Nc1nnc(-c2ccccc2O)cc1N1CC2CCC(C1)N2c1cccc(OCCN2CCN(CC3CCN(c4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)c1 CHEMBL5088656 DC50 2.0 nM
Nc1nnc(-c2ccccc2O)cc1N1CC2CCC(C1)N2c1cccc(OCCN2CCN(CCCC3CCN(c4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)c1 CHEMBL5083814 DC50 2.0 nM
Nc1nnc(-c2ccccc2O)cc1N1CCCC1 CHEMBL5415064 Kd 2.0 nM
Nc1nnc(-c2ccccc2O)cc1N1CC(Oc2cccc(CN3CCN(C(=O)CN4CCC(c5ccc(NC6CCC(=O)NC6=O)cc5)CC4)CC3)c2)C1 CHEMBL5083352 DC50 3.0 nM
Nc1nnc(-c2cc(F)ccc2O)cc1N1CC2CCC(C1)N2c1cccc(CN2CCN(C(=O)C3CCN(c4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)c1 CHEMBL5080061 DC50 3.0 nM
Nc1nnc(-c2ccccc2O)cc1N1CCC(C(=O)N2CCC(C(=O)N3CCN(c4ccc(C5CCC(=O)NC5=O)cc4)CC3)CC2)(c2ccccc2)CC1 CHEMBL5088883 DC50 3.0 nM
C[C@H]1CN(C(=O)OC(C)(C)C)CCN1c1cc(-c2ccccc2O)nnc1N CHEMBL5412292 Kd 3.0 nM
Nc1nnc(-c2ccccc2O)cc1N1CCN(c2cccc(CN3CCN(C(=O)C4CCN(c5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)CC3)c2)C2(CC2)C1 CHEMBL5088261 DC50 4.0 nM
O=C(Nc1ccnc(Cl)c1)Nc1cc(C(F)F)ns1 CHEMBL4278436 IC50 5.0 nM
O=C(Nc1ccnc(Cl)c1)Nc1cc(C(F)(F)F)ns1 CHEMBL4294655 IC50 10.0 nM
Cn1cc(-c2cc(-c3ccccc3O)nnc2N)cn1 CHEMBL5420238 Kd 10.0 nM
CC(C)[C@H]1CCCN1c1cc(-c2ccccc2O)nnc1N CHEMBL5409404 Kd 13.0 nM
COC[C@H](NC(=O)c1ccn(S(C)(=O)=O)c1)C(=O)Nc1nc(-c2cccc(-c3ccn(C)n3)c2)cs1 CHEMBL5308262 IC50 13.8 nM
CC(=O)N1CCN(c2cc(-c3ccccc3O)nnc2N)C[C@H]1C CHEMBL5207330 Kd 16.0 nM
O=C(/C=C/N1C[C@H]2C[C@@H]1CN2c1ccccn1)c1ccccc1O CHEMBL3752911 Kd 18.0 nM
C[C@H]1CCCCN1c1cc(-c2ccccc2O)nnc1N CHEMBL5428009 Kd 20.0 nM
C[C@H]1CCCN1c1cc(-c2ccccc2O)nnc1N CHEMBL5401472 Kd 20.0 nM
CC(=O)N1CCN(c2cc(-c3ccccc3O)nnc2N)[C@@H](C)C1 CHEMBL5398829 Kd 20.0 nM
C[C@@H]1CCCCN1c1cc(-c2ccccc2O)nnc1N CHEMBL5411199 Kd 24.0 nM
CC[C@H]1CCCN1c1cc(-c2ccccc2O)nnc1N CHEMBL5406315 Kd 30.0 nM
C[C@@H]1CCCN1c1cc(-c2ccccc2O)nnc1N CHEMBL5425250 Kd 32.0 nM
Cc1cc(NC(=O)Nc2ccnc(Cl)c2)sn1 CHEMBL4286757 IC50 33.0 nM
CC(C)(C)OC(=O)N1CCN(c2cc(-c3ccccc3O)nnc2N)CC1 CHEMBL4780617 Kd 35.0 nM
Nc1nnc(-c2ccccc2O)cc1-c1ccccc1 CHEMBL5177096 IC50 37.0 nM
O=C(/C=C/N1[C@H]2CC[C@@H]1c1ncnc(NC3CC3)c1C2)c1ccccc1O CHEMBL3818070 Kd 37.3 nM
Nc1nnc(-c2ccccc2O)cc1N1CCC[C@@H]1C1CC1 CHEMBL5431862 Kd 40.0 nM
O=c1nc2n(C3CCCC3)c3cc(C4CCNCC4)ccc3n2c2cccc(Br)c12 CHEMBL5395133 Kd 46.0 nM
O=C(Nc1ccnc(Cl)c1)Nc1ccnc(C(F)(F)F)c1 CHEMBL4290175 IC50 60.0 nM
Nc1nnc(-c2ccccc2O)cc1N1CCC(O)CC1 CHEMBL4793170 Kd 69.0 nM
Nc1nnc(-c2ccccc2O)cc1N1CCC[C@@H](O)C1 CHEMBL4790365 Kd 71.0 nM
O=C(Nc1ccncc1)Nc1ccnc(Cl)c1 CHEMBL4290675 Kd 87.0 nM
Nc1nnc(-c2ccccc2O)cc1N1CCCCC1 CHEMBL5424811 Kd 90.0 nM
O=C(Nc1ccnc(Cl)c1)Nc1ccnc(C(F)F)c1 CHEMBL4279505 IC50 110.0 nM
Nc1nnc(-c2ccccc2O)cc1N1CCNCC1 CHEMBL4746865 Kd 135.0 nM
Cc1cc(NC(=O)Nc2ccnc(Cl)c2)ccn1 CHEMBL4281368 IC50 200.0 nM
CN1CCN(/C=C2\CCn3c2nc(=O)c2c(Cl)cccc23)CC1 CHEMBL3822689 Kd 262.0 nM
Nc1nnc2c([nH]c3ccccc32)c1-c1ccccc1 CHEMBL5183240 Kd 340.0 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@H]2C[C@H](O)CN2C(=O)[C@H](NC(=O)C2(F)CC2)C(C)(C)C)c(OCCOc2ccc(CN3CCN(c4cc(-c5ccccc5O)nnc4N)CC3)cc2)c1 CHEMBL5278697 IC50 770.0 nM
Cc1csc(NC(=O)Nc2ccnc(Cl)c2)n1 CHEMBL4282784 IC50 970.0 nM
Cc1[nH]c(-c2cc(NS(C)(=O)=O)ccc2Oc2ccccc2)c2c1C(=O)CCC2 CHEMBL4063051 IC50 1000.0 nM