NC(N)=NC(=O)c1oc(-c2cc(Cl)ccc2Cl)cc1N1CCCC1 CHEMBL392093 IC50 0.48 nM
Cc1ccc(F)cc1[C@@H]1C/C(=N\N=C(N)N)c2ccccc2C1 CHEMBL3980085 IC50 1.0 nM
Cc1ccc(F)cc1[C@@H]1C/C(=N\N=C(N)N)c2c(C)cccc2C1 CHEMBL3900790 IC50 1.0 nM
C/C(=C\c1cccc(/C=C(\C)C(=O)NC(=N)N)c1)C(=O)N=C(N)N CHEMBL3900457 IC50 2.0 nM
CC1(C)[C@H](C(=O)N=C(N)N)[C@H]1c1ccc(F)c(Br)c1 CHEMBL419578 IC50 3.0 nM
Cc1cc(-c2cnc(CC#N)nc2N2CCC(c3[nH]cnc3C)CC2)ccc1F CHEMBL384143 IC50 4.6 nM
CC1(C)[C@H](C(=O)N=C(N)N)[C@H]1c1cc(Cl)ccc1Cl CHEMBL113443 IC50 5.0 nM
CCc1cc([C@@H]2[C@@H](C(=O)N=C(N)N)C2(C)C)ccc1F CHEMBL112903 IC50 5.0 nM
CC(=O)N1CCC(c2cc(C)c(C(=O)NC(=N)N)cc2C(F)(F)F)CC1 CHEMBL2170611 IC50 5.0 nM
Cc1cc(-n2cccc2)c(S(C)(=O)=O)cc1C(=O)N=C(N)N CHEMBL64360 IC50 5.0 nM
Cc1[nH]c(N)nc1C1CCN(c2ncncc2-c2ccc(F)c(Cl)c2)CC1 CHEMBL211924 IC50 5.4 nM
CC1(C)[C@H](C(=O)N=C(N)N)[C@H]1c1cc(Cl)cc(Cl)c1 CHEMBL51363 IC50 6.0 nM
CC(=O)N1CCC(c2ccc(C(=O)NC(=N)N)cc2C(F)(F)F)CC1 CHEMBL2170610 IC50 6.0 nM
COc1ncc(-c2ccc(F)c(C)c2)c(N2CCC(c3[nH]cnc3C)CC2)n1 CHEMBL217698 IC50 6.5 nM
Cc1cc(-c2cnc(OC(C)C)nc2N2CCC(c3[nH]cnc3C)CC2)ccc1F CHEMBL213568 IC50 7.4 nM
Cc1[nH]c(N)nc1[C@@H]1[C@@H](c2cc(Cl)cc(Cl)c2)C1(C)C CHEMBL51950 IC50 8.0 nM
NC(N)=NC(=O)c1oc(-c2cc(Cl)ccc2Cl)cc1N CHEMBL394633 IC50 8.0 nM
CC1(C)[C@H](C(=O)N=C(N)N)[C@H]1c1cccc2c1CCO2 CHEMBL51879 IC50 9.0 nM
CN(C)c1cc(-c2cc(Cl)ccc2Cl)oc1C(=O)N=C(N)N CHEMBL395897 IC50 9.0 nM
COc1ccc(Cl)cc1-c1cc(C)c(C(=O)N=C(N)N)o1 CHEMBL232748 IC50 10.0 nM
COCC(=O)N1CCC(c2ccc(C(=O)NC(=N)N)cc2C(F)(F)F)CC1 CHEMBL2170608 IC50 10.0 nM
CCC(=O)N1CCC(c2ccc(C(=O)NC(=N)N)cc2C(F)(F)F)CC1 CHEMBL2170609 IC50 11.0 nM
COc1cccc([C@@H]2[C@@H](C(=O)N=C(N)N)C2(C)C)c1 CHEMBL321198 IC50 12.0 nM
COc1ccc(Cl)cc1-c1cc(N(C)C)c(C(=O)N=C(N)N)o1 CHEMBL395898 IC50 12.0 nM
CC1(C)[C@H](C(=O)N=C(N)N)[C@H]1c1cccc(Cl)c1 CHEMBL297962 IC50 14.0 nM
Cn1ccnc1C(=O)N1CCC(c2ccc(C(=O)NC(=N)N)cc2C(F)(F)F)CC1 CHEMBL2170617 IC50 14.0 nM
