Cn1cc(S(=O)(=O)N2CC(CNC(=O)c3ccc(Cl)cc3Cl)(CC3CC3)C2)nn1 CHEMBL485356 IC50 0.1 nM
Cn1cc(S(=O)(=O)N2CC(CNC(=O)c3ccc(Cl)cc3Cl)(c3ncccc3F)C2)nn1 CHEMBL483938 IC50 0.31 nM
CN(CC[C@@H](Oc1ccc(-c2ccccc2)cc1)c1ccc(F)cc1)CC(=O)O CHEMBL180966 IC50 0.39 nM
COc1cc2c(c(Cl)c1Cl)C(=O)C(CCN(C)[C@@H](C)C(=O)O)(c1ccccc1)C2=O CHEMBL379668 IC50 0.47 nM
Cn1cc(S(=O)(=O)N2CCC(CNC(=O)c3ccc(Cl)cc3Cl)(c3ncccc3F)CC2)nn1 CHEMBL521463 IC50 0.65 nM
Cn1cc(S(=O)(=O)N2CCN(C3(CNC(=O)c4ccc(C(F)(F)F)cc4Cl)CCC(F)(F)CC3)CC2)nn1 CHEMBL4593786 IC50 0.671 nM
Cn1cc(S(=O)(=O)N2CCN(C3(CNC(=O)c4c(Cl)cccc4OC(F)(F)F)CCC(F)(F)CC3)CC2)nn1 CHEMBL4526580 IC50 0.726 nM
Cn1cc(S(=O)(=O)N2CCN(C3(CNC(=O)c4ccc(C(F)(F)F)cc4C(F)(F)F)CCC(F)(F)CC3)CC2)nn1 CHEMBL4468117 IC50 0.733 nM
CN(CCC(Oc1ccc(-c2ccccc2)cc1)c1ccc(F)cc1)CC(=O)O CHEMBL26512 Kd 0.8 nM
Cn1cnc(S(=O)(=O)NCCOc2ccc3c(c2)[C@@H](Cc2cccc(C(F)(F)F)c2)[C@@H](N)CC3)c1 CHEMBL4161906 Ki 0.8 nM
Cn1cnc(S(=O)(=O)NCCOc2ccc3c(c2)[C@@H](Cc2ccccc2)[C@@H](N2CCC2)CC3)c1 CHEMBL4169829 Ki 0.8 nM
O=S(=O)(CC1CC1)NC1CN(c2ccc3c(c2)[C@@H](Cc2ccccc2)[C@@H](N2CCC2)CC3)C1 CHEMBL4171521 Ki 0.9 nM
COc1cc2c(c(Cl)c1Cl)C(=O)C(CCN(C)CC(=O)O)(c1ccc(F)cc1)C2=O CHEMBL206851 IC50 0.95 nM
CC(=O)c1ccc(N2CCN(C(=O)c3cc([N+](=O)[O-])ccc3N3CCCCC3)CC2)c(F)c1 CHEMBL496333 EC50 1.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cc(C(F)(F)F)on2)C[C@H]1c1ccc(F)cc1 CHEMBL3913494 IC50 1.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccc(C(F)(F)F)cc2)CC1c1ccccc1 CHEMBL3923537 IC50 1.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2nnc(C(F)(F)F)s2)C[C@H]1c1ccc(Cl)s1 CHEMBL3912223 IC50 1.0 nM
Cn1cnc(S(=O)(=O)N2C[C@H](N[C@@H]3CCc4ccccc43)[C@@H](c3ccc(F)cc3)C2)c1 CHEMBL4165362 Ki 1.0 nM
Cc1cccc(C)c1C(=O)NC(c1ccccc1)C12CCC(CC1)N2C(C)C CHEMBL4228975 IC50 1.0 nM
Cc1cccc(C)c1C(=O)NC(c1ccc(S(=O)(=O)CC2CC2)cc1)C12CCC(CC1)CN2C CHEMBL4225587 IC50 1.0 nM
Cc1cccc(C)c1C(=O)NC(c1ccncc1)C12CCC(CC1)CN2C CHEMBL4224734 IC50 1.0 nM
Cc1ccc(C(NC(=O)c2c(C)cccc2C)C23CCC(CC2)CN3C)o1 CHEMBL4226364 IC50 1.0 nM
Cc1cccc(C)c1C(=O)N[C@H](c1ccccc1)C12CCC(CC1)CN2C CHEMBL4228859 IC50 1.0 nM
CN1CC2CCC1([C@H](NC(=O)c1cccc(Cl)c1Cl)c1ccccc1)CC2 CHEMBL4226039 IC50 1.0 nM
CC(NC(=O)c1ccc(C(F)(F)F)cc1Cl)C1(N2CCN(S(=O)(=O)c3cn(C)nn3)CC2)CCC(F)(F)CC1 CHEMBL4448986 IC50 1.03 nM
Cn1cnc(S(=O)(=O)NCCOc2ccc3c(c2)[C@@H](Cc2ccc(Cl)cc2)[C@@H](N)CC3)c1 CHEMBL4173657 Ki 1.1 nM
Cn1cc(S(=O)(=O)N2CCN(C3(CNC(=O)c4ccc(F)cc4Cl)CCC(F)(F)CC3)CC2)nn1 CHEMBL4456392 IC50 1.14 nM
Cn1cnc(S(=O)(=O)NCCOc2ccc3c(c2)[C@@H](Cc2cc(F)cc(Cl)c2)[C@@H](N)CC3)c1 CHEMBL4166406 Ki 1.2 nM
Cn1cnc(S(=O)(=O)NCCOc2ccc3c(c2)[C@@H](Cc2ccccc2)[C@@H](N2CCCC2)CC3)c1 CHEMBL4165340 Ki 1.2 nM
CN[C@H]1CCc2ccc(OCCNS(=O)(=O)CC3CC3)cc2[C@H]1Cc1ccccc1 CHEMBL4159998 Ki 1.2 nM
Cn1cc(S(=O)(=O)NCCOc2ccc3c(c2)[C@@H](Cc2ccc(Cl)c(Cl)c2)[C@@H](N)CC3)cn1 CHEMBL4161781 Ki 1.2 nM
Cn1cc(S(=O)(=O)N2CCN(C3(CNC(=O)c4ccc(Cl)cc4Cl)CCC(F)(F)CC3)CC2)nn1 CHEMBL4582587 IC50 1.24 nM
Cn1cc(S(=O)(=O)N2CCN(C3(CNC(=O)c4c(Cl)cccc4Cl)CCC(F)(F)CC3)CC2)nn1 CHEMBL4516089 IC50 1.27 nM
Cn1cnc(S(=O)(=O)N2CCN(C3(CNC(=O)c4c(Cl)cccc4OC(F)(F)F)CCC(F)(F)CC3)CC2)c1 CHEMBL4572086 IC50 1.49 nM
Cn1cnc(S(=O)(=O)NCCOc2ccc3c(c2)[C@@H](Cc2cccc(Cl)c2)[C@@H](N)CC3)c1 CHEMBL4163697 Ki 1.5 nM
Cn1cc(S(=O)(=O)N2CCN(C3(CNC(=O)c4ccc(Cl)cc4Cl)CCCCC3)CC2)nn1 CHEMBL4579165 IC50 1.54 nM
Cc1ccc(C(=O)c2ccc(OC(CCN(C)CC(=O)O)c3ccccc3)cc2)cc1 CHEMBL23390 Kd 1.6 nM
Cn1cnc(C(=O)N(Cc2ccc(F)c(C(F)(F)F)c2)[C@H]2C[C@H]3CNC[C@H]3C2)c1 CHEMBL596699 Ki 1.71 nM
Cn1cnc(S(=O)(=O)N2CCC(CNC(=O)c3ccc(Cl)cc3Cl)(c3ncccc3F)CC2)c1 CHEMBL482764 IC50 1.74 nM
Cn1cnc(C(=O)N(Cc2cccc(Cl)c2)[C@H]2CC[C@@H](N)CC2)c1 CHEMBL563761 Ki 1.79 nM
Cn1cnc(C(=O)N(Cc2cccc(Cl)c2)[C@H]2CC[C@@H](N)CC2)c1 CHEMBL3217125 Ki 1.79 nM
Cn1cc(S(=O)(=O)[C@H]2CC[C@@](CNC(=O)c3ccc(Cl)cc3Cl)(CC3CC3)CC2)nn1 CHEMBL482960 IC50 1.89 nM
COc1cc2c(c(Cl)c1Cl)C(=O)C(CCN(C)CC(=O)O)(c1ccccc1)C2=O CHEMBL540967 IC50 1.9 nM
Cn1cnc(C(=O)N(Cc2cccc(OC(F)(F)F)c2)[C@H]2C[C@H]3CNC[C@H]3C2)c1 CHEMBL596700 Ki 1.98 nM
CC(=O)c1ccc(N2CCN(C(=O)c3cc([N+](=O)[O-])ccc3NC(C)C)CC2)c(F)c1 CHEMBL498384 EC50 2.0 nM
CC(=O)c1ccc(N2CCN(C(=O)c3cc([N+](=O)[O-])ccc3NC3CCCCC3)CC2)c(F)c1 CHEMBL497784 EC50 2.0 nM
O=C(NCC1(c2ncccc2F)CCN(S(=O)(=O)CC2CC2)CC1)c1ccc(Cl)cc1Cl CHEMBL484734 IC50 2.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccc(C(F)(F)F)cn2)C[C@H]1c1ccc(F)cc1 CHEMBL3902366 IC50 2.0 nM
Cn1cnc(S(=O)(=O)N2C[C@H](Nc3cccc(OC(F)(F)F)c3)[C@@H](C3OCCCO3)C2)c1 CHEMBL4176089 Ki 2.0 nM
Cn1cnc(S(=O)(=O)N2C[C@H](Nc3cccc(OC(F)(F)F)c3)[C@@H](C3OCCCCO3)C2)c1 CHEMBL4168242 Ki 2.0 nM
Cn1cnc(S(=O)(=O)N2C[C@H](Nc3cccc(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2)c1 CHEMBL4163515 Ki 2.0 nM
Cn1cnc(S(=O)(=O)N2C[C@H](Nc3ccc(F)c(OC(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2)c1 CHEMBL4161627 Ki 2.0 nM
Cc1cccc(C)c1C(=O)NC(c1ccccc1)C12CCC(CC1)N2C1CC1 CHEMBL4225116 IC50 2.0 nM
Cn1cnc(S(=O)(=O)N2CCN(C3(CNC(=O)c4ccc(Cl)cc4Cl)CCCCC3)CC2)c1 CHEMBL4462009 IC50 2.14 nM
CCN1C[C@@H]2[C@H](C1)[C@H]2CN(Cc1cccc(OC(F)(F)F)c1)C(=O)c1cn(C)cn1 CHEMBL564919 Ki 2.24 nM
Cc1ccc(C(=O)c2ccc(O[C@H](CCN(C)CC(=O)O)c3ccccc3)cc2)cc1 CHEMBL551223 Ki 2.32 nM
Cn1cnc(C(=O)N(Cc2cccc(OC(F)(F)F)c2)C[C@H]2[C@@H]3CN(CC4CC4)C[C@@H]32)c1 CHEMBL560750 Ki 2.32 nM
CN1C[C@@H]2[C@H](C1)[C@H]2CN(Cc1cccc(OC(F)(F)F)c1)C(=O)c1cn(C)cn1 CHEMBL556247 Ki 2.32 nM
CN1CCCC[C@H]1[C@@H](NC(=O)c1cccc(C(F)(F)F)c1I)c1ccccc1 CHEMBL1939497 IC50 2.35 nM
Cn1cnc(S(=O)(=O)N2CCN(C3(CNC(=O)c4ccc(C(F)(F)F)cc4Cl)CCC(F)(F)CC3)CC2)c1 CHEMBL4532784 IC50 2.35 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(C(=O)N2CCOCC2)CC1 CHEMBL376472 IC50 2.4 nM
CCCS(=O)(=O)N1CCC(c2ccccc2)([C@H](C)NC(=O)c2ccc(Cl)cc2Cl)CC1 CHEMBL3114792 IC50 2.4 nM
Cn1cnc(C(=O)N(Cc2ccc(F)c(OC3CCCC3)c2)[C@H]2C[C@H]3CNC[C@H]3C2)c1 CHEMBL599060 Ki 2.44 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(c2cccc(C)n2)CC1 CHEMBL464508 IC50 2.5 nM
CN1C[C@H]2C[C@@H](N(Cc3cccc(OC(F)(F)F)c3)C(=O)c3cn(C)cn3)C[C@H]2C1 CHEMBL598659 Ki 2.5 nM
CN1CCCC[C@H]1[C@@H](NC(=O)c1cccc(C(F)(F)F)c1Cl)c1ccccc1 CHEMBL1939495 IC50 2.5 nM
CCn1cc(S(=O)(=O)N2CC(CNC(=O)c3ccc(Cl)cc3Cl)(CC3CC3)C2)nn1 CHEMBL483344 IC50 2.58 nM
CCCS(=O)(=O)N1CCC(c2ccccc2)([C@H](C)NC(=O)c2c(N)cccc2Cl)CC1 CHEMBL463477 IC50 2.6 nM
O=S(=O)(CC1CC1)NCCOc1ccc2c(c1)[C@@H](Cc1ccccc1)[C@@H](N1CCC1)CC2 CHEMBL4173253 Ki 2.6 nM
CCCS(=O)(=O)NC1CN(c2ccc3c(c2)[C@@H](Cc2ccccc2)[C@@H](N2CCC2)CC3)C1 CHEMBL4174959 Ki 2.6 nM
Cn1cnc(S(=O)(=O)NCCOc2ccc3c(c2)[C@@H](Cc2ccc(Cl)c(Cl)c2)[C@@H](N)CC3)c1 CHEMBL4166296 Ki 2.6 nM
CCN1C[C@H]2C[C@@H](N(Cc3ccc(F)c(C(F)(F)F)c3)C(=O)c3cn(C)cn3)C[C@H]2C1 CHEMBL599480 Ki 2.64 nM
Cn1cnc(C(=O)N(Cc2cccc(OC(F)(F)F)c2)[C@@H]2C[C@@H]3CN(CC(O)c4ccccc4)C[C@@H]3C2)c1 CHEMBL597033 Ki 2.79 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(C2CCCCC2O)CC1 CHEMBL464417 IC50 2.8 nM
COc1cc2c(c(Cl)c1Cl)C(=O)C(CCN(C)[C@@H](CO)C(=O)O)(c1ccccc1)C2=O CHEMBL204397 IC50 2.9 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC2CCCCO2)CC1 CHEMBL518238 IC50 2.9 nM
CN1C[C@H]2C[C@@H](N(Cc3ccc(F)c(C(F)(F)F)c3)C(=O)c3cn(C)cn3)C[C@H]2C1 CHEMBL603695 Ki 2.9 nM
Cn1cc(S(=O)(=O)N2CC(CNC(=O)c3ccc(Cl)cc3Cl)(c3ncccc3F)C2)cn1 CHEMBL521182 IC50 2.95 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2Cl)(c2cccc(C)n2)CC1 CHEMBL518070 IC50 3.0 nM
CCCS(=O)(=O)N1CCC(c2ccccn2)([C@H](C)NC(=O)c2ccc(Cl)cc2Cl)CC1 CHEMBL460537 IC50 3.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cc(C(F)(F)F)on2)CC1c1ccccc1F CHEMBL3967342 IC50 3.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cnc(C(F)(F)F)cn2)CC1c1ccc(F)s1 CHEMBL3944165 IC50 3.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1c1ccc(F)s1 CHEMBL3890483 IC50 3.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C(F)(F)F)cn2)C[C@H]1c1ccc(Cl)s1 CHEMBL3905796 IC50 3.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccc(Cl)cc2)CC1c1ccccc1 CHEMBL3891053 IC50 3.0 nM
Cn1cc(S(=O)(=O)N2C[C@H](Nc3ccc(F)c(C(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2)nn1 CHEMBL4175977 Ki 3.0 nM
Cn1cnc(S(=O)(=O)N2C[C@H]([C@H]3CCCCO3)[C@@H](Nc3cccc(OC(F)(F)F)c3)C2)c1 CHEMBL4160468 Ki 3.0 nM
Cn1cnc(S(=O)(=O)N2CC(Nc3cccc(C(F)(F)F)c3)C(c3ccc(F)cc3)C2)c1 CHEMBL4176431 Ki 3.0 nM
Cn1cnc(S(=O)(=O)N2CC(Nc3cccc(Cl)c3)C(c3ccc(F)cc3)C2)c1 CHEMBL4174148 Ki 3.0 nM
Cn1cnc(S(=O)(=O)NCc2ccc3c(c2)[C@@H](Cc2ccccc2)[C@@H](N2CCC2)CC3)c1 CHEMBL4167917 Ki 3.0 nM
CCCS(=O)(=O)NCCOc1ccc2c(c1)C(C1(c3ccc(Cl)cc3)CCC1)NCC2 CHEMBL3643445 Ki 3.0 nM
CCN1CC2CC1(C(NC(=O)c1c(C)cccc1C)c1ccccc1)C2 CHEMBL4225641 IC50 3.0 nM
Cc1cccc(C)c1C(=O)NC(c1ccccc1)C12CCC(CC1)N2C CHEMBL4228817 IC50 3.0 nM
Cc1cccc(C)c1C(=O)NC(c1ccccc1)C12CCC(CC1)CN2 CHEMBL4225853 IC50 3.0 nM
CSc1ncccc1C(=O)N[C@H](c1ccccc1)C12CCC(CC1)CN2C CHEMBL4224768 IC50 3.0 nM
Cn1cnc(S(=O)(=O)NCCOc2ccc3c(c2)[C@@H](Cc2ccccc2)[C@@H](N2CCC2)CO3)c1 CHEMBL4164744 Ki 3.3 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(c2cc(C)ccn2)CC1 CHEMBL465428 IC50 3.5 nM
Cn1cnc(S(=O)(=O)NCCOc2ccc3c(c2)[C@@H](Cc2ccccc2)[C@@H](N)CC3)c1 CHEMBL4162953 Ki 3.6 nM
Cn1cc(S(=O)(=O)N2CC(CNC(=O)c3ccc(Cl)cc3Cl)(CC3CC3)C2)cn1 CHEMBL485355 IC50 3.62 nM
CN1C[C@H]2C[C@@H](N(Cc3ccc(F)c(OC4CCCC4)c3)C(=O)c3cn(C)cn3)C[C@H]2C1 CHEMBL599482 Ki 3.76 nM
Cn1cnc(C(=O)N(Cc2cccc(OC(F)(F)F)c2)C[C@H]2[C@@H]3CN(CC4CCCC4)C[C@@H]32)c1 CHEMBL563220 Ki 3.82 nM
CCN1C[C@H]2C[C@@H](N(Cc3cccc(OC(F)(F)F)c3)C(=O)c3cn(C)cn3)C[C@H]2C1 CHEMBL604805 Ki 3.82 nM
CC(C)Oc1cccc(CN(C(=O)c2cn(C)cn2)[C@H]2C[C@H]3CNC[C@H]3C2)c1 CHEMBL599264 Ki 3.96 nM
O=C1NCN(c2ccccc2)C12CCN([C@@H]1CCCC[C@@H]1c1ccccc1)CC2 CHEMBL383539 EC50 4.0 nM
CCCS(=O)(=O)N1CCC(c2ccccn2)([C@H](C)NC(=O)c2cc(F)cc(F)c2Cl)CC1 CHEMBL517410 IC50 4.0 nM
