Cc1cc(C)c(-c2ncc[nH]2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 CHEMBL4632769 IC50 0.08 nM
Cc1cc(C)c(-c2cn(C)cn2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 CHEMBL4637222 IC50 0.2 nM
Cc1ccc(-c2nnc(N3CCN(C(=O)c4ccccc4)C[C@H]3C)c3ccccc23)cc1 CHEMBL1083915 IC50 0.4 nM
CS(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)c(-c3ccccn3)c2)c(Cl)c1 CHEMBL473417 IC50 0.4 nM
C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccc(Cl)cc2)c2ccccc12 CHEMBL1086467 IC50 0.7 nM
C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccc(C(F)(F)F)cc2)c2ccncc12 CHEMBL1209455 IC50 1.0 nM
CC1=C2C[C@H]3[C@@H](CC[C@@H]4C[C@H](NS(C)(=O)=O)CC[C@@]43C)[C@@H]2CC[C@@]2(C1)O[C@@H]1C[C@H](C)CN[C@H]1[C@H]2C CHEMBL538867 IC50 1.4 nM
C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccccc2)c2ccccc12 CHEMBL1084835 IC50 2.2 nM
C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccc(C3CC3)cc2)c2ccccc12 CHEMBL1084730 IC50 2.3 nM
Cc1ccc(-c2ncc(C(F)(F)F)[nH]2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 CHEMBL2059863 IC50 2.4 nM
Cc1ccc(-c2ncc[nH]2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 CHEMBL2059865 IC50 2.4 nM
Cc1cnc(-c2ccc(C)c(NC(=O)c3ccc(OCc4ccccn4)cc3)c2)[nH]1 CHEMBL2059864 IC50 2.6 nM
C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccc(CO)cc2)c2ccccc12 CHEMBL1084734 IC50 2.7 nM
C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccc(C(F)(F)F)cc2)c2ccccc12 CHEMBL1084738 IC50 2.8 nM
Cn1c(-c2noc(N3CCN(C(=O)NC4CCCCC4)CC3)n2)nc2ccccc21 CHEMBL1823863 IC50 3.0 nM
C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccc(C#N)cc2)c2ccccc12 CHEMBL1084736 IC50 3.1 nM
Cc1ccc(-c2nnc(N3CCN(C(=O)c4ccccc4)[C@@H](C)C3)c3ccccc23)cc1 CHEMBL1083284 IC50 3.2 nM
CC(=O)Oc1ccc(-c2nnc(N3CCN(C(=O)c4ccccc4)C[C@H]3C)c3ccccc23)cc1 CHEMBL1209189 IC50 3.3 nM
C[C@H]1CN(c2nnc(-c3ccc(C(F)(F)F)cc3)c3ccccc23)CCN1C(=O)c1ccccc1 CHEMBL1083914 IC50 3.6 nM
Cc1ccc(NCc2ccnn2-c2nnc(N3CCC(C(=O)NC4CCCCC4C)CC3)s2)nc1 CHEMBL4441310 IC50 3.9 nM
O=C(Nc1cccnc1-c1cccc(Cl)c1)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)[C@@H]2C1 CHEMBL1813106 IC50 4.0 nM
C[C@@H]1CN(c2ccc3c(Nc4ccc(Cl)c(-c5ncc(-c6ccccc6)[nH]5)c4)nccc3n2)CCO1 CHEMBL2160067 IC50 4.0 nM
CN(C(=O)c1ccc(F)cc1C(F)(F)F)C1CCN(c2nnc(-c3ccnn3C)c3ccccc23)CC1 CHEMBL2142592 IC50 4.17 nM
Cc1ccc(-c2nnc(N3CCN(C(=O)c4ccccc4)CC3)c3ccccc23)cc1 CHEMBL1085503 IC50 4.4 nM
Cc1nn(-c2ccccc2)c(C)c1/C=N/N1CCN(Cc2ccccc2)CC1 CHEMBL515916 IC50 4.74 nM
C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccc(CC(N)=O)cc2)c2ccccc12 CHEMBL1209190 IC50 4.8 nM
CCCC(CCC)C(=O)NCc1ccc2c(cnn2-c2ccccc2OC)c1 CHEMBL561533 IC50 5.0 nM
COc1cccc(N2CCN(Cc3cnn(-c4ccc(F)cc4)c3C)CC2)c1 CHEMBL1209156 IC50 5.0 nM
N#Cc1cccc(-c2ncccc2NC(=O)N2CCN3C(=O)N([C@H]4C[C@@H]4c4ccccc4)C(=O)[C@@H]3C2)c1 CHEMBL1813107 IC50 5.0 nM
Cn1c(-c2noc(N3CCN(C(=O)NCC4(N5CCCCC5)CCCC4)CC3)n2)nc2ccccc21 CHEMBL1822467 IC50 5.0 nM
COc1cc(C(=O)NC(=N)Nc2ccc(C)c(NC(=O)c3ccc(-c4ccccc4)cc3)c2)cc(OC)c1OC CHEMBL2031290 IC50 5.0 nM
Cc1ccc(-c2nc3ccccc3[nH]2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 CHEMBL2059859 IC50 5.0 nM
Cc1ccc(-c2cn(C)cn2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 CHEMBL2059866 IC50 5.0 nM
C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccc(N(C)C)cc2)c2ccccc12 CHEMBL1084737 IC50 5.2 nM
O=C(c1ccccc1)N1CCN(c2nnc(-c3ccc(Cl)cc3)c3ccccc23)CC1 CHEMBL1084837 IC50 5.2 nM
C[C@H]1CN(c2nnc(-c3ccccc3)c3ccccc23)CCN1C(=O)c1ccccc1 CHEMBL1086045 IC50 5.3 nM
C[C@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccccc2)c2ccccc12 CHEMBL1086048 IC50 5.3 nM
CC(=O)Nc1nc2ccc(-c3cnc(Cl)c(NC(=O)c4ccccc4)c3)cc2s1 CHEMBL3604610 IC50 5.6 nM
C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccccc2)c2ccncc12 CHEMBL1209454 IC50 5.8 nM
Cc1cnc(-c2cc(N3CCN(C(=O)CCS(C)(=O)=O)CC3)ncc2Cl)c(C)c1 CHEMBL3186656 IC50 5.8 nM
O=C(Nc1ccnn1-c1cccc(F)c1)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)[C@@H]2C1 CHEMBL1813111 IC50 6.0 nM
Cc1c(C(=O)Nc2ccc(N3C[C@@H](C)O[C@@H](C)C3)nc2)cccc1-c1ccc(OC(F)(F)F)cc1 CHEMBL2105737 Ki 6.0 nM
O=C(Nc1ccc(-c2cccc(-c3ccccc3)c2)cc1)c1ccccc1Cl CHEMBL1824915 IC50 6.4 nM
Cc1cnc(-c2cc(N3CCC(NS(C)(=O)=O)CC3)ncc2Cl)c(C)c1 CHEMBL3692719 IC50 6.4 nM
Cc1cccc(C(=O)Nc2ccc3c(c2)C[C@@H](NCc2cccs2)C3)c1-c1ccc(C(F)(F)F)cc1 CHEMBL474503 IC50 7.0 nM
Cc1csc(CN[C@H]2Cc3ccc(NC(=O)c4cccc(C)c4-c4ccc(C(F)(F)F)cc4)cc3C2)n1 CHEMBL474507 IC50 7.0 nM
C[C@H]1CN(c2nnc(-c3ccc(Cl)cc3)c3ccccc23)CCN1C(=O)c1ccccc1 CHEMBL1083285 IC50 7.0 nM
Cn1c(-c2noc(N3CCN(C(=O)NC4CCC(F)(F)CC4)CC3)n2)nc2ccccc21 CHEMBL1823864 IC50 7.0 nM
Cc1nc(-c2ccc(C)c(NC(=O)c3ccc(OCc4ccccn4)cc3)c2)c[nH]1 CHEMBL2059867 IC50 7.0 nM
Cc1cc(F)cnc1-c1cc(N2CCN(C(=O)CCS(C)(=O)=O)CC2)ncc1Cl CHEMBL3696808 IC50 7.11 nM
O=C(Nc1ccc(-c2cc(-c3ccccc3)ccn2)cc1)c1ccccc1Cl CHEMBL1824916 IC50 7.2 nM
CC(C)c1ccc(-c2nnc(N3CCN(C(=O)c4ccccc4)C[C@H]3C)c3ccccc23)cc1 CHEMBL1084731 IC50 7.3 nM
CC(C)(O)c1ccc(N2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)nc1 CHEMBL485870 IC50 8.0 nM
C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-n2ccc3ccccc32)c2ccccc12 CHEMBL1209314 IC50 8.0 nM
O=C(Nc1ccnn1-c1cccc(Cl)c1)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)[C@@H]2C1 CHEMBL1813110 IC50 8.0 nM
O=C(NCC1(N2CCCCC2)CCCC1)N1CCN(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1822466 IC50 8.0 nM
Cc1ccc(-c2c(C)nn(C)c2C)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 CHEMBL2059870 EC50 8.0 nM
Cc1ccc(-c2ccc(N)nn2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 CHEMBL2057336 EC50 8.0 nM
C[C@@H]1CN(c2ccc(C(=O)Nc3ccc(Cl)c(NC(=O)c4cccc(Cl)c4)c3)cn2)C[C@H](C)N1 CHEMBL5185871 IC50 8.0 nM
COc1cccc(F)c1OC1CN(Cc2cnn(-c3ccccc3)c2C)C1 CHEMBL1209158 IC50 8.27 nM
C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-n2cccc2)c2ccccc12 CHEMBL1209251 IC50 8.7 nM
Cc1ccc(-c2[nH]cnc2C)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 CHEMBL2059868 IC50 9.0 nM
Cc1ccc(-c2cc(C(F)(F)F)n[nH]2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 CHEMBL2059871 IC50 9.0 nM
O=C(c1nccs1)N1CCN(c2nnc(-c3ccccc3)c3ccccc23)CC1 CHEMBL1083104 IC50 9.5 nM
Cc1cccnc1-c1cc(N2CCN(C(=O)CCS(C)(=O)=O)CC2)ncc1Cl CHEMBL3696752 IC50 9.84 nM
Cc1ccc(CN[C@H]2Cc3ccc(NC(=O)c4cccc(C)c4-c4ccc(C(F)(F)F)cc4)cc3C2)o1 CHEMBL471672 IC50 10.0 nM
Cc1nn(-c2ccccc2)c(Cl)c1CN1CCN(c2ccc(F)cc2)CC1 CHEMBL1209095 IC50 10.0 nM
O=C(NCC1(N2CCOCC2)CCCC1)N1CCN(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1822465 IC50 10.0 nM
CC(=O)Nc1nc2ccc(-c3cnc(Cl)c(NC(=O)c4cccc(Cl)c4)c3)cc2s1 CHEMBL3604612 IC50 10.0 nM
COc1cc(C(=O)NC(=N)Nc2cccc(NC(=O)c3ccc(-c4ccccc4)cc3)c2)cc(OC)c1OC CHEMBL4159710 IC50 10.0 nM
C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccc(C(C)(C)C)cc2)c2ccccc12 CHEMBL1084733 IC50 10.1 nM
