COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(I)cc1)N2 CHEMBL353333 Ki 0.12 nM
Cc1csc([C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)n1 CHEMBL1818444 pKi 0.1585 nM
Cc1csc(C23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)n1 CHEMBL1818445 pKi 0.1995 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(Cl)c(Cl)c1)N2C CHEMBL42553 Ki 0.2 nM
CN1C2CCC1[C@@H](/C=C/Cl)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL28394 Ki 0.22 nM
CSCCSCCC(=O)OC[C@@H]1C2CCC(C[C@@H]1c1ccc(F)cc1)N2C CHEMBL422290 IC50 0.227 nM
Cc1ccc([C@H]2C[C@@H]3CC[C@H]([C@H]2C=C(Br)Br)N3C)cc1 CHEMBL495464 IC50 0.23 nM
COC(=O)C1C(c2ccc(Cl)c(Cl)c2)C[C@H]2C[C@@H](O)C1N2C CHEMBL91184 IC50 0.3 nM
CN1[C@H]2CC[C@@H]1[C@@H](C=C(Br)Br)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL494626 IC50 0.32 nM
Fc1ccc(C(OCCN2CCN(CCCc3ccccc3)CC2)c2ccc(F)cc2)cc1 CHEMBL281594 Ki 0.36 nM
CN1[C@H]2CC[C@@H]1[C@@H](C(=O)N1CCCC1)[C@@H](c1ccc(I)cc1)C2 CHEMBL1643896 IC50 0.37 nM
COC(=O)C1C(c2ccc(Cl)c(Cl)c2)CC2CCC1N2C CHEMBL87031 IC50 0.38 nM
COC(=O)[C@H]1[C@@H](c2ccc(Br)cc2)C[C@@H]2CC[C@H]1N2C/C=C/CF CHEMBL1947100 pKi 0.3981 nM
O[C@@H](Cc1ccccc1)CN1CCC(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 CHEMBL380406 Ki 0.4 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(Br)cc1)N2C/C=C/CF CHEMBL1214007 Ki 0.4 nM
Fc1ccc(C(OCCC2CCN(C/C=C/c3ccccc3)CC2)c2ccc(F)cc2)cc1 CHEMBL137718 Ki 0.45 nM
COC(=O)[C@@H]1C2CC[C@H](C[C@@H]1c1ccc(I)cc1)N2C CHEMBL311347 Ki 0.48 nM
COC(=O)C1C2CCC(C[C@@H]1c1ccc(I)cc1)CN2C CHEMBL348552 Ki 0.48 nM
CNCCCN1c2ccccc2CCc2ccccc21 CHEMBL72 Ki 0.49 nM
COC(=O)C1C(c2ccc3ccccc3c2)CC2CCC1N2C CHEMBL87567 IC50 0.49 nM
Fc1ccc(C(OCCC2CCN(C[C@@H]3C[C@H]3c3ccccc3)CC2)c2ccc(F)cc2)cc1 CHEMBL381256 Ki 0.5 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(I)cc1)N2C/C=C/CF CHEMBL1214059 Ki 0.5 nM
COC(=O)[C@H]1[C@@H](c2ccc(I)cc2)C[C@@H]2CC[C@H]1N2C/C=C/CF CHEMBL1944824 pKi 0.5012 nM
COC(=O)[C@H]1C(c2ccc3ccccc3c2)CC2CCC1N2C CHEMBL318138 IC50 0.57 nM
COC(=O)C1C2CC[C@H](C[C@@H]1c1ccc(Cl)c(C)c1)N2C CHEMBL50858 IC50 0.6 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(Cl)cc1)N2C/C=C/CF CHEMBL1214006 Ki 0.6 nM
COC(=O)[C@H]1[C@@H](c2ccc(Cl)cc2)C[C@@H]2CC[C@H]1N2C/C=C/CF CHEMBL1947099 pKi 0.6026 nM
CC(C)(C)CCC1(C(=O)c2cc(F)c3[nH]ccc3c2)CCNC1 CHEMBL1224321 pKi 0.631 nM
COC(=O)C1C2CCC(CC1c1ccc(Cl)c(Cl)c1)N2 CHEMBL169471 IC50 0.66 nM
C[C@@H](CF)OC(=O)C1C(c2ccc(Cl)cc2)CC2CCC1N2C CHEMBL2112916 Ki 0.67 nM
C[C@@H](CF)OC(=O)[C@H]1[C@@H](c2ccc(Cl)cc2)C[C@@H]2CC[C@H]1N2C CHEMBL1944827 pKi 0.6761 nM
COC(=O)C1C2CCC(CC1c1ccc(I)cc1)N2 CHEMBL14613 Ki 0.69 nM
FC(F)(F)c1ccc(Oc2ccc3c(c2)CN2CCC3(c3ccc(Cl)c(Cl)c3)CC2)nn1 CHEMBL3673167 IC50 0.7 nM
Fc1ccc(C(OCCC2CCN(Cc3ccc4ccccc4c3)CC2)c2ccc(F)cc2)cc1 CHEMBL416409 Ki 0.71 nM
Fc1ccc(C(OCCC2CCN(Cc3cc4ccccc4[nH]3)CC2)c2ccc(F)cc2)cc1 CHEMBL538405 Ki 0.73 nM
O[C@@H](Cc1ccccc1)CN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 CHEMBL27646 Ki 0.75 nM
CCc1cc([C@H]2[C@@H](c3ccc(C)cc3)C[C@@H]3CC[C@H]2N3C)on1 CHEMBL1812741 IC50 0.75 nM
COC(=O)[C@@H]1C(c2ccc(Cl)c(Cl)c2)C[C@H]2C[C@@H](O)C1N2C CHEMBL606929 IC50 0.76 nM
CNC1CC(c2ccc(Cl)c(Cl)c2)c2ccccc21 CHEMBL296602 pKi 0.7943 nM
Cc1noc([C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)n1 CHEMBL1818447 pKi 0.7943 nM
O[C@H](CCN1CCC(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1ccccc1 CHEMBL383682 Ki 0.8 nM
CN1[C@H]2CC[C@@H]1[C@@H](C#Cc1ccccc1)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL494814 IC50 0.8 nM
Cc1ccc([C@H]2C[C@@H]3CC[C@H]([C@H]2C#Cc2ccccc2)N3C)cc1 CHEMBL494807 IC50 0.8 nM
CCOC(=O)C1C(c2ccc(Cl)c(Cl)c2)CC2C[C@@H](O)C1N2C CHEMBL86590 IC50 0.81 nM
COC(=O)[C@H]1[C@@H](c2ccc(Cl)c(C)c2)C[C@H]2CC[C@H]1N2C CHEMBL457865 IC50 0.82 nM
