CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 Kd 0.02 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 3.0 nM
COc1ccccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O CHEMBL4875188 Ki 3.7 nM
COc1cc(Br)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O CHEMBL4878325 Ki 3.9 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 Kd 4.7 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 5.0 nM
Cc1cccc(Nc2nc(NC3CCCCC3N)cnc2C(N)=O)c1 CHEMBL1974328 pKi 5.012 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 pKi 5.012 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 6.0 nM
COc1ccccc1C1=C(Nc2cccc3ccccc23)C(=O)NC1=O CHEMBL4877889 Ki 6.0 nM
CCCCNc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL3326006 IC50 6.14 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 6.31 nM
COc1ccccc1C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O CHEMBL156277 Ki 6.6 nM
CNC(=O)C(C)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(C)cc5)cc4)csc23)cn1 CHEMBL1970142 pKi 7.943 nM
CCc1cccc(NC(=O)Nc2ccc3c(c2)CCc2sc4ncnc(N)c4c2-3)c1 CHEMBL1968406 pKi 7.943 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 pKi 7.943 nM
COc1ccccc1C1=C(Nc2ccc(O)c(Cl)c2)C(=O)NC1=O CHEMBL157089 Ki 8.5 nM
COc1ccc(Br)cc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O CHEMBL4856751 Ki 9.7 nM
Clc1cc(-c2c[nH]c3ncccc23)cc(NCc2ccccc2)n1 CHEMBL1969588 pKi 10.0 nM
NC(=O)c1c(OCc2c(F)cc(Br)cc2F)nsc1NC(=O)NCCCCN1CCCC1 CHEMBL253969 pKi 10.0 nM
CCCCOc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1996817 pKi 12.59 nM
COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(C(N)=O)s3)c2cc1OC CHEMBL514499 pKi 12.59 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 13.0 nM
COc1ccccc1C1=C(Nc2cccc(F)c2)C(=O)NC1=O CHEMBL4855513 Ki 13.0 nM
COc1ccccc1C1=C(Nc2ccc3c(c2)OCO3)C(=O)NC1=O CHEMBL4869745 Ki 15.0 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 15.85 nM
COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1 CHEMBL491473 pKi 15.85 nM
CNC(=O)C=Cc1cnc(N)c2c(-c3cc(F)c4[nH]c(C)cc4c3)csc12 CHEMBL2006778 pKi 15.85 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 15.85 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)cc1 CHEMBL1982466 pKi 15.85 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)csc12 CHEMBL2005631 pKi 15.85 nM
COc1ccccc1C1=C(Nc2cccc(SC)c2)C(=O)NC1=O CHEMBL4857159 Ki 17.0 nM
O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1ccc(O)c(Cl)c1 CHEMBL157141 Ki 17.0 nM
COc1ccccc1C1=C(Nc2ccc3ncccc3c2)C(=O)NC1=O CHEMBL4868821 Ki 17.0 nM
COc1cc(NC(=O)C(C)C)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O CHEMBL4867952 Ki 17.0 nM
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL601719 Kd 18.0 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1998585 pKi 19.95 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)c1 CHEMBL1967116 pKi 19.95 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 19.95 nM
Cc1cccc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)c1 CHEMBL1965507 pKi 19.95 nM
COc1ccccc1C1=C(Nc2ccc(SC)cc2)C(=O)NC1=O CHEMBL349540 Ki 21.0 nM