O=C(Nc1ccc(Cl)c(-c2nnc3c(Cl)cccn23)c1)c1ccc(Cl)nc1Cl CHEMBL4637406 Kd 10.3 nM
Cc1cc(F)cnc1-c1cc(N2CCC(NS(=O)(=O)CC(C)(C)O)CC2)ncc1Cl CHEMBL3696810 IC50 10.6 nM
O=C(Nc1ccc(Cl)c(-c2nnc3c(Cl)cccn23)c1)c1ccc(C(F)(F)F)nc1Cl CHEMBL4645977 Kd 10.6 nM
O=C(c1ccccc1)N1CCN(c2nnc(-c3ccc(F)cc3)c3ccccc23)CC1 CHEMBL1083739 IC50 10.8 nM
Cc1ccc(-c2ncc(C)n2C)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 CHEMBL2059862 EC50 11.0 nM
Cc1cnc(-c2cc(N3CCC(CS(N)(=O)=O)CC3)ncc2Cl)c(C)c1 CHEMBL3696776 IC50 11.1 nM
Cc1cc(F)cnc1-c1cc(N2CCN(S(=O)(=O)CC(C)(C)O)CC2)ncc1Cl CHEMBL3696809 IC50 11.4 nM
Cc1cnc(-c2cc(N3CCC(NS(=O)(=O)C4CC4)CC3)ncc2Cl)c(C)c1 CHEMBL3696785 IC50 11.5 nM
CCS(=O)(=O)NC1CCN(c2cc(-c3ncc(C)cc3C)c(Cl)cn2)CC1 CHEMBL3696779 IC50 11.6 nM
Cc1cnc(-c2ccnc(N3CCN(C(=O)CCS(C)(=O)=O)CC3)c2)c(C)c1 CHEMBL3696798 IC50 11.6 nM
C[C@H]1CN(c2nnc(-c3ccc(F)cc3)c3ccccc23)CCN1C(=O)c1ccccc1 CHEMBL1083605 IC50 11.8 nM
C[C@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccc(F)cc2)c2ccccc12 CHEMBL1209074 IC50 12.0 nM
C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccccc2)c2cnccc12 CHEMBL1209381 IC50 12.0 nM
O=C(Nc1cccnc1-c1ccccc1)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1807222 IC50 12.0 nM
O=C(Nc1cccnc1-c1ccccc1)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)[C@@H]2C1 CHEMBL1813105 IC50 12.0 nM
Cc1cnc(-c2ccnc(N3CCN(C(=O)CN4C[C@@H](C)O[C@@H](C)C4)CC3)c2)c(C)c1 CHEMBL3696813 IC50 12.1 nM
Cc1cnc(-c2ccnc(N3CCC(NS(C)(=O)=O)CC3)c2)c(C)c1 CHEMBL3696800 IC50 12.2 nM
CC1=C2C[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]2CC[C@]12O[C@@H]1C[C@H](C)CN[C@H]1[C@H]2C CHEMBL254129 Kd 12.4 nM
Cc1cnc(-c2cc(N3CCC(CS(C)(=O)=O)CC3)ncc2Cl)c(C)c1 CHEMBL3696757 IC50 12.4 nM
C[C@@H]1CN(c2nnc(-c3ccccc3)c3ccccc23)CCN1C(=O)c1ccccc1 CHEMBL1086284 IC50 13.0 nM
O=C(c1ccco1)N1CCN(c2nnc(-c3ccccc3)c3ccccc23)CC1 CHEMBL1083103 IC50 13.0 nM
O=C(Nc1ccnn1-c1ccccc1)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1807231 IC50 13.0 nM
C[C@@]12CN(C(=O)Nc3ccnn3-c3ccccc3)CCN1C(=O)N([C@H]1C[C@@H]1c1ccccc1)C2=O CHEMBL1813114 IC50 13.0 nM
O=C(NC1CCC(F)(F)CC1)N1CCN(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1822468 IC50 13.0 nM
O=C(Nc1ccc(NC(=O)c2ccccc2Cl)cc1)c1ccccc1 CHEMBL1824904 IC50 13.0 nM
COc1cc(C(=O)NC(=O)Nc2ccc(C)c(NC(=O)c3ccc(-c4ccccc4)cc3)c2)cc(OC)c1OC CHEMBL2031277 IC50 13.0 nM
Cc1cccc(C(=O)Nc2ccc3c(c2)C[C@@H](NCc2ccccc2)C3)c1-c1ccc(C(F)(F)F)cc1 CHEMBL473896 IC50 14.0 nM
O=C(Nc1ccc(CC(O)c2ccccc2)cc1)c1ccccc1Cl CHEMBL1824905 IC50 14.0 nM
COc1cc(C(=O)NC(=N)Nc2ccc(C)c(NC(=O)c3ccc(-c4ccc(F)cc4)cc3)c2)cc(OC)c1OC CHEMBL2031288 IC50 14.0 nM
Cc1cnc(-c2cc(N3CCC(NC(=O)CCS(C)(=O)=O)CC3)ncc2Cl)c(C)c1 CHEMBL3696780 IC50 14.7 nM
Cc1cnc(-c2ccnc(N3CCN(C(=O)CN4CCOCC4)CC3)c2)c(C)c1 CHEMBL3696814 IC50 14.8 nM
CC(C)(N)c1ccc(N2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)nc1 CHEMBL497266 IC50 15.0 nM
Cc1ccccc1-c1nnc(N2CCN(C(=O)c3ccccc3)CC2)c2ccccc12 CHEMBL1082387 IC50 15.0 nM
COc1ccc(-c2nnc(N3CCN(C(=O)c4ccccc4)CC3)c3ccccc23)cc1 CHEMBL1083738 IC50 15.0 nM
O=C(Nc1ccnn1-c1ccccc1)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)[C@@H]2C1 CHEMBL1813109 IC50 15.0 nM
Cn1c(-c2noc(C3CCN(C(=O)NCC4(N5CCOCC5)CCCC4)CC3)n2)nc2ccccc21 CHEMBL1822463 IC50 15.0 nM
O=S(=O)(CCO)NC1CCN(c2ccc(Cl)c(-c3ccccn3)n2)CC1 CHEMBL3696784 IC50 15.2 nM
C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccccc2)c2cccnc12 CHEMBL1209380 IC50 16.0 nM
CC(C)NC1(CNC(=O)N2CCC(c3nc(-c4ccc5ccccc5n4)no3)CC2)CCCC1 CHEMBL1822447 IC50 16.0 nM
O=S(=O)(NC1CCN(c2ccc(Cl)c(-c3ccccn3)n2)CC1)C1CC1 CHEMBL3696791 IC50 16.5 nM
C[C@H]1CN(c2ccc(C#N)cn2)CCN1c1nnc(Cc2ccccc2)c2ccccc12 CHEMBL497238 IC50 17.0 nM
O=C(c1ccccc1)N1CCN(c2nnc(-c3ccc(Cl)c(Cl)c3)c3ccccc23)CC1 CHEMBL1084836 IC50 17.0 nM
Cc1ccc(-c2ccccn2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 CHEMBL2059875 EC50 17.0 nM
Cc1ccc(-c2nc(N3CCC(NS(C)(=O)=O)CC3)ccc2Cl)nc1 CHEMBL3696775 IC50 17.0 nM
Cc1cccnc1-c1ccnc(N2CCC(NS(C)(=O)=O)CC2)n1 CHEMBL3692755 IC50 17.7 nM
Cc1cnc(-c2c(Cl)cnc(N3CCC(NC(=O)CCS(C)(=O)=O)CC3)c2F)c(C)c1 CHEMBL3696796 IC50 17.8 nM
O=C(Nc1cccnc1-c1cccc(Cl)c1)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1807225 IC50 18.0 nM
Cc1ccc(-c2nccn2C)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 CHEMBL2059861 EC50 18.0 nM
Cn1c(-c2cc(N3CCc4sc(C(=O)N5CCOCC5)cc4C3)ccc2Cl)nc2ccccc21 CHEMBL3818447 IC50 18.0 nM
Cc1ccc(NCc2ccnn2-c2nnc(N3CCC(C(=O)NC4CCCCC4C)CC3)s2)cc1 CHEMBL4532846 IC50 18.0 nM
Cc1cccnc1-c1cc(N2CCC(NS(C)(=O)=O)CC2)ncc1Cl CHEMBL3692713 IC50 18.7 nM
CS(=O)(=O)NC1CCN(c2cc(-c3ncc(Cl)cc3Cl)c(Cl)cn2)CC1 CHEMBL3692717 IC50 18.8 nM
O=C(c1ccccc1)N1CCN(c2nnc(-c3ccccc3)c3ccccc23)CC1 CHEMBL1082791 IC50 19.0 nM
C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccc(C(N)=O)cc2)c2ccccc12 CHEMBL1209132 IC50 19.0 nM
C[C@@]12CN(C(=O)Nc3ccccc3-c3ccccc3)CCN1C(=O)N([C@H]1C[C@@H]1c1ccccc1)C2=O CHEMBL1813113 IC50 19.0 nM
Cn1c(-c2noc(C3CCN(C(=O)NCC4(N5CCCCC5)CCCC4)CC3)n2)nc2ccccc21 CHEMBL1822464 IC50 19.0 nM
O=C(NC(=O)c1ccc(OCc2ccccc2F)cc1)Nc1ccc(Cl)c(-c2nc3ccccc3[nH]2)c1 CHEMBL3741651 IC50 19.0 nM
Cc1cnc(-c2cc(N3CCC(NC(=O)CN(C)C)CC3)ncc2Cl)c(C)c1 CHEMBL3696773 IC50 19.2 nM
Cc1cnc(-c2cc(N3CCN(C(=O)CC(C)(C)O)CC3)ncc2Cl)c(C)c1 CHEMBL3696762 IC50 19.4 nM
COc1cccc(-c2nnc(N3CCN(C(=O)c4ccccc4)CC3)c3ccccc23)c1 CHEMBL1083740 IC50 20.0 nM
COc1cccc(N2CCN(Cc3c(C)nn(-c4ccc(F)cc4)c3C)CC2)c1 CHEMBL1209048 IC50 20.0 nM
O=C(c1ccccc1)N1CCN(c2nnc(-c3ccccc3Cl)c3ccccc23)CC1 CHEMBL1082396 IC50 20.3 nM
Cc1cnc(-c2cc(N3CCN(C(=O)CCS(C)(=O)=O)CC3)ncc2F)c(C)c1 CHEMBL3696799 IC50 20.4 nM
Cc1cc(Cl)cnc1-c1cc(N2CCC(NS(C)(=O)=O)CC2)ncc1Cl CHEMBL3696768 IC50 20.5 nM
Cc1cccnc1-c1nc(N2CCC(NS(C)(=O)=O)CC2)ccc1Cl CHEMBL3692721 IC50 20.6 nM
Cc1cc(F)cnc1-c1cc(N2CCC(NS(=O)(=O)CCO)CC2)ncc1Cl CHEMBL3696806 IC50 20.7 nM
Cc1cc(F)cnc1-c1cc(N2CCC(NS(C)(=O)=O)CC2)ncc1Cl CHEMBL3696767 IC50 20.8 nM
OC1(c2ccc(N3CCN(c4nnc(Cc5ccccc5)c5ccccc45)CC3)nc2)CC1 CHEMBL519219 IC50 21.0 nM
C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccc(N3CCOCC3)cc2)c2ccccc12 CHEMBL1209133 IC50 21.0 nM
O=C(Nc1ccccc1-c1ccccc1)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)[C@@H]2C1 CHEMBL1813096 IC50 21.0 nM
O=C(Nc1cccnc1-c1ccsc1)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)[C@@H]2C1 CHEMBL1813108 IC50 21.0 nM
Cc1ccc(-c2cn(C)c(C)n2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 CHEMBL2059869 IC50 21.0 nM
Cc1cccnc1-c1cc(N2CCN(C(=O)CC(C)(C)O)CC2)ncc1Cl CHEMBL3692752 IC50 21.7 nM
Cc1ccc(-c2cccc(N3CCC(NS(C)(=O)=O)CC3)n2)nc1 CHEMBL3696774 IC50 22.0 nM
Cc1ccc(-c2nc(N3CCN(C(=O)CCS(C)(=O)=O)CC3)ccc2Cl)nc1 CHEMBL3696804 IC50 22.5 nM
O=C(NCC1(N2CCOCC2)CCCCC1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1822302 IC50 23.0 nM