Cn1cnc(S(=O)(=O)N2C[C@@H]3[C@H](C2)[C@@]3(CNC(=O)c2ccc(Cl)cc2Cl)CC2CC2)c1 CHEMBL3114969 IC50 4.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1c1cccc(F)c1F CHEMBL3954728 IC50 4.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C(F)(F)F)cn2)C[C@H]1c1ccccc1F CHEMBL3893445 IC50 4.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cc(C(F)(F)F)on2)CC1c1cccc(F)c1F CHEMBL3931741 IC50 4.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cc(C(F)(F)F)on2)CC1c1ccc(F)cc1F CHEMBL3977960 IC50 4.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cc(C(F)(F)F)on2)CC1c1ccc(F)c(F)c1 CHEMBL3952183 IC50 4.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2noc(C(F)F)n2)CC1c1ccc(Cl)s1 CHEMBL3923971 IC50 4.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C(F)(F)F)cn2)C[C@H]1c1ccc(F)cc1 CHEMBL3937690 IC50 4.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C3CC3)cn2)CC1c1ccc(F)s1 CHEMBL3907259 IC50 4.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cc(C(F)(F)F)on2)CC1c1ccccc1 CHEMBL3899547 IC50 4.0 nM
Cn1cnc(S(=O)(=O)N2C[C@H](Nc3cccc(OC(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2)c1 CHEMBL4159064 Ki 4.0 nM
Cc1cc(-n2cc3c(n2)CN(C(=O)c2cc(S(C)(=O)=O)ccc2-c2cccc(F)c2)C3)ccn1 CHEMBL4202565 IC50 4.0 nM
CCN1C2CCC1(C(NC(=O)c1c(C)cccc1C)c1ccccc1)CC2 CHEMBL4225056 IC50 4.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(c2ncccc2F)CC1 CHEMBL484733 IC50 4.33 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(c2ccccn2)CC1 CHEMBL518340 IC50 4.4 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3c(OC)cc(C(F)(F)F)cc3C(F)(F)F)CCCCC2)CC1 CHEMBL2324479 IC50 4.4 nM
CC(F)CN1C[C@H]2C[C@@H](N(Cc3cccc(OC(F)(F)F)c3)C(=O)c3cn(C)cn3)C[C@H]2C1 CHEMBL605540 Ki 4.44 nM
CCN1C[C@@H]2[C@H](C1)[C@H]2CN(Cc1cccc(Cl)c1)C(=O)c1cn(C)cn1 CHEMBL551424 Ki 4.58 nM
Cn1cnc(S(=O)(=O)N2C[C@@H]3[C@H](C2)[C@@]3(CNC(=O)c2ccccc2C(F)(F)F)CC2CC2)c1 CHEMBL3114971 IC50 5.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C(F)(F)F)cn2)C[C@H]1c1cccc(F)c1F CHEMBL3914436 IC50 5.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C(F)(F)F)cn2)C[C@H]1c1cccc(F)c1 CHEMBL3905461 IC50 5.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1c1ccc(F)cc1F CHEMBL3987035 IC50 5.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C(F)(F)F)cn2)C[C@H]1c1ccc(F)cc1F CHEMBL3935263 IC50 5.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccc(C(F)(F)F)cn2)CC1c1cccc(F)c1F CHEMBL3981293 IC50 5.0 nM
Cn1cnc(S(=O)(=O)N2CC(Nc3ccc(F)c(C(F)(F)F)c3)C(c3ccc(F)cc3)C2)c1 CHEMBL4166232 Ki 5.0 nM
Cn1cnc(S(=O)(=O)N2C[C@H](Nc3cc(C(F)(F)F)ncn3)[C@@H](c3ccc(F)cc3)C2)c1 CHEMBL4172249 Ki 5.0 nM
Cn1cnc(S(=O)(=O)N2CCN(C3(CNC(=O)c4ccc(F)cc4Cl)CCC(F)(F)CC3)CC2)c1 CHEMBL4573115 IC50 5.09 nM
Cn1cc(S(=O)(=O)N2CCN(C3(CNC(=O)c4c(F)cccc4F)CCC(F)(F)CC3)CC2)nn1 CHEMBL4555741 IC50 5.1 nM
Cn1cnc(S(=O)(=O)N2CCN(C3(CNC(=O)c4ccc(Cl)cc4Cl)CCC(F)(F)CC3)CC2)c1 CHEMBL4439865 IC50 5.29 nM
Cn1cnc(C(=O)N(Cc2cccc(OC3CCCC3)c2)[C@H]2C[C@H]3CNC[C@H]3C2)c1 CHEMBL603691 Ki 5.3 nM
Cn1cc(S(=O)(=O)[C@H]2CC[C@](CNC(=O)c3ccc(Cl)cc3Cl)(CC3CC3)CC2)nn1 CHEMBL520648 IC50 5.4 nM
Cn1cc(S(=O)(=O)N2CCC(CNC(=O)c3ccc(Cl)cc3Cl)(c3ncccc3F)CC2)cn1 CHEMBL483157 IC50 5.43 nM
Cn1cnc(S(=O)(=O)N2CCN(C3(CNC(=O)c4c(Cl)cccc4Cl)CCC(F)(F)CC3)CC2)c1 CHEMBL4475426 IC50 5.56 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2c(F)ccc(F)c2Cl)(c2ccccn2)CC1 CHEMBL464506 IC50 5.7 nM
N[C@H]1CCc2ccc(OCCNS(=O)(=O)CC3CC3)cc2[C@H]1Cc1ccc(Cl)c(Cl)c1 CHEMBL4165214 Ki 5.7 nM
Cn1cnc(C(=O)N(Cc2cccc(OC(F)(F)F)c2)[C@@H]2C[C@@H]3CN(CC(C)(C)O)C[C@@H]3C2)c1 CHEMBL605744 Ki 5.74 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C(F)(F)F)cn2)C[C@H]1c1ccc(F)c(F)c1 CHEMBL3949559 IC50 6.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cnc(C(F)(F)F)cn2)C[C@H]1c1ccc(F)cc1 CHEMBL3893261 IC50 6.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cc(C(F)(F)F)on2)CC1c1ccc(F)s1 CHEMBL3943064 IC50 6.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cc(C(F)(F)F)on2)CC1c1ccc(Cl)s1 CHEMBL3916214 IC50 6.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C3CC3)cn2)CC1c1ccccc1F CHEMBL3948776 IC50 6.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C3CC3)cn2)CC1c1ccc(F)cc1 CHEMBL3930351 IC50 6.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccc(Cl)cc2)CC1c1cccs1 CHEMBL3965980 IC50 6.0 nM
Cc1ccc(C2CN(c3ccc(C(F)(F)F)cn3)CCN2C(=O)C2CCS(=O)(=O)CC2)s1 CHEMBL3960777 IC50 6.0 nM
CS(=O)(=O)c1ccc(-c2cccc(F)c2)c(C(=O)N2Cc3cn(-c4cncc(F)c4)nc3C2)c1 CHEMBL4214250 IC50 6.0 nM
COc1cccc(OC)c1C(=O)N[C@H](c1ccccc1)C12CCC(CC1)CN2C CHEMBL4227823 IC50 6.0 nM
CN1CC2CCC1([C@H](NC(=O)c1ccnc(Cl)c1Cl)c1ccccc1)CC2 CHEMBL4225613 IC50 6.0 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3c(OC)cc(F)cc3SC)CCCCC2)CC1 CHEMBL2324480 IC50 6.1 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2cc(F)c(Cl)cc2Cl)(C(=O)N2CCOCC2)CC1 CHEMBL223199 IC50 6.3 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3c(N)cccc3Cl)CCCCCC2)CC1 CHEMBL2324483 IC50 6.3 nM
CC[C@@H](C)N(C)CCC1(c2ccc(F)cc2)C(=O)c2cc(OC)c(Cl)c(Cl)c2C1=O CHEMBL382336 IC50 6.4 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2c(Cl)cccc2Cl)(c2ccccn2)CC1 CHEMBL464087 IC50 6.6 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2c(N)cccc2Cl)(c2ccccn2)CC1 CHEMBL464088 IC50 6.9 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2Cl)(c2cccc(OC)n2)CC1 CHEMBL465333 IC50 6.9 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2nnc(C(F)(F)F)s2)CC1c1ccc(F)s1 CHEMBL3935194 IC50 7.0 nM
Cc1cnc(N2CCN(C(=O)C3CCS(=O)(=O)CC3)C(c3ccc(F)s3)C2)nc1 CHEMBL3922062 IC50 7.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cnc(C(F)(F)F)cn2)CC1c1ccc(Cl)s1 CHEMBL3980935 IC50 7.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cc(C(F)(F)F)on2)CC1c1cccc(F)c1 CHEMBL3909824 IC50 7.0 nM
Cn1cnc(S(=O)(=O)N2C[C@H](COc3cccc(OC(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2)c1 CHEMBL4161927 Ki 7.0 nM
Cc1cc(-n2cc3c(n2)CN(C(=O)c2cc(S(C)(=O)=O)ccc2N2CCC(F)(F)CC2)C3)ccn1 CHEMBL4217712 IC50 7.0 nM
Cc1cccc(C)c1C(=O)NC(c1ccccc1)C12CC(CN1C)C2 CHEMBL4225053 IC50 7.0 nM
Cc1cc(S(=O)(=O)[C@H]2CC[C@](CNC(=O)c3ccc(Cl)cc3Cl)(CC3CC3)CC2)no1 CHEMBL2146711 IC50 7.3 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(c2cccc(OC)n2)CC1 CHEMBL463432 IC50 7.4 nM
CS(=O)(=O)c1ccc(OC2CCCCC2)c(C(=O)N2CCN(c3ccc(C#N)cc3F)CC2)c1 CHEMBL1173764 EC50 8.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cc(C(F)(F)F)on2)CC1c1ccc(F)cc1 CHEMBL3910193 IC50 8.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cnc(C3CC3)cn2)CC1c1ccccc1F CHEMBL3957904 IC50 8.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C3CC3)cn2)CC1c1ccc(Cl)s1 CHEMBL3920972 IC50 8.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2noc(C(F)(F)F)n2)CC1c1ccccc1F CHEMBL3982362 IC50 8.0 nM
Cc1ccc(C2CN(c3ncc(C(F)(F)F)cn3)CCN2C(=O)C2CCS(=O)(=O)CC2)s1 CHEMBL3924511 IC50 8.0 nM
Cn1cnc(S(=O)(=O)N2CC(Nc3cccc(C(F)(F)F)c3)C(c3ccccc3)C2)c1 CHEMBL4162798 Ki 8.0 nM
Cn1cnc(S(=O)(=O)N2C[C@H](Nc3cc(C(F)(F)F)ccn3)[C@@H](c3ccc(F)cc3)C2)c1 CHEMBL4166963 Ki 8.0 nM
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1Cc2cn(-c3ccccc3F)nc2C1)C(F)(F)F CHEMBL4211012 IC50 8.0 nM
CN1CC2CCC1([C@H](NC(=O)c1c(N)cccc1Cl)c1ccccc1)CC2 CHEMBL4224738 IC50 8.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2c(F)ccc(Cl)c2F)(C(=O)N2CCOCC2)CC1 CHEMBL222720 IC50 8.4 nM
CCS(=O)(=O)N1CCN(C2(CNC(=O)c3ccc(C(F)(F)F)cc3C(F)(F)F)CCC(F)(F)CC2)CC1 CHEMBL4447922 IC50 8.4 nM
Cc1cc(S(=O)(=O)[C@H]2CC[C@@](CNC(=O)c3ccc(Cl)cc3Cl)(CC3CC3)CC2)no1 CHEMBL2146712 IC50 8.6 nM
CCC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc(C(C)=O)cc2F)CC1 CHEMBL498601 EC50 9.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1c1cccc(F)c1 CHEMBL3914818 IC50 9.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1c1ccccc1F CHEMBL3900034 IC50 9.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccc(C(F)(F)F)cn2)CC1c1ccc(F)cc1F CHEMBL3961983 IC50 9.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C3CC3)cn2)CC1c1cccc(F)c1 CHEMBL3941912 IC50 9.0 nM
Cc1cnc(N2CCN(C(=O)C3CCS(=O)(=O)CC3)C(c3ccc(Cl)s3)C2)nc1 CHEMBL3959524 IC50 9.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2noc(C(F)(F)F)n2)CC1c1ccc(F)cc1 CHEMBL3986062 IC50 9.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccc(C(F)(F)F)cn2)CC1c1cccc(F)c1 CHEMBL3984112 IC50 9.0 nM
CN1CC2CCC1(C(NC(=O)c1cccc(C(F)(F)F)c1Cl)c1cccc(Br)c1)CC2 CHEMBL4226374 IC50 9.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(C2CCCCN2C)CC1 CHEMBL464617 IC50 9.5 nM
CCCS(=O)(=O)NCc1ccc2c(c1)[C@@H](Cc1ccccc1)[C@@H](NC)CC2 CHEMBL4172640 Ki 9.5 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2Cl)(C(=O)N2CCOCC2)CC1 CHEMBL219714 IC50 9.7 nM
CC(F)CS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(c2ccccn2)CC1 CHEMBL461986 IC50 9.7 nM
CC(C)COc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc(C#N)cc2F)CC1 CHEMBL1173634 EC50 10.0 nM
COc1cc(C(F)(F)F)cc(SC)c1C(=O)N[C@@]1(c2ccccc2)CCCN(C)C1 CHEMBL3259928 EC50 10.0 nM
Cc1cnc(N2CCN(C(=O)C3CCS(=O)(=O)CC3)C(c3ccc(F)s3)C2)cn1 CHEMBL3953355 IC50 10.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2noc(C(F)F)n2)CC1c1ccc(F)cc1 CHEMBL3919833 IC50 10.0 nM
COc1ccc(N2CCN(C(=O)C3CCS(=O)(=O)CC3)C(c3ccccc3)C2)cc1C(F)(F)F CHEMBL3986089 IC50 10.0 nM
CS(=O)(=O)c1ccc(-c2cccc(F)c2)c(C(=O)N2Cc3cn(-c4ccccc4F)nc3C2)c1 CHEMBL4205995 IC50 10.0 nM
CS(=O)(=O)c1ccc(N2CCC(F)(F)CC2)c(C(=O)N2Cc3cn(-c4cncc(F)c4)nc3C2)c1 CHEMBL4210353 IC50 10.0 nM
CC(C)(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1Cc2cn(-c3ccccc3F)nc2C1 CHEMBL4216391 IC50 10.0 nM
Cc1cccc(C)c1C(=O)NC(c1ccncc1)C12CCC(CC1)N2C(C)C CHEMBL4229134 IC50 10.0 nM
OCC1CCCN(CCCC2CCCc3ccc(OCc4noc(-c5ccccc5F)n4)cc32)C1 CHEMBL394236 Ki 10.2 nM
Cn1cc(S(=O)(=O)N2CCC(CNC(=O)c3ccc(Cl)cc3Cl)(CC3CC3)CC2)cn1 CHEMBL482974 IC50 10.35 nM
Cn1cnc(C(=O)N(Cc2cccc(OC(F)(F)F)c2)[C@@H]2C[C@@H]3CN(CCC(F)(F)F)C[C@@H]3C2)c1 CHEMBL597032 Ki 10.5 nM
OCC1CCCN(CCCC2CCCc3ccc(OCc4ccc(-c5ccccc5F)cn4)cc32)C1 CHEMBL239605 Ki 11.0 nM
CCS(=O)(=O)N1CCC(c2ccccn2)([C@H](C)NC(=O)c2ccc(Cl)cc2Cl)CC1 CHEMBL516342 Activity 11.0 nM