Cc1ccc([C@H]2C[C@@H]3CC[C@H]([C@H]2C(=O)OC(C)C)N3C)cc1 CHEMBL1812739 IC50 0.83 nM
COC(=O)[C@H]1[C@@H](c2ccc(C)cc2)C[C@@H]2CC[C@H]1N2C/C(I)=C/C(F)(F)F CHEMBL1947088 Ki 0.87 nM
CC(C)OC(=O)C1C2CCC(C[C@@H]1c1ccc(Cl)cc1)CN2C CHEMBL345689 Ki 0.9 nM
O[C@@H](CCN1CCC(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1ccccc1 CHEMBL205025 Ki 0.9 nM
C[C@H](Cc1ccccc1)CN1CCC(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 CHEMBL444540 Ki 0.9 nM
Cc1ccc([C@H]2CC3CCC([C@H]2c2ccc(F)cc2)N3C)cc1 CHEMBL225235 IC50 0.9 nM
CN1[C@H]2CC[C@@H]1[C@@H](C#Cc1ccc([N+](=O)[O-])cc1)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL522699 IC50 0.9 nM
C[C@@H](CCNCCCC(N)=O)CC1(c2ccc(Cl)c(Cl)c2)CCC1 CHEMBL3704754 Ki 0.91 nM
CCCC(c1ccc(Cl)c(Cl)c1)C1CCCCN1 CHEMBL219649 Ki 0.97 nM
Fc1ccc(C(OCCC2CCN(C/C=C/c3ccco3)CC2)c2ccc(F)cc2)cc1 CHEMBL136057 Ki 0.99 nM
CC(C)CC(c1ccc(Cl)c(Cl)c1)C1CCCCN1 CHEMBL218999 Ki 1.0 nM
Fc1ccc(Oc2cc(F)c(F)cc2C2CCNCC2)cc1 CHEMBL574427 Ki 1.0 nM
CN1C2CCC1[C@@H](C(=O)OCc1cn(CCCCCCOC(=O)[C@H]3C4CCC(C[C@@H]3c3ccc(Cl)cc3)N4C)nn1)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL596001 Ki 1.0 nM
CC(C)CCC1(C(=O)c2cc(F)c3[nH]ccc3c2)CCNC1 CHEMBL1224320 pKi 1.0 nM
Cc1cccc2nc(C(=O)C3(CCC(C)(C)C)CCNC3)ccc12 CHEMBL1224240 pKi 1.0 nM
CN(C)CC1(c2ccc(Cl)c(Cl)c2)CCCCC1 CHEMBL1683874 IC50 1.0 nM
CCN(C)CC1(c2ccc(Cl)c(Cl)c2)CCCCC1 CHEMBL1683875 IC50 1.0 nM
CN(C)CC1(c2cccc3ccccc23)CCCCC1 CHEMBL1683899 IC50 1.0 nM
Cc1cnc([C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)o1 CHEMBL1818443 pKi 1.0 nM
Fc1ccc(C(OCCC2CCN(Cc3cc4ccccc4o3)CC2)c2ccc(F)cc2)cc1 CHEMBL136154 Ki 1.01 nM
OC1(c2ccc(Cl)cc2)c2cc(Cl)c(Cl)cc2C2=NCCN21 CHEMBL132955 Ki 1.05 nM
COC(=O)C1C2CC[C@H](C[C@@H]1c1ccc(I)cc1)N2C CHEMBL300226 IC50 1.08 nM
COC(=O)C1C(c2ccc(I)cc2)CC2CCC1N2C CHEMBL14391 IC50 1.08 nM
OC1(c2ccc3c(c2)OCO3)c2ccccc2C2=NCCCN21 CHEMBL544370 IC50 1.09 nM
Fc1ccc(C(OCCC2CCN(CCCc3ccccc3)CC2)c2ccc(F)cc2)cc1 CHEMBL77867 Ki 1.1 nM
COC(=O)C1C(c2ccc(Cl)cc2)CC2CCC1N2C CHEMBL306208 Ki 1.1 nM
Fc1ccc(C(OCCC2CCN(CC3=Cc4ccccc4CC3)CC2)c2ccc(F)cc2)cc1 CHEMBL205005 Ki 1.1 nM
COC(=O)C1C2CC[C@H](C[C@@H]1c1ccc(Cl)cc1)N2C CHEMBL610897 IC50 1.1 nM
COC(=O)[C@H]1[C@@H](c2ccc(Cl)c(Cl)c2)C[C@@H]2CC[C@H]1N2C CHEMBL1945780 IC50 1.1 nM
COC(=O)C1=C(c2ccc(Cl)c(Cl)c2)CC2CCC1N2C CHEMBL88915 IC50 1.16 nM
CCOCCCCN[C@H](CC(C)C)C1(c2ccc(Cl)c(Cl)c2)CCC1 CHEMBL3897671 Ki 1.16 nM
COC(=O)C1C(c2ccc(Cl)c(Cl)c2)CC2C[C@@H](O)C1N2C CHEMBL330228 IC50 1.19 nM
C=C[C@@H]1C2CCC(C[C@@H]1c1ccc(Cl)cc1)N2C CHEMBL281288 IC50 1.2 nM
CN(Cc1cccc(F)c1)[C@H]1C2C3CC4C5C3CC2C5C41 CHEMBL1643901 Ki 1.2 nM
COC(=O)[C@H]1[C@@H](c2ccc(Cl)cc2)C[C@@H]2CC[C@H]1N2C/C=C/[125I] CHEMBL2048526 Kd 1.2 nM
COc1ccc([C@@H]2C3CCC(C[C@@H]2c2ccc(C)cc2)N3C)cc1 CHEMBL224062 IC50 1.23 nM
C=CCC(OC)[C@]12CNCC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1173087 pKi 1.259 nM
CC(C)(C)CCC1(C(=O)c2cc3ccccc3s2)CCNC1 CHEMBL1224237 pKi 1.259 nM
Cc1cc(C(F)(F)F)n(C[C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)n1 CHEMBL1818461 pKi 1.259 nM
COC(=O)C1C(c2ccc3ccccc3c2)CC2C[C@@H](O)C1N2C CHEMBL86654 IC50 1.26 nM
Fc1ccc(C(OCCC2CCN(C/C=C/c3cccs3)CC2)c2ccc(F)cc2)cc1 CHEMBL343534 Ki 1.3 nM
C[C@@H](CCN1CCC(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1ccccc1 CHEMBL383071 Ki 1.3 nM
Fc1ccc(C(OCCN2CCN(CCCc3ccccc3)CC2)c2ccc(F)cc2)cc1 CHEMBL542933 Ki 1.3 nM
O=C(OCCF)[C@H]1[C@@H](c2ccc(I)cc2)C[C@@H]2CC[C@H]1N2C/C=C/I CHEMBL3105243 Ki 1.33 nM
Cc1ccc([C@H]2CC3CCC([C@H]2c2ccc(C)cc2)N3C)cc1 CHEMBL2096877 IC50 1.35 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(Cl)c(Cl)c1)N2 CHEMBL47210 IC50 1.4 nM
Fc1ccc(C(OCCC2CCN(C[C@H]3C[C@@H]3c3ccccc3)CC2)c2ccc(F)cc2)cc1 CHEMBL206128 Ki 1.4 nM