Cc1cnc(-c2cc(N3CCN(S(=O)(=O)CCO)CC3)ncc2Cl)c(C)c1 CHEMBL3696770 IC50 23.3 nM
Cc1cccnc1-c1nc(N2CCC(NS(C)(=O)=O)CC2)ncc1Cl CHEMBL3692739 IC50 24.4 nM
N#Cc1ccc(N2CCN(c3nnc(Cc4ccc(Cl)cc4)c4ccccc34)CC2)nc1 CHEMBL496604 IC50 25.0 nM
C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccncc2)c2ccccc12 CHEMBL1209248 IC50 25.0 nM
Cc1cccnc1-c1cc(N2CCN(C(=O)C(C)(C)C)CC2)ncc1Cl CHEMBL3692748 IC50 25.5 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)NCC3CN(CC4CC4)C(=O)CO3)CC2)ncc1Cl CHEMBL3692778 IC50 25.5 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)NC3(CO)CCCC3)CC2)ncc1Cl CHEMBL3692780 IC50 25.8 nM
NS(=O)(=O)CC1CCN(c2ccc(Cl)c(-c3ccccn3)n2)CC1 CHEMBL3696750 IC50 26.3 nM
COCCS(=O)(=O)NC1CCN(c2ccc(Cl)c(-c3ccccn3)n2)CC1 CHEMBL3696781 IC50 26.7 nM
O=C(Nc1ccc(-c2ccnc(-c3ccccc3)n2)cc1)c1ccccc1Cl CHEMBL1824917 IC50 27.0 nM
O=C(Nc1ccc(-c2nc(-c3ccccc3)cs2)cc1)c1ccccc1Cl CHEMBL1824908 IC50 27.0 nM
O=C(Nc1ccc(-c2cncc(-c3ccccc3)c2)cc1)c1ccccc1Cl CHEMBL1824918 IC50 28.0 nM
Cc1ccc(-c2nccs2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 CHEMBL2059873 EC50 28.0 nM
C#CCOc1ccc(N2C(=O)[C@H](C)N(Cc3ccc(N=[N+]=[N-])cc3)C2=O)cc1 CHEMBL4562943 Ki 28.0 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)NC3CCCCC3O)CC2)ncc1Cl CHEMBL3692776 IC50 28.3 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)N[C@H]3CC[C@H](CO)CC3)CC2)ncc1Cl CHEMBL3696748 IC50 28.5 nM
COc1cc(C(=O)NC(=S)Nc2ccc(C)c(NC(=O)c3ccc(-c4ccc(F)cc4)cc3)c2)cc(OC)c1OC CHEMBL2031263 IC50 29.0 nM
COCCS(=O)(=O)N1CCN(c2cc(-c3ncc(C)cc3C)c(Cl)cn2)CC1 CHEMBL3696769 IC50 29.2 nM
Cc1cc(F)cnc1-c1nc(N2CCC(NS(C)(=O)=O)CC2)ccc1Cl CHEMBL3696811 IC50 29.2 nM
Cc1cc(F)cnc1-c1cc(N2CCC(NC(=O)CCS(C)(=O)=O)CC2)ncc1Cl CHEMBL3696801 IC50 29.8 nM
Cc1cccc(C(=O)Nc2ccc3c(c2)C[C@@H](NCc2nccs2)C3)c1-c1ccc(C(F)(F)F)cc1 CHEMBL474893 IC50 30.0 nM
O=C(NCC1(N2CCOCC2)CCCC1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1822294 IC50 30.0 nM
Cc1cccnc1-c1nc(N2CCC(CS(C)(=O)=O)CC2)ncc1Cl CHEMBL3696756 IC50 30.0 nM
FC(F)(F)Oc1ccc(-c2ccnc(Nc3ccc4[nH]ncc4c3)n2)cc1 CHEMBL4570165 Ki 30.0 nM
CC(C)(O)CC(=O)NC1CCN(c2ccc(Cl)c(-c3ccccn3)n2)CC1 CHEMBL3696789 IC50 30.5 nM
O=C(Nc1ccc(-c2nc(-c3ccccc3)c(C(F)(F)F)o2)cc1)c1ccccc1Cl CHEMBL1824909 IC50 31.0 nM
CS(=O)(=O)CCC(=O)NC1CCN(c2ccc(Cl)c(-c3ccccn3)n2)CC1 CHEMBL3696786 IC50 31.3 nM
Cc1cccc(C(=O)Nc2ccc3c(c2)C[C@@H](NC(C)c2ccccc2)C3)c1-c1ccc(C(F)(F)F)cc1 CHEMBL474301 IC50 32.0 nM
O=C(NCC1(N2CCCC2)CCCC1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1822304 IC50 32.0 nM
CS(=O)(=O)NC1CCN(c2cc(-c3ncccc3Cl)c(Cl)cn2)CC1 CHEMBL3692715 IC50 32.1 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)N[C@@H]3CCCC[C@H]3O)CC2)ncc1Cl CHEMBL3696740 IC50 32.6 nM
CS(=O)(=O)NC1CCN(c2cc(-c3ccc(Cl)cn3)c(Cl)cn2)CC1 CHEMBL3692716 IC50 32.9 nM
O=C(Nc1ccc(-c2cccc(-c3ccccc3)n2)cc1)c1ccccc1Cl CHEMBL1824919 IC50 33.0 nM
COc1cc(C(=O)NC(=N)Nc2cccc(NC(=O)c3ccc(-c4ccc(F)cc4)cc3)c2)cc(OC)c1OC CHEMBL2031287 IC50 33.0 nM
C[C@H]1C(=O)N(c2ccc(Cl)cc2)C(=O)N1Cc1ccccc1 CHEMBL4586057 Ki 33.0 nM
CS(=O)(=O)CCC(=O)N1CCN(c2ccc(Cl)c(-c3ccccn3)n2)CC1 CHEMBL3696758 IC50 33.1 nM
Cc1cc(F)cnc1-c1cc(N2CCN(C(=O)CC(C)(C)O)CC2)ncc1Cl CHEMBL3696805 IC50 33.4 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)NC3CCS(=O)(=O)CC3)CC2)ncc1Cl CHEMBL3696739 IC50 33.6 nM
N#Cc1ccc(Cc2nnc(N3CCN(c4ccc(C#N)cn4)CC3)c3ccccc23)cc1 CHEMBL495608 IC50 34.0 nM
C[C@@H]1CN(c2nnc(Cc3ccccc3)c3ccccc23)CCN1c1ccc(C#N)cn1 CHEMBL497437 IC50 34.0 nM
CN(C(=O)c1ccc(F)cc1C(F)(F)F)C1CCN(C(=O)c2ccccc2Nc2ccccc2)CC1 CHEMBL4632598 IC50 34.09 nM
CS(=O)(=O)NC1CCN(c2ccc(Cl)c(-c3ccccn3)n2)CC1 CHEMBL3692720 IC50 34.3 nM
O=C(Nc1ccccc1-c1ccccc1)N1CCN2C(=O)N(C3CC3c3ccccc3)C(=O)C2C1 CHEMBL1813095 IC50 35.0 nM
Cc1cccnc1-c1cc(N2CCC(CS(C)(=O)=O)CC2)ncc1Cl CHEMBL3692756 IC50 35.8 nM
Cc1cnc(-c2cc(N3CCN(S(C)(=O)=O)CC3)ncc2Cl)c(C)c1 CHEMBL3696763 IC50 36.0 nM
O=C(Nc1ccc(-c2nccc(-c3ccccc3)n2)cc1)c1ccccc1Cl CHEMBL1824920 IC50 37.0 nM
Cc1cccnc1-c1cc(N2CCC(NC(=O)CCS(C)(=O)=O)CC2)ncc1Cl CHEMBL3696754 IC50 37.0 nM
Cc1cccnc1-c1cc(N2CCN(c3ccc(C#N)cn3)CC2)ncc1Cl CHEMBL3692724 IC50 37.5 nM
O=C(NC1CCN(Cc2ccc(N3CCC(NC(=O)c4cccc(-c5cccnc5)c4)CC3)nc2)CC1)c1cccc(-c2cccnc2)c1 CHEMBL2160208 Ki 37.9 nM
CS(=O)(=O)CC1CCN(c2ccc(Cl)c(-c3ccccn3)n2)CC1 CHEMBL3692758 IC50 38.2 nM
CCS(=O)(=O)NC1CCN(c2ccc(Cl)c(-c3ccccn3)n2)CC1 CHEMBL3696790 IC50 38.2 nM
Cc1cccnc1-c1cc(N2CCC(NCCS(C)(=O)=O)CC2)ncc1Cl CHEMBL3692754 IC50 39.0 nM
Cc1ccc(-c2c[nH]cn2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 CHEMBL2059860 EC50 39.2 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)N3CCN(c4ccc(O)nn4)CC3)CC2)ncc1Cl CHEMBL3696741 IC50 39.2 nM
CCCC(CCC)C(=O)NCc1ccc2c(cnn2-c2ccc(OC)cc2)c1 CHEMBL563928 IC50 40.0 nM
O=C(Nc1ccc(-c2ncc(-c3ccccc3)o2)cc1)c1ccccc1Cl CHEMBL1824910 IC50 40.0 nM
Cc1ccc(-c2ccncc2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 CHEMBL2059876 EC50 40.0 nM
CS(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)c(C(=O)Nc3cccc(O)c3)c2)c(Cl)c1 CHEMBL3126707 IC50 40.0 nM
Cc1ccc(-c2nc(N3CCC(NS(C)(=O)=O)CC3)ccc2Br)nc1 CHEMBL3696778 IC50 40.0 nM
COCC(=O)NC1CCN(c2cc(-c3ncc(C)cc3C)c(Cl)cn2)CC1 CHEMBL3696793 IC50 40.0 nM
Cc1cccnc1-c1cc(N2CCN(c3ncc(Br)cn3)CC2)ncc1Cl CHEMBL3692751 IC50 40.3 nM
COc1ccc(OC)c(C2CCN(Cc3cnn(-c4ccccc4F)c3C)C2)c1 CHEMBL1209157 IC50 40.8 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)NCCC3C(=O)Nc4ccccc43)CC2)ncc1Cl CHEMBL3692766 IC50 40.9 nM
CS(=O)(=O)c1cc(Cl)c(NC(=O)N2CCN3C(=O)N([C@H]4C[C@@H]4c4ccccc4)C(=O)[C@@H]3C2)c(Cl)c1 CHEMBL1813104 IC50 41.0 nM
COc1cc(C(=O)NC(=S)Nc2ccc(C)c(NC(=O)c3ccc(-c4ccccc4)cc3)c2)cc(OC)c1OC CHEMBL2031268 IC50 41.0 nM
Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccccc5)cc4F)c3s2)c1 CHEMBL254760 Ki 41.7 nM
Cc1ccc(-c2ncc(CN3CCOCC3)s2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 CHEMBL2059872 IC50 42.0 nM
O=C(NC(=O)c1ccc(OCc2ccc(F)cc2)cc1)Nc1ccc(Cl)c(-c2nc3ccccc3[nH]2)c1 CHEMBL3740447 IC50 42.0 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)N(C)[C@@H]3CS(=O)(=O)C[C@H]3O)CC2)ncc1Cl CHEMBL3692774 IC50 42.4 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)N3CCCC[C@H]3CO)CC2)ncc1Cl CHEMBL3696744 IC50 42.4 nM
Cc1cccnc1-c1cc(N2CCC(NC(=O)CN(C)C)CC2)ncc1Cl CHEMBL3692736 IC50 43.4 nM
Cc1oc(-c2ccc(NC(=O)c3ccccc3Cl)cc2)nc1-c1ccccc1 CHEMBL1824911 IC50 44.0 nM
Cc1cnc(-c2cc(N3CCC(O)CC3)ncc2Cl)c(C)c1 CHEMBL3696753 IC50 44.2 nM
O=C(NC1CCCCC1)N1CCN(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1823865 IC50 45.0 nM
C[C@H]1C(=O)N(c2ccc(Cl)cc2)C(=O)N1Cc1ccc(N=[N+]=[N-])cc1 CHEMBL4539839 Ki 45.0 nM
O=C(NCC1(N2CCCCC2)CCCC1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1822442 IC50 46.0 nM