CN1C[C@@H]2[C@H](C1)[C@H]2CN(Cc1cccc(Cl)c1)C(=O)c1cn(C)cn1 CHEMBL537965 Ki 11.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1c1ccc(F)c(F)c1 CHEMBL3962045 IC50 11.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cnc(C(F)(F)F)cn2)CC1c1cccc(F)c1F CHEMBL3925723 IC50 11.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccc(C(F)(F)F)cn2)CC1c1ccc(F)c(F)c1 CHEMBL3941078 IC50 11.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccc(F)cn2)CC1c1ccc(F)cc1 CHEMBL3961146 IC50 11.0 nM
O=C(NCC1(c2ncccc2F)CCN(S(=O)(=O)c2cccnc2)CC1)c1ccc(Cl)cc1Cl CHEMBL485139 IC50 11.55 nM
CN1C[C@@H]2[C@H](C1)[C@H]2CN(Cc1ccc(F)c(Cl)c1)C(=O)c1cn(C)cn1 CHEMBL563251 Ki 11.6 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2Cl)(c2ccccn2)CC1 CHEMBL464420 IC50 11.9 nM
CN(CCOc1ccc(-c2ccc3c(c2)OCO3)cc1-c1ccccc1Cl)CC(=O)O CHEMBL248734 IC50 12.0 nM
CS(=O)(=O)c1ccc(N2CCCCC2)c(C(=O)N2CCN(c3ccc(C#N)cc3F)CC2)c1 CHEMBL497998 EC50 12.0 nM
CS(=O)(=O)c1ccc(OC2CCCC2)c(C(=O)N2CCN(c3ccc(C#N)cc3F)CC2)c1 CHEMBL1173698 EC50 12.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2noc(C(F)F)n2)CC1c1ccccc1F CHEMBL3906948 IC50 12.0 nM
CCS(=O)(=O)c1ccc(O[C@@H](C)C(F)(F)F)c(C(=O)N2Cc3cn(-c4ccnc(C)c4)nc3C2)c1 CHEMBL4206403 IC50 12.0 nM
Cc1cc(-n2cc3c(n2)CN(C(=O)c2cc(S(C)(=O)=O)ccc2O[C@@H](C)C(F)(F)F)C3)ccn1 CHEMBL4218366 IC50 12.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2c(F)cccc2Cl)(C(=O)N2CCOCC2)CC1 CHEMBL223743 IC50 12.5 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(F)cc2Cl)(C(=O)N2CCOCC2)CC1 CHEMBL222899 IC50 12.6 nM
CCS(=O)(=O)N1CCN(C2(CNC(=O)c3ccc(C(F)(F)F)cc3Cl)CCC(F)(F)CC2)CC1 CHEMBL4458568 IC50 12.6 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3c(Cl)cccc3Cl)CCCCC2)CC1 CHEMBL2324478 IC50 12.8 nM
CN(CCOc1ccc(-c2ccc3c(c2)CCO3)cc1-c1ccccc1Cl)CC(=O)O CHEMBL399784 IC50 13.0 nM
CC(Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc(C(F)(F)F)cc2F)CC1)C(F)(F)F CHEMBL1172199 EC50 13.0 nM
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1Cc2ccc(-c3ccccc3)cc2C1)C(F)(F)F CHEMBL1631010 EC50 13.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1c1ccc(F)cc1 CHEMBL3936442 IC50 13.0 nM
CN(CCOc1ccc(-c2ccc3c(c2)OCCO3)cc1-c1ccccc1Cl)CC(=O)O CHEMBL399033 IC50 14.0 nM
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1Cc2ccc(C3CCOCC3)cc2C1)C(F)(F)F CHEMBL1631023 EC50 14.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccc(F)cn2)CC1c1ccc(F)cc1F CHEMBL3910254 IC50 14.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccc(C3CC3)nc2)CC1c1cccc(F)c1 CHEMBL3955475 IC50 14.0 nM
Cc1cnc(N2CCN(C(=O)C3CCS(=O)(=O)CC3)C(c3ccc(Cl)s3)C2)cn1 CHEMBL3922537 IC50 14.0 nM
O=C1NCN(c2ccc(Cl)cc2)C12CCN([C@@H]1CCCC[C@@]1(O)c1ccc(F)cc1)CC2 CHEMBL200883 EC50 15.0 nM
CC(=O)c1ccc(N2CCN(C(=O)c3cc([N+](=O)[O-])ccc3N3CCOCC3)CC2)c(F)c1 CHEMBL526280 EC50 15.0 nM
CC(=O)c1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3OCC3CC3)CC2)c(F)c1 CHEMBL495510 EC50 15.0 nM
CC(=O)c1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3SC(C)C)CC2)c(F)c1 CHEMBL523397 EC50 15.0 nM
N#Cc1cc(C(F)(F)F)ccc1N1CCN(C(=O)c2cc([N+](=O)[O-])ccc2N2CCOCC2)CC1 CHEMBL495915 EC50 15.0 nM
Cn1cc(S(=O)(=O)N2CC3CCC(NC(=O)c4ccc(Cl)cc4Cl)C3C2)nn1 CHEMBL3115220 IC50 15.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccc3ccccc3c2)CC1c1ccccc1 CHEMBL3951251 IC50 15.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccc(C(F)(F)F)cc2)CC1c1cccs1 CHEMBL3909164 IC50 15.0 nM
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1Cc2cn(-c3ccccc3)nc2C1)C(F)(F)F CHEMBL4210484 IC50 15.0 nM
COc1c(S(C)(=O)=O)ccc(O[C@@H](C)C(F)(F)F)c1C(=O)N1CC(c2ncc(C(F)(F)F)cc2Cl)C1 CHEMBL4640428 IC50 15.0 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3c(N)cccc3Cl)CCCCC2)CC1 CHEMBL2324158 IC50 15.1 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3c(N)cccc3Cl)CCCCC2)CC1 CHEMBL4579970 IC50 15.1 nM
Cn1cnc(C(=O)N(Cc2cccc(OC(F)(F)F)c2)C[C@H]2[C@@H]3CNC[C@@H]32)c1 CHEMBL564650 Ki 15.2 nM
OCC1CCCN(CCCC2CCCc3ccc(OCc4noc(-c5ccc(Cl)cc5)n4)cc32)C1 CHEMBL239603 Ki 15.9 nM
CC(=O)c1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3-c3cccc(F)c3)CC2)c(F)c1 CHEMBL492045 EC50 16.0 nM
CS(=O)(=O)c1ccc(OCC2CC2)c(C(=O)N2CCN(c3ccc(C#N)cc3F)CC2)c1 CHEMBL497999 EC50 16.0 nM
O=C(CNC(=O)c1ccc(F)cc1)NC(c1cccc(F)c1)c1cccc(F)c1 CHEMBL476557 EC50 16.0 nM
CS(=O)(=O)c1ccc(-c2ccc(F)cc2)c(C(=O)N2Cc3ccc(C4CCOCC4)cc3C2)c1 CHEMBL1631198 EC50 16.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cnc(C(F)(F)F)cn2)CC1c1ccc(F)c(F)c1 CHEMBL3925609 IC50 16.0 nM
CS(=O)(=O)c1ccc(N2CCC(F)(F)CC2)c(C(=O)N2Cc3cn(-c4ccccc4F)nc3C2)c1 CHEMBL4205471 IC50 16.0 nM
CN1CC2CCC1([C@H](NC(=O)c1cccc(C(F)(F)F)c1Cl)c1ccccc1)CC2 CHEMBL4229192 IC50 16.0 nM
CN(CCOc1ccc(-c2ccc3c(c2)CCO3)cc1-c1cccs1)CC(=O)O CHEMBL399034 IC50 17.0 nM
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1Cc2ccc(-c3ccncc3)cc2C1)C(F)(F)F CHEMBL1631021 EC50 17.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cnc(C(F)(F)F)cn2)CC1c1ccc(F)cc1 CHEMBL3921257 IC50 17.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2nc3ccccc3s2)CC1c1ccccc1 CHEMBL3917531 IC50 17.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cccc(Cl)c2)CC1c1cccs1 CHEMBL3945986 IC50 17.0 nM
Cc1cccc(NC2CN(S(=O)(=O)c3cn(C)cn3)CC2c2ccccc2)c1 CHEMBL4172970 Ki 17.0 nM
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1Cc2cn(C3CCCC3)nc2C1)C(F)(F)F CHEMBL4218894 IC50 17.0 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3ccc(OC)cc3F)CCCCC2)CC1 CHEMBL2324166 IC50 17.1 nM
CCCS(=O)(=O)N1CCC(c2ccccn2)([C@H](C)NC(=O)c2ccccc2OC(F)(F)F)CC1 CHEMBL454412 IC50 17.7 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(C2CCCCC2OC(C)=O)CC1 CHEMBL462147 IC50 17.7 nM
COc1ccc(-c2ccc(OCCN(C)CC(=O)O)c(C(=O)c3cccs3)c2)cc1C CHEMBL399961 IC50 18.0 nM
CS(=O)(=O)c1ccc(OC2CCC2)c(C(=O)N2CCN(c3ccc(C#N)cc3F)CC2)c1 CHEMBL1173695 EC50 18.0 nM
Cc1cnc(N2CCN(C(=O)C3CCS(=O)(=O)CC3)C(c3cccc(F)c3)C2)nc1 CHEMBL3893389 IC50 18.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cnc(C(F)(F)F)cn2)CC1c1ccccc1F CHEMBL3894470 IC50 18.0 nM
O=S(=O)(CC1CC1)NC1CN(c2ccc3c(c2)[C@@H](Cc2ccccc2)[C@@H](N2CCC2)CO3)C1 CHEMBL4164312 Ki 18.0 nM
Cc1cc(-n2cc3c(n2)CN(C(=O)c2cc(C#N)ccc2O[C@@H](C)C(F)(F)F)C3)ccn1 CHEMBL4215015 IC50 18.0 nM
CN1CC2CCC1(C(NC(=O)c1cccc(C(F)(F)F)c1Cl)c1ccncc1)CC2 CHEMBL4225262 IC50 18.0 nM
Cn1cnc(S(=O)(=O)N2CCN(C3(CNC(=O)c4c(F)cccc4F)CCC(F)(F)CC3)CC2)c1 CHEMBL4450109 IC50 18.3 nM
COc1cc2c(c(Cl)c1Cl)C(=O)C(CCN(C)[C@H](C)C(=O)O)(c1ccccc1)C2=O CHEMBL426315 IC50 19.0 nM
CN(CCC1(c2ccccc2)C(=O)c2cc(Cl)c(Cl)cc2C1=O)CC(=O)O CHEMBL382006 IC50 19.0 nM
CN(CCOc1ccc(-c2ccc3c(c2)OCO3)cc1C(=O)c1cccs1)CC(=O)O CHEMBL250171 IC50 19.0 nM
Cn1cnc(S(=O)(=O)N2C[C@@H]3[C@H](C2)[C@@]3(CNC(=O)c2ccccc2Cl)CC2CC2)c1 CHEMBL3114788 IC50 19.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cnc(C3CC3)nc2)CC1c1ccc(F)cc1 CHEMBL3936856 IC50 19.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cnc(C(F)(F)F)nc2)CC1c1ccc(F)s1 CHEMBL3935823 IC50 19.0 nM
COc1c(S(C)(=O)=O)ccc(O[C@@H](C)C(F)(F)F)c1C(=O)N1Cc2cn(-c3ccc(F)cn3)nc2C1 CHEMBL4638182 IC50 19.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2OC(F)(F)F)(c2ccccn2)CC1 CHEMBL517034 IC50 19.4 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2C)(c2ccccn2)CC1 CHEMBL518692 IC50 19.5 nM
CS(=O)(=O)c1ccc(-c2ccccc2)c(C(=O)N2CCN(c3ccc(C#N)cc3F)CC2)c1 CHEMBL496966 EC50 20.0 nM
COC(C)c1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3-c3ccc(F)cc3)CC2)c(F)c1 CHEMBL3746420 IC50 20.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccc(F)cn2)CC1c1ccc(F)c(F)c1 CHEMBL3916802 IC50 20.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccccc2)CC1c1cccs1 CHEMBL3927636 IC50 20.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccc(Cl)c(C(F)(F)F)c2)CC1c1ccccc1 CHEMBL3914516 IC50 20.0 nM
Cc1cc(-n2cc3c(n2)CN(C(=O)c2cc(C#N)ccc2N2CCC(F)(F)CC2)C3)ccn1 CHEMBL4211535 IC50 20.0 nM
CC(Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc(C#N)cc2)CC1)C(F)(F)F CHEMBL1171498 EC50 21.0 nM
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1Cc2ccc(C(F)(F)F)cc2C1)C(F)(F)F CHEMBL1631009 EC50 21.0 nM
Cc1ccc(N2CCN(C(=O)C3CCS(=O)(=O)CC3)C(c3ccccc3F)C2)nc1 CHEMBL3912405 IC50 21.0 nM
COc1ccc(N2CCN(C(=O)C3CCS(=O)(=O)CC3)C(c3cccs3)C2)cc1C(F)(F)F CHEMBL3918015 IC50 21.0 nM
Cc1ccc(C2CN(c3nnc(C(F)(F)F)s3)CCN2C(=O)C2CCS(=O)(=O)CC2)s1 CHEMBL3934987 IC50 21.0 nM
Cn1cnc(S(=O)(=O)N2CC(Nc3cccc(Cl)c3)C(c3ccccc3F)C2)c1 CHEMBL4170790 Ki 21.0 nM
Cc1cc(-n2cc3c(n2)CN(C(=O)c2cc(C#N)ccc2OC(C)C)C3)ccn1 CHEMBL4207171 IC50 21.0 nM
COc1c(C#N)ccc(O[C@@H](C)C(F)(F)F)c1C(=O)N1Cc2cn(-c3ccc(F)cn3)nc2C1 CHEMBL4639407 IC50 21.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2OC(F)(F)F)(C2CCCCN2C)CC1 CHEMBL460922 IC50 21.2 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3ccccc3OC(F)(F)F)CCCCC2)CC1 CHEMBL2324161 IC50 22.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(F)cn2)CC1c1ccc(F)cc1 CHEMBL3898294 IC50 22.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cnc(C3CC3)nc2)CC1c1ccccc1F CHEMBL3970870 IC50 22.0 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3ccc(Cl)cc3Cl)CCCCC2)CC1 CHEMBL2324167 IC50 22.7 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3ccc(Cl)cc3Cl)CCCCC2)CC1 CHEMBL4565929 IC50 22.7 nM
O=C1NCN(c2ccccc2)C12CCN([C@H]1CCCC[C@H]1c1ccc(F)cc1)CC2 CHEMBL199888 EC50 23.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccc(F)cn2)CC1c1cccc(F)c1F CHEMBL3897626 IC50 23.0 nM
CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1Cc2cn(-c3ccccc3F)nc2C1 CHEMBL4213968 IC50 23.0 nM
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1Cc2cn(-c3cncc(F)c3)nc2C1)C(F)(F)F CHEMBL4206639 IC50 23.0 nM
Cc1cccc(-n2cc3c(n2)CN(C(=O)c2cc(S(C)(=O)=O)ccc2O[C@@H](C)C(F)(F)F)C3)c1 CHEMBL4206122 IC50 23.0 nM
CN1CC2CCC1([C@H](NC(=O)c1c(Cl)cccc1Cl)c1ccccc1)CC2 CHEMBL4225617 IC50 23.0 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3c(F)cccc3F)CCCCC2)CC1 CHEMBL2324477 IC50 23.2 nM
