O=C(O)C1CCCNC1 CHEMBL277498 IC50 10.1 nM
Cc1ccccc1/C(=C\CCN1CCC[C@@H](C(=O)O)C1)c1ccccc1F CHEMBL1641613 pKi 14.79 nM
Cc1ccsc1C(=CCCN1CCC[C@@H](C(=O)O)C1)c1sccc1C CHEMBL1027 pKi 16.98 nM
O=C(O)[C@@H]1CCCN(CC/C=C(/c2ccccc2F)c2ccccc2Cl)C1 CHEMBL1642396 pKi 18.2 nM
Cc1cc(F)ccc1/C(=C\CCN1CCC[C@@H](C(=O)O)C1)c1ccccc1F CHEMBL1642400 pKi 19.05 nM
Cc1ccccc1/C(=C\CCN1CCC[C@@H](C(=O)O)C1)c1ccccc1 CHEMBL1642378 pKi 20.42 nM
O=C(O)[C@@H]1CCCN(CC/C=C(/c2ccccc2F)c2ccccc2Br)C1 CHEMBL1642397 pKi 21.88 nM
O=C(O)[C@@H]1CCCN(CC/C=C(/c2ccccc2)c2ccccc2Br)C1 CHEMBL1642376 pKi 28.84 nM
CCc1ccccc1/C(=C\CCN1CCC[C@@H](C(=O)O)C1)c1ccccc1 CHEMBL1642379 pKi 29.51 nM
Cc1cc(F)ccc1/C(=C\CCN1CCC[C@@H](C(=O)O)C1)c1ccccc1 CHEMBL1642384 pKi 33.88 nM
CCc1ccccc1/C(=C\CCN1CCC[C@@H](C(=O)O)C1)c1ccccc1F CHEMBL1642395 pKi 38.02 nM
Cc1cc(F)ccc1/C(=C\CCN1CCC[C@@H](C(=O)O)C1)c1ccccc1C(F)(F)F CHEMBL1642401 pKi 38.9 nM
O=C(O)[C@@H]1CCCN(CC/C=C(/c2ccccc2)c2ccccc2Cl)C1 CHEMBL1642375 pKi 40.74 nM
Cc1ccccc1C(=CCCN1CCC[C@@H](C(=O)O)C1)c1ccccc1C CHEMBL1642394 pKi 41.69 nM
O=C(O)[C@@H]1CCCN(CCC=C(c2ccccc2F)c2ccccc2F)C1 CHEMBL1642388 pKi 46.77 nM
Cc1ccsc1C(=CCCN1CCC[C@@H](C(=O)O)C1)c1sccc1C CHEMBL1695 IC50 49.0 nM
O=C(O)[C@@H]1CCCN(CC/C=C(/c2ccccc2F)c2ccccc2OC(F)(F)F)C1 CHEMBL1642398 pKi 52.48 nM
COc1ccccc1/C(=C\CCN1CCC[C@@H](C(=O)O)C1)c1ccccc1F CHEMBL1642399 pKi 53.7 nM
O=C(O)[C@H]1CNC[C@@H](CN/N=C/c2ccc(-c3cccc4ccccc34)o2)C1 CHEMBL4525620 Kd(app) 56.0 nM
COc1ccccc1/C(=C\CCN1CCC[C@@H](C(=O)O)C1)c1ccccc1 CHEMBL1642381 pKi 56.23 nM
O=C(O)[C@H]1CNC[C@@H](CN/N=C/c2ccc(-c3cc(C(F)(F)F)cc(C(F)(F)F)c3)o2)C1 CHEMBL4537310 Kd(app) 57.7 nM
O=C(O)[C@@H]1CCCN(CC/C=C(/c2ccccc2)c2ccccc2OC(F)(F)F)C1 CHEMBL1642382 pKi 58.88 nM
Cc1ccccc1/C(=C\CCN1CCC[C@@H](C(=O)O)C1)c1ccccc1Cl CHEMBL1642391 pKi 61.66 nM
Cc1ccsc1C(=CCCN1CCC[C@@H]1[C@H](O)C(=O)O)c1sccc1C CHEMBL3398501 pKi 66.07 nM
O=C(O)[C@@H]1CCCN(CC/C=C(/c2ccccc2)c2ccccc2F)C1 CHEMBL1642374 pKi 69.18 nM
COc1ccccc1/C(=C/CCN1CCC[C@@H](C(=O)O)C1)c1ccccc1C CHEMBL1642393 pKi 70.79 nM
O=C(O)[C@@H]1CCCN(CCC=C(c2ccccc2)c2ccccc2)C1 CHEMBL77626 pKi 72.44 nM
Cc1ccccc1/C(=C/CCN1CCC[C@@H](C(=O)O)C1)c1ccccc1F CHEMBL1642386 pKi 72.44 nM
Cc1cccc(C)c1/C(=C\CCN1CCC[C@@H](C(=O)O)C1)c1ccccc1 CHEMBL1642385 pKi 77.62 nM
CCc1ccccc1/C(=C/CCN1CCC[C@@H](C(=O)O)C1)c1ccccc1F CHEMBL1642387 pKi 89.13 nM
Cc1ccccc1/C(=C/CCN1CCC[C@@H](C(=O)O)C1)c1ccccc1 CHEMBL1642367 pKi 93.33 nM
O=C(O)[C@@H]1CCCN(CC/C=C(/c2ccccc2)c2ccccc2C(F)(F)F)C1 CHEMBL1642377 pKi 93.33 nM
CCc1ccccc1/C(=C/CCN1CCC[C@@H](C(=O)O)C1)c1ccccc1 CHEMBL1642368 pKi 102.33 nM
O=C(O)C1CCCN(CCC=C(c2ccccc2)c2ccccc2)C1 CHEMBL38686 IC50 130.0 nM
Cc1ccc(C(=CCCN2CCCC(F)(C(=O)O)C2)c2ccc(C)s2)s1 CHEMBL1642402 pKi 138.04 nM
O=C(O)[C@@H]1CCCN(CC/C=C(\c2ccccc2F)c2ccccc2Cl)C1 CHEMBL1642389 pKi 158.49 nM
O=C(O)[C@@H]1CCCN(CC/C=C(\c2ccccc2)c2ccccc2Cl)C1 CHEMBL1642364 pKi 165.96 nM
O=C(O)[C@@H]1CCCN(CC/C=C(\c2ccccc2)c2ccccc2Br)C1 CHEMBL1642365 pKi 199.53 nM
O=C(O)C1=CCCN(CCC=C(c2ccccc2)c2ccccc2)C1 CHEMBL103623 IC50 200.0 nM
O=C(O)[C@@H](O)[C@H]1CCCN1CCC=C(c1ccccc1)c1ccccc1 CHEMBL3398499 pKi 213.8 nM
O=C(O)C1=CCCN(CCOC(c2ccc(C(F)(F)F)cc2)c2ccc(C(F)(F)F)cc2)C1 CHEMBL77287 IC50 260.0 nM
O=C(O)[C@@H]1CCCN(CCOCCN2c3ccccc3Sc3ccccc32)C1 CHEMBL1190271 pIC50 309.03 nM
O=C(O)[C@@H]1CCCN(CC/C=C(/c2ccccc2)c2c(F)cccc2F)C1 CHEMBL1642383 pKi 331.13 nM
O=C(O)[C@@H]1CCCN(CCC=C(c2sccc2COc2ccccc2)c2sccc2COc2ccccc2)C1 CHEMBL556819 IC50 340.0 nM
O=C(O)[C@@H]1CCCN(CC/C=C(\c2ccccc2F)c2ccccc2C(F)(F)F)C1 CHEMBL1642390 pKi 354.81 nM
O=C(O)[C@@H]1CCCN(CC/C=C(\c2ccccc2)c2ccccc2F)C1 CHEMBL1642363 pKi 371.54 nM
COc1ccccc1/C(=C/CCN1CCC[C@@H](C(=O)O)C1)c1ccccc1 CHEMBL1642370 pKi 371.54 nM
Cc1cc(F)ccc1/C(=C/CCN1CCC[C@@H](C(=O)O)C1)c1ccccc1 CHEMBL1642373 pKi 380.19 nM
Cc1ccccc1/C(=C\CCN1CCC[C@@H](C(=O)O)C1)c1ccccc1C(F)(F)F CHEMBL1642392 pKi 380.19 nM
O=C(O)[C@@H]1CCCN(CC/C=C(\c2ccccc2)c2ccccc2OC(F)(F)F)C1 CHEMBL1642371 pKi 645.65 nM
O=C(O)[C@@H]1CCCN(CCOCCN2c3ccccc3C=Cc3ccccc32)C1 CHEMBL1196076 pIC50 645.65 nM
O=C(O)C1CCCCN1CCC=C(c1sccc1COc1ccccc1)c1sccc1COc1ccccc1 CHEMBL559211 IC50 650.0 nM
O=C(O)[C@@H]1CCCN(CC/C=C(\c2ccccc2)c2ccccc2-c2ccccc2)C1 CHEMBL1642369 pKi 676.08 nM
O=C(O)[C@@H]1CCCN(CCC=C(c2sccc2COC2CCCCC2)c2sccc2COC2CCCCC2)C1 CHEMBL536277 IC50 680.0 nM
O=C(O)[C@@H]1CCCN(CC/C=C(\c2ccccc2)c2c(F)cccc2F)C1 CHEMBL1642372 pKi 691.83 nM
O=C(O)C1(F)CCCN(CCC=C(c2ccccc2)c2ccccc2)C1 CHEMBL1642403 pKi 831.76 nM
O=C(O)[C@@H]1CCCN(CCC=C(c2sccc2COCc2ccccc2)c2sccc2COCc2ccccc2)C1 CHEMBL534481 IC50 840.0 nM
O=C(O)C1CCCCN1CCC=C(c1sccc1COC1CCCCC1)c1sccc1COC1CCCCC1 CHEMBL557786 IC50 940.0 nM