N=C(N)NC(=O)c1ccc(C2CCN(C(=O)c3ccc(S(N)(=O)=O)cc3)CC2)c(C(F)(F)F)c1 CHEMBL2170615 IC50 14.0 nM
COc1ncc(-c2ccc(F)c(Cl)c2)c(N2CCC(c3[nH]cnc3C)CC2)n1 CHEMBL385944 IC50 15.0 nM
COc1ccc(Cl)cc1-c1cc(N)c(C(=O)N=C(N)N)o1 CHEMBL232940 IC50 15.0 nM
CC(=O)N1CCC(c2cc(C)c(C(=O)NC(=N)N)cc2S(C)(=O)=O)CC1 CHEMBL2170603 IC50 15.0 nM
CCC(=O)N1CCC(c2cc(C)c(C(=O)NC(=N)N)cc2S(C)(=O)=O)CC1 CHEMBL2169894 IC50 15.0 nM
CS(=O)(=O)c1ccc(C(=O)N2CCC(c3ccc(C(=O)NC(=N)N)cc3C(F)(F)F)CC2)cc1 CHEMBL2170632 IC50 15.0 nM
Cc1cc(-c2cc(Cl)ccc2Cl)oc1C(=O)N=C(N)N CHEMBL397141 IC50 16.0 nM
N=C(N)NC(=O)c1ccc(C2CCN(C(=O)C3CC3)CC2)c(C(F)(F)F)c1 CHEMBL2170607 IC50 16.0 nM
CC(C)c1cc([C@@H]2[C@@H](C(=O)N=C(N)N)C2(C)C)ccc1F CHEMBL110637 IC50 17.0 nM
Cn1cncc1C(=O)N1CCC(c2ccc(C(=O)NC(=N)N)cc2C(F)(F)F)CC1 CHEMBL2170618 IC50 18.0 nM
N=C(N)NC(=O)c1ccc(C2CCN(C(=O)c3ccccn3)CC2)c(C(F)(F)F)c1 CHEMBL2170637 IC50 18.0 nM
N=C(N)NC(=O)c1ccc(C2CCN(C(=O)c3cccnc3)CC2)c(C(F)(F)F)c1 CHEMBL2170636 IC50 18.0 nM
N=C(N)NC(=O)c1ccc(C2CCN(C(=O)c3ccncc3)CC2)c(C(F)(F)F)c1 CHEMBL2170635 IC50 18.0 nM
COc1cc(C2CCN(C(C)=O)CC2)c(C(F)(F)F)cc1C(=O)NC(=N)N CHEMBL2170612 IC50 19.0 nM
N=C(N)NC(=O)c1ccc(C2CCN(C(=O)c3ccc(O)nc3)CC2)c(C(F)(F)F)c1 CHEMBL2170639 IC50 19.0 nM
Cc1cc(-c2cncnc2N2CCC(c3[nH]cnc3C)CC2)ccc1F CHEMBL376979 IC50 21.0 nM
N=C(N)NC(=O)c1ccc(C2CCN(C(=O)c3ccc(O)cc3)CC2)c(C(F)(F)F)c1 CHEMBL2170628 IC50 21.0 nM
CC(=O)N1CCC(c2ccc(C(=O)NC(=N)N)cc2S(C)(=O)=O)CC1 CHEMBL2170614 IC50 22.0 nM
Cc1cc(-c2cccc(Cl)c2)oc1C(=O)N=C(N)N CHEMBL396615 IC50 24.0 nM
Cc1cc(-c2ccccc2)oc1C(=O)N=C(N)N CHEMBL232974 IC50 24.0 nM
N#Cc1ccc(C(=O)N2CCC(c3ccc(C(=O)NC(=N)N)cc3C(F)(F)F)CC2)cc1 CHEMBL2170629 IC50 24.0 nM
N=C(N)NC(=O)c1ccc(C2CCN(C(=O)c3ccc(C(N)=O)cc3)CC2)c(C(F)(F)F)c1 CHEMBL2170638 IC50 26.0 nM
Cc1cccc(-c2cncnc2N2CCC(c3[nH]cnc3C)CC2)c1 CHEMBL212033 IC50 27.0 nM
Cc1cc(C(=O)N2CCC(c3ccc(C(=O)NC(=N)N)cc3C(F)(F)F)CC2)nn1C CHEMBL2170616 IC50 27.0 nM