CCNC1(CNC(=O)N2CCC(c3nc(-c4ccc5ccccc5n4)no3)CC2)CCCC1 CHEMBL1822446 IC50 46.0 nM
CCN(CC)C1(CNC(=O)N2CCC(c3nc(-c4ccc5ccccc5n4)no3)CC2)CCCC1 CHEMBL1822443 IC50 46.0 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Ki 46.2 nM
CCN1CCN(c2ccc(Nc3cc(N(C)C(=O)Nc4c(Cl)c(OC)cc(OC)c4Cl)ncn3)cc2)CC1 CHEMBL1852688 Ki 46.5 nM
COc1cccc(-c2ncccc2NC(=O)N2CCN3C(=O)N([C@H]4C[C@@H]4c4ccccc4)C(=O)C3C2)c1 CHEMBL1807228 IC50 47.0 nM
Cc1cnc(-c2nc(N3CCC(NC(=O)CO)CC3)ccc2Cl)c(C)c1 CHEMBL3696797 IC50 47.7 nM
O=C(Nc1ccc(-c2cc(-c3ccccc3)ncn2)cc1)c1ccccc1Cl CHEMBL1824921 IC50 48.0 nM
O=C(Nc1ccc(/C=C/c2ccccc2)cc1)c1ccccc1Cl CHEMBL1824906 IC50 49.0 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)Nc3cnn(C)n3)CC2)ncc1Cl CHEMBL3696747 IC50 49.0 nM
CC1C(=O)N(c2ccc(Cl)cc2)C(=O)N1Cc1ccccc1 CHEMBL5276628 IC50 50.0 nM
Cc1ccc(NC(=O)CN2C(=O)/C(=N/NC(=O)c3cc(Br)ccc3O)c3ccccc32)cc1 CHEMBL4105444 Ki 50.4 nM
Cc1cc(F)cnc1-c1cc(N2CCC(NC(=O)CC(C)(C)O)CC2)ncc1Cl CHEMBL3696803 IC50 52.2 nM
COCCC(=O)N1CCN(c2cc(-c3ncccc3C)c(Cl)cn2)CC1 CHEMBL3692734 IC50 52.3 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)NC3CCOCC3)CC2)ncc1Cl CHEMBL3692781 IC50 52.5 nM
CS(=O)(=O)c1cc(Cl)c(NC(=O)N2CCN3C(=O)N([C@H]4C[C@@H]4c4ccccc4)C(=O)C3C2)c(Cl)c1 CHEMBL1808456 IC50 53.0 nM
Cc1cccnc1-c1cc(N2CCC(NC(=O)CC(C)(C)O)CC2)ncc1Cl CHEMBL3692757 IC50 54.3 nM
CN(C)CC(=O)NC1CCN(c2ccc(Cl)c(-c3ccccn3)n2)CC1 CHEMBL3696787 IC50 54.3 nM
Cc1cccc(C(=O)Nc2ccc3c(c2)C[C@@H](NC(c2ccccc2)C(F)(F)F)C3)c1-c1ccc(C(F)(F)F)cc1 CHEMBL451194 IC50 55.0 nM
C[C@H]1C(=O)N(c2ccc(N=[N+]=[N-])cc2)C(=O)N1Cc1ccccc1 CHEMBL4441183 Ki 55.0 nM
Cc1cnc(-c2cc(N3CCC(NC(=O)CO)CC3)ncc2Cl)c(C)c1 CHEMBL3696772 IC50 55.6 nM
Cn1c(-c2cc(N3CCc4sc(C(=O)Nc5cccnc5)cc4C3)ccc2Cl)nc2ccccc21 CHEMBL3819559 IC50 56.0 nM
C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccccn2)c2ccccc12 CHEMBL1209250 IC50 57.0 nM
Cc1cccnc1-c1cc(N2CCC(CNS(C)(=O)=O)CC2)ncc1Cl CHEMBL3692753 IC50 57.0 nM
Cc1cnc(-c2cc(N3CCN(C(=O)CO)CC3)ncc2Cl)c(C)c1 CHEMBL3696761 IC50 57.9 nM
Cc1ccc(-c2nc(N3CCC(NS(C)(=O)=O)CC3)ncc2Cl)nc1 CHEMBL3696777 IC50 58.9 nM
C[C@H]1CN(c2nnc(Cc3ccccc3)c3ccccc23)CCN1c1ccc(C#N)cn1 CHEMBL497436 IC50 59.0 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Ki 59.7 nM
Cc1ccc(-c2ncnc3nc[nH]c23)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 CHEMBL2057337 IC50 61.0 nM
N#Cc1cc(Cl)c(NC(=O)N2CCN3C(=O)N([C@H]4C[C@@H]4c4ccccc4)C(=O)C3C2)c(Cl)c1 CHEMBL1808457 IC50 62.0 nM
O=C(Nc1ccc(-c2nc(-c3ccccc3)co2)cc1)c1ccccc1Cl CHEMBL1824912 IC50 63.0 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)NC3(c4ccccn4)CC3)CC2)ncc1Cl CHEMBL3692760 IC50 63.3 nM
CCN1CCCCC1CNC(=O)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1822459 IC50 64.0 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)NCc3ncc[nH]3)CC2)ncc1Cl CHEMBL3692759 IC50 64.9 nM
Cc1cnc(-c2cc(N3CCN(C(=O)CCO)CC3)ncc2Cl)c(C)c1 CHEMBL3696765 IC50 65.7 nM
C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2ccccc2)c2ncccc12 CHEMBL1209379 IC50 66.0 nM
Cc1cc(F)cnc1-c1cc(N2CCC(NC(=O)CN(C)C)CC2)ncc1Cl CHEMBL3696802 IC50 66.2 nM
CC(O)c1ccc(N2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)nc1 CHEMBL485869 IC50 67.0 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)N[C@H]3CCN(S(C)(=O)=O)C3)CC2)ncc1Cl CHEMBL3692765 IC50 67.0 nM
CC(O)(CO)c1ccc(N2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)nc1 CHEMBL520858 IC50 70.0 nM
CCCC(CCC)C(=O)NCc1ccc2c(cnn2-c2cccc(C)c2)c1 CHEMBL562270 IC50 70.0 nM
COc1cc(C(=O)NC(=N)Nc2cccc(-c3cc4ccccc4[nH]3)c2)cc(OC)c1OC CHEMBL2031283 IC50 70.0 nM
COc1cc(C(=O)NC(=N)Nc2ccc(Cl)c(NC(=O)c3ccc(-c4ccccc4)cc3)c2)cc(OC)c1OC CHEMBL2031289 IC50 70.0 nM
COc1cnc(NC(=O)C2CCN(c3cc(-c4ncccc4C)c(Cl)cn3)CC2)cn1 CHEMBL3692764 IC50 71.4 nM
COC(=O)N1CCN(c2cc(-c3ncc(C)cc3C)c(Cl)cn2)CC1 CHEMBL3696760 IC50 72.4 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)N[C@H]3CC[C@@H](O)CC3)CC2)ncc1Cl CHEMBL3692775 IC50 72.9 nM
Cc1ccc(-c2cc(N3CCC(NS(C)(=O)=O)CC3)ncc2Cl)nc1 CHEMBL3692714 IC50 75.0 nM
CN(C)C(=O)c1cc(Cl)c(NC(=O)N2CCN3C(=O)N([C@H]4C[C@@H]4c4ccccc4)C(=O)[C@@H]3C2)c(Cl)c1 CHEMBL1813103 IC50 77.0 nM
COC(=O)NC1CCN(c2cc(-c3ncccc3C)c(Cl)cn2)CC1 CHEMBL3692737 IC50 77.9 nM
Cc1c(CN2CCN(c3ccccc3)CC2)cnn1-c1ccccc1 CHEMBL377200 IC50 78.4 nM
C[C@@H]1CN(C(=O)c2ccccc2)CCN1c1nnc(-c2cccnc2)c2ccccc12 CHEMBL1209249 IC50 79.0 nM
O=C(Cc1ccc(NC(=O)c2ccccc2Cl)cc1)c1ccccc1 CHEMBL1824907 IC50 79.0 nM
CCc1cc2c(c(OCC(F)(F)F)c(C(=O)NC3CCN(C(=O)CO)CC3)n2C)c(=O)n1CC(=O)c1ccccc1 CHEMBL2205230 IC50 79.0 nM
COc1cc(C(=O)NC(=O)Nc2ccc(Cl)c(NC(=O)c3ccc(-c4ccccc4)cc3)c2)cc(OC)c1OC CHEMBL2031077 IC50 80.0 nM
Cc1cc(F)cnc1-c1cc(N2CCN(S(=O)(=O)CCO)CC2)ncc1Cl CHEMBL3696807 IC50 80.9 nM
N#Cc1ccc(N2CCN(c3nnc(Cc4cccc(Cl)c4)c4ccccc34)CC2)nc1 CHEMBL521900 IC50 82.0 nM
Cc1cnc(-c2cc(N3CCN(C(=O)CN(C)C)CC3)ncc2Cl)c(C)c1 CHEMBL3696764 IC50 82.4 nM
CS(=O)(=O)NC1CCN(c2ncc(Cl)c(-c3ccccn3)n2)CC1 CHEMBL3692750 IC50 83.7 nM
O=C(Nc1ccccc1-c1ccccc1)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1808284 IC50 84.0 nM
Cc1cc(C#N)cc(Cl)c1NC(=O)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1808458 IC50 84.0 nM
CS(=O)(=O)NC1CCN(c2ncc(Cl)c(-c3ccccn3)c2F)CC1 CHEMBL3696795 IC50 84.6 nM
Cc1cnc(-c2cc(N3CCn4cc(C(=O)Nc5cccc(F)c5)nc4C3)ncc2Cl)c(C)c1 CHEMBL3262641 IC50 87.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL223360 Ki 87.6 nM
O=C(Nc1ccncc1-c1ccccc1)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1807223 IC50 88.0 nM
O=C(Nc1cccnc1-c1ccsc1)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1807229 IC50 88.0 nM
O=C(Nc1ccc(-c2nnc(-c3ccccc3)o2)cc1)c1ccccc1Cl CHEMBL1824913 IC50 89.0 nM
COc1cc(C(=O)NC(=S)Nc2cccc(NC(=O)c3ccc(-c4ccccc4)cc3)c2)cc(OC)c1OC CHEMBL2031098 IC50 90.0 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)N[C@@H]3CCN(S(C)(=O)=O)C3)CC2)ncc1Cl CHEMBL3692762 IC50 90.7 nM
CC(=O)N1CCN(c2nnc(-c3ccccc3)c3ccccc23)CC1 CHEMBL1082790 IC50 91.0 nM
Cn1c(-c2cc(N3CCc4sc(C(=O)N5CCN(c6ncccn6)CC5)cc4C3)ccc2Cl)nc2ccccc21 CHEMBL3818034 IC50 92.0 nM
Cc1cccnc1-c1cc(N2[C@@H]3CC[C@H]2CN(C(=O)CC(C)(C)O)C3)ncc1Cl CHEMBL3696766 IC50 92.2 nM
O=C(Nc1ccc(-c2ccnc(-c3ccccc3)c2)cc1)c1ccccc1Cl CHEMBL1824922 IC50 93.0 nM
O=C(Nc1ccc(-c2coc(-c3ccccc3)n2)cc1)c1ccccc1Cl CHEMBL1824914 IC50 93.0 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)Nc3cccc(CO)n3)CC2)ncc1Cl CHEMBL3692779 IC50 93.3 nM
FC(F)(F)c1ccc(N2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)nc1 CHEMBL521558 IC50 95.0 nM
Cc1cc(C#N)cnc1-c1cc(N2CCC(NS(C)(=O)=O)CC2)ncc1Cl CHEMBL3696783 IC50 95.6 nM
C[C@H]1CN(c2nnc(-c3ccncc3)c3ccccc23)CCN1C(=O)c1ccccc1 CHEMBL1082967 IC50 96.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(c3cnc(C(C)(C)O)cn3)[C@H](C)C2)c1C CHEMBL3133037 IC50 96.0 nM
COCCS(=O)(=O)N1CCN(c2cc(-c3ncc(C)cc3C)ccn2)CC1 CHEMBL3696812 IC50 97.0 nM