O[C@@H](Cc1ccccc1)CN1CCC(CCOC(c2ccccc2)c2ccccc2)CC1 CHEMBL204586 Ki 1.4 nM
O[C@H](CCc1ccccc1)CN1CCC(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 CHEMBL202860 Ki 1.4 nM
COC(=O)C(c1ccc(Cl)c(Cl)c1)C1CCCCN1 CHEMBL220195 Ki 1.4 nM
CN1[C@H]2CC[C@@H]1[C@H](C=C(Br)Br)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL494624 IC50 1.4 nM
COC(=O)C1C2CCC(CC1c1ccc(Cl)cc1)N2 CHEMBL81525 IC50 1.43 nM
COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1 CHEMBL814 Ki 1.46 nM
Cc1cc([C@H]2[C@@H](c3ccc(Cl)c(C)c3)C[C@@H]3CC[C@H]2N3C)on1 CHEMBL1812747 IC50 1.5 nM
CC(CCNCCCC(N)=O)CC1(c2ccc(Cl)c(Cl)c2)CCC1 CHEMBL3704753 Ki 1.5 nM
CC(C)CC(NCCCC(N)=O)C1(c2ccc(Cl)c(Cl)c2)CCC1 CHEMBL3946788 Ki 1.5 nM
COC[C@H]1CN[C@H]2CC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL4228464 pKi 1.514 nM
COc1ccc(-c2cc([C@@H]3C4CCC(C[C@@H]3c3ccc(Cl)cc3)N4C)on2)cc1 CHEMBL469887 IC50 1.57 nM
FC(F)(F)c1ccnn1C[C@@]12CNCC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1818456 pKi 1.585 nM
O[C@@H](CCc1ccccc1)CN1CCC(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 CHEMBL383464 Ki 1.6 nM
C#Cc1ccc([C@@H]2CN3CCC[C@@H]3c3ccccc32)cc1 CHEMBL286312 Ki 1.6 nM
Fc1ccc(C(OCCC2CCN(Cc3cc4ccccc4s3)CC2)c2ccc(F)cc2)cc1 CHEMBL137020 Ki 1.61 nM
OC1(c2ccc(Cl)cc2)c2ccccc2C2=NCCCN21 CHEMBL130477 Ki 1.7 nM
O[C@H](Cc1ccccc1)CN1CCC(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 CHEMBL204530 Ki 1.7 nM
COC(=O)[C@@H]1C2CCC(C[C@H]1c1ccc(Br)cc1)N2C CHEMBL224819 IC50 1.7 nM
COC(=O)[C@@H]1C2CC[C@H](C[C@@H]1c1ccc(C)cc1)N2C CHEMBL312037 IC50 1.7 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(Br)cc1)N2C CHEMBL218082 IC50 1.7 nM
COC(=O)[C@H]1[C@@H](c2ccc(I)cc2)C[C@@H]2CC[C@H]1N2C/C=C/I CHEMBL1945251 Ki 1.72 nM
O[C@H](CCN1CCC(CCOC(c2ccccc2)c2ccccc2)CC1)c1ccccc1 CHEMBL204060 Ki 1.8 nM
COC(=O)[C@H](c1ccc(Cl)c(Cl)c1)[C@H]1CCCCN1 CHEMBL1179011 Ki 1.8 nM
CC1(C)NCC(c2ccc(Cl)c(Cl)c2)c2ccc(-c3cnccn3)cc21 CHEMBL3703728 IC50 1.8 nM
CN1C2CCC1[C@@H](c1cc(-c3ccc(F)cc3)no1)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL511466 IC50 1.86 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(/C=C/I)cc1)N2 CHEMBL173427 Ki 1.88 nM
COC(=O)[C@H]1[C@@H](c2ccc(C)cc2)C[C@@H]2CC[C@H]1N2CC#CCF CHEMBL562115 IC50 1.93 nM
Cc1ccc([C@H]2CC3CCC([C@H]2c2ccccc2)N3C)cc1 CHEMBL224771 IC50 1.96 nM
COC[C@@]12CNCC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1173532 pIC50 1.995 nM
CC(C)(C)CCC1(C(=O)c2cc(Cl)c(Cl)s2)CCNC1 CHEMBL1224241 pKi 1.995 nM
Cc1cc([C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)no1 CHEMBL1818446 pKi 1.995 nM
Cc1cc(C(F)(F)F)nn1C[C@@]12CNCC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1818460 pKi 1.995 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(Cl)c(Cl)c1)S2 CHEMBL227757 IC50 2.0 nM
CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1ccccc1C#N CHEMBL382741 IC50 2.0 nM
Clc1ccc(C2(CNC3CC3)CCCCC2)cc1Cl CHEMBL1683873 IC50 2.0 nM
Clc1ccc(C2(CN3CCCC3)CCCCC2)cc1Cl CHEMBL1683877 IC50 2.0 nM
Clc1ccc(C2(CN3CCOCC3)CCCCC2)cc1Cl CHEMBL1683879 IC50 2.0 nM
COC(=O)[C@H]1[C@@H](c2ccc(Cl)c(C)c2)C[C@@H]2CC[C@H]1N2C CHEMBL1812745 IC50 2.0 nM
N[C@H]1CC[C@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 CHEMBL4227980 IC50 2.0 nM
OC1(c2ccc(Cl)cc2)c2ccc3ccccc3c2C2=NCCCN21 CHEMBL334577 Ki 2.01 nM
O[C@@H](CCN1CCC(CCOC(c2ccccc2)c2ccccc2)CC1)c1ccccc1 CHEMBL383745 Ki 2.1 nM
CC1(C)NCC(c2ccc(Cl)c(Cl)c2)c2ccc(-c3ccc4ncnn4c3)cc21 CHEMBL3703748 IC50 2.1 nM
C[C@H](CCN1CCC(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1ccccc1 CHEMBL424682 Ki 2.2 nM
CN1[C@H]2CC[C@@H]1[C@@H](C#Cc1ccc(N)cc1)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL496913 IC50 2.2 nM
c1ccc2sc(C3(N4CCCCC4)CCCCC3)cc2c1 CHEMBL279556 Ki 2.2 nM