COc1ccc(NC2=C(c3ccccc3OC)C(=O)NC2=O)cc1 CHEMBL4852101 Ki 22.0 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 23.0 nM
COc1ccccc1C1=C(Nc2ccc(-c3ccccc3)cc2)C(=O)NC1=O CHEMBL4851482 Ki 25.0 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(-c4ccccc4)c3n2)c1 CHEMBL1988163 pKi 25.12 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 pKi 25.12 nM
C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1 CHEMBL553 Kd 26.0 nM
O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1cccc(Cl)c1 CHEMBL156506 Ki 28.0 nM
N#Cc1cccc(NC2=C(c3cccc4ccccc34)C(=O)NC2=O)c1 CHEMBL4877101 Ki 29.0 nM
COc1cccc(NC2=C(c3ccccc3OC)C(=O)NC2=O)c1 CHEMBL4847820 Ki 29.0 nM
COc1cc(-c2ccc(Cl)nc2Cl)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O CHEMBL4845800 Ki 30.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL244378 pKi 31.62 nM
CC(Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL1825138 pKi 31.62 nM
Cc1cc(C)cc(NC(=O)Nc2ccc3c(c2)CCc2sc4ncnc(N)c4c2-3)c1 CHEMBL1964687 pKi 31.62 nM
CCN(CC)CCNC(=O)C=Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL2004716 pKi 31.62 nM
NC(=O)c1cccc(-c2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982957 pKi 31.62 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(C)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1984162 pKi 31.62 nM
CC(C)(C(N)=O)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1967720 pKi 31.62 nM
CCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)csc12 CHEMBL1979516 pKi 31.62 nM
CSc1cccc(NC2=C(c3ccccc3Cl)C(=O)NC2=O)c1 CHEMBL4858023 Ki 33.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 35.0 nM
COc1ccccc1C1=C(Nc2ccc(O)cc2)C(=O)NC1=O CHEMBL160338 Ki 35.0 nM
COc1ccccc1C1=C(Nc2ccc(C(=O)c3ccccc3)cc2)C(=O)NC1=O CHEMBL4876254 Ki 37.0 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C(C)C(=O)N(C)C)c5)cnc(N)c34)cc2)cc1 CHEMBL2001485 pKi 39.81 nM
OCCCNc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL2000071 pKi 39.81 nM
Cc1ccc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)cc1 CHEMBL1972576 pKi 39.81 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)O)c5)cnc(N)c34)cc2)c1 CHEMBL1989708 pKi 39.81 nM
COC(C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 CHEMBL1981047 pKi 39.81 nM
COc1cc2c(cc1F)C(c1ccccc1Cl)=Nc1c(n[nH]c1C)N2 CHEMBL1980391 pKi 39.81 nM
O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1ccc(O)cc1 CHEMBL347702 Ki 40.0 nM
COc1ccc(-c2ccccc2)cc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O CHEMBL4869281 Ki 40.0 nM
N#Cc1cccc(NC2=C(c3ccccc3Cl)C(=O)NC2=O)c1 CHEMBL4848202 Ki 41.0 nM
CN1CCN(c2ccc(Nc3cc(-c4cccc(-n5ccc6cc(C7CC7)cc(F)c6c5=O)c4CO)cn(C)c3=O)nc2)CC1 CHEMBL2057918 IC50 43.0 nM
COc1ccccc1C1=C(Nc2ccc(-c3ccsc3)cc2)C(=O)NC1=O CHEMBL4863077 Ki 43.0 nM
O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1cccc(F)c1 CHEMBL4878748 Ki 44.0 nM
CCC[C@H](C)Nc1ncc2c(-c3ccc(CN4CCCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4283353 IC50 47.0 nM
COc1ccccc1C1=C(Nc2ccc(N3CCOCC3)cc2)C(=O)NC1=O CHEMBL4854271 Ki 47.0 nM