CCCC(CCC)C(=O)NCc1ccc2c(cnn2-c2cccc(OC)c2)c1 CHEMBL561735 IC50 100.0 nM
N#Cc1cc(Cl)c(NC(=O)N2CCN3C(=O)N([C@H]4C[C@@H]4c4ccccc4)C(=O)[C@@H]3C2)c(Cl)c1 CHEMBL1813102 IC50 100.0 nM
COc1cc(C(=O)NC(=S)Nc2cccc(NC(=O)c3ccc(-c4ccc(F)cc4)cc3)c2)cc(OC)c1OC CHEMBL2031245 IC50 100.0 nM
Cc1cccc(NC(=O)c2cc(NC(=O)c3ccc(S(C)(=O)=O)cc3Cl)ccc2Cl)c1C CHEMBL3126705 IC50 100.0 nM
COC(=O)c1cnc(N2CCN(c3nnc(Nc4ccccc4)c(C)c3C)C[C@H]2C)cn1 CHEMBL3986419 IC50 100.0 nM
Cc1c(Nc2ccccc2)nnc(N2CCN(c3cnc(C(=O)Nc4ccccc4)cn3)[C@H](C)C2)c1C CHEMBL3909290 IC50 100.0 nM
Cc1c(-c2ccc(C(F)(F)F)cc2)nnc(N2CCN(c3cnc(C(=O)O)cn3)[C@H](C)C2)c1C CHEMBL3966039 IC50 100.0 nM
Cc1c(-c2ccncc2)nnc(N2CCN(c3ccc(C(F)(F)F)cn3)CC2)c1C CHEMBL3930063 IC50 100.0 nM
Cc1c(-c2ccc(F)c(C#N)c2)nnc(N2CCN(c3ccc(C(F)(F)F)cn3)CC2)c1C CHEMBL3927351 IC50 100.0 nM
CCCCOC(=O)c1cnc(N2CCN(c3nnc(-c4cccnc4)c(C)c3C)C[C@H]2C)cc1C(F)(F)F CHEMBL3959845 IC50 100.0 nM
CCCCOC(=O)c1cnc(N2CCN(c3nnc(-c4ccc(F)nc4)c(C)c3C)C[C@H]2C)cc1C(F)(F)F CHEMBL3957159 IC50 100.0 nM
CCCCOC(=O)c1cnc(N2CCN(c3nnc(-c4ccc(C(C)C)cc4)c(C)c3C)CC2)cc1C(F)(F)F CHEMBL3959511 IC50 100.0 nM
COC(=O)c1cnc(N2CCN(c3nnc(-c4ccc(F)c(C#N)c4)c(C)c3C)C[C@H]2C)cn1 CHEMBL3977460 IC50 100.0 nM
CC(=O)N1CCN(C(=O)c2cnc(N3CCN(c4nnc(-c5ccc(C(F)(F)F)cc5)c(C)c4C)C[C@H]3C)cn2)CC1 CHEMBL3978301 IC50 100.0 nM
Cc1c(-c2ccc(C(F)(F)F)cc2)nnc(N2CCN(c3cnc(C(=O)N4CCN(S(C)(=O)=O)CC4)cn3)[C@H](C)C2)c1C CHEMBL3927593 IC50 100.0 nM
COC(=O)c1cnc(N2CCC(c3nnc(Cc4ccccc4)c(C)c3C)CC2)cn1 CHEMBL3906764 IC50 100.0 nM
Cc1c(Cc2ccccc2)nnc(C2CCN(c3ccc(C(F)(F)F)cn3)CC2)c1C CHEMBL3958040 IC50 100.0 nM
Cc1c(C(=O)c2ccccc2)nnc(N2CCN(c3cnc(C(C)(C)O)cn3)[C@H](C)C2)c1C CHEMBL3953149 IC50 100.0 nM
COC(=O)c1cnc(N2CCN(c3nnc(Cc4ccncc4)c(C)c3C)C[C@H]2C)cn1 CHEMBL3965793 IC50 100.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCC(c3nc4ncccc4[nH]3)CC2)c1C CHEMBL3958236 IC50 100.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCC(O)(c3ccc(C(C)(C)O)cn3)CC2)c1C CHEMBL3949191 IC50 100.0 nM
FC(F)(F)c1ccc(N2CCN(c3nnc(Cc4ccccc4Cl)c4c3CCC4)CC2)nc1 CHEMBL3973612 IC50 100.0 nM
Fc1cccc(Cc2nnc(N3CCN(c4ccc(C(F)(F)F)cn4)CC3)c3c2CCC3)c1 CHEMBL3965473 IC50 100.0 nM
Cc1ccccc1Cc1nnc(N2CCN(c3ccc(C(F)(F)F)cn3)CC2)c2c1CCC2 CHEMBL3955346 IC50 100.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(c3cnc(C(O)CO)cn3)[C@H](C)C2)c1C CHEMBL3971008 IC50 100.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(c3cnc(C(=O)O)cn3)[C@H](C)C2)c1C CHEMBL3897743 IC50 100.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(c3cnc(C(=O)N4C[C@@H](C)O[C@@H](C)C4)cn3)[C@H](C)C2)c1C CHEMBL3919707 IC50 100.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(c3cnc(C(=O)N4CCN(C)CC4)cn3)[C@H](C)C2)c1C CHEMBL3957247 IC50 100.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(c3cnc(C(=O)N4CCN(C(C)C)CC4)cn3)[C@H](C)C2)c1C CHEMBL3941852 IC50 100.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(c3cnc(C(=O)NCC(C)O)cn3)[C@H](C)C2)c1C CHEMBL3926840 IC50 100.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(c3cnc(C(=O)N4CCC(CCO)CC4)cn3)[C@H](C)C2)c1C CHEMBL3929514 IC50 100.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(c3cnc(C(=O)NCC(O)CO)cn3)[C@H](C)C2)c1C CHEMBL3891481 IC50 100.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(c3cnc(C(=O)NC4CC4)cn3)[C@H](C)C2)c1C CHEMBL3912445 IC50 100.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(c3cnc(C(=O)NC4CCC(O)CC4)cn3)[C@H](C)C2)c1C CHEMBL3915100 IC50 100.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(c3cnc(C(=O)N4CCNC(=O)C4)cn3)[C@H](C)C2)c1C CHEMBL3965479 IC50 100.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(c3cnc(C(=O)N(C)CCO)cn3)[C@H](C)C2)c1C CHEMBL3934557 IC50 100.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(c3cnc(C(=O)NCCCO)cn3)[C@H](C)C2)c1C CHEMBL3891390 IC50 100.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(c3cnc(C(=O)NCCN4CCOCC4)cn3)[C@H](C)C2)c1C CHEMBL3986486 IC50 100.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(c3cnc(C(=O)NCCc4ccccn4)cn3)[C@H](C)C2)c1C CHEMBL3967092 IC50 100.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(c3cnc(C(=O)NCCN4CCCC4)cn3)[C@H](C)C2)c1C CHEMBL3905798 IC50 100.0 nM
Cc1c(Cc2ccc(F)cc2)nnc(N2CCN(c3ccc(C(C)(C)C)cc3)CC2)c1C CHEMBL3948829 IC50 100.0 nM
CC(C)(C)c1ccc(N2CCN(c3nnc(Cc4ccc(F)cc4)c4c3CCCC4)CC2)cc1 CHEMBL3930632 IC50 100.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(c3ccc(C(F)(F)F)cn3)CC2)c1C CHEMBL3948598 IC50 100.0 nM
Fc1ccc(Cc2nnc(N3CCN(c4ccc(C(F)(F)F)cn4)CC3)c3c2CCCC3)cc1 CHEMBL3980924 IC50 100.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(C(=O)Oc3ccccc3)CC2)c1C CHEMBL3894764 IC50 100.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(C(=O)Nc3ccccc3)CC2)c1C CHEMBL3982279 IC50 100.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(C(=O)NCc3ccccc3)CC2)c1C CHEMBL3979837 IC50 100.0 nM
Cc1cccnc1-c1cc(N2[C@@H]3CC[C@H]2[C@@H](NS(C)(=O)=O)C3)ncc1Cl CHEMBL3696782 IC50 100.0 nM
Cc1cccnc1-c1cc(N2CCC(CNCCS(C)(=O)=O)CC2)ncc1Cl CHEMBL3696755 IC50 102.0 nM
N#Cc1ccc(N2CCN(c3nnc(Cc4ccc(F)cc4)c4ccccc34)CC2)nc1 CHEMBL496603 IC50 103.0 nM
COc1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3C)CC2)cc1 CHEMBL1209099 IC50 105.0 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)N3CCC(Nc4ccccn4)CC3)CC2)ncc1Cl CHEMBL3692761 IC50 106.0 nM
COc1cc(C(=O)NC(=O)Nc2cccc(NC(=O)c3ccccc3)c2)cc(OC)c1OC CHEMBL2031273 IC50 107.0 nM
COCCC(=O)NC1CCN(c2cc(-c3ncccc3C)c(Cl)cn2)CC1 CHEMBL3692732 IC50 107.0 nM
O=C(Nc1ccc(-c2csc(-c3ccccc3)n2)cc1)c1ccccc1Cl CHEMBL1580265 IC50 109.0 nM
CCOC(=O)N1CCN(c2cc(-c3ncccc3C)c(Cl)cn2)CC1 CHEMBL3692744 IC50 109.0 nM
C[C@H]1CN(c2nnc(-c3ccccn3)c3ccccc23)CCN1C(=O)c1ccccc1 CHEMBL1082713 IC50 110.0 nM
O=C(NCC1(N2CCC(F)CC2)CCCC1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1822449 IC50 110.0 nM
COc1ccccc1OC(=O)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1823821 IC50 110.0 nM
COc1cc(C(=O)NC(=O)Nc2cccc(NC(=O)c3cc4ccccc4[nH]3)c2)cc(OC)c1OC CHEMBL2031281 IC50 110.0 nM
COc1cc(C(=O)NC(=N)Nc2ccc(C)c(NC(=O)c3cccc(-c4ccccc4)c3)c2)cc(OC)c1OC CHEMBL2031291 IC50 110.0 nM
CS(=O)(=O)NC1CCN(c2cc(-c3ccc(C(F)(F)F)cn3)c(Cl)cn2)CC1 CHEMBL3692718 IC50 110.0 nM
Cc1cccnc1-c1cc(N2CCN(S(C)(=O)=O)CC2)ncc1Cl CHEMBL3692727 IC50 110.0 nM
O=C(CCO)NC1CCN(c2ccc(Cl)c(-c3ccccn3)n2)CC1 CHEMBL3696788 IC50 110.0 nM
CC(C)(O)CC(=O)N1CCN(c2ccc(Cl)c(-c3ccccn3)n2)CC1 CHEMBL3696749 IC50 111.0 nM
N#Cc1ccc(N2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)nc1 CHEMBL497534 IC50 112.0 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)N3CCCC(O)C3CO)CC2)ncc1Cl CHEMBL3696745 IC50 112.0 nM
CC(=O)N1CCN(c2cc(-c3ncc(C)cc3C)c(Cl)cn2)CC1 CHEMBL3696759 IC50 113.0 nM
Cc1cnc(-c2cc(N3CCC(S(C)(=O)=O)CC3)ncc2Cl)c(C)c1 CHEMBL3696792 IC50 114.0 nM
Cc1cccc(C(=O)Nc2ccc3c(c2)C[C@@H](NCc2ccccn2)C3)c1-c1ccc(C(F)(F)F)cc1 CHEMBL142972 IC50 120.0 nM
COc1ccc(CN[C@H]2Cc3ccc(NC(=O)c4cccc(C)c4-c4ccc(C(F)(F)F)cc4)cc3C2)cc1 CHEMBL471881 IC50 120.0 nM
CCCC(CCC)C(=O)NCc1ccc2c(cnn2-c2cccc(C)c2C)c1 CHEMBL551065 IC50 120.0 nM
O=C(Nc1cccnc1-c1cccc(C(F)(F)F)c1)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1807227 IC50 120.0 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)N[C@@H]3CS(=O)(=O)C[C@H]3O)CC2)ncc1Cl CHEMBL3692773 IC50 120.0 nM
CN(C(=O)c1ccc(F)cc1C(F)(F)F)C1CCN(C(=O)c2ccccc2Nc2ccnn2C)CC1 CHEMBL4644288 IC50 123.4 nM
Cc1cnc(-c2cc(N3CCN(CCS(C)(=O)=O)CC3)ncc2Cl)c(C)c1 CHEMBL3696771 IC50 124.0 nM
Cc1cccnc1-c1cc(N2CCC(OCC(=O)NC(C)(C)C)CC2)ncc1Cl CHEMBL3692747 IC50 125.0 nM
Cc1cccnc1-c1cc(N2CCN(C(=O)C(C)C)CC2)ncc1Cl CHEMBL3692749 IC50 128.0 nM
Cc1cccc(C(=O)Nc2ccc3c(c2)C[C@@H](Nc2ccccc2)C3)c1-c1ccc(C(F)(F)F)cc1 CHEMBL474302 IC50 130.0 nM
CCCC(CCC)C(=O)NCc1ccc2c(cnn2-c2ccc(F)cc2)c1 CHEMBL561069 IC50 130.0 nM
CCCC(CCC)C(=O)NCc1ccc2c(cnn2-c2ccc(OC)nc2)c1 CHEMBL550190 IC50 130.0 nM
O=C(Nc1ccccc1-c1ccccc1)N1CCN2C(=O)N([C@H]3C[C@H](c4ccccc4)C3)C(=O)C2C1 CHEMBL1808447 IC50 130.0 nM
O=C(Nc1c(Cl)cc(OC(F)(F)F)cc1Cl)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1808454 IC50 130.0 nM
COc1cc(C(=O)NC(=S)Nc2ccc(Cl)c(NC(=O)c3ccc(-c4ccccc4)cc3)c2)cc(OC)c1OC CHEMBL2031267 IC50 130.0 nM
CCN(CC)C(=O)COC1CCN(c2cc(-c3ncccc3C)c(Cl)cn2)CC1 CHEMBL3692746 IC50 131.0 nM
CS(=O)(=O)CC1CCN(c2ncc(Cl)c(-c3ccccn3)n2)CC1 CHEMBL3696751 IC50 132.0 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)NCCc3c[nH]cn3)CC2)ncc1Cl CHEMBL3696746 IC50 134.0 nM
CN1CCN(C(=O)c2cc3c(s2)CCN(c2ccc(Cl)c(-c4nc5ccccc5n4C)c2)C3)CC1 CHEMBL3819191 IC50 135.0 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)NC[C@H]3CCCO3)CC2)ncc1Cl CHEMBL3692768 IC50 137.0 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)NCC3CCCCO3)CC2)ncc1Cl CHEMBL3696742 IC50 138.0 nM
O=C(Nc1c(Cl)cccc1Cl)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1808281 IC50 140.0 nM
O=C(Nc1cccnc1-c1ccccc1Cl)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1807226 IC50 140.0 nM
O=C(Nc1c(Cl)cc(F)cc1Cl)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)[C@@H]2C1 CHEMBL1813101 IC50 140.0 nM
O=C(NCC1(NC2CCCCC2)CCCC1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1822448 IC50 140.0 nM
COc1cccc(CN(C(=O)CC(C)(C)C)[C@H]2C[C@@H](C(=O)N3CCNCC3)N(Cc3ccc4c(c3)OCO4)C2)c1 CHEMBL480889 IC50 140.0 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)N3CCc4c(c(C(C)C)nn4C)C3)CC2)ncc1Cl CHEMBL3692770 IC50 145.0 nM
CCCC(CCC)C(=O)NCc1ccc2c(cnn2-c2cccc3c2CCCC3)c1 CHEMBL557114 IC50 150.0 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)NCCc3nc4cccnc4n3C)CC2)ncc1Cl CHEMBL3692777 IC50 154.0 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)NCC3(O)CCC3)CC2)ncc1Cl CHEMBL3692769 IC50 157.0 nM
COc1cc(C(=O)NC(=N)Nc2ccc(Cl)c(C(=O)Nc3ccccc3)c2)cc(OC)c1OC CHEMBL2031295 IC50 160.0 nM
Cc1cccnc1-c1nc(N2CCC(O)CC2)ncc1Cl CHEMBL3692735 IC50 160.0 nM
COc1ccccc1CNC(=O)C1CCN(c2cc(-c3ncccc3C)c(Cl)cn2)CC1 CHEMBL3696738 IC50 161.0 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)N[C@@H]3CC[C@@H](O)C3)CC2)ncc1Cl CHEMBL3692771 IC50 162.0 nM
Cc1cccnc1-c1cc(N2CCC(OCC(C)C)CC2)ncc1Cl CHEMBL3692743 IC50 164.0 nM
O=C(NNC(=O)c1ccc([N+](=O)[O-])cc1)C(=O)c1c[nH]c2ccccc12 CHEMBL1796172 Ki 168.1 nM
Cc1cccc(C(=O)Nc2ccc3c(c2)C[C@@H](NCc2scnc2C)C3)c1-c1ccc(C(F)(F)F)cc1 CHEMBL474508 IC50 170.0 nM
O=C(Nc1ccccc1Cl)N1CCN(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1823591 IC50 170.0 nM
Cc1cccnc1-c1nc(N2CCN(S(C)(=O)=O)CC2)ncc1Cl CHEMBL3692738 IC50 172.0 nM
CC(C)c1ccccc1NC(=O)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1808459 IC50 180.0 nM
O=C(NCC1(N2CCC(F)(F)CC2)CCCC1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1822450 IC50 180.0 nM
COc1ccccc1NC(=O)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1823579 IC50 180.0 nM
COc1cc(C(=O)NC(=S)Nc2cccc(-c3cc4ccccc4[nH]3)c2)cc(OC)c1OC CHEMBL2031253 IC50 180.0 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)N[C@@H]3c4ccccc4C[C@@H]3O)CC2)ncc1Cl CHEMBL3692763 IC50 184.0 nM
N#Cc1ccc(N2CCN(c3nnc(Cc4ccc(C(F)(F)F)cc4)c4ccccc34)CC2)nc1 CHEMBL522241 IC50 185.0 nM
COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C(F)(F)F)on4)c3)c2cc1OC CHEMBL2029988 Ki 187.8 nM
Cc1cccnc1-c1cc(N2CC(C(=O)N(C)[C@@H]3CS(=O)(=O)C[C@H]3O)C2)ncc1Cl CHEMBL3639916 IC50 189.0 nM
COc1cc(C(=O)NC(=N)Nc2ccc(C)c(C(=O)Nc3ccccc3)c2)cc(OC)c1OC CHEMBL2031294 IC50 190.0 nM
COc1cc(C(=O)NC(=S)Nc2ccc(Cl)c(NC(=O)c3ccccc3)c2)cc(OC)c1OC CHEMBL2031258 IC50 190.0 nM
Cn1c(-c2cc(N3CCc4sc(C(=O)N5CCC(O)CC5)cc4C3)ccc2Cl)nc2ccccc21 CHEMBL3819380 IC50 192.0 nM
CC(=O)NCc1ccc(N2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)nc1 CHEMBL523255 IC50 196.0 nM
CC(=O)NC1CCN(c2cc(-c3ncccc3C)c(Cl)cn2)CC1 CHEMBL3692740 IC50 199.0 nM
CCCC(CCC)C(=O)NCc1ccc2c(cnn2-c2ccccc2)c1 CHEMBL564222 IC50 200.0 nM
CCCC(CCC)C(=O)NCc1ccc2c(cnn2-c2ccccc2C)c1 CHEMBL561330 IC50 200.0 nM
Cc1cnc(-c2cc(N3CCn4cc(C(=O)Nc5cccnc5)nc4C3)ncc2Cl)c(C)c1 CHEMBL3262645 IC50 200.0 nM
Cc1cccnc1-c1cc(N2CCC(COCCCO)CC2)ncc1Cl CHEMBL3692742 IC50 209.0 nM
Cc1cccc(C(=O)Nc2ccc3c(c2)C[C@@H](NCc2cnc4ccccc4c2)C3)c1-c1ccc(C(F)(F)F)cc1 CHEMBL454984 IC50 210.0 nM
O=C(Nc1ccccc1-c1ccsc1)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1807220 IC50 210.0 nM
COC1CCN(C2(CNC(=O)N3CCC(c4nc(-c5ccc6ccccc6n5)no4)CC3)CCCC2)CC1 CHEMBL1822451 IC50 210.0 nM
O=C(NCC(c1ccccc1)N1CCCCC1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1822453 IC50 210.0 nM
N#Cc1cccc(-c2nnc(N3CCN(C(=O)c4ccccc4)CC3)c3ccccc23)c1 CHEMBL1082386 IC50 212.0 nM
COCC(=O)N1CCN(c2cc(-c3ncccc3C)c(Cl)cn2)CC1 CHEMBL3692733 IC50 212.0 nM
C[C@H]1CN(c2nnc(-c3cccnc3)c3ccccc23)CCN1C(=O)c1ccccc1 CHEMBL1084241 IC50 213.0 nM
Cn1c(-c2cc(N3CCc4sc(C(=O)N5CCN(c6ccc(Cl)c(Cl)c6)CC5)cc4C3)ccc2Cl)nc2ccccc21 CHEMBL3817897 IC50 213.0 nM
C[C@@H]1CN(c2ccc(C#N)cn2)CCN1c1nnc(Cc2ccccc2)c2ccccc12 CHEMBL497639 IC50 217.0 nM
Cn1c(-c2cc(N3CCc4sc(C(=O)N5CCN(S(C)(=O)=O)CC5)cc4C3)ccc2Cl)nc2ccccc21 CHEMBL3819639 IC50 217.0 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)NCCS(C)(=O)=O)CC2)ncc1Cl CHEMBL3692772 IC50 217.0 nM
O=C(Nc1c(Cl)cc(F)cc1Cl)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1808453 IC50 220.0 nM
O=C(Nc1cccc(Cl)c1Cl)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1808279 IC50 220.0 nM
COc1cccc(NC(=O)N2CCC(c3nc(-c4ccc5ccccc5n4)no3)CC2)c1 CHEMBL1823825 IC50 220.0 nM
COc1cc(C(=O)NC(=N)Nc2cccc(NC(=O)c3ccc(N4CCOCC4)cc3)c2)cc(OC)c1OC CHEMBL2031284 IC50 220.0 nM
FC(F)(F)c1ccc(N2CCN(c3nnc(Cc4ccccc4)c4occc34)CC2)nc1 CHEMBL497412 IC50 230.0 nM
