COc1ccc(F)cc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 CHEMBL3780239 IC50 1.0 nM
Cc1c(NC(=O)c2cc(C(N)=O)nc3cc(F)ccc23)c(C(F)(F)F)nn1Cc1ccc(C#N)cc1 CHEMBL4448899 IC50 2.0 nM
COc1ccccc1N1CCCN(c2ncnc3c2cnn3-c2ccccc2)CC1 CHEMBL3781913 IC50 4.0 nM
C/C=C(\C)[C@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H](C)/C=C(C)/C=C/C/C(C)=C/Cc1nc(OC)c(OC)c(O)c1C CHEMBL4092369 IC50 4.9 nM
COc1ccc(C(N)=O)cc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 CHEMBL3781331 IC50 5.0 nM
Oc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 CHEMBL3781149 IC50 7.0 nM
COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2F)CC1 CHEMBL3781548 IC50 7.0 nM
COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2cc(F)cc(F)c2)CC1 CHEMBL3780460 IC50 8.0 nM
COc1ccncc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 CHEMBL3780372 IC50 9.0 nM
COc1cc(F)ccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 CHEMBL3780972 IC50 10.0 nM
COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2C)CC1 CHEMBL3781347 IC50 10.0 nM
COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1C CHEMBL3781308 IC50 14.0 nM
COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccc(F)cc2)CC1 CHEMBL3781151 IC50 17.0 nM
COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccc(C#N)cc2)CC1 CHEMBL3781194 IC50 17.0 nM
COc1ccc(C#N)cc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 CHEMBL3780144 IC50 20.0 nM
COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 CHEMBL3781157 IC50 25.0 nM
N#Cc1ccccc1-c1ccc2nc(-c3ccc(Cl)cc3)c(CN3CCN(C(=O)c4cccc(F)c4)CC3)n2c1 CHEMBL4289139 pIC50 25.7 nM
COc1ccccc1N1CCN(c2ncnc3c2ncn3-c2ccccc2)CC1 CHEMBL3780785 IC50 27.0 nM
COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2cc(F)ccc2OC)CC1 CHEMBL3780470 IC50 30.0 nM
COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2cccc(C#N)c2)CC1 CHEMBL3780765 IC50 33.0 nM
COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2cccc(F)c2)CC1 CHEMBL3781741 IC50 35.0 nM
CN1CCN(c2cnc3c(C4CCN(C(=O)c5ccc(OC(F)(F)F)cc5N)CC4)ncnc3c2)CC1 CHEMBL4445670 IC50 35.0 nM
CC(C)(C)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COCC3)c1 CHEMBL4647311 IC50 36.0 nM
CCC(C)(C)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COC3)c1 CHEMBL4645691 IC50 37.0 nM
CN(C)c1ccc(C(O)(c2ccc(N(C)C)cc2)c2ccc(N(C)C)cc2)cc1 CHEMBL592105 IC50 38.0 nM
N#Cc1cccc(N2CCN(c3ncnc4c3cnn4-c3ccccc3)CC2)c1 CHEMBL3780717 IC50 39.0 nM
COc1ccccc1N1CCN(c2ncnc3c2cnn3C2CCCC2)CC1 CHEMBL3780527 IC50 40.0 nM
CCC(CC)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COCC3)c1 CHEMBL4634839 IC50 48.0 nM
COc1ccccc1N1CCN(c2ncnc3c2nnn3-c2ccccc2)CC1 CHEMBL3781384 IC50 49.0 nM
COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2OC)CC1 CHEMBL3780235 IC50 50.0 nM
COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2cccc(C)c2)CC1 CHEMBL3780043 IC50 50.0 nM
