)cn1 CHEMBL5404502 IC50 3.3 nM
CCNC(=O)c1c(OC)cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)cc1OC(F)F CHEMBL5415380 IC50 3.3 nM
CCNC(=O)c1c(OC)cc(-n2cnc3cc(-c4cnn(CC#N)c4)ccc32)cc1OC CHEMBL5397288 IC50 3.9 nM
N[C@H]1CC[C@@H](Nc2cc[nH]c(=O)c2-c2nc3ccccc3[nH]2)CC1 CHEMBL3780091 IC50 4.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 4.0 nM
CNc1ncc2cc(-c3ccc(-c4cccc(C)n4)cc3Cl)c(=O)n(C[C@H]3OC[C@H](N)CO3)c2n1 CHEMBL3770443 IC50 4.4 nM
COc1cc(-c2cnc3cc(OCCN4CCOCC4)ccn23)cc(OC(F)F)c1C(=O)NC1CC1 CHEMBL5437300 IC50 4.8 nM
COc1cc(-c2cnc(Nc3cc(CN4CCOCC4)ccn3)s2)cc2c1C(=O)N(CC(F)(F)F)CC2 CHEMBL5420653 IC50 5.3 nM
COc1cc(-c2cnc3cc(N4CCN(CCO)CC4)ccn23)cc(OC(F)F)c1C(=O)NC1CC1 CHEMBL5410472 IC50 5.3 nM
COc1cc(-c2cnc3cc(N4CCN(C)CC4)ccn23)cc(OC(F)F)c1C(=O)NC1CC1 CHEMBL5419090 IC50 5.4 nM
COc1cc(-c2cnc3cc(N4CC(F)(F)C4)ccn23)cc(OC(F)F)c1C(=O)NC1CC1 CHEMBL5439455 IC50 5.7 nM
CCCCNc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL3326006 IC50 5.75 nM
COc1cc(-c2cnc3cc(N4CCN(C(C)=O)CC4)ccn23)cc(OC(F)F)c1C(=O)NC1CC1 CHEMBL5402124 IC50 5.9 nM
Cc1cccc(F)c1NC(=O)c1cnc(Nc2ccc(N3CCN(C)CC3)c(F)c2)nc1NC1CC1 CHEMBL5438704 IC50 6.0 nM
COc1ccc(N2C(=O)N(c3c(C)cccc3Cl)Cc3cnc(Nc4ccc(N5CCN(C)CC5)cc4)nc32)nc1 CHEMBL5422800 IC50 6.0 nM
COc1cc(-c2cnc(Nc3cc(CN4CCOCC4=O)ccn3)s2)cc2c1C(=O)N(CC(F)(F)F)CC2 CHEMBL5415835 IC50 6.4 nM
COc1cc(-c2cnc(Nc3cccc(OCCN(C)C)n3)s2)cc2c1C(=O)N(CC(F)(F)F)CC2 CHEMBL5407084 IC50 6.6 nM
NC(=O)Nc1cc(-c2cccc(F)c2)sc1C(=O)N[C@H]1CCCNC1 CHEMBL2041933 Kd apparent 7.0 nM
CCN1CCN(Cc2ccc(Nc3nccc(-c4cnc(N5CC[C@H](F)C5)c(C#N)c4)n3)cn2)CC1 CHEMBL4295211 INH 7.0 nM
COc1cc(-c2cnc(Nc3cc(N4CCOCC4)ccn3)s2)cc2c1C(=O)N(CC(F)(F)F)CC2 CHEMBL5415567 IC50 7.8 nM
COc1cc(-c2cnc3cc(OCCN4CCOCC4)ccn23)cc2c1C(=O)N(CC(F)(F)F)CC2 CHEMBL5393771 IC50 7.8 nM
CCNC(=O)c1c(OC)cc(-n2cnc3cc(-c4cnn(CC)c4)ccc32)cc1OC CHEMBL5401167 IC50 7.9 nM
Cc1cccc(F)c1NC(=O)c1cnc(Nc2ccc(N3CCN(C)CC3)c(F)c2)nc1NC1CCC1 CHEMBL5408557 IC50 8.0 nM
CCNC(=O)c1c(OC)cc(-n2cnc3cc(-c4cnn(C5CCOCC5)c4)ccc32)cc1OC CHEMBL5396179 IC50 9.2 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(Cl)csc3C)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL4847716 IC50 10.0 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)csc3Cl)s2)cc(N2CCN(C)CC2)n1 CHEMBL4875238 IC50 10.0 nM
COc1cc(-c2cnc3cc(N4CC(N(C)C)C4)ccn23)cc(OC(F)F)c1C(=O)NC1CC1 CHEMBL5410109 IC50 10.1 nM
CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(=O)NC)c(OC)c2)cn1 CHEMBL5415699 IC50 10.5 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 Kd apparent 11.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL574737 Kd apparent 11.0 nM
CCNC(=O)c1c(OC)cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)cc1OC CHEMBL5403558 IC50 11.2 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)csc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL4867844 IC50 11.7 nM
CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(S(C)(=O)=O)ncc21 CHEMBL5199998 IC50 12.0 nM
CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3cccc(CN4CCCC4)c3)ncc21 CHEMBL5305160 IC50 12.0 nM
COc1cc(-c2cnc3cc(NCCN4CCOCC4)ccn23)cc(OC(F)F)c1C(=O)NC1CC1 CHEMBL5430610 IC50 14.1 nM
CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(=O)OC)c(OC)c2)cn1 CHEMBL5430774 IC50 14.4 nM
CCNC(=O)c1c(OC)cc(-n2cnc3cc(-c4cnn(CCOC)c4)ccc32)cc1OC CHEMBL5395705 IC50 14.4 nM
CCNC(=O)c1c(OC)cc(-n2cnc3cc(-c4cnn(CCO)c4)ccc32)cc1OC CHEMBL5420455 IC50 14.6 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 15.0 nM
COc1cc(-c2cnc(Nc3nc(C)nc(N4CCN(C)CC4)c3F)s2)cc2c1C(=O)N(CC(F)(F)F)CC2 CHEMBL5434195 IC50 15.0 nM
COc1cc(-c2cnc3cc(N4CCOCC4)ccn23)cc(OC(F)F)c1C(=O)NC1CC1 CHEMBL5424512 IC50 15.8 nM
Cc1cccc(Nc2nc(NC3CCCCC3N)cnc2C(N)=O)c1 CHEMBL1974328 pKi 15.85 nM
CC1(COc2ccc3c(c2)ncn3-c2ccc3cccc(N4CCC(N)CC4)c3n2)COC1 CHEMBL2105728 Kd apparent 16.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 17.0 nM
CCNC(=O)c1c(OC)cc(-n2cnc3cc(-c4cnn(CC(N)=O)c4)ccc32)cc1OC CHEMBL5419476 IC50 20.1 nM
CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(=O)O)c(OC)c2)cn1 CHEMBL5428147 IC50 20.6 nM
COc1cc(-c2cnc3cc(N4CC(F)(F)C4)ccn23)cc(OC)c1C(=O)NCC(F)(F)F CHEMBL5440381 IC50 22.7 nM
COc1cc(-c2cnc(Nc3ccccn3)s2)cc2c1C(=O)N(CC(F)(F)F)CC2 CHEMBL5434893 IC50 23.0 nM
CC(=O)N1CCN(c2cc(Nc3ncc(C(=O)Nc4c(C)csc4Cl)s3)nc(C)n2)CC1 CHEMBL4865466 IC50 25.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 pKi 25.12 nM
CC(C)(C)n1nc(-c2ccc(Cl)cc2)c2c(N)ncnc21 CHEMBL406845 pKi 25.12 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 26.0 nM
COc1cc(-c2cnc3cc(Nc4cccc(N5CCOCC5)c4)ccn23)cc(OC(F)F)c1C(=O)NC1CC1 CHEMBL5399976 IC50 26.4 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 Kd 29.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 30.0 nM
CNc1ncc2cc(-c3cc(F)c(-c4cccc(C)n4)cc3F)c(=O)n(CCCCN)c2n1 CHEMBL5402213 IC50 31.0 nM
COc1cc(-c2cnc3cc(Nc4cn(C)cn4)ccn23)cc(OC(F)F)c1C(=O)NC1CC1 CHEMBL5399855 IC50 32.3 nM
COc1cc(-c2cnc3cc(N4CCN(C)CC4)ccn23)cc(OC)c1C(=O)NCC(F)(F)F CHEMBL5421593 IC50 35.5 nM
COc1ccc(N2C(=O)N(c3c(C)cccc3Cl)Cc3cnc(Nc4ccc(C5CCN(C)CC5)cc4OC)nc32)nc1 CHEMBL5209511 IC50 40.0 nM
Cn1cc(C2=Nc3cc(NC(=O)C(N)C4CCCCC4)cc4c3C2=CNNC4=O)cn1 CHEMBL3545137 Kd apparent 47.0 nM
COc1cccc(Nc2ncnn3ccc(CN4CC[C@@H](N)[C@H](O)C4)c23)c1 CHEMBL3545396 Kd apparent 48.0 nM
COc1cc(-c2cnc3cc(NC(=O)C4CCOCC4)ccn23)cc(OC(F)F)c1C(=O)NC1CC1 CHEMBL5410039 IC50 48.3 nM
COc1cc(-c2cnc3cc(OCCN4CCOCC4)ccn23)cc2c1C(=O)N(C1CC1)CC2 CHEMBL5412411 IC50 52.2 nM
COCCC(=O)Nc1ccn2c(-c3cc(OC)c(C(=O)NC4CC4)c(OC(F)F)c3)cnc2c1 CHEMBL5414213 IC50 54.8 nM
COc1cc(-c2cnc3cc(N4CCOCC4)ccn23)cc(OC)c1C(=O)NCC(F)(F)F CHEMBL5426058 IC50 56.8 nM
COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL281948 Kd apparent 58.0 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(Cl)ccnc3C)s2)cc(NN2CCN(CCO)CC2)n1 CHEMBL4855726 IC50 60.0 nM
O=C(NCCCNc1nc(Nc2cccc(CN3CCOCC3)c2)ncc1C1CC1)C1CCC1 CHEMBL3605057 IC50 67.0 nM
CNc1ncc2cc(-c3ccccc3Cl)c(=O)n(CCCCN)c2n1 CHEMBL5401391 IC50 74.0 nM
CNc1ncc2cc(-c3cc(F)ccc3F)c(=O)n(CCCCN)c2n1 CHEMBL5425418 IC50 89.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL1240703 Kd 90.0 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 Kd 98.0 nM
COc1cc(-n2cnc3cc(Br)ccc32)cc(OC)c1C(N)=O CHEMBL5428443 IC50 98.8 nM
Oc1cc(O)cc(C=Cc2ccc(O)c(O)c2)c1 CHEMBL1972346 pKi 100.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 pKi 100.0 nM
CNC(=O)c1nn(C)c2c1C(C)(C)Cc1cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc1-2 CHEMBL564829 Kd apparent 110.0 nM
O=C(NC1CC1)c1ncc(-c2cnc3cc(OCCN4CCOCC4)ccn23)cc1OC(F)F CHEMBL5417256 IC50 113.8 nM
CCS(=O)(=O)c1cccc(-c2cc(C(=O)NC3CCN(C)CC3)c(C)c3[nH]c4ncc(C)cc4c23)c1 CHEMBL3544932 Kd apparent 115.0 nM
COc1cc(-n2cnc3cc(N4CCOCC4)ccc32)cc(OC)c1C(=O)NCC(F)(F)F CHEMBL5439601 IC50 116.8 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cncc3C)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL4857583 IC50 119.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd apparent 122.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncnc(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL3545360 Kd apparent 123.0 nM
CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5ccncc5)ccc4n3)cc2)CC1 CHEMBL4531334 IC50 125.0 nM
CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL3991929 Kd apparent 128.0 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cncc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL4869199 IC50 130.0 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(Cl)ccnc3C)s2)cc(N2CCN(C)CC2)n1 CHEMBL4851745 IC50 138.0 nM
COc1cc(-c2cnc3ccccn23)cc2c1C(=O)N(CC(F)(F)F)CC2 CHEMBL5436223 IC50 140.0 nM
COc1ccccc1Nc1nccc(-c2cc3c(c(OC)c2)C(=O)N(CC(F)(F)F)CC3)n1 CHEMBL5428150 IC50 150.0 nM
COc1cc(-c2cnc3cc(OCCN4CCOCC4)ccn23)cnc1C(=O)NC1CC1 CHEMBL5436639 IC50 155.9 nM
c1cc(CN2CCOCC2)cc(Nc2nccc(NCCc3cnc[nH]3)n2)c1 CHEMBL5085698 IC50 185.0 nM
CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL1084546 pKi 199.53 nM
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL601719 Kd 200.0 nM
COCCN1CCN(Cc2ccc(-c3n[nH]c4c3C(=O)c3c(NC(=O)NN5CCOCC5)cccc3-4)cc2)CC1 CHEMBL3545083 Kd apparent 207.0 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)noc3C)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL4850733 IC50 232.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 240.0 nM
COc1cc(-c2cnc3cc(OCCN4CCOCC4)ccn23)cnc1C(=O)NCC(F)(F)F CHEMBL5410461 IC50 240.8 nM
NC(=O)c1ccc(NC2CCCCC2N)nc1Nc1cccc(Cl)c1 CHEMBL1982753 pKi 251.19 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 251.19 nM
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=O)c1c(F)cccc1F CHEMBL191003 pKi 251.19 nM
Cn1cc(-c2cnn3c(N)c(Br)c([C@@H]4CCCNC4)nc23)cn1 CHEMBL2386889 Kd apparent 270.0 nM
O=C(Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1)C1CCCN1 CHEMBL3545328 Kd apparent 300.0 nM
COc1cc(-n2cnc3cc(Br)ccc32)ccc1C(N)=O CHEMBL5417490 IC50 300.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc32)c1C CHEMBL1990885 pKi 316.23 nM
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 CHEMBL939 pKi 316.23 nM
COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C)cc(OC)c1OC CHEMBL4517408 IC50 336.0 nM
Cc1nc(Nc2ncc(C(=O)Nc3cccnc3C)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL4872654 IC50 385.0 nM
OC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1991674 pKi 398.11 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 400.0 nM
Cc1nc(Nc2ncc(C(=O)Nc3ncccc3C)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL4865214 IC50 427.0 nM
COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 CHEMBL24828 Kd 430.0 nM
Cc1nc(NCCO)cc(Nc2ncc(C(=O)Nc3c(Cl)ccnc3C)s2)n1 CHEMBL4857318 IC50 470.0 nM
O=C(NCCCNc1ccnc(Nc2cccc(NC(=O)N3CCCC3)c2)n1)C1CCC1 CHEMBL5075360 IC50 481.0 nM
c1ccc(-c2c[nH]c3ncnc(N4CCCCC4)c23)cc1 CHEMBL1998953 pKi 501.19 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 520.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 560.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 560.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 580.0 nM
CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(=O)N(C)C3CC3)c(OC)c2)cn1 CHEMBL5410107 IC50 597.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl CHEMBL458997 pKi 630.96 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 640.0 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)ccnc3C)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL4878274 IC50 641.0 nM
CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1 CHEMBL2028663 Kd apparent 649.0 nM
CNc1ncc2cc(-c3cc(Cl)ccc3Cl)c(=O)n(CCCCN)c2n1 CHEMBL5416418 IC50 665.0 nM
CCn1cc(-c2ccnc3[nH]c(-c4cccc(CN(C)C)c4)cc23)c(-c2ccc(NC(=O)N(C)C)cc2)n1 CHEMBL1090479 Kd apparent 685.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 750.0 nM
N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL1078178 Kd apparent 790.0 nM
NC(=O)c1c(OCc2c(F)cc(Br)cc2F)nsc1NC(=O)NCCCCN1CCCC1 CHEMBL253969 Kd apparent 904.0 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL572878 pKi 1000.0 nM
C[S+]([O-])c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL10 pKi 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM