Cc1nc2nc(C)c(C[C@@H]3CCN(c4ccc(-c5cnc(CN6CCOCC6)cn5)cc4)C3)c(C)n2n1 CHEMBL5419465 IC50 0.23 nM
Cc1nc2nc(C)c(C[C@@H]3CCN(c4ccc(-c5ccc(CN6CCOCC6)nn5)cc4)C3)c(C)n2n1 CHEMBL5399511 IC50 0.29 nM
CCn1ncc2ccc(-c3cc(CO[C@](C)(CC)C(=O)O)nn3-c3ccccc3N3CCCC3)cc21 CHEMBL5268154 IC50 0.3 nM
CC[C@@](C)(OCc1cc(-c2cccc(OC3CC3)c2)n(-c2ccccc2N2CCC2)n1)C(=O)O CHEMBL5267318 IC50 0.36 nM
CCCn1ncc2ccc(-c3cc(CO[C@](C)(CC)C(=O)O)nn3-c3ccccc3N3CCC3)cc21 CHEMBL5270910 IC50 0.57 nM
Cc1nc2nc(C)c(C[C@@H]3CCN(c4ccc(-c5ccc(CN6CCN(C)CC6)nn5)cc4)C3)c(C)n2n1 CHEMBL5425432 IC50 0.91 nM
CCOc1ccc(S(=O)(=O)Nc2ccc(Cl)cc2C#Cc2cnc(C(=O)O)cc2OC)c2ncccc12 CHEMBL4802043 IC50 1.0 nM
CC(C)(OCc1cc(-c2ccccc2)n(Cc2ccccc2)n1)C(=O)O CHEMBL5219543 IC50 1.0 nM
Oc1cccc(C(O)CNCc2ccc(-c3ccccc3)cc2)c1 CHEMBL1616099 IC50 1.0 nM
CCOC(=O)Oc1c(OC)cc(C(=O)O[C@@H]2C[C@@H]3CN4CCc5c([nH]c6cc(OC)ccc56)[C@H]4C[C@@H]3[C@H](C(=O)OC)[C@H]2OC)cc1OC CHEMBL1399124 IC50 1.0 nM
Cc1nc2nc(C)c(O[C@@H]3CCN(c4ccc(-c5ccc(CN6CCOCC6)nn5)cc4)C3)c(C)n2n1 CHEMBL5434099 IC50 1.3 nM
Cc1nc2nc(C)c(C[C@@H]3CCN(c4cnc(-c5ccc(CN6CCN(C)CC6)cc5)cn4)C3)c(C)n2n1 CHEMBL5407216 IC50 1.7 nM
Cc1n[nH]c(C)c1Cc1sc2c(c1C(=O)N1C[C@H](O)CO1)c(=O)n(C)c(=O)n2CC(C)C CHEMBL375166 IC50 2.5 nM
CC(=O)N1CCN(Cc2ccc(-c3ccc(N4CC[C@@H](Oc5c(C)nc6nc(C)nn6c5C)C4)cc3)nn2)CC1 CHEMBL5414818 IC50 2.5 nM
Cc1nc2nc(C)c(O[C@@H]3CCN(c4ccc(-c5ccc(CN6CCN(C)CC6)nn5)cc4)C3)c(C)n2n1 CHEMBL5416221 IC50 3.1 nM
Cc1nc2nc(C)c(CCNC(=O)c3nnc(-c4ccccc4)s3)c(C)n2n1 CHEMBL5417798 IC50 5.6 nM
Cc1nc2nc(C)c(CCNC(=O)c3cnc(-c4ccc([C@H]5COCCN5C)cc4)cn3)c(C)n2n1 CHEMBL5403188 IC50 6.3 nM
Cc1nc2nc(C)c(CCNC(=O)c3cnc(-c4ccc(CN5CCOCC5)cc4)cn3)c(C)n2n1 CHEMBL5427454 IC50 6.8 nM
Cc1[nH]nc(C(F)(F)F)c1Cc1sc2c(c1C(=O)N1C[C@](C)(O)CO1)c(=O)n(C)c(=O)n2C(C)C CHEMBL3335793 IC50 7.1 nM
CC1(CCCCCC(=O)NCCOCCOCCOCCOc2ccnc3c(S(=O)(=O)Nc4ccccc4C#Cc4ccc(C(=O)O)nc4)cccc23)C(/C=C/C=C/C=C2\N(CCCS(=O)(=O)O)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCS(=O)(=O)[O-])c2ccc(S(=O)(=O)O)cc21 CHEMBL5282978 Ke 9.6 nM
CN(Cc1ccccc1)c1ccc2cc(C(=O)O)c(=O)oc2c1 CHEMBL2442509 IC50 10.0 nM