COC(=O)[C@@H]1[C@H]2CC[C@H](C[C@H]1c1ccc(I)cc1)N2 CHEMBL398370 Ki 2.25 nM
C#Cc1ccc([C@@H]2C[C@H]3CC[C@@H](N3)[C@H]2C(=O)OC)cc1 CHEMBL394158 Ki 2.26 nM
CCCCC(c1ccc(Cl)c(Cl)c1)C1CCCCN1 CHEMBL374634 Ki 2.3 nM
O[C@@H](Cc1ccccc1)CN1CCN(CCOC(c2ccccc2)c2ccccc2)CC1 CHEMBL28149 Ki 2.3 nM
COC(=O)[C@H]1[C@@H](c2ccc(Cl)c(C)c2)C[C@@H]2CC[C@H]1N2 CHEMBL1812746 IC50 2.3 nM
COC(=O)C1C2CCC(CC1c1ccc(Cl)c(Cl)c1)O2 CHEMBL316342 IC50 2.34 nM
CCOCCNC(CC(C)C)C1(c2ccc(Cl)c(Cl)c2)CCC1 CHEMBL3974108 Ki 2.38 nM
COCCCCN[C@H](CC(C)C)C1(c2ccc(Cl)c(Cl)c2)CCC1 CHEMBL3965642 Ki 2.39 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(C)cc1)N2C/C=C/CF CHEMBL1214060 IC50 2.4 nM
CC1(C)NCC(c2ccc(Cl)c(Cl)c2)c2ccc(-c3ccc(N)nn3)cc21 CHEMBL3703732 IC50 2.4 nM
Fc1ccc(C(OCCN2CCN(CCCc3ccccc3)CC2)c2ccc(F)cc2)cc1 CHEMBL543876 Ki 2.42 nM
COc1ccc([C@H]2C[C@H]3CC[C@H]([C@H]2C(=O)OCCc2ccc(N)c(I)c2)N3C)cc1 CHEMBL459332 IC50 2.5 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(-c3ccsc3)cc1)N2C CHEMBL595677 Ki 2.5 nM
Clc1ccc([C@]23CNC[C@H]2[C@@H]3COC2CCCC2)cc1Cl CHEMBL596987 pKi 2.512 nM
CC(C)(C)CCC1(C(=O)c2cc3ccccc3[nH]2)CCNC1 CHEMBL1224238 pKi 2.512 nM
CCCC1(C(=O)c2ccc3[nH]ccc3c2)CCCN1 CHEMBL1224164 pKi 2.512 nM
CC[C@@H]1C2CCC(C[C@@H]1c1ccc(Cl)cc1)N2C CHEMBL27336 IC50 2.6 nM
COC(=O)[C@H]1[C@@H](c2ccc(F)cc2)C[C@H]2CC[C@H]1N2C CHEMBL2079586 IC50 2.62 nM
CN(CCC[18F])C[C@H]1[C@@H](c2ccc(Cl)cc2)C[C@@H]2CC[C@H]1N2C CHEMBL2048520 Ki 2.64 nM
OC1(c2ccc(Cl)cc2)c2ccccc2C2=N[C@H]3CCCC[C@@H]3N21 CHEMBL337020 IC50 2.7 nM
Fc1ccc(C(OCCN2CCN(C[C@@H](F)Cc3ccccc3)CC2)c2ccc(F)cc2)cc1 CHEMBL468211 Ki 2.7 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(Cl)cc1)N2C CHEMBL608703 Ki 2.7 nM
CC(C)CC(c1cccc(Cl)c1)C1CCCCN1 CHEMBL219335 IC50 2.8 nM
OC1(c2ccc3ccccc3c2)c2ccc3ccccc3c2C2=NCCN21 CHEMBL340281 Ki 2.83 nM
COc1cccc2c1C1=NCCN1C2(O)c1ccc(Cl)cc1 CHEMBL336940 Ki 2.9 nM
COC(=O)C1=C(c2ccc3ccccc3c2)CC2CCC1N2C CHEMBL84680 IC50 2.9 nM
COC(=O)[C@@H]1C2CCC(C[C@H]1c1ccc(I)cc1)N2C CHEMBL375889 IC50 2.9 nM
COC(=O)/C=C1/CN2C3CCC2C1C(c1ccc(Br)cc1)C3 CHEMBL383873 Ki 2.94 nM
CCC[C@@H]1CN(C)CC[C@@H]1c1ccc(Cl)cc1 CHEMBL109097 IC50 3.0 nM
O[C@H](CCN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1ccccc1 CHEMBL26477 Ki 3.0 nM
CN(C)CC1(c2ccc3ccccc3c2)CCCCC1 CHEMBL1683902 IC50 3.0 nM
COC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@H]1c1ccc(Cl)c(C)c1)N2C CHEMBL1812749 IC50 3.0 nM
CN1CC=CC[C@H](c2ccc(Cl)c(Cl)c2)C1 CHEMBL2321996 Ki 3.0 nM
COC(=O)C1C(c2ccc(Cl)c(Cl)c2)CC2[C@@H](O)CC1N2C CHEMBL421167 IC50 3.02 nM
COC(=O)C1C(c2ccc(Cl)c(Cl)c2)CC2C[C@H](O)C1N2C CHEMBL89476 IC50 3.04 nM
COC(=O)C1C(c2ccc(/C=C\Br)cc2)CC2CCC1N2C CHEMBL14305 Ki 3.1 nM
COC(=O)[C@@H]1C2CCC(C[C@H]1c1ccc(Cl)cc1)N2C CHEMBL375888 IC50 3.1 nM
CN1Cc2cc(N3CCOCC3)ccc2[C@@H](c2ccc3sccc3c2)C1 CHEMBL3323181 IC50 3.1 nM
NC(=O)c1cc2cc(N3CCNCC3Cc3ccccc3)ccc2[nH]1 CHEMBL1170017 pKi 3.162 nM
Clc1ccc([C@]23CCNC[C@@]2(COCC2CC2)C3)cc1Cl CHEMBL1173595 pKi 3.162 nM
CC(C)(C)CCC1(C(=O)c2ccc(N)c(Cl)c2)CCNC1 CHEMBL1224317 pKi 3.162 nM
CC(C)CC1(C(=O)c2ccc(N)c(Cl)c2)CCCN1 CHEMBL1224090 pKi 3.162 nM
CC(C)OCC1(C(=O)c2ccc(N)c(Cl)c2)CCCN1 CHEMBL1224091 pKi 3.162 nM
CC(C)(C)CCC1(C(=O)c2ccc3[nH]ncc3c2)CCCN1 CHEMBL1224094 pKi 3.162 nM
Cc1ccnn1CC12CNCC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1818452 pKi 3.162 nM
Cc1cc(C)n(CC23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)n1 CHEMBL1818455 pKi 3.162 nM
Clc1cccc(O[C@H](c2ccccc2)[C@@H]2CCNC2)c1Cl CHEMBL2337603 pKi 3.162 nM
C[C@H](CF)OC(=O)C1C(c2ccc(Cl)cc2)CC2CCC1N2C CHEMBL2112915 Ki 3.2 nM
C[C@H](CF)OC(=O)[C@H]1[C@@H](c2ccc(Cl)cc2)C[C@@H]2CC[C@H]1N2C CHEMBL1944828 pKi 3.236 nM
COC(=O)[C@H]1[C@@H](c2ccc(Cl)c(Cl)c2)C[C@@H]2CC[C@H]1O2 CHEMBL5271116 IC50 3.27 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(Cl)c(Cl)c1)O2 CHEMBL390929 IC50 3.3 nM
COc1ccc([C@H]2C[C@H]3CC[C@H]([C@H]2C(=O)OCCc2ccc(N)c(Br)c2)N3C)cc1 CHEMBL514424 IC50 3.3 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(/C=C\I)cc1)N2 CHEMBL174088 Ki 3.47 nM
COC(=O)C1C2CCC(CC1c1ccc(/C=C\I)cc1)N2 CHEMBL428706 Ki 3.5 nM
CC(C)CCC(c1ccc(Cl)cc1)C1CCCCN1 CHEMBL373710 Ki 3.6 nM
C#C[C@H]1[C@@H](c2ccc(Cl)cc2)C[C@@H]2CC[C@H]1N2C CHEMBL449047 IC50 3.6 nM
Cc1ccc([C@H]2C[C@@H]3CC[C@H]([C@@H]2C=C(Br)Br)N3C)cc1 CHEMBL524188 IC50 3.6 nM
c1ccc(CCCN2CCN(CCOC(c3ccccc3)c3ccccc3)CC2)cc1 CHEMBL26320 Ki 3.7 nM
CN(CC[18F])C[C@H]1[C@@H](c2ccc(Cl)cc2)C[C@@H]2CC[C@H]1N2C CHEMBL2048519 Ki 3.79 nM
C[C@@H](Cc1ccccc1)CN1CCC(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 CHEMBL202644 Ki 3.8 nM
CN1C2CCC1C1COC(=O)CCCCCC(=O)Nc3ccc(cc3)C1C2 CHEMBL214209 IC50 3.8 nM
CN1Cc2ccccc2C(c2ccc3sccc3c2)C1 CHEMBL3323095 Ki 3.8 nM
CN1Cc2ccccc2C(c2ccc3[nH]ccc3c2)C1 CHEMBL3323101 Ki 3.8 nM
C[C@@H]1CN(CC[S+]([O-])C(c2ccc(F)cc2)c2ccc(F)cc2)C[C@H](C)N1CC(O)Cc1ccccc1 CHEMBL4639814 Ki 3.83 nM
COC(=O)C1C2CCC(CC1c1ccc(/C=C\Br)cc1)N2 CHEMBL14531 Ki 3.9 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(I)cc1)N2C CHEMBL610766 Ki 3.9 nM
CN1C2CCC1[C@@H](C(=O)OCc1cn(CCCCCCCOC(=O)[C@H]3C4CCC(C[C@@H]3c3ccc(Cl)cc3)N4C)nn1)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL595190 Ki 3.9 nM
COc1ccc(-c2cc([C@H]3[C@@H](c4ccc(Cl)cc4)C[C@@H]4CC[C@H]3N4C)on2)cc1 CHEMBL1812743 IC50 3.9 nM
COc1ccc(-c2cc([C@@H]3C4CCC(C[C@@H]3c3ccc(C)cc3)N4C)on2)cc1 CHEMBL469888 IC50 3.93 nM
Clc1ccc([C@]23CNC[C@H]2[C@@H]3COC2CCC2)cc1Cl CHEMBL611063 pKi 3.981 nM
CC(=O)[C@@]12CNCC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1173754 pKi 3.981 nM
CCOC[C@@]12CNCC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1173533 pKi 3.981 nM
CCCCC1(C(=O)c2cc(F)c3[nH]ccc3c2)CCNC1 CHEMBL1224492 pKi 3.981 nM
CC(C)(C)CCC1(C(=O)c2ccc(Cl)c(Cl)c2)CCNC1 CHEMBL1224400 pKi 3.981 nM
CC(C)(C)CCC1(C(=O)c2ccc3ccccc3n2)CCNC1 CHEMBL1224239 pKi 3.981 nM
CCCC1(C(=O)c2cc(F)c3[nH]ccc3c2)CCCN1 CHEMBL1224165 pKi 3.981 nM
Clc1ccc([C@]23CCNCC2(Cn2cc4ccccc4n2)C3)cc1Cl CHEMBL1818547 pKi 3.981 nM
COC(=O)[C@H]1[C@@H](c2ccc(I)cc2)C[C@H]2CC[C@@H]1N2C CHEMBL242338 Ki 4.0 nM
CC(O)(CCN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1ccccc1 CHEMBL512636 Ki 4.0 nM
CCNCC1(c2ccc(Cl)c(Cl)c2)CCCCC1 CHEMBL1683872 IC50 4.0 nM
COC(=O)[C@H](c1ccc(N=[N+]=[N-])c(I)c1)[C@H]1CCCCN1 CHEMBL2062931 Ki 4.0 nM
Cc1ccc(-c2cc([C@@H]3C4CCC(C[C@@H]3c3ccc(Cl)cc3)N4C)on2)cc1 CHEMBL470690 IC50 4.09 nM
OC1(c2ccc3ccccc3c2)c2ccccc2C2=NCCN21 CHEMBL132676 IC50 4.1 nM
CN1C2CCC1[C@@H](CNc1cccc(F)n1)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL1914699 Ki 4.1 nM
OCC[C@]1(c2ccc(Cl)c(Cl)c2)CCCCNC1 CHEMBL2326695 Ki 4.2 nM
O[C@@H](CCN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1ccccc1 CHEMBL26478 Ki 4.4 nM
CN(C)Cc1ccc2c(c1)CN(C)CC2c1ccc2sccc2c1 CHEMBL3323179 Ki 4.4 nM
COC(=O)C1=C(c2ccc(Cl)c(Cl)c2)CC2CCC1S2 CHEMBL186242 IC50 4.5 nM
COC(=O)[C@H](c1cccc(I)c1)[C@H]1CCCCN1 CHEMBL1641691 Ki 4.5 nM
CN1Cc2ccccc2C(c2ccc3ccsc3c2)C1 CHEMBL3323096 IC50 4.5 nM
CN1Cc2ccccc2C(c2ccc3occc3c2)C1 CHEMBL3323089 Ki 4.5 nM
CN1Cc2ccccc2C(c2cccc3ccoc23)C1 CHEMBL3323094 Ki 4.5 nM
CN1Cc2ccccc2C(c2cccc3sccc23)C1 CHEMBL3323099 Ki 4.5 nM
COC(=O)/C=C1/CN2C3CCC2C1C(c1ccc(Cl)cc1)C3 CHEMBL215236 Ki 4.54 nM
CN(CCOCC[18F])C[C@H]1[C@@H](c2ccc(Cl)cc2)C[C@@H]2CC[C@H]1N2C CHEMBL2048521 Ki 4.63 nM
Cc1ccc([C@H]2C[C@@H]3CC[C@H]([C@H]2C(=O)OC2CCC2)N3C)cc1 CHEMBL1812740 IC50 4.8 nM
CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 CHEMBL4128926 IC50 4.9 nM
CN1C2CCC1C(C(=O)OCCCF)C(c1ccc(Br)cc1)C2 CHEMBL365649 Ki 5.0 nM
O=C(OCCCF)C1C2CCC(CC1c1ccc(Br)cc1)N2 CHEMBL184807 Ki 5.0 nM
CN1C2CCC1C(C(=O)OCCF)C(c1ccc(Br)cc1)C2 CHEMBL185608 Ki 5.0 nM
O=C(OCCF)C1C2CCC(CC1c1ccc(Br)cc1)N2 CHEMBL186119 Ki 5.0 nM
O=C(OCCF)C1C2CCC(CC1c1ccc(I)cc1)N2 CHEMBL186306 Ki 5.0 nM
O=C(CCCCC1SCC2NC(=O)NC21)NCCCCCCCCCCC(=O)Nc1ccc(CCCN2CCN(CCOC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 CHEMBL379107 IC50 5.0 nM
CCCC(C(=O)c1ccc(N)cc1)N1CCCC1 CHEMBL555491 Ki 5.0 nM
CN1CC=CCC(c2ccc(Cl)c(Cl)c2)C1 CHEMBL2321995 Ki 5.0 nM
O=C(CCN1[C@@H]2CC[C@H]1C[C@@H](OC(c1ccc(F)cc1)c1ccc(F)cc1)C2)Nc1ccccc1 CHEMBL3085020 Log 1/Ki 5.012 nM
CCC(C)OCC[C@]1(c2ccc(Cl)c(Cl)c2)[C@@H]2CNC[C@@H]21 CHEMBL596806 pKi 5.012 nM
CC(C)OC[C@@H]1[C@H]2CNC[C@]21c1ccc(Cl)c(Cl)c1 CHEMBL605209 pKi 5.012 nM
CCOC[C@H]1[C@@H]2CNC[C@@]21c1ccc(Cl)c(Cl)c1 CHEMBL608151 pIC50 5.012 nM
CCOC(=O)[C@@]12CNCC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1173751 pKi 5.012 nM
CC(C)CC1(C(=O)c2cc(F)c3[nH]ccc3c2)CCNC1 CHEMBL1224490 pKi 5.012 nM
COC[C@H]1CN[C@@H]2CC[C@@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL4227100 pKi 5.012 nM
Oc1ccc(-c2ccc3c(c2)CN2CCC3(c3ccc(Cl)c(Cl)c3)CC2)nn1 CHEMBL3673163 IC50 5.1 nM
C#Cc1ccc(C2CN3CCCC3c3ccccc32)cc1 CHEMBL330666 Ki 5.2 nM
CN1C2CCC1C(C(=O)Oc1ccccc1)C(c1ccc(Cl)cc1)C2 CHEMBL14144 Ki 5.25 nM
Fc1ccc(C(OCCC2CCN(CC#Cc3ccccc3)CC2)c2ccc(F)cc2)cc1 CHEMBL136249 Ki 5.3 nM
CCCOCCCN[C@H](CC(C)C)C1(c2ccc(Cl)c(Cl)c2)CCC1 CHEMBL3903154 Ki 5.45 nM
CN1C2CCC1[C@@H](C(=O)OCCCCCn1ccnn1)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL606809 Ki 5.5 nM
COC(=O)C1C2CCC(CC1c1ccc(C=C(Br)Br)cc1)N2 CHEMBL14257 Ki 5.6 nM
CN1C2CCC1[C@@H](CNc1cccc(Br)n1)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL1914696 Ki 5.6 nM
CN1Cc2cc(-c3ccc(N)nn3)ccc2[C@H](c2ccc3ccccc3c2)C1 CHEMBL2364614 IC50 5.7 nM
COC[C@@H]1CN[C@H]2CC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL4227688 pKi 5.754 nM
CN1Cc2cc(N3CCOCC3)ccc2C(c2cc3ccccc3s2)C1 CHEMBL3323184 IC50 5.8 nM
NC(=O)c1ccc(-c2cc3c(cc2F)C(c2ccc(Cl)c(Cl)c2)CNC3)cc1 CHEMBL3703739 IC50 5.8 nM
Cc1ccc(C(=O)C(CC(C)C)N2CCCC2)cc1 CHEMBL202409 IC50 5.9 nM
Cc1ccc([C@H]2CC3CCC([C@H]2c2cc(Cc4ccc(F)cc4)no2)N3C)cc1 CHEMBL486041 IC50 5.9 nM
COc1ccc(-c2ccc3c(c2)CN2CCC3(c3ccc(Cl)c(Cl)c3)CC2)nn1 CHEMBL3673162 IC50 5.9 nM
COc1ccc2c(c1)C(O)(c1ccc(Cl)cc1)N1CCN=C21 CHEMBL132082 Ki 6.0 nM
Clc1ccc(C2c3ccccc3C3=NCCN32)cc1 CHEMBL336613 IC50 6.0 nM
CN(C)C[C@H]1C2CCC(C2)[C@@H]1c1ccc2cc(O)ccc2c1 CHEMBL419385 Ki 6.0 nM
COc1ccc([C@H]2C[C@H]3CC[C@H]([C@H]2C(=O)OC2CC2)N3C)cc1 CHEMBL457635 IC50 6.0 nM
COc1ccc([C@H]2C[C@H]3CC[C@H]([C@H]2C(=O)OCCc2ccc(NC(C)=O)cc2)N3C)cc1 CHEMBL457655 IC50 6.0 nM
Clc1cccc(OC(c2cccnc2)[C@@H]2CCCNC2)c1Cl CHEMBL549825 IC50 6.0 nM
Fc1ccc(Oc2cccc(F)c2C2CCNCC2)cc1 CHEMBL574231 Ki 6.0 nM
CCC[C@@H]1NC(C)(C)CO[C@@]1(O)c1cccc(Cl)c1 CHEMBL1173597 IC50 6.0 nM
OCC[C@]1(c2cc3ccccc3o2)CCCNC1 CHEMBL2321993 Ki 6.0 nM
Clc1ccc([C@H]2CC=CCNC2)cc1Cl CHEMBL2321999 Ki 6.0 nM
Clc1ccc(C2CC=CCNC2)cc1Cl CHEMBL2321998 Ki 6.0 nM
CN1[C@H]2CC[C@@H]1[C@@H](c1ncc(-c3ccc([N+](=O)[O-])cc3)s1)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL227232 Ki 6.1 nM
COc1ccc(Cc2cc([C@@H]3C4CCC(C[C@@H]3c3ccc(Cl)cc3)N4C)on2)cc1 CHEMBL487874 IC50 6.1 nM
N[C@@H](Cc1ccccc1)CN1CCC(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 CHEMBL381842 Ki 6.3 nM
COC(=O)[C@H](c1ccc(N)cc1)[C@H]1CCCCN1 CHEMBL1253709 Ki 6.3 nM
Clc1ccc([C@@]2(CCOC3CCC3)[C@@H]3CNC[C@@H]32)cc1Cl CHEMBL611367 pKi 6.31 nM
CC(C)OCC[C@]1(c2ccc(Cl)c(Cl)c2)[C@@H]2CNC[C@@H]21 CHEMBL596805 pKi 6.31 nM
Clc1ccc([C@@]2(COC3CCC3)[C@@H]3CNC[C@@H]32)cc1Cl CHEMBL590472 pKi 6.31 nM
c1ccc(CC2CNCCN2c2ccc3[nH]ccc3c2)cc1 CHEMBL1171391 pKi 6.31 nM