O=C1NCN(c2ccc(F)cc2)C12CCN([C@@H]1CCCC[C@@]1(O)c1ccc(Cl)cc1)CC2 CHEMBL372567 EC50 24.0 nM
O=C1NCN(c2ccc(F)cc2)C12CCN([C@@H]1CCCC[C@@]1(O)c1ccc(F)cc1)CC2 CHEMBL436295 EC50 24.0 nM
O=C1NCN(c2ccc(F)cc2)C12CCN([C@H]1CCCC[C@H]1c1ccccc1)CC2 CHEMBL370111 EC50 24.0 nM
O=C1NCN(c2ccccc2)C12CCN(C1CCCCC1(O)c1ccc(F)cc1)CC2 CHEMBL385360 EC50 24.0 nM
COc1cc(C(F)(F)F)cc(SC)c1C(=O)NC1(c2ccccc2)CCCN(C)C1 CHEMBL3259926 EC50 24.0 nM
Cc1cnc(N2CCN(C(=O)C3CCS(=O)(=O)CC3)C(c3ccccc3F)C2)nc1 CHEMBL3930759 IC50 24.0 nM
Cn1cnc(S(=O)(=O)N2C[C@H]([C@@H]3CCCO3)[C@@H](Nc3cccc(OC(F)(F)F)c3)C2)c1 CHEMBL4171068 Ki 24.0 nM
O=C1NCN(CCc2ccccc2)C12CCN([C@H]1CCCC[C@H]1c1ccccc1)CC2 CHEMBL373053 EC50 25.0 nM
O=C1NCN(CCC2CCCCC2)C12CCN([C@H]1CCCC[C@H]1c1ccccc1)CC2 CHEMBL371959 EC50 25.0 nM
CN(CCOc1ccc(-c2ccc3c(c2)OCCO3)cc1-c1cccs1)CC(=O)O CHEMBL401348 IC50 25.0 nM
CS(=O)(=O)c1ccc(C2CCCCC2)c(C(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)c1 CHEMBL523557 EC50 25.0 nM
O=C(CNC(=O)c1ccc(F)cc1)NC(c1ccccc1)c1cccc(C(F)(F)F)c1 CHEMBL479071 EC50 25.0 nM
Cn1cnc(S(=O)(=O)N2CC3CCC(NC(=O)c4ccc(Cl)cc4Cl)C3C2)c1 CHEMBL3115219 IC50 25.0 nM
COc1cc(C(F)(F)F)cc(SC)c1C(=O)NC1(c2cccc(Cl)c2)CCCN(C)C1 CHEMBL3259935 EC50 25.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cnc(C3CC3)nc2)CC1c1ccc(Cl)s1 CHEMBL3959818 IC50 25.0 nM
O=C1NCN(c2ccccc2)C12CCN([C@H]1CCCC[C@H]1c1ccccc1)CC2 CHEMBL383610 EC50 26.0 nM
O=C1NCN(c2ccccc2)C12CCN(C1CCCCC1c1ccccc1)CC2 CHEMBL377140 EC50 26.0 nM
CN(CCOc1ccc(-c2cccc(Cl)c2)cc1C(=O)c1cccs1)CC(=O)O CHEMBL249760 IC50 26.0 nM
CCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC2CC2)CC1 CHEMBL472757 IC50 26.0 nM
COc1cc(C(F)(F)F)cc(SC)c1C(=O)NC1(c2ccc(F)cc2)CCCN(C)C1 CHEMBL3259930 EC50 26.0 nM
COc1c(S(C)(=O)=O)ccc(O[C@@H](C)C(F)(F)F)c1C(=O)N1CC(c2ncc(C(F)(F)F)cc2F)C1 CHEMBL4634285 IC50 26.0 nM
CCCS(=O)(=O)N1CCC(CCOC)(CNC(=O)c2ccc(Cl)cc2Cl)CC1 CHEMBL464416 IC50 26.5 nM
OCC1(N2CCN(C3CCc4ccc(OCc5noc(-c6ccc(Cl)cc6)n5)cc43)CC2)CCCC1 CHEMBL392770 Ki 26.8 nM
Cn1cnc(C(=O)N(Cc2ccc(F)c(C(F)(F)F)c2)[C@@H]2C[C@H]3CNC[C@H]3C2)c1 CHEMBL607982 Ki 26.9 nM
O=C1NCN(c2ccc(Cl)cc2)C12CCN([C@H]1CCCC[C@H]1c1ccccc1)CC2 CHEMBL425929 EC50 27.0 nM
COc1ccc(-c2ccc(OCCN(C)CC(=O)O)c(C(=O)c3cccs3)c2)cc1 CHEMBL249969 IC50 27.0 nM
Cc1ccc(N2CCN(C(=O)C3CCS(=O)(=O)CC3)C(c3cccc(F)c3)C2)nc1 CHEMBL3954521 IC50 27.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cnc(C(F)(F)F)nc2)CC1c1ccc(Cl)s1 CHEMBL3939264 IC50 27.0 nM
CCS(=O)(=O)c1ccc(O[C@@H](C)C(F)(F)F)c(C(=O)N2Cc3cn(-c4cncc(F)c4)nc3C2)c1 CHEMBL4214756 IC50 27.0 nM
COc1c(S(C)(=O)=O)ccc(O[C@@H](C)C(F)(F)F)c1C(=O)N1CC(c2ccc(C(F)(F)F)cc2)C1 CHEMBL4646639 IC50 27.0 nM
CN(CCC1(c2ccccc2)C(=O)c2ccc(Cl)cc2C1=O)CC(=O)O CHEMBL203298 IC50 28.0 nM
COc1ccc(-c2ccc(OCCN(C)CC(=O)O)c(-c3ccccc3Cl)c2)cc1C CHEMBL251775 IC50 28.0 nM
CS(=O)(=O)c1ccc(OCC(F)(F)F)c(C(=O)N2CCN(c3ccc(C#N)cc3F)CC2)c1 CHEMBL1172998 EC50 28.0 nM
CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1Cc2ccc(C3CCOCC3)cc2C1 CHEMBL1631025 EC50 28.0 nM
Cn1cnc(S(=O)(=O)N2C[C@@H]3[C@H](C2)[C@@]3(CNC(=O)c2c(Cl)cccc2Cl)CC2CC2)c1 CHEMBL3114970 IC50 28.0 nM
COc1cc(C(F)(F)F)cc(SC)c1C(=O)NC1(c2ccc(Cl)cc2)CCCN(C)C1 CHEMBL3259931 EC50 28.0 nM
CCCS(=O)(=O)N[C@@H]1CCN(c2ccc3c(c2)[C@@H](Cc2ccccc2)[C@@H](N2CCC2)CC3)C1=O CHEMBL4159833 Ki 28.0 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3ccc(F)cc3C)CCCCC2)CC1 CHEMBL2324168 IC50 28.1 nM
CCn1cc(S(=O)(=O)N2CCC(CNC(=O)c3ccc(Cl)cc3Cl)(CC3CC3)CC2)nn1 CHEMBL483345 IC50 28.22 nM
CCS(=O)(=O)N1CCN(C2(CNC(=O)c3c(C)cc(F)cc3OC)CCC(F)(F)CC2)CC1 CHEMBL4455289 IC50 28.5 nM
CS(=O)(=O)c1ccc(-c2ccc(F)cc2)c(C(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)c1 CHEMBL496749 EC50 29.0 nM
Cc1ccc(S(=O)(=O)[C@H]2CC[C@@](CNC(=O)c3ccc(Cl)cc3Cl)(CC3CC3)CC2)nn1 CHEMBL2146714 IC50 29.0 nM
O=C(NC[C@]1(CC2CC2)CC[C@H](S(=O)(=O)CC2CC2)CC1)c1ccc(Cl)cc1Cl CHEMBL2146721 IC50 29.0 nM
Cn1cnc(S(=O)(=O)N2C[C@H](C(=O)c3cccc(OC(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2)c1 CHEMBL4172573 Ki 29.0 nM
CCS(=O)(=O)c1ccc(O[C@@H](C)C(F)(F)F)c(C(=O)N2Cc3cn(-c4ccccc4F)nc3C2)c1 CHEMBL4209849 IC50 29.0 nM
Cc1cccc(C(NC(=O)c2cccc(C(F)(F)F)c2Cl)C23CCC(CC2)CN3C)c1 CHEMBL4227651 IC50 29.0 nM
CCS(=O)(=O)N1CCN(C2(CNC(=O)c3c(Cl)cccc3OC(F)(F)F)CCC(F)(F)CC2)CC1 CHEMBL4451800 IC50 29.0 nM
N#Cc1ccc(N2CCN(C(=O)c3cc([N+](=O)[O-])ccc3N3CCOCC3)CC2)c(F)c1 CHEMBL496318 EC50 30.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC2CC2)CC1 CHEMBL462149 IC50 30.0 nM
CC(Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc(C(F)(F)F)cc2)CC1)C(F)(F)F CHEMBL1171499 EC50 30.0 nM
CC(Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ncc(C(F)(F)F)cc2Cl)CC1)C(F)(F)F CHEMBL1169701 EC50 30.0 nM
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ncc(C(F)(F)F)cc2F)CC1)C(C)(C)C CHEMBL2021600 EC50 30.0 nM
CS(=O)(=O)c1ccc(-c2ccc(F)c(F)c2)c(C(=O)N2Cc3cc(C(F)(F)F)cnc3C2)c1 CHEMBL1631199 EC50 30.0 nM
CC(C)COc1ccc(S(C)(=O)=O)cc1C(=O)N1Cc2cc(C(F)(F)F)cnc2C1 CHEMBL1631026 EC50 30.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cnc(C(F)(F)F)cn2)CC1c1ccc(F)cc1F CHEMBL3940022 IC50 30.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2nnc(C(F)(F)F)o2)CC1c1ccc(F)s1 CHEMBL3900639 IC50 30.0 nM
CS(=O)(=O)c1ccc(-c2ccccc2)c(C(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)c1 CHEMBL496540 EC50 31.0 nM
Cc1cnc(C2CN(c3ccc(C(F)(F)F)cn3)CCN2C(=O)C2CCS(=O)(=O)CC2)s1 CHEMBL3969584 IC50 31.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cccc(C(F)(F)F)c2)CC1c1ccccc1 CHEMBL3889991 IC50 31.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2C(F)(F)F)(c2ccccn2)CC1 CHEMBL465426 IC50 31.3 nM
Cn1cc(S(=O)(=O)N2CCC(CNC(=O)c3ccc(Cl)cc3Cl)(CC3CC3)CC2)nn1 CHEMBL484179 IC50 32.0 nM
Cn1cnc(S(=O)(=O)N2C[C@@H]3[C@H](C2)[C@@]3(CNC(=O)c2ccc(Cl)cc2)CC2CC2)c1 CHEMBL3114791 IC50 32.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2nnc(C(F)(F)F)s2)CC1c1ccccc1F CHEMBL3962388 IC50 32.0 nM
Cc1ccc2nc(N3CCN(C(=O)C4CCS(=O)(=O)CC4)C(c4ccccc4)C3)[nH]c2c1 CHEMBL3897710 IC50 32.0 nM
N[C@H]1CCc2ccc(OCCNS(=O)(=O)C3CCC3)cc2[C@H]1Cc1ccc(Cl)c(Cl)c1 CHEMBL4169708 Ki 32.0 nM
O=C(c1cc([N+](=O)[O-])ccc1N1CCOCC1)N1CCN(c2ccc(C(F)(F)F)c(Cl)n2)CC1 CHEMBL498380 EC50 33.0 nM
O=C(CNC(=O)c1ccc(F)cc1)NC(c1ccccc1)c1cccc(Cl)c1 CHEMBL518287 EC50 33.0 nM
C[C@H](Oc1ccc(C#N)c(Cl)c1C(=O)N1Cc2cn(-c3ccc(F)cn3)nc2C1)C(F)(F)F CHEMBL4644636 IC50 33.0 nM
CCCCCN1CNC(=O)C12CCN([C@H]1CCCC[C@H]1c1ccccc1)CC2 CHEMBL200728 EC50 34.0 nM
CN(CCOc1ccc(-c2ccc3c(c2)OCO3)cc1-c1cccs1)CC(=O)O CHEMBL401191 IC50 34.0 nM
CCCOc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc(C#N)cc2F)CC1 CHEMBL1173633 EC50 34.0 nM
COc1cccc(N2CCN(C(=O)C3CCS(=O)(=O)CC3)C(c3ccccc3)C2)c1 CHEMBL3954331 IC50 34.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(F)cn2)CC1c1cccc(F)c1 CHEMBL3944235 IC50 35.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cccc(Cl)c2)CC1c1ccccc1 CHEMBL3979865 IC50 35.0 nM
CCCS(=O)(=O)NCCOc1ccc2c(c1)[C@@H](Cc1ccc(Cl)c(Cl)c1)[C@@H](N)CC2 CHEMBL4176494 Ki 35.0 nM
O=C1NC[C@H](c2ccc(F)cc2)C12CCN([C@@H]1CCCC[C@@H]1c1ccc(F)cc1)CC2 CHEMBL378330 EC50 36.0 nM
Cc1ccc(C2CN(c3ccc(C(F)(F)F)nn3)CCN2C(=O)C2CCS(=O)(=O)CC2)s1 CHEMBL3906226 IC50 36.0 nM
CCS(=O)(=O)N1CCN(C2(CNC(=O)c3ccc(Cl)cc3Cl)CCC(F)(F)CC2)CC1 CHEMBL4455686 IC50 36.4 nM
CCCS(=O)(=O)[C@H]1CC[C@](CNC(=O)c2ccc(Cl)cc2Cl)(CC2CC2)CC1 CHEMBL2146715 IC50 36.9 nM
O=C(c1cc([N+](=O)[O-])ccc1N1CCOCC1)N1CCN(c2ccc(C(F)(F)F)c(F)c2)CC1 CHEMBL498182 EC50 37.0 nM
CC(Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc(C(F)(F)F)cn2)CC1)C(F)(F)F CHEMBL1170071 EC50 37.0 nM
Cc1cnc(N2CCN(C(=O)C3CCS(=O)(=O)CC3)C(c3ccc(F)cc3)C2)nc1 CHEMBL3977564 IC50 37.0 nM
Cc1ccc(N2CCN(C(=O)C3CCS(=O)(=O)CC3)C(c3ccc(F)cc3)C2)nc1 CHEMBL3977723 IC50 38.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2nnc(C(F)(F)F)s2)CC1c1ccc(F)cc1 CHEMBL3944314 IC50 38.0 nM
CS(=O)(=O)c1ccc(OCC2CC2)c(C(=O)N2Cc3cn(-c4ccccc4F)nc3C2)c1 CHEMBL4211426 IC50 38.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(N2CCC2)CC1 CHEMBL462148 IC50 38.1 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2Cl)(c2cc(C)ccn2)CC1 CHEMBL465427 IC50 38.3 nM
CCS(=O)(=O)N1CCN(C2(CNC(=O)c3ccc(F)cc3Cl)CCC(F)(F)CC2)CC1 CHEMBL4533944 IC50 38.4 nM
CC(=O)c1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3OC(C)C)CC2)c(F)c1 CHEMBL521898 EC50 39.0 nM
Cn1cnc(S(=O)(=O)N2CC([C@H](NC(=O)c3ccc(Cl)cc3Cl)c3ccccn3)C2)c1 CHEMBL3115206 IC50 39.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccc(C3CC3)nc2)CC1c1ccc(F)cc1 CHEMBL3907655 IC50 39.0 nM
CN1CC2CCC1(C(NC(=O)c1cccc(C(F)(F)F)c1Cl)c1ccccc1)CC2 CHEMBL4229103 IC50 39.0 nM
O=C1NCN(c2ccccc2)C12CCN([C@@H]1CCCC[C@@]1(O)c1ccc(F)cc1)CC2 CHEMBL425753 EC50 40.0 nM
O=C1NCN(c2ccccc2)C12CCN([C@H]1CCCC[C@H]1c1ccc(Cl)cc1)CC2 CHEMBL413714 EC50 40.0 nM
CN(CCOc1ccc(-c2ccccc2)cc1Cc1cccs1)CC(=O)O CHEMBL250372 IC50 40.0 nM
CS(=O)(=O)c1ccc(N2CCN(C(=O)c3cc([N+](=O)[O-])ccc3N3CCOCC3)CC2)c(F)c1 CHEMBL496319 EC50 40.0 nM
CS(=O)(=O)c1ccc(OCC2CC2)c(C(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)c1 CHEMBL521899 EC50 40.0 nM
CC(Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ncc(C(F)(F)F)cc2F)CC1)C(F)(F)F CHEMBL1171649 EC50 40.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccc(F)cn2)CC1c1cccc(F)c1 CHEMBL3907326 IC50 40.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cnc(C(F)(F)F)nc2)CC1c1ccccc1F CHEMBL3919769 IC50 40.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cnc(C(F)(F)F)cn2)CC1c1cccc(F)c1 CHEMBL3932086 IC50 40.0 nM
O=C(c1cc([N+](=O)[O-])ccc1N1CCOCC1)N1CCN(c2ccc(C(F)(F)F)cc2F)CC1 CHEMBL495916 EC50 41.0 nM
Cc1cnc(N2CCN(C(=O)C3CCS(=O)(=O)CC3)C(c3ccc(F)cc3)C2)cn1 CHEMBL3926433 IC50 41.0 nM
CN1CC2CCC1([C@@H](NC(=O)c1cccc(C(F)(F)F)c1Cl)c1ccccc1)CC2 CHEMBL4228770 IC50 41.0 nM
Cn1cnc(S(=O)(=O)N2CC(Nc3cccc(Cl)c3)C(c3cccc(F)c3)C2)c1 CHEMBL4175269 Ki 42.0 nM