COc1ccc(S(=O)(=O)Nc2ccccc2C#Cc2cnc(C(=O)O)c(C)c2)c2ncccc12 CHEMBL5276884 Ki 11.0 nM
COc1ccc(S(=O)(=O)Nc2ccccc2C#Cc2ccc(C(=O)O)nc2)c2ncccc12 CHEMBL5282741 IC50 13.0 nM
CCCCN(CCCC)c1ccc(/C=C(\C#N)C(=O)O)c(OC)c1 CHEMBL3582419 IC50 14.0 nM
CCOc1ccc(S(=O)(=O)Nc2ccccc2C#Cc2ccc(C(=O)O)nc2)c2ncccc12 CHEMBL5279064 Ki 16.0 nM
Cc1nc2nc(C)c(CCNC(=O)c3ccc(-c4ccccc4)cc3)c(C)n2n1 CHEMBL5397310 IC50 16.0 nM
Cc1nc2nc(C)c(CCNC(=O)c3cnc(-c4ccc([C@@H]5COCCN5C)cc4)cn3)c(C)n2n1 CHEMBL5397546 IC50 16.0 nM
COc1cc(N(CC(C)C)CC(C)C)ccc1/C=C(\C#N)C(=O)O CHEMBL3582420 IC50 17.0 nM
Cc1ccc2cccnc2c1S(=O)(=O)Nc1ccccc1C#Cc1ccc(C(=O)O)nc1 CHEMBL5267752 Ki 17.0 nM
CCOc1ccc(S(=O)(=O)Nc2ccccc2C#Cc2cnc(C(=O)O)cc2OC)c2ncccc12 CHEMBL5267349 Ki 17.0 nM
CCOc1ccc(S(=O)(=O)Nc2ccccc2C#Cc2cnc(C(=O)O)c(NC)c2)c2ncccc12 CHEMBL5281492 Ki 17.0 nM
COc1ccc(S(=O)(=O)Nc2ccccc2C#Cc2ccc(C(=O)O)cc2)c2ncccc12 CHEMBL5287835 IC50 21.0 nM
COc1cc(N(c2ccccc2)c2ccccc2)ccc1/C=C(\C#N)C(=O)O CHEMBL3582422 IC50 23.0 nM
Cc1nc2nc(C)c(CCNC(=O)c3cnc(-c4ccccc4)cn3)c(C)n2n1 CHEMBL5405297 IC50 27.0 nM
Cc1cnc2c(S(=O)(=O)Nc3ccccc3C#Cc3ccc(C(=O)O)nc3)cccc2c1 CHEMBL5287351 Ki 29.0 nM
COc1cc(N(Cc2ccccc2)Cc2ccccc2)ccc1/C=C(\C#N)C(=O)O CHEMBL3892299 IC50 32.0 nM
Cc1ccnc2c(S(=O)(=O)Nc3ccccc3C#Cc3ccc(C(=O)O)nc3)cccc12 CHEMBL5287780 Ki 32.0 nM
O=C(O)c1ccc(C#Cc2ccccc2NS(=O)(=O)c2cccc3cccnc23)cn1 CHEMBL5268966 Ki 37.0 nM
O=C(O)c1ccc(C#Cc2ccccc2NS(=O)(=O)c2cccc3c(OCCOCCOc4ccccc4)ccnc23)cn1 CHEMBL5280923 IC50 40.0 nM
CNc1cc(C#Cc2ccccc2NS(=O)(=O)c2c(C)ccc3cccnc23)ccc1C(=O)O CHEMBL5290111 IC50 50.0 nM
Cc1cc(S(=O)(=O)Nc2ccccc2C#Cc2ccc(C(=O)O)nc2)c2ncccc2c1 CHEMBL5288904 Ki 51.0 nM
COc1cc(N2CCCC2)ccc1/C=C(\C#N)C(=O)O CHEMBL3582500 IC50 53.0 nM
Cc1cc(C#Cc2ccccc2NS(=O)(=O)c2c(C)ccc3cccnc23)cnc1C(=O)O CHEMBL5265956 Ki 56.0 nM
COc1cc(N2CCCCC2)ccc1/C=C(\C#N)C(=O)O CHEMBL3582501 IC50 58.0 nM
Cc1nc2nc(C)c(CCC(=O)Nc3nnc(-c4ccccc4)s3)c(C)n2n1 CHEMBL5414505 IC50 84.0 nM
CCCCCN(CCCCC)c1ccc(/C=C(\C#N)C(=O)O)c(OC)c1 CHEMBL3582421 IC50 85.0 nM
Cc1ccc2cccc(S(=O)(=O)Nc3ccccc3C#Cc3ccc(C(=O)O)nc3)c2n1 CHEMBL5266104 Ki 99.0 nM