CCCC1(C(=O)c2ccc(Cl)c(Cl)c2)CCCN1 CHEMBL1224024 pKi 6.31 nM
CCCC1(C(=O)c2ccc(N)c(Cl)c2)CCCN1 CHEMBL1224089 pKi 6.31 nM
CC(C)CC1(C(=O)c2ccc3[nH]ncc3c2)CCCN1 CHEMBL1224093 pKi 6.31 nM
Cc1csc(C[C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)n1 CHEMBL1818448 pKi 6.31 nM
Cc1cc(C)n(C[C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)n1 CHEMBL1818454 pKi 6.31 nM
CC(C)(C)c1ccn(C[C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)n1 CHEMBL1818462 pKi 6.31 nM
COC(=O)[C@H]1[C@@H](c2ccc(I)cc2)C[C@@H]2CC[C@H]1N2C CHEMBL215376 Ki 6.34 nM
COC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@H]1c1ccc(C)c(F)c1)N2 CHEMBL1812750 IC50 6.4 nM
COC(=O)[C@@H]1[C@H]2CC[C@H](C[C@H]1c1ccc(C)c(F)c1)N2 CHEMBL391864 Ki 6.42 nM
CN1C2CCC1[C@@H](c1cc(-c3ccc(Cl)cc3)no1)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL512878 IC50 6.42 nM
Cc1ccc([C@H]2CC3CCC([C@H]2c2cc(-c4ccc(F)cc4)no2)N3C)cc1 CHEMBL470903 IC50 6.45 nM
O=C(NCCN1C2CCC1CC(OC(c1ccc(F)cc1)c1ccc(F)cc1)C2)c1ccccc1 CHEMBL115253 Log 1/Ki 6.457 nM
O=C(Cc1ccccc1)CN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 CHEMBL511950 Ki 6.5 nM
COC(=O)[C@H]1[C@@H](c2ccc(OC)cc2)C[C@H]2CC[C@H]1N2C CHEMBL512202 IC50 6.5 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(OC)cc1)N2C CHEMBL574081 IC50 6.5 nM
[O-][S+](CCN1CCN(CC(O)Cc2ccccc2)CC1)C(c1ccc(F)cc1)c1ccc(F)cc1 CHEMBL3918282 Ki 6.5 nM
O=C(NCCCCC(c1ccc(F)cc1)c1ccc(F)cc1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL4744589 Ki 6.5 nM
CC(C)CC(c1ccc(Cl)c(Cl)c1)C1CCCCN1C CHEMBL387117 Ki 6.6 nM
CN1C2CCC1[C@@H](C(=O)Nc1ccc(CCNC(=O)[C@H]3C4CCC(C[C@@H]3c3ccc(Cl)cc3)N4C)cc1)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL611960 Ki 6.6 nM
CN1C2CCC1C(C(=O)NCCCCCCCCNC(=O)C1C(c3ccc(Cl)cc3)CC3CCC1N3C)C(c1ccc(Cl)cc1)C2 CHEMBL307314 Ki 6.7 nM
COC(=O)C1=C(c2ccc(I)cc2)CC2CCC1S2 CHEMBL364146 IC50 6.7 nM
COC(=O)C1C(c2ccc(C=C(Br)Br)cc2)CC2CCC1N2C CHEMBL14924 Ki 6.73 nM
O[C@H](Cc1ccccc1)CN1CCC(CCOC(c2ccccc2)c2ccccc2)CC1 CHEMBL382783 Ki 6.9 nM
Cc1ccc(Cc2cc([C@@H]3C4CCC(C[C@@H]3c3ccc(C)cc3)N4C)on2)cc1 CHEMBL487873 IC50 6.9 nM
CN1Cc2cc(O)ccc2C(c2ccc3sccc3c2)C1 CHEMBL3323175 IC50 6.9 nM
COC(=O)C1C2CCC(CC1c1ccc(I)cc1)O2 CHEMBL313664 IC50 7.0 nM
CC(O)(CCN1CCN(CCOC(c2ccccc2)c2ccccc2)CC1)c1ccccc1 CHEMBL469165 Ki 7.0 nM
COc1ccc([C@H]2C[C@H]3CC[C@H]([C@H]2C(=O)OCCc2ccc(N)cc2)N3C)cc1 CHEMBL458080 IC50 7.0 nM
Cc1cc([C@@H]2C3CCC(C[C@@H]2c2ccc(F)cc2)S3)on1 CHEMBL1643663 IC50 7.0 nM
CN1Cc2c(N)cccc2[C@H](c2ccccc2)C1 CHEMBL51697 Ki 7.0 nM
COC(=O)C1=C(c2ccc(Cl)c(Cl)c2)CC2CCC1C2 CHEMBL322923 IC50 7.1 nM
Nc1ccc(-c2ccc3c(c2)CNCC3c2ccc(Cl)c(Cl)c2)nn1 CHEMBL3703744 IC50 7.1 nM
CN(C)C[C@@H]1C2CCC(CC2)[C@@H]1c1ccc(Cl)c(Cl)c1 CHEMBL322067 Ki 7.2 nM
Cc1cc([C@@H]2C3CCC(C[C@@H]2c2ccc(Cl)cc2)S3)on1 CHEMBL1643664 IC50 7.2 nM
CN(C)C[C@H]1C2CCC(CC2)[C@H]1c1ccc(Cl)c(Cl)c1 CHEMBL173861 Ki 7.2 nM
CCC(=O)OCCNC(CC(C)C)C1(c2ccc(Cl)c(Cl)c2)CCC1 CHEMBL3704748 Ki 7.2 nM
Cc1cc2nc([C@H]3[C@@H](c4ccc(Cl)cc4)C[C@@H]4CC[C@H]3N4C)[nH]c2cc1C CHEMBL1812744 IC50 7.3 nM
COC(=O)C1=C(c2ccc(Cl)c(Cl)c2)C[C@H]2C[C@@H](O)C1N2C CHEMBL606930 IC50 7.37 nM
CCCC(c1ccc(Cl)cc1)C1CCCCN1 CHEMBL218847 IC50 7.4 nM
CN1Cc2ccccc2C(c2ccc3ccoc3c2)C1 CHEMBL3323090 IC50 7.5 nM
COC(=O)C1C(c2ccc3ccccc3c2)CC2[C@@H](O)CC1N2C CHEMBL315172 IC50 7.7 nM
CN1[C@H]2CC[C@@H]1[C@@H](c1ncc(-c3cccc([N+](=O)[O-])c3)s1)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL388760 Ki 7.7 nM
CCCCC(c1ccc(Cl)cc1)C1CCCCN1 CHEMBL218849 Ki 7.8 nM
CN1C2CCC1[C@@H](CNc1ccnc(Br)c1)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL1914698 Ki 7.9 nM
COC(=O)C1C(c2cccc(Br)c2)CC2CCC1N2C CHEMBL171106 IC50 7.93 nM
CCC(C)OC[C@]1(c2ccc(Cl)c(Cl)c2)[C@@H]2CNC[C@@H]21 CHEMBL598228 pKi 7.943 nM