CCS(=O)(=O)N1CCN(C2(CNC(=O)c3c(Cl)cccc3Cl)CCC(F)(F)CC2)CC1 CHEMBL4550823 IC50 42.4 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(C(F)(F)F)cc2F)(C(=O)N2CCOCC2)CC1 CHEMBL223492 IC50 42.8 nM
O=C1NC[C@@H](c2ccc(F)cc2)C12CCN([C@@H]1CCCC[C@@H]1c1ccc(F)cc1)CC2 CHEMBL378686 EC50 43.0 nM
O=C(N[C@@H](c1ccccc1)[C@@H]1CCCCN1)c1cccc(C(F)(F)F)c1I CHEMBL1939496 IC50 43.0 nM
COc1c(S(C)(=O)=O)ccc(O[C@@H](C)C(F)(F)F)c1C(=O)N1CC(c2ccc(C(F)(F)F)cn2)C1 CHEMBL4638896 IC50 43.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2cc(F)cc(F)c2Cl)(C2CCCCN2C)CC1 CHEMBL463226 IC50 43.1 nM
O=C1NCN(c2ccccc2)C12CCN([C@@H]1CCCC[C@@]1(O)c1ccccc1)CC2 CHEMBL200204 EC50 44.0 nM
O=C1NCN(c2ccccc2)C12CCN(C1CCCCC1(O)c1ccccc1)CC2 CHEMBL211373 EC50 44.0 nM
CC(Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc(C#N)cc2F)CC1)C(F)(F)F CHEMBL1172999 EC50 44.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccc3ccccc3c2)CC1c1cccs1 CHEMBL3914072 IC50 44.0 nM
CCCS(=O)(=O)NC1CN(c2ccc3c(c2)[C@@H](Cc2ccccc2)[C@@H](N2CCC2)CO3)C1 CHEMBL4167754 Ki 44.0 nM
CN(CCOc1ccc(-c2ccccc2)cc1C(=O)c1cccs1)CC(=O)O CHEMBL400396 IC50 45.0 nM
Cc1cccc(-c2ccc(OCCN(C)CC(=O)O)c(C(=O)c3cccs3)c2)c1 CHEMBL249762 IC50 45.0 nM
CS(=O)(=O)c1ccc(N2CCOCC2)c(C(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)c1 CHEMBL496532 EC50 45.0 nM
Cc1cccc(C)c1C(=O)NC(c1ccncc1)C12CCC(CC1)N2 CHEMBL4225903 IC50 45.0 nM
CN1CC2CCC1([C@H](NC(=O)c1c(Cl)cncc1Cl)c1ccccc1)CC2 CHEMBL4225742 IC50 45.0 nM
CS(=O)(=O)c1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3N3CCCCC3)CC2)c(F)c1 CHEMBL522914 EC50 46.0 nM
Cc1cnc(N2CCN(C(=O)C3CCS(=O)(=O)CC3)C(c3cccc(F)c3)C2)cn1 CHEMBL3916722 IC50 46.0 nM
O=C(c1cc([N+](=O)[O-])ccc1N1CCOCC1)N1CCN(c2ncc(C(F)(F)F)cc2Cl)CC1 CHEMBL521736 EC50 47.0 nM
Cc1cnc(C2CN(c3cnc(C(F)(F)F)cn3)CCN2C(=O)C2CCS(=O)(=O)CC2)s1 CHEMBL3951680 IC50 47.0 nM
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ncc(C(F)(F)F)cc2F)CC1)C(F)(F)F CHEMBL1171829 Ki 47.0 nM
O=C1NCC(c2ccccc2)C12CCN(C1CCCCC1c1ccc(F)cc1)CC2 CHEMBL378616 EC50 48.0 nM
COc1cc(C(F)(F)F)cc(SC)c1C(=O)NC1(c2cccc(F)c2)CCCN(C)C1 CHEMBL3259934 EC50 48.0 nM
Cc1cnc(N2CCN(C(=O)C3CCS(=O)(=O)CC3)C(c3ccccc3F)C2)cn1 CHEMBL3932663 IC50 48.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2)(c2cccc(OC)n2)CC1 CHEMBL465129 IC50 48.3 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3ccccc3C(F)(F)F)CCCCC2)CC1 CHEMBL2324160 IC50 48.5 nM
CCCCCCN1CNC(=O)C12CCN([C@H]1CCCC[C@H]1c1ccccc1)CC2 CHEMBL200694 EC50 49.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccc(F)cn2)CC1c1ccccc1F CHEMBL3986409 IC50 49.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cccc(C(F)(F)F)c2)CC1c1cccs1 CHEMBL3942068 IC50 49.0 nM
Cn1cnc(S(=O)(=O)N2C[C@H](Nc3cccc(C#N)c3)[C@@H](c3ccccc3)C2)c1 CHEMBL4172641 Ki 49.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2F)(c2ccccn2)CC1 CHEMBL463478 IC50 49.4 nM
Cc1ccccc1[C@]1(O)CCCC[C@H]1N1CCC2(CC1)C(=O)NCN2c1ccccc1 CHEMBL381419 EC50 50.0 nM
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1Cc2cc(C(F)(F)F)cnc2C1)C(F)(F)F CHEMBL1631017 EC50 50.0 nM
CS(=O)(=O)c1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3OCC3CC3)CC2)c(F)c1 CHEMBL523567 EC50 52.0 nM
CN(CCOc1ccc(-c2ccccc2)cc1-c1ccccc1Cl)CC(=O)O CHEMBL404856 IC50 53.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(F)cn2)CC1c1ccccc1F CHEMBL3907787 IC50 53.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cnc(C3CC3)nc2)CC1c1cccc(F)c1 CHEMBL3926797 IC50 53.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cnc(C(F)(F)F)nc2)CC1c1ccc(F)cc1 CHEMBL3944153 IC50 53.0 nM
COc1cc(C(F)(F)F)cc(SC)c1C(=O)NC1(c2cccnc2)CCCN(C)C1 CHEMBL3259937 EC50 54.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2)(c2cccc(C)n2)CC1 CHEMBL463238 IC50 54.7 nM
Cc1ccc(N2CNC(=O)C23CCN([C@H]2CCCC[C@H]2c2ccccc2)CC3)cc1 CHEMBL371002 EC50 55.0 nM
Cc1cc(-n2cc3c(n2)CN(C(=O)c2cc(C#N)ccc2-c2cccc(F)c2)C3)ccn1 CHEMBL4212425 IC50 55.0 nM
O=C1NCN(c2ccccc2)C12CCN([C@H]1CCCC[C@@]1(O)c1ccccc1)CC2 CHEMBL200371 EC50 56.0 nM
O=C1NCC(c2ccc(F)cc2)C12CCN(C1(c3ccc(F)cc3)CCCCC1)CC2 CHEMBL534940 EC50 56.0 nM
Cc1ccccc1-c1cc(-c2ccccc2)ccc1OCCN(C)CC(=O)O CHEMBL248920 IC50 56.0 nM
Cc1cccc(C(NC(=O)CNC(=O)c2ccc(F)cc2)c2ccccc2)c1 CHEMBL479084 EC50 56.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncccn2)CC1c1cccc(F)c1F CHEMBL3986473 IC50 56.0 nM
O=C(NCC1(N2CCN(S(=O)(=O)CC3CC3)CC2)CCCCC1)c1ccc(Cl)cc1Cl CHEMBL4536223 IC50 56.6 nM
CS(=O)(=O)c1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3-c3ccccc3)CC2)c(F)c1 CHEMBL495939 EC50 57.0 nM
CCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(c2ccccn2)CC1 CHEMBL461987 IC50 57.0 nM
C[C@@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ncc(C(F)(F)F)cc2F)CC1)C(C)(C)C CHEMBL2021601 EC50 57.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(F)cn2)CC1c1cccc(F)c1F CHEMBL3911292 IC50 57.0 nM
O=C1NCN(c2ccccc2)C12CCN([C@@H]1COCC[C@@]1(O)c1ccccc1)CC2 CHEMBL201226 EC50 58.0 nM
Cc1cccc(C)c1C(=O)NC(c1ccccc1)C12CCC(CC1)N2 CHEMBL4227145 IC50 58.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2Cl)(C2CCCCN2C)CC1 CHEMBL461802 IC50 58.9 nM
O=C(O)[C@@H]1CCCN1CCOc1ccc(-c2ccccc2)cc1Sc1cccc(F)c1 CHEMBL214033 IC50 59.0 nM
Cc1ccc(-c2ccc(OCCN(C)CC(=O)O)c(C(=O)c3cccs3)c2)cc1 CHEMBL249968 IC50 59.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cc(C(F)(F)F)on2)CC1c1ccc(C(F)(F)F)s1 CHEMBL3971897 IC50 59.0 nM
COc1cc(C(F)(F)F)cc(SC)c1C(=O)NC1(c2ccncc2)CCCN(C)C1 CHEMBL3259938 EC50 60.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccccn2)CC1c1ccc(F)c(F)c1 CHEMBL3944701 IC50 60.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccccn2)CC1c1ccccc1F CHEMBL3978303 IC50 60.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cnc(C(F)(F)F)nc2)CC1c1cccc(F)c1 CHEMBL3944635 IC50 60.0 nM
Cn1cnc(S(=O)(=O)N2C[C@H](CNc3cccc(OC(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2)c1 CHEMBL4177049 Ki 60.0 nM
O=C1NC[C@H](c2ccccc2)C12CCN([C@H]1CCCC[C@H]1c1ccccc1)CC2 CHEMBL386658 EC50 61.0 nM
O=C1NC[C@@H](c2ccccc2)C12CCN(C1CCCCC1c1ccccc1)CC2 CHEMBL2096837 EC50 61.0 nM
OCC1(N2CCN(C3CCc4ccc(OCc5noc(-c6ccccc6F)n5)cc43)CC2)CCCC1 CHEMBL239601 Ki 61.4 nM
O=C1NCN(c2ccccc2)C12CCN([C@@H]1CCCC[C@@]1(O)c1ccncc1)CC2 CHEMBL372995 EC50 62.0 nM
CCCC1CNC(=O)C12CCN(C1(c3ccccc3)CCCCC1)CC2 CHEMBL213683 EC50 62.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(F)cn2)CC1c1ccc(F)c(F)c1 CHEMBL3969969 IC50 62.0 nM
O=C(CN(C(=O)c1ccc(-c2ccccn2)cc1)C1CCCCC1)Nc1cc(F)cc(F)c1 CHEMBL1835891 pIC50 63.1 nM
O=C(CN(C(=O)c1ccc(-c2ccccn2)cc1)C1CCCC1)Nc1cc(F)cc(F)c1 CHEMBL1834679 pIC50 63.1 nM
Cn1cnc(S(=O)(=O)N2C[C@@H]3[C@H](C2)[C@@]3(CNC(=O)c2cccc(C(F)(F)F)c2)CC2CC2)c1 CHEMBL3114972 IC50 64.0 nM
O=C1NCN(CC2CCCCC2)C12CCN([C@H]1CCCC[C@H]1c1ccccc1)CC2 CHEMBL383438 EC50 65.0 nM
O=C1NCN(c2ccc(C(F)(F)F)cc2)C12CCN([C@H]1CCCC[C@H]1c1ccccc1)CC2 CHEMBL200921 EC50 65.0 nM
CN(CCOc1ccc(-c2ccccc2)cc1C(=O)c1ccccc1)CC(=O)O CHEMBL401422 IC50 65.0 nM
COc1ccc(N2CNC(=O)C23CCN([C@H]2CCCC[C@H]2c2ccccc2)CC3)cc1 CHEMBL200145 EC50 66.0 nM
Fc1ccccc1-c1nc(COc2ccc3c(c2)C(N2CCN(C4CCCC4)CC2)CC3)no1 CHEMBL393168 Ki 66.8 nM
O=C1NCN(c2ccccc2)C12CCN([C@H]1CCCC[C@H]1c1ccc(Cl)c(Cl)c1)CC2 CHEMBL383141 EC50 67.0 nM
O=C1NCC(c2ccc(F)cc2)C12CCN(C1(c3cccs3)CCCCC1)CC2 CHEMBL556163 EC50 67.0 nM
CSc1cc(C(F)(F)F)ccc1C(=O)NC1(c2ccccc2)CCCN(C)C1 CHEMBL3259925 EC50 67.0 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3c(F)cccc3F)CCC(F)(F)CC2)CC1 CHEMBL2324491 IC50 67.5 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(F)cc2C(F)(F)F)(C(=O)N2CCOCC2)CC1 CHEMBL223596 IC50 67.8 nM
CN(CCOc1ccc(-c2ccc(Cl)cc2)cc1C(=O)c1cccs1)CC(=O)O CHEMBL399959 IC50 68.0 nM
O=C1NCC(c2ccc(F)cc2)C12CCN(C1CCCCC1(O)c1ccccc1F)CC2 CHEMBL214050 EC50 69.0 nM
Cc1ccccc1C1(O)CCCCC1N1CCC2(CC1)C(=O)NCC2c1ccc(F)cc1 CHEMBL378722 EC50 69.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(C(=O)NCC2(C)COC2)CC1 CHEMBL223677 IC50 69.0 nM
CC(=O)c1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3-c3ccccc3)CC2)c(F)c1 CHEMBL497790 EC50 69.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(F)cn2)CC1c1ccc(F)cc1F CHEMBL3953233 IC50 69.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccc(C(F)(F)F)cn2)C[C@@H]1c1ccc(F)cc1 CHEMBL4109203 IC50 69.0 nM
Cn1cnc(S(=O)(=O)NCCOc2ccc3c(c2)[C@@H](Cc2ccccc2)[C@@H](NCC(F)(F)F)CC3)c1 CHEMBL4176035 Ki 69.0 nM
C[C@H](Oc1ccc(C#N)cc1C(=O)N1Cc2cn(-c3cncc(F)c3)nc2C1)C(F)(F)F CHEMBL4205726 IC50 69.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(c2cccnc2)CC1 CHEMBL460538 IC50 69.3 nM
O=C1NCC(c2ccccc2)C12CCN(C1CCCCC1(O)c1ccc(F)cc1)CC2 CHEMBL214122 EC50 70.0 nM
CN(CCOc1ccc(-c2ccccc2)cc1C(=O)C1CCCCC1)CC(=O)O CHEMBL250581 IC50 70.0 nM
CN(CCOc1ccc(-c2ccccc2)cc1-c1cccs1)CC(=O)O CHEMBL250373 IC50 70.0 nM
CC(=O)c1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3N3CCOCC3)CC2)c(F)c1 CHEMBL526648 EC50 70.0 nM
CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc(C#N)cc2F)CC1 CHEMBL1173635 EC50 70.0 nM
CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1Cc2cc(C(F)(F)F)cnc2C1 CHEMBL1631024 EC50 70.0 nM
CCCS(=O)(=O)NCc1ccc2c(c1)[C@@H](Cc1ccccc1)[C@@H](N1CCC1)CC2 CHEMBL4160909 Ki 71.0 nM
O=C1NCN(c2ccccc2)C12CCN(C1(c3ccccc3)CCCCC1)CC2 CHEMBL403515 EC50 72.0 nM
O=C1NCN(c2ccccc2)C12CCN([C@@H]1CCCC[C@H]1c1ccccc1)CC2 CHEMBL371267 EC50 73.0 nM
Cc1ccc(C2CNC(=O)C23CCN(C2(c4ccc(F)cc4)CCCCC2)CC3)cc1 CHEMBL212441 EC50 73.0 nM
O=C1NCC(c2ccc(F)cc2)C12CCN(C1CCCCC1(O)c1cccc(Cl)c1)CC2 CHEMBL386977 EC50 73.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncccn2)CC1c1ccc(F)cc1 CHEMBL3919912 IC50 73.0 nM
CCS(=O)(=O)N1CCN(C2(CNC(=O)c3c(N)cccc3Cl)CCCCC2)CC1 CHEMBL4580509 IC50 73.8 nM
CS(=O)(=O)c1ccc(N2CCCCC2)c(C(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)c1 CHEMBL496533 EC50 75.0 nM
Cn1cnc(S(=O)(=O)NCCOc2ccc3c(c2)[C@@H](Cc2ccccc2Cl)[C@@H](N)CC3)c1 CHEMBL4177029 Ki 75.0 nM
CN1CC2CCC1([C@H](NC(=O)c1ccncc1Br)c1ccccc1)CC2 CHEMBL4225649 IC50 75.0 nM
Cc1ccc(-c2ccc(OCCN(C)CC(=O)O)c(C(=O)c3cccs3)c2)cc1C CHEMBL249970 IC50 76.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncccn2)CC1c1ccccc1F CHEMBL3977226 IC50 76.0 nM
O=C1NCC(c2ccc(F)cc2)C12CCN(C1CCCCC1(O)c1cccc(F)c1)CC2 CHEMBL379938 EC50 77.0 nM
O=C1NCC(c2ccccc2)C12CCN(C1(c3ccccc3)CCCCC1)CC2 CHEMBL377164 EC50 77.0 nM
CN(C)S(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(c2ccccn2)CC1 CHEMBL463224 IC50 77.0 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3cccc(C(F)(F)F)c3Cl)CCCCC2)CC1 CHEMBL2324165 IC50 77.9 nM
N#Cc1ccc(N2CCN(C(=O)c3cc([N+](=O)[O-])ccc3N3CCOCC3)CC2)cc1 CHEMBL526079 EC50 78.0 nM
C[C@H](Oc1ccc(C#N)cc1C(=O)N1Cc2cn(-c3ccccc3F)nc2C1)C(F)(F)F CHEMBL4210589 IC50 78.0 nM
CN1CC2CCC1(C(NC(=O)c1cccc(C(F)(F)F)c1Cl)c1ccco1)CC2 CHEMBL4227172 IC50 78.0 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3ccc(Cl)cc3Cl)CCOCC2)CC1 CHEMBL2324488 IC50 78.4 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(c2ccncc2)CC1 CHEMBL460539 IC50 79.3 nM
O=C(CN(C(=O)c1ccc(N2CCCC2)cc1)C1CCCCC1)Nc1cc(F)cc(F)c1 CHEMBL1835890 pIC50 79.43 nM
O=C(CN(C(=O)c1ccc(-c2ccccn2)cc1)C1CCCOC1)Nc1cc(F)cc(F)c1 CHEMBL1834681 pIC50 79.43 nM
O=C1NCN(c2ccccc2)C12CCN([C@@H]1CCCC[C@@]1(O)c1ccc(Cl)cc1)CC2 CHEMBL373170 EC50 80.0 nM
CC(Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc(C(F)(F)F)nc2)CC1)C(F)(F)F CHEMBL1171469 EC50 80.0 nM
Cc1cc(C(F)(F)F)cnc1N1CCN(C(=O)c2cc(S(C)(=O)=O)ccc2OC(C)C(F)(F)F)CC1 CHEMBL1171650 EC50 80.0 nM
O=C(N[C@@H](c1ccccc1)[C@@H]1CCCCN1)c1cccc(C(F)(F)F)c1Cl CHEMBL1739063 IC50 80.1 nM
CCCC1CNC(=O)C12CCN(C1(c3ccccc3)CCCCC1)CC2 CHEMBL540110 EC50 82.0 nM
CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc(C(F)(F)F)cc2)CC1 CHEMBL524645 EC50 82.0 nM
Cn1cnc(S(=O)(=O)N2C[C@@H]3[C@H](C2)[C@@]3(CNC(=O)c2ccc(Cl)c(Cl)c2)CC2CC2)c1 CHEMBL3114789 IC50 82.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2nnc(C(F)(F)F)s2)C[C@@H]1c1ccc(Cl)s1 CHEMBL4113843 IC50 83.0 nM
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1Cc2ccc(-c3ccccn3)cc2C1)C(F)(F)F CHEMBL1631020 EC50 84.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncccn2)CC1c1cccc(F)c1 CHEMBL3916216 IC50 84.0 nM
Cc1ccc([C@@H]2CCCC[C@@H]2N2CCC3(CC2)C(=O)NCN3c2ccccc2)cc1 CHEMBL371906 EC50 85.0 nM
CN(CCC1(c2ccccc2)C(=O)c2cccc(F)c2C1=O)CC(=O)O CHEMBL205828 IC50 85.0 nM
CN(CCOc1ccc(-c2ccccc2)cc1Cc1ccccc1)CC(=O)O CHEMBL250374 IC50 85.0 nM
CCN(Cc1cccc(OCc2noc(-c3ccccc3F)n2)c1)C1CCN(C2CC(C)C(C)C2)C1 CHEMBL392350 Ki 85.3 nM
CC(O)CS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(c2ccccn2)CC1 CHEMBL461108 IC50 86.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C(F)(F)F)cn2)C[C@@H]1c1ccc(Cl)s1 CHEMBL4114990 IC50 87.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2nnc(C(F)(F)F)s2)C[C@H]1c1ccc(C(F)(F)F)s1 CHEMBL3897761 IC50 87.0 nM
O=C(CNC(=O)c1ccc(F)cc1)NC(c1ccccc1)c1ccc(Cl)cc1 CHEMBL475926 EC50 88.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2OC(F)(F)F)(C(=O)N2CCOCC2)CC1 CHEMBL220987 IC50 88.4 nM
O=C(CNC(=O)c1ccsc1)NC(c1ccccc1)c1ccc(Cl)cc1 CHEMBL476360 EC50 89.0 nM
O=C1NCN(c2ccccc2)C12CCN([C@@H]1CCOC[C@@]1(O)c1ccccc1)CC2 CHEMBL200053 EC50 90.0 nM
O=C1NCC(c2ccc(F)cc2)C12CCN(C1CCCCC1c1ccc(C(F)(F)F)cc1)CC2 CHEMBL213672 EC50 91.0 nM
O=C1NCC(c2ccc(F)cc2)C12CCN(C1CCCCC1(O)c1ccccc1)CC2 CHEMBL378253 Activity 91.0 nM
CC(=O)c1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3OC(C)C(F)(F)F)CC2)cc1 CHEMBL1171995 EC50 91.0 nM
CN1CC2CCC1([C@H](NC(=O)c1ccnc(C(F)(F)F)c1F)c1ccccc1)CC2 CHEMBL4226396 IC50 92.0 nM
CCCC1CNC(=O)C12CCN(C1(c3ccc(F)cc3)CCCCC1)CC2 CHEMBL214057 EC50 93.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncccn2)CC1c1ccc(F)cc1F CHEMBL3931004 IC50 93.0 nM
Cn1cnc(S(=O)(=O)N2C[C@H](Cc3ccccc3)[C@@H](c3ccccc3)C2)c1 CHEMBL4169188 Ki 93.0 nM
O=C1NCC(c2ccc(F)cc2)C12CCN(C1(c3ccc(F)cc3)CCCCC1)CC2 CHEMBL377114 EC50 95.0 nM
Cn1cnc(C(=O)N(Cc2cccc(Cl)c2)C[C@H]2[C@@H]3CNC[C@@H]32)c1 CHEMBL565142 Ki 95.3 nM
Cn1cnc(S(=O)(=O)N2C[C@H](Oc3cc(C(F)(F)F)ncn3)[C@@H](c3ccc(F)cc3)C2)c1 CHEMBL4173675 Ki 97.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccccn2)CC1c1cccc(F)c1F CHEMBL3920227 IC50 98.0 nM
COc1ccc(N2CNC(=O)C23CCN([C@@H]2CCCC[C@@]2(O)c2ccc(Cl)cc2)CC3)cc1 CHEMBL200621 EC50 99.0 nM
O=C1NCC(c2ccc(F)cc2)C12CCN(C1(c3ccsc3)CCCCC1)CC2 CHEMBL379111 EC50 99.0 nM
O=C1NCC(c2ccc(F)cc2)C12CCN(C1(c3ccsc3)CCCCC1)CC2 CHEMBL537203 EC50 99.0 nM
CN(CCC(Oc1ccc(C(F)(F)F)cc1)c1ccc(Cl)cc1)CC(=O)[O-] CHEMBL59858 Log IC50 100.0 nM
CC[C@H]1CCCCN1C[C@@H](O)CNS(=O)(=O)c1cccc2ccccc12 CHEMBL241288 Log IC50 100.0 nM
CNS(=O)(=O)c1ccc(N2CCOCC2)c(C(=O)N2CCN(c3ccc(C(C)=O)cc3F)CC2)c1 CHEMBL497970 EC50 100.0 nM
O=C(c1cc([N+](=O)[O-])ccc1N1CCOCC1)N1CCN(c2ccc(C(F)(F)F)cc2)CC1 CHEMBL525726 EC50 100.0 nM
CC(Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc(S(C)(=O)=O)cc2)CC1)C(F)(F)F CHEMBL1173500 EC50 100.0 nM
CC(Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ncc(C(F)(F)F)cn2)CC1)C(F)(F)F CHEMBL1171471 EC50 100.0 nM
CC(C)CN(CC(=O)Nc1cc(F)cc(F)c1)C(=O)c1ccc(-c2ccccn2)cc1 CHEMBL1835899 pIC50 100.0 nM
Cn1cnc(S(=O)(=O)N2C[C@@H]3[C@H](C2)[C@@]3(CNC(=O)c2cc(Cl)cc(Cl)c2)CC2CC2)c1 CHEMBL3114790 IC50 100.0 nM
COc1ccc2c(c1)CC[C@H](CN(C)CC(=O)O)[C@@H]2c1ccccc1 CHEMBL4228124 IC50 100.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccccn2)CC1c1ccc(F)cc1 CHEMBL3893372 IC50 101.0 nM
CN(CCC1(c2ccccc2)C(=O)c2ccccc2C1=O)CC(=O)O CHEMBL204286 IC50 103.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2)(c2ccccn2)CC1 CHEMBL464621 IC50 103.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccccn2)CC1c1ccc(F)cc1F CHEMBL3934609 IC50 103.0 nM
COc1cccc(-c2ccc(OCCN(C)CC(=O)O)c(C(=O)c3cccs3)c2)c1 CHEMBL399960 IC50 104.0 nM
CC(C)Oc1ccc(C#N)cc1C(=O)N1Cc2cn(-c3ccccc3)nc2C1 CHEMBL4202824 IC50 105.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2)(c2ccccn2)CC1 CHEMBL518686 IC50 107.0 nM
OCC1(NCCCC2CCc3ccc(OCc4noc(-c5ccc(Cl)cc5)n4)cc32)CCCC1 CHEMBL393169 Ki 108.0 nM
CN(CCOc1ccc(-c2ccccc2)cc1-c1ccccc1F)CC(=O)O CHEMBL251150 IC50 108.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(C(=O)N2CC(N)C2)CC1 CHEMBL223491 IC50 109.0 nM
Cn1cnc(C(=O)N(Cc2ccc(F)c(Cl)c2)C[C@H]2[C@@H]3CNC[C@@H]32)c1 CHEMBL560289 Ki 109.0 nM
O=C1NCN(c2ccccc2)C12CCN([C@@H]1CCCC[C@@]1(O)c1cccnc1)CC2 CHEMBL200695 EC50 110.0 nM
CS(=O)(=O)c1ccc(N2CCN(C(=O)c3cc([N+](=O)[O-])ccc3N3CCOCC3)CC2)cc1 CHEMBL496115 EC50 110.0 nM
O=C(CNC(=O)c1ccc(F)cc1)NC(c1ccccc1)c1ccccc1 CHEMBL476568 EC50 110.0 nM
CC(Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2cnc(C(F)(F)F)cn2)CC1)C(F)(F)F CHEMBL1171470 EC50 110.0 nM
COc1cccc(C2(NC(=O)c3c(OC)cc(C(F)(F)F)cc3SC)CCCN(C)C2)c1 CHEMBL3259936 EC50 110.0 nM
CS(=O)(=O)c1ccc(OCCC(F)(F)F)c(C(=O)N2Cc3cc(C(F)(F)F)cnc3C2)c1 CHEMBL1631197 EC50 111.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cnc(C(F)(F)F)cn2)C[C@@H]1c1ccc(F)cc1 CHEMBL4111473 IC50 112.0 nM
CCCC1CNC(=O)C12CCN(C1(c3ccc(C)s3)CCCCC1)CC2 CHEMBL386703 EC50 113.0 nM
COc1ccc(C2CNC(=O)C23CCN(C2CCCCC2c2ccc(F)cc2)CC3)cc1 CHEMBL213809 EC50 113.0 nM
CC(C)Oc1ccc(C#N)cc1C(=O)N1Cc2cn(-c3cncc(F)c3)nc2C1 CHEMBL4214486 IC50 113.0 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3ccc(OC(F)(F)F)cc3)CCCCC2)CC1 CHEMBL2324163 IC50 118.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cc(C(F)(F)F)on2)C[C@@H]1c1ccc(F)cc1 CHEMBL4107111 IC50 118.0 nM
Cn1cnc(S(=O)(=O)N2CC(Nc3ccnc(C(F)(F)F)c3)C(c3ccc(F)cc3)C2)c1 CHEMBL4160146 Ki 118.0 nM
CC(=O)c1ccc(N2CCN(C(=O)c3cc(S(N)(=O)=O)ccc3N3CCOCC3)CC2)c(F)c1 CHEMBL496110 EC50 120.0 nM
CCCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(c2ccccn2)CC1 CHEMBL463024 IC50 120.0 nM
Cn1cnnc1S(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC2CC2)CC1 CHEMBL482754 IC50 123.6 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2nnc(C(F)(F)F)s2)CC1c1ccc(C(F)(F)F)s1 CHEMBL3954320 IC50 124.0 nM
Oc1ccc2c(c1)C(C1(c3ccc(Cl)cc3)CCC1)NCC2 CHEMBL4167229 Ki 124.0 nM
O=C(NCC1(c2ncccc2F)CCN(S(=O)(=O)c2cccs2)CC1)c1ccc(Cl)cc1Cl CHEMBL482964 IC50 124.6 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2nc(C(F)(F)F)co2)CC1c1ccc(F)cc1 CHEMBL3925294 IC50 125.0 nM
CN(CC[C@@H](Oc1ccc(C(F)(F)F)cc1)c1ccccc1)CC(=O)[O-] CHEMBL61861 Log IC50 125.89 nM
O=C(CN(CC1CCC1)C(=O)c1ccc(-c2ccccn2)cc1)Nc1cc(F)cc(F)c1 CHEMBL1834684 pIC50 125.89 nM
CN(CC[C@@H](Oc1ccc(C(F)(F)F)cc1)c1ccccc1)CC(=O)O CHEMBL360052 pIC50 125.89 nM
COc1cccc(C2(O)CCCCC2N2CCC3(CC2)C(=O)NCC3c2ccc(F)cc2)c1 CHEMBL377569 EC50 127.0 nM
O=C1NCC(c2ccccc2)C12CCN(C1CCCCC1(O)c1cccc(F)c1)CC2 CHEMBL386444 EC50 127.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2)(c2cc(C)ccn2)CC1 CHEMBL517631 IC50 129.0 nM
O=C1NCN(c2ccccc2)C12CCN([C@@H]1CCCC[C@@]1(O)c1ccccn1)CC2 CHEMBL371550 EC50 130.0 nM
COc1cccc([C@]2(O)CCCC[C@H]2N2CCC3(CC2)C(=O)NCN3c2ccccc2)c1 CHEMBL373198 EC50 130.0 nM
O=C1NCN(c2ccccc2)C12CCN([C@@H]1CCCC[C@@]1(O)c1cccc(Cl)c1)CC2 CHEMBL200882 EC50 130.0 nM
O=C1NCN(c2ccccc2)C12CCN([C@H]1CCCC[C@H]1c1cccc(Cl)c1)CC2 CHEMBL199944 EC50 130.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2OC)(c2ccccc2)CC1 CHEMBL464419 IC50 130.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2c(F)cccc2F)(C(=O)N2CCOCC2)CC1 CHEMBL222517 IC50 131.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)c(Cl)c2)(c2ccccn2)CC1 CHEMBL464623 IC50 131.0 nM
Cn1ncc(S(=O)(=O)N2CC(CNC(=O)c3ccc(Cl)cc3Cl)(CC3CC3)C2)n1 CHEMBL485366 IC50 131.7 nM
Cc1ccc(C2(O)CCCCC2N2CCC3(CC2)C(=O)NCC3c2ccc(F)cc2)cc1 CHEMBL209951 EC50 132.0 nM
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1Cc2cnc(C(F)(F)F)cc2C1)C(F)(F)F CHEMBL1631018 EC50 132.0 nM
CCS(=O)(=O)[C@H]1CC[C@](CNC(=O)c2ccc(Cl)cc2Cl)(CC2CC2)CC1 CHEMBL2146716 IC50 132.4 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ccccn2)CC1c1cccc(F)c1 CHEMBL3985970 IC50 133.0 nM
CC1CC(N2CCN(C3CCc4ccc(OCc5noc(-c6ccc(Cl)cc6)n5)cc43)CC2)CC1C CHEMBL239598 Ki 134.0 nM
COc1cccc(N2CCN(C(=O)C3CCS(=O)(=O)CC3)C(c3cccs3)C2)c1 CHEMBL3905073 IC50 134.0 nM