COc1ccccc1N1CCN(c2ncnc3c2[nH]c(=O)n3-c2ccccc2)CC1 CHEMBL3780054 IC50 53.0 nM
COc1cccnc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 CHEMBL3781835 IC50 60.0 nM
CCC1=C(CC2NCCc3cc(OC)c(OC)cc32)CC2c3cc(OC)c(OC)cc3CCN2C1 CHEMBL547470 IC50 63.0 nM
CC1(NC(=O)COc2cccc(-c3nc4c(c(Nc5ccc(-c6cn[nH]c6)cc5)n3)CN(C3CC3)CC4)c2)CC1 CHEMBL4645036 IC50 72.0 nM
COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ncccc2F)CC1 CHEMBL3781535 IC50 80.0 nM
C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](O)[C@H](OC(=O)NCCCCCCCNC(=O)CCc3ccc(O)cc3)[C@@]2(C)O1 CHEMBL111738 Kd 100.0 nM
COc1ccc(-n2ncc3c(N4CCN(c5ccccc5OC)CC4)ncnc32)cn1 CHEMBL3780595 IC50 100.0 nM
O=C(COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COC3)c1)NC1CCCC1 CHEMBL4634011 IC50 102.0 nM
CC(CF)N1CCc2nc(-c3cccc(OCC(=O)NC(C)(C)C)c3)nc(Nc3ccc(-c4cn[nH]c4)cc3)c2C1 CHEMBL4649311 IC50 105.0 nM
CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21 CHEMBL50588 IC50 108.0 nM
COc1cccc(F)c1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 CHEMBL3781654 IC50 110.0 nM
COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)C(C)C1 CHEMBL3781633 IC50 120.0 nM
CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2c1cc(OC)c(O)c2Cl CHEMBL535077 IC50 122.0 nM
COCC(C)N1CCc2nc(-c3cccc(OCC(=O)NC(C)(C)C)c3)nc(Nc3ccc(-c4cn[nH]c4)cc3)c2C1 CHEMBL4642046 IC50 128.0 nM
COc1ccc(CC(=O)N[C@@H](Cc2ccccc2Br)C(=O)N[C@@H](C)c2ccccc2)cc1 CHEMBL4089982 IC50 140.0 nM
CC(C)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)CN(C2CC2)CC3)c1 CHEMBL4645662 IC50 140.0 nM
COCCN1CCc2nc(-c3cccc(OCC(=O)NC(C)(C)C)c3)nc(Nc3ccc(-c4cn[nH]c4)cc3)c2C1 CHEMBL4638542 IC50 143.0 nM
COc1cc(C#N)ccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 CHEMBL3781183 IC50 150.0 nM
CC(C)(C)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)CN(C2CCOC2)CC3)c1 CHEMBL4634012 IC50 161.0 nM
O=C(COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COC3)c1)NC1CCC1 CHEMBL4638234 IC50 179.0 nM
COc1cccc(N2CCN(c3ncnc4c3cnn4-c3ccccc3)CC2)c1 CHEMBL3781827 IC50 180.0 nM
COc1ncccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 CHEMBL3780764 IC50 180.0 nM
CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2c1cc(OC)c(O)c2I CHEMBL535750 IC50 192.0 nM
COc1cccc(-n2ncc3c(N4CCN(c5ccccc5OC)CC4)ncnc32)c1 CHEMBL3780772 IC50 200.0 nM
Nc1nc(N)c2c(ccc3c2ccn3Cc2ccc3c(c2)OCO3)n1 CHEMBL532464 IC50 203.0 nM
O=[N+]([O-])c1cccc(Nc2nccc(-c3cnn4ncccc34)n2)c1 CHEMBL526110 IC50 210.0 nM
CC(C)(C)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)CNCC3)c1 CHEMBL4633651 IC50 220.0 nM
COc1cccc(Cn2ccc3c4c(N)nc(N)nc4ccc32)c1 CHEMBL581702 IC50 225.0 nM
C[C@@H]1C[C@@H]([C@H](O)CC2CC(=O)NC(=O)C2)C(=O)[C@@H](C)C1 CHEMBL123292 IC50 228.0 nM
CN(C)Cc1cccc(-c2cc3c(-c4cnn(C)c4)c(Cl)cnc3[nH]2)c1 CHEMBL587029 IC50 230.0 nM