CC(C)C(=O)N1CCC(c2ccc(C(=O)NC(=N)N)cc2C(F)(F)F)CC1 CHEMBL2170606 IC50 28.0 nM
N=C(N)NC(=O)c1ccc(N2CCN(C(=O)c3ccc[nH]3)CC2)c(C(F)(F)F)c1 CHEMBL2105423 IC50 28.0 nM
CCC(=O)N1CCC(c2ccc(C(=O)NC(=N)N)cc2S(C)(=O)=O)CC1 CHEMBL2170613 IC50 29.0 nM
CCCC(=O)N1CCC(c2ccc(C(=O)NC(=N)N)cc2C(F)(F)F)CC1 CHEMBL2170604 IC50 29.0 nM
CNS(=O)(=O)c1ccc(C(=O)N2CCC(c3ccc(C(=O)NC(=N)N)cc3C(F)(F)F)CC2)cc1 CHEMBL2170622 IC50 30.0 nM
CC(C)c1ccc(C(=O)N=C(N)N)cc1S(C)(=O)=O CHEMBL436559 IC50 30.0 nM
Cc1cc([C@@H]2[C@@H](C(=O)N=C(N)N)C2(C)C)ccc1F CHEMBL109362 IC50 32.0 nM
N=C(N)NC(=O)c1ccc(C2CCN(C(=O)c3cccc(-c4cnco4)c3)CC2)c(C(F)(F)F)c1 CHEMBL2170626 IC50 33.0 nM
N#Cc1cccc(C(=O)N2CCC(c3ccc(C(=O)NC(=N)N)cc3C(F)(F)F)CC2)c1 CHEMBL2170630 IC50 35.0 nM
CN(C)S(=O)(=O)c1ccc(C(=O)N2CCC(c3ccc(C(=O)NC(=N)N)cc3C(F)(F)F)CC2)cc1 CHEMBL2170623 IC50 36.0 nM
N=C(N)NC(=O)c1ccc(N2CCC(NC(=O)c3ccc[nH]3)C2)c(C(F)(F)F)c1 CHEMBL2170650 IC50 36.0 nM
Cc1[nH]c(N)nc1[C@@H]1[C@@H](c2cccc(Cl)c2)C1(C)C CHEMBL52381 IC50 39.0 nM
N=C(N)NC(=O)[C@H]1C[C@@H]1c1cc(Cl)ccc1Cl CHEMBL110578 IC50 40.0 nM
Cc1[nH]cnc1C1CCN(c2ncncc2-c2ccc(F)c(Cl)c2)CC1 CHEMBL380382 IC50 41.0 nM
N=C(N)NC(=O)c1ccc(N2CCC(NC(=O)c3ccc[nH]3)CC2)c(C(F)(F)F)c1 CHEMBL2170640 IC50 41.0 nM
N=C(N)NC(=O)c1ccc(C2CCN(C(=O)c3ccc[nH]3)CC2)c(C(F)(F)F)c1 CHEMBL2170641 IC50 45.0 nM
CC(C)CC(=O)N1CCC(c2ccc(C(=O)NC(=N)N)cc2C(F)(F)F)CC1 CHEMBL2170625 IC50 47.0 nM
CN(C)C(=O)c1ccc(C(=O)N2CCC(c3ccc(C(=O)NC(=N)N)cc3C(F)(F)F)CC2)cc1 CHEMBL2170621 IC50 50.0 nM
CS(=O)(=O)c1cccc(C(=O)N2CCC(c3ccc(C(=O)NC(=N)N)cc3C(F)(F)F)CC2)c1 CHEMBL2170633 IC50 50.0 nM
CNC(=O)c1ccc(C(=O)N2CCC(c3ccc(C(=O)NC(=N)N)cc3C(F)(F)F)CC2)cc1 CHEMBL2170620 IC50 52.0 nM
CS(=O)(=O)c1ccccc1C(=O)N1CCC(c2ccc(C(=O)NC(=N)N)cc2C(F)(F)F)CC1 CHEMBL2170634 IC50 58.0 nM
N=C(N)NC(=O)c1cnn(-c2cccc3ncccc23)c1C1CC1 CHEMBL355862 IC50 59.0 nM
Cc1[nH]cnc1C1CCN(c2ncncc2-c2ccccc2Cl)CC1 CHEMBL215399 IC50 61.0 nM
Cc1[nH]cnc1C1CCN(c2ncncc2-c2cccc(Cl)c2)CC1 CHEMBL384466 IC50 61.0 nM
N#Cc1ccccc1C(=O)N1CCC(c2ccc(C(=O)NC(=N)N)cc2C(F)(F)F)CC1 CHEMBL2170631 IC50 61.0 nM
N=C(N)NC(=O)c1ccc(C2CCN(C(=O)C3CCCC3)CC2)c(C(F)(F)F)c1 CHEMBL2170624 IC50 64.0 nM
N=C(N)NC(=O)c1ccc(C2CCN(C(=O)c3ccc(-n4ccnc4)cc3)CC2)c(C(F)(F)F)c1 CHEMBL2170627 IC50 65.0 nM
N=C(N)NC(=O)c1ccc(C2CCN(C(=O)c3ccccc3)CC2)c(C(F)(F)F)c1 CHEMBL2170642 IC50 68.0 nM
CC1(C)[C@H](C(=O)N=C(N)N)[C@H]1c1ccccc1 CHEMBL113620 IC50 69.0 nM
Cc1ccc(C)c(-c2cc(N)c(C(=O)N=C(N)N)o2)c1 CHEMBL232744 IC50 72.0 nM
Cc1oc(-c2cc(Cl)ccc2Cl)nc1C(=O)N=C(N)N CHEMBL452446 IC50 72.0 nM
CC(C)(C)C(=O)N1CCC(c2ccc(C(=O)NC(=N)N)cc2C(F)(F)F)CC1 CHEMBL2170605 IC50 72.0 nM
COc1ccc(Cl)cc1-c1ccc(C(=O)N=C(N)N)o1 CHEMBL192227 IC50 81.0 nM
Cc1cc(-c2cnc(CC(=O)NC(C)C)nc2N2CCC(c3[nH]cnc3C)CC2)ccc1F CHEMBL214646 IC50 87.0 nM
N=C(N)NC(=O)[C@H]1C[C@@H]1c1ccc(F)c(Br)c1 CHEMBL112899 IC50 90.0 nM
COc1ccc(Br)cc1-c1ccc(C(=O)N=C(N)N)o1 CHEMBL195277 IC50 93.0 nM
CNc1cc(-c2cc(Cl)ccc2Cl)oc1C(=O)N=C(N)N CHEMBL233778 IC50 96.0 nM
Cc1[nH]c(-c2cc(Cl)ccc2Cl)nc1C(=O)N=C(N)N CHEMBL474946 IC50 100.0 nM
N=C(N)NC(=O)c1ccc(C2CCN(C(=O)c3ccc(-c4cnco4)cc3)CC2)c(C(F)(F)F)c1 CHEMBL2170649 IC50 102.0 nM
N=C(N)NC(=O)c1ccc(C2CCN(C(=O)c3ccccc3Cl)CC2)c(C(F)(F)F)c1 CHEMBL2170647 IC50 108.0 nM
N=C(N)NC(=O)c1ccc(C2CCN(C(=O)c3ccc(F)cc3)CC2)c(C(F)(F)F)c1 CHEMBL2170643 IC50 109.0 nM
N=C(N)NC(=O)[C@H]1C[C@@H]1c1cccc2c1CCO2 CHEMBL114393 IC50 120.0 nM
N=C(N)NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 CHEMBL192825 IC50 120.0 nM
COc1ccc(F)cc1-c1cc(N)c(C(=O)N=C(N)N)o1 CHEMBL232355 IC50 120.0 nM
CN(C)c1cc(-c2cccc(Cl)c2)oc1C(=O)N=C(N)N CHEMBL233154 IC50 120.0 nM
CN(C)c1cc(-c2ccccc2)oc1C(=O)N=C(N)N CHEMBL395667 IC50 120.0 nM
CC(C)Oc1ccc(Cl)cc1-c1ccc(C(=O)N=C(N)N)o1 CHEMBL371801 IC50 130.0 nM
Cc1cc(-c2cc(F)ccc2F)oc1C(=O)N=C(N)N CHEMBL232558 IC50 130.0 nM
COc1ccc(C(=O)N2CCC(c3ccc(C(=O)NC(=N)N)cc3C(F)(F)F)CC2)cc1 CHEMBL2170619 IC50 132.0 nM
N=C(N)NC(=O)c1ccc(-c2cc(Cl)ccc2O)o1 CHEMBL193004 IC50 140.0 nM
CCOc1ccc(Cl)cc1-c1ccc(C(=O)N=C(N)N)o1 CHEMBL363344 IC50 140.0 nM
NC(N)=NC(=O)c1oc(-c2cccc(Cl)c2)cc1N CHEMBL232124 IC50 150.0 nM
COc1ccccc1-c1cc(N)c(C(=O)N=C(N)N)o1 CHEMBL231927 IC50 150.0 nM
N=C(N)NC(=O)c1cnn(-c2cccc3ccccc23)c1C1CC1 CHEMBL354137 IC50 160.0 nM
N=C(N)NC(=O)c1cc2c(I)cccc2s1 CHEMBL196715 IC50 170.0 nM
N=C(N)NC(=O)c1ccc(N2CCCC(NC(=O)c3ccc[nH]3)C2)c(C(F)(F)F)c1 CHEMBL2170651 IC50 172.0 nM
CC1(C)[C@H](c2cc(Cl)cc(Cl)c2)[C@H]1c1c[nH]c(N)n1 CHEMBL49235 IC50 180.0 nM
N=C(N)NC(=O)c1cc2c(Br)cccc2s1 CHEMBL197401 IC50 200.0 nM
N=C(N)NC(=O)c1cc2c(Cl)cccc2s1 CHEMBL195422 IC50 200.0 nM
Cc1ccc(C)c(-c2nc(C(=O)N=C(N)N)c(C)o2)c1 CHEMBL523484 IC50 220.0 nM
Cc1ccc(F)cc1-c1ccc(C(=O)N=C(N)N)o1 CHEMBL189789 IC50 230.0 nM
CCc1cc(-c2cccc(Cl)c2)oc1C(=O)N=C(N)N CHEMBL232975 IC50 230.0 nM
Cc1ccccc1-c1cc(N)c(C(=O)N=C(N)N)o1 CHEMBL398144 IC50 240.0 nM
COc1ccc(Cl)cc1-c1nc(C(=O)N=C(N)N)c(C)[nH]1 CHEMBL491155 IC50 240.0 nM
Cc1ccccc1-c1cncnc1N1CCC(c2[nH]cnc2C)CC1 CHEMBL215510 IC50 250.0 nM
CCc1cccc2sc(C(=O)N=C(N)N)cc12 CHEMBL196790 IC50 270.0 nM
N=C(N)NC(=O)[C@H]1C[C@@H]1c1cccc(Cl)c1 CHEMBL331141 IC50 280.0 nM
N=C(N)NC(=O)c1ccc(C2CCN(C(=O)c3ccc(Cl)cc3)CC2)c(C(F)(F)F)c1 CHEMBL2170645 IC50 306.0 nM
C=Cc1cccc2sc(C(=O)NC(=N)N)cc12 CHEMBL425378 IC50 310.0 nM
N=C(N)NC(=O)c1ccc(C2CCN(C(=O)c3ccc(C(F)(F)F)cc3)CC2)c(C(F)(F)F)c1 CHEMBL2170644 IC50 320.0 nM
Cc1ccccc1-c1ccc(C(=O)N=C(N)N)o1 CHEMBL192634 IC50 340.0 nM
N=C(N)NC(=O)c1cnn(-c2ccccc2)c1C1CC1 CHEMBL355071 IC50 350.0 nM
COc1cccc(-c2cncnc2N2CCC(c3[nH]cnc3C)CC2)c1 CHEMBL450633 IC50 350.0 nM
Cc1[nH]cnc1C1CCN(c2ncncc2-c2ccc(Cl)cc2)CC1 CHEMBL425073 IC50 350.0 nM
N=C(N)NC(=O)c1ccc(C2CCN(C(=O)c3cccc(Cl)c3)CC2)c(C(F)(F)F)c1 CHEMBL2170646 IC50 385.0 nM
N=C(N)NC(=O)c1cc2c(C(F)(F)F)cccc2s1 CHEMBL197519 IC50 400.0 nM