O=C(Nc1cccc(Cl)c1Cl)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)[C@@H]2C1 CHEMBL1813097 IC50 230.0 nM
O=C(NCC1(C(=O)N2CCCCC2)CCCC1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1822297 IC50 230.0 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)N3CC(S(=O)(=O)CC4CC4)C3)CC2)ncc1Cl CHEMBL3692767 IC50 234.0 nM
Cn1c(-c2cccc(N3CCc4sc(C(=O)N5CCN(c6ncccn6)CC5)cc4C3)c2)nc2ccccc21 CHEMBL3818767 IC50 237.0 nM
Cc1cccnc1-c1cc(N2CCN(C(=O)CO)CC2)ncc1Cl CHEMBL3692730 IC50 239.0 nM
Cc1cccc(C(=O)Nc2ccc3c(c2)C[C@@H](NCc2ccncc2)C3)c1-c1ccc(C(F)(F)F)cc1 CHEMBL473897 IC50 240.0 nM
O=C(NCC1(N2CCOCC2)CCCCCC1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1822303 IC50 240.0 nM
COC(=O)N1CCN(c2cc(-c3ncccc3C)c(Cl)cn2)CC1 CHEMBL3692729 IC50 243.0 nM
COC(=O)N1CCN(c2ncc(Cl)c(-c3ncccc3C)n2)CC1 CHEMBL3692741 IC50 246.0 nM
O=C(NC1CCCCC1)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1808276 IC50 250.0 nM
CCCNC(=O)COC1CCN(c2cc(-c3ncccc3C)c(Cl)cn2)CC1 CHEMBL3692745 IC50 254.0 nM
Cn1c(-c2cccc(N3CCc4sc(C(=O)Nc5cccnc5)cc4C3)c2)nc2ccccc21 CHEMBL3818148 IC50 261.0 nM
Cc1cnc(-c2cc(N3CCn4cc(C(=O)N5CCCC5)nc4C3)ncc2Cl)c(C)c1 CHEMBL3262632 IC50 270.0 nM
Cc1cnc(-c2cc(N3CCn4cc(C(=O)Nc5ccccn5)nc4C3)ncc2Cl)c(C)c1 CHEMBL3262644 IC50 270.0 nM
Cc1cnc(-c2cc(N3CCn4cc(C(=O)OCC5CC5)nc4C3)ncc2Cl)c(C)c1 CHEMBL3262647 IC50 270.0 nM
O=C(Nc1cc(Cl)cc(Cl)c1)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1808280 IC50 280.0 nM
O=C(Nc1c(Cl)cc(C(F)(F)F)cc1Cl)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1808455 IC50 280.0 nM
O=C(NC1CCCCC1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1823841 IC50 280.0 nM
O=C(OC1CCCCC1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1823842 IC50 280.0 nM
COc1cc(C(=O)NC(=S)Nc2cccc(NC(=O)c3ccccc3)c2)cc(OC)c1OC CHEMBL2031084 IC50 281.0 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)NC3CCOC4(CCN(C)CC4)C3)CC2)ncc1Cl CHEMBL3696743 IC50 283.0 nM
COc1ccccc1Nc1ccccc1C(=O)N1CCC(N(C)C(=O)c2ccc(F)cc2C(F)(F)F)CC1 CHEMBL4635021 IC50 285.25 nM
CC(C)(CNC(=O)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1)N1CCOCC1 CHEMBL1822301 IC50 290.0 nM
CCN1CCCC1CNC(=O)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1822457 IC50 290.0 nM
COc1cc(C(=O)NC(=N)Nc2cccc(NC(=O)c3ccccc3)c2)cc(OC)c1OC CHEMBL2031282 IC50 290.0 nM
Cn1c(-c2cccc(N3CCc4sc(C(=O)N5CCOCC5)cc4C3)c2)nc2ccccc21 CHEMBL3817987 IC50 294.0 nM
Cc1cccnc1-c1cc(N2CCC(C(=O)NC3CCOC3)CC2)ncc1Cl CHEMBL3696737 IC50 295.0 nM
Cc1cccnc1-c1cc(N2CCC3(CC2)CNC(=O)O3)ncc1Cl CHEMBL3692726 IC50 297.0 nM
CN(C)C1(CNC(=O)N2CCC(c3nc(-c4ccc5ccccc5n4)no3)CC2)CCCC1 CHEMBL1822444 IC50 300.0 nM
CCN1CCOCC1CNC(=O)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1822460 IC50 300.0 nM
CS(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)c(NC(=O)Nc3ccc(C(F)(F)F)cc3Cl)c2)c(Cl)c1 CHEMBL3126692 IC50 300.0 nM
Cc1cnc(-c2cc(N3CCn4cc(C(=O)Nc5ccccc5)nc4C3)ncc2Cl)c(C)c1 CHEMBL3262639 IC50 300.0 nM
NS(=O)(=O)c1ccc(N2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)nc1 CHEMBL495876 IC50 306.0 nM
CN(C(=O)c1ccc([N+](=O)[O-])cc1)C1CCN(C(=O)c2ccccc2Nc2ccnn2C)CC1 CHEMBL4639888 IC50 308.7 nM
CCCN(CCC)C(=O)NCc1ccc2c(cnn2-c2ccc(F)cc2)c1 CHEMBL560932 IC50 310.0 nM
Cn1c(-c2cc(N3CCc4sc(C(=O)N5CCCC5)cc4C3)ccc2Cl)nc2ccccc21 CHEMBL3818511 IC50 315.0 nM
O=C(Nc1ccccc1-c1ccccc1)N1CCN2C(=O)N(C3Cc4ccccc4C3)C(=O)C2C1 CHEMBL1808448 IC50 320.0 nM
CC(=O)NC1(CNC(=O)N2CCC(c3nc(-c4ccc5ccccc5n4)no3)CC2)CCCC1 CHEMBL1822298 IC50 320.0 nM
N#Cc1ccc(Cl)c(NC(=O)N2CCC(c3nc(-c4ccc5ccccc5n4)no3)CC2)c1 CHEMBL1823845 IC50 320.0 nM
CN1CCN(C(=O)c2cc3c(s2)CCN(c2cccc(-c4nc5ccccc5n4C)c2)C3)CC1 CHEMBL3817945 IC50 326.0 nM
Cc1c(CN2CCN(c3cccc(C(F)(F)F)c3)CC2)cnn1-c1ccccc1 CHEMBL1209098 IC50 328.0 nM
COCCS(=O)(=O)N1CCN(c2ccc(Cl)c(-c3ccccn3)n2)CC1 CHEMBL3696794 IC50 328.0 nM
CCCC(C)(C)C(=O)NCc1ccc2c(cnn2-c2ccc(F)cc2)c1 CHEMBL562811 IC50 330.0 nM
CC(=O)Nc1ccc(CN[C@H]2Cc3ccc(NC(=O)c4cccc(C)c4-c4ccc(C(F)(F)F)cc4)cc3C2)cc1 CHEMBL500172 IC50 340.0 nM
CCCC(CCC)C(=O)NCc1ccc2c(cnn2-c2cccnc2OC)c1 CHEMBL563112 IC50 340.0 nM
CC(C)N1CCCC1CNC(=O)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1822458 IC50 340.0 nM
O=C(Nc1ccccc1C(F)(F)F)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1823831 IC50 340.0 nM
CS(=O)(=O)NC1CCN(c2cc(-c3ccc(F)cn3)c(Cl)cn2)CC1 CHEMBL3692723 IC50 343.0 nM
CC(C)c1ccccc1NC(=O)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1823832 IC50 350.0 nM
Cn1c(-c2noc(C3CCN(C(=O)NC4CCCCC4)CC3)n2)nc2ccccc21 CHEMBL1823861 IC50 350.0 nM
Cc1cnc(-c2cc(N3CCn4cc(C(=O)Nc5ccccc5F)nc4C3)ncc2Cl)c(C)c1 CHEMBL3262640 IC50 350.0 nM
Cn1c(-c2cccc(N3CCc4sc(C(=O)N5CCCC5)cc4C3)c2)nc2ccccc21 CHEMBL3819236 IC50 352.0 nM
CC(=O)N1CCN(c2ncc(Cl)c(-c3ncccc3C)n2)CC1 CHEMBL3692731 IC50 359.0 nM
CCCC(C)C(=O)NCc1ccc2c(cnn2-c2ccc(F)cc2)c1 CHEMBL552208 IC50 360.0 nM
CN1CCc2ccccc2C1CNC(=O)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1822462 IC50 360.0 nM
Cc1c(Cl)cccc1NC(=O)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1808450 IC50 370.0 nM
COc1cc(C(=O)NC(=N)Nc2ccc(Cl)c(NC(=O)c3ccccc3)c2)cc(OC)c1OC CHEMBL2031292 IC50 370.0 nM
Cn1c(-c2cccc(N3CCc4sc(C(=O)N5CCN(S(C)(=O)=O)CC5)cc4C3)c2)nc2ccccc21 CHEMBL3818879 IC50 373.0 nM
CCCCCCNC(=O)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1808277 IC50 380.0 nM
O=C(NCC1NCCc2ccccc21)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1822461 IC50 380.0 nM
O=C(Nc1ccccc1Cl)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1823584 IC50 380.0 nM
Cc1cnc(-c2cc(N3CCn4cc(C(=O)OC(C)C)nc4C3)ncc2Cl)c(C)c1 CHEMBL3262646 IC50 380.0 nM
N#Cc1ccc(N2CCCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)nc1 CHEMBL495620 IC50 391.0 nM
CN1CCN(C2(CNC(=O)N3CCC(c4nc(-c5ccc6ccccc6n5)no4)CC3)CCCC2)CC1 CHEMBL1822452 IC50 400.0 nM
N#Cc1ccc(N2CCC(c3cn(Cc4ccccc4)c4ccccc34)CC2)nc1 CHEMBL498017 IC50 401.0 nM
Cc1cccnc1-c1cc(N2CCC3(CC2)CN(C)C(=O)O3)ncc1Cl CHEMBL3692725 IC50 407.0 nM
CC(=O)N1CCN(c2cc(-c3ncccc3C)c(Cl)cn2)CC1 CHEMBL3692728 IC50 417.0 nM
O=C(NC1CCCC1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1823840 IC50 420.0 nM
Cc1cnc(-c2cc(N3CCn4cc(C(=O)Nc5ccc(F)c(F)c5)nc4C3)ncc2Cl)c(C)c1 CHEMBL3262643 IC50 420.0 nM
O=C(Nc1cccc(Cl)c1Cl)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)[C@H]2C1 CHEMBL1813099 IC50 430.0 nM
Cn1c(-c2cccc(N3CCc4sc(C(=O)N5CCC(O)CC5)cc4C3)c2)nc2ccccc21 CHEMBL3818648 IC50 431.0 nM
Cc1cnc(-c2cc(N3CCn4cc(C(=O)Nc5ccc(F)cc5)nc4C3)ncc2Cl)c(C)c1 CHEMBL3262642 IC50 440.0 nM
C[C@@H]1CN(c2nnc(Cc3ccccc3)c3ccc(Cl)cc23)CCN1c1ccc(C#N)cn1 CHEMBL3290331 IC50 440.0 nM
Cc1ccc(NC(=O)c2cc(F)cc(N3CCCC3)c2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 CHEMBL184712 IC50 450.0 nM
Cc1ccc(NC(=O)c2cccc(N3CCOCC3)c2)cc1NC(=O)c1ccc(OCc2ccccn2)cc1 CHEMBL184721 IC50 450.0 nM