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=O)c1c(F)cccc1F CHEMBL191003 Kd 48.0 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)cc1C CHEMBL2000335 pKi 50.12 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 50.12 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 51.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 56.0 nM
O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1cccc(O)c1 CHEMBL160937 Ki 56.0 nM
CC[C@@](C)(Nc1ccnc(-c2c[nH]c3ncccc23)n1)C(=O)NCC(F)(F)F CHEMBL3039513 Kd apparent 58.0 nM
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC)cc1N(C)CCN(C)C CHEMBL4473365 IC50 58.0 nM
CSc1ccc(NC2=C(c3ccccc3Cl)C(=O)NC2=O)cc1 CHEMBL156563 Ki 59.0 nM
COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1 CHEMBL1908396 Kd 60.0 nM
COc1ccccc1C1=C(Nc2cccc(O)c2)C(=O)NC1=O CHEMBL160231 Ki 60.0 nM
COc1ccccc1C1=C(Nc2cccc(C(F)(F)F)c2)C(=O)NC1=O CHEMBL4847807 Ki 61.0 nM
CCCn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1993941 pKi 63.1 nM
Cc1cccc(NC(=O)Nc2ccc3c(c2)CCc2sc4ncnc(N)c4c2-3)c1 CHEMBL1242373 pKi 63.1 nM
N#Cc1ccc2nc(N)n(-c3nc(-c4ccccc4)cs3)c2c1 CHEMBL1996066 pKi 63.1 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL180022 Kd 66.0 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1 CHEMBL3301622 Kd apparent 68.0 nM
O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1ccccc1 CHEMBL347647 Ki 69.0 nM
O=C1NC(=O)C(c2ccccc2C(F)(F)F)=C1Nc1ccc(O)c(Cl)c1 CHEMBL4851803 Ki 76.0 nM
CC(O)Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL2002165 pKi 79.43 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(OC(F)F)cc5)cc4)csc23)cn1 CHEMBL1988387 pKi 79.43 nM
OCC(CO)Nc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1992922 pKi 79.43 nM
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCOCC4)c3)n2)c1 CHEMBL1090360 pKi 79.43 nM
Nc1ncnc2scc(C(=O)Nc3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL1988594 pKi 79.43 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc32)c1C CHEMBL1990885 pKi 79.43 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL572878 Kd 82.0 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 84.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 CHEMBL103667 Kd 86.0 nM
COc1cc(NC2=C(c3ccccc3OC)C(=O)NC2=O)cc(OC)c1 CHEMBL4848740 Ki 86.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL574737 Kd apparent 89.0 nM
COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 CHEMBL24828 Kd 95.0 nM
COc1ccccc1C1=C(Nc2cccc(S(C)(=O)=O)c2)C(=O)NC1=O CHEMBL4877795 Ki 95.0 nM
COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(S(C)(=O)=O)CC2)nc1N CHEMBL384304 Kd 96.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCNS(C)(=O)=O)cnc(N)c34)cc2)c1 CHEMBL1994321 pKi 100.0 nM
COc1ccc(-c2cc3nccn3c(Nc3ccccc3C(N)=O)n2)cc1OC CHEMBL1998112 pKi 100.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)c1 CHEMBL196363 pKi 100.0 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)(C)O)c5)cnc(N)c34)cc2)cc1 CHEMBL2004290 pKi 100.0 nM
CCOC(=O)C1=c2sc(=Cc3ccco3)c(=O)n2C(N)=C(C#N)C1c1ccco1 CHEMBL1999112 pKi 100.0 nM
CSc1cccc(NC2=C(c3ccccc3C(F)(F)F)C(=O)NC2=O)c1 CHEMBL4860051 Ki 100.0 nM
COc1ccccc1C1=C(Nc2cc(Cl)c(O)c(Cl)c2)C(=O)NC1=O CHEMBL345800 Ki 110.0 nM
COc1ccccc1C1=C(Nc2cccc(-c3ccsc3)c2)C(=O)NC1=O CHEMBL4855633 Ki 110.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 113.0 nM