COc1cnccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 CHEMBL3781847 IC50 230.0 nM
COc1ccc(-n2ncc3c(N4CCN(c5ccccc5OC)CC4)ncnc32)cc1 CHEMBL3781625 IC50 230.0 nM
C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](O)[C@H](OC(=O)NCCc3ccc(O)cc3)[C@@]2(C)O1 CHEMBL327672 Kd 240.0 nM
CC1(NC(=O)COc2cccc(-c3nc4c(c(Nc5ccc(-c6cn[nH]c6)cc5)n3)CN(C3CCC3)CC4)c2)CC1 CHEMBL4647401 IC50 242.0 nM
CCCCCCn1c2c(c(=N)c3c1CCC3)CCC2 CHEMBL530291 IC50 251.0 nM
Nc1nc(N)c2c(ccc3c2ccn3Cc2cccc(F)c2)n1 CHEMBL525149 IC50 254.0 nM
CC(C)(C)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)CN(C2CCC2)CC3)c1 CHEMBL4632395 IC50 259.0 nM
C[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)Cc1cccc(O)c1)c1ccccc1 CHEMBL4061928 IC50 267.0 nM
CN1CCN(c2ccc(Nc3nccc(-c4cnn5ncccc45)n3)cc2Cl)CC1 CHEMBL588259 IC50 268.0 nM
Fc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccc2)CC1 CHEMBL3780459 IC50 270.0 nM
CC(C)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COC3)c1 CHEMBL4648466 IC50 289.0 nM
Fc1cccc(N2CCN(c3ncnc4c3cnn4-c3ccccc3)CC2)c1 CHEMBL3781994 IC50 290.0 nM
Cn1ncc2ccc(Nc3nccc(-c4ccc5c(c4)c(N)nn5C)n3)cc21 CHEMBL580914 IC50 294.0 nM
C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](OC(=O)NCCN=C=S)[C@H](OC(C)=O)[C@@]2(C)O1 CHEMBL107985 Kd 300.0 nM
COc1ccccc1N1CCN(c2ccnc3c2cnn3-c2ccccc2)CC1 CHEMBL3780756 IC50 300.0 nM
COc1ccc(C[C@H]2NC[C@H](O)[C@H]2OC(C)=O)cc1 CHEMBL423192 IC50 321.0 nM
CC(C)N1CCc2nc(-c3cccc(OCC(=O)NC(C)(C)C)c3)nc(Nc3ccc(-c4cn[nH]c4)cc3)c2C1 CHEMBL4648473 IC50 326.0 nM
CCC(C)(C)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)CN(C)CC3)c1 CHEMBL4635864 IC50 342.0 nM
Cc1cccc(Nc2nc(N[C@@H]3CCCNC3)nc3cc[nH]c(=O)c23)c1 CHEMBL587120 IC50 358.0 nM
Nc1nc(N)c2c(ccc3c2ccn3Cc2ccccc2)n1 CHEMBL581135 IC50 358.0 nM
CN1CCc2nc(-c3cccc(OCC(=O)NC(C)(C)C)c3)nc(Nc3ccc(-c4cn[nH]c4)cc3)c2C1 CHEMBL4638502 IC50 359.0 nM
COc1ccc(Cn2ncc3c4c(N)nc(N)nc4ccc32)cc1OC CHEMBL587153 IC50 371.0 nM
CCN(Cc1cccc2ccccc12)c1ccc2nc(N)nc(N)c2c1 CHEMBL593290 IC50 382.0 nM
C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](O)[C@H](OC(=O)NCCCCCCNC(=O)CCc3ccc(O)cc3)[C@@]2(C)O1 CHEMBL324659 Kd 400.0 nM
COc1ccccc1N1CCN(c2ncnc3c2cnn3C(C)c2ccccc2)CC1 CHEMBL3780729 IC50 410.0 nM
CCC(CC)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)CNCC3)c1 CHEMBL4637134 IC50 441.0 nM
CCCNC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COC3)c1 CHEMBL4632920 IC50 447.0 nM
O=c1[nH]cnc2nc([C@@H](O)c3ccccc3)[nH]c12 CHEMBL4064730 IC50 450.0 nM
O=C(COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)CNCC3)c1)NC1CCCC1 CHEMBL4635564 IC50 459.0 nM
CCN1CCN(Cc2c(O)ccc3c(=O)c(Oc4cc(C)cc(C)c4)c(C(F)(F)F)oc23)CC1 CHEMBL526210 IC50 464.0 nM
COc1ccc(Nc2ncc(Cl)c(Nc3cccnc3C(N)=O)n2)cc1N1CCN(C)CC1 CHEMBL532472 IC50 470.0 nM
COc1ccccc1N1CCC(c2ncnc3c2cnn3-c2ccccc2)CC1 CHEMBL3781290 IC50 470.0 nM