Cn1c(-c2cccc(N3CCc4sc(C(=O)N5CCN(c6ccc(Cl)c(Cl)c6)CC5)cc4C3)c2)nc2ccccc21 CHEMBL3818296 IC50 456.0 nM
O=C(Nc1ccc(Cl)cc1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1823830 IC50 470.0 nM
O=C(Nc1ccc(F)c(Cl)c1Cl)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1808452 IC50 480.0 nM
O=C(Nc1ccccc1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1823824 IC50 480.0 nM
O=C(NC1CCC(F)(F)CC1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1823860 IC50 480.0 nM
OCc1ccc(N2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)nc1 CHEMBL498457 IC50 484.0 nM
N#Cc1ccccc1NC(=O)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1823833 IC50 490.0 nM
Cc1ccccc1NC(=O)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1823828 IC50 510.0 nM
CS(=O)(=O)NC1CCN(c2cc(-c3ncc(Cl)cc3F)c(Cl)cn2)CC1 CHEMBL3692722 IC50 511.0 nM
COc1cc(C(=O)NC(=S)Nc2ccc(Cl)c(C(=O)Nc3ccccc3)c2)cc(OC)c1OC CHEMBL2031080 IC50 520.0 nM
Cc1cnc(-c2cc(N3CCn4cc(C(=O)NCC5CC5)nc4C3)ncc2Cl)c(C)c1 CHEMBL3262630 IC50 520.0 nM
Cc1cccc(Cl)c1NC(=O)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1808451 IC50 530.0 nM
COC[C@H]1CCCN1C(=O)c1cn2c(n1)CN(c1cc(-c3ncc(C)cc3C)c(Cl)cn1)CC2 CHEMBL3262636 IC50 550.0 nM
COc1ccc(C(=O)N(C)C2CCN(C(=O)c3ccccc3Nc3ccnn3C)CC2)cc1 CHEMBL4632537 IC50 561.9 nM
Cn1cc(-c2ncccc2NC(=O)N2CCN3C(=O)N([C@H]4C[C@@H]4c4ccccc4)C(=O)C3C2)cn1 CHEMBL1807230 IC50 620.0 nM
C[C@@H]1C[C@H](c2nc(-c3ccc4ccccc4n3)no2)CCN1C(=O)Nc1ccccc1Cl CHEMBL1823587 IC50 620.0 nM
NC1(CNC(=O)N2CCC(c3nc(-c4ccc5ccccc5n4)no3)CC2)CCCC1 CHEMBL1822445 IC50 630.0 nM
C[C@H]1C[C@H](c2nc(-c3ccc4ccccc4n3)no2)CCN1C(=O)Nc1ccccc1Cl CHEMBL1823586 IC50 640.0 nM
COc1cc(C(=O)NC(=N)Nc2cccc(NC(=O)c3cn4ccsc4n3)c2)cc(OC)c1OC CHEMBL2031285 IC50 640.0 nM
COCC(=O)Nc1cn2c(n1)CN(c1cc(-c3ncc(C)cc3C)c(Cl)cn1)CC2 CHEMBL3262654 IC50 650.0 nM
CN(C)Cc1ccc(N2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)nc1 CHEMBL495877 IC50 654.0 nM
O=C(Nc1cccc(Cl)c1Cl)N1CCN2C(=O)N([C@@H]3C[C@H]3c3ccccc3)C(=O)[C@@H]2C1 CHEMBL1813098 IC50 670.0 nM
O=C(N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1)N1CCCc2ccccc21 CHEMBL1823829 IC50 670.0 nM
CCCC(CCC)C(=O)NCc1ccc2c(cnn2-c2cccc(F)c2)c1 CHEMBL556427 IC50 680.0 nM
O=C(Nc1cccnc1-c1ccc(Cl)cc1)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1807224 IC50 680.0 nM
Cn1c(-c2noc(C3CCN(C(=O)NC4CCS(=O)(=O)CC4)CC3)n2)nc2ccccc21 CHEMBL1823862 IC50 690.0 nM
CCOC(=O)c1cn2c(n1)CN(c1cc(-c3ncc(C)cc3C)c(Cl)cn1)CC2 CHEMBL3262627 IC50 690.0 nM
O=C(Nc1ccc2c(c1)OCO2)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1808283 IC50 700.0 nM
CCC(CC)C(=O)NCc1ccc2c(cnn2-c2ccc(F)cc2)c1 CHEMBL550254 IC50 720.0 nM
NC(=O)c1ccc(N2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)nc1 CHEMBL495875 IC50 724.0 nM
Cc1cnc(-c2cc(N3CCn4cc(C(=O)OC5CCCC5)nc4C3)ncc2Cl)c(C)c1 CHEMBL3262648 IC50 740.0 nM
COc1ccccc1NC(=O)N1CCC(c2nc(-c3cc4ccccc4cn3)no2)CC1 CHEMBL1823602 IC50 750.0 nM
O=C(NCC1CCC1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1823839 IC50 750.0 nM
COc1ccc(Nc2ccccc2C(=O)N2CCC(N(C)C(=O)c3ccc(F)cc3C(F)(F)F)CC2)cc1 CHEMBL4645447 IC50 754.05 nM
Cc1cccc(C(=O)Nc2ccc3c(c2)C[C@H](NCc2nccs2)C3)c1-c1ccc(C(F)(F)F)cc1 CHEMBL474892 IC50 770.0 nM
O=C(Nc1ccc2c(c1)CC(NCc1ccccn1)C2)c1ccccc1-c1ccc(C(F)(F)F)cc1 CHEMBL473892 IC50 790.0 nM
CC1CN(C(=O)Nc2ccccc2Cl)CCC1c1nc(-c2ccc3ccccc3n2)no1 CHEMBL1823585 IC50 790.0 nM
Cc1cnc(-c2cc(N3CCn4cc(C(=O)N5CCOCC5)nc4C3)ncc2Cl)c(C)c1 CHEMBL3262633 IC50 790.0 nM
O=C(NCC1(c2ccccc2)CCCC1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1822295 IC50 810.0 nM
COc1cc(C(=O)NC(=S)Nc2cccc(-c3cn4ccccc4n3)c2)cc(OC)c1OC CHEMBL2031254 IC50 820.0 nM
O=C(NC1CCS(=O)(=O)CC1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1823859 IC50 860.0 nM
O=C(Nc1ccc(-c2ccccc2)cc1)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1808286 IC50 890.0 nM
O=C(Nc1ccccc1C(F)(F)F)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1808460 IC50 890.0 nM
CCC(=O)Nc1cn2c(n1)CN(c1cc(-c3ncc(C)cc3C)c(Cl)cn1)CC2 CHEMBL3262653 IC50 890.0 nM
CCCC(CCC)C(=O)NCc1ccc2c(cnn2-c2ccccc2F)c1 CHEMBL550661 IC50 900.0 nM
CCCC(CCC)C(=O)NCc1ccc2c(cnn2-c2ccc(C)cc2)c1 CHEMBL563992 IC50 900.0 nM
COc1cc(C(=O)NC(=N)Nc2cccc(-n3ccc4ccccc43)c2)cc(OC)c1OC CHEMBL2031286 IC50 900.0 nM
O=C(NCC1(CO)CCCC1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1822296 IC50 910.0 nM
Cc1cnc(-c2cc(N3CCn4cc(CN5CCOCC5)nc4C3)ncc2Cl)c(C)c1 CHEMBL3262651 IC50 910.0 nM
CCCCN(CCCC)C(=O)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1 CHEMBL1808278 IC50 920.0 nM
CCCC(CCC)C(=O)NCc1ccc2c(cnn2-c2c(C)cccc2C)c1 CHEMBL561995 IC50 950.0 nM
Cc1cnc(-c2cc(N3CCn4cc(C(=O)Oc5ccccc5)nc4C3)ncc2Cl)c(C)c1 CHEMBL3262649 IC50 960.0 nM
CN(C(=O)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1)c1ccccc1-c1ccccc1 CHEMBL1808285 IC50 1000.0 nM
O=C(Nc1ccccc1Cl)N1CCC(F)(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1823590 IC50 1000.0 nM
Cn1c(-c2noc(C3CCN(C(=O)Nc4ccccc4Cl)CC3)n2)nc2ccccc21 CHEMBL1823616 IC50 1000.0 nM
O=C(CC1CCCCCC1)N1CCC(c2nc(-c3ccc4ccccc4n3)no2)CC1 CHEMBL1823617 IC50 1000.0 nM
Cc1c(-c2ccc(F)cc2)nnc(N2CCN(c3cnc(C(=O)O)cn3)[C@H](C)C2)c1C CHEMBL3960935 IC50 1000.0 nM
Cc1c(-c2ccc(C(C)C)cc2)nnc(N2CCN(c3ccc(C(F)(F)F)cn3)CC2)c1C CHEMBL3969729 IC50 1000.0 nM
COC(=O)c1cnc(N2CCN(c3nnc(-c4ccccc4-c4ccccc4)c(C)c3C)C[C@H]2C)cn1 CHEMBL3919359 IC50 1000.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCC(N3Cc4ccccc4C3)CC2)c1C CHEMBL3906243 IC50 1000.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCC(c3ncc(Cl)[nH]3)CC2)c1C CHEMBL3896503 IC50 1000.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCC(C)(c3nc4ncccc4[nH]3)CC2)c1C CHEMBL3955601 IC50 1000.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCC(C#N)(c3ccc(C(C)(C)O)cn3)CC2)c1C CHEMBL3892588 IC50 1000.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCC(c3nc(C(F)(F)F)c[nH]3)CC2)c1C CHEMBL3889851 IC50 1000.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCC(N3CCc4ccccc4C3)CC2)c1C CHEMBL3951798 IC50 1000.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(c3cncc(C(N)=O)n3)[C@H](C)C2)c1C CHEMBL3938550 IC50 1000.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(c3ncc(C(=O)O)c(C(F)(F)F)n3)[C@H](C)C2)c1C CHEMBL3910002 IC50 1000.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(c3cnc(C(=O)NCCN4CCN(C)CC4)cn3)[C@H](C)C2)c1C CHEMBL3938334 IC50 1000.0 nM
Cc1c(Cc2ccccc2)nnc(N2CCN(Cc3ccccc3)CC2)c1C CHEMBL3915704 IC50 1000.0 nM
Cc1nc(Cc2nnc(N3CCN(c4ccc(C(F)(F)F)cn4)CC3)c(C)c2C)no1 CHEMBL3934007 IC50 1000.0 nM
Cc1nnc(Cc2nnc(N3CCN(c4ccc(C(F)(F)F)cn4)CC3)c(C)c2C)o1 CHEMBL3967151 IC50 1000.0 nM
c1ccc2c(Oc3nc(Nc4ccc(N5CCOCC5)cc4)c4ncn(C5CCCCC5)c4n3)cccc2c1 CHEMBL1221984 EC50 1000.0 nM