COc1cccc(C2=C(Nc3cccc(Cl)c3)C(=O)NC2=O)c1 CHEMBL346829 Ki 120.0 nM
COc1ccccc1C1=C(Nc2ccc(Nc3ccccc3)cc2)C(=O)NC1=O CHEMBL4873631 Ki 120.0 nM
CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccccc3n2)CC1 CHEMBL565612 pKi 125.89 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 125.89 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN(C)C)cnc(N)c34)cc2)c1 CHEMBL1979883 pKi 125.89 nM
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1973540 pKi 125.89 nM
OC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1991674 pKi 125.89 nM
O=C(Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCCC4=O)c3)n2)c1)c1c(F)cccc1F CHEMBL2006715 pKi 125.89 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)c1 CHEMBL1970203 pKi 125.89 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(c2ncccn2)CC1 CHEMBL1986530 pKi 125.89 nM
Cc1cc2cc(-c3csc4c(-c5cccc(S(C)(=O)=O)c5)cnc(N)c34)ccc2[nH]1 CHEMBL1997822 pKi 125.89 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(O)c2)n1 CHEMBL243088 pKi 125.89 nM
O=C1NC(=O)C(c2ccccc2C(F)(F)F)=C1Nc1cccc(Cl)c1 CHEMBL4848852 Ki 130.0 nM
CC(C)c1cc(CNc2nc(Nc3cc(C4CC4)[nH]n3)cc(N3CCN(C)CC3)n2)on1 CHEMBL3545085 Kd apparent 138.0 nM
Cn1c(NCC(N)Cc2ccccc2)nc(-c2ccncc2)c(-c2ccc3ccccc3c2)c1=O CHEMBL1990496 pKi 158.49 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)cc1)CCN2 CHEMBL411903 pKi 158.49 nM
CN1CCN(c2ccc(C(=O)Nc3n[nH]c4ccc(Cc5cc(F)cc(F)c5)cc34)c(NC3CCOCC3)c2)CC1 CHEMBL1983268 pKi 158.49 nM
N#Cc1ncc2nc1OCCCCOc1cc(NCc3cncs3)c(Cl)cc1NC(=O)N2 CHEMBL248757 pKi 158.49 nM
CCN(CC)CC#Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL2001257 pKi 158.49 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN5CCOCC5)cnc(N)c34)cc2)c1 CHEMBL1982465 pKi 158.49 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 158.49 nM
Brc1cnc2[nH]cc(-c3ccccc3)c2c1 CHEMBL1992634 pKi 158.49 nM
Cc1cc2c(F)c(Oc3ncnn4cc(OC[C@@H](C)O)c(C)c34)ccc2[nH]1 CHEMBL377300 Kd 170.0 nM
COc1ccccc1C1=C(Nc2ccc(OCc3ccccc3)c(Cl)c2)C(=O)NC1=O CHEMBL4859423 Ki 170.0 nM
COc1cc(-c2ccsc2)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O CHEMBL4875006 Ki 180.0 nM
Cc1n[nH]c2cnc(-c3cncc(OCC(N)Cc4cccc(C(F)(F)F)c4)c3)cc12 CHEMBL1998159 pKi 199.53 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN5CCCC5)cnc(N)c34)cc2)c1 CHEMBL1973211 pKi 199.53 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 pKi 199.53 nM
Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)cncc21 CHEMBL1964692 pKi 199.53 nM
Cc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1Nc1ccc(OCC(N)=O)cc1 CHEMBL1988838 pKi 199.53 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CC(C)(C)N)cnc(N)c34)cc2)c1 CHEMBL1979577 pKi 199.53 nM
Cc1ccccc1NC(=O)Nc1ccc(NC(=O)c2csc3ncnc(N)c23)cc1 CHEMBL1980144 pKi 199.53 nM
O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1cccc(C(F)(F)F)c1 CHEMBL4855321 Ki 200.0 nM
COc1ccc(NC2=C(c3ccccc3OC)C(=O)NC2=O)cc1OC CHEMBL4876004 Ki 210.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 220.0 nM
O=C(O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12 CHEMBL1230165 Kd apparent 220.0 nM
Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O CHEMBL477772 Kd 240.0 nM
CCc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ncnc4cc(OC)c(OC)cc34)c(F)c1)c(C)n2C CHEMBL4571241 Kd 240.0 nM
O=C1NC(=O)C(c2ccccc2C(F)(F)F)=C1Nc1cccc(F)c1 CHEMBL4875281 Ki 240.0 nM
COc1cc(-c2cccnc2)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O CHEMBL4852451 Ki 240.0 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL607707 Kd 250.0 nM
Cc1cc(N2CCOCC2)cc2[nH]c(-c3c(NCC(O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL2005886 pKi 251.19 nM
NC(=O)c1sc(-n2cnc3ccccc32)cc1OCc1ccccc1C(F)(F)F CHEMBL481491 pKi 251.19 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(Cc4ccccc4)c3n2)c1 CHEMBL1993424 pKi 251.19 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3nsc4ncnc(N)c34)cc2)c1 CHEMBL262433 pKi 251.19 nM
NC(=O)c1cc2c(-c3ccc(F)cc3)cncc2s1 CHEMBL1974310 pKi 251.19 nM
Cc1cccc(NC(=O)Nc2ccc(-c3coc4ncnc(N)c34)cc2)c1 CHEMBL1983963 pKi 251.19 nM
CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL1084546 pKi 251.19 nM
NC(=O)c1ccc(-c2c[nH]c3nccc(Cl)c23)cc1 CHEMBL1982711 pKi 251.19 nM
CNC(=O)c1ccccc1Sc1ccc2c(C=Cc3ccccn3)n[nH]c2c1 CHEMBL1988437 pKi 251.19 nM
O=C1NC(=O)C(c2ccccc2C(F)(F)F)=C1Nc1ccc(O)cc1 CHEMBL4876241 Ki 280.0 nM
O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1cc(Cl)c(O)c(Cl)c1 CHEMBL157258 Ki 300.0 nM
CS(=O)(=O)c1cccc(NC2=C(c3ccccc3Cl)C(=O)NC2=O)c1 CHEMBL4848515 Ki 310.0 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 316.23 nM
CNC(=O)COc1ccc(Nc2nc(Nc3ccc(C)c(S(N)(=O)=O)c3)ncc2F)cc1 CHEMBL1978099 pKi 316.23 nM
O=C(Nc1cccc(Cl)c1)Nc1ncc(CCNc2ncnc3ccsc23)s1 CHEMBL482767 pKi 316.23 nM
CC(C)(C)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1970104 pKi 316.23 nM
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCCC4=O)c3)n2)c1 CHEMBL1991429 pKi 316.23 nM
Nc1ncnc2sc3c(c12)-c1ccc(NC(=O)Nc2ccccc2)cc1CC3 CHEMBL1994693 pKi 316.23 nM
Nc1ncc(-c2ccoc2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1966514 pKi 316.23 nM
CSc1ccc(NC2=C(c3ccccc3C(F)(F)F)C(=O)NC2=O)cc1 CHEMBL4869099 Ki 320.0 nM
COc1cc(-c2ccccc2)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O CHEMBL4852765 Ki 330.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 CHEMBL450786 Kd 350.0 nM
COc1ccccc1C1=C(Nc2cccc3cccnc23)C(=O)NC1=O CHEMBL4871372 Ki 370.0 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc2cc[nH]c12 CHEMBL3416026 Kd 380.0 nM
COc1ccc(-c2ccc(OCc3ccccc3)c(F)c2)cc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O CHEMBL4875291 Ki 380.0 nM
COc1ccccc1NC1=C(c2ccccc2OC)C(=O)NC1=O CHEMBL4862897 Ki 390.0 nM
Nc1ncnc2onc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)c12 CHEMBL213505 pKi 398.11 nM
NC1CCC(Nc2nccc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1966628 pKi 398.11 nM
CNC(=O)c1cc2c(-c3ccccc3F)n[nH]c2s1 CHEMBL1977681 pKi 398.11 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2C CHEMBL519697 pKi 398.11 nM
CCOc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)cc1 CHEMBL1974254 pKi 398.11 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN)cnc(N)c34)cc2)c1 CHEMBL1965988 pKi 398.11 nM