C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](O)[C@H](OC(=O)NCCN=C=S)[C@@]2(C)O1 CHEMBL110686 Kd 500.0 nM
COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2ccccn2)CC1 CHEMBL3780349 IC50 510.0 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4cccnc4C(N)=O)n3)cc2)CC1 CHEMBL546522 IC50 547.0 nM
CCN1CCc2nc(-c3cccc(OCC(=O)NC(C)(C)C)c3)nc(Nc3ccc(-c4cn[nH]c4)cc3)c2C1 CHEMBL4641999 IC50 552.0 nM
CN1CCc2nc(-c3cccc(OCC(=O)NC4CCCC4)c3)nc(Nc3ccc(-c4cn[nH]c4)cc3)c2C1 CHEMBL4633530 IC50 559.0 nM
O=C(COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COC3)c1)NCC(F)(F)F CHEMBL4635844 IC50 565.0 nM
CCCCCCCCn1c2c(c(=N)c3c1CCC3)CCC2 CHEMBL593052 IC50 580.0 nM
CN1CCN(c2ccc(Nc3nccc(-c4cnn5ncccc45)n3)cc2C(F)(F)F)CC1 CHEMBL468963 IC50 580.0 nM
CCCCCCCn1c2c(c(=N)c3c1CCC3)CCCC2 CHEMBL536166 IC50 604.0 nM
CCCCCCCCn1c2c(c(=N)c3c1CCC3)CCCC2 CHEMBL580918 IC50 612.0 nM
Nc1nc(N)c2c(ccc3c2ccn3Cc2ccccn2)n1 CHEMBL580307 IC50 662.0 nM
O=C(COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COC3)c1)NC1CC1 CHEMBL4649021 IC50 666.0 nM
CN(C)Cc1cccc(-c2ccc(NC(=O)c3ccc4c(=O)n(C5CCCCC5)cnc4c3)cc2)c1 CHEMBL535475 IC50 687.0 nM
CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2c1cc(OC)c(OC)c2Br CHEMBL547077 IC50 704.0 nM
COc1ccccc1N1CCN(c2ncnc3c2cnn3-c2cccnc2)CC1 CHEMBL3781797 IC50 750.0 nM
CN(CCO)Cc1ccc(-c2ccc(NS(=O)(=O)c3cccc4cccnc34)cc2)cc1 CHEMBL532699 IC50 753.0 nM
CN1CCc2nc(-c3cccc(OCC(=O)NC4CCC4)c3)nc(Nc3ccc(-c4cn[nH]c4)cc3)c2C1 CHEMBL4637311 IC50 763.0 nM
N#Cc1ccc(Cn2ccc3c4c(N)nc(N)nc4ccc32)cc1 CHEMBL526243 IC50 777.0 nM
CCC(CC)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)CN(C)CC3)c1 CHEMBL4647586 IC50 789.0 nM
Cc1ccc(-c2nc3cc(NC(=O)c4ccc([N+](=O)[O-])o4)ccc3o2)cc1Cl CHEMBL536115 IC50 794.0 nM
C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](O)[C@H](OC(=O)NCCCCNC(=O)CCc3ccc(O)cc3)[C@@]2(C)O1 CHEMBL111425 Kd 800.0 nM
CCOC(=O)[C@@]12CN(C(=O)OC(C)(C)C)CC=C1N(CCc1ccc(OC)c(OC)c1)C(=O)[C@H]2CC(=O)NCc1cccc2ccccc12 CHEMBL4101090 Ki 800.0 nM
Cc1cc(Nc2ncc(C#N)c(Nc3ccccc3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL528849 IC50 884.0 nM
O=C(COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)COC3)c1)Nc1ccccc1 CHEMBL4649877 IC50 885.0 nM
COc1ccc2nccc([C@@H](O)CN3CCC(NCc4cc5c(F)ccc(F)c5[nH]4)CC3)c2n1 CHEMBL588020 IC50 887.0 nM
O=C(NCCc1cccc(Cl)c1Cl)c1cnc(N2CCN(c3ccncc3)CC2)c(Cl)c1 CHEMBL532650 IC50 914.0 nM
CC(C)NC(=O)COc1cccc(-c2nc3c(c(Nc4ccc(-c5cn[nH]c5)cc4)n2)CN(C2CCC2)CC3)c1 CHEMBL4642809 IC50 914.0 nM
CN(C)c1ccc(C=Cc2ccc3ccccc3n2)c(Cl)c1 CHEMBL536112 IC50 930.0 nM
Cc1ccc(-n2c(C)nc3c(Nc4ccc(-c5ccncc5)cc4)ncnc32)c(C)c1 CHEMBL582042 IC50 953.0 nM
CN1CCc2cc(NC(=O)c3cc4ccccc4s3)cc(-c3ccccc3)c2CC1 CHEMBL587090 IC50 953.0 nM
CCOC(=O)c1cc(=O)c2ccc(OCC#N)cc2o1 CHEMBL581791 IC50 1000.0 nM