Cc1ccc(F)cc1S(=O)(=O)Nc1ccccc1CCc1cccc(C(=O)O)c1 CHEMBL5284913 IC50 100.0 nM
Cc1ccc2cccnc2c1S(=O)(=O)Nc1ccccc1C#Cc1ccc(C(=O)O)cc1 CHEMBL5291399 IC50 100.0 nM
Cc1nc2ncnn2c(C)c1CCC(=O)Nc1nnc(-c2ccc(C(C)C)cc2)s1 CHEMBL5400561 IC50 167.0 nM
O=C(O)c1ccc(C#Cc2ccccc2NS(=O)(=O)c2cccc3ccccc23)c(F)c1 CHEMBL5280358 IC50 200.0 nM
O=C(O)c1ccc(C#Cc2ccccc2NS(=O)(=O)c2cccc3cccnc23)cc1 CHEMBL5278014 IC50 200.0 nM
Cc1ccc(S(=O)(=O)Nc2ccccc2C#Cc2ccc(C(=O)O)nc2)c2ncccc12 CHEMBL5271816 Ki 222.0 nM
O=C(O)c1ccc(C#Cc2ccccc2NS(=O)(=O)c2cccc3c(OCCOCCOCCOCCCCCCOCc4ccccc4)ccnc23)cn1 CHEMBL5268302 IC50 240.0 nM
CCN(CC)c1ccc2cc(C(=O)O)c(=O)oc2c1 CHEMBL1303766 IC50 250.0 nM
O=C(O)c1cccc(CCc2ccccc2NS(=O)(=O)c2cc(Cl)ccc2Cl)c1 CHEMBL5289504 IC50 300.0 nM
COc1cc(C#Cc2ccccc2NS(=O)(=O)c2c(C)ccc3cccnc23)ccc1C(=O)O CHEMBL5274725 IC50 300.0 nM
O=C(O)c1ccc(C#Cc2ccccc2NS(=O)(=O)c2cccc3ccccc23)cc1 CHEMBL5291036 IC50 400.0 nM
Cc1nc2ncnn2c(C)c1CCC(=O)Nc1nnc(-c2ccccc2)s1 CHEMBL5422617 IC50 474.0 nM
O=C(O)c1ccccc1CCCCCc1ccccc1NC(=O)c1cccc2ccccc12 CHEMBL5289665 IC50 500.0 nM
COc1cc(C(=O)O)ncc1C#Cc1ccccc1NS(=O)(=O)c1cccc2c(N(C)C)ccnc12 CHEMBL4802046 IC50 506.0 nM
O=C(O)c1ccc(C#Cc2ccccc2NS(=O)(=O)c2cccc3c(OCCOCCOc4ccc([N+](=O)[O-])cc4)ccnc23)cn1 CHEMBL5284412 IC50 570.0 nM
O=C(Nc1ccccc1CCCCCc1ccccc1C(=O)O)c1ccc2ccccc2c1 CHEMBL5280178 IC50 600.0 nM
COc1ccc(S(=O)(=O)Nc2ccccc2C#Cc2ccc(C(=O)O)cc2)c(C)c1C CHEMBL5266150 IC50 600.0 nM
O=C(O)c1ccc(C#Cc2ccccc2NS(=O)(=O)c2c(Cl)cccc2Cl)cc1 CHEMBL5281466 IC50 600.0 nM
O=C(O)c1cccc(C#Cc2ccccc2NS(=O)(=O)c2ccc3ccccc3c2)c1 CHEMBL5282350 IC50 700.0 nM
O=C(O)c1cc2cc3c4c(c2oc1=O)CCCN4CCC3 CHEMBL2442512 IC50 730.0 nM
COc1ccc(S(=O)(=O)Nc2ccccc2CCc2cccc(C(=O)O)c2)c(C)c1C CHEMBL5285385 IC50 800.0 nM
O=C(O)c1ccc(C#Cc2ccccc2NS(=O)(=O)c2ccc3ccccc3c2)cc1 CHEMBL5280269 IC50 800.0 nM
O=C(O)c1cccc(/C=C/c2ccccc2NS(=O)(=O)c2ccc3ccccc3c2)c1 CHEMBL5271238 IC50 900.0 nM
CC(C)(C)OC(=O)NCCOCCOCCOCCOc1ccnc2c(S(=O)(=O)Nc3ccccc3C#Cc3ccc(C(=O)O)nc3)cccc12 CHEMBL5279333 IC50 960.0 nM
O=C(O)c1ccc(C#Cc2ccccc2NS(=O)(=O)c2ccc3ccccc3c2)cn1 CHEMBL5272725 IC50 1000.0 nM