COc1ccc2c(NC(=O)Nc3cccc(C(F)(F)F)n3)ccnc2c1 CHEMBL1982660 pKi 398.11 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL1967531 pKi 398.11 nM
Nc1ncc(-c2ccoc2)c2scc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)c12 CHEMBL1965570 pKi 398.11 nM
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 CHEMBL939 pKi 398.11 nM
Cc1ccc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1988075 pKi 398.11 nM
COc1cc(C=C(C#N)c2nc3cc(C)ccc3[nH]2)c(Br)cc1O CHEMBL2000345 pKi 398.11 nM
CN(C)C[C@@H]1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1 CHEMBL91829 Kd 400.0 nM
COc1cccc(C2=C(Nc3ccc(SC)cc3)C(=O)NC2=O)c1 CHEMBL158526 Ki 400.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 402.0 nM
C=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1 CHEMBL31965 Kd 440.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL223360 Kd 450.0 nM
O=C1NC(=O)C(c2ccccc2C(F)(F)F)=C1Nc1cccc(O)c1 CHEMBL4855533 Ki 450.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 460.0 nM
COc1ccccc1C1=C(Nc2ccccc2SC)C(=O)NC1=O CHEMBL4878043 Ki 490.0 nM
COc1ccc(NC2=C(c3ccccc3OC)C(=O)NC2=O)c(OC)c1 CHEMBL4870064 Ki 500.0 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 501.19 nM
CCn1c(C)c(-c2ccnc(Nc3cccc(OC)c3)n2)sc1=O CHEMBL1986263 pKi 501.19 nM
O=C1NCCc2[nH]c(-c3ccnc(C=Cc4ccccc4)c3)cc21 CHEMBL1997129 pKi 501.19 nM
Cc1c[nH]c2nccc(Oc3c(F)cc(Nc4cc(Cl)nc(N)n4)cc3F)c12 CHEMBL1971943 pKi 501.19 nM
Cc1ccc(NC(=O)Nc2ccc(-c3coc4ncnc(N)c34)cc2)cc1 CHEMBL2005828 pKi 501.19 nM
NC(=O)c1cc2c(Oc3ccc(Br)cc3)cncc2s1 CHEMBL116070 pKi 501.19 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 pKi 501.19 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(-c3c(C)sc4ncnc(N)c34)cc2)c1 CHEMBL371206 pKi 501.19 nM
COc1cc(Nc2nccc(Nc3cc(C4CCCCC4)no3)n2)cc(OC)c1OC CHEMBL1984711 pKi 501.19 nM
COc1cccc(CNC(=O)c2cc3c(-c4ccccc4)n[nH]c3s2)c1 CHEMBL1987009 pKi 501.19 nM
Nc1ncc(C=CC(=O)NCCCn2ccnc2)c2scc(-c3ccc(Br)cc3)c12 CHEMBL1994938 pKi 501.19 nM
Clc1cc(NC2CCCCC2)nc(-c2c[nH]c3ncccc23)n1 CHEMBL1997846 pKi 501.19 nM
Cc1ccc(Nc2nc3ccc([N+](=O)[O-])cc3[nH]2)nc1 CHEMBL1992937 pKi 501.19 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(C=Cc3ccccc3)n2)n[nH]1 CHEMBL1983923 pKi 501.19 nM
CSc1ccccc1CNc1ncc([N+](=O)[O-])c(NCC2CCC(CN)CC2)n1 CHEMBL392642 pKi 501.19 nM
Cn1c(Nc2ccc(C(F)(F)F)cc2)nc2cc(Oc3ccnc(-c4ncc(C(F)(F)F)[nH]4)c3)ccc21 CHEMBL558752 Kd 510.0 nM
COc1ccccc1C1=C(Nc2cccc(OCc3ccccc3)c2)C(=O)NC1=O CHEMBL4879311 Ki 510.0 nM
COc1ccc(-c2ccsc2)cc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O CHEMBL4870533 Ki 520.0 nM
CO[C@@H](C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 CHEMBL402548 IC50 621.0 nM
CN(C)c1ccc(-c2cc3ncccc3c(NCCCCN)n2)cc1 CHEMBL282342 Kd 623.0 nM
CSc1c[nH]c2ncnc(NCCCO)c12 CHEMBL2000114 pKi 630.96 nM
COc1ccc2c(c1)C(=Cc1c[nH]cn1)C(=O)N2 CHEMBL2002649 pKi 630.96 nM
Cc1ccc(-c2cc3c(NCCN)ccc(C(N)=O)c3[nH]2)cc1 CHEMBL1996048 pKi 630.96 nM
CN(C)c1ccc(CNC(=O)c2cc3c(-c4ccccc4)n[nH]c3s2)cc1 CHEMBL1984367 pKi 630.96 nM
O=C(NCc1ccc(Cl)cc1)c1cc2c(-c3ccccc3)n[nH]c2s1 CHEMBL1967094 pKi 630.96 nM
NC(=O)c1cc2c(Oc3cccc(F)c3)cncc2s1 CHEMBL1964777 pKi 630.96 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cnc4c(-c5cnn(C)c5)cnn4c3N)cc2)c1 CHEMBL508928 pKi 630.96 nM