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1Cc2ccc(Cl)cc2C1)C(F)(F)F CHEMBL1631007 EC50 135.0 nM
CCCCS(=O)(=O)NCCOc1ccc2c(c1)[C@@H](Cc1ccc(Cl)c(Cl)c1)[C@@H](N)CC2 CHEMBL4173117 Ki 136.0 nM
CS(=O)(=O)c1ccc(OCCC(F)(F)F)c(C(=O)N2Cc3ccc(C4CCOCC4)cc3C2)c1 CHEMBL1631195 EC50 137.0 nM
Cc1ccc(C2CNC(=O)C23CCN(C2(c4ccccc4)CCCCC2)CC3)cc1 CHEMBL378285 EC50 139.0 nM
CN(CCOc1ccc(-c2ccccc2)cc1-c1ccsc1)CC(=O)O CHEMBL249126 IC50 139.0 nM
Cc1ccc([C@]2(O)CCCC[C@H]2N2CCC3(CC2)C(=O)NCN3c2ccccc2)cc1 CHEMBL200257 EC50 140.0 nM
COc1cc(C(F)(F)F)cc(C(F)(F)F)c1C(=O)NC1(c2ccccc2)CCCN(C)C1 CHEMBL3259943 IC50 140.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1c1ccc(C2CC2)s1 CHEMBL3895457 IC50 141.0 nM
CS(=O)(=O)NCCOc1ccc2c(c1)[C@@H](Cc1ccc(Cl)c(Cl)c1)[C@@H](N)CC2 CHEMBL4168634 Ki 141.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncccn2)CC1c1ccc(F)c(F)c1 CHEMBL3916602 IC50 142.0 nM
Cn1cc(S(=O)(=O)N2CCN(C3(CNC(=O)c4ccc(Cl)cc4Cl)CCCCC3)CC2)cn1 CHEMBL4590387 IC50 146.0 nM
O=C1NCC(c2ccccc2)C12CCN(C1(c3cccs3)CCCCC1)CC2 CHEMBL380037 EC50 147.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2C)(C2CCCCN2C)CC1 CHEMBL460921 IC50 148.0 nM
COc1ccc(Sc2ccc(Cl)cc2N2CCN(CC(=O)O)[C@H](C)C2)cc1 CHEMBL361022 IC50 150.0 nM
O=C(CNC(=O)c1ccc(Cl)cc1)NC(c1ccccc1)c1ccc(Cl)cc1 CHEMBL475928 EC50 150.0 nM
CN(CC[C@@H](Oc1ccc(-c2ccccc2)cc1)c1ccccc1)CC(=O)[O-] CHEMBL58459 Log IC50 151.36 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2nc(C(F)(F)F)co2)CC1c1ccccc1F CHEMBL3897247 IC50 153.0 nM
COc1ccc(CCC(=O)NCC(=O)N2CC(=O)N(C)c3ccc(Cl)cc3C2c2ccccc2)cc1 CHEMBL476555 IC50 154.0 nM
CCOCCn1c(CN2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)nc2cccnc21 CHEMBL4560925 IC50 155.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C(F)(F)F)cn2)C[C@@H]1c1ccc(F)cc1 CHEMBL4112347 IC50 157.0 nM
COc1ccc(C2(O)CCCCC2N2CCC3(CC2)C(=O)NCC3c2ccc(F)cc2)cc1 CHEMBL211620 EC50 158.0 nM
O=C(CN(C(=O)c1ccc(N2CCCC2)nc1)C1CCCCC1)Nc1cc(F)cc(F)c1 CHEMBL1835889 pIC50 158.49 nM
COc1ccc(Sc2ccccc2N2C[C@@H](C)N(CC(=O)O)C[C@@H]2C)cc1 CHEMBL182162 IC50 160.0 nM
COc1ccc(-c2ccc(OCCN3CCC[C@H]3C(=O)O)c(Sc3cccc(F)c3)c2)cc1 CHEMBL377418 IC50 160.0 nM
CN(CCOc1ccccc1Sc1ccccc1)CC(=O)O CHEMBL209446 IC50 160.0 nM
COc1ccc(-c2ccc(OCCN(C)CC(=O)O)c(-c3cccs3)c2)cc1C CHEMBL400979 IC50 161.0 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3c(F)cccc3F)CCC3(CC3)CC2)CC1 CHEMBL2324487 IC50 162.0 nM
N[C@H]1CCc2ccc(OCCNS(=O)(=O)c3cccs3)cc2[C@H]1Cc1ccc(Cl)c(Cl)c1 CHEMBL4176912 Ki 163.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2nc3cc(Cl)c(Cl)cc3[nH]2)CC1c1ccccc1 CHEMBL3925806 IC50 166.0 nM
Cc1cccc(C)c1C(=O)NC(c1ccccc1)C12CC(CN1)C2 CHEMBL4224791 IC50 168.0 nM
COc1ccc(C2(NC(=O)c3c(OC)cc(C(F)(F)F)cc3SC)CCCN(C)C2)cc1 CHEMBL3259933 EC50 170.0 nM
O=C1NCN(c2ccccc2)C12CCN([C@@H]1CCCC[C@@]1(O)c1ccc(Cl)c(Cl)c1)CC2 CHEMBL200227 EC50 173.0 nM
CN(CCOc1ccc(-c2ccccc2Cl)cc1C(=O)c1cccs1)CC(=O)O CHEMBL249557 IC50 175.0 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3ccc(Cl)cc3)CCCCC2)CC1 CHEMBL2324162 IC50 175.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C(F)(F)F)cn2)C[C@@H]1c1cccc(F)c1 CHEMBL4108110 IC50 175.0 nM
COc1cccc(C(NC(=O)c2cccc(C(F)(F)F)c2Cl)C23CCC(CC2)CN3C)c1 CHEMBL4226650 IC50 177.0 nM
CC(=O)c1ccc(N2CCN(C(=O)c3cc(C#N)ccc3N3CCOCC3)CC2)c(F)c1 CHEMBL497766 EC50 180.0 nM
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1Cc2ccc(N3CCCC3)cc2C1)C(F)(F)F CHEMBL1631012 EC50 180.0 nM
COc1ccc2c(c1)CN(C(=O)c1cc(S(C)(=O)=O)ccc1O[C@@H](C)C(F)(F)F)C2 CHEMBL1631011 EC50 180.0 nM
COc1cc(C(F)(F)F)cc(SC)c1C(=O)N[C@]1(c2ccccc2)CCCN(C)C1 CHEMBL3259927 EC50 180.0 nM
COc1cc(C(F)(F)F)cc(SC)c1C(=O)NC1(c2ccc(F)cn2)CCCN(C)C1 CHEMBL3259939 EC50 180.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C(F)(F)F)cn2)C[C@@H]1c1ccc(F)c(F)c1 CHEMBL4114316 IC50 180.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C(F)(F)F)cn2)CC1c1cccc(C(F)(F)F)c1 CHEMBL3893622 IC50 180.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(C(=O)N(C)C)CC1 CHEMBL426710 IC50 181.0 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3c(N)cccc3Cl)CCCC2)CC1 CHEMBL2324482 IC50 183.0 nM
Cc1ccc(N2CCN(C(=O)C3CCS(=O)(=O)CC3)C(c3ccc(F)cc3)C2)cn1 CHEMBL3951891 IC50 183.0 nM
Cn1nncc1S(=O)(=O)N1CC(CNC(=O)c2ccc(Cl)cc2Cl)(CC2CC2)C1 CHEMBL485534 IC50 184.9 nM
Cn1cnc(S(=O)(=O)N2C[C@@H]3[C@H](C2)[C@@]3(CNC(=O)c2ccccc2C(F)(F)F)c2ccccn2)c1 CHEMBL3114968 IC50 185.0 nM
Cn1cnc(S(=O)(=O)N2CC(NC(=O)c3cccc(C(F)(F)F)c3Cl)C(c3ccccc3)C2)c1 CHEMBL4164756 Ki 198.0 nM
Cn1cnc(S(=O)(=O)N2CC(Nc3ccccc3)C(c3ccccc3)C2)c1 CHEMBL4162199 Ki 199.0 nM
CC(C)(C)C1CCCN1C[C@@H](O)CNS(=O)(=O)c1cccc2ccccc12 CHEMBL239811 Log IC50 199.53 nM
CC(C)C1CCCN1C[C@@H](O)CNS(=O)(=O)c1cccc2ccccc12 CHEMBL398398 Log IC50 199.53 nM
O=C(CN(CC1CC1)C(=O)c1ccc(-c2ccccn2)cc1)Nc1cc(F)cc(F)c1 CHEMBL1834678 pIC50 199.53 nM
O=C(NCC1(c2ccccn2)CCN(S(=O)(=O)C2CC2)CC1)c1ccc(Cl)cc1Cl CHEMBL463025 IC50 200.0 nM
O=C(CNC(=O)c1ccncc1)NC(c1ccccc1)c1ccc(Cl)cc1 CHEMBL452423 EC50 200.0 nM
CC(Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc(C(F)(F)F)cc2Cl)CC1)C(F)(F)F CHEMBL1170070 EC50 200.0 nM
Cc1ccc(N2CCN(C(=O)C3CCS(=O)(=O)CC3)C(c3cccc(F)c3)C2)cn1 CHEMBL3983170 IC50 202.0 nM
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1Cc2ccc(C3CCCCO3)cc2C1)C(F)(F)F CHEMBL1631022 EC50 205.0 nM
C[C@H](Oc1ccc(C#N)cc1C(=O)N1Cc2cn(C3CCCC3)nc2C1)C(F)(F)F CHEMBL4210095 IC50 210.0 nM
CN1CC2CCC1(C(NC(=O)c1cccc(C(F)(F)F)c1Cl)c1cccnc1)CC2 CHEMBL4226117 IC50 211.0 nM
CC(C)S(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(c2ccccn2)CC1 CHEMBL463029 IC50 220.0 nM
COc1c(S(C)(=O)=O)ccc(O[C@@H](C)C(F)(F)F)c1C(=O)N1CC(c2ccccc2)C1 CHEMBL4645731 IC50 220.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2nc(C(F)(F)F)co2)CC1c1ccc(C(F)(F)F)s1 CHEMBL3900743 IC50 221.0 nM
CCCC1CNC(=O)C12CCN(C1(c3cccs3)CCCCC1)CC2 CHEMBL378848 EC50 229.0 nM
CN(CCOc1ccc(-c2ccccc2)cc1-c1ccccc1)CC(=O)O CHEMBL250580 IC50 229.0 nM
N#Cc1ccc(C(=O)NCC(=O)NC(c2ccccc2)c2ccc(Cl)cc2)cc1 CHEMBL475927 EC50 230.0 nM
O=C(NC[C@]1(CC2CC2)[C@@H]2CN(S(=O)(=O)CC3CC3)C[C@@H]21)c1ccc(Cl)cc1Cl CHEMBL3114796 IC50 230.0 nM
CCN1CCCC(NC(=O)c2c(OC)cc(C(F)(F)F)cc2C(F)(F)F)(c2ccccc2)C1 CHEMBL3259909 EC50 230.0 nM
COc1cc(C(F)(F)F)cc(C(F)(F)F)c1C(=O)NC1(c2ccccc2)CCCN(C(C)C)C1 CHEMBL3259910 EC50 230.0 nM
COc1cc(C(F)(F)F)cc(SC)c1C(=O)NC1(c2ccc(C)cc2)CCCN(C)C1 CHEMBL3259932 EC50 230.0 nM
O=C1NCC(c2ccccc2)C12CCN(C1CCCCC1c1ccccc1)CC2 CHEMBL214039 EC50 232.0 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3c(F)cccc3F)CCCOCC2)CC1 CHEMBL2324490 IC50 238.0 nM
O=S(=O)(CC1CC1)NCCOc1ccc2c(c1)[C@@H](Cc1ccccc1)[C@@H](N1CCC1)CO2 CHEMBL4168181 Ki 239.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2nnc(C(F)(F)F)o2)CC1c1ccccc1F CHEMBL3910890 IC50 242.0 nM
O=C1NCC(c2ccc(F)cc2)C12CCN(C1(c3ccc(F)cc3)CCCCCC1)CC2 CHEMBL209750 Activity 245.0 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3ccc(Cl)c(Cl)c3)CCCCC2)CC1 CHEMBL2324476 IC50 245.0 nM
O=C1NC[C@@H](c2ccccc2)C12CCN([C@H]1CCCC[C@H]1c1ccccc1)CC2 CHEMBL378398 EC50 246.0 nM
Cn1cnc(S(=O)(=O)N2C[C@@H]3[C@H](C2)[C@@]3(CNC(=O)c2ccc(Cl)cc2Cl)c2ccccn2)c1 CHEMBL3114967 IC50 247.0 nM
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1Cc2ccc(C(F)(F)F)nc2C1)C(F)(F)F CHEMBL1631019 EC50 250.0 nM
CN(CCOc1ccc(-c2ccccc2)cc1C1CCCCC1)CC(=O)O CHEMBL250582 IC50 251.0 nM
CN(CCC(Oc1ccc(C(F)(F)F)cc1)c1ccc(F)cc1)CC(=O)[O-] CHEMBL302908 Log IC50 251.19 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2nc3c(C(F)(F)F)cccc3[nH]2)CC1c1ccccc1 CHEMBL3924703 IC50 252.0 nM
Cc1ccc(N2CCN(C(=O)C3CCS(=O)(=O)CC3)C(c3ccccc3F)C2)cn1 CHEMBL3899719 IC50 255.0 nM
Cc1cnc(C2CN(c3nnc(C(F)(F)F)s3)CCN2C(=O)C2CCS(=O)(=O)CC2)s1 CHEMBL3957819 IC50 257.0 nM
O=C1NCN(Cc2ccccc2)C12CCN([C@H]1CCCC[C@H]1c1ccccc1)CC2 CHEMBL383827 EC50 258.0 nM
COc1ccc([C@]2(O)CCCC[C@H]2N2CCC3(CC2)C(=O)NCN3c2ccccc2)cc1 CHEMBL371966 EC50 261.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2)(C(=O)N2CCOCC2)CC1 CHEMBL220948 IC50 264.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cccnc2)CC1c1cccs1 CHEMBL3936604 IC50 266.0 nM
O=C1NCC(c2ccc(Cl)c(Cl)c2)C12CCN(C1CCCCC1c1ccc(F)cc1)CC2 CHEMBL213962 EC50 270.0 nM
COc1cc(C(F)(F)F)cc(C(F)(F)F)c1C(=O)NC1(c2ccccc2)CCCN(C2CCCC2)C1 CHEMBL3259911 EC50 270.0 nM
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1Cc2ccc(N3CCOCC3)cc2C1)C(F)(F)F CHEMBL1631003 EC50 275.0 nM
O=C1NCC(c2ccc(F)cc2)C12CCN(C1(c3cccs3)CCCCC1)CC2 CHEMBL386659 EC50 281.0 nM
Cc1ccc(C2(N3CCC4(CC3)C(=O)NCC4c3ccccc3)CCCCC2)cc1 CHEMBL213592 EC50 284.0 nM
CN(CCOc1ccc(-c2ccccc2)cc1CC1CCCCC1)CC(=O)O CHEMBL399983 IC50 289.0 nM
COc1ccc(Sc2ccc(Cl)cc2N2CCN(CC(=O)O)C(C)C2)cc1 CHEMBL181805 IC50 290.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cnccn2)CC1c1ccccc1 CHEMBL3899613 IC50 292.0 nM
COc1cccc(-c2ccc(OCCN3CCC[C@H]3C(=O)O)c(Sc3cccc(F)c3)c2)c1 CHEMBL213048 IC50 300.0 nM
CS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(c2ccccn2)CC1 CHEMBL517435 IC50 300.0 nM
Cc1ccc(C(NC(=O)CNC(=O)c2ccc(F)cc2)c2ccccc2)cc1 CHEMBL479085 EC50 300.0 nM
CN1CCCC(NC(=O)c2ccc(C(F)(F)F)cc2Br)(c2ccccc2)C1 CHEMBL3259924 EC50 300.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cccc3ccccc23)CC1c1cccs1 CHEMBL3893041 IC50 306.0 nM
O=C(c1cc([N+](=O)[O-])ccc1N1CCOCC1)N1CCN(c2ccc(Cl)cc2)CC1 CHEMBL497974 EC50 310.0 nM
Cc1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3OC(C)C(F)(F)F)CC2)cc1 CHEMBL1171843 EC50 310.0 nM
Cn1ncnc1S(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC2CC2)CC1 CHEMBL482546 IC50 314.3 nM
CN(CCC(Oc1ccc(C(F)(F)F)cc1)c1ccccc1)CC(=O)[O-] CHEMBL59821 Log IC50 316.23 nM
CC1CCCCN1C[C@@H](O)CNS(=O)(=O)c1cccc2ccccc12 CHEMBL393654 Log IC50 316.23 nM
O=C(NCC1(N2CCN(S(=O)(=O)C3CCC3)CC2)CCCCC1)c1ccc(Cl)cc1Cl CHEMBL4462786 IC50 319.0 nM
Cc1cc(C(F)(F)F)ccc1C(=O)NC1(c2ccccc2)CCCN(C)C1 CHEMBL3259923 EC50 320.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2cnc(C3CC3)cn2)CC1c1ccc(C2CC2)s1 CHEMBL3946407 IC50 333.0 nM