NC(N)=NC(=O)c1oc(-c2cc(F)ccc2F)cc1N CHEMBL391171 IC50 410.0 nM
COc1ccc(F)cc1-c1ccc(C(=O)N=C(N)N)o1 CHEMBL189792 IC50 480.0 nM
Cc1cccc2sc(C(=O)N=C(N)N)cc12 CHEMBL196487 IC50 480.0 nM
NC(N)=NC(=O)c1oc(-c2cc(Cl)ccc2Cl)cc1N1CCCCC1 CHEMBL392311 IC50 480.0 nM
Cc1[nH]c(-c2cccc(Cl)c2Cl)nc1C(=O)N=C(N)N CHEMBL474945 IC50 500.0 nM
Cc1[nH]cnc1C1CCN(c2ncncc2-c2ccccc2)CC1 CHEMBL215509 IC50 520.0 nM
Cc1[nH]c(-c2cc(Cl)cc(Cl)c2)nc1C(=O)N=C(N)N CHEMBL514807 IC50 520.0 nM
COc1cccc([C@H]2C[C@@H]2C(=O)N=C(N)N)c1 CHEMBL114342 IC50 540.0 nM
Cc1[nH]cnc1C1CCN(c2ncnc(Cl)c2-c2ccccc2)CC1 CHEMBL215928 IC50 580.0 nM
Cc1ccc(C)c(-c2ccc(C(=O)N=C(N)N)o2)c1 CHEMBL366228 IC50 650.0 nM
N=C(N)NC(=O)c1cc2c(-c3cc(Cl)cc(Cl)c3)cccc2s1 CHEMBL425565 IC50 680.0 nM
NC(N)=NC(=O)c1oc(-c2cccc(F)c2)cc1N CHEMBL441127 IC50 680.0 nM
N=C(N)NC(=O)c1ccc(-c2cc(Cl)cc(Cl)c2)o1 CHEMBL193311 IC50 730.0 nM
CC1(C)[C@H](c2cccc(Cl)c2)[C@H]1c1c[nH]c(N)n1 CHEMBL51727 IC50 750.0 nM
N=C(N)NC(=O)c1ccc(-c2cccc(Cl)c2)o1 CHEMBL192185 IC50 750.0 nM
Cc1cccc(-c2cc(N)c(C(=O)N=C(N)N)o2)c1 CHEMBL231929 IC50 770.0 nM
CCN(c1nc(N)c(C(=O)NC(=N)N)nc1Cl)C(C)C CHEMBL517986 IC50 800.0 nM
COc1ccc(F)cc1-c1nc(C(=O)N=C(N)N)c(C)[nH]1 CHEMBL490553 IC50 800.0 nM
CCOc1ncnc(N2CCC(c3[nH]cnc3C)CC2)c1-c1ccccc1 CHEMBL211922 IC50 820.0 nM
CNc1cc(-c2cccc(Cl)c2)oc1C(=O)N=C(N)N CHEMBL395900 IC50 820.0 nM
CNc1cc(-c2ccccc2)oc1C(=O)N=C(N)N CHEMBL396616 IC50 820.0 nM
Cc1c(C(=O)N=C(N)N)cnn1-c1ccccc1 CHEMBL352933 IC50 830.0 nM
CC(C)c1cccc2sc(C(=O)N=C(N)N)cc12 CHEMBL193812 IC50 850.0 nM
Cc1c(C(=O)N=C(N)N)cnn1-c1cccc2ncccc12 CHEMBL167495 IC50 860.0 nM
Cc1oc(-c2cc(Cl)cc(Cl)c2)nc1C(=O)N=C(N)N CHEMBL490954 IC50 890.0 nM
COc1ccccc1-c1cncnc1N1CCC(c2[nH]cnc2C)CC1 CHEMBL212856 IC50 940.0 nM
Cc1[nH]cnc1[C@@H]1[C@@H](c2cc(Cl)cc(Cl)c2)C1(C)C CHEMBL301286 IC50 950.0 nM
N=C(N)NC(=O)[C@H]1C[C@@H]1c1ccccc1Cl CHEMBL112146 IC50 980.0 nM
Cc1ccc(-c2cncnc2N2CCC(c3[nH]cnc3C)CC2)cc1 CHEMBL214922 IC50 1000.0 nM