CC(C)OC[C@H]1[C@@H]2CNC[C@@]21c1ccc(Cl)c(Cl)c1 CHEMBL602235 pKi 7.943 nM
O=C(c1ccc2[nH]ccc2c1)C1(Cc2ccccc2)CCNC1 CHEMBL1224562 pKi 7.943 nM
O=C(c1cc(F)c2[nH]ccc2c1)C1(Cc2ccccc2)CCNC1 CHEMBL1224563 pKi 7.943 nM
CC(C)(C)CCC1(C(=O)c2ccc3[nH]ncc3c2)CCNC1 CHEMBL1224319 pKi 7.943 nM
Cc1cc(C)n(C[C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)c1 CHEMBL1818468 pKi 7.943 nM
Fc1ccc(F)c(O[C@H](c2ccccc2)[C@@H]2CCNC2)c1Cl CHEMBL2338049 pKi 7.943 nM
Fc1cc(Cl)cc(Cl)c1O[C@@H](c1ccccc1)[C@H]1CCNC1 CHEMBL2338047 pKi 7.943 nM
COC(=O)C1=C(c2ccc3ccccc3c2)CC2CCC1S2 CHEMBL365092 IC50 8.0 nM
CCCCCCC(=O)OC[C@H]1[C@@H](c2ccc(Cl)c(Cl)c2)CC2CC[C@H]1N2C CHEMBL255140 IC50 8.0 nM
Fc1ccc(C(OCCN2CCN(CCc3ccccc3)CC2)c2ccc(F)cc2)cc1 CHEMBL26649 Ki 8.0 nM
CN1[C@H]2CC[C@@H]1[C@@H](c1cn(CCN3CCCCC3)nn1)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL496911 IC50 8.0 nM
CCCC(C(=O)c1ccc(C)cc1)N1CCCC1 CHEMBL201960 Ki 8.0 nM
CN[C@@H]1CCN(c2ccc(Cl)c(Cl)c2)c2ccccc21 CHEMBL1643513 IC50 8.0 nM
COC(=O)[C@H]1[C@@H](c2ccc(Cl)cc2)C[C@@H]2CC[C@H]1N2CCF CHEMBL2206307 Ki 8.0 nM
CN1CCCCC(c2ccc(Cl)c(Cl)c2)C1 CHEMBL2326691 Ki 8.0 nM
Clc1ccc([C@@H]2CC=CCNC2)cc1Cl CHEMBL2322000 Ki 8.0 nM
CCOC[C@H]1[C@@H](c2ccc(Cl)c(Cl)c2)C[C@@H]2CC[C@H]1N2C CHEMBL4224951 IC50 8.0 nM
CCN[C@@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 CHEMBL147983 Ki 8.1 nM
Fc1ccc(C(OC2CC3CCC(C2)N3CCNCc2ccccc2)c2ccc(F)cc2)cc1 CHEMBL324518 Log 1/Ki 8.128 nM
O=C1NCC(c2ccc(Cl)c(Cl)c2)C1c1ccccc1Cl CHEMBL2430688 IC50 8.14 nM
OC1(c2ccc(Cl)cc2)c2ccccc2C2=N[C@@H]3CCCC[C@@H]3N21 CHEMBL424627 IC50 8.4 nM
C=C1CN2C3CCC2C1C(c1ccc(I)cc1)C3 CHEMBL380383 Ki 8.48 nM
CN1Cc2cc(-c3cccnn3)ccc2C(c2ccc3sccc3c2)C1 CHEMBL3663917 Ki 8.5 nM
CC(C)CC(c1ccc(Cl)cc1)C1CCCCN1 CHEMBL220247 IC50 8.6 nM
COc1ccc(-c2cnc([C@H]3[C@@H](c4ccc(Cl)cc4)C[C@@H]4CC[C@H]3N4C)s2)cc1 CHEMBL227233 Ki 8.6 nM
CN1C2CCC1[C@@H](c1cc(Cc3ccc(F)cc3)no1)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL488423 IC50 8.6 nM
CN(C)[C@@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 CHEMBL356750 Ki 8.7 nM
Cc1ccc([C@H]2CC3CCC([C@H]2c2cc(-c4ccc(Cl)cc4)no2)N3C)cc1 CHEMBL471696 IC50 8.74 nM
COC(=O)C1C(c2cccc(-c3ccccc3)c2)CC2CCC1N2C CHEMBL294733 Ki 8.83 nM
COC(=O)C1C2CCC(CC1c1ccc(Br)cc1)O2 CHEMBL88792 IC50 9.0 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(SC)cc1)N2C CHEMBL579056 IC50 9.0 nM
CN(C)CC1(c2ccc(Cl)c(Cl)c2)CCCC1 CHEMBL1683882 IC50 9.0 nM
CNC(CC(C)C)C1(c2ccc(Cl)c(Cl)c2)CCCCC1 CHEMBL1684046 IC50 9.0 nM
COC(=O)[C@@H]1C2CCC(C[C@H]1c1cc3ccccc3s1)O2 CHEMBL2012111 IC50 9.0 nM
COCCN1CC=CC[C@H](c2ccc(Cl)c(Cl)c2)C1 CHEMBL2326694 Ki 9.0 nM
COc1ccc2c(c1)CN(C)CC2c1ccc2sccc2c1 CHEMBL3323174 IC50 9.0 nM
Fc1ccc(C23CCN(CC2)Cc2cc(Oc4ccc(C(F)(F)F)nn4)ccc23)cc1Cl CHEMBL3673169 IC50 9.0 nM
COC(=O)C1=C(c2ccc(Br)cc2)CC2CCC1S2 CHEMBL187695 IC50 9.1 nM
COC(=O)[C@H](c1ccc(N)c(I)c1)[C@H]1CCCCN1 CHEMBL2062932 Ki 9.1 nM
CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC)nc(C#Cc4ccc(Br)s4)nc31)[C@H](O)[C@@H]2O CHEMBL3407785 EC50 9.1 nM
CN1C2CCC1[C@@H]([C@@H](O)C(F)(F)F)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL27586 IC50 9.2 nM
Nc1cnc(-c2ccc3c(c2)CN2CCC3(c3ccc(Cl)c(Cl)c3)CC2)cn1 CHEMBL3673164 IC50 9.2 nM
OCC[C@]1(c2ccc(Cl)c(Cl)c2)CCCNC1 CHEMBL2321991 Ki 9.3 nM
Clc1ccc(C(CC2CCCC2)C2CCCCN2)cc1 CHEMBL219653 Ki 9.4 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(F)cc1)N2C/C=C/CF CHEMBL1214005 Ki 9.5 nM
COC(=O)[C@H]1[C@@H](c2ccc(F)cc2)C[C@@H]2CC[C@H]1N2C/C=C/CF CHEMBL1947098 pKi 9.55 nM
COC(=O)[C@H]1C2CCC(C2)C[C@@H]1c1ccc(Cl)c(Cl)c1 CHEMBL2111614 IC50 9.6 nM
COc1ccc(Cc2cc([C@@H]3C4CCC(C[C@@H]3c3ccc(C)cc3)N4C)on2)cc1 CHEMBL487875 IC50 9.6 nM
Cc1ccc(C2CC3CCC(C2c2cc(-c4ccc(Cl)cc4)no2)N3C)cc1 CHEMBL328415 Ki 9.7 nM