CS(=O)(=O)N1CCN(C2(CNC(=O)c3c(N)cccc3Cl)CCCCC2)CC1 CHEMBL4581616 IC50 339.0 nM
COc1ccccc1C(NC(=O)c1cccc(C(F)(F)F)c1Cl)C12CCC(CC1)CN2C CHEMBL4225455 IC50 340.0 nM
Cc1ccccc1C1(N2CCC3(CC2)C(=O)NCC3c2ccc(F)cc2)CCCCC1 CHEMBL378665 EC50 350.0 nM
COc1ccccc1-c1cc(-c2ccccc2)ccc1OCCN(C)CC(=O)O CHEMBL249125 IC50 351.0 nM
CC1CN(c2ccccc2Sc2ccc(Cl)cc2)C(C)CN1CC(=O)O CHEMBL181643 IC50 360.0 nM
CCCS(=O)(=O)N1C[C@@H]2[C@H](C1)[C@@]2(CNC(=O)c1ccc(Cl)cc1Cl)CC1CC1 CHEMBL3114794 IC50 360.0 nM
Cn1cnc(S(=O)(=O)N2C[C@H](C(=O)Nc3cccc(OC(F)(F)F)c3)[C@@H](c3ccc(F)cc3)C2)c1 CHEMBL4165757 Ki 360.0 nM
O=C(O)[C@@H]1CCCN1CCOc1ccccc1Sc1cccc(Cl)c1 CHEMBL373809 IC50 380.0 nM
COc1cc(C(F)(F)F)cc(C(F)(F)F)c1C(=O)NC1(c2ccccc2)CCCN(CC2CC2)C1 CHEMBL3259912 EC50 380.0 nM
N#Cc1ccc(-c2cccc(F)c2)c(C(=O)N2Cc3cn(-c4cncc(F)c4)nc3C2)c1 CHEMBL4206650 IC50 383.0 nM
O=C(CNC(=O)c1ccccc1)NC(c1ccccc1)c1ccc(Cl)cc1 CHEMBL476763 EC50 390.0 nM
CS(=O)(=O)c1ccc(OCC2CCCCC2)c(C(=O)N2CCN(c3ccc(C#N)cc3F)CC2)c1 CHEMBL1172964 EC50 390.0 nM
O=C1NCC(c2ccc(F)cc2)C12CCN(C1(c3cccc(F)c3)CCCCC1)CC2 CHEMBL436752 EC50 393.0 nM
CC(C)N1CCN(C2CCc3ccc(OCc4noc(-c5ccc(Cl)cc5)n4)cc32)CC1 CHEMBL239596 Ki 394.0 nM
CN(CCC(Oc1ccc(Cl)c(C(F)(F)F)c1)c1ccccc1)CC(=O)[O-] CHEMBL64750 Log IC50 398.11 nM
CCC(C)N(CC(=O)Nc1cc(F)cc(F)c1)C(=O)c1ccc(-c2ccccn2)cc1 CHEMBL1834683 pIC50 398.11 nM
COc1ccc(C(=O)N(Cc2cc(-c3ccccc3)on2)C2CCCCC2)cc1 CHEMBL1835898 pIC50 398.11 nM
CCCN1CNC(=O)C12CCN([C@@H]1CCCC[C@@]1(O)c1ccccc1)CC2 CHEMBL200141 EC50 400.0 nM
O=C(O)[C@@H]1CCCN1CCOc1ccc(Cl)cc1Sc1cccc(F)c1 CHEMBL377605 IC50 400.0 nM
O=C(c1cc([N+](=O)[O-])ccc1N1CCOCC1)N1CCN(c2cccc(C(F)(F)F)c2)CC1 CHEMBL524135 EC50 400.0 nM
CC(C)S(=O)(=O)c1ccc(O[C@@H](C)C(F)(F)F)c(C(=O)N2Cc3cn(-c4ccccc4)nc3C2)c1 CHEMBL4211293 IC50 406.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(c2cccc(N3CCOCC3)n2)CC1 CHEMBL463621 IC50 412.0 nM
Cc1ccc(C2(N3CCC4(CC3)C(=O)NCC4c3ccc(F)cc3)CCCCC2)cc1 CHEMBL439499 EC50 419.0 nM
O=C1NCC(c2ccccc2)C12CCN(C1(c3cccc(F)c3)CCCCC1)CC2 CHEMBL380244 EC50 423.0 nM
COc1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3OC(C)C(F)(F)F)CC2)cc1 CHEMBL1172010 EC50 430.0 nM
O=C1NCC(c2ccc(C(F)(F)F)cc2)C12CCN(C1(c3ccc(F)cc3)CCCCC1)CC2 CHEMBL209947 EC50 433.0 nM
Cn1cnc(S(=O)(=O)N2C[C@H]3CC[C@@H](NC(=O)c4ccc(Cl)cc4Cl)[C@H]3C2)c1 CHEMBL3115231 IC50 433.0 nM
Cc1cc(-n2cc3c(n2)CN(C(=O)c2cc(C#N)ccc2OCC2CC2)C3)ccn1 CHEMBL4218903 IC50 441.0 nM
CN(CC[C@@H](Oc1ccc(C(C)(C)C)cc1)c1ccccc1)CC(=O)[O-] CHEMBL61860 Log IC50 446.68 nM
CCCN1CNC(=O)C12CCN([C@H]1CCCC[C@H]1c1ccccc1)CC2 CHEMBL372402 EC50 450.0 nM
O=C1NCC(c2ccccc2)C12CCN(C1(c3ccc(Cl)cc3)CCCCC1)CC2 CHEMBL211422 EC50 450.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2nnc(C(F)(F)F)s2)C[C@@H]1c1ccc(C(F)(F)F)s1 CHEMBL4111120 IC50 451.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(C(=O)C2CC2)CC1 CHEMBL219929 IC50 472.0 nM
CC1CC2(CCN1C1CCCCC1(O)c1cccc(F)c1)C(=O)NCC2c1ccc(F)cc1 CHEMBL386805 EC50 474.0 nM
COc1cncc(Cl)c1C(=O)N[C@H](c1ccccc1)C12CCC(CC1)CN2C CHEMBL4229281 IC50 474.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccccc2Cl)(c2cccc(N3CCOCC3)n2)CC1 CHEMBL463620 IC50 482.0 nM
Cc1ccnc(C)c1C(=O)N[C@H](c1ccccc1)C12CCC(CC1)CN2C CHEMBL4225468 IC50 494.0 nM
CN(CCOc1ccc(-c2ccccc2)cc1-c1cccc2ccccc12)CC(=O)O CHEMBL250356 IC50 496.0 nM
CN1CCN(c2cccc3ccc(OCc4noc(-c5ccc(Cl)cc5)n4)cc23)CC1 CHEMBL392586 Ki 500.0 nM
CC(=O)c1ccc(N2CCN(C(=O)c3cc([N+](=O)[O-])ccc3N(C)C)CC2)c(F)c1 CHEMBL496121 EC50 500.0 nM
CS(=O)(=O)c1ccc(OC2CCOCC2)c(C(=O)N2CCN(c3ccc(C#N)cc3F)CC2)c1 CHEMBL1173029 EC50 500.0 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3c(N)cccc3Cl)CCN(C)CC2)CC1 CHEMBL2324489 IC50 500.0 nM
CN(CCC(Oc1ccc(Cl)c(Cl)c1)c1ccccc1)CC(=O)[O-] CHEMBL60445 Log IC50 501.19 nM
COc1ccc(C(CCN(C)CC(=O)[O-])Oc2ccc(C(F)(F)F)cc2)cc1 CHEMBL60441 Log IC50 501.19 nM
O=S(=O)(NC[C@H](O)CN1CCCC1C1CC1)c1cccc2ccccc12 CHEMBL239812 Log IC50 501.19 nM
COc1ccc(C(=O)N(CC(=O)Nc2cc(F)cc(F)c2)C2CCCCC2)cc1 CHEMBL1835879 pIC50 501.19 nM
O=C(NCC1(CC2CC2)CCN(S(=O)(=O)c2cn(CC(F)(F)F)nn2)CC1)c1ccc(Cl)cc1Cl CHEMBL520956 IC50 501.6 nM
Cc1ccccc1[C@@H]1CCCC[C@@H]1N1CCC2(CC1)C(=O)NCN2c1ccccc1 CHEMBL372141 EC50 510.0 nM
Cc1ccccc1C(NC(=O)c1cccc(C(F)(F)F)c1Cl)C12CCC(CC1)CN2C CHEMBL4226079 IC50 514.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(C(=O)NCC)CC1 CHEMBL221157 IC50 517.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2cccc(Cl)c2)(c2ccccn2)CC1 CHEMBL464622 IC50 517.0 nM
O=C(O)[C@@H]1CCCN1CCOc1ccc(-c2ccsc2)cc1Sc1cccc(F)c1 CHEMBL210207 IC50 520.0 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3cccc(OC(F)(F)F)c3)CCCCC2)CC1 CHEMBL2324164 IC50 523.0 nM
O=C1NCC(c2ccccc2)C12CCN(C1(c3ccccc3)CCOCC1)CC2 CHEMBL211633 EC50 525.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2nc3c(Cl)cc(Cl)cc3[nH]2)CC1c1ccccc1 CHEMBL3934695 IC50 527.0 nM
COc1cccc(N2CCN(C(=O)c3cc([N+](=O)[O-])ccc3N3CCOCC3)CC2)c1 CHEMBL484680 EC50 530.0 nM
CC(Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2cnc(C(F)(F)F)nc2)CC1)C(F)(F)F CHEMBL1171472 EC50 530.0 nM
CN1CCCC(NC(=O)c2ccc(C(F)(F)F)cc2C(F)(F)F)(c2ccccc2)C1 CHEMBL3259919 EC50 540.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(C(=O)N2CCC(N(C)C)C2)CC1 CHEMBL221209 IC50 544.0 nM
Fc1ccc(C(CCCN2CCC(Cc3nc4cccnc4n3Cc3cccs3)CC2)c2ccc(F)cc2)cc1 CHEMBL4521378 IC50 549.0 nM
Cc1ccc(Sc2ccccc2N2CC(C)N(CC(=O)O)CC2C)cc1 CHEMBL182521 IC50 550.0 nM
Cc1cc2[nH]c(N3CCN(C(=O)C4CCS(=O)(=O)CC4)C(c4ccccc4)C3)nc2cc1Cl CHEMBL3948997 IC50 556.0 nM
Cc1cccc(C2(N3CCC4(CC3)C(=O)NCC4c3ccc(F)cc3)CCCCC2)c1 CHEMBL209380 EC50 563.0 nM
CCCS(=O)(=O)N1CCC(c2ccccn2)([C@@H](C)NC(=O)c2cc(F)cc(F)c2Cl)CC1 CHEMBL461389 IC50 576.0 nM
COc1ccc(Sc2ccccc2N2CC(C)N(CC(=O)O)CC2C)cc1 CHEMBL182666 IC50 580.0 nM
CCOc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc(C#N)cc2F)CC1 CHEMBL1173566 EC50 590.0 nM
CCc1nnc(-c2ccc(-c3ccccc3)nc2)n1-c1cccc(C#N)c1C CHEMBL2419440 IC50 590.0 nM
O=C(O)[C@@H]1CCCN1CCOc1cc(Cl)ccc1Sc1cccc(F)c1 CHEMBL211894 IC50 600.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2nc3ccc(C(F)(F)F)cc3[nH]2)CC1c1ccccc1 CHEMBL3903200 IC50 607.0 nM
COc1ccc([C@@H]2CCCC[C@@H]2N2CCC3(CC2)C(=O)NCN3c2ccccc2)cc1 CHEMBL380611 EC50 610.0 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3c(F)cccc3F)C[C@H]3C[C@H]3C2)CC1 CHEMBL2324486 IC50 621.0 nM
O=C(NC[C@]1(CC2CC2)CC[C@H](S(=O)(=O)CC2CCC2)CC1)c1ccc(Cl)cc1Cl CHEMBL2146720 IC50 629.0 nM
O=C1NCN(C2CCCC2)C12CCN([C@H]1CCCC[C@H]1c1ccccc1)CC2 CHEMBL199571 EC50 630.0 nM
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CC(c2ccc(C(F)(F)F)cc2)C1)C(F)(F)F CHEMBL4639102 IC50 630.0 nM
CC(C)C1CCCCN1C[C@@H](O)CNS(=O)(=O)c1cccc2ccccc12 CHEMBL241289 Log IC50 630.96 nM
O=C(CN(C(=O)c1ccc(-n2ccnc2)cc1)C1CCCCC1)Nc1cc(F)cc(F)c1 CHEMBL1835888 pIC50 630.96 nM
O=C(CN(C(=O)c1ccc(Cl)cc1)C1CCCCC1)Nc1cc(F)cc(F)c1 CHEMBL1835674 pIC50 630.96 nM
Cc1ccccc1-c1ccc(OCCN(C)CC(=O)O)c(C(=O)c2cccs2)c1 CHEMBL249761 IC50 632.0 nM
COc1cc(C(F)(F)F)cc(C(F)(F)F)c1C(=O)NC1(c2ccccc2)CCCNC1 CHEMBL3259908 EC50 660.0 nM
N[C@H]1CCc2ccc(OCCNS(=O)(=O)c3ccccc3)cc2[C@H]1Cc1ccc(Cl)c(Cl)c1 CHEMBL4171585 Ki 660.0 nM
CCCS(=O)(=O)N1CCC(c2ccccn2)([C@@H](C)NC(=O)c2ccc(Cl)cc2Cl)CC1 CHEMBL461388 IC50 661.0 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3c(N)cccc3Cl)Cc3ccccc3C2)CC1 CHEMBL2324484 IC50 661.0 nM
CN1CCCC(NC(=O)c2ccc(Cl)cc2Cl)(c2ccccc2)C1 CHEMBL3259929 EC50 670.0 nM
CN(CCOc1ccc(-c2ccccc2)cc1-c1cccc(Cl)c1)CC(=O)O CHEMBL250784 IC50 674.0 nM
O=C(C1CCS(=O)(=O)CC1)N1CCN(c2ncc(C(F)(F)F)cn2)C[C@@H]1c1ccccc1F CHEMBL4112312 IC50 680.0 nM
O=C1NCC(c2ccccc2)C12CCN(C1(c3ccsc3)CCCCC1)CC2 CHEMBL384498 EC50 682.0 nM
O=C(c1cc([N+](=O)[O-])ccc1N1CCOCC1)N1CCN(c2cccc(Cl)c2)CC1 CHEMBL520339 EC50 700.0 nM
CN(CCOc1ccc(C(F)(F)F)cc1C(=O)c1cccs1)CC(=O)O CHEMBL401195 IC50 702.0 nM
O=C(CNC(=O)c1ccc(F)cc1)NC(c1ccccc1)c1ccncc1 CHEMBL478230 EC50 730.0 nM
O=C1NCN(C2CCCCC2)C12CCN([C@H]1CCCC[C@H]1c1ccccc1)CC2 CHEMBL426109 EC50 750.0 nM
Cn1cnc(S(=O)(=O)N2CC(Nc3cccc(C(F)(F)F)c3)C(c3cccnc3)C2)c1 CHEMBL4174212 Ki 766.0 nM
C[C@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1Cc2cccc(C#N)c2C1)C(F)(F)F CHEMBL1631016 EC50 770.0 nM
CCCS(=O)(=O)N1CCN(C2(CNC(=O)c3ccccc3)CCCCC2)CC1 CHEMBL2324159 IC50 782.0 nM
CC(C)C1(N2CCC3(CC2)C(=O)NCC3c2ccc(F)cc2)CCCCC1 CHEMBL211525 EC50 787.0 nM
CC1CCC(C)N1C[C@@H](O)CNS(=O)(=O)c1cccc2ccccc12 CHEMBL396146 Log IC50 794.33 nM
CS(=O)(=O)c1ccc(OCc2ccccc2)c(C(=O)N2Cc3cc(C(F)(F)F)cnc3C2)c1 CHEMBL1631196 EC50 805.0 nM
CN1CC2CCC1([C@H](NC(=O)c1c(Cl)ccnc1Cl)c1ccccc1)CC2 CHEMBL4224772 IC50 809.0 nM
CCCS(=O)(=O)N1CCC(CNC(=O)c2cccc(C)c2)(c2ccccn2)CC1 CHEMBL464830 IC50 833.0 nM
COc1ccc(-c2ccc(OCCN(C)CC(=O)O)c(C(=O)c3cccs3)c2)cc1OC CHEMBL250170 IC50 834.0 nM
O=C(NCC1(CC2CC2)CN(S(=O)(=O)c2c[nH]nn2)C1)c1ccc(Cl)cc1Cl CHEMBL519701 IC50 870.8 nM
O=C(NC[C@]1(CC2CC2)[C@@H]2CN(S(=O)(=O)c3cccnc3)C[C@@H]21)c1ccc(Cl)cc1Cl CHEMBL3114964 IC50 890.0 nM
CC(Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ccc(C(F)(F)F)nn2)CC1)C(F)(F)F CHEMBL1171648 EC50 900.0 nM
Cn1cnc(S(=O)(=O)N2CC([C@@H](NC(=O)c3ccc(Cl)cc3Cl)c3ccccn3)C2)c1 CHEMBL3115207 IC50 900.0 nM
CN1CC2CCC1(C(NC(=O)c1cccc(C(F)(F)F)c1Cl)c1ccccn1)CC2 CHEMBL4225527 IC50 904.0 nM
Cc1cccc(C)c1C(=O)NC(c1cccc(-c2cnn(C)c2)c1)C12CCC(CC1)CN2C CHEMBL4224997 IC50 946.0 nM
O=C(O)[C@@H]1CCCN1CCOc1cc(-c2ccccc2)ccc1Sc1cccc(F)c1 CHEMBL213982 IC50 950.0 nM
CC(C)CS(=O)(=O)N1CCN(C2(CNC(=O)c3c(N)cccc3Cl)CCCCC2)CC1 CHEMBL4548066 IC50 952.0 nM
CN(CCOc1ccc(-c2ccccc2)cc1-c1nccs1)CC(=O)O CHEMBL250152 IC50 957.0 nM
CN(CCOc1ccc(-c2ccccc2)cc1-c1ccc(Cl)cc1)CC(=O)O CHEMBL399144 IC50 965.0 nM
CC(C)C1(N2CCC3(CC2)C(=O)NCC3c2ccccc2)CCCCC1 CHEMBL377109 EC50 970.0 nM
CN(CC[C@H](Oc1ccc(-c2ccccc2)cc1)c1ccccc1)CC(=O)[O-] CHEMBL62571 Log IC50 977.24 nM
CC(C)=CC1(N2CCC3(CC2)C(=O)NCC3c2ccccc2)CCCCC1 CHEMBL377350 EC50 979.0 nM