CCC(N)(C#Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12)CC CHEMBL1983025 pKi 630.96 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL5416410 pKi 630.96 nM
COc1cccc(C(C)NC(=O)c2cc(C)c(-c3ccc4[nH]nc(C)c4c3)s2)c1 CHEMBL1997534 pKi 630.96 nM
COc1cccc(C(C)NC(=O)N2CC=C(c3c[nH]c4ncccc34)CC2)c1 CHEMBL1965845 pKi 630.96 nM
O=c1[nH]c2cnc(-n3cnc4ccc(F)cc43)nc2n1C1CCOc2c(F)cccc21 CHEMBL2000393 pKi 630.96 nM
COc1ccc(-c2ccc(NC(=O)Nc3cccc(Br)c3)cc2)c2c(N)noc12 CHEMBL271381 pKi 630.96 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 Kd 680.0 nM
COc1ccc(-c2cccnc2)cc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O CHEMBL4869999 Ki 680.0 nM
Cc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Cl)[nH]n1 CHEMBL1231124 Kd apparent 686.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 720.0 nM
COc1cc(-c2cccc3c2OCCO3)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O CHEMBL4855005 Ki 720.0 nM
COc1cccc(C2=C(Nc3cccc(O)c3)C(=O)NC2=O)c1 CHEMBL160373 Ki 740.0 nM
COc1cccc(C(=O)Nc2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982924 pKi 794.33 nM
CCC1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc2N1C1CCCC1 CHEMBL1968380 pKi 794.33 nM
O=C(Nc1cnc2[nH]cc(-c3ccccc3)c2c1)c1c(F)cccc1F CHEMBL1996979 pKi 794.33 nM
Nc1ncnc2c1c(I)nn2C1CCC(O)CC1 CHEMBL1996791 pKi 794.33 nM
COc1ccc(-c2cc3nccn3c(Nc3ncccc3C(N)=O)n2)cc1OC CHEMBL1190711 pKi 794.33 nM
CN1CCN(c2ccc(-c3cnc4c(c3)N(Cc3c(F)ccc(F)c3Cl)CCN4)cn2)CC1 CHEMBL1164265 pKi 794.33 nM
O=c1nc(-c2cc3c(Oc4ccc(I)cc4)cncc3s2)[nH]o1 CHEMBL497151 pKi 794.33 nM
CCN1CCN(c2ccc(Nc3nccc(-c4c(-c5cccc(C(=O)Nc6ccccc6F)c5)nc5ccccn45)n3)cc2)CC1 CHEMBL1981725 pKi 794.33 nM
c1ccc(Nc2nc(-c3ccc4[nH]ncc4c3)cs2)cc1 CHEMBL1682545 pKi 794.33 nM
CCCCn1c(NC(=O)c2ccc(C#N)cc2)nc2cc(N(C)C(=O)C3CCCCC3)ccc21 CHEMBL484390 pKi 794.33 nM
Nc1ncnc(Nc2cc(CNC(=O)C(F)(F)F)c(O)c(-c3ccc(Cl)cc3)c2)n1 CHEMBL2001239 pKi 794.33 nM
Cc1[nH]c(C=C2C(=O)Nc3ccccc32)c(C)c1CCC(=O)O CHEMBL2007064 pKi 794.33 nM
Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c12 CHEMBL1976220 pKi 794.33 nM
COc1ccc(-c2cccc3c2OCCO3)cc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O CHEMBL4857914 Ki 840.0 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccc(F)cc23)c1 CHEMBL5404639 IC50 892.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1336 Kd 1000.0 nM
CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL1289926 Kd 1000.0 nM
CN(C)c1cc2sncc2cc1NC(=O)C(=O)O CHEMBL1997023 pKi 1000.0 nM
Cc1ccccc1NC(=O)Nc1ccc2c(c1)CCc1sc3ncnc(N)c3c1-2 CHEMBL1982135 pKi 1000.0 nM
Nc1ncnc2c1sc1ncnc(N)c12 CHEMBL1976090 pKi 1000.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4ccnc(N)c34)cc2)c1 CHEMBL394619 pKi 1000.0 nM
Fc1cnc(Nc2ccccc2)nc1Nc1ccccc1 CHEMBL491758 pKi 1000.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 1000.0 nM
O=C1NCc2c1cccc2-c1ccc(Nc2nc3ccccc3[nH]2)cc1 CHEMBL1979057 pKi 1000.0 nM
Cn1cc(C=C2C(=O)Nc3cccnc32)c2ccccc21 CHEMBL1516890 pKi 1000.0 nM
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)c1 CHEMBL1090356 pKi 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM