CNCC[C@@H](Oc1cc(Cl)ccc1Cl)c1ccccc1 CHEMBL1762471 IC50 0.0 nM
CSc1ccc([C@H]2CN3CCC[C@H]3c3ccccc32)cc1 CHEMBL361259 Ki 0.009 nM
CN(C)Cc1ccccc1Sc1ccc(I)cc1N CHEMBL23034 Ki 0.01 nM
CN(C)Cc1ccccc1Sc1ccc([123I])cc1N CHEMBL2314218 Ki 0.013 nM
CN(C)Cc1cc(OCCF)ccc1Sc1ccc(Cl)cc1N CHEMBL239079 Ki 0.03 nM
CN(C)Cc1cc(I)ccc1Sc1ccccc1CO CHEMBL2314217 Ki 0.03 nM
COC(=O)C1C2CCC(CC1c1ccc(/C=C\I)cc1)N2 CHEMBL428706 Ki 0.04 nM
COC(=O)C1C2CCC(CC1c1ccc(/C=C\Br)cc1)N2 CHEMBL14531 Ki 0.04 nM
Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 CHEMBL490 Ki 0.04 nM
CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21 CHEMBL415 Ki 0.047 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(/C=C\I)cc1)N2 CHEMBL174088 Ki 0.05 nM
CN(C)Cc1cc(OCCF)ccc1Sc1ccc(Br)cc1N CHEMBL239297 Ki 0.05 nM
CN(C)[C@@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 CHEMBL356750 Ki 0.06 nM
CC(C)CN(Cc1ccc(C(F)(F)F)cc1)C1CCNCC1 CHEMBL206580 Ki 0.07 nM
CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 CHEMBL809 Ki 0.075 nM
Cc1csc(C[C@H]2[C@@H]3CNC[C@@]32c2ccc(Cl)c(Cl)c2)n1 CHEMBL597000 pKi 0.07943 nM
COC[C@@H]1[C@H]2CNC[C@]21c1ccc2ccccc2c1 CHEMBL598215 pKi 0.07943 nM
COC(=O)C1C(c2ccc(/C=C\Br)cc2)CC2CCC1N2C CHEMBL14305 Ki 0.08 nM
COC(=O)C1C2CCC(CC1c1ccc(C=C(Br)Br)cc1)N2 CHEMBL14257 Ki 0.08 nM
O=C(OCCF)C1C2CCC(CC1c1ccc(/C=C\I)cc1)N2 CHEMBL230000 Ki 0.08 nM
[3H]c1cc2c(cc1OC[C@@H]1CNCC[C@H]1c1ccc(F)cc1)OCO2 CHEMBL1628650 Ki 0.08 nM
O=C(OCC[18F])C1C2CCC(CC1c1ccc(/C=C\I)cc1)N2 CHEMBL395998 Ki 0.08 nM
O=C(OCCF)[C@H]1[C@@H](c2ccc(/C=C\I)cc2)C[C@H]2CC[C@H]1N2 CHEMBL2314215 Ki 0.08 nM
CN(C)Cc1ccccc1Sc1ccc(I)cc1CO CHEMBL114275 Ki 0.09 nM
C=C1CN2C3CCC2C1C(c1ccc(I)cc1)C3 CHEMBL380383 Ki 0.09 nM
CN(C)Cc1ccccc1Sc1ccc([123I])cc1CO CHEMBL2314219 Ki 0.097 nM
NC(=O)c1ccc2c(c1)CCOC2CCN1CC=C(c2c[nH]c3cc(F)ccc23)CC1 CHEMBL83617 Ki 0.1 nM
CN(C)Cc1cc(OCCF)ccc1Sc1ccc(F)cc1N CHEMBL238868 Ki 0.1 nM
Cc1csc(C[C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)n1 CHEMBL1818448 pKi 0.1 nM
COC(=O)C1C(c2ccc(/C=C\I)cc2)CC2CCC1N2C CHEMBL275212 Ki 0.11 nM
CN(C)Cc1ccccc1Oc1ccc(I)cc1CO CHEMBL183470 Ki 0.12 nM
CC(C)OC[C@@H]1[C@H]2CNC[C@]21c1ccc(Cl)c(Cl)c1 CHEMBL605209 pKi 0.1259 nM
C=CCC(OC)[C@]12CNCC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1173087 pKi 0.1259 nM
COC[C@@]12CNCC[C@]1(c1ccc3ccccc3c1)C2 CHEMBL1172744 pKi 0.1259 nM
CN(C)C[C@H]1CCC[C@@H]1c1c[nH]c2ccc(C#N)cc12 CHEMBL552167 IC50 0.13 nM
CN(C)Cc1cc(OCCCF)ccc1Sc1ccc(Br)cc1N CHEMBL239302 Ki 0.15 nM
O=C1COc2ccc(CCN3CCN(c4cccc5nc(-c6ccccc6)ccc45)CC3)cc2N1 CHEMBL484059 pKi 0.1585 nM
COC[C@H]1[C@@H]2CNC[C@@]21c1ccc2ccccc2c1 CHEMBL611379 pKi 0.1585 nM
CCOC[C@H]1[C@@H]2CNC[C@@]21c1ccc(Cl)c(Cl)c1 CHEMBL608151 pKi 0.1585 nM
C=C(C)c1ccc([C@H]2CC3CCC(N3)[C@H]2C(=O)CC)cc1 CHEMBL173344 IC50 0.16 nM
C#CCOc1ccc(C(=O)c2ccc(C(=O)NCc3ccc4c(c3)CO[C@@]4(CCCN(C)C)c3ccc(F)cc3)cc2)cc1 CHEMBL4281744 Ki 0.16 nM
O=[N+]([O-])c1ccc2nc(N3CCNCC3)ccc2c1 CHEMBL41140 Ki 0.17 nM
CN(C)Cc1ccccc1Oc1ccc(I)cc1N CHEMBL186962 Ki 0.171 nM
CN(C)C[C@H]1C[C@@H]1c1c[nH]c2ccc(C#N)cc12 CHEMBL196468 Ki 0.18 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(SC)cc1)N2 CHEMBL574544 Ki 0.19 nM
Clc1ccc([C@@]2(CCOC3CCC3)[C@@H]3CNC[C@@H]32)cc1Cl CHEMBL611367 pKi 0.1995 nM
CC(C)OC[C@H]1[C@@H]2CNC[C@@]21c1ccc(Cl)c(Cl)c1 CHEMBL602235 pKi 0.1995 nM
Cc1cccc2nc(C(=O)C3(CCC(C)(C)C)CCNC3)ccc12 CHEMBL1224240 pKi 0.1995 nM
CNC1CC(c2ccc(Cl)c(Cl)c2)c2ccccc21 CHEMBL296602 pKi 0.1995 nM
Cc1cc(C)n(CC23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)n1 CHEMBL1818455 pKi 0.1995 nM
Clc1ccc([C@]23CCNCC2(Cn2cc4ccccc4n2)C3)cc1Cl CHEMBL1818547 pKi 0.1995 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1cccc(/C=C/I)c1)N2 CHEMBL216736 Ki 0.2 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1cccc(/C=C/Br)c1)N2 CHEMBL385173 Ki 0.2 nM
CN(C)Cc1cc(OCCCO)ccc1Sc1ccc(Br)cc1N CHEMBL397889 Ki 0.21 nM
COc1ccc(O[C@@H](CC(C)C)[C@H]2CCNC2)c(C)n1 CHEMBL2386163 Ki 0.21 nM
CN(C)[C@@H]1CC[C@H](c2c[nH]c3ccc(C#N)cc23)C1 CHEMBL1275709 IC50 0.22 nM
COc1ccc(O[C@H](CC(C)C)[C@H]2CCNC2)c(C)n1 CHEMBL2386164 Ki 0.23 nM
Cc1cc2c(OC[C@@H](O)CN3CC[C@@H](c4cc5cc(F)ccc5s4)C[C@@H]3C)cccc2[nH]1 CHEMBL129238 Ki 0.24 nM
CNCC[C@H](Oc1cccc2ccccc12)c1cccs1 CHEMBL1175 Ki 0.24 nM
Cc1ccc(Sc2ccccc2CN(C)C)c(N)c1 CHEMBL22183 Ki 0.25 nM
CN(C)Cc1cc(OCCF)ccc1Sc1ccccc1N CHEMBL238867 Ki 0.25 nM
C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O CHEMBL196514 Log Ki 0.2512 nM
N#Cc1cccc(CN(c2ccc3[nH]ccc3c2)C2CCNCC2)c1 CHEMBL570317 pKi 0.2512 nM
CCC(C)OC[C@]1(c2ccc(Cl)c(Cl)c2)[C@@H]2CNC[C@@H]21 CHEMBL598228 pKi 0.2512 nM
COCC[C@H]1[C@]2(C)CNC[C@]12c1ccc(Cl)c(Cl)c1 CHEMBL2021580 pKi 0.2512 nM
Clc1ccc([C@]23CNC[C@H]2[C@@H]3COC2CCCC2)cc1Cl CHEMBL596987 pKi 0.2512 nM
CCCOC[C@@H]1[C@H]2CNC[C@]21c1ccc(Cl)c(Cl)c1 CHEMBL598825 pKi 0.2512 nM
Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)C(C)(C)C3)cccc2n1 CHEMBL1289618 pKi 0.2512 nM
Cc1ccn(CC23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)n1 CHEMBL1818451 pKi 0.2512 nM
CC(C)(C)c1ccn(C[C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)n1 CHEMBL1818462 pKi 0.2512 nM
Clc1ccc([C@]23CCNCC2(Cn2ncc4ccccc42)C3)cc1Cl CHEMBL1818441 pKi 0.2512 nM
CC(C)CN(Cc1cccc(C(F)(F)F)c1)C1CCNCC1 CHEMBL381373 Ki 0.26 nM
O=C(OCCCF)C1C2CCC(CC1c1cccc(/C=C\I)c1)N2 CHEMBL462410 Ki 0.26 nM
O=C1CCc2ccc(CC3CC4CCC(C3)N4C[C@@H]3COc4c(ccc5c4CC(=O)N5)O3)cc2N1 CHEMBL1088000 Ki 0.26 nM
CN(C)Cc1ccccc1Sc1ccc(Cl)cc1N CHEMBL432394 Ki 0.27 nM
COc1cccc2sc([C@@H]3CCN(C[C@H](O)COc4cccc5[nH]ccc45)[C@@H](C)C3)cc12 CHEMBL76747 Ki 0.27 nM
COCCOc1cc(CC2CCN(CCc3ccc4occc(=O)c4c3)CC2)ccc1Br CHEMBL3705037 Ki 0.27 nM
C#Cc1ccc([C@@H]2CN3CCC[C@@H]3c3ccccc32)cc1 CHEMBL286312 Ki 0.27 nM
CNCCC(Oc1ccc(C(F)(F)F)cc1)c1ccccc1 CHEMBL41 Ki 0.271 nM
CC(C)CN(Cc1ccc(C#N)cc1)C1CCNCC1 CHEMBL382001 Ki 0.28 nM
C=C1CN2C3CCC2C1C(c1ccc(Br)cc1)C3 CHEMBL212452 Ki 0.28 nM
CN(C)Cc1cc(Br)ccc1Sc1ccc(CO)cc1N CHEMBL253184 Ki 0.29 nM
Cc1cc2c(OC[C@H](O)CN3CC[C@@H](c4ccc5sccc5c4)C[C@@H]3C)cccc2[nH]1 CHEMBL314163 Ki 0.3 nM
CC(C)CN(Cc1ccc(F)cc1C(F)(F)F)C1CCNCC1 CHEMBL441358 Ki 0.3 nM
CCCCN(Cc1ccc2ccccc2c1)[C@H]1CCNC1 CHEMBL471029 IC50 0.3 nM
C[C@H]1C[C@H](c2cc3ccc(F)cc3s2)CCN1C[C@H](O)COc1cccc2[nH]ccc12 CHEMBL309396 Ki 0.31 nM
CN(C)Cc1cc(I)ccc1Sc1ccc(CO)cc1N CHEMBL253387 Ki 0.31 nM
Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)CC3)cc(F)cc2n1 CHEMBL469589 pKi 0.3162 nM
CCC(C)OCC[C@]1(c2ccc(Cl)c(Cl)c2)[C@@H]2CNC[C@@H]21 CHEMBL596806 pKi 0.3162 nM
CC(C)OCC[C@]1(c2ccc(Cl)c(Cl)c2)[C@@H]2CNC[C@@H]21 CHEMBL596805 pKi 0.3162 nM
COCC[C@]1(c2ccc(Cl)c(Cl)c2)[C@@H]2CNC[C@@H]21 CHEMBL602323 pKi 0.3162 nM
Clc1ccc([C@]23CNC[C@H]2[C@@H]3COC2CCC2)cc1Cl CHEMBL611063 pKi 0.3162 nM
Clc1ccc([C@@]23CNC[C@@H]2[C@H]3COCC2CC2)cc1Cl CHEMBL610795 pKi 0.3162 nM
Clc1ccc([C@@H]2CCNC[C@@]23CCCOC3)cc1Cl CHEMBL1173607 pKi 0.3162 nM
Clc1ccc(C2CCNCC23CCOCC3)cc1Cl CHEMBL4224830 pKi 0.3162 nM
C=Cc1ccc([C@H]2CC3CCC(N3)[C@H]2C(=O)CC)cc1 CHEMBL367408 IC50 0.32 nM
N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ncc(-c5ccc(Cl)cc5)cn4)CC3)c2c1 CHEMBL5420565 IC50 0.32 nM
CN(C)Cc1ccccc1Sc1ccc(C(F)(F)F)cc1N CHEMBL104673 Ki 0.33 nM
CN(C)[C@@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 CHEMBL1788140 Ki 0.33 nM
O=C(OCCF)C1C2CCC(CC1c1cccc(/C=C\Br)c1)N2 CHEMBL525952 Ki 0.33 nM
O=C(OCCCF)C1C2CCC(CC1c1cccc(/C=C\Br)c1)N2 CHEMBL462585 Ki 0.33 nM
COc1cccc2ccc([C@@H]3CCN(C[C@H](O)COc4cccc5[nH]c(C)cc45)[C@@H](C)C3)cc12 CHEMBL2112353 Ki 0.34 nM
CN(C)C1CC=C(c2c[nH]c3ccc(C#N)cc23)CC1 CHEMBL390432 IC50 0.34 nM
CN(C)Cc1ccccc1Oc1ccc(Cl)c(Cl)c1 CHEMBL443922 IC50 0.35 nM
N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ncc(-c5cccc(C(N)=O)c5)cn4)CC3)c2c1 CHEMBL5431204 IC50 0.35 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(I)cc1)N2 CHEMBL353333 IC50 0.36 nM
COC(=O)C1C2CCC(CC1c1ccc(I)cc1)N2 CHEMBL14613 Ki 0.36 nM
COC(=O)[C@@H]1C2CC[C@H](C[C@@H]1c1ccc(I)cc1)N2C CHEMBL311347 Ki 0.38 nM
CN(C)[C@H]1CC[C@@H](c2c[nH]c3ccc(C#N)cc23)C1 CHEMBL1275730 IC50 0.38 nM
Cc1ccc(CN(CC(C)C)C2CCNCC2)c(C)c1 CHEMBL207374 Ki 0.39 nM
Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)[C@@H](C)C3)cccc2n1 CHEMBL495703 pKi 0.3981 nM
Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)CC3)cccc2n1 CHEMBL469375 pKi 0.3981 nM
Clc1ccc([C@@]2(COC3CCC3)[C@@H]3CNC[C@@H]32)cc1Cl CHEMBL590472 pKi 0.3981 nM
CSC[C@H]1[C@@H]2CNC[C@@]21c1ccc(Cl)c(Cl)c1 CHEMBL599241 pKi 0.3981 nM
Clc1ccc([C@]23CCNC[C@@]2(COCC2CC2)C3)cc1Cl CHEMBL1173595 pKi 0.3981 nM
CC(C)CC1(C(=O)c2cc(F)c3[nH]ccc3c2)CCNC1 CHEMBL1224490 pKi 0.3981 nM
CC(C)CCC1(C(=O)c2cc(F)c3[nH]ccc3c2)CCNC1 CHEMBL1224320 pKi 0.3981 nM
CC(C)CC1(C(=O)c2ccc(N)c(Cl)c2)CCCN1 CHEMBL1224090 pKi 0.3981 nM
Cc1csc(C23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)n1 CHEMBL1818445 pKi 0.3981 nM
Cc1cc(C)n(C[C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)n1 CHEMBL1818454 pKi 0.3981 nM
Clc1ccc([C@]23CCNC[C@@]2(Cn2cccc2)C3)cc1Cl CHEMBL1818463 pKi 0.3981 nM
Cc1cc2c(OC[C@@H](O)CN3CC[C@@H](c4ccc5ccccc5c4)C[C@@H]3C)cccc2[nH]1 CHEMBL2112350 Ki 0.4 nM
N#CCCCN(Cc1ccc(F)cc1C(F)(F)F)C1CCNCC1 CHEMBL206153 Ki 0.4 nM
N#CCCN(Cc1ccc(F)cc1C(F)(F)F)C1CCNCC1 CHEMBL206152 Ki 0.4 nM
Fc1ccc(CN(CC2CC2)C2CCNCC2)c(C(F)(F)F)c1 CHEMBL207067 Ki 0.4 nM
CN(C)[C@H]1CC=C(c2c[nH]c3ccc(C#N)cc23)CC1 CHEMBL234706 IC50 0.4 nM
N#Cc1cc2cc(C3(Cc4ccccc4)CCNC3)ccc2[nH]1 CHEMBL457930 Ki 0.4 nM
O=c1[nH]c2cccc(OCC3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1 CHEMBL566396 Ki 0.4 nM
N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc5oc(C(N)=O)cc5c4)CC3)c2c1 CHEMBL439849 IC50 0.4 nM
COCCOc1cc(CC2CCN(CCc3ccc4c(c3)C(=O)CCO4)CC2)ccc1I CHEMBL4229131 Ki 0.41 nM
CN1CCc2ccccc2C1CCc1c[nH]c2ccc(C#N)cc12 CHEMBL609908 IC50 0.42 nM
O=C(OCCF)C1C2CCC(CC1c1cccc(/C=C\I)c1)N2 CHEMBL462431 Ki 0.43 nM
Cc1cccc2sc([C@@H]3CCN(C[C@H](O)COc4cccc5[nH]ccc45)[C@@H](C)C3)cc12 CHEMBL311964 Ki 0.44 nM
Fc1cc2c(c(OCCNCCCc3c[nH]c4ccc(F)cc34)c1)OCCC2 CHEMBL124069 Ki 0.47 nM
N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc5oc(C(N)=O)cc5c4)CC3)c2c1 CHEMBL1615374 Ki 0.4705 nM
CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 CHEMBL549 Ki 0.479 nM
CC(C)CN(Cc1cccc(C(F)(F)F)c1Cl)C1CCNCC1 CHEMBL208533 Ki 0.48 nM
CC(C)CN(Cc1cccc(C#N)c1)C1CCNCC1 CHEMBL425589 Ki 0.48 nM
CN(C)C1CCC(c2c[nH]c3ccc(C#N)cc23)C1 CHEMBL1276165 IC50 0.48 nM
CCc1ccc(Sc2ccccc2CN(C)C)c(N)c1 CHEMBL189367 Ki 0.49 nM
c1ccc2c(c1)NC[C@@H]1C2=NO[C@H]1CN1CCN(Cc2ccc3ccccc3c2)CC1 CHEMBL2112984 Ki 0.5 nM
Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cccc2n1 CHEMBL469376 pKi 0.5012 nM
CCOCC[C@]1(c2ccc(Cl)c(Cl)c2)[C@@H]2CNC[C@@H]21 CHEMBL609023 pKi 0.5012 nM
CCOC[C@]1(c2ccc(Cl)c(Cl)c2)[C@@H]2CCC[C@@H]21 CHEMBL2021582 pKi 0.5012 nM
CCCOC[C@H]1[C@@H]2CNC[C@@]21c1ccc(Cl)c(Cl)c1 CHEMBL599845 pKi 0.5012 nM
CC(C)(C)CCC1(C(=O)c2cc(F)c3[nH]ccc3c2)CCNC1 CHEMBL1224321 pKi 0.5012 nM
CCCC1(C(=O)c2ccc(Cl)c(Cl)c2)CCCN1 CHEMBL1224024 pKi 0.5012 nM
Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)[C@H](C)C3)cc(F)cc2n1 CHEMBL1289394 pKi 0.5012 nM
Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4ccc(=O)n5C)[C@@H](C)C3)cccc2n1 CHEMBL1289509 pKi 0.5012 nM
Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)[C@@H](C)C3)cc(F)cc2n1 CHEMBL1289510 pKi 0.5012 nM
Cc1csc([C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)n1 CHEMBL1818444 pKi 0.5012 nM
Cc1ccn(CC23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)c1 CHEMBL1818466 pKi 0.5012 nM
Fc1cc(Cl)cc(Cl)c1O[C@@H](c1ccccc1)[C@H]1CCNC1 CHEMBL2338047 pIC50 0.5012 nM
C[C@H]1C[C@H](c2cc3ccccc3s2)CCN1C[C@H](O)COc1cccc2[nH]ccc12 CHEMBL311701 Ki 0.51 nM
CN(C)Cc1ccccc1Sc1ccc(Br)cc1CO CHEMBL278165 Ki 0.52 nM
CN(C)CCCN1c2ccccc2CCc2ccccc21 CHEMBL11 Ki 0.52 nM
Cc1cc2c(OC[C@@H](O)CN3CC[C@@H](c4cc5ccccc5s4)C[C@@H]3C)cccc2[nH]1 CHEMBL421660 Ki 0.53 nM
Cc1ccc(Oc2ccccc2CN(C)C)c(N)c1 CHEMBL204199 Ki 0.53 nM
Cc1cc2c(OC[C@@H](O)CN3CC[C@@H](c4ccc5scc(C)c5c4)C[C@@H]3C)cccc2[nH]1 CHEMBL2112356 Ki 0.54 nM
COC(=O)[C@H]1C2CC[C@@H]3C[C@@H]1/C(=C/c1ccc(Cl)c(Cl)c1)CN23 CHEMBL304656 Ki 0.56 nM
CN(C)[C@@H]1CC=C(c2c[nH]c3ccc(C#N)cc23)CC1 CHEMBL234705 IC50 0.56 nM
CN(C)Cc1ccccc1Sc1ccc(CO)cc1N CHEMBL190937 Ki 0.57 nM
Cc1cc2c(OC[C@@H](O)CN3CC[C@@H](c4ccc5c(C)csc5c4)C[C@@H]3C)cccc2[nH]1 CHEMBL2112355 Ki 0.58 nM
CN(C)C[C@H]1C[C@@H]1c1c[nH]c2c(C#N)cccc12 CHEMBL197354 Ki 0.58 nM
C[C@H]1C[C@H](c2cc3cc(Cl)ccc3s2)CCN1C[C@H](O)COc1cccc2[nH]ccc12 CHEMBL79151 Ki 0.58 nM
N#CCCCN(Cc1ccccc1C(F)(F)F)C1CCNCC1 CHEMBL383611 Ki 0.58 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(-c3ccsc3)cc1)N2C CHEMBL595677 Ki 0.58 nM
N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ncc(-c5ccc(F)cc5F)cn4)CC3)c2c1 CHEMBL5438420 IC50 0.58 nM
COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cccc(F)c4)CC3)[C@@H]1CO2 CHEMBL263424 Ki 0.6 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(SC)c(Br)c1)N2C CHEMBL578419 Ki 0.6 nM
CN(C)[C@H]1CC[C@@H](c2c[nH]c3ccc(F)cc23)C1 CHEMBL1275791 IC50 0.63 nM
Clc1ccc([C@@]2(COCC3CC3)[C@@H]3CNC[C@@H]32)cc1Cl CHEMBL598644 pKi 0.631 nM
Clc1ccc([C@]23CNC[C@H]2[C@@H]3COC2CCC2)cc1Cl CHEMBL608430 pKi 0.631 nM
FC(F)(F)COC[C@@H]1[C@H]2CNC[C@]21c1ccc(Cl)c(Cl)c1 CHEMBL597190 pKi 0.631 nM
COC[C@@]12CNCC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1173532 pKi 0.631 nM
CCCCC1(C(=O)c2cc(F)c3[nH]ccc3c2)CCNC1 CHEMBL1224492 pKi 0.631 nM
CC(C)(C)CCC1(C(=O)c2ccc3[nH]ncc3c2)CCNC1 CHEMBL1224319 pKi 0.631 nM
N#Cc1ccn(CC23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)c1 CHEMBL1818465 pKi 0.631 nM
COc1cc(Cl)ccc1O[C@H](c1ccccc1)[C@@H]1CCNC1 CHEMBL2338037 pIC50 0.631 nM
N#Cc1cccc(O[C@H](c2ccccc2)[C@@H]2CCNC2)c1 CHEMBL2337599 pIC50 0.631 nM
Cc1cccc(N2CCN(C[C@H](O)CNC(=O)c3nc(C)n(-c4ccccc4)c3C)CC2)c1C CHEMBL3216076 IC50 0.64 nM
Cc1cccc(N2CCN(C[C@H](O)CNC(=O)c3nc(C)n(-c4ccccc4)c3C)CC2)c1C CHEMBL1852501 IC50 0.64 nM
COC(=O)C1C2CCC(C[C@@H]1c1ccc(I)cc1)CN2C CHEMBL348552 Ki 0.67 nM
COCCOc1cc(CC2CCN(CCc3ccc4c(c3)C(=O)CCC4)CC2)ccc1Br CHEMBL4226053 Ki 0.67 nM
CN(C)C[C@H]1C[C@@H]1c1c[nH]c2ccc(F)cc12 CHEMBL198019 Ki 0.68 nM
CNCCC(Oc1cccc2ccccc12)c1ccco1 CHEMBL337822 Ki 0.7 nM
CC(C)(C#N)CCN(Cc1ccc(F)cc1C(F)(F)F)C1CCNCC1 CHEMBL207634 Ki 0.7 nM
CNCc1cc(C#CCCN2CCCCC2)ccc1Oc1ccc(SC)cc1 CHEMBL393036 Ki 0.7 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(SC)cc1)N2C CHEMBL579056 Ki 0.7 nM
CN(C)CCC(Oc1ccccc1)c1ccc(OCCCN2CCCCC2)cc1 CHEMBL438490 Ki 0.72 nM
Cc1cc2cc(OC3C[C@H]4CC[C@@H](C3)N4)ccc2oc1=O CHEMBL4228747 IC50 0.72 nM
CNC(C)Cc1ccc2c(c1)OCO2 CHEMBL43048 Ki 0.73 nM
COC[C@H]1[C@@H]2CNC[C@@]21c1ccc(Cl)c(Cl)c1 CHEMBL596809 pKi 0.7413 nM
Cc1cc2c(OC[C@@H](O)CN3CC[C@@H](c4ccc5ccsc5c4)C[C@@H]3C)cccc2[nH]1 CHEMBL2112358 Ki 0.75 nM
Cc1cccc(N2CCN(C[C@H](O)CNC(=O)c3nc(C)n(-c4ccccc4F)c3C)CC2)c1C CHEMBL3216077 IC50 0.75 nM
COc1ccc(O[C@H](CC(C)C)[C@@H]2CCNC2)c(C)n1 CHEMBL2386166 Ki 0.75 nM
Cc1cccc(N2CCN(C[C@H](O)CNC(=O)c3nc(C)n(-c4ccccc4F)c3C)CC2)c1C CHEMBL1852507 IC50 0.75 nM
CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 CHEMBL1200781 Ki 0.78 nM
O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1 CHEMBL131495 Log Ki 0.7943 nM
O=C1COc2ccc(CCN3CCN(c4nccc5ccccc45)CC3)cc2N1 CHEMBL490211 pKi 0.7943 nM
Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1 CHEMBL521506 pKi 0.7943 nM
Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cc(F)cc2n1 CHEMBL485491 pKi 0.7943 nM
Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)[C@H](C)C3)cccc2n1 CHEMBL521873 pKi 0.7943 nM
Cc1ccc2c(N3CCN(CCc4cc5c(cc4F)OCC(=O)N5)CC3)cccc2n1 CHEMBL496317 pKi 0.7943 nM
Cc1ccc2c(N3CCN(CCCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cc(F)cc2n1 CHEMBL470217 pKi 0.7943 nM
c1ccc(CN(c2ccc3[nH]ccc3c2)C2CCNCC2)cc1 CHEMBL560535 pKi 0.7943 nM
CCOCC[C@H]1[C@@H]2CNC[C@]12c1ccc(Cl)c(Cl)c1 CHEMBL597608 pKi 0.7943 nM
Cc1ccnn1CC12CNCC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1818452 pKi 0.7943 nM
Cc1cnn(C[C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)c1 CHEMBL1818453 pKi 0.7943 nM
Cc1cc(C(F)(F)F)n(C[C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)n1 CHEMBL1818461 pKi 0.7943 nM
CC(C)c1nnn(C[C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)n1 CHEMBL1818545 pKi 0.7943 nM
Clc1cc(Cl)cc(O[C@H](c2ccccc2)[C@@H]2CCNC2)c1 CHEMBL2337608 pIC50 0.7943 nM
Clc1cccc(O[C@H](c2ccccc2)[C@@H]2CCNC2)c1Cl CHEMBL2337603 pIC50 0.7943 nM
Fc1ccc(CN(CC2CC2)C2CCNCC2)c(C(F)(F)F)c1 CHEMBL207214 Ki 0.8 nM
CCCN(Cc1ccc(F)cc1C(F)(F)F)C1CCNCC1 CHEMBL207854 Ki 0.8 nM
C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CCC1OCCc2cc(C(N)=O)ccc21 CHEMBL234447 Ki 0.8 nM
CNCc1cc(C#CCCN2CCOCC2)ccc1Oc1ccc(SC)cc1 CHEMBL236046 Ki 0.8 nM
COc1ccc(F)cc1CCC[C@H]1CC[C@H](CN)O1 CHEMBL460407 Ki 0.8 nM
CCOCCCCN[C@H](CC(C)C)C1(c2ccc(Cl)c(Cl)c2)CCC1 CHEMBL3897671 Ki 0.8 nM
C=C1CN2C3CCC2C1C(c1ccc(Cl)cc1)C3 CHEMBL378536 Ki 0.82 nM
COc1ccc(O[C@@H](CC(C)C)[C@@H]2CCNC2)c(C)n1 CHEMBL2386165 Ki 0.84 nM
COc1cccc2sc([C@@H]3CCN(C[C@H](O)COc4cccc5[nH]c(C)cc45)[C@@H](C)C3)cc12 CHEMBL129053 Ki 0.86 nM
CN1C2CCC1[C@@H](C(=O)OCc1cn(CCCCCCOC(=O)[C@H]3C4CCC(C[C@@H]3c3ccc(Cl)cc3)N4C)nn1)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL596001 Ki 0.86 nM
COC(=O)[C@H]1[C@@H](c2ccc(I)cc2)C[C@@H]2CC[C@H]1N2C CHEMBL215376 Kd 0.88 nM
COCCOc1cc(CC2CCN(CCc3ccc4occ(O)c(=O)c4c3)CC2)ccc1Br CHEMBL3656920 Ki 0.88 nM
CN(C)CCC=C1c2ccccc2CCc2ccccc21 CHEMBL629 Ki 0.882 nM
CNCc1cc(C#CCCN2CCC(F)CC2)ccc1Oc1ccc(SC)cc1 CHEMBL391074 Ki 0.9 nM
NCCSCCCc1c[nH]c2ccc(F)cc12 CHEMBL2347169 Ki 0.9 nM
C#Cc1ccc(C2CN3CCCC3c3ccccc32)cc1 CHEMBL330666 Ki 0.9 nM
CNCCC(Oc1cccc2ccccc12)c1ccc(F)cc1 CHEMBL342716 Ki 0.95 nM
CN(C)Cc1cc(OCCCF)ccc1Sc1ccc(F)cc1N CHEMBL239301 Ki 0.95 nM
COC(=O)[C@H]1[C@@H](c2ccc(Cl)c(C)c2)C[C@H]2CC[C@H]1N2C CHEMBL457865 Ki 0.95 nM
Clc1ccc([C@]23CNC[C@H]2[C@@H]3COCC2CC2)cc1Cl CHEMBL599639 pKi 0.955 nM
CC(C)CN(Cc1ccc(Cl)cc1Cl)C1CCNCC1 CHEMBL207860 Ki 0.96 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(Br)cc1)N2C CHEMBL218082 Ki 0.96 nM
CN(C)[C@H]1CC[C@H](c2c[nH]c3ccc(C#N)cc23)C1 CHEMBL1275729 IC50 0.97 nM
Cc1ccc(CN(CC(C)C)C2CCNCC2)cc1 CHEMBL380191 Ki 0.99 nM
COC(=O)C1C2CC[C@H](C[C@@H]1c1ccc(Cl)c(C)c1)N2C CHEMBL50858 IC50 1.0 nM
CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccc(CO)cc21 CHEMBL206697 IC50 1.0 nM
CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccc(S(N)(=O)=O)cc21 CHEMBL383706 IC50 1.0 nM
CN(C)C1CC=C(c2c[nH]c3ccc([N+](=O)[O-])cc23)CC1 CHEMBL396537 IC50 1.0 nM
c1ccc(CC2(c3ccc4[nH]ncc4c3)CCNC2)cc1 CHEMBL520869 Ki 1.0 nM
COc1ccc([C@H]2C[C@H]3CC[C@H]([C@H]2C(=O)OCCc2cc(I)c(N)c(I)c2)N3C)cc1 CHEMBL459333 Ki 1.0 nM
CSc1ccc(Oc2ccccc2CN(C)C)cc1 CHEMBL450714 IC50 1.0 nM
O=C1Cc2c(ccc3c2OC[C@H](CNCC2CCc4[nH]c5ccc(F)cc5c4C2)O3)N1 CHEMBL569251 Ki 1.0 nM
CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 CHEMBL1508 Ki 1.0 nM
CCC(=O)N(Cc1ccc2ccccc2c1)C1CCNCC1 CHEMBL567288 IC50 1.0 nM
FC(F)(F)COC[C@]1(c2ccc(Cl)c(Cl)c2)[C@@H]2CNC[C@@H]21 CHEMBL610220 pKi 1.0 nM
Cc1coc([C@H]2[C@@H]3CNC[C@@]32c2ccc(Cl)c(Cl)c2)n1 CHEMBL596796 pKi 1.0 nM
CCC[C@H]1[C@@H]2CNC[C@]12c1ccc(Cl)c(Cl)c1 CHEMBL600645 pKi 1.0 nM
Clc1ccc([C@]23CNC[C@H]2[C@@H]3COC2CCCCC2)cc1Cl CHEMBL605119 pKi 1.0 nM
c1cc2[nH]ncc2cc1N1CCNC[C@H]1CC1CCOCC1 CHEMBL1171007 pKi 1.0 nM
CC(=O)[C@@]12CNCC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1173754 pKi 1.0 nM
CCOC[C@@]12CNCC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1173533 pKi 1.0 nM
CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 CHEMBL1200322 Ki 1.0 nM
Cc1ccc(C(=O)C2(CCC(C)(C)C)CCNC2)cc1Cl CHEMBL1224399 pKi 1.0 nM
CC(C)(C)CCC1(C(=O)c2ccc(Cl)c(Cl)c2)CCNC1 CHEMBL1224400 pKi 1.0 nM
CC(C)(C)CCC1(C(=O)c2ccc(N)c(Cl)c2)CCNC1 CHEMBL1224317 pKi 1.0 nM
CC(C)(C)CCC1(C(=O)c2cc3ccccc3s2)CCNC1 CHEMBL1224237 pKi 1.0 nM
Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4ccc(=O)n5C)[C@@H](C)C3)cc(F)cc2n1 CHEMBL1289617 pKi 1.0 nM
NC[C@H]1Cc2ccccc2[C@H](c2ccc(Cl)c(Cl)c2)C1 CHEMBL1642904 IC50 1.0 nM
NCC[C@@H]1Cc2ccccc2[C@H](c2ccc(Cl)c(Cl)c2)C1 CHEMBL1642912 IC50 1.0 nM
COC(=O)[C@H]1[C@@H](c2ccc(Cl)c(C)c2)C[C@@H]2CC[C@H]1N2C CHEMBL1812745 IC50 1.0 nM
N#Cc1ccn(C[C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)n1 CHEMBL1818459 pKi 1.0 nM
Cc1cc(C(F)(F)F)nn1C[C@@]12CNCC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1818460 pKi 1.0 nM
CN(C)Cc1cc(I)ccc1Sc1ccccc1N CHEMBL2314216 Ki 1.0 nM
Fc1ccc(F)c(O[C@H](c2ccccc2)[C@@H]2CCNC2)c1Cl CHEMBL2338049 pIC50 1.0 nM
Cc1cc(Cl)ccc1O[C@@H](c1ccccc1)[C@H]1CCNC1 CHEMBL2338039 pIC50 1.0 nM
FC(F)(F)c1cc(COCC2(c3ccccc3)CCNCC2)cc(C(F)(F)F)c1 CHEMBL422931 IC50 1.0 nM
Clc1cccc(COc2ccc(Br)cc2OC2CNC2)c1 CHEMBL3260334 Ki 1.0 nM
CCOC(=O)NCCNC(CC(C)C)C1(c2ccc(Cl)c(Cl)c2)CCC1 CHEMBL3704750 Ki 1.0 nM
COCCOc1cc(CC2CCN(CCc3ccc4c(c3)C(=O)CCO4)CC2)ccc1Br CHEMBL4226281 Ki 1.02 nM
CN(C)Cc1ccccc1Sc1ccc(CF)cc1N CHEMBL143707 Ki 1.04 nM
CNCC[C@H](Oc1cccc2cc(O)ccc12)c1cccs1 CHEMBL332098 Ki 1.06 nM
Brc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 CHEMBL4848081 Ki 1.07 nM
CN(C)Cc1ccccc1Sc1ccc(C#N)cc1N CHEMBL106939 Ki 1.1 nM
CNCCC(Oc1cccc2ccccc12)c1ccsc1 CHEMBL142028 Ki 1.1 nM
COc1ccc2cc([C@@H]3CCN(C[C@H](O)COc4cccc5[nH]ccc45)[C@@H](C)C3)sc2c1 CHEMBL78405 Ki 1.1 nM
COCCCN(Cc1ccc(F)cc1C(F)(F)F)C1CCNCC1 CHEMBL207755 Ki 1.1 nM
CSc1ccccc1CN(CC(C)C)C1CCNCC1 CHEMBL438059 Ki 1.1 nM
CNCc1cc(C#CCCN(C)C2CC2)ccc1Oc1ccc(SC)cc1 CHEMBL237512 Ki 1.1 nM
CN(C)Cc1cc(OCCO)ccc1Sc1ccccc1N CHEMBL396402 Ki 1.1 nM
CN(C)CC1CC1c1c[nH]c2ccc(C#N)cc12 CHEMBL1162965 IC50 1.1 nM
COc1ccc(F)cc1CCCC1CCC(CCN)O1 CHEMBL450907 Ki 1.1 nM
CNCCC(Oc1ccc(C(F)(F)F)cc1)c1ccccc1 CHEMBL1201082 Ki 1.1 nM
CN(C)C[C@H]1CCC[C@H]1c1c[nH]c2ccc(C#N)cc12 CHEMBL539470 IC50 1.1 nM
FC(F)Oc1ccc(-c2ccc3c(c2)CN2CCC3(c3ccc(Cl)cc3)CC2)nn1 CHEMBL3673140 IC50 1.1 nM
O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1 CHEMBL4075144 Ki 1.1 nM
CN1Cc2cc(-c3ccc(N)nn3)ccc2[C@H](c2ccc3ccccc3c2)C1 CHEMBL2364614 IC50 1.1 nM
C=Cc1ccc(Sc2ccccc2CN(C)C)c(N)c1 CHEMBL190703 Ki 1.12 nM
C/C=C\c1ccc([C@H]2CC3CCC([C@H]2C(=O)OC)N3C)cc1 CHEMBL435341 IC50 1.15 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(/C=C/I)cc1)N2 CHEMBL173427 Ki 1.15 nM
COc1cccc2sc([C@H]3CCN(C[C@H](O)COc4cccc5[nH]ccc45)[C@H](C)C3)cc12 CHEMBL308388 Ki 1.15 nM
COCCOc1cc(CC2CCN(CCc3ccc4c(c3)C(=O)CCCO4)CC2)ccc1Br CHEMBL4228477 Ki 1.17 nM
COCCCCN[C@H](CC(C)C)C1(c2ccc(Cl)c(Cl)c2)CCC1 CHEMBL3965642 Ki 1.19 nM
CN(C)C[C@@H](c1ccc2ccccc2c1)[C@@H](O)C(C)(C)C CHEMBL543925 Kd 1.2 nM
COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2 CHEMBL318235 Ki 1.2 nM
COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2 CHEMBL328114 Ki 1.2 nM
CC(C)CN(Cc1ccccc1C#N)C1CCNCC1 CHEMBL207407 Ki 1.2 nM
CNCc1cc(C#CCCN2CCN(C(C)C)C(=O)C2)ccc1Oc1ccc(SC)cc1 CHEMBL393009 Ki 1.2 nM
CNCc1cc(C#CCCN2CCOCC2)ccc1Oc1ccc(Cl)cc1 CHEMBL236475 Ki 1.2 nM
CN(C)Cc1cc(OCCO)ccc1Sc1ccc(F)cc1N CHEMBL241646 Ki 1.2 nM
CN(C)C[C@@H]1CCC[C@@H]1c1c[nH]c2ccc(C#N)cc12 CHEMBL539656 IC50 1.2 nM
Clc1ccc(C23CCN(CC2)Cc2cc(OCCCc4cccnc4)ccc23)cc1 CHEMBL3673158 IC50 1.2 nM
COC(=O)C1C2CCC(CC1c1cccc(I)c1)N2 CHEMBL66068 Ki 1.23 nM
COC(=O)C1C2CCC(CC1c1ccc(Cl)c(Cl)c1)N2 CHEMBL169471 IC50 1.24 nM
Cc1ccc2c(N3CCN(CCc4cc(F)c5c(c4)NC(=O)CO5)CC3)cccc2n1 CHEMBL489394 pKi 1.259 nM
Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 CHEMBL490417 pKi 1.259 nM
Fc1cccc(CN(c2ccc3[nH]ccc3c2)C2CCNCC2)c1 CHEMBL564094 pKi 1.259 nM
c1ccc(CN(c2ccc3[nH]ncc3c2)C2CCNCC2)cc1 CHEMBL561598 pKi 1.259 nM
Fc1ccc(OC[C@H]2[C@@H]3CNC[C@@]32c2ccc(Cl)c(Cl)c2)cc1 CHEMBL599240 pKi 1.259 nM
FC(F)(F)COC[C@H]1[C@@H]2CNC[C@@]21c1ccc(Cl)c(Cl)c1 CHEMBL598202 pKi 1.259 nM
CCOC[C@H]1[C@@H]2CN(C)C[C@]12c1ccc(Cl)c(Cl)c1 CHEMBL605502 pKi 1.259 nM
c1ccc(CC2CNCCN2c2ccc3[nH]ncc3c2)cc1 CHEMBL1171975 pKi 1.259 nM
CC(C)OCC1(C(=O)c2ccc(N)c(Cl)c2)CCCN1 CHEMBL1224091 pKi 1.259 nM
Cc1ccc2c(C3CCN(CCc4c(C)ccc5c4ccc(=O)n5C)CC3)cccc2n1 CHEMBL1289721 pKi 1.259 nM
Clc1ccc([C@]23CCNCC2(Cn2ccc4ccccc42)C3)cc1Cl CHEMBL1818546 pKi 1.259 nM
COc1cc(Cl)ccc1O[C@@H](c1ccccc1)[C@H]1CCNC1 CHEMBL2338036 pIC50 1.259 nM
Clc1ccc(O[C@H](c2ccccc2)[C@@H]2CCNC2)cc1 CHEMBL2337597 pIC50 1.259 nM
COC[C@H]1CN[C@H]2CC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL4228464 pKi 1.259 nM
CN(C)Cc1cc(F)ccc1Sc1ccc(CO)cc1N CHEMBL253182 Ki 1.26 nM
CCSc1ccc([C@H]2CC3CCC(N3)[C@H]2C(=O)OC)cc1 CHEMBL574546 Ki 1.26 nM
COC(=O)[C@H]1[C@@H](c2ccc([125I])cc2)CC2CC[C@H]1N2C CHEMBL4066427 Ki 1.27 nM
C/C=C/c1ccc([C@H]2CC3CCC([C@H]2C(=O)OC)N3C)cc1 CHEMBL173594 IC50 1.3 nM
COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccc(Cl)cc4)CC3)[C@@H]1CO2 CHEMBL101411 Ki 1.3 nM
COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccc(F)cc4)CC3)[C@@H]1CO2 CHEMBL98541 Ki 1.3 nM
CCCCN(Cc1ccc(F)cc1C(F)(F)F)C1CCNCC1 CHEMBL426316 Ki 1.3 nM
C[C@H]1CN(c2cccc3cc(C#N)ccc23)CCN1CC[C@H]1OCc2cc(C(N)=O)ccc21 CHEMBL3706925 Ki 1.3 nM
C[C@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@@H]1OCc2cc(C(N)=O)ccc21 CHEMBL3706923 Ki 1.3 nM
CNCc1cc(C#CCCN2CCNC(=O)C2)ccc1Oc1ccc(SC)cc1 CHEMBL237514 Ki 1.3 nM
CN(C)Cc1cc(OCCCO)ccc1Sc1ccccc1N CHEMBL241647 Ki 1.3 nM
c1cc([C@@H]2CN3CCC[C@@H]3c3cc(OCCCN4CCCCC4)ccc32)cs1 CHEMBL394928 Ki 1.3 nM
CN(C)[C@@H]1CC[C@@H](c2c[nH]c3ccc(C#N)cc23)C1 CHEMBL1275731 IC50 1.3 nM
COCCOc1cc(CC2CCN(CCc3ccc4c(c3)C(=O)CC(O)O4)CC2)ccc1Br CHEMBL3656915 Ki 1.3 nM
COC(=O)C1C(c2ccc(C=C(Br)Br)cc2)CC2CCC1N2C CHEMBL14924 Ki 1.35 nM
CNCCC(Oc1ccccc1OC)c1ccccc1 CHEMBL295467 Ki 1.4 nM
COc1cccc2c1O[C@@H](CN1C3C=C(c4ccc5ccccc5c4)CC1CC3)CO2 CHEMBL357321 Ki 1.4 nM
CNCCC(Oc1cccc2ccccc12)c1cccs1 CHEMBL424660 Ki 1.4 nM
COc1ccc2c(c1)C=C[C@@H]1C2=NO[C@H]1CN1CCN(Cc2ccc3ccccc3c2)CC1 CHEMBL2112972 Ki 1.4 nM
CC(C)CN(Cc1ccccc1C(F)(F)F)C1CCNCC1 CHEMBL380890 Ki 1.4 nM
COc1ccc(F)cc1CN(CC(C)C)C1CCNCC1 CHEMBL207810 Ki 1.4 nM
CNCc1cc(C#CCCNC2CC2)ccc1Oc1ccc(Cl)c(Cl)c1 CHEMBL235814 Ki 1.4 nM
CNCc1cc(CCCCN2CCN(C(C)C)CC2)ccc1Oc1ccc(SC)cc1 CHEMBL238141 Ki 1.4 nM
CN(C)Cc1cc(OCCCF)ccc1Sc1ccccc1N CHEMBL393625 Ki 1.4 nM
CN(C)C1CCC(c2c[nH]c3c(Cl)cccc23)C1 CHEMBL1276251 IC50 1.4 nM
CCOCCNC(CC(C)C)C1(c2ccc(Cl)c(Cl)c2)CCC1 CHEMBL3974108 Ki 1.4 nM
COCCOc1cc(CC2CCN(CCc3ccc4c(c3)OCCC4=O)CC2)ccc1Br CHEMBL4226031 Ki 1.41 nM
COc1ccc2c(c1)[C@]13CCCC[C@@H]1[C@H](C2)N(C)CC3 CHEMBL52440 Ki 1.44 nM
CN(C)Cc1ccccc1Sc1ccc(F)cc1N CHEMBL190860 Ki 1.46 nM
COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CN2 CHEMBL2112976 Ki 1.5 nM
C1=C(c2c[nH]c3ncccc23)CCN(CCOc2cccc3[nH]ccc23)C1 CHEMBL104229 Ki 1.5 nM
FC(F)(F)c1ccccc1CN(CC1CC1)C1CCNCC1 CHEMBL377882 Ki 1.5 nM
CCCCN(Cc1ccccc1C(F)(F)F)C1CCNCC1 CHEMBL207023 Ki 1.5 nM
Cc1ccccc1CN(CC(C)C)C1CCNCC1 CHEMBL208067 Ki 1.5 nM
O=C1CCc2ccc(CC3C4CCC3CN(C[C@@H]3COc5c(ccc6c5CC(=O)N6)O3)C4)cc2N1 CHEMBL1087817 Ki 1.5 nM
CN1CCC(COCc2cc(C3CC3)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 CHEMBL2333611 IC50 1.5 nM
COC(=O)[C@H]1[C@@H](c2ccc(I)cc2)C[C@@H]2CC[C@H]1N2C/C=C/I CHEMBL1945251 Ki 1.5 nM
O=c1n(-c2ccc3c(c2)CN2CCC3(c3ccc(Cl)cc3)CC2)nc2ccccn12 CHEMBL3673148 IC50 1.5 nM
Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)ccc(Cl)c2n1 CHEMBL497980 pKi 1.585 nM
COc1cccc(CN(c2ccc3[nH]ccc3c2)C2CCNCC2)c1 CHEMBL550870 pKi 1.585 nM
Clc1ccc([C@]23CCN4CC[C@]2(C4)C3)cc1Cl CHEMBL1172902 pKi 1.585 nM
COC[C@@]12CNCC[C@]1(c1ccc(F)c(Cl)c1)C2 CHEMBL1173413 pKi 1.585 nM
CCCC1(C(=O)c2cc(F)c3[nH]ccc3c2)CCNC1 CHEMBL1224402 pKi 1.585 nM
Clc1cc(Cl)c(Cl)c(O[C@H](c2ccccc2)[C@@H]2CCNC2)c1 CHEMBL2338041 pIC50 1.585 nM
COc1cc([N+](=O)[O-])ccc1O[C@@H](c1ccccc1)[C@H]1CCNC1 CHEMBL2338038 pIC50 1.585 nM
CN(C)Cc1ccccc1Sc1ccccc1N CHEMBL190700 Ki 1.59 nM
COc1ccccc1/C=C(\C)CN1CCN(C[C@@H]2ON=C3c4cc(OC)c(OC)cc4OC[C@H]32)CC1 CHEMBL99868 Ki 1.6 nM
CC(C)CN(Cc1ccccc1Cl)C1CCNCC1 CHEMBL208251 Ki 1.6 nM
CN(C)C1CCC(c2c[nH]c3c(Br)cccc23)C1 CHEMBL1276252 IC50 1.6 nM
CCN(C)C1CCC(c2c[nH]c3ccc(C#N)cc23)C1 CHEMBL1275670 IC50 1.6 nM
Cc1ccc(Sc2ccccc2N2CCNCC2)c(C)c1 CHEMBL2204360 Ki 1.6 nM
CN1CCC(COCc2cc(C#N)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 CHEMBL2333612 IC50 1.6 nM
CN(C)CCCC(=O)c1ccc2c(c1)COC2(CCCN(C)C)c1ccc(F)cc1 CHEMBL4072807 IC50 1.6 nM
Cc1ccc(Sc2ccccc2N2CCNCC2)c(C)c1 CHEMBL2104993 Ki 1.6 nM
COC(=O)C1C2CCC(CC1c1ccc(Cl)cc1)N2 CHEMBL81525 IC50 1.63 nM
CN(C)Cc1ccccc1Oc1ccc(Cl)cc1 CHEMBL257423 IC50 1.68 nM
Cc1cc2c(OC[C@H](O)CN3CC[C@@H](c4ccc5occc5c4)C[C@@H]3C)cccc2[nH]1 CHEMBL329583 Ki 1.69 nM
COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2 CHEMBL92860 Ki 1.7 nM
CNCc1cc(Br)ccc1Oc1ccc(SC)cc1 CHEMBL237521 Ki 1.7 nM
CCOc1ccc([C@H]2C[C@H]3CC[C@H]([C@H]2C(=O)OC)N3C)cc1 CHEMBL458488 Ki 1.7 nM
CS(=O)(=O)Nc1cccc(OCCN2CC3CCC(C2)C3Cc2ccc3c(c2)NC(=O)CC3)c1 CHEMBL1087818 Ki 1.7 nM
CN(C)C1CCC(c2c[nH]c3ccc(F)cc23)C1 CHEMBL1276166 IC50 1.7 nM
FC(F)(F)c1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)c1 CHEMBL2333638 IC50 1.7 nM
CN1Cc2ccccc2C(c2ccc3sccc3c2)C1 CHEMBL3323095 IC50 1.7 nM
O=c1ccoc2ccc(CCN3CCC(Cc4ccc(Br)c(O)c4)CC3)cc12 CHEMBL3656914 Ki 1.7 nM
O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1 CHEMBL4071451 Ki 1.7 nM
CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 CHEMBL4128926 IC50 1.7 nM
COCCOc1cc(CC2CCN(CCc3ccc4c(c3)CCCO4)CC2)ccc1Br CHEMBL4226546 Ki 1.74 nM
CCn1cc([C@H]2C[C@@H]2CN(C)C)c2cc(C#N)ccc21 CHEMBL199054 Ki 1.8 nM
COc1ccc(C2CN(C)Cc3cc(OCCCN4CCN(C(C)C)CC4)ccc32)cc1 CHEMBL394787 Ki 1.8 nM
CNCc1cc(C#CCCN2CCOCC2)ccc1Oc1ccc(Cl)c(Cl)c1 CHEMBL236047 Ki 1.8 nM
Nc1ccc(-c2ccc3c(c2)CNCC3c2ccc(Cl)c(Cl)c2)nn1 CHEMBL3703744 IC50 1.8 nM
Clc1ccc(C2CNCc3cc(-c4ccc5ncnn5c4)ccc32)cc1Cl CHEMBL3703746 IC50 1.8 nM
[11CH3]Sc1ccc([C@@H]2CN3CCC[C@@H]3c3ccccc32)cc1 CHEMBL2114391 Ki 1.82 nM
CN(C)Cc1ccccc1Sc1ccc(CCF)cc1N CHEMBL188964 Ki 1.83 nM
COc1ccc(Sc2ccccc2CN(C)C)c(N)c1 CHEMBL107077 Ki 1.89 nM
COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccsc4)CC3)[C@@H]1CO2 CHEMBL101596 Ki 1.9 nM
CC(C)CN(Cc1ccc(F)cc1)C1CCNCC1 CHEMBL207719 Ki 1.9 nM
CN1C2CCC1C1COC(=O)CCCCCCCCC(=O)Nc3ccc(cc3)C1C2 CHEMBL211372 Ki 1.9 nM
CNCc1cc(C#CCCN2CCOCC2)ccc1Oc1ccc(SC)c(C)c1 CHEMBL391947 Ki 1.9 nM
CNCc1cc(CCCCN2CCSCC2)ccc1Oc1ccc(SC)cc1 CHEMBL236010 Ki 1.9 nM
O=C1CCc2ccc(CC3CCN(C[C@@H]4COc5c(ccc6c5CC(=O)N6)O4)CC3)cc2N1 CHEMBL1087455 Ki 1.9 nM
COc1ccc(O[C@@H](CC(C)C)[C@H]2CCNC2)c(C)n1 CHEMBL2386162 IC50 1.9 nM
CNC(=O)c1ccccc1Sc1ccc(C)cc1[N+](=O)[O-] CHEMBL2113054 Ki 1.94 nM
O[C@H](COc1cccc2[nH]ccc12)CN1CCC(c2cc3ccc(F)cc3s2)CC1 CHEMBL56601 Ki 1.99 nM
Cc1ncc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 CHEMBL489195 pKi 1.995 nM
Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cc(F)cc2n1 CHEMBL513875 pKi 1.995 nM
Fc1ccc(CN(c2ccc3[nH]ccc3c2)C2CCNCC2)cc1 CHEMBL551818 pKi 1.995 nM
COCCC1CNCCN1c1ccc2[nH]ncc2c1 CHEMBL1169916 pKi 1.995 nM
CC(C)(C)CCC1(C(=O)c2ccc3ccccc3n2)CCNC1 CHEMBL1224239 pKi 1.995 nM
CCCC1(C(=O)c2ccc3[nH]ccc3c2)CCCN1 CHEMBL1224164 pKi 1.995 nM
CCCC1(C(=O)c2ccc(N)c(Cl)c2)CCCN1 CHEMBL1224089 pKi 1.995 nM
Cc1coc(C[C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)n1 CHEMBL1818449 pKi 1.995 nM
FC(F)(F)c1ccnn1C[C@@]12CNCC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1818456 pKi 1.995 nM
FC(F)(F)c1ccn(C[C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)n1 CHEMBL1818457 pKi 1.995 nM
Cc1cc(C)n(C[C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)c1 CHEMBL1818468 pKi 1.995 nM
Cc1nc(C)n(CC23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)n1 CHEMBL1818543 pKi 1.995 nM
FC(F)(F)c1ccc(O[C@H](c2ccccc2)[C@H]2CCNC2)cc1 CHEMBL2337600 pIC50 1.995 nM
COC(=O)C1C(c2ccc(Cl)c(Cl)c2)CC2CCC1N2C CHEMBL87031 IC50 2.0 nM
CNCCC(Oc1cccc2ccccc12)c1ccccc1C CHEMBL141741 Ki 2.0 nM
CCN[C@@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 CHEMBL147983 Ki 2.0 nM
N#Cc1ccc2[nH]cc(SC[C@@H]3CN4CCC3CC4)c2c1 CHEMBL179767 IC50 2.0 nM
CN(C)CCCc1c[nH]c2ccc(C#N)cc12 CHEMBL180630 IC50 2.0 nM
O=C(CCCCC1SCC2NC(=O)NC21)NCCN1CC=C(c2c[nH]c3ccccc23)CC1 CHEMBL198525 IC50 2.0 nM
CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccc([S+](C)[O-])cc21 CHEMBL382810 IC50 2.0 nM
CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccc(C(N)=O)cc21 CHEMBL438257 IC50 2.0 nM
CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccc([N+](=O)[O-])cc21 CHEMBL411693 IC50 2.0 nM
CCN1CCN(CCCOc2ccc3c(c2)CN(C)CC3c2ccc(OC)cc2)CC1 CHEMBL396459 Ki 2.0 nM
CNCc1cc(CCCCN2CCN(C3CC3)CC2)ccc1Oc1ccc(SC)cc1 CHEMBL238143 Ki 2.0 nM
COc1ccc(C2CN(C)Cc3cc(OCCCN4CCCCC4)ccc32)cc1 CHEMBL394861 Ki 2.0 nM
CSc1ccc(C2CN(C)Cc3cc(OCCCN4CCC(F)CC4)ccc32)cc1 CHEMBL395368 Ki 2.0 nM
NC(=O)c1cc2cc(C3(Cc4ccccc4)CCNC3)ccc2[nH]1 CHEMBL457931 Ki 2.0 nM
c1ccc2cc(CN(C3CCC3)C3CCNCC3)ccc2c1 CHEMBL512130 IC50 2.0 nM
CSc1ccc(Oc2ccc(Br)cc2CN(C)C)cc1 CHEMBL451120 IC50 2.0 nM
CSc1ccc(Oc2ccncc2CN(C)C)cc1 CHEMBL488326 IC50 2.0 nM
COc1ccc([C@H]2C[C@H]3CC[C@H]([C@H]2C(=O)OCCc2cc(Br)c(N)c(Br)c2)N3C)cc1 CHEMBL516933 Ki 2.0 nM
COc1ccc(F)cc1CCCCC1CCC(CCN)O1 CHEMBL460204 Ki 2.0 nM
CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1cccc(Cl)c1C#N CHEMBL2112075 IC50 2.0 nM
CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1cccc(Cl)c1C#N CHEMBL180672 IC50 2.0 nM
Fc1ccc(COc2ccc(F)cc2C2CCNCC2)cc1 CHEMBL574008 Ki 2.0 nM
Fc1ccc(OCc2ccc(Cl)c(Cl)c2)c(C2CCNCC2)c1 CHEMBL573971 Ki 2.0 nM
Cc1ccc(C2CCNCC2)c(Oc2cccc(F)c2)c1 CHEMBL573898 Ki 2.0 nM
Clc1cccc(Oc2ncccc2C2CCNCC2)c1Cl CHEMBL600854 Ki 2.0 nM
COc1c(F)cccc1CC(c1ccccc1)N1CCNCC1 CHEMBL1086273 Ki 2.0 nM
COc1ccccc1CC(c1ccccc1)N1CCNCC1 CHEMBL214335 Ki 2.0 nM
NC[C@@H]1Cc2ccccc2[C@H](c2ccc(Cl)c(Cl)c2)C1 CHEMBL1642902 IC50 2.0 nM
CCOC(=O)NCCNC(CC(C)C)C1(c2ccc(OCC)cc2)CCC1 CHEMBL3704751 Ki 2.0 nM
COC(=O)[C@H]1[C@@H](c2ccc(Cl)c(Cl)c2)C[C@@H]2CC[C@H]1N2C CHEMBL1945780 IC50 2.0 nM
CNC[C@@H]1C[C@@]1(Oc1cccc2ccccc12)c1cccs1 CHEMBL553224 Ki 2.01 nM
CCc1ccc(Sc2ccccc2CNC)c(N)c1 CHEMBL189375 Ki 2.04 nM
COC[C@@H]1CN[C@H]2CC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL4227688 pKi 2.089 nM
CNCCC(Oc1cccc2ccccc12)c1ccc(C)cc1 CHEMBL141114 Ki 2.1 nM
C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CCC1OCCc2c1sc(C(N)=O)c2Cl CHEMBL197982 IC50 2.1 nM
CC(C)CN(Cc1cc(Cl)ccc1Cl)C1CCNCC1 CHEMBL208535 Ki 2.1 nM
COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccc(F)cc4)CC3)C1CO2 CHEMBL226636 Ki 2.1 nM
C[C@H]1CN(c2ccc3cc(F)ccc3c2)CCN1CC[C@@H]1OCCc2cc(C(N)=O)ccc21 CHEMBL391272 Ki 2.1 nM
COc1ccc(F)cc1CCC1CCC(CCN)O1 CHEMBL464422 Ki 2.1 nM
COc1ccc(F)cc1CC[C@H]1CC[C@H](CCN)O1 CHEMBL462311 Ki 2.1 nM
CN1CCCCC1(C)CCc1c[nH]c2ccc(C#N)cc12 CHEMBL599684 IC50 2.1 nM
CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccc(F)cc2)CC1 CHEMBL2333637 IC50 2.1 nM
COCC(c1ccc2ccccc2c1)C1CCNCC1 CHEMBL2407328 IC50 2.1 nM
Fc1ccc(C23CCN(CC2)Cc2cc(-c4ccc(C(F)(F)F)nn4)ccc23)cc1Cl CHEMBL3673174 IC50 2.1 nM
CNC[C@H](c1ccc2ccccc2c1)[C@H](O)c1ccccc1 CHEMBL4227444 Ki 2.1 nM
COC(=O)C1C(c2ccc3ccccc3c2)CC2CCC1N2C CHEMBL87567 IC50 2.19 nM
CNCCC(Oc1cccc2ccccc12)c1cccc(OC)c1 CHEMBL337791 Ki 2.2 nM
COCCCN(Cc1ccccc1C(F)(F)F)C1CCNCC1 CHEMBL208178 Ki 2.2 nM
CCCN(Cc1ccccc1C(F)(F)F)C1CCNCC1 CHEMBL208121 Ki 2.2 nM
COc1ccc(CN(CC(C)C)C2CCNCC2)c(OC)c1 CHEMBL378070 Ki 2.2 nM
CC(C)CN(Cc1ccccc1OC(F)(F)F)C1CCNCC1 CHEMBL207914 Ki 2.2 nM
Cc1cccc(CN(CC(C)C)C2CCNCC2)c1 CHEMBL381056 Ki 2.2 nM
C[C@H]1CN(c2cccc3cc(C#N)ccc23)CCN1CC[C@@H]1OCCc2cc(C(N)=O)ccc21 CHEMBL233210 Ki 2.2 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(I)cc1)N2C/C=C/CF CHEMBL1214059 Ki 2.2 nM
CN1CCC(COCc2cc(C(F)(F)F)ccn2)(c2ccc(F)cc2)CC1 CHEMBL2333630 IC50 2.2 nM
CN1Cc2cc(-c3cccnn3)ccc2C(c2cc3ccccc3s2)C1 CHEMBL3663912 Ki 2.2 nM
CN1Cc2cc(-c3cccnn3)ccc2C(c2ccc3sccc3c2)C1 CHEMBL3663917 Ki 2.2 nM
COCCOc1cc(CC2CCN(CC(O)c3ccc4c(c3)C(=O)CCO4)CC2)ccc1Br CHEMBL3705032 Ki 2.2 nM
Fc1ccc(C23CCN(Cc4cc(-c5ccc6ncnn6c5)ccc42)C3)cc1Cl CHEMBL3673176 IC50 2.2 nM
O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1 CHEMBL4104622 Ki 2.2 nM
CC[C@H]1C[C@H]2C[C@H]3c4[nH]c5ccc(OC)cc5c4CCN(C2)[C@@H]13 CHEMBL222287 Kinact 2.26 nM
CN1C[C@@H]2CCC[C@]2(c2ccc3ccccc3c2)C1 CHEMBL1813483 pIC50 2.291 nM
OC1(c2ccc3ccccc3c2)c2ccccc2C2=NCCN21 CHEMBL132676 Ki 2.3 nM
COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2 CHEMBL91157 Ki 2.3 nM
CNCCC(Oc1cccc2ccccc12)c1ccccc1OC CHEMBL139106 Ki 2.3 nM
CN(C)C[C@H]1C2CCC(C2)[C@@H]1c1ccc2ccccc2c1 CHEMBL326466 Ki 2.3 nM
CSc1ccc(C2CN(C)Cc3cc(Oc4ccc(CN5CCCCC5)cn4)ccc32)cc1 CHEMBL237862 Ki 2.3 nM
O=S1(=O)N(CCN2CC=C(c3c[nH]c4cc(F)ccc34)CC2)c2cccc3c2N1CCC3 CHEMBL1079460 Ki 2.3 nM
NCCSCCc1c[nH]c2ccc(F)cc12 CHEMBL2347168 Ki 2.3 nM
CC1(C)NCC(c2ccc(Cl)c(Cl)c2)c2ccc(-c3ccc(N)nn3)cc21 CHEMBL3703732 IC50 2.3 nM
Nc1cnc(Oc2ccc3c(c2)CN2CCC3(c3ccc(Cl)cc3)CC2)cn1 CHEMBL3673156 IC50 2.3 nM
C[C@@H](CCNCCCC(N)=O)CC1(c2ccc(Cl)c(Cl)c2)CCC1 CHEMBL3704754 Ki 2.3 nM
Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1 CHEMBL4075673 Ki 2.3 nM
O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1 CHEMBL4091193 Ki 2.3 nM
Cc1ccc(Oc2ccc(Cl)c(Cl)c2)c(CN(C)C)c1 CHEMBL455511 IC50 2.36 nM
COCCOc1cc(CC2CCN(CCc3ccc4c(c3)OCCO4)CC2)ccc1Br CHEMBL4227238 Ki 2.39 nM
CNCCC(Oc1cccc2ccccc12)c1ccccc1 CHEMBL141681 Ki 2.4 nM
CN(C)[C@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 CHEMBL147950 Ki 2.4 nM
CSc1ccc(C2CN(C)Cc3cc(Oc4cc(CN5CCCCC5)ccn4)ccc32)cc1 CHEMBL236784 Ki 2.4 nM
CCC(=O)N(Cc1ccc2ccccc2c1)[C@@H]1CCNC1 CHEMBL576036 IC50 2.4 nM
CNCCC(c1ccccc1)c1cccc2ccccc12 CHEMBL1277686 Ki 2.4 nM
CN(C)[C@@H]1CC[C@H](c2c[nH]c3ccc(F)cc23)C1 CHEMBL1275793 IC50 2.4 nM
CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC(C#N)CC3)n2)(c2ccc(F)cc2)CC1 CHEMBL2333629 IC50 2.4 nM
O=C(OCCF)[C@H]1[C@@H](c2ccc(I)cc2)C[C@@H]2CC[C@H]1N2C/C=C/I CHEMBL3105243 Ki 2.4 nM
Fc1ccc(C23CCN(Cc4cc(-c5ccc(C(F)(F)F)nn5)ccc42)C3)cc1Cl CHEMBL3673177 IC50 2.4 nM
CN(C)Cc1cc(CC(N)=O)ccc1Oc1ccc(Cl)c(Cl)c1 CHEMBL451178 IC50 2.43 nM
[3H]C(CCN(C)C)C1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 CHEMBL1628605 Activity 2.43 nM
COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4cccc(F)c4)CC3)[C@@H]1CO2 CHEMBL95218 Ki 2.5 nM
COCCN(Cc1ccccc1C(F)(F)F)C1CCNCC1 CHEMBL382248 Ki 2.5 nM
Fc1ccc(CN(CC2CCC2)C2CCNCC2)c(C(F)(F)F)c1 CHEMBL207480 Ki 2.5 nM
CNCc1cc(C#CCCN2CCSCC2)ccc1Oc1ccc(SC)cc1 CHEMBL237317 Ki 2.5 nM
CSc1ccc([C@@H]2CN3CCC[C@@H]3c3cc(OCCCN4CCCCC4)ccc32)cc1 CHEMBL238051 Ki 2.5 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(Cl)c(Cl)c1)N2C CHEMBL42553 IC50 2.5 nM
CNCc1cc(C#N)ccc1Oc1ccc(Cl)c(Cl)c1 CHEMBL451076 IC50 2.5 nM
COc1ccc(F)cc1CC[C@H]1CC[C@H](CN)O1 CHEMBL511500 IC50 2.5 nM
CNCC[C@@H](Oc1cccc2ccccc12)c1cccs1 CHEMBL336920 Ki 2.5 nM
N#Cc1ccc2[nH]cc(CCC3CCCCN3)c2c1 CHEMBL590487 IC50 2.5 nM
CC1(C)Cc2cccc(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)c2O1 CHEMBL491839 pKi 2.512 nM
N#Cc1ccc(CN(c2ccc3[nH]ccc3c2)C2CCNCC2)cc1 CHEMBL564285 pKi 2.512 nM
OCC[C@H]1[C@@H]2CNC[C@]12c1ccc(Cl)c(Cl)c1 CHEMBL598216 pKi 2.512 nM
CC(C)CC1(C(=O)c2ccc3[nH]ncc3c2)CCCN1 CHEMBL1224093 pKi 2.512 nM
Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)CC3)cccc2n1 CHEMBL1290716 pKi 2.512 nM
Cc1ccc2c(N3CCN(CCc4cccc5c4ccc(=O)n5C)[C@@H](C)C3)cccc2n1 CHEMBL1287827 pKi 2.512 nM
N#Cc1cccn1C[C@@]12CNCC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1818464 pKi 2.512 nM
Cc1ccc(C)n1C[C@@]12CNCC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1818467 pKi 2.512 nM
Clc1cccc(O[C@H](c2ccccc2)[C@@H]2CCNC2)c1 CHEMBL2337595 pIC50 2.512 nM
COC(=O)C1C2CC[C@H](C[C@@H]1c1ccc(I)cc1)N2C CHEMBL300226 IC50 2.53 nM
COC(=O)C1C(c2ccc(I)cc2)CC2CCC1N2C CHEMBL14391 IC50 2.53 nM
COCCOc1cc(CC2CCN(CCc3ccc4c(c3)S(=O)(=O)CCO4)CC2)ccc1Br CHEMBL4227642 Ki 2.59 nM
CN(C)C[C@H]1C2CCC(C2)[C@@H]1c1ccc2cc(F)ccc2c1 CHEMBL324269 Ki 2.6 nM
CCOC(=O)N1C[C@@H]2C(=NO[C@H]2CN2CCN(C/C=C/c3ccccc3)CC2)c2ccccc21 CHEMBL2112975 Ki 2.6 nM
COc1ccc(F)cc1CCC[C@@H]1CC[C@H](CN)O1 CHEMBL459367 IC50 2.6 nM
Cc1ccc(-c2ccc3c(c2)CN2CCC3(c3ccc(Cl)cc3)CC2)nn1 CHEMBL3673141 IC50 2.6 nM
O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1 CHEMBL4092243 Ki 2.6 nM
COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cccs4)CC3)[C@@H]1CO2 CHEMBL98646 Ki 2.7 nM
CNCc1cc(C#CCCN2CCOCC2)ccc1Oc1ccc(C(F)(F)F)cc1 CHEMBL236675 Ki 2.7 nM
COc1ccc([C@@H]2CN(C)Cc3cc(OCCCN4CCC(F)CC4)ccc32)cc1 CHEMBL235824 Ki 2.7 nM
COc1ccc(C2CN(C)Cc3cc(OCCCN4CCC(F)CC4)ccc32)cc1 CHEMBL233054 Ki 2.7 nM
CN(C)CCC(Oc1cccc(Cl)c1)c1ccc(OCCCN2CCCCC2)cc1 CHEMBL245919 Ki 2.7 nM
c1csc([C@@H]2CN3CCC[C@@H]3c3cc(OCCCN4CCCCC4)ccc32)c1 CHEMBL246716 Ki 2.7 nM
Clc1ccc(Oc2ncccc2C2CCNCC2)c(Cl)c1 CHEMBL598562 Ki 2.7 nM
Cc1c(Cl)cccc1N1CCN(CCCNC(=O)c2nc(C)n(-c3ccc4c(c3)OCCO4)c2C)CC1 CHEMBL3216755 IC50 2.7 nM
COCCOc1cc(CC2CCN(CCc3ccc4c(c3)C(=O)C(O)CO4)CC2)ccc1Br CHEMBL3705036 Ki 2.7 nM
O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1 CHEMBL4084492 Ki 2.7 nM
O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12 CHEMBL4104216 Ki 2.7 nM
CCOc1ccc(C2(C[C@@H](C)CCNCCCC(N)=O)CCC2)cc1 CHEMBL3704757 Ki 2.79 nM
CN(C)CC1C2CCC(C2)C1c1ccc2ccccc2c1 CHEMBL109571 Ki 2.8 nM
FC(F)(F)CCN(Cc1ccccc1C(F)(F)F)C1CCNCC1 CHEMBL377678 Ki 2.8 nM
CCOCCN(Cc1ccc(F)cc1C(F)(F)F)C1CCNCC1 CHEMBL377574 Ki 2.8 nM
CNC[C@@H](O)[C@H](c1cccc(F)c1)N1CCc2cc(Cl)ccc21 CHEMBL598168 IC50 2.8 nM
CN(C)[C@@H]1CC[C@@H](c2c[nH]c3ccc(F)cc23)C1 CHEMBL1275794 IC50 2.8 nM
COc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 CHEMBL2333632 IC50 2.8 nM
O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1 CHEMBL4070254 Ki 2.8 nM
COc1ccc(C2CN(C)Cc3cc(OCCCN4CC(F)(F)C4)ccc32)cc1 CHEMBL396703 Ki 2.9 nM
CNCc1cc(C(=O)N2CCCN(C3CC3)CC2)ccc1Oc1ccc(SC)cc1 CHEMBL257434 Ki 2.9 nM
COC(=O)[C@H]1[C@@H](c2cc(Br)c(OC)c(Br)c2)C[C@H]2CC[C@H]1N2C CHEMBL458282 Ki 2.9 nM
COc1ccc([C@H]2C[C@H]3CC[C@H]([C@H]2C(=O)OCCc2ccc([N+](=O)[O-])cc2)N3C)cc1 CHEMBL457866 Ki 2.9 nM
Fc1ccc2[nH]cc(C3CCC(N4CCCC4)C3)c2c1 CHEMBL1275708 IC50 2.9 nM
Cc1cccc(N2CCN(CC(O)CNC(=O)c3nc(C)n(-c4cccc(Cl)c4)c3C)CC2)c1C CHEMBL3216282 IC50 2.9 nM
FC(F)(F)c1cc(COC[C@]2(c3ccccc3)CCCNCC2)cc(C(F)(F)F)c1 CHEMBL2347852 IC50 2.9 nM
CCOCCCCNC(CC(C)C)C1(c2ccc(SC)cc2)CCC1 CHEMBL3912176 Ki 2.99 nM
CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccc(NS(C)(=O)=O)cc21 CHEMBL381792 IC50 3.0 nM
CNC(=O)c1ccc2c(c1)[C@@H](NC)CC[C@H]2c1ccc(Cl)c(Cl)c1 CHEMBL378379 IC50 3.0 nM
CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccc(C#N)cc21 CHEMBL203741 IC50 3.0 nM
CC(C)OCCN(Cc1ccc(F)cc1C(F)(F)F)C1CCNCC1 CHEMBL208070 Ki 3.0 nM
C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@@H]1OCCc2cc(C(N)=O)ccc21 CHEMBL391271 Ki 3.0 nM
Clc1cccc(CN(Cc2ccccn2)[C@@H]2CCNC2)c1Cl CHEMBL440230 IC50 3.0 nM
CN(C)CCC(Oc1ccc(Cl)c(Cl)c1)c1ccc(OCCCN2CCCCC2)cc1 CHEMBL245920 Ki 3.0 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(Cl)c(Cl)c1)S2 CHEMBL227757 IC50 3.0 nM
Cc1cc(Cl)ccc1Oc1ccncc1CN(C)C CHEMBL401596 IC50 3.0 nM
N#Cc1ccc2cc(CO[C@H]3CCNC3)ccc2c1 CHEMBL469810 IC50 3.0 nM
N#Cc1ccc2ccc(OCC3CCNCC3)cc2c1 CHEMBL444985 IC50 3.0 nM
CN(C)Cc1cc(C(N)=O)ccc1Oc1ccc(OC(F)(F)F)cc1 CHEMBL481695 IC50 3.0 nM
CN(C)Cc1cc(C(N)=O)ccc1Cc1ccc(Cl)c(Cl)c1 CHEMBL479999 IC50 3.0 nM
CSc1ccc(Sc2ccc(NS(C)(=O)=O)cc2CN(C)C)cc1 CHEMBL449015 IC50 3.0 nM
CN(C)Cc1cc(NS(C)(=O)=O)ccc1Sc1ccc(C(F)(F)F)cc1 CHEMBL482295 IC50 3.0 nM
CN(C)Cc1cc(Br)ccc1Oc1ccc(C(F)(F)F)cc1 CHEMBL481527 IC50 3.0 nM
CN(C)Cc1cnccc1Oc1ccc2c(c1)CCS2 CHEMBL491394 IC50 3.0 nM
CNC[C@@H](O)[C@H](c1ccccc1)N(C)c1ccc(OC)cc1 CHEMBL467513 IC50 3.0 nM
Clc1cccc(OC(c2cccnc2)C2CCNCC2)c1 CHEMBL550696 IC50 3.0 nM
Fc1cccc(OC(c2cccnc2)C2CCNCC2)c1F CHEMBL563987 IC50 3.0 nM
Cc1cccc(OC(c2cccnc2)C2CCNCC2)c1C CHEMBL562854 IC50 3.0 nM
Clc1cccc(OC(c2cccnc2)C2CCNCC2)c1Cl CHEMBL559456 IC50 3.0 nM
Clc1cccc(OC(c2cccnc2)[C@H]2CCCNC2)c1Cl CHEMBL563030 IC50 3.0 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(SC)cc1)N2CCCF CHEMBL575199 Ki 3.0 nM
CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1ccccc1C#N CHEMBL382741 IC50 3.0 nM
O=c1[nH]c2cccc(OC3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1 CHEMBL567454 Ki 3.0 nM
CC(C)CN(C(=O)c1ccc2ccccc2c1)[C@H]1CCNC1 CHEMBL567932 IC50 3.0 nM
O=C(c1cccc(Cl)c1Cl)N(c1ccccc1)[C@H]1CCNC1 CHEMBL1079264 Ki 3.0 nM
CC(C)CN(C(=O)c1ccc(Cl)cc1Cl)[C@H]1CCNC1 CHEMBL1079265 Ki 3.0 nM
Cc1c(Cl)cccc1C(=O)N(CC(C)C)[C@H]1CCNC1 CHEMBL1078162 Ki 3.0 nM
CN(C)C1CCC(c2c[nH]c3ccc(Cl)cc23)C1 CHEMBL1276224 IC50 3.0 nM
N#Cc1ccc2[nH]cc(C3CCC(N4CCCC4)C3)c2c1 CHEMBL1277049 IC50 3.0 nM
CN(C)[C@@H]1Cc2ccccc2[C@H](c2ccc(Cl)c(Cl)c2)C1 CHEMBL1642900 IC50 3.0 nM
CN(C)C1CCN(c2ccc(Cl)c(Cl)c2)c2ccccc21 CHEMBL1643510 IC50 3.0 nM
CN(C)CC1(c2ccc3ccccc3c2)CCCCC1 CHEMBL1683902 IC50 3.0 nM
CCN(CC)c1ccc2c(-c3ccc(S(=O)(=O)NCCCCCC(=O)NCc4ccc5c(c4)CO[C@@]5(CCCN(C)C)c4ccc(F)cc4)cc3S(=O)(=O)[O-])c3ccc(=[N+](CC)CC)cc-3oc2c1 CHEMBL3287656 Ki 3.0 nM
CN1Cc2cc(N3CCOCC3)ccc2[C@@H](c2ccc3sccc3c2)C1 CHEMBL3323181 IC50 3.0 nM
FC(F)Oc1ccc2c(c1)CN1CCC2(c2ccc(Cl)c(Cl)c2)CC1 CHEMBL3673168 IC50 3.0 nM
COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1 CHEMBL814 Ki 3.08 nM
OCCN(Cc1ccc(F)cc1C(F)(F)F)C1CCNCC1 CHEMBL207635 Ki 3.1 nM
CC(C)CN(Cc1ccc(F)cc1F)C1CCNCC1 CHEMBL207807 Ki 3.1 nM
CN(C)C1CC=C(c2c[nH]c3ccccc23)CC1 CHEMBL231809 IC50 3.1 nM
COC(=O)[C@H]1[C@@H](c2ccc(OC)c(Br)c2)C[C@H]2CC[C@H]1N2C CHEMBL513090 Ki 3.1 nM
CN1CCC(COCc2cncc(Br)c2)(c2ccccc2)CC1 CHEMBL2333646 IC50 3.1 nM
Clc1cc(N2CCNCC2Cc2ccccc2)cc2cc[nH]c12 CHEMBL1170210 pKi 3.162 nM
COC[C@@]12CNCC[C@]1(c1ccc(OC(F)(F)F)cc1)C2 CHEMBL1169622 pKi 3.162 nM
CCOCC1(C(=O)c2cc(F)c3[nH]ccc3c2)CCNC1 CHEMBL1224491 pKi 3.162 nM
CC(C)(C)CCC1(C(=O)c2cc(F)c(Cl)c(Cl)c2)CCNC1 CHEMBL1224401 pKi 3.162 nM
Cc1ncoc1C[C@@]12CNCC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1818450 pKi 3.162 nM
Cc1nc(C)n(C[C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)n1 CHEMBL1818542 pKi 3.162 nM
Clc1ccc(O[C@@H](c2ccccc2)[C@H]2CCNC2)c(Cl)c1 CHEMBL2337604 pIC50 3.162 nM
COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cc(F)ccc4F)CC3)[C@@H]1CO2 CHEMBL319119 Ki 3.2 nM
COc1ccc(C2CN(C)Cc3cc(OCCCN4CCC(CO)CC4)ccc32)cc1 CHEMBL233471 Ki 3.2 nM
CSc1ccc(C2CN(C)Cc3cc(Oc4ncc(CN5CCCCC5)s4)ccc32)cc1 CHEMBL238055 Ki 3.2 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc([S+](C)[O-])c(Br)c1)N2C CHEMBL574020 Ki 3.2 nM
O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1 CHEMBL4087852 Ki 3.2 nM
CC(c1ccccc1Oc1ccc(Cl)c(Cl)c1)N(C)C CHEMBL487053 IC50 3.27 nM
CNCc1cc(F)ccc1Oc1ccc(Cl)c(Cl)c1 CHEMBL488060 IC50 3.28 nM
COc1ccc([C@@H]2CN3CCC[C@@H]3c3cc(OCCCN4CCCCC4)ccc32)cc1 CHEMBL235614 Ki 3.3 nM
CN(C)C1CCC(c2c[nH]c3c(F)cccc23)C1 CHEMBL1276250 IC50 3.3 nM
CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC(C#N)C3)n2)(c2ccc(F)cc2)CC1 CHEMBL2333627 IC50 3.3 nM
CN1Cc2cc(CN3CCOCC3)ccc2C(c2cc3ccccc3s2)C1 CHEMBL3663914 Ki 3.3 nM
O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(Cl)c1 CHEMBL4066532 Ki 3.3 nM
CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12 CHEMBL3306803 IC50 3.3 nM
CCOc1ccc(C2(C(CC(C)C)NCCSCC)CCC2)cc1 CHEMBL3986502 Ki 3.31 nM
COCCOc1cc(CC2CCN(CCc3ccc4c(c3)C(=O)CCO4)CC2)ccc1Cl CHEMBL4228158 Ki 3.37 nM
CCNCCCOc1ccc2c(c1)CN(C)CC2c1ccc(OC)cc1 CHEMBL396945 Ki 3.4 nM
CNCc1ccc(C#CCCN2CCOCC2)cc1Oc1ccc(SC)cc1 CHEMBL235794 Ki 3.4 nM
CN(C)Cc1ccc2c(c1)CN(C)CC2c1ccc2sccc2c1 CHEMBL3323179 Ki 3.4 nM
Cc1cccc2c1C(c1ccc3ccccc3c1)CN(C)C2 CHEMBL3964962 Ki 3.4 nM
O=C1NC2C=CC(c3ccc4c(c3)CN3CCC4(c4ccc(Cl)cc4)CC3)=CC2O1 CHEMBL3673147 IC50 3.4 nM
[C-]#[N+]c1cccc(-c2ccc3c(c2)CN2CCC3(c3ccc(Cl)cc3)CC2)c1 CHEMBL3673152 IC50 3.4 nM
C#Cc1ccc([C@@H]2C[C@H]3CC[C@@H](N3)[C@H]2C(=O)OC)cc1 CHEMBL394158 Ki 3.45 nM
Cc1ccc(Oc2ccccc2CN(C)C)cc1 CHEMBL454288 IC50 3.46 nM
CNCCC(Oc1cccc2ccccc12)c1ccc(OC)cc1 CHEMBL415244 Ki 3.5 nM
C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OCCN(C)C)cc4OC[C@H]32)CC1 CHEMBL176261 Ki 3.5 nM
CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2)cc(C(C)=O)c1 CHEMBL217987 Ki 3.5 nM
CNCc1cc(C#CCCN2CCN(C3CC3)CC2)ccc1Oc1ccc(SC)cc1 CHEMBL238182 Ki 3.5 nM
COC(=O)[C@H]1[C@@H](c2ccc(OC)c(I)c2)C[C@H]2CC[C@H]1N2C CHEMBL457415 Ki 3.5 nM
COc1ccc([C@H]2C[C@H]3CC[C@H]([C@H]2C(=O)OCCc2ccc(N)c(I)c2)N3C)cc1 CHEMBL459332 Ki 3.5 nM
CS(=O)(=O)N(Cc1ccc2ccccc2c1)[C@H]1CCNC1 CHEMBL567943 IC50 3.5 nM
CS(=O)(=O)N(Cc1ccc2ccccc2c1)C1CCNCC1 CHEMBL568350 IC50 3.5 nM
CN1C2CCC1[C@@H](C(=O)OCc1cn(CCCCCCCOC(=O)[C@H]3C4CCC(C[C@@H]3c3ccc(Cl)cc3)N4C)nn1)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL595190 Ki 3.5 nM
O=c1ccoc2ccc(CCN3CCC(Cc4ccc(Br)c(OCCO)c4)CC3)cc12 CHEMBL3705038 Ki 3.5 nM
O=c1[nH]c2ccc(-c3ccc4c(c3)CN3CCC4(c4ccc(Cl)c(Cl)c4)C3)cc2o1 CHEMBL3673137 IC50 3.5 nM
Nc1cnc(-c2ccc3c(c2)CN2CCC3(c3ccc(Cl)cc3)CC2)cn1 CHEMBL3673144 IC50 3.5 nM
O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1 CHEMBL4080399 Ki 3.5 nM
CN(C)Cc1ccccc1Sc1ccc(CCCF)cc1N CHEMBL363396 Ki 3.58 nM
CNC[C@H]1C2CCC(C2)[C@@H]1c1ccc2ccccc2c1 CHEMBL111128 Ki 3.6 nM
C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(O)cc4OC[C@H]32)CC1 CHEMBL180470 Ki 3.6 nM
FC(F)(F)c1ccccc1CN(C1CCCC1)C1CCNCC1 CHEMBL208191 Ki 3.6 nM
CNCc1cc(C#CCCN2CCCN(C(C)C)CC2)ccc1Oc1ccc(SC)cc1 CHEMBL398981 Ki 3.6 nM
CNCc1cc(C#CCCN2CCOCC2)ccc1Oc1ccc(F)cc1Cl CHEMBL397577 Ki 3.6 nM
FC(F)Oc1ccc(-c2ccc3c(c2)CNCC3c2ccc(Cl)c(Cl)c2)nn1 CHEMBL3703731 IC50 3.6 nM
O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(F)c1 CHEMBL4095555 Ki 3.6 nM
COc1ccc(CN(C)C)c(Oc2ccc(Cl)c(Cl)c2)c1 CHEMBL455423 IC50 3.61 nM
CN1C[C@H]2CCC[C@@]2(c2ccc(Cl)c(Cl)c2)C1 CHEMBL1813484 pIC50 3.631 nM
CNCC[C@H](Oc1cccc2c(OC)c(O)ccc12)c1cccs1 CHEMBL325669 Ki 3.66 nM
CSc1ccc([C@@H]2CN(C)Cc3cc(OCCCN4CCOCC4)ccc32)cc1 CHEMBL257917 Ki 3.7 nM
CCN(C)C1CCC(c2c[nH]c3ccc(F)cc23)C1 CHEMBL1275671 IC50 3.7 nM
COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1 CHEMBL268258 Ki 3.77 nM
Cc1cc2c(OC[C@@H](O)CN3CC[C@@H](c4ccc5ccoc5c4)C[C@@H]3C)cccc2[nH]1 CHEMBL2112354 Ki 3.77 nM
CNCc1cc(OC)ccc1Oc1ccc(Cl)c(Cl)c1 CHEMBL529660 IC50 3.77 nM
CNCc1cc(C(N)=O)ccc1Oc1ccc(Cl)c(Cl)c1 CHEMBL455426 IC50 3.78 nM
CNCCC(Oc1cccc2ccccc12)c1ccc(Cl)cc1 CHEMBL139245 Ki 3.8 nM
COc1ccc(C2CN(C)Cc3cc(OCCCN4CCC(O)CC4)ccc32)cc1 CHEMBL394800 Ki 3.8 nM
CSc1ccc(C2CN(C)Cc3cc(Oc4ccc(CN5CCCCC5)cc4)ccc32)cc1 CHEMBL237861 Ki 3.8 nM
CSc1ccc(C2CN(C)Cc3cc(OCCCN4CCOCC4)ccc32)cc1 CHEMBL246955 Ki 3.8 nM
CN(C)C[C@@H]1CCC[C@H]1c1ccc2[nH]cc(C#N)c2c1 CHEMBL2380980 IC50 3.8 nM
Clc1ccc(C23CCN(CC2)Cc2cc(-c4cccnn4)ccc23)cc1Cl CHEMBL3673161 IC50 3.8 nM
CCCOCCCN[C@H](CC(C)C)C1(c2ccc(Cl)c(Cl)c2)CCC1 CHEMBL3903154 Ki 3.8 nM
O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1 CHEMBL4100951 Ki 3.8 nM
COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 CHEMBL637 Ki 3.814 nM
Cc1ccc(-n2c(C)nc(C(=O)NCC(O)CN3CCN(c4cccc(C)c4C)CC3)c2C)cc1 CHEMBL3681370 IC50 3.89 nM
Clc1ccccc1CC(c1ccccc1)N1CCNCC1 CHEMBL534942 IC50 3.9 nM
Clc1cccc(CC(c2ccccc2)N2CCNCC2)c1Cl CHEMBL214056 IC50 3.9 nM
CN1CCCCC1CCc1c[nH]c2ccc(C#N)cc12 CHEMBL606244 IC50 3.9 nM
CCCc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3C)CC2)c(C)n1-c1ccccc1 CHEMBL3216508 IC50 3.9 nM
CCN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 CHEMBL2333621 IC50 3.9 nM
Cc1cccc(S(=O)(=O)NCCCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1 CHEMBL4080369 Ki 3.9 nM
Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)ccc(F)c2n1 CHEMBL497979 pKi 3.981 nM
Cc1ccc2c(N3C[C@H]4C[C@@H]3CN4CCc3ccc4c(c3)NC(=O)CO4)cccc2n1 CHEMBL523064 pKi 3.981 nM
N#Cc1ccccc1CN(c1ccc2[nH]ccc2c1)C1CCNCC1 CHEMBL550469 pKi 3.981 nM
Fc1ccccc1CN(c1ccc2[nH]ccc2c1)C1CCNCC1 CHEMBL557119 pKi 3.981 nM
Cn1ccc2cc(N(Cc3ccccc3)C3CCNCC3)ccc21 CHEMBL552938 pKi 3.981 nM
CN(C)C[C@H]1[C@@H]2CNC[C@@]21c1ccc(Cl)c(Cl)c1 CHEMBL611990 pKi 3.981 nM
c1cc2[nH]ncc2cc1N1CCNCC1CC1CCOCC1 CHEMBL1170396 pKi 3.981 nM
CCCCC1CNCCN1c1ccc2[nH]ncc2c1 CHEMBL1172525 pKi 3.981 nM
c1ccc(CCC2CNCCN2c2ccc3[nH]ncc3c2)cc1 CHEMBL1170373 pKi 3.981 nM
COC[C@@]12CNC[C@@H](F)[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1173520 pKi 3.981 nM
O=C(c1cc(F)c2[nH]ccc2c1)C1(Cc2ccccc2)CCNC1 CHEMBL1224563 pKi 3.981 nM
Cc1ccc2c(N3CCN(CCc4c(C)ccc5c4ccc(=O)n5C)[C@H](C)C3)cccc2n1 CHEMBL1289277 pKi 3.981 nM
Clc1ccc([C@]23CCNC[C@@]2(Cn2cncn2)C3)cc1Cl CHEMBL1818469 pKi 3.981 nM
Fc1cc(F)c(Cl)c(O[C@H](c2ccccc2)[C@@H]2CCNC2)c1Cl CHEMBL2338046 pIC50 3.981 nM
Clc1ccc(Cl)c(O[C@H](c2ccccc2)[C@@H]2CCNC2)c1Cl CHEMBL2338043 pIC50 3.981 nM
Clc1ccc(Cl)c(O[C@@H](c2ccccc2)[C@H]2CCNC2)c1Cl CHEMBL2338042 pIC50 3.981 nM
Fc1cc(F)cc(O[C@H](c2ccccc2)[C@@H]2CCNC2)c1 CHEMBL2338033 pIC50 3.981 nM
Clc1ccccc1O[C@H](c1ccccc1)[C@@H]1CCNC1 CHEMBL2337593 pIC50 3.981 nM
CNCCC(Oc1cccc2ccccc12)c1cccc(C)c1 CHEMBL139277 Ki 4.0 nM
CN[C@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 CHEMBL146332 Ki 4.0 nM
CN(C)CCCc1c[nH]c2ccc(F)cc12 CHEMBL361949 IC50 4.0 nM
CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccc(-n3cncn3)cc21 CHEMBL383427 IC50 4.0 nM
CC(C)(O)CN(Cc1ccc(F)cc1C(F)(F)F)C1CCNCC1 CHEMBL209094 Ki 4.0 nM
N#Cc1cccc(CC(c2ccccc2)N2CCNCC2)c1 CHEMBL386223 IC50 4.0 nM
COC(=O)C1C2CC[C@H](C[C@@H]1c1ccc(Cl)cc1)N2C CHEMBL610897 Ki 4.0 nM
COC(=O)[C@H]1[C@@H](c2ccc(I)cc2)C[C@H]2CC[C@@H]1N2C CHEMBL242338 Ki 4.0 nM
COc1ccc(C2CN(C)Cc3cc(OCCCN4CCN(c5ccncc5)CC4)ccc32)cc1 CHEMBL242820 Ki 4.0 nM
CCN(CC)CCCOc1ccc2c(c1)CN(C)CC2c1ccc(OC)cc1 CHEMBL427845 Ki 4.0 nM
Clc1cccc(CN(CC2CC2)[C@@H]2CCNC2)c1Cl CHEMBL395931 IC50 4.0 nM
CN(C)CCC(Oc1cccc(Br)c1)c1ccc(OCCCN2CCCCC2)cc1 CHEMBL245921 Ki 4.0 nM
CN(C)Cc1ccccc1Oc1ccc(Cl)cc1Cl CHEMBL402057 IC50 4.0 nM
CN(C)Cc1cnccc1Oc1ccc(Cl)cc1Br CHEMBL256136 IC50 4.0 nM
CNCc1cnc(C)cc1Oc1ccc(Cl)cc1OC CHEMBL403078 IC50 4.0 nM
CCOC(=O)c1cc2cc(C3(Cc4ccccc4)CCNC3)ccc2[nH]1 CHEMBL512551 Ki 4.0 nM
Cn1ccc2cc(C3(Cc4ccccc4)CCNC3)ccc21 CHEMBL459176 Ki 4.0 nM
Fc1ccc2cc(CO[C@@H]3CCNC3)ccc2c1 CHEMBL469811 IC50 4.0 nM
Cc1c(CCN2CCNCC2)ccc2cc(F)ccc12 CHEMBL443090 IC50 4.0 nM
CNCc1cc(C(N)=O)ccc1Cc1ccc(Cl)c(Cl)c1 CHEMBL451165 IC50 4.0 nM
CSc1ccc(Oc2ccc(Cl)cc2CN(C)C)cc1 CHEMBL448689 IC50 4.0 nM
CNCc1ccccc1Cc1ccc(SC)cc1 CHEMBL492841 IC50 4.0 nM
CSc1ccc(Oc2ccc(S(N)(=O)=O)cc2CN(C)C)cc1 CHEMBL505147 IC50 4.0 nM
COc1ccc(F)cc1CCCC[C@H]1CC[C@H](CN)O1 CHEMBL455221 Ki 4.0 nM
NCC1CCC(c2ccc3ccccc3c2)O1 CHEMBL504028 IC50 4.0 nM
Clc1cccc(OC(c2cccnc2)[C@@H]2CCCNC2)c1Cl CHEMBL549825 IC50 4.0 nM
O=C1Cc2c(ccc3c2OC[C@H](CNCCCC2CCc4c([nH]c5ccc(F)cc45)C2)O3)N1 CHEMBL566379 Ki 4.0 nM
CCN1CCCCC1CCc1c[nH]c2ccc(C#N)cc12 CHEMBL592776 IC50 4.0 nM
CC(C)(C)CN(C(=O)c1cccc(Cl)c1Cl)[C@H]1CCNC1 CHEMBL1080790 Ki 4.0 nM
CC(C)CN(C(=O)c1ccc(Cl)c(Cl)c1)[C@H]1CCNC1 CHEMBL1078742 Ki 4.0 nM
CN1CCC(COCc2cc(C(F)(F)F)cc(N3CC=CC3)n2)(c2ccc(F)cc2)CC1 CHEMBL2333626 IC50 4.0 nM
CN(C)CCCC1(c2ccc(F)cc2)OCc2c1ccc1ccccc21 CHEMBL4093518 IC50 4.0 nM
CNCc1ccccc1Oc1ccc(Cl)c(Cl)c1 CHEMBL488912 IC50 4.02 nM
CNCCC(Oc1cccc2ccccc12)c1ccc(Br)cc1 CHEMBL139168 Ki 4.1 nM
CC(C)CN(Cc1c(F)cccc1C(F)(F)F)C1CCNCC1 CHEMBL379699 Ki 4.1 nM
CN(C)CC1CC1c1cccc2cc(C#N)ccc12 CHEMBL401347 IC50 4.1 nM
COc1ccc2c(c1)CCN([C@H]1CC[C@@H](c3c[nH]c4ccc(C#N)cc43)CC1)C2 CHEMBL294481 Ki 4.1 nM
COc1ccc([C@H]2C[C@H]3CC[C@H]([C@H]2C(=O)OCCc2ccc(N)c(Br)c2)N3C)cc1 CHEMBL514424 Ki 4.1 nM
CN1Cc2cc(-c3cccnn3)ccc2C(c2cc3ccccc3o2)C1 CHEMBL3663918 Ki 4.1 nM
O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1 CHEMBL4077937 Ki 4.1 nM
[11CH3]Oc1ccc2c(c1)CCN(CCCc1c[nH]c3ccc(F)cc13)C2 CHEMBL482903 Ki 4.11 nM
Cc1ccc([S+]([O-])c2ccccc2CN(C)C)c(N)c1 CHEMBL203821 Ki 4.15 nM
COC(=O)[C@@H]1[C@H]2CC[C@H](C[C@H]1c1ccc(I)cc1)N2 CHEMBL398370 Ki 4.16 nM
CNCc1ccc(Cl)cc1Oc1ccc(C)c(Cl)c1 CHEMBL451330 IC50 4.19 nM
CC(C)(C#N)CN(Cc1ccc(F)cc1C(F)(F)F)C1CCNCC1 CHEMBL381079 Ki 4.2 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(I)cc1)N2C CHEMBL610766 Ki 4.2 nM
CC1(C)NCC(c2ccc(Cl)c(Cl)c2)c2ccc(-c3ccc4ncnn4c3)cc21 CHEMBL3703748 IC50 4.2 nM
Clc1ccc(C23CCN(CC2)Cc2cc(OCCCc4ccncc4)ccc23)cc1 CHEMBL3673157 IC50 4.2 nM
O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1 CHEMBL4066971 Ki 4.2 nM
CNCc1ccc(Cl)cc1Oc1ccc(Cl)c(C)c1 CHEMBL452091 IC50 4.27 nM
CC(C)(C)CN(Cc1ccccc1C(F)(F)F)C1CCNCC1 CHEMBL208420 Ki 4.3 nM
CSc1ccc(C2CN(C)Cc3cc(Oc4nc(CN5CCCCC5)cs4)ccc32)cc1 CHEMBL238054 Ki 4.3 nM
CN1Cc2cc(OCCCN3CCC(F)CC3)ccc2C(c2ccc(OC(F)F)cc2)C1 CHEMBL246954 Ki 4.3 nM
COc1cccc(C2CN(C)Cc3cc(OCCCN4CCC(F)CC4)ccc32)c1 CHEMBL397299 Ki 4.3 nM
COC(=O)[C@H]1[C@@H](c2ccc(OC)cc2)C[C@H]2CC[C@H]1N2C CHEMBL512202 Ki 4.3 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc([S+](C)[O-])cc1)N2C CHEMBL574317 Ki 4.3 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(OC)cc1)N2C CHEMBL574081 Ki 4.3 nM
CN(C)C1CCC(c2c[nH]c3ccc(Br)cc23)C1 CHEMBL1276225 IC50 4.3 nM
CN1CCC(COCc2cc(C(F)(F)F)cc(C#N)n2)(c2ccccc2)CC1 CHEMBL2333631 IC50 4.3 nM
CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccc(F)cc2)CC1 CHEMBL2333643 IC50 4.3 nM
CNC[C@@H]1CCC[C@H]1c1ccc2[nH]cc(C#N)c2c1 CHEMBL2380975 IC50 4.3 nM
COc1c(C2CN(C)Cc3ccccc32)ccc2sccc12 CHEMBL3663915 Ki 4.3 nM
FC(F)(F)c1ccc(Oc2ccc3c(c2)CN2CCC3(c3ccc(Cl)cc3)CC2)nn1 CHEMBL3673154 IC50 4.3 nM
Clc1ccc(C(Oc2ccccc2)C2CNC2)cc1Cl CHEMBL2219884 IC50 4.3 nM
O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1 CHEMBL4062817 Ki 4.3 nM
Cc1cc2c(OC[C@H](O)CN3CC[C@@H](c4cccc5sccc45)C[C@@H]3C)cccc2[nH]1 CHEMBL313023 Ki 4.35 nM
CC(C)c1nc(C2CCN(CCCCc3c[nH]c4ccc(C#N)cc34)CC2)cn1-c1ccc(Oc2ccc(Cl)cc2)cc1 CHEMBL5176363 IC50 4.36 nM
CNCc1cc(F)c(Cl)cc1Oc1ccc(Cl)c(Cl)c1 CHEMBL455675 IC50 4.37 nM
CNC[C@H]1C2CCC(C2)[C@@H]1c1ccc2cc(F)ccc2c1 CHEMBL432022 Ki 4.4 nM
CN1Cc2cc(N3CCOCC3)ccc2C(c2cc3ccccc3s2)C1 CHEMBL3323184 IC50 4.4 nM
Fc1ccc(C23CCN(CC2)Cc2cc(-c4ccc5ncnn5c4)ccc23)cc1Cl CHEMBL3673175 IC50 4.4 nM
CCc1nc(C2CCN(CCCCc3c[nH]c4ccc(C#N)cc34)CC2)cn1-c1ccc(Oc2ccc(Cl)cc2)cc1 CHEMBL5191418 IC50 4.4 nM
COc1ccc([C@]23CCC[C@H]2CN(C)C3)cc1 CHEMBL1813480 pIC50 4.467 nM
COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2 CHEMBL419316 Ki 4.5 nM
Fc1ccc2[nH]cc(CCCNCCOc3cc(Cl)cc4[nH]cnc34)c2c1 CHEMBL338520 IC50 4.5 nM
COCCOc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1 CHEMBL435352 Ki 4.5 nM
CCSc1ccc([C@H]2CC3CCC([C@H]2C(=O)OC)N3C)cc1 CHEMBL575854 Ki 4.5 nM
CC(=O)N(Cc1ccc2ccccc2c1)C1CCNCC1 CHEMBL567944 IC50 4.5 nM
CN1Cc2cc(N3CCOCC3)ccc2C(c2ccc3ccsc3c2)C1 CHEMBL3323183 IC50 4.5 nM
N#Cc1ccc2[nH]cc([C@H]3CC[C@@H](N4CCc5ccccc5C4)CC3)c2c1 CHEMBL54465 Ki 4.51 nM
CNCc1cc(F)c(OC)cc1Oc1ccc(Cl)c(Cl)c1 CHEMBL454657 IC50 4.51 nM
FC(F)(F)CN(Cc1ccccc1C(F)(F)F)C1CCNCC1 CHEMBL382554 Ki 4.6 nM
Cc1c(CN([C@@H]2CCNC2)S(C)(=O)=O)ccc2cc(F)ccc12 CHEMBL576821 IC50 4.6 nM
COCCOc1cc(CC2CCN(CCc3ccc4c(c3)C(O)CCO4)CC2)ccc1Br CHEMBL3950204 Ki 4.6 nM
Clc1ccc(C23CCN(Cc4cc(-c5ccc6ncnn6c5)ccc42)C3)cc1Cl CHEMBL3673136 IC50 4.6 nM
O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1 CHEMBL4103725 Ki 4.6 nM
CCc1sc(C2CCN(CCCCc3c[nH]c4ccc(C#N)cc34)CC2)nc1-c1ccc(Oc2ccc(Cl)cc2)cc1 CHEMBL5180472 IC50 4.6 nM
COC(=O)C1C2CCC(CC1c1ccc(Cl)c(Cl)c1)O2 CHEMBL316342 IC50 4.67 nM
CNCc1ccc(Cl)cc1Oc1ccc(C)c(C)c1 CHEMBL475121 IC50 4.67 nM
COC(=O)[C@H]1[C@@H](c2ccc(Cl)c(Cl)c2)C[C@@H]2CC[C@H]1O2 CHEMBL5271116 IC50 4.67 nM
O=C1NCN(c2ccccc2)C12CCN(CCCCc1c[nH]c3ccccc13)CC2 CHEMBL3818478 pKi 4.677 nM
O=C(CCCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1nc2ccccc2s1 CHEMBL3818881 pKi 4.677 nM
COc1cccc2c1O[C@@H](CN1C3C=C(c4ccc(Cl)c(Cl)c4)CC1CC3)CO2 CHEMBL149776 Ki 4.69 nM
CCN[C@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 CHEMBL356552 Ki 4.7 nM
CCOc1ccc(C2CN(C)Cc3cc(OCCCN4CCC(F)CC4)ccc32)cc1 CHEMBL246127 Ki 4.7 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(Cl)c(Cl)c1)O2 CHEMBL390929 IC50 4.7 nM
N[C@H]1CC[C@@](COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)(c2ccccc2)C1 CHEMBL3126960 IC50 4.7 nM
Clc1ccc(C23CCN(CC2)Cc2cc(Oc4cnccn4)ccc23)cc1Cl CHEMBL3673166 IC50 4.7 nM
CN1C[C@@H]2CCCC[C@]2(c2ccc3ccccc3c2)C1 CHEMBL1813313 pIC50 4.786 nM
COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccsc4)CC3)[C@@H]1CO2 CHEMBL328195 Ki 4.8 nM
CN[C@@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 CHEMBL341898 Ki 4.8 nM
COC(=O)[C@@H]1C2CCC(C[C@H]1c1ccc(Cl)cc1)N2C CHEMBL375888 Ki 4.8 nM
COc1ccc(C2CN(C)Cc3cc(OCCCN4CCC4)ccc32)cc1 CHEMBL234526 Ki 4.8 nM
COC(=O)[C@H]1[C@@H](c2ccc(OC)c(F)c2)C[C@H]2CC[C@H]1N2C CHEMBL458072 Ki 4.8 nM
CNCc1cc(Br)ccc1Oc1ccc(Cl)c(Cl)c1 CHEMBL488435 IC50 4.8 nM
CCNc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 CHEMBL2333619 IC50 4.8 nM
CC1(C)NCC(c2ccc(Cl)c(Cl)c2)c2ccc(-c3cnccn3)cc21 CHEMBL3703728 IC50 4.8 nM
FC(F)(F)c1ccc(Oc2ccc3c(c2)CN2CCC3(c3ccc(Cl)c(Cl)c3)CC2)nn1 CHEMBL3673167 IC50 4.8 nM
O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12 CHEMBL4069237 Ki 4.8 nM
Cc1cccc(N2CCN(CCCNC(=O)c3nc(C)n(-c4cccc(Cl)c4)c3C)CC2)c1C CHEMBL3216974 IC50 4.88 nM
CNCC1C2CCC(C2)C1c1ccc2ccccc2c1 CHEMBL331799 Ki 4.9 nM
CN1Cc2cc(N3CCOCC3)ccc2C(c2ccc3sccc3c2)C1 CHEMBL3323182 IC50 4.9 nM
Cc1ccc2c(c1)CN(C)CC2c1ccc2sccc2c1 CHEMBL3323173 IC50 4.9 nM
Cc1noc(C)c1-c1ccc2c(c1)CNCC2c1ccc(Cl)c(Cl)c1 CHEMBL3703738 IC50 4.9 nM
CCCCCc1nc(C2CCN(CCCCc3c[nH]c4ccc(C#N)cc34)CC2)cn1-c1ccc(Oc2ccc(Cl)cc2)cc1 CHEMBL5181226 IC50 4.97 nM
CN(C)Cc1cc(N)ccc1Oc1ccc(Cl)c(Cl)c1 CHEMBL488911 IC50 4.99 nM
Oc1nc2cc3c(cc2c2c1[C@@H](N1CCC(Cc4cc(F)ccc4F)CC1)CCC2)OCO3 CHEMBL180899 IC50 5.0 nM
CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccc(S(=O)(=O)NCCO)cc21 CHEMBL381754 IC50 5.0 nM
CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccc(-n3ccnn3)cc21 CHEMBL439337 IC50 5.0 nM
CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccc(S(=O)(=O)NC)cc21 CHEMBL203776 IC50 5.0 nM
CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccc(C(=O)OC)cc21 CHEMBL380758 IC50 5.0 nM
CC(C)(O)CCN(Cc1ccc(F)cc1C(F)(F)F)C1CCNCC1 CHEMBL377552 Ki 5.0 nM
COc1ccc(Sc2ccccc2N)c(CN(C)C)c1 CHEMBL241648 Ki 5.0 nM
Cc1cccc(CN(C2CCOCC2)[C@H]2CCNC2)c1Cl CHEMBL247340 IC50 5.0 nM
Clc1cccc(CN(Cc2ccccn2)[C@H]2CCNC2)c1Cl CHEMBL391806 IC50 5.0 nM
c1cc([C@@H]2CN3CCC[C@@H]3c3cc(OCCCN4CCOCC4)ccc32)cs1 CHEMBL439389 Ki 5.0 nM
CNCc1cc(C(=O)N2CCN(C3CC3)CC2)ccc1Oc1ccc(SC)cc1 CHEMBL270165 Ki 5.0 nM
CNCc1cc(C(=O)N2CCCN(C(C)C)CC2)ccc1Oc1ccc(SC)cc1 CHEMBL267267 Ki 5.0 nM
CNCc1cc(C#N)ccc1Oc1ccc(Cl)cc1OC CHEMBL401878 IC50 5.0 nM
CC(C)CN(Cc1ccc2ccccc2c1)[C@@H]1CCNC1 CHEMBL471855 IC50 5.0 nM
COCC(Oc1ccc2ccccc2c1)C1CCNCC1 CHEMBL471035 IC50 5.0 nM
CSc1ccc(Sc2ccc(N(C)S(C)(=O)=O)cc2CN(C)C)cc1 CHEMBL479783 IC50 5.0 nM
CN(C)Cc1cc(NS(C)(=O)=O)ccc1Oc1ccc(C(F)(F)F)cc1 CHEMBL479410 IC50 5.0 nM
CSc1ccc(Cc2ccccc2CN(C)C)cc1 CHEMBL492842 IC50 5.0 nM
CN(C)Cc1ccccc1Cc1ccc(Cl)c(Cl)c1 CHEMBL491268 IC50 5.0 nM
CSc1ccc(Oc2ccc(C)cc2CN(C)C)cc1 CHEMBL490204 IC50 5.0 nM
CSc1ccc(Oc2ccncc2CN(C)C)cc1Cl CHEMBL491393 IC50 5.0 nM
CSc1ccc(Oc2ccc(NS(C)(=O)=O)cc2CN(C)C)cc1 CHEMBL450067 IC50 5.0 nM
CNCc1cc(S(=O)(=O)N(C)CCO)ccc1Oc1ccc(SC)cc1 CHEMBL522584 IC50 5.0 nM
CSc1ccc(Oc2ccc(S(N)(=O)=O)cc2CN(C)C)cc1C CHEMBL522625 IC50 5.0 nM
CC(C)C(=O)N(Cc1cccc(Cl)c1Cl)[C@@H]1CCNC1 CHEMBL450813 IC50 5.0 nM
CC(C)C(=O)N(Cc1ccc(Cl)c(Cl)c1Cl)[C@H]1CCNC1 CHEMBL477374 IC50 5.0 nM
CNC[C@]1(O)Cc2ccccc2[C@@H]1Oc1ccc(C)cc1C CHEMBL512044 IC50 5.0 nM
CCc1ccc(OC(c2cccnc2)C2CCNCC2)cc1 CHEMBL562444 IC50 5.0 nM
Clc1ccc(OC(c2cccnc2)C2CCNCC2)c(Cl)c1 CHEMBL540978 IC50 5.0 nM
CC(C)CN(C(=O)c1ccc2ccccc2c1)[C@@H]1CCNC1 CHEMBL577283 IC50 5.0 nM
O=C1NCc2ccc3c(c21)CC(N(CCCc1c[nH]c2ccc(F)cc12)CC1CC1)CO3 CHEMBL607419 Ki 5.0 nM
CS(=O)(=O)Nc1cc(OCCN2CC3CCC(C2)C3Cc2ccc3c(c2)NC(=O)CC3)ccc1F CHEMBL1087585 Ki 5.0 nM
CCCc1nc(C(=O)NCCCN2CCN(c3cccc(C)c3C)CC2)c(C)n1-c1ccccc1 CHEMBL3216085 IC50 5.0 nM
CCCc1nc(C(=O)NCCCN2CCN(c3cccc(C)c3C)CC2)c(C)n1-c1ccc2c(c1)OCCO2 CHEMBL3216518 IC50 5.0 nM
Cc1cccc(N2CCN(CC(O)CNC(=O)c3nc(C)n(-c4ccccc4)c3C)CC2)c1C CHEMBL3216299 IC50 5.0 nM
Cc1cccc(N2CCN(CC(O)CNC(=O)c3nc(C)n(-c4ccccc4Cl)c3C)CC2)c1C CHEMBL3215626 IC50 5.0 nM
Cc1cccc(CN(C2CCOCC2)C2CCNC2)c1Cl CHEMBL3818959 IC50 5.0 nM
Oc1ccc(-c2ccc3c(c2)CN2CCC3(c3ccc(Cl)c(Cl)c3)CC2)nn1 CHEMBL3673163 IC50 5.0 nM
Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1 CHEMBL4065568 Ki 5.0 nM
Fc1cc2c(c(OCCNCCc3c[nH]c4ccc(F)cc34)c1)OCCC2 CHEMBL340873 Ki 5.0 nM
CNCCC(Oc1ccc(Cl)c(Cl)c1)c1ccccc1 CHEMBL4869180 Ki 5.0 nM
Cc1ccc2c(N3CCN(CCc4ccc5c(c4F)NC(=O)CO5)CC3)cccc2n1 CHEMBL496520 pKi 5.012 nM
Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)[C@H](C)C3)cccc2n1 CHEMBL511815 pKi 5.012 nM
CC(C)CC1CNCCN1c1ccc2[nH]ncc2c1 CHEMBL1172526 pKi 5.012 nM
COC[C@@]12CNC[C@H](F)[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1173519 pKi 5.012 nM
CC(C)(C)CCC1(C(=O)c2cc(Cl)c(Cl)s2)CCNC1 CHEMBL1224241 pKi 5.012 nM
CC(C)(C)CCC1(C(=O)c2ccc3[nH]ncc3c2)CCCN1 CHEMBL1224094 pKi 5.012 nM
Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NCC6CC6)ncn4-5)CC3)cccc2n1 CHEMBL1242345 pKi 5.012 nM
N#Cc1ccnn1C[C@@]12CNCC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1818458 pKi 5.012 nM
Fc1cc(F)c(F)c(O[C@H](c2ccccc2)[C@@H]2CCNC2)c1F CHEMBL2338053 pIC50 5.012 nM
Fc1ccc(F)c(O[C@H](c2ccccc2)[C@H]2CCNC2)c1Cl CHEMBL2338050 pIC50 5.012 nM
Clc1ccc([C@@H]2CCNC[C@@]23CCOC3)cc1Cl CHEMBL4227955 pKi 5.012 nM
Cc1cccc(N2CCN(C[C@@H](O)CNC(=O)c3nc(C)n(-c4ccccc4)c3C)CC2)c1C CHEMBL3216958 IC50 5.08 nM
Cc1cccc(N2CCN(C[C@@H](O)CNC(=O)c3nc(C)n(-c4ccccc4)c3C)CC2)c1C CHEMBL1852374 IC50 5.08 nM
CNCc1ccc(Br)cc1Oc1ccc(Cl)c(Cl)c1 CHEMBL451137 IC50 5.1 nM
CN(C)C1CCC(c2c[nH]c3cc(F)ccc23)C1 CHEMBL1276226 IC50 5.1 nM
O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc2ccccc12 CHEMBL4096479 Ki 5.1 nM
CC[C@H]1C[C@@H]2C[C@H]3c4c(c5cc(C#N)ccc5n4C)CCN(C2)[C@@H]13 CHEMBL5188930 IC50 5.1 nM
CC(=O)N(Cc1ccc2ccccc2c1)[C@@H]1CCNC1 CHEMBL577497 IC50 5.2 nM
COC(=O)C(c1ccc(Cl)c(Cl)c1)C1CCNCC1 CHEMBL2407322 IC50 5.2 nM
Clc1ccccc1CN(CC1CNC1)c1ccccc1 CHEMBL3331508 IC50 5.2 nM
CC1NOC(C)C1c1ccc2c(c1)CN(C)CC2c1ccc2ccccc2c1 CHEMBL3954574 Ki 5.2 nM
Clc1ccc(C23CCN(Cc4cc(-c5ccc6ncnn6c5)ccc42)C3)cc1 CHEMBL3673129 IC50 5.2 nM
Clc1ccc(C23CCN(CC2)Cc2cc(-c4cnc5ccccc5n4)ccc23)cc1 CHEMBL3673146 IC50 5.2 nM
O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc2ccccc2c1 CHEMBL4074195 Ki 5.2 nM
COCCOc1cc(CC2CCN(CCc3ccc4c(c3)C(=O)CCO4)CC2)ccc1C CHEMBL4228775 Ki 5.25 nM
COc1ccc(C2CN(C)Cc3cc(OCCCN4CCN(c5nccs5)CC4)ccc32)cc1 CHEMBL396981 Ki 5.3 nM
COc1ccc(C2CN(C)Cc3cc(OCCCN4CCC(C#N)CC4)ccc32)cc1 CHEMBL394801 Ki 5.3 nM
CN(C)C1CC=C(c2c[nH]c3ccc(Br)cc23)CC1 CHEMBL396540 IC50 5.3 nM
CN(C)C1CCC(c2c[nH]c3cccc(Br)c23)C1 CHEMBL1276164 IC50 5.3 nM
CN(Cc1ccccc1)C1CCC(c2c[nH]c3ccc(C#N)cc23)C1 CHEMBL1276962 IC50 5.3 nM
O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1nc2ccccc2s1 CHEMBL1946258 Ki 5.3 nM
COc1ccc2c(c1)CN(C)CC2c1ccc2sccc2c1 CHEMBL3323174 IC50 5.3 nM
Clc1ccc(C23CCN(CC2)Cc2cc(-c4cnccn4)ccc23)cc1 CHEMBL3673143 IC50 5.3 nM
O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1 CHEMBL4088249 Ki 5.3 nM
COCCOc1cc(Br)cc(CC2CCN(CCc3ccc4c(c3)C(=O)CCO4)CC2)c1 CHEMBL4228218 Ki 5.32 nM
COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccc(F)cc4F)CC3)[C@@H]1CO2 CHEMBL328631 Ki 5.4 nM
Clc1ccccc1CC(c1ccccc1)N1CCNCC1 CHEMBL213287 IC50 5.4 nM
Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1 CHEMBL4060649 Ki 5.4 nM
COCCOc1cc(CC2CCN(CCc3ccc4c(c3)OCCC4)CC2)ccc1Br CHEMBL4225176 Ki 5.4 nM
COCCOc1cc(CC2CCN(CCc3cc4c(cc3Cl)OCCO4)CC2)ccc1Br CHEMBL4228034 Ki 5.47 nM
CCOc1ccc(C2(CC(C)CCNCCCC(N)=O)CCC2)cc1 CHEMBL3704756 Ki 5.49 nM
CN1C[C@H]2CCCC[C@@]2(Cc2ccc(Cl)c(Cl)c2)C1 CHEMBL1813487 pIC50 5.495 nM
OC1(c2ccc(Cl)cc2)c2ccc3ccccc3c2C2=NCCCN21 CHEMBL334577 Ki 5.5 nM
COc1cc2nc(O)c3c(c2cc1OC)CCC[C@@H]3N1CCC(Cc2cc(F)ccc2F)CC1 CHEMBL184571 IC50 5.5 nM
COc1ccc([C@H]2C[C@H]3CC[C@H]([C@H]2C(=O)OCCc2ccc(NC(C)=O)cc2)N3C)cc1 CHEMBL457655 Ki 5.5 nM
C=CCN1C2CCC1[C@@H](C(=O)OC)[C@@H](c1ccc(SC)cc1)C2 CHEMBL578219 Ki 5.5 nM
CNC[C@@H](O)[C@H](c1cccc(F)c1)N1CCc2cc(C)ccc21 CHEMBL597968 IC50 5.5 nM
CCc1cc(Oc2ccc(F)cc2CNC)ccc1Cl CHEMBL507721 IC50 5.53 nM
COC(=O)C1C(c2ccc3ccccc3c2)CC2C[C@@H](O)C1N2C CHEMBL86654 IC50 5.57 nM
CN(C)C[C@@H](c1ccc2ccccc2c1)[C@@H](O)c1ccccc1 CHEMBL539050 Kd 5.59 nM
COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccc(F)cc4)CC3)[C@@H]1CO2 CHEMBL419894 Ki 5.6 nM
CC(C)N(Cc1ccccc1C(F)(F)F)C1CCNCC1 CHEMBL377057 Ki 5.6 nM
CN1CCC(COCc2cc(C(F)(F)F)cc(C3(F)CC3)n2)(c2ccc(F)cc2)CC1 CHEMBL2333608 IC50 5.6 nM
COC(=O)/C=C1/CN2C3CCC2C1C(c1ccc(Br)cc1)C3 CHEMBL383873 Ki 5.63 nM
Cc1ccc(OC(c2ccc(Cl)c(Cl)c2)C2CNC2)cc1 CHEMBL3963829 IC50 5.67 nM
COCC(=O)Oc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1 CHEMBL175853 Ki 5.7 nM
CN(C)C[C@H]1C[C@H]1c1c[nH]c2ccc(C#N)cc12 CHEMBL373211 Ki 5.7 nM
N#Cc1ccc2c(N3CCN(CC[C@@H]4OCCc5cc(C(N)=O)ccc54)CC3)cccc2c1 CHEMBL391273 Ki 5.7 nM
COc1ccc(C2CN(C)Cc3cc(OCCCN4CCC(F)CC4)ccc32)cc1Cl CHEMBL246331 Ki 5.7 nM
CCCN1C2CCC1[C@@H](C(=O)OC)[C@@H](c1ccc(SC)cc1)C2 CHEMBL573361 Ki 5.7 nM
CN1CCc2ccccc2C1CCc1c[nH]c2ccc(F)cc12 CHEMBL598042 IC50 5.7 nM
COC[C@@H](c1ccc(Cl)c(Cl)c1)C1CCNCC1 CHEMBL2407333 IC50 5.7 nM
CCOc1ccc(C2(C(CC(C)C)NCCOC(=O)CC)CCC2)cc1 CHEMBL3704749 Ki 5.7 nM
O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1 CHEMBL4095979 Ki 5.7 nM
CNCc1cc(Cl)ccc1Oc1ccc(Cl)c(Cl)c1 CHEMBL505091 IC50 5.73 nM
CN(C)C[C@@H]1C2CCC(C2)[C@H]1c1ccc2ccccc2c1 CHEMBL109517 Ki 5.8 nM
CC(C)CN(Cc1ccc(C(F)(F)F)cc1F)C1CCNCC1 CHEMBL208232 Ki 5.8 nM
COC(=O)C1C(c2ccc(Cl)cc2)CC2CCC1N2C CHEMBL306208 IC50 5.87 nM
COC(=O)[C@@H]1C2CCC(C[C@H]1c1ccc(I)cc1)N2C CHEMBL375889 Ki 5.9 nM
CNCc1cc(C#CCCN(C)C2CC2)ccc1Oc1ccc(Cl)c(Cl)c1 CHEMBL237513 Ki 5.9 nM
CN(C)CC1CC1c1ccc2cc(C#N)c(C#N)cc2c1 CHEMBL401417 IC50 5.9 nM
CNCc1cc(C(=O)N2CCN(C(C)C)CC2)ccc1Oc1ccc(SC)cc1 CHEMBL270625 Ki 5.9 nM
c1ccc2cc(COC3CCNCC3)ccc2c1 CHEMBL471036 IC50 5.9 nM
CN(C)[C@H]1CC[C@H](c2c[nH]c3ccc(F)cc23)C1 CHEMBL1275792 IC50 5.9 nM
FC(F)Oc1ccc(-c2ccc3c(c2)CN2CCC3(c3ccc(Cl)cc3)C2)nn1 CHEMBL3673132 IC50 5.9 nM
Nc1cnc(-c2ccc3c(c2)CN2CCC3(c3ccc(Cl)c(Cl)c3)CC2)cn1 CHEMBL3673164 IC50 5.9 nM
COC(=O)[C@H]1C(c2ccc3ccccc3c2)CC2CCC1N2C CHEMBL318138 IC50 5.95 nM
Cc1ccc(-n2c(C)nc(C(=O)NCCCN3CCN(c4cccc(C)c4C)CC3)c2C)cc1 CHEMBL3681369 IC50 5.95 nM
CN(C)C(=O)Oc1ccc2c(c1)C=CCN(C)[C@@H]2CCOc1ccc([N+](=O)[O-])cc1 CHEMBL197696 IC50 6.0 nM
CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2cc(S(N)(=O)=O)ccc21 CHEMBL204285 IC50 6.0 nM
CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccc(O)cc21 CHEMBL206649 IC50 6.0 nM
CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccc(S(C)(=O)=O)cc21 CHEMBL206211 IC50 6.0 nM
COC(=O)[C@H]1C2CCC(C[C@@H]1c1ccc(I)cc1)N2C CHEMBL2096860 Ki 6.0 nM
Clc1cccc(CN(CC2CC2)[C@H]2CCNC2)c1Cl CHEMBL246920 IC50 6.0 nM
c1csc([C@@H]2CN3CCC[C@@H]3c3cc(OCCCN4CCOCC4)ccc32)c1 CHEMBL246927 Ki 6.0 nM
COc1cc(Cl)ccc1Oc1ccccc1CN(C)C CHEMBL404258 IC50 6.0 nM
CN(C)Cc1ccccc1Oc1ccc(Cl)cc1F CHEMBL256819 IC50 6.0 nM
Cc1cc(Oc2ccc(Cl)cc2C)c(CN(C)C)cn1 CHEMBL256970 IC50 6.0 nM
CNCc1cnc(C)cc1Oc1ccc(Cl)cc1C CHEMBL256137 IC50 6.0 nM
COc1cc(Cl)ccc1Oc1ccncc1CN(C)C CHEMBL257593 IC50 6.0 nM
c1ccc(CC2(c3ccc4[nH]ccc4c3)CCNC2)cc1 CHEMBL487355 Ki 6.0 nM
CNCc1cc(S(N)(=O)=O)ccc1Cc1ccc(Cl)c(Cl)c1 CHEMBL481306 IC50 6.0 nM
COc1ccc(Oc2ccc(SC)cc2)c(CN(C)C)c1 CHEMBL490205 IC50 6.0 nM
CNC[C@]1(O)Cc2ccccc2[C@@H]1Oc1ccc(F)cc1C CHEMBL506137 IC50 6.0 nM
Clc1cccc(OC(c2ccccn2)C2CCNCC2)c1Cl CHEMBL552046 IC50 6.0 nM
CC(C)CN(C(=O)c1cccc(Cl)c1Cl)[C@H]1CCNC1 CHEMBL1080787 Ki 6.0 nM
O=C(c1cccc(Cl)c1Cl)N(C1CCCC1)[C@H]1CCNC1 CHEMBL1080968 Ki 6.0 nM
O=C(c1cccc(Cl)c1Cl)N(C1=CCOC=C1)[C@H]1CCNC1 CHEMBL1079263 Ki 6.0 nM
CC(C)CN(C(=O)c1cc(Cl)cc(Cl)c1)[C@H]1CCNC1 CHEMBL1078741 Ki 6.0 nM
FC(F)Oc1ccccc1CC(c1ccccc1)N1CCNCC1 CHEMBL1083708 Ki 6.0 nM
CN[C@H]1Cc2ccccc2[C@H](c2ccc(Cl)c(Cl)c2)C1 CHEMBL1642894 IC50 6.0 nM
CNC(C)C1(c2ccc3ccccc3c2)CCCCC1 CHEMBL1684056 IC50 6.0 nM
Cc1cccc(N2CCN(CCCNC(=O)c3nc(C)n(-c4ccccc4)c3C)CC2)c1C CHEMBL3217176 IC50 6.0 nM
CCCc1nc(C(=O)NCC(O)CN2CCN(c3cccc(C)c3C)CC2)c(C)n1-c1ccc(OC)cc1 CHEMBL3216967 IC50 6.0 nM
CN(C)C[C@@H]1C[C@H]1c1ccc2[nH]cc(C#N)c2c1 CHEMBL2380983 IC50 6.0 nM
CCCc1nc(C(=O)NCC(O)CN2CCN(c3cccc(C)c3C)CC2)c(C)n1-c1ccc(OC)cc1 CHEMBL1852362 IC50 6.0 nM
O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1 CHEMBL4085802 Ki 6.0 nM
CN(C)C[C@H](c1ccc2ccccc2c1)[C@H](O)C1CCCCC1 CHEMBL4226233 Ki 6.0 nM
COc1ccc([C@@H](CN(C)C)C2(O)CCCCC2)cc1 CHEMBL252720 IC50 6.0 nM
CCN(C)C(=O)Oc1ccc2c(c1)C=CC(C)N(C)C2CCOc1ccc([N+](=O)[O-])cc1 CHEMBL5265846 IC50 6.0 nM
Cc1cccc(N2CCN(CCCNC(=O)c3nc(C)n(-c4ccc5c(c4)OCCO5)c3C)CC2)c1C CHEMBL3215864 IC50 6.08 nM
CC(C)(C)[C@H](O)[C@@H](CN)c1ccc2ccccc2c1 CHEMBL545557 Kd 6.1 nM
O=c1cccnn1-c1ccc2c(c1)CNCC2c1ccc(Cl)c(Cl)c1 CHEMBL3703736 IC50 6.1 nM
Clc1ccc(C23CCN(CC2)Cc2cc(Oc4cnccn4)ccc23)cc1 CHEMBL3673155 IC50 6.1 nM
O=S(=O)(NCCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(Cl)cc1 CHEMBL4070715 Ki 6.1 nM
N#Cc1ccc2[nH]cc([C@H]3CC[C@@H](N4CCc5cc(OCCCF)ccc5C4)CC3)c2c1 CHEMBL449277 Ki 6.16 nM
Cc1c(Cl)cccc1N1CCN(CCCNC(=O)c2nc(C)n(-c3ccccc3F)c2C)CC1 CHEMBL3216503 IC50 6.17 nM
Cc1c(Cl)cccc1N1CCN(CCCNC(=O)c2nc(C)n(-c3ccccc3F)c2C)CC1 CHEMBL1852552 IC50 6.17 nM
NC[C@@H](c1ccc2ccccc2c1)[C@@H](O)c1ccccc1 CHEMBL539564 Kd 6.2 nM
CNC(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 CHEMBL1627 Ki 6.2 nM
CCN(CC)C1CCC(c2c[nH]c3ccc(C#N)cc23)C1 CHEMBL1276961 IC50 6.2 nM
CN(CCc1ccccc1)C1CCC(c2c[nH]c3ccc(C#N)cc23)C1 CHEMBL1277048 IC50 6.2 nM
COC(=O)[C@H]1[C@@H](c2ccc(Cl)c(C)c2)C[C@@H]2CC[C@H]1N2 CHEMBL1812746 IC50 6.2 nM
CCCc1nc(C(=O)NCC(O)CN2CCN(c3cccc(Cl)c3C)CC2)c(C)n1-c1ccccc1 CHEMBL3216756 IC50 6.2 nM
Nc1nc(NC[C@H]2CC[C@H](CNS(=O)(=O)c3ccc4ccccc4c3)CC2)nc2ccccc12 CHEMBL1836102 Ki 6.2 nM
c1ccc2cc(CN(C3CCCCC3)C3CNC3)ccc2c1 CHEMBL3331468 IC50 6.2 nM
Clc1ccc(C2CNCc3cc(-c4cccnn4)ccc32)cc1Cl CHEMBL3703743 IC50 6.2 nM
Cc1cccc(S(=O)(=O)NCCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1 CHEMBL4077040 Ki 6.2 nM
CNCc1ccc(Cl)cc1Oc1ccc(Cl)c(Cl)c1 CHEMBL488261 IC50 6.22 nM
Fc1ccc2[nH]cc(CCCNCCOc3cccc4c3OCCO4)c2c1 CHEMBL419240 IC50 6.3 nM
CNCc1cc(C(=O)N2CCN(C(C)C)CC2)ccc1Oc1ccc(Cl)c(Cl)c1 CHEMBL408206 Ki 6.3 nM
CCCc1nc(C(=O)NCC(O)CN2CCN(c3cccc(C)c3C)CC2)c(C)n1-c1ccc(F)cc1 CHEMBL2447952 IC50 6.3 nM
FC(F)(F)c1cc(Cl)cc(COCC2(c3ccccc3)CCNCC2)n1 CHEMBL2333648 IC50 6.3 nM
CN1CCC(COCc2cc(C(F)(F)F)cc(Cl)n2)(c2ccccc2)CC1 CHEMBL2333640 IC50 6.3 nM
Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1 CHEMBL183460 Log Ki 6.31 nM
Cc1cc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2[nH]1 CHEMBL444398 pKi 6.31 nM
NS(=O)(=O)c1cccc(CN(c2ccc3[nH]ccc3c2)C2CCNCC2)c1 CHEMBL552341 pKi 6.31 nM
c1ccc(CCN(c2ccc3[nH]ccc3c2)C2CCNCC2)cc1 CHEMBL564288 pKi 6.31 nM
c1ccc(CN(c2ccc3[nH]ccc3c2)C2CCCNC2)cc1 CHEMBL560536 pKi 6.31 nM
CCC[C@@H]1CNCCN1c1ccc2[nH]ncc2c1 CHEMBL1172524 pKi 6.31 nM
FC(F)(F)COC[C@@]12CNCC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1173594 pKi 6.31 nM
O=C(c1ccc2[nH]ccc2c1)C1(Cc2ccccc2)CCNC1 CHEMBL1224562 pKi 6.31 nM
CC(C)(C)CCC1(C(=O)c2cc3ccccc3[nH]2)CCNC1 CHEMBL1224238 pKi 6.31 nM
CCCC1(C(=O)c2cc(F)c3[nH]ccc3c2)CCCN1 CHEMBL1224165 pKi 6.31 nM
Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)N6CCC6)ncn4-5)CC3)cccc2n1 CHEMBL1242436 pKi 6.31 nM
Cc1cnc([C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)o1 CHEMBL1818443 pKi 6.31 nM
Clc1cc(Cl)cc(O[C@@H](c2ccccc2)[C@H]2CCNC2)c1 CHEMBL2337607 pIC50 6.31 nM
Cc1cc(Cl)cc(-c2ccccn2)c1O[C@@H](c1ccccc1)[C@H]1CCNC1 CHEMBL2338054 pIC50 6.31 nM
Fc1ccc(F)c(O[C@@H](c2ccccc2)[C@@H]2CCNC2)c1Cl CHEMBL2338051 pIC50 6.31 nM
CNCCC(Oc1cccc2ccccc12)c1nccs1 CHEMBL138031 Ki 6.4 nM
CNCc1cc(C(=O)N2CCCN(C(C)C)CC2)ccc1Oc1ccc(Cl)cc1 CHEMBL272077 Ki 6.4 nM
CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCC4CC43)n2)(c2ccc(F)cc2)CC1 CHEMBL2333625 IC50 6.4 nM
CN1Cc2ccccc2C(c2ccc3cc[nH]c3c2)C1 CHEMBL3323102 IC50 6.4 nM
Oc1ccc(-c2ccc3c(c2)CN2CCC3(c3ccc(Cl)cc3)C2)nn1 CHEMBL3673133 IC50 6.4 nM
Cc1nnc(-c2ccc3c(c2)CN2CCC3(c3ccc(Cl)cc3)CC2)s1 CHEMBL3673150 IC50 6.4 nM
Fc1ccc(C23CCN(CC2)Cc2cc(Oc4ccc(C(F)(F)F)nn4)ccc23)cc1Cl CHEMBL3673169 IC50 6.4 nM
N#Cc1ccc2[nH]cc(CCCCN3CCC(c4cn(-c5ccc(Oc6ccc(Cl)cc6)cc5)c(C5CC5)n4)CC3)c2c1 CHEMBL5184959 IC50 6.42 nM
[11CH3]Oc1cccc2c1CCN(CCCc1c[nH]c3ccc(F)cc13)C2 CHEMBL520301 Ki 6.46 nM
CN(C)C[C@H]1C[C@@H]1c1cn(C)c2ccc(C#N)cc12 CHEMBL199053 Ki 6.5 nM
COc1ccc(C2CN(C)Cc3cc(OCCCN4CCC(F)(F)CC4)ccc32)cc1 CHEMBL395096 Ki 6.5 nM
COc1ccc(C2CN(C)Cc3cc(OCCCN4CCOCC4)ccc32)cc1 CHEMBL233053 Ki 6.5 nM
CSc1ccc(C2CN(C)Cc3cc(Oc4ccc(CN5CCC(F)CC5)cn4)ccc32)cc1 CHEMBL238053 Ki 6.5 nM
CN(C)C1CCC(c2c[nH]c3cc(Cl)ccc23)C1 CHEMBL1276227 IC50 6.5 nM
N#Cc1ccc2[nH]cc(C3CCC(N4CCc5ccccc5C4)C3)c2c1 CHEMBL1277229 IC50 6.5 nM
CCCN1CCC(c2csc3ccccc23)CC1 CHEMBL2207487 Ki(app) 6.5 nM
CCN(CC)C(=O)C1(c2ccccc2)CC1CN CHEMBL259209 Ki 6.5 nM
O=C1CCOc2ccc(CCN3CCC(Cc4ccc(Br)c(O)c4)CC3)cc21 CHEMBL3656913 Ki 6.5 nM
CCNC1CCC(c2c[nH]c3ccc(C#N)cc23)C1 CHEMBL1276299 IC50 6.6 nM
CCCc1nc(C(=O)NCCCN2CCN(c3cccc(C)c3C)CC2)c(C)n1-c1ccc(F)cc1 CHEMBL3215618 IC50 6.6 nM
CN1CCC(COCc2cc(C(F)(F)F)cc(N3CCCC3)n2)(c2ccccc2)CC1 CHEMBL2333624 IC50 6.6 nM
Clc1cc(COCC2(c3ccccc3)CCNCC2)cc(Cl)n1 CHEMBL2333647 IC50 6.6 nM
CNCc1cc(C#CCCN2CCSCC2)ccc1Oc1ccc(Cl)c(Cl)c1 CHEMBL237319 Ki 6.7 nM
Cc1sc(C2CCN(CCCCc3c[nH]c4ccc(C#N)cc34)CC2)nc1-c1ccc(Oc2ccc(Cl)cc2)cc1 CHEMBL5170075 IC50 6.71 nM
CCC(CC)N(Cc1ccccc1C(F)(F)F)C1CCNCC1 CHEMBL383734 Ki 6.8 nM
CNCc1cc(C(=O)N2CCN(C3CC3)CC2)ccc1Oc1ccc(Cl)c(Cl)c1 CHEMBL402644 Ki 6.8 nM
NCC[C@@H](Oc1cccc2ccccc12)c1cccs1 CHEMBL594585 IC50 6.8 nM
N#Cc1ccc2[nH]cc(C3CCC(N4Cc5ccccc5C4)C3)c2c1 CHEMBL1277138 IC50 6.8 nM
CCCOC(c1ccc2ccccc2c1)C1CNC1 CHEMBL2171416 IC50 6.8 nM
CN1CCC(COCc2cc(C(F)(F)F)cc(C3CCCC3)n2)(c2ccc(F)cc2)CC1 CHEMBL2333610 IC50 6.8 nM
CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2ccccc2)CC1 CHEMBL2333604 IC50 6.8 nM
CCC(CC)CN(Cc1ccccc1C(F)(F)F)C1CCNCC1 CHEMBL378498 Ki 6.9 nM
Cc1cccc(N2CCN(CCCNC(=O)c3nc(C)n(-c4ccccc4F)c3C)CC2)c1C CHEMBL3216741 IC50 6.9 nM
CN1Cc2ccccc2C(c2ccc3ncccc3c2)C1 CHEMBL3323109 IC50 6.9 nM
O=c1ccccn1-c1ccc2c(c1)CNCC2c1ccc(Cl)c(Cl)c1 CHEMBL3703735 IC50 6.9 nM
CNCCC=C1c2ccccc2CCc2ccccc21 CHEMBL445 Ki 6.977 nM
CN(C)CCCc1c[nH]c2ccc(Cl)cc12 CHEMBL362170 IC50 7.0 nM
CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2cc(C(=O)N(C)C)ccc21 CHEMBL205505 IC50 7.0 nM
CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2cc([S+](C)[O-])ccc21 CHEMBL382241 IC50 7.0 nM
CNCc1cc(C(N)=O)ccc1Oc1ccc(Cl)cc1C CHEMBL401819 IC50 7.0 nM
CNCc1cc(C(=O)N(C)C)ccc1Oc1ccc(Cl)cc1OC CHEMBL402345 IC50 7.0 nM
CN1[C@H]2CC[C@@H]1[C@@H](C=C(Br)Br)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL494626 Ki 7.0 nM
c1ccc(CC2(c3ccc4sccc4c3)CCNC2)cc1 CHEMBL486537 Ki 7.0 nM
CN(C)Cc1ccccc1Oc1ccc(OC(F)(F)F)cc1 CHEMBL481353 IC50 7.0 nM
CN(C)Cc1cc(NS(C)(=O)=O)ccc1Oc1ccc2c(c1)CCS2 CHEMBL489562 IC50 7.0 nM
CCc1cccc(OC(c2cccnc2)C2CCNCC2)c1 CHEMBL551443 IC50 7.0 nM
CSc1ccc(OC(c2cccnc2)C2CCNCC2)cc1 CHEMBL564631 IC50 7.0 nM
Clc1ccc(Cl)c(OC(c2cccnc2)C2CCNCC2)c1 CHEMBL559654 IC50 7.0 nM
Clc1ccc(OC(c2ccccn2)C2CCNCC2)c(Cl)c1 CHEMBL562108 IC50 7.0 nM
Clc1ccc(OC(c2ccncc2)C2CCNCC2)c(Cl)c1 CHEMBL556888 IC50 7.0 nM
CNC[C@H]1CCC[C@@H]1c1c[nH]c2ccc(C#N)cc12 CHEMBL562118 IC50 7.0 nM
Cc1c(C(=O)N(C(C)C)[C@@H]2CCNC2)ccc(Cl)c1Cl CHEMBL567725 IC50 7.0 nM
N#Cc1ccc2[nH]cc(CCC3CCCCN3Cc3ccccc3)c2c1 CHEMBL600890 IC50 7.0 nM
Cc1ccc(Oc2cc(F)ccc2CN(C)C)c(N)c1 CHEMBL592697 Ki 7.0 nM
Cc1ccc(Oc2ccc(OCCCF)cc2CN(C)C)c(N)c1 CHEMBL589178 Ki 7.0 nM
CC(C)CN(C(=O)c1ccc(F)cc1Cl)[C@H]1CCNC1 CHEMBL1078076 Ki 7.0 nM
Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2cccnc2)n1C CHEMBL1212957 IC50 7.0 nM
CNCCC(c1ccccc1)c1ccc(O)c2ccc(OCCN3CCCC3)cc12 CHEMBL1277411 Ki 7.0 nM
CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(Cl)c(Cl)c2)C1 CHEMBL1642898 IC50 7.0 nM
CN(C)[C@@H]1CCN(c2ccc(Cl)c(Cl)c2)c2ccccc21 CHEMBL1643514 IC50 7.0 nM
CN(C)C[C@]1(c2ccc3ccccc3c2)CC[C@](C)(O)CC1 CHEMBL4227830 IC50 7.0 nM
CN(C)CCC=C1c2ccccc2C=Cc2ccccc21 CHEMBL669 AC50 7.0 nM
COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cccc(F)c4F)CC3)[C@@H]1CO2 CHEMBL419336 Ki 7.1 nM
S=P(N1CC1)(N1CC1)N1CC1 CHEMBL671 AC50 7.1 nM
Cc1cc2c(OC[C@@H](O)CN3CC[C@@H](c4cccc5occc45)C[C@@H]3C)cccc2[nH]1 CHEMBL2112352 Ki 7.18 nM
COc1ccc(C2CN(C)Cc3cc(OCCCN4CCN(c5ccccc5O)CC4)ccc32)cc1 CHEMBL242817 Ki 7.2 nM
CS(=O)(=O)c1ccc(-c2ccc3c(c2)CN2CCC3(c3ccc(Cl)cc3)CC2)cc1 CHEMBL3673151 IC50 7.2 nM
Fc1cc(C23CCN(CC2)Cc2cc(Oc4ccc(C(F)(F)F)nn4)ccc23)ccc1Cl CHEMBL3673170 IC50 7.2 nM
COc1ccc2c(c1)C=C[C@@H]1C2=NO[C@H]1CN1CCN(C/C=C/c2ccccc2)CC1 CHEMBL2112982 Ki 7.3 nM
COc1ccc(C2CN(C)Cc3cc(OCCCN4CCC(F)(F)C4)ccc32)cc1 CHEMBL234732 Ki 7.3 nM
CNCc1cc(C#CCCN2CCOCC2)ccc1Oc1cccc(Cl)c1 CHEMBL397575 Ki 7.3 nM
CN(C)CCC(Oc1ccc(Cl)c(Cl)c1)c1ccc(OCCCN2CCCCC2)cc1 CHEMBL2447963 Ki 7.3 nM
CCN(CC)C1CCC(c2c[nH]c3ccc(F)cc23)C1 CHEMBL1275707 IC50 7.3 nM
CCCc1nc(C(=O)NCCCN2CCN(c3cccc(C)c3C)CC2)c(C)n1-c1ccccc1Cl CHEMBL3216754 IC50 7.3 nM
CCN(CC)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 CHEMBL2333618 IC50 7.3 nM
CN(C)c1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCNCC2)n1 CHEMBL2333617 IC50 7.3 nM
Clc1ccc(C23CCN(CC2)Cc2cc(-c4cncnc4)ccc23)cc1 CHEMBL3673142 IC50 7.3 nM
O=c1ccccn1-c1ccc2c(c1)CN1CCC2(c2ccc(Cl)cc2)CC1 CHEMBL3673149 IC50 7.3 nM
CN(C)C[C@H]1C[C@@H]1c1c[nH]c2cc(C#N)ccc12 CHEMBL197966 Ki 7.4 nM
C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@H]1OCCc2cc(C(N)=O)ccc21 CHEMBL234448 Ki 7.4 nM
CN1C2CCC1[C@@H](CNc1cccc(Br)n1)[C@@H](c1ccc(Cl)cc1)C2 CHEMBL1914696 Ki 7.4 nM
FC(F)(F)c1cc(Cl)nc(COCC2(c3ccccc3)CCNCC2)c1 CHEMBL2333639 IC50 7.4 nM
CNC[C@H]1C[C@@]1(Oc1cccc2ccccc12)c1cccs1 CHEMBL558329 Ki 7.47 nM
N#Cc1ccc2[nH]cc(CCCCN3CCC(c4cn(-c5ccc(Oc6ccc(Cl)cc6)cc5)c(C5CCC5)n4)CC3)c2c1 CHEMBL5175011 IC50 7.47 nM
CNCc1cc(Cl)ccc1Oc1ccc(Cl)cc1 CHEMBL462226 IC50 7.49 nM
COC(=O)[C@H]1[C@@H](c2cc(I)c(OC)c(I)c2)C[C@H]2CC[C@H]1N2C CHEMBL457416 Ki 7.5 nM
CNCc1cc(F)ccc1Oc1ccc(C)c(C)c1 CHEMBL488021 IC50 7.55 nM
Cc1cccc(N2CCN(CC(O)CNC(=O)c3nc(C)n(-c4ccccc4F)c3C)CC2)c1C CHEMBL3216289 IC50 7.59 nM
CNCCC(Oc1cccc2ccccc12)c1cccc(Br)c1 CHEMBL337798 Ki 7.6 nM
COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccc(O)cc4)CC3)[C@@H]1CO2 CHEMBL329065 Ki 7.6 nM
CN1CC[C@H](Cc2ccccc2)C[C@@H]1CCc1c[nH]c2ccc(C#N)cc12 CHEMBL605535 IC50 7.6 nM
CC(C)N(Cc1ccc(Cl)c(Cl)c1)CC1CNC1 CHEMBL3331503 IC50 7.6 nM
CC(=O)Oc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1 CHEMBL176116 Ki 7.7 nM
C=C1CN2C3CCC2C1C(c1ccc(C)cc1)C3 CHEMBL377785 Ki 7.77 nM
CCCc1nc(C2CCN(CCCCc3c[nH]c4ccc(C#N)cc34)CC2)cn1-c1ccc(Oc2ccc(Cl)cc2)cc1 CHEMBL5208902 IC50 7.77 nM
COc1ccc2c(c1)CN1CCC2(c2ccc(Cl)cc2)CC1 CHEMBL3673138 IC50 7.8 nM
Clc1ccc(C(OCc2ccccc2)C2CNC2)cc1Cl CHEMBL2219958 IC50 7.81 nM
CN1C2CCC1C(C(=O)NCCCCCCCCNC(=O)C1C(c3ccc(Cl)cc3)CC3CCC1N3C)C(c1ccc(Cl)cc1)C2 CHEMBL307314 Ki 7.9 nM
Cc1ccc([C@H]2C[C@H]3CCC4C2[C@@](O)(c2ccccc2)CN43)cc1 CHEMBL321067 IC50 7.9 nM
CC(C)CN(Cc1cc(F)ccc1C(F)(F)F)C1CCNCC1 CHEMBL208252 Ki 7.9 nM
CSc1ccc(C2CN(C)Cc3cc(Oc4ccc(CN5CCOCC5)cn4)ccc32)cc1 CHEMBL237863 Ki 7.9 nM
Cc1ccc2c(N3CCN(CCc4cccc5c4OCC(=O)N5C)CC3)cc(F)cc2n1 CHEMBL469374 pKi 7.943 nM
Clc1ccc([C@@]23CNC[C@@H]2[C@H]3COC2CCCC2)cc1Cl CHEMBL596989 pKi 7.943 nM
NC(=O)c1cc2cc(N3CCNCC3Cc3ccccc3)ccc2[nH]1 CHEMBL1170017 pKi 7.943 nM
Cn1ccc2cc(N3CCNCC3Cc3ccccc3)ccc21 CHEMBL1170794 pKi 7.943 nM
COC[C@@]12CN[C@@H](C)C[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1173416 pKi 7.943 nM
OC[C@@]12CNCC[C@]1(c1ccc(Cl)c(Cl)c1)C2 CHEMBL1173530 pKi 7.943 nM
CCC[C@@]1(C(=O)c2ccc(Cl)c(Cl)c2)CCCN1 CHEMBL1224025 pKi 7.943 nM
O=C(c1ccc2[nH]ccc2c1)C1(Cc2ccccc2)CCNCC1 CHEMBL1224162 pKi 7.943 nM
Cc1ccc2c(N3CCN(CCc4cccc5c4OCc4c(C(=O)NC(C)C)ncn4-5)CC3)cccc2n1 CHEMBL1241998 pKi 7.943 nM
Cc1cc([C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)no1 CHEMBL1818446 pKi 7.943 nM
Cc1noc([C@@]23CNCC[C@]2(c2ccc(Cl)c(Cl)c2)C3)n1 CHEMBL1818447 pKi 7.943 nM
Fc1cc(F)c(Cl)c(O[C@@H](c2ccccc2)[C@H]2CCNC2)c1Cl CHEMBL2338045 pIC50 7.943 nM
Fc1ccc(O[C@@H](c2ccccc2)[C@H]2CCNC2)c(F)c1 CHEMBL2338031 pIC50 7.943 nM
Clc1ccc(O[C@@H](c2ccccc2)[C@H]2CCNC2)cc1 CHEMBL2337596 pIC50 7.943 nM
CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2cccc(C(N)=O)c21 CHEMBL205837 IC50 8.0 nM
CCN(Cc1ccccc1C(F)(F)F)C1CCNCC1 CHEMBL208069 Ki 8.0 nM
COc1ccc(C2CN(C)Cc3cc(OCCCN4CCN(c5ccc(C#N)cc5)CC4)ccc32)cc1 CHEMBL395022 Ki 8.0 nM
CSc1ccc(C2CN(C)Cc3cc(Oc4ccc(CN5CCCCC5)nc4)ccc32)cc1 CHEMBL400831 Ki 8.0 nM
Cc1cccc(CN(Cc2ccccn2)[C@H]2CCNC2)c1C CHEMBL245482 IC50 8.0 nM
CN(C)Cc1cnccc1Oc1ccc(Cl)cc1Cl CHEMBL260036 IC50 8.0 nM
c1ccc(CC2(c3ccc4cc[nH]c4c3)CCNC2)cc1 CHEMBL459165 Ki 8.0 nM
c1ccc2cc(OCC3CCNCC3)ccc2c1 CHEMBL453996 IC50 8.0 nM
CC1CN(c2ccc3ccccc3n2)CCN1CCCCN1C(=O)c2ccccc2C1=O CHEMBL485540 IC50 8.0 nM
CSc1ccc(Oc2ccncc2CN(C)C)cc1C CHEMBL489186 IC50 8.0 nM
Cc1ccnc(C(Oc2cccc(Cl)c2Cl)C2CCNCC2)c1 CHEMBL562691 IC50 8.0 nM
Clc1cccc(OC(c2ccncc2)C2CCNCC2)c1Cl CHEMBL550779 IC50 8.0 nM
Clc1cccc(OC(c2ccccc2)C2CCNCC2)c1Cl CHEMBL541226 IC50 8.0 nM
COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(c4ccccc4)(c4ccc(Cl)nc4)CC3)C(C)(C)C2)cc1 CHEMBL551206 IC50 8.0 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(SC(F)(F)F)cc1)N2C CHEMBL573844 Ki 8.0 nM
O=c1[nH]c2cccc(N3C[C@H]4C[C@@H]3CN4CC3CCc4[nH]c5ccc(F)cc5c4C3)c2o1 CHEMBL566356 Ki 8.0 nM
CC(C)N(CCCc1c[nH]c2ccc(F)cc12)C1COc2ccc3c(c2C1)C(=O)NCC3 CHEMBL592951 Ki 8.0 nM
O=C1NCc2ccc3c(c21)CC(NCCCc1c[nH]c2ccc(F)cc12)CO3 CHEMBL594829 Ki 8.0 nM
CCN(CCCc1c[nH]c2ccc(F)cc12)C1COc2ccc3c(c2C1)C(=O)NC3 CHEMBL592029 Ki 8.0 nM
Cc1ccc(Oc2ccc(F)cc2CN(C)C)c(N)c1 CHEMBL246388 Ki 8.0 nM
Oc1ccccc1C[C@H](c1ccccc1)N1CCNCC1 CHEMBL1084971 Ki 8.0 nM
c1ccc(C(Cc2cccc3c2OCC3)N2CCNCC2)cc1 CHEMBL1083707 Ki 8.0 nM
COc1ccccc1CC(c1cccc(F)c1)N1CCNCC1 CHEMBL1085321 Ki 8.0 nM
COc1ccccc1CC(c1ccc(F)cc1)N1CCNCC1 CHEMBL1085567 Ki 8.0 nM
CN[C@@H]1Cc2ccccc2[C@H](c2ccc(Cl)c(Cl)c2)C1 CHEMBL1642896 IC50 8.0 nM
NCCCCc1c[nH]c2c(F)cccc12 CHEMBL2347032 Ki 8.0 nM
Clc1ccc(C23CCN(CC2)Cc2cc(N4CCOCC4)ccc23)cc1 CHEMBL3673178 IC50 8.0 nM
CN(C)CCCC1(c2ccc(F)cc2)OCc2cc3ccccc3cc21 CHEMBL4064213 IC50 8.0 nM
CNC(C)c1cc(F)ccc1Oc1ccc(Cl)c(Cl)c1 CHEMBL488437 IC50 8.09 nM
NC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(c2ccc3cc(F)ccc3c2)CC1 CHEMBL234449 Ki 8.1 nM
CNCc1cc(C(=O)N2CCN(C(C)C)CC2)ccc1Oc1ccc(SC)c(C)c1 CHEMBL273157 Ki 8.1 nM
CN1CCCC1CCc1c[nH]c2ccc(C#N)cc12 CHEMBL600263 IC50 8.1 nM
CC(C)CC(NCCCC(N)=O)C1(c2ccc(Cl)c(Cl)c2)CCC1 CHEMBL3946788 Ki 8.1 nM
Clc1ccc(Cl)c(CC(c2ccccc2)N2CCNCC2)c1 CHEMBL377900 IC50 8.2 nM
COc1ccc(C2CN(C)Cc3cc(OCCCN4CCCC(F)(F)C4)ccc32)cc1 CHEMBL233470 Ki 8.2 nM
CC(C)c1sc(C2CCN(CCCCc3c[nH]c4ccc(C#N)cc34)CC2)nc1-c1ccc(Oc2ccc(Cl)cc2)cc1 CHEMBL5183093 IC50 8.23 nM
N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6cc[nH]c6)CC5)cc4)CC3)c2c1 CHEMBL5080984 IC50 8.25 nM
CSc1ccc(C2CN(C)Cc3cc(Oc4cncc(CN5CCCCC5)c4)ccc32)cc1 CHEMBL236783 Ki 8.3 nM
CN(C)CCC(Oc1ccc(C(F)(F)F)cc1)c1ccccc1 CHEMBL198298 Ki 8.3 nM
c1cncc([C@@H]2CN3CCC[C@@H]3c3cc(OCCCN4CCCCC4)ccc32)c1 CHEMBL247933 Ki 8.3 nM
NCC1CC1(C(=O)C1NCCc2ccccc21)c1ccccc1 CHEMBL256667 IC50 8.3 nM
COc1ccc([C@H]2C[C@H]3CC[C@H]([C@H]2C(=O)OCCc2ccc(N)cc2)N3C)cc1 CHEMBL458080 Ki 8.3 nM
c1ccc(OC(c2ccc3ccccc3c2)C2CNC2)cc1 CHEMBL2171417 IC50 8.3 nM
CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2cccc(F)c2)CC1 CHEMBL2333615 IC50 8.3 nM
CC(C)CN(Cc1ccccc1)C1CCNCC1 CHEMBL207837 Ki 8.4 nM
CN1Cc2cc(F)ccc2C(c2ccc3sccc3c2)C1 CHEMBL3323176 IC50 8.4 nM
c1ccc(N(Cc2ccc3ccccc3c2)CC2CNC2)cc1 CHEMBL3331485 IC50 8.4 nM
COc1cc(NC(C)CCCN)c2ncccc2c1 CHEMBL506 Ki 8.405 nM
N#Cc1ccc2[nH]cc(CCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6cc[nH]c6)CC5)cc4)CC3)c2c1 CHEMBL5075438 IC50 8.41 nM
COCCOc1cc(CC2CCN(CCc3ccc4c(c3)C(O)CCO4)CC2)ccc1Br CHEMBL4229188 Ki 8.44 nM
Cc1cc(C)c([C@H](O)[C@@H](CN(C)C)c2ccccc2)c(C)c1 CHEMBL544633 Kd 8.5 nM
COc1cccc2c1O[C@@H](CN1C3C=C(n4ccc5cc(F)ccc54)CC1CC3)CO2 CHEMBL150050 Ki 8.5 nM
COC(=O)[C@@H]1C2CCC(C[C@@H]1c1ccc(Br)cc1)N2C/C=C/CF CHEMBL1214007 Ki 8.5 nM
CNC1CCC(c2c[nH]c3ccc(C#N)cc23)C1 CHEMBL1276298 IC50 8.5 nM
Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c[nH]c4ccc(F)cc34)CC2)c1 CHEMBL4078873 Ki 8.5 nM
CN1Cc2cc(OCCCN3CCC(F)CC3)ccc2C(c2ccc(C(F)(F)F)cc2)C1 CHEMBL246542 Ki 8.6 nM
CN(C)CC1CC1c1ccc2ccccc2c1 CHEMBL249951 IC50 8.6 nM
Clc1ccc(C23CCN(CC2)Cc2cc(-c4ccc5ncnn5c4)ccc23)cc1Cl CHEMBL3673159 IC50 8.6 nM
O=C(CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1ccc(F)cc1 CHEMBL267930 AC50 8.6 nM
CN(C)CCC(Oc1ccc([N+](=O)[O-])cc1)c1ccc(OCCCN2CCCCC2)cc1 CHEMBL246125 Ki 8.7 nM
CNCc1ccc(OC)cc1Oc1ccc(Cl)c(Cl)c1 CHEMBL500329 IC50 8.72 nM
COc1ccc(C2CN(C)Cc3cc(OCCCN4CCN(C(=O)c5cccn5C)CC4)ccc32)cc1 CHEMBL232218 Ki 8.8 nM
C[C@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@H]1OCc2cc(C(N)=O)ccc21 CHEMBL3706924 Ki 8.8 nM
CN1Cc2ccccc2C(c2cc3ccccc3s2)C1 CHEMBL3323097 Ki 8.8 nM
Cc1cc2c(cc1OCCCCN1CCN(c3cccc4cc(F)ccc34)CC1)C(=O)NC2 CHEMBL1258087 Ki 8.81 nM
N#Cc1ccc2[nH]cc(CCN3CCN(c4ccc5c(c4)CC(CC4CCN(Cc6ccccc6)CC4)C5=O)CC3)c2c1 CHEMBL5076406 IC50 8.81 nM
CNCC[C@@H](Oc1ccccc1C)c1ccccc1 CHEMBL641 Kd 8.9 nM
COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CN2 CHEMBL2112985 Ki 8.9 nM
CN(C)C[C@@H]1C[C@H]1c1c[nH]c2ccc(C#N)cc12 CHEMBL195774 Ki 8.9 nM
COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CN2 CHEMBL390718 Ki 8.9 nM
CNCc1cc(C)c(C)cc1Oc1ccc(Cl)c(Cl)c1 CHEMBL455425 IC50 8.9 nM
CC(C)Cc1cc(C(F)(F)F)cc(COCC2(c3ccc(F)cc3)CCN(C)CC2)n1 CHEMBL2333634 IC50 8.9 nM
Cc1cccc(CN(C2CCOCC2)C2CCNC2)c1C CHEMBL3817970 IC50 8.9 nM
Fc1ccc(C23CCN(CC2)Cc2cc(Oc4ccc(C(F)(F)F)nn4)ccc23)cc1 CHEMBL3673173 IC50 8.9 nM
CN1C[C@@H]2CCC[C@]2(c2ccc(Cl)c(Cl)c2)C1 CHEMBL1813478 pIC50 8.913 nM
CCOc1ccccc1OC(c1ccccc1)C1CNCCO1 CHEMBL14370 Ki 9.0 nM
CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccc(C(=O)N(C)C)cc21 CHEMBL380523 IC50 9.0 nM
Cc1cccc(CN(C2CCOCC2)[C@H]2CCNC2)c1C CHEMBL247733 IC50 9.0 nM
CN(C)CCC(Oc1ccc(Br)cc1)c1ccc(OCCCN2CCCCC2)cc1 CHEMBL391193 Ki 9.0 nM
CNCc1cc(C(=O)N2CCCN(C3CC3)CC2)ccc1Oc1ccc(Cl)c(Cl)c1 CHEMBL257738 Ki 9.0 nM
CNCCC(c1ccccc1)c1c[nH]c2ccccc12 CHEMBL487763 Ki 9.0 nM
CN(C)Cc1cc(S(N)(=O)=O)ccc1Oc1ccc(OC(F)(F)F)cc1 CHEMBL479409 IC50 9.0 nM
CNS(=O)(=O)c1ccc(Oc2ccc(SC)cc2)c(CN(C)C)c1 CHEMBL489166 IC50 9.0 nM
CSc1ccc(Oc2ccc(S(N)(=O)=O)cc2CN(C)C)cc1F CHEMBL491609 IC50 9.0 nM
Clc1ccccc1OC(c1cccnc1)C1CCNCC1 CHEMBL564100 IC50 9.0 nM
O=C(c1ccc2ccccc2c1)N(C1CCC1)[C@@H]1CCNC1 CHEMBL568372 IC50 9.0 nM
CN(CCCc1c[nH]c2ccc(F)cc12)C1COc2ccc3c(c2C1)C(=O)NC3 CHEMBL592028 Ki 9.0 nM
CC(C)C(=O)N(Cc1cccc(Cl)c1Cl)[C@H]1CCNC1 CHEMBL476954 Ki 9.0 nM
COc1cccc(F)c1CC(c1ccccc1)N1CCNCC1 CHEMBL1086274 Ki 9.0 nM
Fc1ccc(C(Cc2ccccc2OC(F)F)N2CCNCC2)cc1 CHEMBL1083425 Ki 9.0 nM
CNC[C@H]1Cc2ccccc2[C@H](c2ccc(Cl)c(Cl)c2)C1 CHEMBL1642906 IC50 9.0 nM
COc1ccccc1-n1c(C)nc(C(=O)NCCCN2CCN(c3cccc(C)c3C)CC2)c1C CHEMBL3216081 IC50 9.0 nM
Fc1ccc(C2(COCc3cc(C(F)(F)F)cc(Cl)n3)CCNCC2)cc1 CHEMBL2333642 IC50 9.0 nM
COc1ccccc1-n1c(C)nc(C(=O)NCCCN2CCN(c3cccc(C)c3C)CC2)c1C CHEMBL1852346 IC50 9.0 nM
CCc1nc(C(=O)NCC(O)CN2CCN(c3cccc(C)c3C)CC2)c(C)n1-c1ccccc1 CHEMBL3681359 IC50 9.0 nM
COCCCC/C(=N\OCCN)c1ccc(Cl)c(Cl)c1 CHEMBL4853402 Ki 9.0 nM
C=Cc1ccc([C@@H]2C[C@H]3CC[C@@H](N3)[C@H]2C(=O)OC)cc1 CHEMBL394157 Ki 9.04 nM
O=C1NCc2cc(F)c(OCCCCN3CCN(c4cccc5cc(F)ccc45)CC3)cc21 CHEMBL1258881 Ki 9.1 nM
Cc1c(Cl)cccc1N1CCN(CC(O)CNC(=O)c2nc(C)n(-c3ccc4c(c3)OCCO4)c2C)CC1 CHEMBL3216957 IC50 9.1 nM
CN1CCC(COCc2cc(C(F)(F)F)cc(C3CC3)n2)(c2cccc(Cl)c2)CC1 CHEMBL2333614 IC50 9.1 nM
CSCC(c1ccc(Cl)c(Cl)c1)C1CCNCC1 CHEMBL2407319 IC50 9.1 nM
Cc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccc2c(c1)OCCO2 CHEMBL3215630 IC50 9.17 nM
Cc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccc2c(c1)OCCO2 CHEMBL1852503 IC50 9.17 nM
CNCc1ccc(Cl)cc1Oc1ccc(Cl)cc1 CHEMBL462387 IC50 9.2 nM
CCSCC(c1ccc(Cl)c(Cl)c1)C1CCNCC1 CHEMBL2407320 IC50 9.2 nM
Clc1ccc(C(Oc2ccccc2)C2CNC2)cc1 CHEMBL2219883 IC50 9.2 nM
O=C1NCc2cc(F)c(OCCCN3CCN(c4cccc5cc(F)ccc45)CC3)cc21 CHEMBL1258763 Ki 9.22 nM
Cc1cc2c(OC[C@@H](O)CN3CC[C@@H](c4cccc5ccsc45)C[C@@H]3C)cccc2[nH]1 CHEMBL2112357 Ki 9.24 nM
CCCc1nc(C(=O)NCC(O)CN2CCN(c3cccc(C)c3C)CC2)c(C)n1-c1ccc2c(c1)OCCO2 CHEMBL3215851 IC50 9.3 nM
CCOC(=O)C(c1ccc(Cl)c(Cl)c1)C1CCNCC1 CHEMBL2407323 IC50 9.3 nM
O=c1[nH]c2ccc(-c3ccc4c(c3)CN3CCC4(c4ccc(Cl)c(Cl)c4)CC3)cc2o1 CHEMBL3673160 IC50 9.3 nM
CNCc1cc(S(=O)(=O)NC)ccc1Oc1ccc(Cl)c(Cl)c1 CHEMBL455424 IC50 9.35 nM
Clc1cccc(CC(c2ccccc2)N2CCNCC2)c1 CHEMBL214240 IC50 9.4 nM
CNCc1cc(F)ccc1Oc1ccc(Cl)cc1 CHEMBL488434 IC50 9.47 nM
Oc1cccc(CC(c2ccccc2)N2CCNCC2)c1 CHEMBL210026 IC50 9.5 nM
Cc1c(Cl)cccc1N1CCN(CCCNC(=O)c2nc(C)n(C3CCCC3)c2C)CC1 CHEMBL3216961 IC50 9.53 nM
CNCC[C@H](Oc1cccc2c(O)cccc12)c1cccs1 CHEMBL324967 Ki 9.6 nM
CC(C)CN(Cc1cc(C(F)(F)F)ccc1Cl)C1CCNCC1 CHEMBL378839 Ki 9.6 nM
CN(C)C1CCC(c2c[nH]c3cc(Br)ccc23)C1 CHEMBL1276249 IC50 9.6 nM
COC(=O)C1C(c2cccc(I)c2)CC2CCC1N2C CHEMBL67387 Ki 9.63 nM
COc1ccccc1S[C@@H](c1ccccc1)[C@@H]1CNCCO1 CHEMBL181188 Ki 9.69 nM
Fc1ccc2[nH]cc(CCCNCCOc3cccc4c3OCC4)c2c1 CHEMBL338982 IC50 9.7 nM
COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CN2 CHEMBL2112983 Ki 9.7 nM
COc1ccc(C2CN(C)Cc3cc(OCCCN(C4CC4)C4CC4)ccc32)cc1 CHEMBL232661 Ki 9.7 nM
CNCc1ccc(Cl)cc1Oc1ccc(F)c(C(F)(F)F)c1 CHEMBL453880 IC50 9.71 nM
CN1C[C@H]2CCCC[C@@]2(c2ccc(Cl)c(Cl)c2)C1 CHEMBL1813314 pIC50 9.772 nM
CCOc1ccccc1C[C@@H](c1ccccc1)N1CCNCC1 CHEMBL540107 IC50 9.8 nM
COc1ccc(-c2ccc3c(c2)CN2CCC3(c3ccc(Cl)c(Cl)c3)CC2)nn1 CHEMBL3673162 IC50 9.8 nM
CNCc1cc(Cl)ccc1Oc1ccc(C)c(C)c1 CHEMBL462225 IC50 9.81 nM
CCc1ccc(CC2CCN(CCc3ccc4c(c3)C(=O)CCO4)CC2)cc1OCCOC CHEMBL4224788 Ki 9.85 nM
CN(C)CC/C=C1\c2ccccc2CSc2ccccc21 CHEMBL1492500 AC50 9.9 nM